TWAS hub - HOXD9

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.036	0.020	0.0086	0.003	0.013	-0.002	NA	0.004	0.1600	0.0260	0.570	NA	0.150
2	TCGA	Colon Adenocarcinoma	0.062	0.030	0.0017	0.040	0.021	0.000	NA	0.016	0.0024	0.0200	0.310	NA	0.037
3	TCGA	Ovarian Serous Cystadenocarcinoma	0.048	0.026	0.0064	0.017	0.027	0.010	NA	0.015	0.0230	0.0061	0.062	NA	0.032

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Ovarian Cancer	25.5	33.7	55.5	-2.7	-6.2	-7.5
Impedance of arm (left)	7.8	36.0	61.2	3.2	6.0	7.8
Blood Red Count	7.4	71.6	121.8	-0.0	-9.6	-11.0
Impedance of arm (right)	6.8	31.8	54.0	3.0	5.7	7.3
Hair/balding pattern: Pattern 4	5.2	12.7	26.1	5.1	-1.6	-3.1
Serious illness, injury or assault of a close relative in last 2 years	4.7	5.4	9.9	-1.1	-3.2	-2.3
Number of incorrect matches in round	4.5	7.5	11.3	-2.1	2.6	3.4
Impedance of whole body	4.2	21.5	42.0	0.8	4.7	6.5
Lung FEV1/FVC ratio	4.0	20.3	29.9	-5.5	-4.6	-3.2
Loud music exposure frequency	3.6	3.9	9.9	-3.1	-1.2	-0.5
Heel T-Score	3.4	26.7	39.6	3.6	6.3	5.3
Medication: Ramipril	3.3	4.2	6.8	0.5	-2.4	-2.6
Pain type(s) experienced in last month: Hip pain	3.2	4.0	5.4	-1.2	-2.3	-2.3
Ever had prostate specific antigen (PSA) test	3.1	3.6	5.7	1.2	-1.9	-2.4
Medication: Atenolol	3.0	3.7	4.7	-1.8	-1.8	-2.2
Ever highly irritable/argumentative for 2 days	3.0	3.6	9.8	-3.1	-1.0	-0.2
Arm predicted mass (left)	2.9	14.7	21.5	-3.1	-3.6	-4.6
Arm fat-free mass (right)	2.8	14.5	22.8	-2.8	-3.6	-4.8
Tense / ‘highly strung’	2.7	4.4	6.7	-0.1	-2.5	-2.6
Arm fat-free mass (left)	2.7	13.8	21.3	-2.9	-3.5	-4.6
Risk taking	2.7	4.0	5.1	-2.3	-2.1	-1.6
Age started oral contraceptive pill	2.7	3.3	9.6	3.1	0.0	-0.6
Alcohol drinker status: Previous	2.7	3.1	4.3	-1.5	-2.1	-1.7
Reaction Time	2.6	5.0	5.9	-2.2	2.1	2.4
Arm predicted mass (right)	2.6	13.5	20.2	-3.0	-3.4	-4.5
Osteoporosis (self-reported)	2.5	3.1	3.6	-1.9	-1.9	-1.5
Trunk predicted mass	2.4	13.4	22.6	-2.6	-3.3	-4.8
Knee pain experienced in last month	2.3	3.6	4.4	1.5	2.0	2.1
Bilateral oophorectomy (both ovaries removed)	2.2	2.6	3.0	1.5	1.6	1.7
Trunk fat-free mass	2.2	12.8	21.6	-2.5	-3.2	-4.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.5	7.5	-2.7	-0.2	-0.4
Primary Biliary Cirrhosis	2.1	3.0	4.0	-2.0	-1.8	-1.4
Number of treatments/medications taken	2.0	3.5	4.2	-1.7	-1.8	-2.1
Impedance of leg (right)	2.0	9.8	18.4	-1.5	3.0	4.3
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	6.4	0.7	1.8	2.5
Eye problems/disorders: None of the above	2.0	2.4	4.0	-1.1	-2.0	-1.3
Mean time to correctly identify matches	2.0	3.7	4.5	-2.0	1.7	2.1
Breast cancer (self-reported)	2.0	2.4	4.1	2.0	1.7	0.5
Tinnitus: Yes, now most or all of the time	2.0	2.3	5.3	-2.3	-1.2	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	3.0	-1.7	-1.3	-1.6
