Hub : Genes

MTA3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.1518 0.0651 0.00310 0.010 NA 0.015 NA 0.027 0.130 NA 0.094 NA 0.038
2 GTEx Cells EBV-transformed lymphocytes 0.3450 0.1110 0.00018 0.002 NA 0.037 NA -0.003 0.270 NA 0.024 NA 0.410
3 GTEx Cells Transformed fibroblasts 0.0940 0.0430 0.00530 -0.003 NA 0.003 NA -0.002 0.720 NA 0.180 NA 0.470
4 GTEx Skin Not Sun Exposed Suprapubic 0.1440 0.0590 0.00380 0.004 NA 0.011 NA 0.015 0.190 NA 0.079 NA 0.046
5 GTEx Spleen 0.4000 0.1020 0.00065 -0.009 NA 0.016 NA 0.021 0.660 NA 0.130 NA 0.092
6 YFS Blood 0.0157 0.0074 0.00093 0.004 0.008 0.000 0.007 0.003 0.018 0.0012 0.220 0.0016 0.036

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.8 1.2 3.1 0.8 0.7 -0.2 1.0 1.8 -1.4
Bipolar Disorder or Schizophrenia 0.5 1.2 2.0 0.5 -0.0 -1.4 1.2 1.3 -1.3
Depressed Affect (Nagel 2018) 0.8 1.7 6.5 2.5 -1.3 -0.1 0.2 -1.4 0.2
Depression (Nagel 2018) 0.8 1.2 2.6 1.6 -1.6 0.6 1.0 -0.8 0.4
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.3 0.3 0.1 -0.5 -1.1 -1.1 0.2
Neuroticism (Nagel 2018) 1.0 2.3 4.5 1.7 -2.0 -1.0 -0.8 -2.1 1.0
Schizophrenia (2018) 0.3 0.7 2.8 -0.0 -0.6 -1.7 0.7 0.2 -0.6
Schizophrenia vs Biploar Disorder 2.1 2.8 5.5 -1.3 -1.5 -1.8 -1.2 -2.3 1.5
Worry (Nagel 2018) 0.2 0.4 0.9 0.3 -0.6 -0.9 -0.6 -1.0 -0.1
Alzheimer’s Disease (in mother) 1.8 2.1 4.1 -0.7 -1.0 0.7 -2.0 -1.6 2.0
Alzheimer’s Disease (in father) 1.1 1.2 3.0 -1.5 0.8 0.7 0.8 1.7 0.0
Alzheimer’s Disease (including proxy) 0.6 0.9 3.7 -0.9 0.7 1.9 -0.5 0.3 0.5
Crohns Disease (2017) 0.4 0.9 1.5 -0.8 0.2 0.9 -1.2 -1.1 1.0
Irritable Bowel Disease (IBD) 0.1 0.3 1.1 -0.2 1.0 0.7 -0.1 -0.6 -0.3
Ulcerative Colitis (UC) 0.2 0.4 1.0 0.1 1.0 0.0 0.5 -0.3 -0.9
Major Depression (MDD) 3.5 4.3 9.4 -0.7 -1.0 -2.2 -2.3 -3.1 2.1
Reaction Time 2.7 5.2 9.9 -2.5 -1.7 -1.9 -1.4 -3.1 2.5
Verbal and Numeric Reasoning (VNR) 0.3 0.6 1.4 0.7 0.5 -0.5 -0.3 -1.1 -1.2
Breast Cancer 0.8 2.0 5.1 0.1 0.7 1.5 -1.3 1.5 -2.3
Ovarian Cancer 1.0 1.3 5.5 2.3 0.0 1.1 0.4 -0.6 -0.7
Prostate Cancer 1.3 1.9 3.5 -1.1 1.7 0.9 0.8 1.9 -1.5
Age at First Birth 0.6 0.9 1.9 0.3 0.1 -0.7 1.0 1.3 -1.4
Bipolar Disorder (2011) 1.9 1.8 3.4 1.8 -0.1 -1.4 1.6 1.0 -1.3
Body Mass Index (BMI) (2010) 4.4 6.0 10.3 -0.6 -2.1 -2.1 -2.5 -3.2 3.2
Coronary Artery Disease (CAD) 1.4 1.6 7.0 0.1 -1.1 -2.6 -0.6 -0.7 0.7
Crohns Disease (2012) 1.0 1.5 4.0 -2.0 -0.3 1.3 -1.4 -0.7 1.1
Mean Putamen Volume 0.2 0.2 0.4 0.1 0.6 0.5 0.5 -0.7 -0.0
Fasting Glucose 2.8 3.3 5.2 0.3 2.2 1.9 1.4 2.1 -2.3
HbA1C 1.5 1.7 2.8 1.7 0.8 1.5 1.0 -1.2 -1.4
HDL Cholesterol 0.4 0.7 0.9 0.8 0.5 0.9 0.8 0.9 -0.8
LDL Cholesterol 0.8 1.3 4.6 -1.1 0.7 -0.0 -1.2 -2.1 0.5
Lupus 0.3 0.4 1.0 0.9 1.0 0.3 -0.5 0.3 0.1
Neuroticism (2016) 1.2 1.7 4.4 2.1 -0.9 -0.9 1.7 -1.0 0.4
Primary Biliary Cirrhosis 1.0 1.4 2.9 1.1 0.2 1.2 1.7 1.4 -0.7
Rheumatoid Arthritis 0.5 0.6 1.0 1.0 -0.7 0.1 1.0 0.6 -0.9
Schizophrenia (2014) 0.4 0.9 2.3 0.5 -0.1 -1.5 1.3 0.4 -1.1
Triglycerides 1.3 2.2 4.2 -2.1 -0.1 -1.4 -1.6 -1.5 1.4
