TWAS hub - HOXD11

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Colon Adenocarcinoma	0.0650	0.0330	0.0023	0.046	0.043	0.026	NA	0.056	0.0011	0.0016	0.01200	NA	0.00035
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0308	0.0167	0.0015	0.017	0.021	0.026	NA	0.020	0.0049	0.0018	0.00058	NA	0.00230

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Ovarian Cancer	11.5	15.2	27.3	-1.8	-5.2
Impedance of arm (right)	9.3	43.4	66.3	4.5	8.1
Impedance of arm (left)	9.2	42.7	69.4	4.0	8.3
Arm fat-free mass (right)	6.1	31.4	49.6	-3.6	-7.0
Arm predicted mass (right)	6.0	30.7	47.6	-3.7	-6.9
Arm fat-free mass (left)	6.0	30.6	49.4	-3.4	-7.0
Seen doctor (GP) for nerves, anxiety, tension or depression	5.9	9.1	10.1	-2.8	-3.2
Arm predicted mass (left)	5.9	29.8	48.7	-3.3	-7.0
Risk taking	5.6	8.1	8.9	-2.7	-3.0
Pain type(s) experienced in last month: Hip pain	5.3	6.7	9.2	-3.0	-2.1
Trunk predicted mass	5.1	29.0	46.4	-3.4	-6.8
Impedance of whole body	5.0	25.5	36.5	3.8	6.0
Trunk fat-free mass	4.9	28.1	45.2	-3.3	-6.7
Ever highly irritable/argumentative for 2 days	4.5	5.4	7.4	-2.7	-1.8
Whole body water mass	4.4	24.9	38.6	-3.3	-6.2
Whole body fat-free mass	4.3	24.7	37.6	-3.4	-6.1
Blood Red Count	4.2	41.1	75.5	-2.6	-8.7
Heart disease (mother)	4.2	5.2	7.4	-2.7	-1.7
Medication: Atenolol	3.9	4.9	5.7	-2.0	-2.4
Frequency of tenseness / restlessness in last 2 weeks	3.9	6.1	6.3	-2.4	-2.5
Basal metabolic rate	3.9	21.8	32.9	-3.2	-5.7
Irritability	3.9	6.6	9.8	-3.1	-1.8
Frequency of depressed mood in last 2 weeks	3.8	5.3	7.6	-2.7	-1.8
Medication: Ramipril	3.7	4.7	5.6	-1.9	-2.4
Serious illness, injury or assault of a close relative in last 2 years	3.7	4.3	6.4	-2.5	-1.5
Body Mass Index (BMI) (2010)	3.6	5.0	7.8	-2.8	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	3.6	4.8	5.2	-2.3	-2.1
Alcohol drinker status: Previous	3.3	3.8	4.8	-1.7	-2.2
Triglycerides	3.2	5.3	6.5	-2.0	-2.5
Loneliness, isolation	3.2	4.4	5.6	-2.4	-1.8
Illnesses of father: None of the above (group 1)	3.1	3.8	5.8	1.4	2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	3.0	3.9	5.1	-1.6	-2.3
Number of treatments/medications taken	2.9	5.3	6.4	-2.0	-2.5
Past tobacco smoking	2.9	5.3	7.1	1.9	2.7
Tense / ‘highly strung’	2.9	4.8	5.0	-2.2	-2.1
Depression (Nagel 2018)	2.8	4.2	4.8	-1.9	-2.2
Weight	2.8	13.5	18.5	-2.9	-4.3
Smoking status: Previous	2.8	4.2	6.3	-1.4	-2.5
Shortness of breath walking on level ground	2.7	3.2	6.2	-2.5	0.5
Leg predicted mass (right)	2.7	14.1	20.3	-2.8	-4.5
Tinnitus: Yes, now most or all of the time	2.7	3.1	4.5	-2.1	-1.3
Eye problems/disorders: Glaucoma	2.7	3.2	3.8	2.0	1.6
Ever depressed for a whole week	2.7	3.3	6.5	-2.5	0.3
Irritable Bowel Disease (IBD)	2.6	6.1	10.2	3.2	1.4
Ulcerative Colitis (UC)	2.6	4.8	7.1	2.7	1.6
Angina (self-reported)	2.6	3.4	5.6	-2.4	-1.1
Leg fat-free mass (right)	2.6	13.8	19.8	-2.8	-4.5
Heel T-Score	2.5	20.0	32.3	2.8	5.7
Leg fat-free mass (left)	2.5	13.2	17.6	-3.0	-4.2
Leg predicted mass (left)	2.5	13.2	17.7	-2.9	-4.2
