Hub : Genes

MTA3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.1518	0.0651	0.00310	0.010	NA	0.015	NA	0.027	0.130	NA	0.094	NA	0.038
2	GTEx	Cells EBV-transformed lymphocytes	0.3450	0.1110	0.00018	0.002	NA	0.037	NA	-0.003	0.270	NA	0.024	NA	0.410
3	GTEx	Cells Transformed fibroblasts	0.0940	0.0430	0.00530	-0.003	NA	0.003	NA	-0.002	0.720	NA	0.180	NA	0.470
4	GTEx	Skin Not Sun Exposed Suprapubic	0.1440	0.0590	0.00380	0.004	NA	0.011	NA	0.015	0.190	NA	0.079	NA	0.046
5	GTEx	Spleen	0.4000	0.1020	0.00065	-0.009	NA	0.016	NA	0.021	0.660	NA	0.130	NA	0.092
6	YFS	Blood	0.0157	0.0074	0.00093	0.004	0.008	0.000	0.007	0.003	0.018	0.0012	0.220	0.0016	0.036

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.8	1.2	3.1	0.8	0.7	-0.2	1.0	1.8	-1.4
Bipolar Disorder or Schizophrenia	0.5	1.2	2.0	0.5	-0.0	-1.4	1.2	1.3	-1.3
Depressed Affect (Nagel 2018)	0.8	1.7	6.5	2.5	-1.3	-0.1	0.2	-1.4	0.2
Depression (Nagel 2018)	0.8	1.2	2.6	1.6	-1.6	0.6	1.0	-0.8	0.4
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.3	0.3	0.1	-0.5	-1.1	-1.1	0.2
Neuroticism (Nagel 2018)	1.0	2.3	4.5	1.7	-2.0	-1.0	-0.8	-2.1	1.0
Schizophrenia (2018)	0.3	0.7	2.8	-0.0	-0.6	-1.7	0.7	0.2	-0.6
Schizophrenia vs Biploar Disorder	2.1	2.8	5.5	-1.3	-1.5	-1.8	-1.2	-2.3	1.5
Worry (Nagel 2018)	0.2	0.4	0.9	0.3	-0.6	-0.9	-0.6	-1.0	-0.1
Alzheimer’s Disease (in mother)	1.8	2.1	4.1	-0.7	-1.0	0.7	-2.0	-1.6	2.0
Alzheimer’s Disease (in father)	1.1	1.2	3.0	-1.5	0.8	0.7	0.8	1.7	0.0
Alzheimer’s Disease (including proxy)	0.6	0.9	3.7	-0.9	0.7	1.9	-0.5	0.3	0.5
Crohns Disease (2017)	0.4	0.9	1.5	-0.8	0.2	0.9	-1.2	-1.1	1.0
Irritable Bowel Disease (IBD)	0.1	0.3	1.1	-0.2	1.0	0.7	-0.1	-0.6	-0.3
Ulcerative Colitis (UC)	0.2	0.4	1.0	0.1	1.0	0.0	0.5	-0.3	-0.9
Major Depression (MDD)	3.5	4.3	9.4	-0.7	-1.0	-2.2	-2.3	-3.1	2.1
Reaction Time	2.7	5.2	9.9	-2.5	-1.7	-1.9	-1.4	-3.1	2.5
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.4	0.7	0.5	-0.5	-0.3	-1.1	-1.2
Breast Cancer	0.8	2.0	5.1	0.1	0.7	1.5	-1.3	1.5	-2.3
Ovarian Cancer	1.0	1.3	5.5	2.3	0.0	1.1	0.4	-0.6	-0.7
Prostate Cancer	1.3	1.9	3.5	-1.1	1.7	0.9	0.8	1.9	-1.5
Age at First Birth	0.6	0.9	1.9	0.3	0.1	-0.7	1.0	1.3	-1.4
Bipolar Disorder (2011)	1.9	1.8	3.4	1.8	-0.1	-1.4	1.6	1.0	-1.3
Body Mass Index (BMI) (2010)	4.4	6.0	10.3	-0.6	-2.1	-2.1	-2.5	-3.2	3.2
Coronary Artery Disease (CAD)	1.4	1.6	7.0	0.1	-1.1	-2.6	-0.6	-0.7	0.7
Crohns Disease (2012)	1.0	1.5	4.0	-2.0	-0.3	1.3	-1.4	-0.7	1.1
Mean Putamen Volume	0.2	0.2	0.4	0.1	0.6	0.5	0.5	-0.7	-0.0
Fasting Glucose	2.8	3.3	5.2	0.3	2.2	1.9	1.4	2.1	-2.3
HbA1C	1.5	1.7	2.8	1.7	0.8	1.5	1.0	-1.2	-1.4
HDL Cholesterol	0.4	0.7	0.9	0.8	0.5	0.9	0.8	0.9	-0.8
LDL Cholesterol	0.8	1.3	4.6	-1.1	0.7	-0.0	-1.2	-2.1	0.5
Lupus	0.3	0.4	1.0	0.9	1.0	0.3	-0.5	0.3	0.1
Neuroticism (2016)	1.2	1.7	4.4	2.1	-0.9	-0.9	1.7	-1.0	0.4
Primary Biliary Cirrhosis	1.0	1.4	2.9	1.1	0.2	1.2	1.7	1.4	-0.7
Rheumatoid Arthritis	0.5	0.6	1.0	1.0	-0.7	0.1	1.0	0.6	-0.9
Schizophrenia (2014)	0.4	0.9	2.3	0.5	-0.1	-1.5	1.3	0.4	-1.1
Triglycerides	1.3	2.2	4.2	-2.1	-0.1	-1.4	-1.6	-1.5	1.4