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	5.0	-2.2	-1.1	-1.0
Illnesses of mother	1.9	2.3	3.1	1.8	1.4	1.4
Average weekly red wine intake	1.9	2.8	4.5	1.3	2.1	1.4
Eye problems/disorders: Cataract	1.9	2.1	3.6	0.4	1.9	1.6
Medication: Gliclazide	1.9	2.1	3.3	-0.6	-1.6	-1.8
Ever used hormone-replacement therapy (HRT)	1.8	2.3	2.5	-1.5	1.5	1.6
Diabetes (father)	1.8	2.2	2.9	-1.7	-1.3	-1.4
Asthma	1.8	3.5	4.7	2.2	1.8	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	5.1	-2.3	-1.4	-1.0
Medication: Ventolin 100micrograms inhaler	1.8	2.3	4.0	2.0	1.2	1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	2.3	-1.3	-1.5	-1.5
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	3.8	1.9	1.6	0.6
Medication: Lansoprazole	1.7	1.9	5.7	-2.4	-0.4	-0.0
Medication: Blood pressure	1.7	3.0	6.2	0.9	-1.4	-2.5
Whole body fat-free mass	1.7	9.8	17.4	-1.8	-3.0	-4.2
Whole body water mass	1.7	9.8	17.1	-1.9	-2.9	-4.1
High blood pressure (mother)	1.6	2.3	3.6	-0.8	-1.9	-1.6
Systolic blood pressure, automated reading	1.5	4.2	9.9	1.0	-1.3	-3.1
Impedance of leg (left)	1.5	7.4	14.4	-1.5	2.4	3.8
Mouth/teeth dental problems	1.5	2.2	3.5	1.0	1.9	1.5
Pulse wave reflection index	1.5	1.9	3.3	0.9	-1.3	-1.8
Family relationship satisfaction	1.5	1.8	2.5	-0.9	-1.6	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	3.6	-1.9	0.7	1.1
Osteoarthritis (self-reported)	1.5	1.9	3.6	1.9	1.0	1.0
Eye problems/disorders: Glaucoma	1.5	1.8	2.4	1.2	1.6	1.3
Basal metabolic rate	1.5	8.3	13.8	-1.9	-2.7	-3.7
Ulcerative Colitis (UC)	1.4	2.6	4.8	0.0	1.8	2.2
Medication for hormone replacement therapy	1.4	1.6	2.3	-1.5	0.5	1.5
Length of working week for main job	1.4	1.5	2.2	-0.6	-1.4	-1.5
Birth weight of first child	1.4	2.6	3.6	1.7	-1.2	-1.9
Diabetes diagnosed by doctor	1.4	2.3	6.3	-2.5	-0.7	-0.2
Asthma (self-reported)	1.4	2.9	4.2	2.1	1.6	1.4
Mother’s age at death	1.4	1.8	5.4	2.3	0.2	0.0
Medication: Blood pressure	1.4	2.6	5.2	1.2	-1.1	-2.3
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	2.3	-1.3	-1.4	-1.5
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.6	-1.0	1.1	1.6
Supplements: Calcium	1.3	1.4	3.1	0.1	-1.1	-1.8
Irritable Bowel Disease (IBD)	1.2	2.9	5.6	-0.3	1.7	2.4
Waist Hip Ratio (WHR)	1.2	5.4	11.6	-1.2	1.8	3.4
Vitamin and mineral supplements	1.2	1.6	4.0	-2.0	-0.9	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.6	3.3	1.6	1.8	1.4
Supplements: Glucosamine	1.2	1.5	3.7	1.9	0.7	0.5
Falls in the last year	1.2	1.6	2.5	1.1	-1.6	-0.9
Mouth/teeth dental problems: Dentures	1.2	1.9	2.9	-1.1	-1.7	-1.3
Medication: Ibuprofen	1.2	1.5	2.3	-1.5	-0.9	-1.2
Heart disease (mother)	1.2	1.4	3.9	-2.0	-0.6	-0.1
Medication: Atorvastatin	1.2	1.5	2.3	-0.6	-1.5	-1.4