Ever unenthusiastic/disinterested for a whole week	2.5	3.0	5.3	-2.3	-0.9
Age started oral contraceptive pill	2.5	3.2	6.4	0.2	2.5
Illnesses of mother	2.4	3.0	3.4	1.8	1.6
Medication for cholesterol	2.3	3.5	4.3	1.7	2.1
Angina	2.2	2.9	4.9	-2.2	-0.9
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	3.6	-1.4	-1.9
Medication: Gliclazide	2.2	2.4	4.1	-0.9	-2.0
Miserableness	2.2	3.8	3.9	-2.0	-1.9
Ever smoked	2.2	3.8	4.5	-2.1	-1.8
Lung FEV1/FVC ratio	2.1	10.9	21.2	-0.8	-4.6
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	3.8	-1.3	-1.9
Stomach or abdominal pain in last month	2.1	2.6	3.1	-1.8	-1.5
Alcohol intake versus 10 years previously	2.1	3.1	5.2	-2.3	-1.1
Impedance of leg (right)	2.0	9.6	11.7	2.8	3.4
Maternal smoking around birth	2.0	2.9	3.8	-2.0	-1.4
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	5.2	-2.3	-1.1
Diabetes (father)	1.9	2.4	4.7	-0.3	-2.2
Mouth/teeth dental problems	1.9	3.0	5.4	2.3	0.7
Medication: Ventolin 100micrograms inhaler	1.9	2.4	4.8	0.3	2.2
Medication: Ibuprofen	1.9	2.2	2.8	-1.3	-1.7
Diabetes diagnosed by doctor	1.9	3.2	5.6	-0.9	-2.4
Deep venous thrombosis (DVT) (self-reported)	1.9	2.5	4.5	-2.1	-0.6
Ulcerative Colitis	1.8	2.6	2.9	1.5	1.7
Sitting height	1.8	12.8	20.6	-2.2	-4.5
Impedance of leg (left)	1.8	8.9	9.0	3.0	3.0
Waist circumference	1.8	6.6	8.7	-3.0	-2.1
Commuting to job workplace: Car/motor vehicle	1.8	2.0	3.1	-1.0	-1.8
Mood swings	1.8	3.3	5.2	-2.3	-1.2
Body mass index (BMI)	1.7	7.2	7.5	-2.6	-2.7
Financial difficulties in last 2 years	1.7	2.2	3.7	-0.9	-1.9
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	3.9	2.0	0.8
Medication: Simvastatin	1.7	2.4	3.1	-1.8	-1.3
Blood clot in the leg (DVT)	1.7	2.1	3.8	-1.9	-0.7
Glaucoma (self-reported)	1.7	2.0	2.1	1.5	1.4
Mother’s age at death	1.7	2.1	3.8	0.6	2.0
LDL Cholesterol	1.6	2.5	5.0	-2.2	-0.0
Neuroticism score	1.6	3.3	3.9	-2.0	-1.6
Health satisfaction	1.6	2.1	2.6	-1.6	-1.2
Eye problems/disorders: None of the above	1.6	1.8	2.6	-1.0	-1.6
Alzheimer’s Disease (in mother)	1.5	1.7	3.0	-0.7	-1.7
Crohns Disease (2017)	1.5	3.2	6.4	2.5	-0.0
Average weekly spirits intake	1.5	1.9	2.3	-1.5	-1.2
Medication: Metformin	1.5	2.2	2.3	-1.4	-1.5
Leg fat mass (right)	1.5	6.0	7.6	-2.1	-2.8
Illnesses of father: Heart disease	1.5	2.1	3.8	-1.9	-0.6
Medication: Atorvastatin	1.5	1.9	2.2	-1.2	-1.5
Fractured/broken bones in last 5 years	1.5	2.0	2.1	1.4	1.4
Leg fat mass (left)	1.5	6.0	8.3	-1.9	-2.9
BMI	1.4	7.9	8.0	-2.8	-2.8
Qualifications: None of the above	1.4	3.0	6.1	-2.5	0.2
Fluid intelligence score	1.4	3.0	6.0	2.5	0.1
Comparative height size at age 10	1.4	7.6	7.8	-2.7	-2.8
Overall health rating	1.4	3.1	5.2	-2.3	-1.0
Family relationship satisfaction	1.4	1.7	2.6	-1.6	-0.9
Medication: Aspirin	1.4	1.8	3.2	-1.8	-0.7
Commuting to job workplace: Public transport	1.4	1.6	2.2	1.5	1.0
Neuroticism (Nagel 2018)	1.3	3.1	3.9	-2.0	-1.5
Type 2 Diabetes (T2D) (2012)	1.3	1.5	2.3	-0.9	-1.5
Length of working week for main job	1.3	1.4	2.0	-1.0	-1.4
