Best TWAS P=3.21e-24 · Best GWAS P=2.85e-26 conditioned to 0.962
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Liver | COPS8 | 0.33 | -0.01 | enet | 32 | 0.00 | 4.1e-01 | 3.3 | -6.2 | 5.0e-10 | 0.19 | 0.06 | 0.07 | TRUE |
| 2 | GTEx | Lung | MLPH | 0.24 | 0.06 | enet | 6 | 0.06 | 1.2e-05 | -5.6 | 5.8 | 5.2e-09 | -0.44 | 0.86 | 0.01 | FALSE |
| 3 | GTEx | Prostate | MLPH | 0.33 | 0.02 | enet | 26 | 0.12 | 5.9e-04 | -1.4 | 6.9 | 6.5e-12 | -0.64 | 0.08 | 0.38 | FALSE |
| 4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | MLPH | 0.06 | 0.01 | enet | 10 | 0.02 | 3.7e-03 | -9.7 | 7.3 | 3.1e-13 | -0.75 | 0.01 | 0.88 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MLPH | 0.08 | 0.03 | blup | 95 | 0.02 | 8.7e-04 | -7.6 | -6.9 | 5.6e-12 | 0.55 | 0.07 | 0.71 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MLPH | 0.10 | 0.10 | lasso | 1 | 0.08 | 4.4e-09 | -10.2 | 10.2 | 3.2e-24 | -0.92 | 0.01 | 0.99 | TRUE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RAB17 | 0.04 | 0.01 | blup | 79 | 0.01 | 9.8e-03 | -6.8 | 6.0 | 1.8e-09 | -0.63 | 0.02 | 0.44 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | MLPH | 0.10 | 0.15 | lasso | 7 | 0.12 | 3.5e-12 | -7.8 | 8.1 | 7.7e-16 | -0.79 | 0.94 | 0.06 | FALSE |