Type 2 Diabetes (T2D) (2012) 0.1 0.2 0.4 0.5 0.2 0.1 -0.6 0.3 0.5
Ulcerative Colitis 0.4 0.6 2.2 -0.2 1.5 0.5 0.9 0.3 -0.4
Blood Eosinophil Count 0.2 1.9 3.8 -0.5 1.8 1.3 1.9 0.8 -1.3
Blood Platelet Count 0.4 4.2 11.4 -1.1 -0.6 2.5 -0.7 -2.4 3.4
Blood Red Count 0.4 3.4 6.1 -2.5 0.2 -2.4 -1.4 -2.3 1.3
Blood White Count 1.0 7.7 15.9 0.7 3.6 2.1 3.3 1.1 -4.0
Heel T-Score 3.0 24.2 62.7 3.7 7.3 -3.7 1.2 -0.5 -7.9
BMI 1.5 8.6 23.7 -1.1 -2.9 -4.9 -1.7 -1.6 3.6
Height 0.4 7.9 27.4 2.0 1.8 0.9 2.9 5.2 -1.9
Waist Hip Ratio (WHR) 0.8 3.5 9.7 2.5 -1.6 -0.4 1.1 -3.1 1.1
Systolic Blood Pressure 1.3 6.6 16.8 -0.9 -0.1 -3.7 2.6 0.9 -4.1
Smoking Status 0.6 1.3 4.2 0.3 1.4 2.0 0.8 0.3 -1.0
Allergy or Eczema 0.3 0.8 3.8 0.5 1.9 0.3 0.4 0.5 -0.3
Cardiovascular Disease 1.1 3.7 18.3 -0.7 -0.0 -4.3 0.4 0.1 -1.9
Hypothyroidism (self reported) 0.6 1.3 2.6 0.8 1.4 1.6 1.0 0.9 -1.0
Respiratory disease 1.8 3.9 12.1 -3.5 1.9 -0.8 -1.6 -0.6 2.0
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.9 0.1 -1.0 -0.3 0.8 -0.1 -0.2
Lung FEV1/FVC ratio 6.8 34.4 46.8 5.0 6.8 6.7 0.5 6.8 -6.7
Lung FVC 0.4 1.9 3.9 2.0 -0.2 -0.1 -2.0 0.8 -1.6
Neuroticism 0.8 1.9 2.9 1.0 -1.7 -1.4 -1.2 -1.4 1.4
Chronotype (morning person) 0.7 1.5 3.6 0.6 1.0 1.9 1.6 1.1 -0.7
Hair Pigment 0.0 1.1 2.9 -1.7 -0.8 0.7 -1.0 1.2 0.4
Tanning 0.8 9.4 14.6 0.7 3.3 3.1 2.7 3.7 -3.8
Hand grip strength (left) 1.3 3.5 7.2 0.4 1.7 -2.3 1.6 2.7 -1.8
Number of treatments/medications taken 0.2 0.4 0.8 0.9 0.1 -0.8 0.6 -0.2 -0.8
Average weekly spirits intake 2.8 3.4 9.9 -0.1 3.1 1.1 1.1 1.5 -2.4
Sensitivity / hurt feelings 1.3 2.2 5.6 1.4 -2.4 -1.0 -0.9 -0.9 1.8
Frequency of depressed mood in last 2 weeks 0.8 1.1 4.5 0.9 -1.1 0.3 0.1 -2.1 0.3
Hearing difficulty/problems: Yes 1.6 2.4 7.3 -0.1 -1.8 -1.0 -1.4 -1.2 2.7
Relative age of first facial hair 1.0 2.0 6.5 0.5 -1.5 -2.5 -0.3 -1.8 0.1
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.1 1.1 -0.2 0.3 -0.4 -0.9 0.7
Ever used hormone-replacement therapy (HRT) 0.9 1.1 2.8 -0.3 -0.4 -0.9 -0.9 -1.4 1.7
Ever had hysterectomy (womb removed) 0.4 0.5 1.3 0.0 1.1 0.1 1.0 0.2 -0.6
Systolic blood pressure, automated reading 0.2 0.5 1.2 -1.1 0.0 -0.9 -0.0 -0.1 -0.9
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.8 -0.3 -0.8 -0.5 -0.7 -1.3 0.6
Angina 0.8 1.1 4.8 -0.9 -0.1 -2.2 -0.4 -0.0 0.7
Medication for hormone replacement therapy 0.7 0.8 2.9 -0.8 -0.7 -1.7 -0.5 0.4 0.5
Vitamin and mineral supplements 2.3 3.2 6.4 -1.9 -2.0 -2.5 -1.2 -0.5 1.7
Supplements: Zinc 0.9 0.9 1.8 1.0 0.9 1.2 -0.4 0.8 -1.3
Medication: Co-codamol 0.3 0.4 0.6 0.7 0.8 -0.7 0.5 -0.7 -0.1
Medication: Metformin 0.9 1.3 2.4 -1.0 -1.5 0.9 0.0 -1.4 1.2
Diabetes (father) 1.5 1.9 6.2 1.0 -2.5 0.1 2.0 0.0 0.3
Diabetes (mother) 0.9 1.1 2.3 1.3 0.4 1.1 0.6 0.9 -1.5
Severe depression (siblings) 0.6 0.7 1.4 -0.6 -1.2 -0.3 -1.2 -0.3 1.0
Pack years adult smoking proportion 0.3 0.5 1.3 -0.3 -0.8 -0.6 0.3 -0.6 1.1
Impedance of leg (right) 0.1 0.6 2.0 -0.5 -1.4 0.2 0.4 -1.1 -0.2
Leg fat-free mass (left) 0.2 0.9 2.6 0.8 -0.3 -1.5 0.2 1.6 0.3