Loud music exposure frequency	1.3	1.5	1.6	-1.2	-1.2
Wheeze or whistling in the chest in last year	1.3	2.2	3.1	-1.8	1.2
Cholesterol lowering medication	1.3	2.0	2.2	-1.5	-1.3
Schizophrenia vs Biploar Disorder	1.2	1.6	3.1	1.8	-0.2
Primary Biliary Cirrhosis	1.2	1.6	3.1	-0.5	-1.8
Supplements: Zinc	1.2	1.3	1.7	1.0	1.3
High blood pressure (mother)	1.2	1.6	2.5	-1.6	-0.9
Number of incorrect matches in round	1.2	2.0	2.4	1.3	1.6
Hip circumference	1.2	5.1	7.7	-1.6	-2.8
Illnesses of siblings: Diabetes	1.2	1.5	2.9	1.7	0.3
Osteoarthritis (self-reported)	1.2	1.5	2.9	-0.3	1.7
Commuting to job workplace: Cycle	1.2	1.5	1.6	1.3	1.1
Depressed Affect (Nagel 2018)	1.1	2.3	2.8	-1.7	-1.3
Fed-up feelings	1.1	2.0	2.3	-1.5	-1.3
Hair/balding pattern: Pattern 4	1.1	2.7	4.4	1.0	2.1
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	2.7	-1.6	-0.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	2.8	1.0	1.7
Number of full brothers	1.1	1.3	2.6	0.2	-1.6
Worry too long after embarrassment	1.1	1.9	3.3	-0.7	-1.8
Medication for pain relief, constipation, heartburn	1.1	1.9	3.8	1.9	0.3
Long-standing illness, disability or infirmity	1.1	1.7	2.6	-1.6	-0.8
Friendships satisfaction	1.1	1.4	1.6	-1.3	-1.1
Back pain experienced in last month	1.1	1.6	3.1	-1.8	-0.2
Crohns Disease (2012)	1.0	1.6	2.6	1.6	-0.8
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.1	-0.0	-1.5
Medication: Co-codamol	1.0	1.1	2.2	-1.5	0.1
Diabetes (mother)	1.0	1.3	2.7	1.6	0.1
Medication: Lansoprazole	1.0	1.2	1.4	-1.2	-1.0
Medication: Blood pressure	1.0	1.7	2.6	-1.6	-0.9
Average weekly red wine intake	1.0	1.5	1.9	1.4	1.0
Number of self-reported non-cancer illnesses	1.0	1.8	2.4	-1.5	-1.1
Myopia	1.0	1.5	3.0	-1.7	0.2
Bipolar Disorder (2018)	0.9	1.5	2.2	-1.5	-0.9
Height	0.9	16.9	21.0	-3.6	-4.6
Relative age voice broke	0.9	1.4	2.7	1.6	0.4
Taking other prescription medications	0.9	1.4	1.7	-1.3	-1.0
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.0	-0.2	1.4
Pulse wave peak to peak time	0.9	1.1	1.5	0.8	-1.2
Whole body fat mass	0.9	3.7	4.0	-1.9	-2.0
Medication: Aspirin	0.9	1.2	2.1	-1.5	-0.5
Eye problems/disorders: Cataract	0.9	1.1	2.0	0.4	1.4
Arm fat mass (left)	0.9	3.5	3.9	-2.0	-1.8
Medication: Blood pressure	0.9	1.7	1.8	-1.3	-1.3
Leg fat percentage (left)	0.9	3.1	5.1	-1.1	-2.2
Average weekly beer plus cider intake	0.9	1.3	2.5	-1.6	-0.3
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.7	-1.3	-0.5
Lupus	0.8	1.1	1.2	1.0	1.1
Neuroticism	0.8	1.9	2.2	-1.5	-1.2
High blood pressure	0.8	2.1	2.2	-1.4	-1.5
Asthma	0.8	1.7	2.8	-0.7	1.7
Arm fat mass (right)	0.8	3.3	3.5	-1.9	-1.8
Peak expiratory flow (PEF)	0.8	1.9	3.4	-0.6	-1.9
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.2	1.5	0.5
Had major operations	0.8	0.9	1.3	-0.7	-1.1
Hypertension (Self-reported)	0.8	2.4	3.1	-1.7	-1.3
Ever had bowel cancer screening	0.8	0.9	0.9	-1.0	-0.9
Pain experienced in last month	0.8	1.4	2.7	1.6	0.3
Fasting Glucose	0.7	0.9	1.4	-0.6	-1.2