Bipolar Disorder (2018)	1.1	1.8	3.3	-0.3	-1.8	-1.4
Bipolar Disorder or Schizophrenia	1.1	2.6	3.8	-1.4	-1.9	-1.4
Average weekly fortified wine intake	1.1	1.3	1.9	-0.3	-1.4	-1.4
Multivitamins +/- minerals	1.1	1.4	3.0	1.7	0.9	0.6
Medication: Simvastatin	1.1	1.6	4.5	-2.1	-0.7	-0.2
Depression (self-reported)	1.1	1.4	3.9	-2.0	-0.3	-0.3
Commuting to job workplace: Car/motor vehicle	1.1	1.3	1.9	-0.3	-1.4	-1.4
Loneliness, isolation	1.1	1.6	2.7	-0.4	-1.6	-1.4
Illnesses of father: None of the above (group 1)	1.1	1.3	3.0	1.7	0.8	0.6
Depression (Nagel 2018)	1.0	1.6	2.9	-1.7	-0.8	-1.1
Age at First Birth	1.0	1.5	2.2	-1.5	0.6	1.4
Lupus	1.0	1.5	3.6	-1.9	0.1	1.0
Ulcerative Colitis	1.0	1.4	2.8	-0.3	1.1	1.7
BMI	1.0	6.0	9.0	-1.2	-2.8	-3.0
Systolic Blood Pressure	1.0	5.1	11.4	1.9	-0.4	-3.4
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.5	-0.3	-1.1	-1.6
Medication: Metformin	1.0	1.4	2.0	-1.4	-1.3	-0.6
Townsend deprivation index at recruitment	1.0	1.3	2.1	-1.4	0.3	1.4
Maternal smoking around birth	1.0	1.5	4.3	-2.1	-0.1	0.3
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.2	1.8	0.4	0.1
Qualifications: CSEs or equivalent	1.0	1.3	3.1	-0.0	0.9	1.8
Had menopause	1.0	1.3	1.6	1.2	0.9	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	4.6	-2.1	-0.6	-0.0
Glaucoma (self-reported)	1.0	1.2	1.4	0.9	1.2	1.1
Number of full brothers	1.0	1.3	2.5	-1.6	-1.0	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	2.7	-1.1	-1.6	-1.6
Miserableness	1.0	1.7	4.5	-2.1	-0.7	0.0
Wears glasses or contact lenses	1.0	1.1	1.9	-0.0	1.4	1.2
Alzheimer’s Disease (in mother)	0.9	1.1	2.6	-1.6	-0.4	-0.8
Fasting Glucose	0.9	1.1	2.9	-1.7	-0.3	-0.5
Current tobacco smoking	0.9	1.5	1.9	1.2	1.4	1.1
Body mass index (BMI)	0.9	3.8	5.8	-0.8	-2.2	-2.4
Weight	0.9	4.3	5.3	-1.9	-2.0	-2.3
Alcohol intake versus 10 years previously	0.9	1.4	2.8	-1.7	-1.1	-0.3
Worry too long after embarrassment	0.9	1.4	2.9	-1.7	-1.0	-0.7
Wheeze or whistling in the chest in last year	0.9	1.7	3.2	1.8	0.7	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	1.6	1.3	-0.4	-1.3
Pulse rate, automated reading	0.9	2.8	4.8	2.2	1.3	1.4
Medication: Bendroflumethiazide	0.9	1.3	2.5	1.2	-0.1	-1.6
Fractured/broken bones in last 5 years	0.9	1.1	1.4	1.2	0.9	1.0
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.5	-1.6	0.3	0.8
Schizophrenia vs Biploar Disorder	0.8	1.0	1.4	-0.6	1.1	1.2
Alzheimer’s Disease (including proxy)	0.8	1.2	3.4	-1.8	0.4	0.4
Taking other prescription medications	0.8	1.3	1.9	-1.4	-1.2	-0.7
High blood pressure	0.8	2.3	5.7	0.3	-1.1	-2.4
Financial difficulties in last 2 years	0.8	1.1	2.5	-1.6	-0.5	-0.8
Diabetes (self-reported)	0.8	1.3	3.7	-1.9	-0.2	0.3
Father’s age at death	0.8	1.1	2.1	0.4	1.0	1.4
Medication: Cholesterol lowering	0.8	1.2	2.6	-1.6	-0.8	-0.5