Trunk fat percentage 2.4 9.5 18.2 1.1 -3.9 -2.2 -2.2 -4.3 3.5
Hand grip strength (right) 1.1 3.1 6.7 0.1 1.7 -1.5 2.2 2.6 -1.5
Townsend deprivation index at recruitment 0.9 1.3 3.0 -0.8 -1.1 -1.7 -0.7 -1.2 0.9
Current tobacco smoking 0.1 0.2 0.8 -0.1 -0.3 -0.1 0.9 0.2 -0.2
Average weekly fortified wine intake 0.7 0.9 1.9 1.4 0.5 0.5 0.9 0.6 -1.3
Maternal smoking around birth 0.7 1.0 3.5 1.0 0.1 -0.2 0.6 1.1 -1.9
Fed-up feelings 1.8 3.3 9.4 1.4 -2.0 -0.7 -1.1 -3.1 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 2.5 1.0 -1.6 -0.8 0.8 -1.6 0.7
Relative age voice broke 1.4 2.1 3.9 1.0 -0.7 -1.9 1.8 -0.3 -2.0
Taking other prescription medications 1.6 2.5 5.5 1.2 -2.0 -0.9 0.9 -2.3 1.6
Age when periods started (menarche) 0.7 1.6 5.9 1.8 -2.4 -0.5 0.8 0.0 -0.0
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.8 -0.7 -0.9 0.0 -0.5 -0.9 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.2 8.3 1.6 0.8 -2.0 0.7 -1.7 -2.9
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.2 1.1 -0.8 -0.2 -0.1 0.2 0.1
Qualifications: CSEs or equivalent 0.5 0.7 1.4 1.0 0.2 0.8 0.9 1.2 -0.5
Serious illness, injury or assault to yourself 0.6 0.7 1.3 0.6 0.9 0.7 0.5 1.0 -1.1
High blood pressure 0.7 1.9 5.6 0.2 0.0 -2.4 1.0 -0.0 -2.1
Hayfever, allergic rhinitis or eczema 0.4 0.9 3.2 1.0 1.8 0.0 0.3 0.4 -1.0
Multivitamins +/- minerals 3.4 4.3 9.6 1.4 2.5 3.1 0.7 0.7 -2.6
Stomach or abdominal pain in last month 1.9 2.4 6.7 -2.4 -0.2 -1.0 -0.6 -2.6 0.8
Supplements: Glucosamine 3.5 4.5 9.5 2.6 1.8 0.9 2.2 1.5 -3.1
Diverticular disease/diverticulitis (self-reported) 3.4 4.1 6.8 -0.0 2.6 0.1 2.3 2.4 -2.5
Medication: Atenolol 2.2 2.7 9.4 -2.4 -0.2 -3.1 -1.1 -0.4 0.4
Medication: Levothyroxine sodium 1.3 2.3 7.7 0.9 1.6 2.8 0.7 1.0 -0.9
Sitting height 1.2 8.7 23.2 -4.8 0.0 -4.4 -0.0 3.0 0.1
Chronic bronchitis/emphysema (father) 4.1 4.8 10.6 -1.6 -0.7 -1.4 -3.3 -1.9 3.1
High blood pressure (mother) 0.9 1.3 6.3 -0.1 -0.7 -2.5 -0.1 -1.0 -0.4
Body mass index (BMI) 1.2 5.0 8.1 -0.6 -2.3 -2.9 -1.9 -2.2 2.8
Impedance of leg (left) 0.1 0.4 1.2 -0.3 -0.8 0.2 0.3 -1.1 -0.6
Leg predicted mass (left) 0.2 1.0 2.9 0.8 -0.2 -1.5 0.2 1.7 0.3
Trunk fat mass 1.3 5.6 10.0 1.0 -3.2 -2.3 -1.5 -2.6 2.9
Waist circumference 0.9 3.2 7.6 1.0 -2.8 -1.9 -0.4 -1.9 1.7
Number of incorrect matches in round 1.2 2.0 4.5 1.2 2.1 2.0 0.4 1.2 -0.5
Past tobacco smoking 0.9 1.6 5.2 0.0 -2.3 -1.8 0.3 0.2 1.0
Alcohol usually taken with meals 1.1 1.8 3.2 1.6 1.2 0.3 1.2 1.4 -1.8
Nervous feelings 1.6 2.9 5.5 -1.0 -2.0 -1.6 -1.6 -2.4 1.4
Frequency of tenseness / restlessness in last 2 weeks 1.8 2.8 9.4 0.0 -1.2 -1.8 -0.7 -3.1 1.5
Hearing difficulty/problems with background noise 0.7 1.2 3.6 -0.1 -0.7 -0.3 -1.4 -1.0 1.9
Hair/balding pattern: Pattern 2 0.7 0.9 2.1 -0.8 1.1 1.5 0.7 0.3 1.0
Had menopause 1.1 1.3 2.9 -0.4 0.3 1.5 -0.9 -1.4 1.7
Had other major operations 0.9 1.1 3.2 0.9 -1.8 -0.4 0.5 -1.4 0.6
Forced vital capacity (FVC) 0.4 1.6 4.1 0.7 -0.1 -1.1 -0.7 2.0 -1.9
Heel bone mineral density (BMD) T-score, automated (right) 1.7 3.9 8.4 1.4 1.1 -2.4 -0.0 -2.4 -2.9