Respiratory disease	0.7	1.5	2.6	-0.7	1.6
Pack years adult smoking proportion	0.7	1.0	1.8	-1.4	0.5
Chronic bronchitis/emphysema (father)	0.7	0.8	1.5	-0.3	-1.2
Nervous feelings	0.7	1.3	1.5	-1.1	-1.2
Pain all over the body in last month	0.7	0.8	0.8	0.9	-0.9
Diabetes (self-reported)	0.7	1.0	2.0	-0.2	-1.4
Falls in the last year	0.7	1.0	1.9	-1.4	-0.2
Leg fat percentage (right)	0.7	2.6	3.7	-1.2	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.4	-0.5	-1.2
Medication: Allopurinol	0.7	0.9	1.8	-1.3	0.3
Medication: Seretide 50 evohaler	0.7	0.8	1.5	-0.2	1.2
Pulse rate, automated reading	0.7	2.2	3.0	1.2	1.7
Breast cancer (self-reported)	0.7	0.9	1.0	1.0	0.8
Asthma (self-reported)	0.7	1.3	2.1	-0.7	1.4
Number of operations (self-reported)	0.7	1.1	1.5	-1.2	-0.8
Supplements: Calcium	0.7	0.8	0.9	0.8	-1.0
Pack years of smoking	0.7	1.0	1.4	-1.2	0.7
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.2	1.5	-0.8
HDL Cholesterol	0.6	1.0	1.1	1.1	1.0
Neuroticism (2016)	0.6	0.9	1.7	-0.2	-1.3
Blood Eosinophil Count	0.6	4.4	7.1	-2.7	-1.3
Average weekly fortified wine intake	0.6	0.7	0.7	-0.9	-0.8
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.1	-1.0	-0.6
Had other major operations	0.6	0.7	1.2	-1.1	0.4
Pulse rate	0.6	1.0	1.5	0.7	1.2
Mouth/teeth dental problems: Dentures	0.6	1.0	1.4	-1.2	-0.8
Depression (self-reported)	0.6	0.7	1.2	-0.6	-1.1
Pulse wave Arterial Stiffness index	0.6	0.7	0.9	-0.7	0.9
Standing height	0.6	6.3	12.0	-0.8	-3.5
Breastfed as a baby	0.6	0.7	1.0	0.7	-1.0
Pulse wave reflection index	0.6	0.7	1.4	-1.2	0.1
Chest pain or discomfort	0.6	0.8	1.7	-1.3	0.1
Leg pain on walking	0.6	0.7	1.4	-1.2	0.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.0	0.6	1.0
Knee pain experienced in last month	0.6	0.9	1.3	-0.7	1.1
Worry (Nagel 2018)	0.5	1.1	1.3	-0.9	-1.1
Alzheimer’s Disease (including proxy)	0.5	0.7	1.2	-0.5	-1.1
Prostate Cancer	0.5	0.8	1.2	0.5	1.1
Smoking Status	0.5	1.2	1.4	-1.0	-1.2
Lung FVC	0.5	2.7	3.7	1.3	1.9
Chronotype (morning person)	0.5	1.2	2.3	0.2	1.5
Medication for hormone replacement therapy	0.5	0.6	1.0	-1.0	-0.5
Age when periods started (menarche)	0.5	1.3	2.2	-0.7	1.5
Supplements: Glucosamine	0.5	0.6	1.2	-0.3	1.1
Trunk fat mass	0.5	2.1	2.1	-1.5	-1.4
Had menopause	0.5	0.6	1.1	0.2	1.1
Illnesses of siblings	0.5	0.7	0.9	-1.0	-0.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.1	-0.3	-1.8
Happiness	0.5	0.6	1.1	-1.0	0.3
Noisy workplace	0.5	0.6	1.2	-0.1	1.1
Medication: Cholesterol lowering	0.5	0.8	1.5	-0.2	-1.2
Headache pain in last month	0.5	0.8	1.6	-0.1	-1.3
High blood pressure (siblings)	0.5	0.8	0.9	-0.9	-0.8
Neck or shoulder pain in last month	0.5	0.8	1.5	-1.2	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.0	-0.4	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.3	-1.1	0.0
Guilty feelings	0.5	0.7	1.1	-1.1	-0.5
Vascular/heart problems diagnosed by doctor	0.5	1.3	1.3	1.1	1.1
Schizophrenia (2018)	0.4	0.8	1.4	1.2	0.3
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.0	-0.7	-1.0