Blood clot in the leg (DVT)	0.8	1.0	1.5	0.8	-1.2	-1.0
Headache pain in last month	0.8	1.4	4.2	-2.0	-0.1	0.0
Medication: Allopurinol	0.8	1.1	2.2	0.2	1.0	1.5
Medication: Seretide 50 evohaler	0.8	0.9	1.2	1.1	0.8	0.9
Leg fat mass (right)	0.8	3.0	4.2	-2.0	-1.7	-1.4
Chest pain or discomfort	0.8	1.2	3.0	-1.7	-0.5	0.5
Hypertension (Self-reported)	0.8	2.3	5.4	0.5	-1.1	-2.3
Leg fat-free mass (right)	0.8	4.1	7.4	-0.7	-2.1	-2.7
Ever had bowel cancer screening	0.8	1.0	1.5	-1.2	-0.8	-0.9
Smoking status: Current	0.8	1.3	1.9	0.6	1.4	1.3
Leg predicted mass (right)	0.8	4.3	7.8	-0.7	-2.2	-2.8
Number of self-reported non-cancer illnesses	0.8	1.3	2.6	0.2	-1.1	-1.6
Leg fat percentage (left)	0.8	3.0	4.7	-2.2	-1.7	-1.2
Leg fat mass (left)	0.8	3.3	4.0	-2.0	-1.8	-1.6
Schizophrenia (2018)	0.7	1.4	2.5	-1.6	-1.0	-0.7
Hypothyroidism (self reported)	0.7	1.6	1.9	-1.4	1.2	1.3
Leg fat-free mass (left)	0.7	3.6	6.7	-0.7	-1.9	-2.6
Serious illness, injury or assault to yourself	0.7	0.8	1.3	0.1	-1.2	-1.1
Leg predicted mass (left)	0.7	3.5	6.3	-0.7	-1.9	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	2.9	1.7	1.1	0.7
Hip circumference	0.7	2.8	5.4	0.1	-1.8	-2.3
Hair/balding pattern: Pattern 3	0.7	1.0	2.0	0.9	-0.2	-1.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	3.0	1.7	0.7	-0.0
Gout (self-reported)	0.7	1.0	1.4	0.4	1.2	1.2
Leg fat percentage (right)	0.7	2.4	4.7	-2.2	-1.4	-0.8
Comparative body size at age 10	0.7	1.9	4.0	-2.0	-1.1	-0.6
Medication for pain relief, constipation, heartburn	0.7	1.2	1.8	1.4	-0.5	-1.2
Migraine (self-reported)	0.7	0.9	2.5	-1.6	0.1	-0.2
Medication: Omeprazole	0.7	0.9	1.4	-0.8	0.8	1.2
High cholesterol (Self-reported)	0.7	1.2	3.0	-1.7	-0.7	-0.3
Medication: Lisinopril	0.7	0.9	2.1	0.2	-0.8	-1.4
Alcohol drinker status: Never	0.7	0.9	2.4	-1.6	0.0	0.4
Pain experienced in last month	0.7	1.2	2.3	0.1	-1.1	-1.5
Heart disease (siblings)	0.7	0.9	2.4	1.5	0.4	-0.3
Prostate Cancer	0.6	0.8	1.7	-0.8	0.5	1.3
Type 2 Diabetes (T2D) (2018)	0.6	1.0	1.7	-1.0	0.6	1.3
Neuroticism	0.6	1.4	4.2	-2.0	-0.4	0.1
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.5	-1.2	-0.6	-0.7
Supplements: Zinc	0.6	0.7	2.0	1.4	0.2	0.0
Pulse rate	0.6	1.0	2.0	0.7	0.6	1.4
Lung cancer (father)	0.6	0.7	1.2	-1.0	0.3	1.1
Peak expiratory flow (PEF)	0.6	1.4	2.1	-1.4	-1.1	-0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.4	0.2	-1.0	-1.2
Angina (self-reported)	0.6	0.8	2.0	-1.4	0.2	0.5
Comparative height size at age 10	0.6	3.0	4.8	-1.1	-2.2	-1.8
Suffer from ‘nerves’	0.6	0.9	1.4	-1.2	0.5	1.0
Friendships satisfaction	0.6	0.8	2.1	-1.4	0.4	0.4
Medication for cholesterol	0.6	0.9	1.6	0.4	1.0	1.3
Commuting to job workplace: Cycle	0.6	0.8	1.2	-0.3	1.0	1.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.3	0.6	-1.1	-0.7