Ever unenthusiastic/disinterested for a whole week 1.0 1.3 3.9 1.3 -2.0 -1.2 0.7 -0.2 0.3
Qualifications: None of the above 0.1 0.2 0.5 -0.5 -0.2 0.6 -0.7 -0.3 0.3
Financial difficulties in last 2 years 2.3 3.1 10.9 1.0 -3.3 -1.5 0.4 -1.9 0.7
Mouth/teeth dental problems 1.3 2.0 5.4 0.4 1.2 1.2 1.3 2.3 -1.3
Heart attack 1.4 1.8 6.8 -1.8 0.1 -2.6 -0.5 -0.3 0.6
Allergy 0.4 1.0 4.9 -0.3 -2.2 -0.5 -0.4 -0.7 0.0
Pain all over the body in last month 1.1 1.1 3.0 1.7 -0.3 -0.2 1.0 -0.5 -1.6
Diabetes (self-reported) 0.3 0.5 1.6 -0.5 -1.3 -0.3 -0.5 -0.8 0.6
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.3 1.1 0.9 0.2 -0.0 0.9 -0.7
Medication: Ramipril 2.1 2.7 5.3 -0.9 0.8 -2.0 2.0 1.2 -2.3
Medication: Simvastatin 1.8 2.7 8.2 -2.2 -0.7 -2.9 -1.4 -0.6 0.7
Fluid intelligence score 0.8 1.6 2.9 -1.3 0.8 -1.3 -1.6 -1.7 0.2
Illnesses of siblings 0.9 1.2 3.1 1.1 1.8 1.4 0.5 0.8 -0.5
Neuroticism score 1.7 3.5 6.6 0.2 -2.4 -1.8 -1.9 -2.6 1.5
Weight 0.4 1.8 6.2 -0.2 -1.5 -2.5 -0.6 -0.1 1.5
Impedance of arm (right) 1.3 6.1 17.2 3.1 -2.6 1.6 -0.4 -4.2 0.8
Arm fat percentage (right) 2.3 9.1 18.9 1.5 -3.6 -2.1 -2.3 -4.3 3.4
Trunk fat-free mass 1.0 5.8 23.5 -0.0 1.9 -0.8 1.8 4.8 -2.1
Hip circumference 0.3 1.3 3.4 0.2 -1.8 -1.9 -1.0 0.1 0.8
Time employed in main current job 0.3 0.3 1.1 -0.2 -0.1 -0.4 0.8 -1.1 0.0
Alcohol intake versus 10 years previously 0.7 1.0 2.9 -1.0 -1.3 -1.7 0.4 0.1 -0.5
Father’s age at death 1.5 2.0 6.0 2.2 0.9 2.4 0.7 0.1 -0.3
Worrier / anxious feelings 0.2 0.4 1.7 0.6 -0.4 0.0 0.4 1.3 -0.4
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.1 6.5 -0.5 -0.7 -1.3 -1.3 -2.5 1.5
Falls in the last year 1.0 1.3 3.5 0.2 -1.8 0.8 -0.4 -1.9 0.5
Hair/balding pattern: Pattern 3 0.2 0.3 0.9 0.4 0.6 -1.0 0.1 -0.5 -0.3
Number of live births 0.6 0.8 3.1 -0.9 0.0 0.6 -1.8 0.3 0.6
Forced expiratory volume in 1-second (FEV1) 1.5 5.0 12.2 2.1 1.4 0.4 -0.6 3.5 -3.3
Pulse rate 0.4 0.7 1.5 -1.1 -1.0 -0.4 -0.2 -1.2 0.4
Happiness 1.4 1.7 2.6 1.4 -1.6 -1.6 -0.7 -1.2 1.1
Noisy workplace 0.4 0.5 1.8 -1.4 0.3 0.4 0.8 -0.4 -0.1
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.1 0.6 0.2 0.0 -0.4 1.0 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 1.0 -0.7 -0.2 -0.3 0.6 -1.0 0.3
Mouth/teeth dental problems: Dentures 0.6 1.0 3.9 -1.0 0.0 -0.8 -0.2 -2.0 0.7
Asthma 1.1 2.3 5.8 -2.4 1.3 -0.3 -0.9 -1.6 1.7
Medication: Ibuprofen (e.g. Nurofen) 2.7 3.5 7.5 2.7 1.5 1.7 1.0 1.9 -1.9
Medication: Cholesterol lowering 0.7 1.1 3.5 -1.4 -0.8 -1.9 -0.1 0.4 0.6
Depression (self-reported) 0.7 0.8 3.9 0.3 -0.3 0.5 -0.4 -2.0 0.5
Medication: Lansoprazole 0.1 0.1 0.3 0.0 -0.3 -0.4 0.1 -0.6 0.3
Prospective memory result 1.8 2.2 6.4 0.8 1.9 2.5 0.2 1.0 -1.1
Lung cancer (father) 3.8 4.4 10.8 -2.2 -1.0 -1.1 -3.3 -2.4 1.7
Illnesses of mother 3.1 3.8 12.6 2.5 0.4 3.5 0.9 1.0 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.6 14.3 2.0 1.1 0.6 0.8 3.6 -3.8
Pulse wave Arterial Stiffness index 2.8 3.3 8.4 -0.3 2.9 1.6 1.1 1.3 -2.4
Impedance of arm (left) 1.3 6.1 18.6 2.6 -2.8 1.5 -0.5 -4.3 1.0