Hearing difficulty/problems: Yes	0.4	0.6	1.0	-1.0	-0.4
Townsend deprivation index at recruitment	0.4	0.5	0.9	-1.0	-0.4
Worrier / anxious feelings	0.4	0.8	0.9	-0.9	-0.9
Hair/balding pattern: Pattern 3	0.4	0.6	0.6	0.8	-0.7
Qualifications: College or University degree	0.4	1.2	2.3	1.5	-0.3
Emphysema/chronic bronchitis	0.4	0.4	0.6	-0.5	0.8
Number of full sisters	0.4	0.4	0.5	-0.7	0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.7	-0.8	0.7
Alzheimer’s Disease (in father)	0.3	0.4	0.7	-0.1	0.8
Waist Hip Ratio (WHR)	0.3	1.5	1.9	-1.4	1.0
Systolic Blood Pressure	0.3	1.5	1.6	1.1	-1.3
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	-0.1	-0.8
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.7	-0.0	0.8
Heart attack	0.3	0.4	0.6	0.3	0.8
Father’s age at death	0.3	0.4	0.7	0.4	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.5	-0.4	-1.2
Medication: Amlodipine	0.3	0.4	0.8	-0.9	0.3
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.5	0.7	-0.4
Exposure to tobacco smoke outside home	0.3	0.4	0.8	-0.9	-0.3
Age at first live birth	0.3	0.5	1.0	1.0	-0.2
Medication: Omeprazole	0.3	0.4	0.7	0.8	0.3
Mean time to correctly identify matches	0.3	0.7	0.9	1.0	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.7	0.9	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.5	0.4	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	-0.8	0.2
Osteoporosis (self-reported)	0.3	0.4	0.4	0.7	-0.5
High cholesterol (Self-reported)	0.3	0.5	0.8	-0.4	-0.9
Reaction Time	0.2	0.5	0.8	0.9	0.3
HbA1C	0.2	0.2	0.3	-0.6	-0.3
Rheumatoid Arthritis	0.2	0.3	0.4	-0.7	-0.3
Schizophrenia (2014)	0.2	0.5	1.1	1.0	0.1
Cardiovascular Disease	0.2	0.8	1.6	-0.2	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.9	-0.3	0.9
Qualifications: CSEs or equivalent	0.2	0.2	0.3	-0.5	0.3
Serious illness, injury or assault to yourself	0.2	0.3	0.3	0.5	-0.6
Alcohol usually taken with meals	0.2	0.4	0.7	0.9	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.9	-0.2	1.0
Allergy	0.2	0.4	0.8	0.9	0.1
Time employed in main current job	0.2	0.3	0.3	0.5	0.5
Number of live births	0.2	0.3	0.5	0.3	0.7
Prospective memory result	0.2	0.2	0.3	-0.6	0.4
Exposure to tobacco smoke at home	0.2	0.2	0.3	-0.5	0.4
Birth weight	0.2	0.5	1.0	-1.0	0.3
Comparative body size at age 10	0.2	0.5	1.0	-1.0	-0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	-0.7	0.3
Alcohol intake frequency.	0.2	0.4	0.5	-0.5	-0.7
Supplements: Vitamin C	0.2	0.3	0.4	0.6	0.4
Arm fat percentage (left)	0.2	0.8	0.9	-1.0	0.8
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.3	0.5	0.6
Qualifications: nursing, teaching	0.2	0.4	0.7	-0.8	-0.2
Commuting to job workplace: Walk	0.2	0.2	0.3	-0.3	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.4	-0.6	-0.6
Average weekly champagne plus white wine intake	0.2	0.2	0.4	0.1	-0.7
Wears glasses or contact lenses	0.2	0.2	0.3	0.5	0.5
Medication: Lisinopril	0.2	0.3	0.4	-0.7	-0.4
Alcohol drinker status: Never	0.2	0.3	0.5	0.3	-0.7