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.4	0.5	0.2	0.1	-0.6	0.3	0.5
Ulcerative Colitis	0.4	0.6	2.2	-0.2	1.5	0.5	0.9	0.3	-0.4
Blood Eosinophil Count	0.2	1.9	3.8	-0.5	1.8	1.3	1.9	0.8	-1.3
Blood Platelet Count	0.4	4.2	11.4	-1.1	-0.6	2.5	-0.7	-2.4	3.4
Blood Red Count	0.4	3.4	6.1	-2.5	0.2	-2.4	-1.4	-2.3	1.3
Blood White Count	1.0	7.7	15.9	0.7	3.6	2.1	3.3	1.1	-4.0
Heel T-Score	3.0	24.2	62.7	3.7	7.3	-3.7	1.2	-0.5	-7.9
BMI	1.5	8.6	23.7	-1.1	-2.9	-4.9	-1.7	-1.6	3.6
Height	0.4	7.9	27.4	2.0	1.8	0.9	2.9	5.2	-1.9
Waist Hip Ratio (WHR)	0.8	3.5	9.7	2.5	-1.6	-0.4	1.1	-3.1	1.1
Systolic Blood Pressure	1.3	6.6	16.8	-0.9	-0.1	-3.7	2.6	0.9	-4.1
Smoking Status	0.6	1.3	4.2	0.3	1.4	2.0	0.8	0.3	-1.0
Allergy or Eczema	0.3	0.8	3.8	0.5	1.9	0.3	0.4	0.5	-0.3
Cardiovascular Disease	1.1	3.7	18.3	-0.7	-0.0	-4.3	0.4	0.1	-1.9
Hypothyroidism (self reported)	0.6	1.3	2.6	0.8	1.4	1.6	1.0	0.9	-1.0
Respiratory disease	1.8	3.9	12.1	-3.5	1.9	-0.8	-1.6	-0.6	2.0
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.9	0.1	-1.0	-0.3	0.8	-0.1	-0.2
Lung FEV1/FVC ratio	6.8	34.4	46.8	5.0	6.8	6.7	0.5	6.8	-6.7
Lung FVC	0.4	1.9	3.9	2.0	-0.2	-0.1	-2.0	0.8	-1.6
Neuroticism	0.8	1.9	2.9	1.0	-1.7	-1.4	-1.2	-1.4	1.4
Chronotype (morning person)	0.7	1.5	3.6	0.6	1.0	1.9	1.6	1.1	-0.7
Hair Pigment	0.0	1.1	2.9	-1.7	-0.8	0.7	-1.0	1.2	0.4
Tanning	0.8	9.4	14.6	0.7	3.3	3.1	2.7	3.7	-3.8
Hand grip strength (left)	1.3	3.5	7.2	0.4	1.7	-2.3	1.6	2.7	-1.8
Number of treatments/medications taken	0.2	0.4	0.8	0.9	0.1	-0.8	0.6	-0.2	-0.8
Average weekly spirits intake	2.8	3.4	9.9	-0.1	3.1	1.1	1.1	1.5	-2.4
Sensitivity / hurt feelings	1.3	2.2	5.6	1.4	-2.4	-1.0	-0.9	-0.9	1.8
Frequency of depressed mood in last 2 weeks	0.8	1.1	4.5	0.9	-1.1	0.3	0.1	-2.1	0.3
Hearing difficulty/problems: Yes	1.6	2.4	7.3	-0.1	-1.8	-1.0	-1.4	-1.2	2.7
Relative age of first facial hair	1.0	2.0	6.5	0.5	-1.5	-2.5	-0.3	-1.8	0.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.1	1.1	-0.2	0.3	-0.4	-0.9	0.7
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.8	-0.3	-0.4	-0.9	-0.9	-1.4	1.7
Ever had hysterectomy (womb removed)	0.4	0.5	1.3	0.0	1.1	0.1	1.0	0.2	-0.6
Systolic blood pressure, automated reading	0.2	0.5	1.2	-1.1	0.0	-0.9	-0.0	-0.1	-0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.8	-0.3	-0.8	-0.5	-0.7	-1.3	0.6
Angina	0.8	1.1	4.8	-0.9	-0.1	-2.2	-0.4	-0.0	0.7
Medication for hormone replacement therapy	0.7	0.8	2.9	-0.8	-0.7	-1.7	-0.5	0.4	0.5
Vitamin and mineral supplements	2.3	3.2	6.4	-1.9	-2.0	-2.5	-1.2	-0.5	1.7
Supplements: Zinc	0.9	0.9	1.8	1.0	0.9	1.2	-0.4	0.8	-1.3
Medication: Co-codamol	0.3	0.4	0.6	0.7	0.8	-0.7	0.5	-0.7	-0.1
Medication: Metformin	0.9	1.3	2.4	-1.0	-1.5	0.9	0.0	-1.4	1.2
Diabetes (father)	1.5	1.9	6.2	1.0	-2.5	0.1	2.0	0.0	0.3
Diabetes (mother)	0.9	1.1	2.3	1.3	0.4	1.1	0.6	0.9	-1.5
Severe depression (siblings)	0.6	0.7	1.4	-0.6	-1.2	-0.3	-1.2	-0.3	1.0
Pack years adult smoking proportion	0.3	0.5	1.3	-0.3	-0.8	-0.6	0.3	-0.6	1.1
Impedance of leg (right)	0.1	0.6	2.0	-0.5	-1.4	0.2	0.4	-1.1	-0.2
Leg fat-free mass (left)	0.2	0.9	2.6	0.8	-0.3	-1.5	0.2	1.6	0.3