Arm fat mass (right) 1.3 5.2 8.3 0.9 -2.9 -2.5 -1.5 -2.4 2.8
Trunk predicted mass 1.0 5.7 22.8 0.1 1.8 -0.8 1.8 4.8 -2.1
Standing height 0.7 7.3 24.2 0.9 1.9 0.5 2.7 4.9 -2.6
Length of working week for main job 2.1 2.3 5.2 -2.3 -0.5 -0.8 -1.6 -1.9 1.1
Exposure to tobacco smoke at home 0.2 0.2 0.8 -0.9 -0.2 -0.0 0.8 -0.1 -0.2
Breastfed as a baby 1.2 1.5 2.9 -0.8 1.6 -0.2 1.2 1.7 -1.1
Tense / ‘highly strung’ 0.8 1.2 2.8 -0.9 -0.3 -1.7 -1.3 -1.3 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.1 5.1 2.0 -1.6 -0.7 0.0 -2.3 0.7
Hair/balding pattern: Pattern 4 0.1 0.3 1.2 1.1 -0.3 0.7 -0.4 0.2 -0.0
Birth weight of first child 0.2 0.4 1.2 0.6 -0.4 -0.5 -0.6 -0.1 1.1
Peak expiratory flow (PEF) 3.5 8.1 14.2 2.5 3.5 1.4 1.0 3.8 -3.7
Pulse wave reflection index 1.2 1.5 4.2 1.2 1.2 -0.7 0.8 0.9 -2.0
Ever highly irritable/argumentative for 2 days 0.9 1.1 4.8 0.3 -0.9 -0.4 -0.6 -2.2 0.8
Loud music exposure frequency 0.3 0.4 0.9 -0.7 0.2 1.0 -0.2 0.7 -0.3
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 3.9 1.0 -0.8 -1.1 0.5 2.0 -0.7
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.0 0.3 -0.5 -0.4 -1.0 -0.4 0.0
Blood clot in the leg (DVT) 0.9 1.2 3.0 0.7 0.5 1.7 0.6 1.6 0.3
Medication: Paracetamol 1.8 3.0 9.0 3.0 2.2 0.8 -1.0 1.4 -0.9
Headache pain in last month 0.5 0.9 4.8 2.2 -0.4 -0.3 -0.2 -0.4 0.2
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.6 1.2 0.2 1.0 -0.2 -0.8 0.5
Glaucoma (self-reported) 2.2 2.6 4.8 2.2 1.3 1.4 1.9 1.2 -1.4
Gout (self-reported) 0.3 0.4 1.2 -0.4 -0.8 0.3 1.1 0.0 -0.6
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 8.1 1.0 1.2 2.8 0.8 0.0 -0.9
Medication: Amlodipine 0.8 1.2 2.1 -1.4 1.4 -0.2 1.1 -0.2 -1.3
Medication: Ventolin 100micrograms inhaler 1.5 1.9 5.0 -0.8 -1.4 -1.1 0.1 -2.2 1.7
Birth weight 1.8 4.0 11.6 0.0 -2.5 -0.2 -1.5 -1.9 3.4
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.0 -1.2 1.4 -1.1 -0.6 0.4 0.0
High blood pressure (siblings) 1.4 2.1 6.2 0.3 -2.5 -2.1 0.8 -0.8 -0.7
Forced vital capacity (FVC), Best measure 0.8 2.8 7.8 1.1 -0.2 -0.8 1.2 2.4 -2.8
Body fat percentage 2.5 10.1 18.1 0.5 -4.0 -2.5 -2.4 -4.3 3.7
Leg fat percentage (right) 2.5 9.1 14.7 -0.8 -3.8 -2.6 -2.4 -3.6 3.7
Arm fat-free mass (right) 0.8 4.2 17.6 -1.1 1.4 -1.6 0.9 4.2 -1.0
Exposure to tobacco smoke outside home 1.0 1.3 3.8 1.0 -0.3 -1.0 -0.6 -1.9 1.3
Comparative body size at age 10 0.7 1.8 3.8 -1.4 -1.3 -1.9 -0.9 -0.9 1.4
Number of full brothers 0.8 1.0 2.2 -0.8 -0.5 -0.5 -1.5 -0.9 1.4
Worry too long after embarrassment 3.2 5.4 8.6 -1.2 -1.9 -2.7 -2.9 -2.3 2.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.1 4.4 2.1 1.6 0.1 1.7 0.2 -1.6
Wheeze or whistling in the chest in last year 1.1 1.9 3.9 -1.7 0.0 -0.9 -0.4 -1.9 2.0
Number of children fathered 1.8 2.1 4.6 -0.3 1.9 0.4 1.4 2.1 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.9 0.9 0.5 0.0 0.6 1.3 -1.4
Age at first live birth 0.4 0.7 2.0 -0.1 -0.1 0.2 1.3 1.4 -0.6
Pulse wave peak to peak time 2.5 3.0 8.1 0.4 -2.8 -1.5 -1.0 -1.0 2.3
