Hub : Genes

PKDCC

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.189	0.0490	9.3e-08	0.020	0.056	0.039	0.054	0.051	1.6e-03	2.1e-07	1.6e-05	3.2e-07	6.7e-07
2	GTEx	Adipose Subcutaneous	0.110	0.0490	9.9e-03	-0.002	NA	0.028	NA	0.009	4.6e-01	NA	2.2e-03	NA	5.5e-02
3	GTEx	Esophagus Gastroesophageal Junction	0.572	0.1230	4.4e-04	0.006	NA	0.010	NA	0.003	1.9e-01	NA	1.4e-01	NA	2.5e-01
4	GTEx	Heart Left Ventricle	0.276	0.0841	9.6e-04	0.081	NA	0.111	NA	0.138	4.3e-05	NA	1.7e-06	NA	8.7e-08
5	ROSMAP	Brain Pre-frontal Cortex	0.249	0.0543	1.3e-07	0.060	0.049	0.061	0.056	0.034	3.7e-08	5.8e-07	2.9e-08	8.5e-08	3.1e-05
6	TCGA	Colon Adenocarcinoma	0.052	0.0320	8.0e-03	0.009	0.039	0.005	NA	0.015	9.3e-02	2.6e-03	1.6e-01	NA	4.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.6	0.9	2.8	-0.5	1.1	0.2	-1.7	0.3	1.0
Bipolar Disorder or Schizophrenia	0.3	0.7	1.1	-0.9	0.7	0.6	-1.0	0.9	0.9
Depressed Affect (Nagel 2018)	0.4	0.8	3.5	-0.6	-1.9	-0.3	-0.5	0.5	-0.4
Depression (Nagel 2018)	0.6	0.9	3.4	0.2	-1.2	0.6	-1.9	-0.6	-0.3
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.1	-0.2	-0.5	0.3	-1.1	0.0	-0.2
Neuroticism (Nagel 2018)	0.4	0.8	2.3	-1.5	-1.4	-0.4	0.1	-0.2	-0.8
Schizophrenia (2018)	0.1	0.3	0.7	-0.7	0.0	0.7	0.0	0.8	0.4
Schizophrenia vs Biploar Disorder	0.8	1.1	5.9	-0.4	-2.4	0.5	-0.4	-0.5	0.1
Worry (Nagel 2018)	0.2	0.5	1.3	-0.9	0.1	-0.6	1.2	-0.1	-0.4
Alzheimer’s Disease (in mother)	0.2	0.3	1.1	-0.3	1.0	-0.0	0.1	0.1	-0.6
Alzheimer’s Disease (in father)	1.1	1.2	3.0	-0.5	1.5	0.8	1.7	-0.9	-0.2
Alzheimer’s Disease (including proxy)	1.1	1.7	4.9	-0.3	2.2	0.9	1.9	-0.3	-0.7
Crohns Disease (2017)	0.0	0.1	0.5	0.2	0.0	-0.7	-0.1	0.3	-0.1
Irritable Bowel Disease (IBD)	0.3	0.6	2.2	-0.0	0.1	0.2	-1.0	-0.5	-1.5
Ulcerative Colitis (UC)	0.7	1.2	3.8	-0.0	-0.4	1.1	-1.4	-0.5	-1.9
Major Depression (MDD)	0.2	0.3	1.2	0.1	-0.3	0.6	-0.2	-1.1	0.1
Reaction Time	0.2	0.5	1.1	-0.2	-0.4	-0.7	0.9	-0.5	-1.0
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.3	-0.1	-1.5	1.1	-1.2	1.2	-0.1
Breast Cancer	1.1	2.6	6.3	-1.7	1.9	-0.9	2.5	-0.6	1.4
Ovarian Cancer	1.8	2.3	7.7	2.8	-0.5	-1.4	-1.3	0.0	1.5
Prostate Cancer	1.2	1.6	8.1	0.9	0.4	0.8	-0.1	2.8	0.1
Age at First Birth	0.4	0.6	2.1	1.0	-1.4	-0.0	-0.4	0.3	0.6
Bipolar Disorder (2011)	0.8	0.8	2.4	0.5	0.7	-0.5	-1.6	1.1	-0.4
Body Mass Index (BMI) (2010)	0.3	0.5	1.5	-0.5	0.2	-0.7	-1.2	0.5	0.4
Coronary Artery Disease (CAD)	0.3	0.3	0.6	0.0	0.8	0.0	0.5	0.8	-0.7
Crohns Disease (2012)	0.1	0.2	0.7	-0.4	0.5	-0.8	-0.1	-0.5	-0.0
Mean Putamen Volume	0.6	0.6	2.4	0.7	-0.5	-0.6	0.5	0.3	1.6
Fasting Glucose	0.8	1.0	3.0	0.6	-0.5	0.3	-1.5	1.7	0.3
HbA1C	1.1	1.2	2.6	1.6	-0.1	1.1	-0.9	0.4	-1.6
HDL Cholesterol	0.4	0.6	1.9	0.2	0.3	0.5	-1.2	1.4	0.2
LDL Cholesterol	0.1	0.2	0.4	0.6	-0.1	0.2	-0.2	0.7	-0.5
Lupus	0.1	0.2	0.4	0.1	0.6	0.5	-0.6	0.3	-0.5
Neuroticism (2016)	0.5	0.7	3.2	0.2	-1.8	-0.2	-1.0	-0.3	-0.3
Primary Biliary Cirrhosis	1.0	1.5	3.2	-0.3	-0.1	-1.8	1.6	-1.7	0.4
Rheumatoid Arthritis	0.6	0.8	2.6	0.5	-1.6	-0.8	0.8	0.2	-0.7
Schizophrenia (2014)	0.3	0.8	1.9	0.4	-0.1	1.1	-0.6	1.4	1.0