Trunk fat percentage	2.4	9.5	18.2	1.1	-3.9	-2.2	-2.2	-4.3	3.5
Hand grip strength (right)	1.1	3.1	6.7	0.1	1.7	-1.5	2.2	2.6	-1.5
Townsend deprivation index at recruitment	0.9	1.3	3.0	-0.8	-1.1	-1.7	-0.7	-1.2	0.9
Current tobacco smoking	0.1	0.2	0.8	-0.1	-0.3	-0.1	0.9	0.2	-0.2
Average weekly fortified wine intake	0.7	0.9	1.9	1.4	0.5	0.5	0.9	0.6	-1.3
Maternal smoking around birth	0.7	1.0	3.5	1.0	0.1	-0.2	0.6	1.1	-1.9
Fed-up feelings	1.8	3.3	9.4	1.4	-2.0	-0.7	-1.1	-3.1	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.5	1.0	-1.6	-0.8	0.8	-1.6	0.7
Relative age voice broke	1.4	2.1	3.9	1.0	-0.7	-1.9	1.8	-0.3	-2.0
Taking other prescription medications	1.6	2.5	5.5	1.2	-2.0	-0.9	0.9	-2.3	1.6
Age when periods started (menarche)	0.7	1.6	5.9	1.8	-2.4	-0.5	0.8	0.0	-0.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.8	-0.7	-0.9	0.0	-0.5	-0.9	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	8.3	1.6	0.8	-2.0	0.7	-1.7	-2.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.2	1.1	-0.8	-0.2	-0.1	0.2	0.1
Qualifications: CSEs or equivalent	0.5	0.7	1.4	1.0	0.2	0.8	0.9	1.2	-0.5
Serious illness, injury or assault to yourself	0.6	0.7	1.3	0.6	0.9	0.7	0.5	1.0	-1.1
High blood pressure	0.7	1.9	5.6	0.2	0.0	-2.4	1.0	-0.0	-2.1
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.2	1.0	1.8	0.0	0.3	0.4	-1.0
Multivitamins +/- minerals	3.4	4.3	9.6	1.4	2.5	3.1	0.7	0.7	-2.6
Stomach or abdominal pain in last month	1.9	2.4	6.7	-2.4	-0.2	-1.0	-0.6	-2.6	0.8
Supplements: Glucosamine	3.5	4.5	9.5	2.6	1.8	0.9	2.2	1.5	-3.1
Diverticular disease/diverticulitis (self-reported)	3.4	4.1	6.8	-0.0	2.6	0.1	2.3	2.4	-2.5
Medication: Atenolol	2.2	2.7	9.4	-2.4	-0.2	-3.1	-1.1	-0.4	0.4
Medication: Levothyroxine sodium	1.3	2.3	7.7	0.9	1.6	2.8	0.7	1.0	-0.9
Sitting height	1.2	8.7	23.2	-4.8	0.0	-4.4	-0.0	3.0	0.1
Chronic bronchitis/emphysema (father)	4.1	4.8	10.6	-1.6	-0.7	-1.4	-3.3	-1.9	3.1
High blood pressure (mother)	0.9	1.3	6.3	-0.1	-0.7	-2.5	-0.1	-1.0	-0.4
Body mass index (BMI)	1.2	5.0	8.1	-0.6	-2.3	-2.9	-1.9	-2.2	2.8
Impedance of leg (left)	0.1	0.4	1.2	-0.3	-0.8	0.2	0.3	-1.1	-0.6
Leg predicted mass (left)	0.2	1.0	2.9	0.8	-0.2	-1.5	0.2	1.7	0.3
Trunk fat mass	1.3	5.6	10.0	1.0	-3.2	-2.3	-1.5	-2.6	2.9
Waist circumference	0.9	3.2	7.6	1.0	-2.8	-1.9	-0.4	-1.9	1.7
Number of incorrect matches in round	1.2	2.0	4.5	1.2	2.1	2.0	0.4	1.2	-0.5
Past tobacco smoking	0.9	1.6	5.2	0.0	-2.3	-1.8	0.3	0.2	1.0
Alcohol usually taken with meals	1.1	1.8	3.2	1.6	1.2	0.3	1.2	1.4	-1.8
Nervous feelings	1.6	2.9	5.5	-1.0	-2.0	-1.6	-1.6	-2.4	1.4
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	9.4	0.0	-1.2	-1.8	-0.7	-3.1	1.5
Hearing difficulty/problems with background noise	0.7	1.2	3.6	-0.1	-0.7	-0.3	-1.4	-1.0	1.9
Hair/balding pattern: Pattern 2	0.7	0.9	2.1	-0.8	1.1	1.5	0.7	0.3	1.0
Had menopause	1.1	1.3	2.9	-0.4	0.3	1.5	-0.9	-1.4	1.7
Had other major operations	0.9	1.1	3.2	0.9	-1.8	-0.4	0.5	-1.4	0.6
Forced vital capacity (FVC)	0.4	1.6	4.1	0.7	-0.1	-1.1	-0.7	2.0	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.9	8.4	1.4	1.1	-2.4	-0.0	-2.4	-2.9