Depressed Affect (Nagel 2018)	0.5	1.0	1.2	-1.0	-1.1	-0.8
Neuroticism (Nagel 2018)	0.5	1.3	2.2	-1.5	-1.1	-0.6
Crohns Disease (2017)	0.5	1.1	1.5	-1.1	0.7	1.2
Major Depression (MDD)	0.5	0.6	1.9	-1.4	-0.1	-0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.7	1.6	-0.2	-1.1
Respiratory disease	0.5	1.2	2.3	1.5	0.9	0.6
Ever had hysterectomy (womb removed)	0.5	0.5	0.7	-0.8	0.7	0.6
Medication: Levothyroxine sodium	0.5	0.8	1.3	-1.1	0.5	1.0
Qualifications: None of the above	0.5	1.2	2.2	-1.1	-1.5	-0.1
Heart attack	0.5	0.6	1.0	0.2	0.9	1.0
Neuroticism score	0.5	1.0	2.0	-1.4	-1.0	-0.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.1	-1.8	-0.8	-1.0
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.4	-1.2	0.6	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.7	-1.3	-0.5	-0.1
Number of children fathered	0.5	0.6	0.8	0.8	0.9	0.6
Alcohol intake frequency.	0.5	1.1	1.5	-1.2	-1.2	-0.6
Supplements: Vitamin C	0.5	0.6	1.3	0.6	1.1	0.3
Mineral and other dietary supplements	0.5	0.7	2.0	-1.4	-0.1	-0.0
Average weekly champagne plus white wine intake	0.5	0.7	1.7	-1.3	0.3	0.5
Cholesterol lowering medication	0.5	0.8	2.0	-1.4	-0.5	-0.3
Basal cell carcinoma (self-reported)	0.5	0.6	0.8	-0.6	0.7	0.9
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.1	-0.1	0.9	1.0
Neuroticism (2016)	0.4	0.6	0.8	-0.4	-0.8	-0.9
Schizophrenia (2014)	0.4	1.0	2.2	-1.5	-0.8	-0.3
Smoking Status	0.4	0.9	1.4	0.5	1.0	1.2
Tanning	0.4	5.1	9.2	-0.6	2.4	3.0
Angina	0.4	0.6	1.6	-1.3	0.1	0.4
Sitting height	0.4	3.2	8.3	-2.9	-0.6	-0.9
Alcohol usually taken with meals	0.4	0.7	1.7	1.3	0.1	-0.6
Hair/balding pattern: Pattern 2	0.4	0.5	0.7	-0.5	-0.8	-0.8
Allergy	0.4	1.0	2.9	-1.7	-0.3	0.0
Pain all over the body in last month	0.4	0.5	0.8	-0.9	0.6	0.5
Noisy workplace	0.4	0.5	0.8	0.9	-0.9	-0.1
Qualifications: A levels/AS levels or equivalent	0.4	1.0	1.8	0.9	-0.6	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.3	-1.5	-0.8	-0.8
Neck or shoulder pain in last month	0.4	0.6	1.6	-1.3	-0.0	0.5
Leg pain on walking	0.4	0.5	0.7	0.6	0.8	0.9
Medication: Aspirin	0.4	0.5	0.7	-0.9	0.6	0.6
Smoking status: Previous	0.4	0.6	1.3	-1.1	-0.7	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.7	0.4	0.7	0.8
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.8	-0.9	0.5	0.8
Medication: Aspirin	0.4	0.5	1.0	-1.0	0.5	0.6
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.7	0.1	0.6	1.7
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.2	1.5	-0.1	-0.8
Breast Cancer	0.3	0.7	1.5	0.3	-0.8	-1.2
Mean Putamen Volume	0.3	0.3	0.7	-0.8	-0.5	0.1
Hair Pigment	0.3	7.7	13.0	3.6	-1.7	-2.7
Average weekly spirits intake	0.3	0.3	0.7	0.4	-0.3	-0.8
Pack years adult smoking proportion	0.3	0.5	0.9	-1.0	0.3	0.8