Triglycerides	0.7	1.1	2.1	1.4	0.0	-1.3	1.5	-1.0	-0.4
Type 2 Diabetes (T2D) (2012)	1.1	1.3	6.2	-0.1	2.5	1.1	0.5	0.4	0.1
Ulcerative Colitis	0.8	1.1	3.7	-0.4	-1.1	0.9	-0.6	-0.5	-1.9
Blood Eosinophil Count	0.2	1.2	2.7	1.4	1.2	-1.6	0.5	-0.1	0.9
Blood Platelet Count	0.5	5.6	15.3	-1.5	-0.8	3.5	-1.8	-0.3	-3.9
Blood Red Count	0.5	5.1	13.2	1.4	0.9	-1.5	3.1	-1.6	3.6
Blood White Count	0.4	2.8	7.5	-1.3	-0.7	2.7	-1.9	-0.6	-1.8
Heel T-Score	13.1	104.1	237.2	15.4	-4.6	-9.0	-7.4	4.8	14.4
BMI	0.8	4.4	13.8	-1.0	0.2	-3.7	1.8	-2.9	0.2
Height	0.5	8.7	25.7	2.3	-1.8	-3.9	-5.1	1.5	0.9
Waist Hip Ratio (WHR)	1.1	4.9	9.5	-2.2	-2.0	2.8	-1.9	-0.1	-3.1
Systolic Blood Pressure	0.3	1.4	4.0	0.2	0.0	2.0	1.8	1.1	0.1
Smoking Status	0.7	1.8	4.0	-0.4	1.2	1.4	-2.0	-0.4	-1.7
Allergy or Eczema	0.2	0.5	1.5	0.5	0.5	0.3	-0.9	1.2	-0.6
Cardiovascular Disease	0.7	2.3	4.2	-1.8	-0.8	1.5	-1.2	-1.5	-2.0
Hypothyroidism (self reported)	0.6	1.4	4.4	0.1	0.0	0.1	-2.0	-0.3	-2.1
Respiratory disease	0.3	0.6	1.6	0.2	-0.2	-0.4	0.5	-1.2	-1.3
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.1	-0.5	1.1	-0.3	-0.2	1.0	0.2
Lung FEV1/FVC ratio	0.9	4.6	12.5	2.5	-2.4	-0.3	-1.7	3.5	0.2
Lung FVC	1.9	9.4	27.2	2.0	2.0	-2.9	3.3	1.3	5.2
Neuroticism	0.6	1.4	4.1	-1.4	-2.0	-0.4	-0.4	0.7	-1.3
Chronotype (morning person)	0.8	1.9	10.4	0.2	0.6	-0.2	3.2	0.4	-0.4
Hair Pigment	1.9	54.2	228.0	-2.4	7.9	-1.4	15.1	-4.3	2.8
Tanning	0.1	0.8	1.5	1.2	0.2	-0.5	-1.1	-0.8	1.2
Hand grip strength (left)	3.3	8.8	23.1	3.8	1.0	-3.2	1.7	1.1	4.8
Number of treatments/medications taken	0.6	1.1	2.9	-1.5	0.0	-0.1	-1.7	-1.0	-0.8
Average weekly spirits intake	1.7	2.1	5.5	2.3	-0.1	1.0	0.3	2.3	-0.6
Sensitivity / hurt feelings	1.0	1.7	3.5	-1.6	-1.1	0.6	-0.2	1.9	-1.7
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.7	0.3	-1.0	0.8	-0.8	1.3	0.4
Hearing difficulty/problems: Yes	0.2	0.4	0.9	0.4	0.9	-0.8	0.2	-0.7	-0.0
Relative age of first facial hair	0.7	1.3	5.3	-2.3	-0.1	0.1	-0.7	-1.2	0.9
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.6	-0.0	0.7	-0.3	0.2	0.8	-0.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.4	-0.1	0.9	1.2	-0.1	-0.7	-0.5
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	0.2	0.5	0.6	0.1	-0.7	-0.8
Systolic blood pressure, automated reading	0.5	1.6	5.1	-0.1	0.1	1.3	2.2	0.9	-1.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	3.5	0.2	0.7	-0.7	-0.4	-1.9	0.8
Angina	1.0	1.3	4.7	1.4	0.2	-2.2	-0.2	-0.1	0.9
Medication for hormone replacement therapy	0.7	0.8	2.4	0.6	1.1	-0.6	-0.1	-0.7	1.6
Vitamin and mineral supplements	0.2	0.3	0.8	-0.9	-0.3	0.3	-0.4	-0.8	-0.2
Supplements: Zinc	1.1	1.2	2.7	1.1	1.0	-1.1	-0.5	0.9	1.6
Medication: Co-codamol	1.4	1.6	4.1	-0.2	-1.7	0.8	-1.2	0.8	-2.0
Medication: Metformin	0.5	0.7	1.3	-1.0	1.2	-0.7	-0.0	-0.1	-1.1
Diabetes (father)	1.1	1.3	2.4	-1.5	-0.4	-1.0	1.2	-1.6	0.8
Diabetes (mother)	2.2	2.8	9.1	1.0	2.3	-0.5	3.0	1.2	-0.3
Severe depression (siblings)	0.3	0.3	0.8	-0.4	-0.3	-0.3	-0.9	0.7	-0.6
Pack years adult smoking proportion	1.3	1.9	4.7	-2.2	0.5	0.6	-0.1	-1.3	-2.1
Impedance of leg (right)	0.3	1.7	7.3	-0.5	-1.0	2.7	-0.7	-0.2	-1.0