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	3.9	1.3	-2.0	-1.2	0.7	-0.2	0.3
Qualifications: None of the above	0.1	0.2	0.5	-0.5	-0.2	0.6	-0.7	-0.3	0.3
Financial difficulties in last 2 years	2.3	3.1	10.9	1.0	-3.3	-1.5	0.4	-1.9	0.7
Mouth/teeth dental problems	1.3	2.0	5.4	0.4	1.2	1.2	1.3	2.3	-1.3
Heart attack	1.4	1.8	6.8	-1.8	0.1	-2.6	-0.5	-0.3	0.6
Allergy	0.4	1.0	4.9	-0.3	-2.2	-0.5	-0.4	-0.7	0.0
Pain all over the body in last month	1.1	1.1	3.0	1.7	-0.3	-0.2	1.0	-0.5	-1.6
Diabetes (self-reported)	0.3	0.5	1.6	-0.5	-1.3	-0.3	-0.5	-0.8	0.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.3	1.1	0.9	0.2	-0.0	0.9	-0.7
Medication: Ramipril	2.1	2.7	5.3	-0.9	0.8	-2.0	2.0	1.2	-2.3
Medication: Simvastatin	1.8	2.7	8.2	-2.2	-0.7	-2.9	-1.4	-0.6	0.7
Fluid intelligence score	0.8	1.6	2.9	-1.3	0.8	-1.3	-1.6	-1.7	0.2
Illnesses of siblings	0.9	1.2	3.1	1.1	1.8	1.4	0.5	0.8	-0.5
Neuroticism score	1.7	3.5	6.6	0.2	-2.4	-1.8	-1.9	-2.6	1.5
Weight	0.4	1.8	6.2	-0.2	-1.5	-2.5	-0.6	-0.1	1.5
Impedance of arm (right)	1.3	6.1	17.2	3.1	-2.6	1.6	-0.4	-4.2	0.8
Arm fat percentage (right)	2.3	9.1	18.9	1.5	-3.6	-2.1	-2.3	-4.3	3.4
Trunk fat-free mass	1.0	5.8	23.5	-0.0	1.9	-0.8	1.8	4.8	-2.1
Hip circumference	0.3	1.3	3.4	0.2	-1.8	-1.9	-1.0	0.1	0.8
Time employed in main current job	0.3	0.3	1.1	-0.2	-0.1	-0.4	0.8	-1.1	0.0
Alcohol intake versus 10 years previously	0.7	1.0	2.9	-1.0	-1.3	-1.7	0.4	0.1	-0.5
Father’s age at death	1.5	2.0	6.0	2.2	0.9	2.4	0.7	0.1	-0.3
Worrier / anxious feelings	0.2	0.4	1.7	0.6	-0.4	0.0	0.4	1.3	-0.4
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	6.5	-0.5	-0.7	-1.3	-1.3	-2.5	1.5
Falls in the last year	1.0	1.3	3.5	0.2	-1.8	0.8	-0.4	-1.9	0.5
Hair/balding pattern: Pattern 3	0.2	0.3	0.9	0.4	0.6	-1.0	0.1	-0.5	-0.3
Number of live births	0.6	0.8	3.1	-0.9	0.0	0.6	-1.8	0.3	0.6
Forced expiratory volume in 1-second (FEV1)	1.5	5.0	12.2	2.1	1.4	0.4	-0.6	3.5	-3.3
Pulse rate	0.4	0.7	1.5	-1.1	-1.0	-0.4	-0.2	-1.2	0.4
Happiness	1.4	1.7	2.6	1.4	-1.6	-1.6	-0.7	-1.2	1.1
Noisy workplace	0.4	0.5	1.8	-1.4	0.3	0.4	0.8	-0.4	-0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.1	0.6	0.2	0.0	-0.4	1.0	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.0	-0.7	-0.2	-0.3	0.6	-1.0	0.3
Mouth/teeth dental problems: Dentures	0.6	1.0	3.9	-1.0	0.0	-0.8	-0.2	-2.0	0.7
Asthma	1.1	2.3	5.8	-2.4	1.3	-0.3	-0.9	-1.6	1.7
Medication: Ibuprofen (e.g. Nurofen)	2.7	3.5	7.5	2.7	1.5	1.7	1.0	1.9	-1.9
Medication: Cholesterol lowering	0.7	1.1	3.5	-1.4	-0.8	-1.9	-0.1	0.4	0.6
Depression (self-reported)	0.7	0.8	3.9	0.3	-0.3	0.5	-0.4	-2.0	0.5
Medication: Lansoprazole	0.1	0.1	0.3	0.0	-0.3	-0.4	0.1	-0.6	0.3
Prospective memory result	1.8	2.2	6.4	0.8	1.9	2.5	0.2	1.0	-1.1
Lung cancer (father)	3.8	4.4	10.8	-2.2	-1.0	-1.1	-3.3	-2.4	1.7
Illnesses of mother	3.1	3.8	12.6	2.5	0.4	3.5	0.9	1.0	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.6	14.3	2.0	1.1	0.6	0.8	3.6	-3.8
Pulse wave Arterial Stiffness index	2.8	3.3	8.4	-0.3	2.9	1.6	1.1	1.3	-2.4