Health satisfaction 2.2 2.9 5.0 -0.6 -2.1 -1.4 -1.0 -2.1 2.2
Shortness of breath walking on level ground 0.1 0.1 0.3 0.3 -0.3 0.5 0.5 -0.0 0.0
Qualifications: College or University degree 0.3 0.9 3.0 0.5 1.3 -0.2 0.6 -0.1 -1.7
Eye problems/disorders: None of the above 1.5 1.7 6.5 -2.6 1.0 -0.1 -1.6 0.7 -0.2
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.0 -1.4 0.7 1.0 -0.1 -0.2 0.6
Emphysema/chronic bronchitis 0.8 0.9 3.0 0.9 1.0 1.7 0.1 0.9 -0.0
Medication for pain relief, constipation, heartburn 0.8 1.4 4.2 -2.0 -1.7 0.4 0.3 -0.9 0.6
Neck or shoulder pain in last month 0.8 1.2 3.9 -0.2 -1.1 -0.4 -0.0 -2.0 1.3
Medication: Blood pressure 0.5 0.9 2.7 -0.9 -0.0 -1.1 0.7 0.5 -1.6
Angina (self-reported) 1.0 1.3 6.5 -0.9 -0.3 -2.5 -0.2 -0.2 0.7
Migraine (self-reported) 0.4 0.4 1.1 0.8 0.3 -1.0 -0.8 -0.1 0.3
Medication: Ibuprofen 2.0 2.4 4.2 1.9 1.5 0.9 1.0 1.6 -2.0
Medication: Allopurinol 0.1 0.2 0.6 -0.2 -0.5 0.0 0.8 -0.2 -0.3
Medication: Omeprazole 0.7 0.8 2.8 -0.8 -0.1 -0.0 -0.8 -0.9 1.7
Medication: Seretide 50 evohaler 0.4 0.4 1.6 -0.4 0.3 0.4 1.3 -0.5 -0.5
Mean time to correctly identify matches 1.2 2.3 4.5 -2.1 -0.4 -0.8 -1.0 -1.9 2.0
Heart disease (mother) 1.4 1.7 6.2 -1.7 -0.1 -2.5 -0.7 -0.4 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 1.6 0.7 -0.8 -0.6 -1.3 -1.1 1.1
Whole body fat mass 1.3 5.4 9.3 0.4 -3.0 -2.6 -1.5 -2.5 2.9
Leg fat mass (right) 1.6 6.4 10.7 -0.6 -3.3 -2.9 -1.8 -2.4 3.1
Arm predicted mass (right) 0.7 3.8 14.7 -1.0 1.3 -1.8 1.0 3.8 -1.0
Pulse rate, automated reading 0.6 2.0 9.4 -3.1 0.1 -0.5 -0.9 0.1 1.2
Alcohol intake frequency. 1.4 3.2 6.5 0.4 -2.4 -1.0 -0.5 -2.5 2.3
Comparative height size at age 10 0.9 5.2 9.5 1.9 2.6 2.3 1.7 3.1 -1.7
Number of full sisters 1.1 1.4 3.1 -0.9 -1.8 0.5 -0.6 -0.9 1.7
Suffer from ‘nerves’ 0.7 1.1 2.5 0.4 -1.1 -1.6 0.2 -1.5 -0.5
Overall health rating 2.3 5.0 10.5 -0.9 -2.1 -1.7 -1.4 -3.2 3.1
Chest pain or discomfort 0.5 0.8 2.9 -0.6 0.5 -0.6 1.7 -0.8 0.5
Had major operations 1.8 2.1 5.9 -0.5 2.4 1.6 -0.2 1.9 0.5
Age at last live birth 0.2 0.2 0.5 0.3 -0.4 0.7 0.6 0.2 -0.4
Family relationship satisfaction 2.3 2.8 3.4 1.2 -1.8 -1.8 -1.8 -1.6 1.6
Leg pain on walking 0.2 0.2 0.4 0.5 0.2 -0.6 0.5 0.7 -0.0
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 3.0 -0.2 -0.6 -0.1 -1.6 -0.4 1.7
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.2 -0.6 -0.8 -1.1 0.9 0.2 0.3
Illness, injury, bereavement, stress in last 2 years 1.5 1.8 5.5 0.9 1.4 1.4 0.0 2.4 -0.9
Medication: Aspirin 2.8 3.7 8.9 -1.1 -2.5 -3.0 -0.4 -1.9 1.3
Supplements: Vitamin C 1.9 2.3 6.6 2.6 -0.2 0.8 2.4 0.4 -0.8
Knee pain experienced in last month 0.6 1.0 2.4 -0.3 -0.8 -0.7 -1.5 -0.2 1.6
Hypertension (Self-reported) 0.7 2.1 7.6 -0.1 -0.1 -2.8 0.8 0.2 -2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 2.2 0.2 1.5 0.3 0.2 0.5 -0.6
Illnesses of father: Heart disease 0.3 0.4 1.4 1.0 0.3 -1.2 0.2 -0.4 -0.0
Illnesses of siblings: Diabetes 0.1 0.2 0.7 -0.2 -0.1 0.8 -0.1 -0.4 0.5