Leg fat-free mass (left)	0.5	2.6	13.5	0.6	-0.6	-3.7	-0.0	0.0	1.3
Trunk fat percentage	0.8	3.1	8.5	-1.6	-0.6	-2.3	1.4	-2.9	-0.5
Hand grip strength (right)	2.5	6.8	18.2	3.8	-0.5	-2.6	0.8	0.8	4.3
Townsend deprivation index at recruitment	0.7	0.9	2.5	1.3	1.6	-1.1	0.0	-0.2	0.7
Current tobacco smoking	1.1	1.8	7.2	-0.6	2.7	0.8	0.2	-1.4	-0.8
Average weekly fortified wine intake	0.6	0.7	1.7	-0.7	0.5	0.6	-0.1	1.1	-1.3
Maternal smoking around birth	1.1	1.6	2.9	1.1	-0.9	-1.7	1.3	0.8	1.5
Fed-up feelings	0.4	0.7	1.5	-0.9	-1.2	-0.2	0.4	0.8	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	0.6	-0.6	0.0	-0.8	0.1	0.4
Relative age voice broke	0.5	0.7	3.3	-0.6	0.6	0.1	0.5	-1.8	0.4
Taking other prescription medications	1.1	1.7	4.1	-2.0	1.0	0.1	-0.9	-0.8	-1.8
Age when periods started (menarche)	0.1	0.2	0.4	-0.3	0.4	-0.6	0.6	0.3	0.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.0	0.9	0.4	0.8	-0.8	-0.6	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	5.3	12.1	32.3	5.7	-1.6	-3.3	-2.1	-0.7	4.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.6	-0.0	-0.6	1.3	-0.5	0.3	0.1
Qualifications: CSEs or equivalent	0.6	0.8	2.0	0.3	-0.7	0.7	1.1	0.7	1.4
Serious illness, injury or assault to yourself	0.9	1.1	2.6	-1.6	-0.7	0.7	-1.5	0.5	-0.7
High blood pressure	0.5	1.4	2.7	-1.6	-0.5	1.6	0.2	-0.5	-1.6
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.1	-0.0	0.0	1.5	-1.0	1.3	-0.3
Multivitamins +/- minerals	0.7	0.9	1.5	1.2	1.2	-1.1	0.5	0.4	0.9
Stomach or abdominal pain in last month	1.1	1.3	2.0	-1.2	-1.4	1.4	-0.7	1.2	-0.7
Supplements: Glucosamine	0.7	1.0	2.9	1.3	-0.1	1.7	-0.1	0.7	-0.9
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	4.2	0.2	0.4	0.1	0.1	1.2	2.1
Medication: Atenolol	2.5	3.1	7.9	0.9	0.9	-1.6	2.8	-0.8	2.4
Medication: Levothyroxine sodium	0.5	0.8	2.4	0.0	0.8	-0.2	-1.0	-0.7	-1.6
Sitting height	1.0	6.9	22.3	3.5	-0.3	-2.5	0.0	0.3	4.7
Chronic bronchitis/emphysema (father)	0.8	0.9	4.0	-0.3	-0.2	0.4	-0.1	-1.1	-2.0
High blood pressure (mother)	0.8	1.1	3.3	1.0	0.4	-1.1	0.9	-0.1	1.8
Body mass index (BMI)	0.5	2.3	8.9	-0.3	0.3	-3.0	1.4	-1.5	0.8
Impedance of leg (left)	0.3	1.5	7.3	-0.4	-0.9	2.7	-0.6	0.4	-0.7
Leg predicted mass (left)	0.5	2.6	13.5	0.6	-0.5	-3.7	0.1	0.0	1.3
Trunk fat mass	0.7	2.9	9.7	-0.9	-0.5	-3.1	1.0	-2.4	0.1
Waist circumference	0.4	1.3	4.7	-1.1	-0.7	-2.2	-0.0	-1.1	-0.3
Number of incorrect matches in round	0.3	0.5	2.0	-0.1	0.1	0.1	1.4	-0.1	-1.1
Past tobacco smoking	0.4	0.8	2.1	-0.1	-0.7	-0.4	1.4	-0.4	1.4
Alcohol usually taken with meals	0.8	1.3	4.9	-0.6	0.7	-0.7	2.2	1.1	-0.0
Nervous feelings	0.4	0.7	2.3	-1.5	-0.7	0.1	0.9	0.6	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.6	-0.8	-1.6	0.7	-0.8	1.1	-0.3
Hearing difficulty/problems with background noise	0.2	0.4	0.9	-0.6	0.7	-0.1	0.7	-0.3	-1.0
Hair/balding pattern: Pattern 2	2.9	3.7	8.2	2.1	-2.9	1.7	-0.2	2.0	-1.6
Had menopause	1.6	2.0	9.5	-0.7	0.8	0.6	0.4	-1.0	-3.1
Had other major operations	0.3	0.4	1.4	0.2	0.3	1.2	0.4	-0.3	-0.7
Forced vital capacity (FVC)	1.7	6.7	23.7	1.8	-1.1	-2.3	0.4	2.5	4.9