Impedance of arm (left)	1.3	6.1	18.6	2.6	-2.8	1.5	-0.5	-4.3	1.0
Arm fat mass (right)	1.3	5.2	8.3	0.9	-2.9	-2.5	-1.5	-2.4	2.8
Trunk predicted mass	1.0	5.7	22.8	0.1	1.8	-0.8	1.8	4.8	-2.1
Standing height	0.7	7.3	24.2	0.9	1.9	0.5	2.7	4.9	-2.6
Length of working week for main job	2.1	2.3	5.2	-2.3	-0.5	-0.8	-1.6	-1.9	1.1
Exposure to tobacco smoke at home	0.2	0.2	0.8	-0.9	-0.2	-0.0	0.8	-0.1	-0.2
Breastfed as a baby	1.2	1.5	2.9	-0.8	1.6	-0.2	1.2	1.7	-1.1
Tense / ‘highly strung’	0.8	1.2	2.8	-0.9	-0.3	-1.7	-1.3	-1.3	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	5.1	2.0	-1.6	-0.7	0.0	-2.3	0.7
Hair/balding pattern: Pattern 4	0.1	0.3	1.2	1.1	-0.3	0.7	-0.4	0.2	-0.0
Birth weight of first child	0.2	0.4	1.2	0.6	-0.4	-0.5	-0.6	-0.1	1.1
Peak expiratory flow (PEF)	3.5	8.1	14.2	2.5	3.5	1.4	1.0	3.8	-3.7
Pulse wave reflection index	1.2	1.5	4.2	1.2	1.2	-0.7	0.8	0.9	-2.0
Ever highly irritable/argumentative for 2 days	0.9	1.1	4.8	0.3	-0.9	-0.4	-0.6	-2.2	0.8
Loud music exposure frequency	0.3	0.4	0.9	-0.7	0.2	1.0	-0.2	0.7	-0.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.9	1.0	-0.8	-1.1	0.5	2.0	-0.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.0	0.3	-0.5	-0.4	-1.0	-0.4	0.0
Blood clot in the leg (DVT)	0.9	1.2	3.0	0.7	0.5	1.7	0.6	1.6	0.3
Medication: Paracetamol	1.8	3.0	9.0	3.0	2.2	0.8	-1.0	1.4	-0.9
Headache pain in last month	0.5	0.9	4.8	2.2	-0.4	-0.3	-0.2	-0.4	0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.6	1.2	0.2	1.0	-0.2	-0.8	0.5
Glaucoma (self-reported)	2.2	2.6	4.8	2.2	1.3	1.4	1.9	1.2	-1.4
Gout (self-reported)	0.3	0.4	1.2	-0.4	-0.8	0.3	1.1	0.0	-0.6
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	8.1	1.0	1.2	2.8	0.8	0.0	-0.9
Medication: Amlodipine	0.8	1.2	2.1	-1.4	1.4	-0.2	1.1	-0.2	-1.3
Medication: Ventolin 100micrograms inhaler	1.5	1.9	5.0	-0.8	-1.4	-1.1	0.1	-2.2	1.7
Birth weight	1.8	4.0	11.6	0.0	-2.5	-0.2	-1.5	-1.9	3.4
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.0	-1.2	1.4	-1.1	-0.6	0.4	0.0
High blood pressure (siblings)	1.4	2.1	6.2	0.3	-2.5	-2.1	0.8	-0.8	-0.7
Forced vital capacity (FVC), Best measure	0.8	2.8	7.8	1.1	-0.2	-0.8	1.2	2.4	-2.8
Body fat percentage	2.5	10.1	18.1	0.5	-4.0	-2.5	-2.4	-4.3	3.7
Leg fat percentage (right)	2.5	9.1	14.7	-0.8	-3.8	-2.6	-2.4	-3.6	3.7
Arm fat-free mass (right)	0.8	4.2	17.6	-1.1	1.4	-1.6	0.9	4.2	-1.0
Exposure to tobacco smoke outside home	1.0	1.3	3.8	1.0	-0.3	-1.0	-0.6	-1.9	1.3
Comparative body size at age 10	0.7	1.8	3.8	-1.4	-1.3	-1.9	-0.9	-0.9	1.4
Number of full brothers	0.8	1.0	2.2	-0.8	-0.5	-0.5	-1.5	-0.9	1.4
Worry too long after embarrassment	3.2	5.4	8.6	-1.2	-1.9	-2.7	-2.9	-2.3	2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	4.4	2.1	1.6	0.1	1.7	0.2	-1.6
Wheeze or whistling in the chest in last year	1.1	1.9	3.9	-1.7	0.0	-0.9	-0.4	-1.9	2.0
Number of children fathered	1.8	2.1	4.6	-0.3	1.9	0.4	1.4	2.1	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.9	0.9	0.5	0.0	0.6	1.3	-1.4
Age at first live birth	0.4	0.7	2.0	-0.1	-0.1	0.2	1.3	1.4	-0.6
Pulse wave peak to peak time	2.5	3.0	8.1	0.4	-2.8	-1.5	-1.0	-1.0	2.3
