Best TWAS P=2.06e-18 · Best GWAS P=9.31e-20 conditioned to 1.96e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | KIAA1715 | 0.35 | 0.09 | bslmm | 483 | 0.19 | 2.4e-22 | 3.0 | -5.6 | 2.6e-08 | -0.01 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | KIAA1715 | 0.20 | 0.07 | enet | 28 | 0.02 | 2.1e-02 | -5.4 | -7.4 | 1.4e-13 | 0.31 | 0.18 | 0.09 | FALSE |
| 3 | GTEx | Artery Aorta | KIAA1715 | 0.13 | 0.16 | lasso | 5 | 0.14 | 3.0e-08 | -6.2 | -6.9 | 4.6e-12 | 0.48 | 0.91 | 0.08 | FALSE |
| 4 | GTEx | Artery Tibial | KIAA1715 | 0.18 | 0.11 | lasso | 7 | 0.14 | 3.7e-11 | -5.4 | -7.0 | 3.1e-12 | 0.39 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Colon Transverse | KIAA1715 | 0.20 | 0.05 | lasso | 7 | 0.04 | 4.0e-03 | -6.2 | -7.3 | 2.4e-13 | 0.43 | 0.28 | 0.14 | FALSE |
| 6 | GTEx | Esophagus Mucosa | KIAA1715 | 0.25 | 0.23 | lasso | 5 | 0.25 | 1.5e-16 | -6.2 | -6.8 | 1.5e-11 | 0.41 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Esophagus Muscularis | KIAA1715 | 0.18 | 0.08 | lasso | 4 | 0.11 | 2.6e-07 | -6.2 | -6.8 | 1.1e-11 | 0.44 | 0.88 | 0.08 | FALSE |
| 8 | GTEx | Lung | KIAA1715 | 0.24 | 0.10 | lasso | 9 | 0.07 | 7.7e-06 | -6.2 | -6.5 | 1.0e-10 | 0.41 | 0.61 | 0.38 | FALSE |
| 9 | GTEx | Nerve Tibial | KIAA1715 | 0.16 | 0.17 | lasso | 2 | 0.16 | 8.5e-12 | -5.3 | -5.3 | 1.0e-07 | 0.25 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Spleen | KIAA1715 | 0.53 | 0.05 | lasso | 14 | 0.24 | 5.5e-07 | -6.2 | -8.8 | 2.1e-18 | 0.42 | 0.16 | 0.68 | TRUE |
| 11 | GTEx | Thyroid | KIAA1715 | 0.17 | 0.09 | lasso | 6 | 0.12 | 2.5e-09 | -5.4 | -6.3 | 2.2e-10 | 0.37 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Whole Blood | KIAA1715 | 0.20 | 0.12 | enet | 20 | 0.12 | 8.8e-11 | -6.8 | -6.6 | 3.5e-11 | 0.33 | 1.00 | 0.00 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | KIAA1715 | 0.13 | 0.07 | lasso | 5 | 0.09 | 1.3e-11 | 3.0 | -6.3 | 2.3e-10 | 0.12 | 1.00 | 0.00 | FALSE |
| 14 | The Cancer Genome Atlas | Colon Adenocarcinoma | HOXD3 | 0.13 | 0.07 | lasso | 4 | 0.05 | 8.4e-04 | 5.9 | 5.7 | 1.3e-08 | -0.28 | 0.03 | 0.54 | FALSE |
| 15 | The Cancer Genome Atlas | Colon Adenocarcinoma | HOXD9 | 0.06 | 0.04 | blup | 53 | 0.02 | 2.0e-02 | 4.4 | 6.3 | 3.1e-10 | -0.57 | 0.10 | 0.17 | FALSE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HOXD11 | 0.03 | 0.02 | enet | 7 | 0.03 | 5.8e-04 | -8.1 | 5.7 | 1.3e-08 | -0.71 | 0.02 | 0.91 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | KIAA1715 | 0.03 | 0.02 | blup | 78 | 0.02 | 4.6e-03 | 4.5 | -6.0 | 1.5e-09 | 0.26 | 0.06 | 0.12 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | HOXD10 | 0.06 | 0.03 | enet | 6 | 0.03 | 5.6e-03 | 3.0 | 6.3 | 3.0e-10 | -0.67 | 0.01 | 0.69 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | KIAA1715 | 0.03 | 0.03 | enet | 5 | 0.02 | 2.1e-03 | -5.3 | -6.0 | 1.8e-09 | 0.27 | 0.10 | 0.10 | FALSE |
| 20 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | HOXD9 | 0.05 | 0.02 | blup | 54 | 0.03 | 6.1e-03 | 4.1 | 5.3 | 1.4e-07 | -0.43 | 0.04 | 0.06 | FALSE |
| 21 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | KIAA1715 | 0.06 | 0.00 | blup | 78 | 0.02 | 2.1e-02 | 4.5 | -5.4 | 6.4e-08 | 0.34 | 0.05 | 0.08 | FALSE |
| 22 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | KIAA1715 | 0.67 | 0.08 | blup | 73 | 0.19 | 1.0e-05 | 1.6 | -6.8 | 1.1e-11 | 0.19 | 0.01 | 0.30 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA1715 | 0.24 | 0.13 | blup | 78 | 0.15 | 1.5e-14 | -3.6 | -5.4 | 7.6e-08 | 0.32 | 0.98 | 0.02 | FALSE |