Heel bone mineral density (BMD) T-score, automated (right)	7.6	17.4	48.7	7.0	-2.1	-3.8	-1.9	-0.4	5.8
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.4	-1.6	-0.4	1.2	-0.9	0.7	-0.1
Qualifications: None of the above	0.1	0.1	0.4	-0.7	0.0	-0.3	0.4	0.0	-0.1
Financial difficulties in last 2 years	0.9	1.2	2.9	-1.0	-0.7	1.7	-1.2	1.1	-0.4
Mouth/teeth dental problems	0.8	1.2	3.7	-0.6	-1.9	-1.1	-1.1	0.6	0.5
Heart attack	0.6	0.8	3.2	-0.3	-0.3	-1.8	0.5	-0.4	0.9
Allergy	0.2	0.5	0.8	0.6	0.1	-0.9	0.8	-0.7	0.8
Pain all over the body in last month	0.8	0.8	2.6	1.6	0.6	-0.3	-1.3	0.0	0.5
Diabetes (self-reported)	0.3	0.5	1.4	0.0	1.2	-0.9	-0.7	-0.4	-0.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.1	-1.1	-0.4	-0.4	-0.2	-0.1	-0.9
Medication: Ramipril	0.5	0.6	1.7	-0.4	-0.8	0.5	-1.3	-0.5	-0.7
Medication: Simvastatin	0.9	1.3	4.2	-0.4	1.3	-2.1	0.5	-1.0	0.6
Fluid intelligence score	0.2	0.5	1.1	-0.1	-1.1	1.0	-0.6	0.5	-0.5
Illnesses of siblings	0.7	0.9	1.8	1.2	-1.4	-0.7	-0.7	0.1	1.1
Neuroticism score	0.8	1.7	5.1	-1.8	-2.2	-0.5	-0.6	1.0	-0.2
Weight	0.6	3.0	14.6	0.3	-0.5	-3.8	0.2	-1.0	1.3
Impedance of arm (right)	0.6	2.9	5.8	-2.4	-0.9	2.1	-0.6	-1.4	-2.0
Arm fat percentage (right)	0.7	2.7	6.6	-1.6	0.0	-2.3	1.4	-2.6	-0.1
Trunk fat-free mass	0.9	4.9	12.5	1.8	-0.6	-3.5	-1.6	1.8	2.8
Hip circumference	0.7	3.0	12.8	0.3	0.2	-3.6	1.3	-0.8	1.6
Time employed in main current job	1.0	1.2	4.6	1.2	0.9	2.1	0.1	0.3	-0.1
Alcohol intake versus 10 years previously	2.6	3.9	7.3	0.7	1.9	-2.7	1.4	-2.1	2.4
Father’s age at death	0.9	1.2	5.9	-0.7	0.3	0.6	2.4	-0.7	-0.0
Worrier / anxious feelings	0.3	0.6	2.3	-1.5	-0.4	0.3	-0.2	-0.5	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	4.9	-1.4	-2.0	0.7	-2.2	0.3	-0.2
Falls in the last year	0.4	0.6	1.1	-0.8	-0.8	0.2	-0.9	-0.5	-1.1
Hair/balding pattern: Pattern 3	0.3	0.4	0.9	0.4	-0.3	0.8	-0.9	-0.8	-0.3
Number of live births	0.4	0.5	1.8	-0.3	0.1	1.3	-0.2	-0.0	-1.1
Forced expiratory volume in 1-second (FEV1)	2.4	8.1	21.7	2.1	-2.1	-2.1	0.3	3.7	4.7
Pulse rate	0.1	0.2	0.3	-0.4	-0.6	0.5	-0.3	-0.5	-0.2
Happiness	0.9	1.1	3.3	-0.6	-0.8	0.2	1.8	1.2	0.9
Noisy workplace	1.2	1.5	6.0	2.5	0.6	-0.5	0.7	0.8	1.0
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.5	-1.6	0.7	0.1	-0.7	-1.3	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	4.0	-1.0	-0.5	-0.6	-2.0	-0.8	0.4
Mouth/teeth dental problems: Dentures	0.3	0.5	1.7	1.3	0.2	0.7	-0.3	-0.8	-0.3
Asthma	0.5	1.1	5.6	0.3	-0.3	0.3	-0.0	-0.8	-2.4
Medication: Ibuprofen (e.g. Nurofen)	2.7	3.5	12.7	2.1	-1.0	-0.3	-0.2	3.6	1.6
Medication: Cholesterol lowering	1.7	2.7	9.7	-1.3	1.3	-3.1	-0.2	-1.6	0.7
Depression (self-reported)	1.3	1.6	4.4	0.5	-1.8	0.5	-2.1	1.0	-0.6
Medication: Lansoprazole	0.2	0.3	0.6	0.4	-0.7	0.3	0.0	0.5	0.7
Prospective memory result	0.7	0.8	1.6	1.1	-0.4	-0.6	0.3	1.3	1.2
Lung cancer (father)	0.3	0.3	1.1	-0.2	-0.6	1.1	0.3	0.4	-0.5
Illnesses of mother	1.7	2.1	3.4	-1.0	-1.8	1.2	-1.4	1.7	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.5	8.1	25.4	2.5	-1.7	-2.4	0.7	2.8	5.0
Pulse wave Arterial Stiffness index	2.0	2.3	7.1	-0.3	-2.7	0.4	-1.2	1.7	-1.5