Health satisfaction	2.2	2.9	5.0	-0.6	-2.1	-1.4	-1.0	-2.1	2.2
Shortness of breath walking on level ground	0.1	0.1	0.3	0.3	-0.3	0.5	0.5	-0.0	0.0
Qualifications: College or University degree	0.3	0.9	3.0	0.5	1.3	-0.2	0.6	-0.1	-1.7
Eye problems/disorders: None of the above	1.5	1.7	6.5	-2.6	1.0	-0.1	-1.6	0.7	-0.2
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.0	-1.4	0.7	1.0	-0.1	-0.2	0.6
Emphysema/chronic bronchitis	0.8	0.9	3.0	0.9	1.0	1.7	0.1	0.9	-0.0
Medication for pain relief, constipation, heartburn	0.8	1.4	4.2	-2.0	-1.7	0.4	0.3	-0.9	0.6
Neck or shoulder pain in last month	0.8	1.2	3.9	-0.2	-1.1	-0.4	-0.0	-2.0	1.3
Medication: Blood pressure	0.5	0.9	2.7	-0.9	-0.0	-1.1	0.7	0.5	-1.6
Angina (self-reported)	1.0	1.3	6.5	-0.9	-0.3	-2.5	-0.2	-0.2	0.7
Migraine (self-reported)	0.4	0.4	1.1	0.8	0.3	-1.0	-0.8	-0.1	0.3
Medication: Ibuprofen	2.0	2.4	4.2	1.9	1.5	0.9	1.0	1.6	-2.0
Medication: Allopurinol	0.1	0.2	0.6	-0.2	-0.5	0.0	0.8	-0.2	-0.3
Medication: Omeprazole	0.7	0.8	2.8	-0.8	-0.1	-0.0	-0.8	-0.9	1.7
Medication: Seretide 50 evohaler	0.4	0.4	1.6	-0.4	0.3	0.4	1.3	-0.5	-0.5
Mean time to correctly identify matches	1.2	2.3	4.5	-2.1	-0.4	-0.8	-1.0	-1.9	2.0
Heart disease (mother)	1.4	1.7	6.2	-1.7	-0.1	-2.5	-0.7	-0.4	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.6	0.7	-0.8	-0.6	-1.3	-1.1	1.1
Whole body fat mass	1.3	5.4	9.3	0.4	-3.0	-2.6	-1.5	-2.5	2.9
Leg fat mass (right)	1.6	6.4	10.7	-0.6	-3.3	-2.9	-1.8	-2.4	3.1
Arm predicted mass (right)	0.7	3.8	14.7	-1.0	1.3	-1.8	1.0	3.8	-1.0
Pulse rate, automated reading	0.6	2.0	9.4	-3.1	0.1	-0.5	-0.9	0.1	1.2
Alcohol intake frequency.	1.4	3.2	6.5	0.4	-2.4	-1.0	-0.5	-2.5	2.3
Comparative height size at age 10	0.9	5.2	9.5	1.9	2.6	2.3	1.7	3.1	-1.7
Number of full sisters	1.1	1.4	3.1	-0.9	-1.8	0.5	-0.6	-0.9	1.7
Suffer from ‘nerves’	0.7	1.1	2.5	0.4	-1.1	-1.6	0.2	-1.5	-0.5
Overall health rating	2.3	5.0	10.5	-0.9	-2.1	-1.7	-1.4	-3.2	3.1
Chest pain or discomfort	0.5	0.8	2.9	-0.6	0.5	-0.6	1.7	-0.8	0.5
Had major operations	1.8	2.1	5.9	-0.5	2.4	1.6	-0.2	1.9	0.5
Age at last live birth	0.2	0.2	0.5	0.3	-0.4	0.7	0.6	0.2	-0.4
Family relationship satisfaction	2.3	2.8	3.4	1.2	-1.8	-1.8	-1.8	-1.6	1.6
Leg pain on walking	0.2	0.2	0.4	0.5	0.2	-0.6	0.5	0.7	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.0	-0.2	-0.6	-0.1	-1.6	-0.4	1.7
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.2	-0.6	-0.8	-1.1	0.9	0.2	0.3
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	5.5	0.9	1.4	1.4	0.0	2.4	-0.9
Medication: Aspirin	2.8	3.7	8.9	-1.1	-2.5	-3.0	-0.4	-1.9	1.3
Supplements: Vitamin C	1.9	2.3	6.6	2.6	-0.2	0.8	2.4	0.4	-0.8
Knee pain experienced in last month	0.6	1.0	2.4	-0.3	-0.8	-0.7	-1.5	-0.2	1.6
Hypertension (Self-reported)	0.7	2.1	7.6	-0.1	-0.1	-2.8	0.8	0.2	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	2.2	0.2	1.5	0.3	0.2	0.5	-0.6
Illnesses of father: Heart disease	0.3	0.4	1.4	1.0	0.3	-1.2	0.2	-0.4	-0.0
Illnesses of siblings: Diabetes	0.1	0.2	0.7	-0.2	-0.1	0.8	-0.1	-0.4	0.5