Fed-up feelings	0.3	0.5	1.3	-1.1	-0.4	0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.5	-0.0	0.7	0.7
Waist circumference	0.3	1.2	2.2	-0.7	-1.5	-0.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.9	-0.9	-0.5	-0.0
Time employed in main current job	0.3	0.3	0.6	-0.3	0.4	0.8
Worrier / anxious feelings	0.3	0.5	1.2	-1.1	-0.5	0.1
Prospective memory result	0.3	0.3	1.0	1.0	-0.1	-0.3
Medication: Paracetamol	0.3	0.5	0.6	0.8	0.4	0.8
Medication: Amlodipine	0.3	0.5	0.7	0.8	-0.3	-0.8
High blood pressure (siblings)	0.3	0.4	1.0	0.1	-0.3	-1.0
Exposure to tobacco smoke outside home	0.3	0.4	1.0	-1.0	-0.1	-0.3
Pulse wave peak to peak time	0.3	0.4	1.0	-1.0	0.2	0.3
Shortness of breath walking on level ground	0.3	0.3	0.7	0.1	0.6	0.8
Whole body fat mass	0.3	1.4	2.2	-1.5	-1.1	-0.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.6	-0.2	0.8	0.6
Illnesses of siblings: Diabetes	0.3	0.4	1.0	-1.0	0.2	0.3
Mood swings	0.3	0.5	1.2	-1.1	-0.6	0.0
Qualifications: nursing, teaching	0.3	0.5	0.9	0.7	-0.6	-0.9
Commuting to job workplace: Walk	0.3	0.4	0.9	1.0	0.4	0.1
Guilty feelings	0.3	0.4	0.9	-1.0	-0.6	-0.2
Medication: Paracetamol	0.3	0.4	1.2	1.1	-0.0	0.0
Irritability	0.3	0.4	1.0	-1.0	-0.6	-0.1
Pack years of smoking	0.3	0.4	0.9	-1.0	0.1	0.6
Worry (Nagel 2018)	0.2	0.5	0.8	-0.4	-0.9	-0.7
Alzheimer’s Disease (in father)	0.2	0.2	0.3	0.6	0.5	0.3
Crohns Disease (2012)	0.2	0.3	0.4	-0.5	0.2	0.7
Blood Platelet Count	0.2	1.8	3.8	-0.4	1.2	1.9
Cardiovascular Disease	0.2	0.7	1.7	0.5	-0.2	-1.3
Chronotype (morning person)	0.2	0.4	1.0	0.5	0.4	1.0
Hearing difficulty/problems: Yes	0.2	0.3	0.7	-0.9	-0.4	0.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	-0.7	-0.3	-0.3
Diabetes (mother)	0.2	0.3	0.6	-0.8	-0.4	-0.2
Trunk fat percentage	0.2	0.8	1.9	-0.5	0.5	1.4
Age when periods started (menarche)	0.2	0.4	1.1	-1.0	0.4	-0.1
Chronic bronchitis/emphysema (father)	0.2	0.3	0.4	-0.6	0.4	0.5
Trunk fat mass	0.2	0.7	1.8	-1.4	-0.5	-0.1
Nervous feelings	0.2	0.4	0.7	-0.8	-0.6	-0.4
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	0.7	-0.2	-0.2
Arm fat mass (right)	0.2	0.8	1.1	-0.7	-1.0	-1.0
Standing height	0.2	1.9	5.5	-2.3	0.5	0.3
Breastfed as a baby	0.2	0.3	0.5	-0.7	-0.1	-0.5
Age at first live birth	0.2	0.3	0.6	0.8	0.5	-0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	0.6	0.4	0.4
Emphysema/chronic bronchitis	0.2	0.3	0.8	0.9	0.0	-0.0
Had major operations	0.2	0.2	0.4	-0.1	-0.7	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.4	-0.2	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.7	0.2	0.7	0.8
Long-standing illness, disability or infirmity	0.2	0.3	0.4	-0.6	-0.5	-0.5
Financial situation satisfaction	0.2	0.2	0.4	0.0	0.5	0.6