Impedance of arm (left)	0.8	3.8	6.4	-2.5	-1.6	2.4	0.2	-1.6	-2.2
Arm fat mass (right)	0.5	2.2	8.6	-0.7	-0.0	-2.9	1.0	-1.6	0.5
Trunk predicted mass	0.9	4.9	12.1	1.9	-0.6	-3.5	-1.6	1.8	2.8
Standing height	0.3	3.2	5.6	1.5	-1.8	-2.4	-2.3	1.1	1.3
Length of working week for main job	0.5	0.6	1.3	-0.8	-0.0	0.8	0.8	0.6	-1.2
Exposure to tobacco smoke at home	0.2	0.3	1.2	-0.5	0.4	0.2	-1.1	-0.1	-0.0
Breastfed as a baby	0.3	0.3	1.2	-0.1	0.5	0.4	-0.5	0.3	-1.1
Tense / ‘highly strung’	0.7	1.1	3.6	-0.2	-1.9	0.0	0.6	1.7	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.6	0.1	-0.1	0.3	-0.5	-0.4	-1.3
Hair/balding pattern: Pattern 4	0.5	1.2	4.6	1.1	2.2	-0.2	0.9	0.3	0.7
Birth weight of first child	0.5	1.0	1.7	-0.8	1.2	-0.7	-1.3	-1.3	0.3
Peak expiratory flow (PEF)	2.8	6.4	12.9	3.2	-2.9	-1.0	-0.3	3.6	2.4
Pulse wave reflection index	0.4	0.5	1.6	-0.3	-0.4	0.0	1.3	1.0	-0.6
Ever highly irritable/argumentative for 2 days	2.1	2.6	6.2	1.5	-2.5	1.3	0.3	1.9	1.2
Loud music exposure frequency	0.5	0.6	2.2	-0.2	1.5	1.0	-0.4	-0.1	0.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	5.3	-0.9	2.3	-0.5	0.5	-0.0	1.0
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	4.3	-1.1	0.0	2.1	0.2	1.5	-1.5
Blood clot in the leg (DVT)	0.4	0.5	1.4	-1.2	0.5	-1.0	0.2	-0.3	0.4
Medication: Paracetamol	0.9	1.4	3.4	0.3	-0.2	0.5	-1.5	1.6	1.8
Headache pain in last month	0.5	0.8	2.4	-0.7	-0.1	1.2	-1.6	0.8	0.1
Medication for cholesterol, blood pressure or diabetes	1.4	2.2	5.4	1.8	-1.0	2.3	-0.4	1.9	-0.0
Glaucoma (self-reported)	1.1	1.3	2.8	0.5	-1.0	0.6	-1.0	1.7	-1.4
Gout (self-reported)	0.3	0.4	0.9	-0.7	-0.3	-0.9	0.3	-0.7	-0.1
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.0	0.7	1.1	-0.0	-1.3	-0.4	-1.4
Medication: Amlodipine	0.7	0.9	2.3	-0.1	-1.0	1.3	1.5	-0.3	-0.6
Medication: Ventolin 100micrograms inhaler	1.9	2.4	7.5	-1.9	0.2	2.7	0.3	0.2	-1.8
Birth weight	0.6	1.2	3.0	-1.7	1.1	0.3	-1.2	-0.9	-0.8
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.4	1.2	-0.5	-0.1	0.2	0.7	-0.2
High blood pressure (siblings)	0.7	1.1	4.0	-2.0	1.1	-0.2	-0.0	-0.3	-1.0
Forced vital capacity (FVC), Best measure	2.0	7.3	26.9	2.2	-0.9	-2.4	1.3	1.9	5.2
Body fat percentage	0.8	3.2	8.9	-1.4	-0.2	-2.4	1.7	-3.0	-0.3
Leg fat percentage (right)	0.7	2.5	8.0	-0.6	0.3	-2.1	1.4	-2.8	-0.4
Arm fat-free mass (right)	0.8	3.9	12.7	1.7	-0.5	-3.6	-0.4	1.1	2.5
Exposure to tobacco smoke outside home	0.3	0.4	1.2	-0.9	-0.3	-0.3	0.3	-1.1	-0.6
Comparative body size at age 10	1.0	2.7	11.2	0.3	0.6	-1.6	1.1	-3.3	0.7
Number of full brothers	0.1	0.1	0.4	0.6	-0.3	0.1	0.3	0.1	-0.2
Worry too long after embarrassment	0.6	1.1	3.8	-0.8	-1.9	0.6	0.5	1.2	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.4	1.3	-1.0	-0.0	-1.0	1.6	-1.3
Wheeze or whistling in the chest in last year	1.0	1.7	4.2	-1.1	0.4	2.0	0.9	-0.2	-2.1
Number of children fathered	0.9	1.1	2.6	0.9	-0.0	-1.1	1.6	1.3	0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.4	0.1	1.8	-1.9	-0.1	-1.2	0.3
Age at first live birth	0.4	0.7	2.1	0.1	0.3	-1.4	0.3	0.1	1.4