Smoking status: Previous	1.5	2.2	7.0	0.2	2.7	2.2	-0.3	0.1	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	4.2	1.1	-0.7	-0.8	1.6	2.0	-1.4
Whole body fat-free mass	0.6	3.3	14.0	0.3	1.2	-1.1	1.1	3.7	-1.2
Leg fat-free mass (right)	0.2	1.1	3.4	1.1	0.2	-1.4	0.4	1.8	-0.2
Arm fat percentage (left)	2.7	10.6	22.0	1.0	-4.0	-2.4	-2.5	-4.7	3.6
Average weekly red wine intake	0.2	0.2	0.8	-0.1	0.3	0.3	0.7	0.9	-0.2
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.5	0.7	-0.5	-0.4	0.1	-0.3	0.1
Mood swings	0.6	1.1	3.2	1.8	-0.7	-0.2	0.4	-1.4	-0.8
Loneliness, isolation	1.7	2.4	4.8	1.1	-2.0	-1.0	0.1	-2.2	1.8
Long-standing illness, disability or infirmity	0.5	0.8	2.1	0.0	-1.1	-1.4	-0.4	-0.7	1.1
Ever had bowel cancer screening	1.9	2.2	7.3	-1.1	1.5	2.7	0.5	1.4	0.6
Diabetes diagnosed by doctor	0.4	0.7	2.3	-0.7	-1.5	-0.4	-0.0	-0.7	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.5	0.7	-0.5	-0.3	-0.8	-1.2	0.8
Friendships satisfaction	3.0	3.7	5.9	-0.1	-2.4	-2.3	-1.4	-2.0	2.3
Qualifications: nursing, teaching	0.6	0.9	3.0	-1.5	-0.2	-1.7	-0.0	-0.0	0.5
Commuting to job workplace: Walk	0.5	0.5	1.7	1.3	0.5	0.6	-0.7	-0.5	0.2
Eye problems/disorders: Cataract	1.4	1.7	7.3	2.7	-1.0	0.3	1.1	-0.5	0.3
Mouth/teeth dental problems: Mouth ulcers	2.4	3.8	8.8	0.6	-3.0	-1.1	-1.5	-2.3	2.2
Medication for cholesterol	3.5	5.4	20.5	2.6	1.0	4.5	0.7	1.2	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.9	0.9	1.7	1.1	-1.6	-0.5	0.0
Back pain experienced in last month	2.0	2.9	5.4	-1.8	-0.5	-0.9	-2.3	-1.6	2.2
Mineral and other dietary supplements	3.9	5.2	13.5	-3.7	-2.0	-2.2	-0.8	-1.8	2.2
Breast cancer (self-reported)	0.9	1.1	2.8	1.7	0.4	0.8	-1.3	-1.2	0.2
Asthma (self-reported)	1.3	2.6	7.8	-2.8	1.2	-0.6	-0.9	-1.3	1.9
Osteoporosis (self-reported)	1.4	1.7	5.3	1.4	-0.6	2.3	1.4	0.9	0.5
Osteoarthritis (self-reported)	0.5	0.6	1.6	1.2	0.1	1.3	0.5	0.4	-0.1
Medication: Aspirin	2.6	3.4	8.8	-1.5	-1.9	-3.0	-0.7	-1.9	1.3
Medication: Gliclazide	2.2	2.5	8.5	-2.9	-1.1	-1.4	-0.8	-1.0	1.3
Illnesses of father: None of the above (group 1)	0.6	0.7	3.8	-0.5	0.2	2.0	0.2	-0.0	-0.5
Smoking status: Current	0.1	0.2	0.3	-0.5	-0.6	-0.5	0.4	-0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	6.4	1.7	0.9	-0.2	0.5	1.7	-2.5
Whole body water mass	0.6	3.5	14.6	0.3	1.2	-1.2	1.2	3.8	-1.3
Leg predicted mass (right)	0.2	1.1	3.4	1.1	0.2	-1.4	0.4	1.8	-0.1
Arm fat mass (left)	1.3	5.3	8.9	0.6	-3.0	-2.6	-1.5	-2.5	2.6
Number of self-reported non-cancer illnesses	0.4	0.7	1.6	-0.3	0.6	-0.7	-1.3	-0.3	1.1
Average weekly champagne plus white wine intake	0.9	1.2	2.2	1.5	1.0	1.4	1.0	-0.5	-0.9
Miserableness	0.5	0.9	1.7	1.0	-1.2	-1.0	0.0	-1.3	0.2
Guilty feelings	1.1	1.6	2.9	-0.8	-1.7	-1.1	-1.5	-0.8	1.4
Wears glasses or contact lenses	0.7	0.8	2.6	-0.7	-0.4	1.6	0.6	0.5	0.9
Ever taken oral contraceptive pill	0.4	0.4	1.0	-0.9	0.2	-1.0	0.5	-0.5	0.1
Hearing aid user	1.2	1.4	3.5	0.1	-1.6	-0.5	0.8	-1.1	1.9
Mother’s age at death	1.0	1.3	4.0	0.7	0.4	2.0	0.7	1.6	-0.2
Financial situation satisfaction	2.5	3.2	8.7	1.8	-2.9	-1.0	-0.5	-2.0	1.3
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	-0.6	-0.2	0.3	0.2	-0.0	0.4