Commuting to job workplace: Public transport	0.2	0.2	0.4	0.6	-0.2	-0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.7	0.8	0.1	0.3
Average weekly beer plus cider intake	0.2	0.3	0.8	-0.1	-0.0	0.9
Diastolic blood pressure, automated reading	0.2	0.6	1.4	-0.5	1.2	-0.2
Ever depressed for a whole week	0.2	0.2	0.5	-0.1	-0.7	-0.3
Myopia	0.2	0.3	0.7	0.1	-0.8	-0.3
HbA1C	0.1	0.1	0.1	0.1	-0.3	-0.3
Rheumatoid Arthritis	0.1	0.1	0.1	0.1	0.3	0.4
Blood White Count	0.1	0.4	1.2	1.1	0.1	-0.2
Height	0.1	2.8	6.4	-2.5	0.8	1.2
Lung FVC	0.1	0.7	1.0	0.9	-0.5	-1.0
Hand grip strength (left)	0.1	0.2	0.4	-0.6	0.5	-0.3
Sensitivity / hurt feelings	0.1	0.2	0.3	-0.3	0.2	0.5
Relative age of first facial hair	0.1	0.2	0.3	0.4	-0.5	-0.4
Medication: Co-codamol	0.1	0.1	0.1	0.1	-0.3	-0.4
Hand grip strength (right)	0.1	0.3	0.9	-0.3	0.9	-0.1
Relative age voice broke	0.1	0.2	0.3	0.5	-0.2	-0.4
Past tobacco smoking	0.1	0.2	0.6	0.8	0.4	-0.1
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.6	0.0	0.5
Had other major operations	0.1	0.1	0.3	0.5	-0.1	-0.1
Fluid intelligence score	0.1	0.2	0.4	0.4	0.6	-0.2
Illnesses of siblings	0.1	0.2	0.4	-0.6	-0.4	0.2
Arm fat percentage (right)	0.1	0.2	0.3	0.6	0.0	0.6
Number of live births	0.1	0.1	0.3	0.0	-0.5	-0.1
Happiness	0.1	0.1	0.1	0.1	0.3	0.3
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.1	0.2	0.6
Birth weight	0.1	0.1	0.3	0.4	-0.1	-0.5
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.5	0.3	-0.4
Body fat percentage	0.1	0.5	1.0	-1.0	-0.3	0.6
Qualifications: College or University degree	0.1	0.2	0.3	0.0	0.5	-0.5
Number of full sisters	0.1	0.2	0.4	-0.4	-0.6	-0.1
Overall health rating	0.1	0.2	0.5	0.1	-0.7	-0.2
Age at last live birth	0.1	0.2	0.4	0.6	0.4	0.2
Illnesses of father: Heart disease	0.1	0.2	0.4	-0.6	-0.2	0.2
Arm fat percentage (left)	0.1	0.4	0.6	0.7	0.3	0.7
Back pain experienced in last month	0.1	0.1	0.3	-0.3	-0.5	0.0
Arm fat mass (left)	0.1	0.6	0.7	-0.7	-0.8	-0.7
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.1	0.4	0.1
Hearing aid user	0.1	0.1	0.4	0.1	0.7	0.0
Illnesses of father: High blood pressure	0.1	0.1	0.3	0.5	0.1	-0.1
Ever smoked	0.1	0.1	0.2	0.3	-0.5	0.4
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.5	-0.0	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.0	0.3	0.9	0.3	-0.9	-0.2
Allergy or Eczema	0.0	0.1	0.2	0.4	0.2	-0.1
Severe depression (siblings)	0.0	0.1	0.1	-0.4	-0.1	-0.0
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	0.4	0.2	-0.1
Stomach or abdominal pain in last month	0.0	0.1	0.2	-0.4	0.0	-0.1
Forced vital capacity (FVC)	0.0	0.2	0.5	0.1	0.7	0.2
Forced vital capacity (FVC), Best measure	0.0	0.0	0.1	0.2	0.3	-0.1
Health satisfaction	0.0	0.1	0.1	-0.3	0.1	-0.2
Number of operations (self-reported)	0.0	0.0	0.0	0.2	-0.1	0.1

Hub : Genes

HOXD9

Models

Trait associations