Pulse wave peak to peak time	1.5	1.8	5.2	0.6	2.3	-0.2	0.9	-1.4	1.5
Health satisfaction	0.9	1.2	4.7	-1.6	-2.2	0.3	-0.1	0.1	-0.1
Shortness of breath walking on level ground	0.6	0.7	1.8	0.0	-1.3	-1.3	-0.8	-0.4	0.1
Qualifications: College or University degree	0.2	0.6	1.4	0.4	-0.3	-0.3	1.2	-1.0	-0.8
Eye problems/disorders: None of the above	0.6	0.7	1.7	-0.5	-0.1	-1.1	1.3	-0.8	0.5
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.7	1.2	0.8	0.8	1.9	-0.4	-1.0
Emphysema/chronic bronchitis	1.5	1.7	4.3	-0.4	2.1	-1.7	1.2	-1.2	0.3
Medication for pain relief, constipation, heartburn	0.4	0.7	1.7	-0.7	0.1	0.4	1.3	-0.8	-1.2
Neck or shoulder pain in last month	1.9	2.7	4.9	-1.1	-1.7	1.7	-2.0	0.3	-2.2
Medication: Blood pressure	0.9	1.5	4.3	-2.1	0.0	-1.1	0.9	-1.7	-0.1
Angina (self-reported)	0.8	1.1	4.1	1.2	0.4	-2.0	0.1	-0.2	0.8
Migraine (self-reported)	0.3	0.4	1.1	0.5	-1.1	-0.4	0.2	-0.1	0.9
Medication: Ibuprofen	1.6	1.9	6.4	1.7	-0.8	-0.0	-0.1	2.5	1.3
Medication: Allopurinol	0.4	0.6	2.1	-0.4	-1.0	-1.5	0.4	-0.1	-0.0
Medication: Omeprazole	1.4	1.6	3.7	-1.7	-1.3	-0.2	-1.9	-0.3	-1.1
Medication: Seretide 50 evohaler	1.2	1.4	7.2	0.2	0.9	0.5	2.7	-0.1	0.2
Mean time to correctly identify matches	0.5	1.0	4.6	-0.4	-0.3	-0.2	0.5	-1.0	-2.1
Heart disease (mother)	0.4	0.4	1.1	1.0	-0.0	0.3	0.8	-0.8	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	5.9	1.0	-0.5	0.8	0.8	2.4	0.1
Whole body fat mass	0.7	2.7	9.5	-0.7	-0.3	-3.1	1.1	-2.3	0.3
Leg fat mass (right)	0.7	2.8	8.8	-0.3	0.3	-3.0	1.3	-2.4	0.3
Arm predicted mass (right)	0.8	4.0	12.7	1.7	-0.7	-3.6	-0.3	1.2	2.5
Pulse rate, automated reading	0.3	0.9	2.0	-1.4	-0.2	0.9	-0.3	-0.8	-1.4
Alcohol intake frequency.	0.3	0.8	2.4	1.1	-0.6	-1.6	0.3	0.4	0.7
Comparative height size at age 10	0.5	2.7	6.0	2.0	-2.4	-2.0	-0.6	0.8	1.0
Number of full sisters	0.7	0.8	2.0	-0.5	1.3	0.2	1.4	-0.9	-0.7
Suffer from ‘nerves’	0.5	0.7	2.2	-0.4	1.0	-1.0	-0.0	1.5	0.0
Overall health rating	0.4	0.9	3.0	-1.7	-0.5	0.8	-0.3	-0.7	-0.8
Chest pain or discomfort	1.3	1.9	3.3	-1.0	1.6	1.8	1.2	-0.1	-1.7
Had major operations	0.9	1.1	3.3	1.8	0.3	0.3	0.2	1.7	-0.2
Age at last live birth	0.2	0.3	1.1	0.2	-1.0	0.2	0.0	-0.0	0.6
Family relationship satisfaction	2.0	2.4	4.6	1.6	-2.0	-0.4	0.1	2.1	1.8
Leg pain on walking	1.5	1.9	6.0	-0.9	-1.6	-0.0	-2.5	1.4	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.8	-0.4	0.2	-0.6	0.3	0.3	-1.4
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.2	0.3	-1.5	-1.4	-0.5	-0.9	0.8
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	5.3	0.9	1.4	-1.4	2.3	-0.6	-0.1
Medication: Aspirin	1.2	1.5	5.2	-1.3	0.5	-0.4	-1.1	-2.3	-0.7
Supplements: Vitamin C	0.7	0.9	3.4	-0.7	-0.4	1.0	0.0	0.5	-1.8
Knee pain experienced in last month	0.1	0.1	0.2	-0.4	-0.5	0.2	0.3	0.3	-0.3
Hypertension (Self-reported)	0.4	1.2	2.0	-1.4	-0.7	1.4	0.5	-0.7	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.1	0.1	-0.3	-0.6	-1.5	-0.9	0.0
Illnesses of father: Heart disease	0.4	0.5	1.6	1.3	0.4	0.3	0.5	0.9	0.2
Illnesses of siblings: Diabetes	0.4	0.5	0.9	-0.7	-0.8	0.8	0.6	0.3	-0.9