Commuting to job workplace: Public transport	0.6	0.8	2.0	0.4	1.4	1.4	-0.6	-0.3	-0.4
Eye problems/disorders: Glaucoma	1.2	1.4	3.0	1.7	0.6	0.9	1.7	0.2	-1.2
Medication: Blood pressure	1.4	2.6	11.0	-1.1	-1.1	-3.3	-0.2	-1.5	0.3
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.8	-0.3	1.1	0.6	0.4	2.0	0.2
Supplements: Fish oil (including cod liver oil)	2.8	3.7	9.1	3.0	1.7	2.0	0.7	1.3	-2.0
High cholesterol (Self-reported)	1.7	3.1	9.9	-3.1	0.4	-2.3	-1.7	0.6	0.4
Medication: Bendroflumethiazide	2.3	3.4	8.5	-2.4	-2.0	-2.9	-0.1	-1.1	1.2
Medication: Paracetamol	1.0	1.5	4.1	2.0	1.7	0.3	-0.5	0.9	-0.9
Medication: Lisinopril	2.0	2.5	4.7	-2.2	-0.8	-2.1	-1.5	-1.1	1.3
Medication: Atorvastatin	0.8	1.0	4.0	-0.8	-0.8	-2.0	0.0	-0.5	0.8
Illnesses of father: High blood pressure	1.3	1.6	3.7	0.5	-1.2	-1.9	0.7	-0.8	-1.8
Alcohol drinker status: Never	0.3	0.4	0.9	0.9	-0.2	0.9	-0.1	-0.6	-0.2
Ever smoked	1.8	3.1	6.6	0.5	2.6	2.1	0.6	0.9	-2.5
Basal metabolic rate	0.4	2.0	8.1	0.4	0.4	-1.6	0.8	2.8	-0.6
Leg fat percentage (left)	2.3	8.2	12.3	-0.6	-3.3	-2.5	-2.6	-3.5	3.5
Arm fat-free mass (left)	0.7	3.5	14.1	-0.5	1.1	-1.8	1.0	3.8	-0.8
Number of operations (self-reported)	1.0	1.5	5.5	-0.1	0.8	2.3	-0.4	0.4	1.5
Average weekly beer plus cider intake	0.2	0.3	0.6	-0.5	0.4	0.8	-0.2	-0.3	-0.8
Irritability	0.5	0.8	1.8	1.4	-0.5	-0.0	-1.1	-1.3	0.1
Risk taking	0.5	0.8	2.7	0.0	-0.6	-1.7	0.3	-1.2	0.1
Ever had prostate specific antigen (PSA) test	2.9	3.3	5.8	0.6	1.4	2.3	1.9	2.4	-1.6
Fractured/broken bones in last 5 years	0.6	0.8	1.9	0.6	0.3	1.4	1.0	-0.1	-1.1
Age started oral contraceptive pill	0.6	0.8	1.7	0.5	-0.1	1.2	-0.6	-1.0	1.3
Diastolic blood pressure, automated reading	1.0	3.1	14.1	-0.0	-0.5	-3.8	-0.4	0.3	-1.9
Ever depressed for a whole week	0.5	0.6	2.1	1.4	-0.3	-0.6	0.5	0.8	-0.5
Unable to work because of sickness or disability	0.5	0.7	1.6	-0.4	-1.3	0.0	0.8	-1.2	0.4
Commuting to job workplace: Cycle	0.6	0.7	1.8	-0.2	1.2	0.6	0.6	0.5	-1.4
Myopia	0.4	0.6	1.5	-0.7	0.0	-1.2	-0.7	-0.6	0.8
Vascular/heart problems diagnosed by doctor	0.9	2.5	11.9	0.0	0.2	3.4	-0.6	0.4	1.5
Cholesterol lowering medication	3.7	5.4	15.1	-2.6	-1.4	-3.9	-1.6	-2.0	1.6
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	-0.9	0.5	-0.5	-0.6	-0.5	1.0
Pain experienced in last month	1.6	2.7	5.6	1.6	1.0	1.6	1.9	1.0	-2.4
Supplements: Calcium	2.2	2.4	5.4	1.3	1.1	0.9	1.3	2.3	-2.0
Basal cell carcinoma (self-reported)	2.5	3.0	6.6	-1.2	-1.6	-1.0	-2.4	-1.0	2.6
Heart attack/myocardial infarction (self-reported)	1.4	1.8	7.3	-1.7	0.1	-2.7	-0.5	-0.2	0.6
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.9	0.6	0.2	1.7	0.4	1.4	0.4
Heart disease (siblings)	1.2	1.5	3.2	-1.7	-0.7	-1.3	-1.8	-0.0	0.9
Alcohol drinker status: Previous	0.4	0.4	1.1	-0.2	0.2	0.1	0.6	-0.9	1.1
Pack years of smoking	0.5	0.7	2.0	-0.2	-0.9	-0.7	0.2	-0.8	1.4
Impedance of whole body	0.5	2.5	8.6	1.4	-2.0	0.8	0.2	-2.9	0.4
Leg fat mass (left)	1.5	5.9	9.1	-0.4	-3.0	-2.8	-1.9	-2.4	3.0
Arm predicted mass (left)	0.7	3.6	14.7	-0.3	1.0	-1.8	1.1	3.8	-1.1