Smoking status: Previous 1.5 2.2 7.0 0.2 2.7 2.2 -0.3 0.1 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 4.2 1.1 -0.7 -0.8 1.6 2.0 -1.4
Whole body fat-free mass 0.6 3.3 14.0 0.3 1.2 -1.1 1.1 3.7 -1.2
Leg fat-free mass (right) 0.2 1.1 3.4 1.1 0.2 -1.4 0.4 1.8 -0.2
Arm fat percentage (left) 2.7 10.6 22.0 1.0 -4.0 -2.4 -2.5 -4.7 3.6
Average weekly red wine intake 0.2 0.2 0.8 -0.1 0.3 0.3 0.7 0.9 -0.2
Handedness (chirality/laterality): Left-handed 0.1 0.2 0.5 0.7 -0.5 -0.4 0.1 -0.3 0.1
Mood swings 0.6 1.1 3.2 1.8 -0.7 -0.2 0.4 -1.4 -0.8
Loneliness, isolation 1.7 2.4 4.8 1.1 -2.0 -1.0 0.1 -2.2 1.8
Long-standing illness, disability or infirmity 0.5 0.8 2.1 0.0 -1.1 -1.4 -0.4 -0.7 1.1
Ever had bowel cancer screening 1.9 2.2 7.3 -1.1 1.5 2.7 0.5 1.4 0.6
Diabetes diagnosed by doctor 0.4 0.7 2.3 -0.7 -1.5 -0.4 -0.0 -0.7 0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.5 0.7 -0.5 -0.3 -0.8 -1.2 0.8
Friendships satisfaction 3.0 3.7 5.9 -0.1 -2.4 -2.3 -1.4 -2.0 2.3
Qualifications: nursing, teaching 0.6 0.9 3.0 -1.5 -0.2 -1.7 -0.0 -0.0 0.5
Commuting to job workplace: Walk 0.5 0.5 1.7 1.3 0.5 0.6 -0.7 -0.5 0.2
Eye problems/disorders: Cataract 1.4 1.7 7.3 2.7 -1.0 0.3 1.1 -0.5 0.3
Mouth/teeth dental problems: Mouth ulcers 2.4 3.8 8.8 0.6 -3.0 -1.1 -1.5 -2.3 2.2
Medication for cholesterol 3.5 5.4 20.5 2.6 1.0 4.5 0.7 1.2 -1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 2.9 0.9 1.7 1.1 -1.6 -0.5 0.0
Back pain experienced in last month 2.0 2.9 5.4 -1.8 -0.5 -0.9 -2.3 -1.6 2.2
Mineral and other dietary supplements 3.9 5.2 13.5 -3.7 -2.0 -2.2 -0.8 -1.8 2.2
Breast cancer (self-reported) 0.9 1.1 2.8 1.7 0.4 0.8 -1.3 -1.2 0.2
Asthma (self-reported) 1.3 2.6 7.8 -2.8 1.2 -0.6 -0.9 -1.3 1.9
Osteoporosis (self-reported) 1.4 1.7 5.3 1.4 -0.6 2.3 1.4 0.9 0.5
Osteoarthritis (self-reported) 0.5 0.6 1.6 1.2 0.1 1.3 0.5 0.4 -0.1
Medication: Aspirin 2.6 3.4 8.8 -1.5 -1.9 -3.0 -0.7 -1.9 1.3
Medication: Gliclazide 2.2 2.5 8.5 -2.9 -1.1 -1.4 -0.8 -1.0 1.3
Illnesses of father: None of the above (group 1) 0.6 0.7 3.8 -0.5 0.2 2.0 0.2 -0.0 -0.5
Smoking status: Current 0.1 0.2 0.3 -0.5 -0.6 -0.5 0.4 -0.5 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.2 6.4 1.7 0.9 -0.2 0.5 1.7 -2.5
Whole body water mass 0.6 3.5 14.6 0.3 1.2 -1.2 1.2 3.8 -1.3
Leg predicted mass (right) 0.2 1.1 3.4 1.1 0.2 -1.4 0.4 1.8 -0.1
Arm fat mass (left) 1.3 5.3 8.9 0.6 -3.0 -2.6 -1.5 -2.5 2.6
Number of self-reported non-cancer illnesses 0.4 0.7 1.6 -0.3 0.6 -0.7 -1.3 -0.3 1.1
Average weekly champagne plus white wine intake 0.9 1.2 2.2 1.5 1.0 1.4 1.0 -0.5 -0.9
Miserableness 0.5 0.9 1.7 1.0 -1.2 -1.0 0.0 -1.3 0.2
Guilty feelings 1.1 1.6 2.9 -0.8 -1.7 -1.1 -1.5 -0.8 1.4
Wears glasses or contact lenses 0.7 0.8 2.6 -0.7 -0.4 1.6 0.6 0.5 0.9
Ever taken oral contraceptive pill 0.4 0.4 1.0 -0.9 0.2 -1.0 0.5 -0.5 0.1
Hearing aid user 1.2 1.4 3.5 0.1 -1.6 -0.5 0.8 -1.1 1.9
Mother’s age at death 1.0 1.3 4.0 0.7 0.4 2.0 0.7 1.6 -0.2
Financial situation satisfaction 2.5 3.2 8.7 1.8 -2.9 -1.0 -0.5 -2.0 1.3
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.4 -0.6 -0.2 0.3 0.2 -0.0 0.4