Smoking status: Previous	0.4	0.6	2.3	-0.1	0.2	0.2	-1.5	0.9	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.2	0.2	-1.3	-0.6	-1.6	1.8	0.9
Whole body fat-free mass	0.7	4.1	14.1	1.4	-0.7	-3.8	-0.9	1.2	2.4
Leg fat-free mass (right)	0.5	2.8	13.7	0.7	-0.5	-3.7	-0.1	0.3	1.6
Arm fat percentage (left)	0.9	3.5	7.8	-1.5	0.0	-2.6	2.0	-2.8	-0.1
Average weekly red wine intake	0.4	0.6	1.7	-0.1	0.7	-0.1	1.2	1.3	0.2
Handedness (chirality/laterality): Left-handed	1.3	1.6	5.7	-1.4	0.6	0.5	1.0	-2.4	0.6
Mood swings	0.9	1.6	5.0	-0.8	-2.2	0.2	-1.2	0.8	1.3
Loneliness, isolation	0.7	1.0	2.6	-0.6	-1.6	-1.6	-0.7	0.4	-0.4
Long-standing illness, disability or infirmity	1.1	1.7	4.0	-1.2	1.5	-2.0	0.2	-1.4	0.2
Ever had bowel cancer screening	0.9	1.0	4.1	0.0	-0.4	0.4	-0.8	-1.0	-2.0
Diabetes diagnosed by doctor	0.6	0.9	3.1	0.0	1.2	-1.8	-0.9	-0.5	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	-0.1	-0.0	0.5	0.7	0.2	-0.8
Friendships satisfaction	1.6	1.9	4.0	1.4	-1.2	-0.5	2.0	1.4	1.5
Qualifications: nursing, teaching	0.2	0.4	0.8	0.9	0.2	0.5	0.5	-0.2	0.9
Commuting to job workplace: Walk	0.7	0.8	2.3	-0.5	1.5	0.8	-0.0	1.1	-0.5
Eye problems/disorders: Cataract	1.1	1.2	2.3	1.5	0.1	1.4	-1.1	1.3	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.4	0.6	0.6	-0.6	0.6	-0.6	-0.5
Medication for cholesterol	0.2	0.4	1.0	-0.3	0.6	-0.1	0.5	1.0	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.6	0.8	-0.2	-1.2	1.3	-0.4	1.0
Back pain experienced in last month	1.0	1.4	4.2	-1.0	-1.3	2.0	-0.2	1.4	0.0
Mineral and other dietary supplements	1.1	1.5	3.0	-1.3	-1.7	-1.6	0.5	-0.7	1.0
Breast cancer (self-reported)	1.2	1.5	3.7	1.9	-0.8	-0.7	-0.7	1.8	0.5
Asthma (self-reported)	0.5	1.0	5.1	0.1	-0.1	0.5	0.3	-0.7	-2.2
Osteoporosis (self-reported)	1.4	1.7	7.3	-2.7	0.6	-0.7	0.1	-1.3	-0.2
Osteoarthritis (self-reported)	1.0	1.3	3.7	1.3	0.9	-1.9	0.6	-0.3	1.0
Medication: Aspirin	0.8	1.1	5.3	-0.6	0.3	0.3	-0.5	-2.3	-0.5
Medication: Gliclazide	1.3	1.5	4.3	-2.1	0.3	-0.7	-1.5	-1.3	-0.4
Illnesses of father: None of the above (group 1)	0.6	0.8	2.8	-0.8	0.3	-0.3	-1.7	0.8	0.4
Smoking status: Current	0.9	1.5	5.4	-0.7	2.3	0.6	0.1	-1.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.8	5.8	16.8	3.1	0.0	-1.8	1.8	1.4	4.1
Whole body water mass	0.7	4.2	15.0	1.5	-0.5	-3.9	-0.8	1.2	2.4
Leg predicted mass (right)	0.5	2.7	13.3	0.7	-0.6	-3.6	-0.1	0.4	1.5
Arm fat mass (left)	0.6	2.5	9.3	-0.5	-0.4	-3.0	1.3	-1.7	0.8
Number of self-reported non-cancer illnesses	0.6	1.1	3.2	-0.7	0.2	-1.0	-1.8	-0.4	-1.2
Average weekly champagne plus white wine intake	0.8	1.1	2.5	-1.5	-1.1	0.5	0.3	0.3	-1.6
Miserableness	0.5	0.9	2.5	-1.0	-1.6	-0.2	-0.8	1.2	0.2
Guilty feelings	2.2	3.2	11.1	-1.5	-1.9	-3.3	-0.5	-1.4	0.5
Wears glasses or contact lenses	2.4	2.8	10.7	-1.1	-0.7	-0.2	-0.5	-2.0	-3.3
Ever taken oral contraceptive pill	0.5	0.5	1.5	-0.4	-0.6	0.6	-0.9	-0.2	-1.2
Hearing aid user	1.4	1.6	3.0	0.2	0.9	-1.4	1.7	0.7	1.7
Mother’s age at death	0.8	1.0	3.3	-0.7	0.8	-0.7	-0.3	-1.8	0.8
Financial situation satisfaction	0.4	0.6	1.5	-0.3	-0.1	0.5	-1.2	0.6	1.1