Diastolic blood pressure, automated reading	0.2	0.5	0.9	-0.4	-0.9
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	-0.0	-0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.4	0.3	0.6
Heart disease (siblings)	0.2	0.3	0.5	-0.1	0.7
Intelligence (Savage-Jansen 2018)	0.1	0.5	0.9	0.9	-0.1
Breast Cancer	0.1	0.2	0.4	0.6	0.1
Mean Putamen Volume	0.1	0.1	0.3	0.5	-0.0
Blood Platelet Count	0.1	1.7	2.6	0.9	1.6
Hypothyroidism (self reported)	0.1	0.2	0.3	0.1	-0.6
Hair Pigment	0.1	2.8	4.1	2.0	1.2
Hand grip strength (left)	0.1	0.3	0.5	0.3	-0.7
Systolic blood pressure, automated reading	0.1	0.3	0.5	-0.4	-0.7
Vitamin and mineral supplements	0.1	0.2	0.3	-0.5	-0.2
Severe depression (siblings)	0.1	0.1	0.1	0.2	-0.3
Trunk fat percentage	0.1	0.3	0.4	-0.5	0.6
Current tobacco smoking	0.1	0.2	0.3	-0.2	0.5
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.2	0.1	-0.5
Medication: Levothyroxine sodium	0.1	0.2	0.2	-0.4	-0.4
Hair/balding pattern: Pattern 2	0.1	0.2	0.3	0.6	0.2
Arm fat percentage (right)	0.1	0.4	0.6	-0.7	0.6
Lung cancer (father)	0.1	0.1	0.2	-0.2	0.5
Birth weight of first child	0.1	0.3	0.5	0.1	0.7
Medication: Paracetamol	0.1	0.2	0.3	0.0	0.6
Gout (self-reported)	0.1	0.1	0.1	-0.4	-0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	0.1	-0.5
Body fat percentage	0.1	0.5	0.9	-0.9	-0.3
Number of children fathered	0.1	0.1	0.2	0.4	-0.2
Migraine (self-reported)	0.1	0.1	0.1	0.4	-0.3
Suffer from ‘nerves’	0.1	0.1	0.1	0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.4	-0.6	-0.4
Mineral and other dietary supplements	0.1	0.1	0.2	-0.3	-0.4
Ever taken oral contraceptive pill	0.1	0.1	0.1	-0.1	0.4
Hearing aid user	0.1	0.1	0.3	0.5	0.0
Financial situation satisfaction	0.1	0.2	0.3	0.5	0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	0.4	0.1
Illnesses of father: High blood pressure	0.1	0.1	0.1	-0.4	0.1
Unable to work because of sickness or disability	0.1	0.1	0.1	-0.2	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.2	0.5	-0.3
Bipolar Disorder or Schizophrenia	0.0	0.0	0.1	0.0	-0.3
Major Depression (MDD)	0.0	0.0	0.1	0.3	-0.0
Age at First Birth	0.0	0.0	0.0	0.2	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.2	0.3	0.2	-0.5
Allergy or Eczema	0.0	0.0	0.0	-0.2	-0.2
Tanning	0.0	0.5	0.9	0.3	1.0
Sensitivity / hurt feelings	0.0	0.1	0.1	-0.4	0.2
Relative age of first facial hair	0.0	0.1	0.1	0.2	0.3
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	-0.1	-0.2
Hand grip strength (right)	0.0	0.1	0.2	0.0	0.5
Multivitamins +/- minerals	0.0	0.0	0.0	0.2	0.1
Hearing difficulty/problems with background noise	0.0	0.1	0.1	0.2	0.3
Forced vital capacity (FVC)	0.0	0.0	0.1	0.3	0.0
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.1	0.3	-0.3
Forced vital capacity (FVC), Best measure	0.0	0.0	0.0	0.0	0.1
Age at last live birth	0.0	0.0	0.0	-0.1	-0.1
Smoking status: Current	0.0	0.0	0.1	-0.2	0.3
Medication: Bendroflumethiazide	0.0	0.0	0.1	-0.1	-0.3
Medication: Paracetamol	0.0	0.0	0.1	-0.3	-0.0

Hub : Genes

HOXD11

Models

Trait associations