Commuting to job workplace: Public transport 0.6 0.8 2.0 0.4 1.4 1.4 -0.6 -0.3 -0.4
Eye problems/disorders: Glaucoma 1.2 1.4 3.0 1.7 0.6 0.9 1.7 0.2 -1.2
Medication: Blood pressure 1.4 2.6 11.0 -1.1 -1.1 -3.3 -0.2 -1.5 0.3
Pain type(s) experienced in last month: Hip pain 0.8 1.0 3.8 -0.3 1.1 0.6 0.4 2.0 0.2
Supplements: Fish oil (including cod liver oil) 2.8 3.7 9.1 3.0 1.7 2.0 0.7 1.3 -2.0
High cholesterol (Self-reported) 1.7 3.1 9.9 -3.1 0.4 -2.3 -1.7 0.6 0.4
Medication: Bendroflumethiazide 2.3 3.4 8.5 -2.4 -2.0 -2.9 -0.1 -1.1 1.2
Medication: Paracetamol 1.0 1.5 4.1 2.0 1.7 0.3 -0.5 0.9 -0.9
Medication: Lisinopril 2.0 2.5 4.7 -2.2 -0.8 -2.1 -1.5 -1.1 1.3
Medication: Atorvastatin 0.8 1.0 4.0 -0.8 -0.8 -2.0 0.0 -0.5 0.8
Illnesses of father: High blood pressure 1.3 1.6 3.7 0.5 -1.2 -1.9 0.7 -0.8 -1.8
Alcohol drinker status: Never 0.3 0.4 0.9 0.9 -0.2 0.9 -0.1 -0.6 -0.2
Ever smoked 1.8 3.1 6.6 0.5 2.6 2.1 0.6 0.9 -2.5
Basal metabolic rate 0.4 2.0 8.1 0.4 0.4 -1.6 0.8 2.8 -0.6
Leg fat percentage (left) 2.3 8.2 12.3 -0.6 -3.3 -2.5 -2.6 -3.5 3.5
Arm fat-free mass (left) 0.7 3.5 14.1 -0.5 1.1 -1.8 1.0 3.8 -0.8
Number of operations (self-reported) 1.0 1.5 5.5 -0.1 0.8 2.3 -0.4 0.4 1.5
Average weekly beer plus cider intake 0.2 0.3 0.6 -0.5 0.4 0.8 -0.2 -0.3 -0.8
Irritability 0.5 0.8 1.8 1.4 -0.5 -0.0 -1.1 -1.3 0.1
Risk taking 0.5 0.8 2.7 0.0 -0.6 -1.7 0.3 -1.2 0.1
Ever had prostate specific antigen (PSA) test 2.9 3.3 5.8 0.6 1.4 2.3 1.9 2.4 -1.6
Fractured/broken bones in last 5 years 0.6 0.8 1.9 0.6 0.3 1.4 1.0 -0.1 -1.1
Age started oral contraceptive pill 0.6 0.8 1.7 0.5 -0.1 1.2 -0.6 -1.0 1.3
Diastolic blood pressure, automated reading 1.0 3.1 14.1 -0.0 -0.5 -3.8 -0.4 0.3 -1.9
Ever depressed for a whole week 0.5 0.6 2.1 1.4 -0.3 -0.6 0.5 0.8 -0.5
Unable to work because of sickness or disability 0.5 0.7 1.6 -0.4 -1.3 0.0 0.8 -1.2 0.4
Commuting to job workplace: Cycle 0.6 0.7 1.8 -0.2 1.2 0.6 0.6 0.5 -1.4
Myopia 0.4 0.6 1.5 -0.7 0.0 -1.2 -0.7 -0.6 0.8
Vascular/heart problems diagnosed by doctor 0.9 2.5 11.9 0.0 0.2 3.4 -0.6 0.4 1.5
Cholesterol lowering medication 3.7 5.4 15.1 -2.6 -1.4 -3.9 -1.6 -2.0 1.6
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 0.9 -0.9 0.5 -0.5 -0.6 -0.5 1.0
Pain experienced in last month 1.6 2.7 5.6 1.6 1.0 1.6 1.9 1.0 -2.4
Supplements: Calcium 2.2 2.4 5.4 1.3 1.1 0.9 1.3 2.3 -2.0
Basal cell carcinoma (self-reported) 2.5 3.0 6.6 -1.2 -1.6 -1.0 -2.4 -1.0 2.6
Heart attack/myocardial infarction (self-reported) 1.4 1.8 7.3 -1.7 0.1 -2.7 -0.5 -0.2 0.6
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.9 0.6 0.2 1.7 0.4 1.4 0.4
Heart disease (siblings) 1.2 1.5 3.2 -1.7 -0.7 -1.3 -1.8 -0.0 0.9
Alcohol drinker status: Previous 0.4 0.4 1.1 -0.2 0.2 0.1 0.6 -0.9 1.1
Pack years of smoking 0.5 0.7 2.0 -0.2 -0.9 -0.7 0.2 -0.8 1.4
Impedance of whole body 0.5 2.5 8.6 1.4 -2.0 0.8 0.2 -2.9 0.4
Leg fat mass (left) 1.5 5.9 9.1 -0.4 -3.0 -2.8 -1.9 -2.4 3.0
Arm predicted mass (left) 0.7 3.6 14.7 -0.3 1.0 -1.8 1.1 3.8 -1.1