Tinnitus: Yes, now most or all of the time	1.6	1.9	8.2	0.3	2.9	-0.6	0.4	-0.7	-1.5
Commuting to job workplace: Public transport	0.8	1.0	2.2	-1.5	1.1	-0.3	0.7	-1.0	-0.9
Eye problems/disorders: Glaucoma	1.2	1.4	3.3	-0.2	-0.8	1.2	-1.5	1.8	-0.9
Medication: Blood pressure	0.4	0.7	2.2	-0.7	-0.5	1.1	0.1	-1.5	-0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.6	-0.2	-0.5	-0.6	-1.2	0.6	0.6
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.8	1.4	1.6	1.7	0.5	0.4	-1.0
High cholesterol (Self-reported)	0.7	1.2	3.2	0.0	0.1	-1.5	-1.8	-1.4	-0.3
Medication: Bendroflumethiazide	0.6	0.9	2.9	-1.2	-0.6	0.2	0.1	-1.7	-0.6
Medication: Paracetamol	1.0	1.5	5.3	-0.5	-0.4	1.2	-2.3	0.9	1.2
Medication: Lisinopril	1.7	2.2	4.0	-0.7	1.4	-2.0	0.7	-1.9	1.6
Medication: Atorvastatin	2.0	2.5	5.4	-0.7	-1.0	0.4	-2.3	-2.3	-1.6
Illnesses of father: High blood pressure	0.6	0.7	2.8	-0.9	0.6	0.5	1.7	-0.0	0.5
Alcohol drinker status: Never	1.5	1.7	3.9	-0.4	-1.3	2.0	-0.7	0.8	-1.9
Ever smoked	0.8	1.4	3.8	0.6	-0.1	1.5	-1.1	0.6	-1.9
Basal metabolic rate	0.7	3.7	14.9	1.1	-0.7	-3.9	-0.6	0.7	2.2
Leg fat percentage (left)	0.6	2.1	5.9	-0.5	0.5	-2.1	1.4	-2.4	-0.2
Arm fat-free mass (left)	0.8	4.1	13.6	1.6	-0.5	-3.7	-0.8	1.0	2.5
Number of operations (self-reported)	0.6	0.9	1.9	1.4	0.4	1.1	1.0	1.1	-0.5
Average weekly beer plus cider intake	0.3	0.5	1.2	1.1	0.4	0.5	-0.5	-0.4	1.0
Irritability	2.6	4.4	18.1	-1.5	-4.2	1.0	-1.7	0.7	-1.3
Risk taking	0.6	0.8	3.2	0.4	-0.4	1.8	-0.6	0.7	-0.6
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.1	-0.6	-1.0	0.3	-0.5	-0.7	0.6
Fractured/broken bones in last 5 years	0.7	0.9	2.7	-0.3	0.6	1.6	1.3	0.1	-0.6
Age started oral contraceptive pill	0.3	0.4	1.9	0.2	0.1	0.2	1.4	-0.6	-0.5
Diastolic blood pressure, automated reading	1.1	3.5	11.6	0.7	-0.3	0.6	3.4	2.9	-0.2
Ever depressed for a whole week	0.8	1.0	3.0	-1.2	-0.8	1.7	-0.3	-0.0	-1.0
Unable to work because of sickness or disability	0.7	0.9	2.8	-1.4	0.3	-0.5	-0.0	-1.7	-0.2
Commuting to job workplace: Cycle	0.5	0.6	1.2	-1.1	-0.0	1.0	1.1	-0.0	-0.6
Myopia	1.1	1.6	7.1	0.4	-1.2	-0.8	-2.7	0.4	0.1
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.1	1.6	0.5	-1.2	0.2	1.0	1.7
Cholesterol lowering medication	0.2	0.3	0.8	0.7	-0.2	-0.2	-0.9	-0.6	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.0	-1.4	-0.8	-0.8	-1.1	0.1	-0.6
Pain experienced in last month	1.0	1.6	3.1	1.6	0.8	-1.3	1.8	0.4	1.2
Supplements: Calcium	0.3	0.3	1.1	-0.7	1.1	0.2	-0.1	0.2	-0.3
Basal cell carcinoma (self-reported)	0.6	0.7	2.4	-1.6	0.2	-0.5	-0.8	-1.1	-0.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	3.8	-0.4	-0.3	-2.0	0.5	-0.4	0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.5	-1.2	0.6	-0.6	0.1	-0.2	0.4
Heart disease (siblings)	1.9	2.4	10.5	0.4	3.2	-0.9	0.8	-0.7	1.3
Alcohol drinker status: Previous	0.5	0.6	1.5	1.2	0.4	-1.2	-0.5	-0.2	-0.3
Pack years of smoking	1.1	1.6	4.7	-1.8	0.2	0.5	-0.2	-1.1	-2.2
Impedance of whole body	0.6	2.9	7.4	-1.9	-1.2	2.7	0.0	-1.4	-1.8
Leg fat mass (left)	0.6	2.5	8.7	-0.1	0.4	-3.0	1.3	-2.0	0.4
Arm predicted mass (left)	0.9	4.4	13.8	1.7	-0.4	-3.7	-0.6	1.2	2.8