Best TWAS P=1.95e-26 · Best GWAS P=5.18e-25 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | C2orf82 | 0.14 | 0.08 | lasso | 4 | 0.06 | 7.0e-04 | -6.6 | -7.2 | 8.4e-13 | -0.44 | 0.38 | 0.07 | FALSE |
| 2 | GTEx | Liver | PDE6D | 0.21 | 0.10 | lasso | 4 | 0.09 | 1.8e-03 | 4.0 | 5.3 | 1.1e-07 | 0.06 | 0.02 | 0.86 | TRUE |
| 3 | GTEx | Small Intestine Terminal Ileum | C2orf82 | 0.45 | -0.01 | lasso | 6 | 0.00 | 2.6e-01 | 4.9 | 5.1 | 2.7e-07 | 0.56 | 0.03 | 0.48 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NGEF | 0.03 | 0.00 | enet | 4 | 0.01 | 1.4e-02 | 7.1 | 9.3 | 1.4e-20 | 0.71 | 0.01 | 0.97 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | NGEF | 0.14 | 0.03 | lasso | 4 | 0.03 | 6.2e-03 | 10.3 | 10.6 | 1.9e-26 | 0.98 | 0.00 | 0.96 | TRUE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NGEF | 0.16 | 0.07 | blup | 130 | 0.09 | 2.7e-10 | 10.3 | 7.8 | 6.4e-15 | 0.66 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | NGEF | 0.28 | 0.11 | enet | 11 | 0.18 | 1.1e-05 | 10.2 | 7.2 | 4.8e-13 | 0.85 | 0.00 | 0.97 | FALSE |