Hub : Genes

MLPH

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.2414	0.0733	1.8e-03	0.063	NA	0.064	NA	0.064	1.3e-05	NA	1.2e-05	NA	1.2e-05
2	GTEx	Muscle Skeletal	0.1818	0.0606	1.5e-03	0.003	NA	0.007	NA	0.007	1.4e-01	NA	6.5e-02	NA	6.5e-02
3	GTEx	Prostate	0.3260	0.1090	2.1e-03	0.015	NA	0.122	NA	0.112	1.3e-01	NA	5.9e-04	NA	9.4e-04
4	TCGA	Bladder Urothelial Carcinoma	0.0570	0.0330	4.9e-03	0.014	0.018	0.024	NA	0.017	2.0e-02	9.6e-03	3.7e-03	NA	1.3e-02
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0804	0.0367	3.9e-04	0.029	0.024	0.023	NA	0.024	3.0e-04	8.7e-04	1.1e-03	NA	9.0e-04
6	TCGA	Prostate Adenocarcinoma	0.0995	0.0455	1.9e-07	0.098	0.065	0.081	NA	0.084	1.8e-10	2.5e-07	7.1e-09	NA	4.4e-09
7	TCGA	Thyroid Carcinoma	0.0980	0.0330	2.0e-09	0.153	0.099	0.123	NA	0.125	1.1e-14	7.3e-10	5.8e-12	NA	3.5e-12

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.6	1.0	2.2	1.2	-1.5	1.1	-0.2	1.3	0.6	0.2
Bipolar Disorder or Schizophrenia	0.2	0.5	1.2	1.1	0.0	1.1	0.6	0.7	0.6	-0.0
Depressed Affect (Nagel 2018)	0.8	1.6	3.3	-1.7	0.8	0.7	1.1	-1.5	0.6	1.8
Depression (Nagel 2018)	1.7	2.5	7.7	-2.8	1.1	1.5	0.8	-1.6	-0.5	1.7
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.8	0.7	1.3	-0.7	-0.5	-1.3	-0.1	0.1
Neuroticism (Nagel 2018)	0.5	1.1	5.1	-2.2	0.1	-1.2	0.2	-0.6	-0.2	1.0
Schizophrenia (2018)	0.2	0.5	1.6	0.6	1.3	0.5	0.9	-0.2	0.3	-0.2
Schizophrenia vs Biploar Disorder	0.3	0.4	1.4	0.2	0.7	-0.6	0.5	-1.2	0.6	0.3
Worry (Nagel 2018)	0.5	1.2	3.4	-1.8	-0.3	-1.8	-0.9	-0.2	-0.5	0.4
Alzheimer’s Disease (in mother)	0.5	0.5	2.5	-0.2	-0.0	-1.0	0.2	-1.6	0.2	0.3
Alzheimer’s Disease (in father)	1.0	1.1	4.7	-0.6	0.8	0.4	0.6	-2.2	0.5	1.0
Alzheimer’s Disease (including proxy)	0.7	1.0	3.5	-0.9	0.4	-1.9	-0.3	-1.3	-0.7	-0.3
Crohns Disease (2017)	1.2	2.6	10.2	0.4	0.4	-3.2	0.2	1.1	-1.3	-2.2
Irritable Bowel Disease (IBD)	1.3	3.1	17.0	0.1	-0.2	-4.1	-0.0	0.9	-1.1	-1.6
Ulcerative Colitis (UC)	0.9	1.7	10.1	0.5	-0.6	-3.2	0.1	0.3	-0.6	-1.0
Major Depression (MDD)	0.7	0.8	3.4	-0.4	1.8	-0.4	1.4	-0.0	0.2	0.1
Reaction Time	0.3	0.5	1.9	0.9	0.1	-0.2	1.4	0.9	0.2	-0.2
Verbal and Numeric Reasoning (VNR)	0.5	1.1	4.8	2.2	0.7	-0.3	-0.4	-1.2	0.5	0.5
Breast Cancer	1.2	2.9	5.4	-1.0	-0.3	2.0	1.2	-1.8	2.2	2.3
Ovarian Cancer	0.4	0.5	1.2	0.8	-0.3	-0.5	0.9	0.8	1.1	-0.2
Prostate Cancer	5.7	8.0	13.8	-1.8	-0.6	-3.5	-3.6	1.4	-3.2	-3.7
Age at First Birth	0.9	1.3	1.8	-1.0	1.2	-1.3	-0.7	1.2	-1.1	-1.3
Bipolar Disorder (2011)	0.2	0.2	1.1	0.0	0.3	1.1	0.0	-0.1	-0.3	-0.3
Body Mass Index (BMI) (2010)	0.4	0.5	1.2	0.9	-0.5	-1.1	-0.8	0.3	-0.4	-0.5
Coronary Artery Disease (CAD)	0.3	0.4	1.2	0.5	0.5	-0.7	1.1	0.0	0.6	0.3
Crohns Disease (2012)	1.2	2.0	4.0	1.4	0.2	-1.9	0.7	1.9	-0.1	-2.0
Mean Putamen Volume	0.2	0.2	0.8	0.6	-0.5	0.3	0.9	0.3	0.4	0.1
Fasting Glucose	0.4	0.4	1.4	-0.7	0.2	0.4	1.2	-0.7	0.3	0.7
HbA1C	1.8	1.9	4.9	0.5	-0.9	-0.4	1.4	-1.7	2.2	1.7
HDL Cholesterol	0.6	1.0	2.9	1.7	0.6	1.4	0.2	1.0	0.8	-0.4
LDL Cholesterol	0.2	0.3	1.4	1.2	-0.3	-0.5	0.0	-0.0	0.4	-0.5
Lupus	0.1	0.2	0.3	-0.4	0.5	-0.4	0.0	0.5	-0.3	0.6
Neuroticism (2016)	1.0	1.5	3.9	-1.6	-0.3	-2.0	-1.3	1.1	-1.1	-0.2
Primary Biliary Cirrhosis	1.1	1.6	3.5	1.6	-1.9	-0.8	-0.9	1.7	0.6	-0.6
Rheumatoid Arthritis	0.2	0.3	1.0	0.4	0.1	-1.0	-0.5	0.3	0.5	0.4
Schizophrenia (2014)	0.6	1.4	5.6	2.4	0.4	0.9	0.9	0.5	1.4	-0.1
Triglycerides	0.2	0.3	0.9	0.9	-0.4	-0.5	0.2	-0.3	0.4	0.8
Type 2 Diabetes (T2D) (2012)	2.1	2.4	5.2	1.1	-0.8	1.2	2.1	-0.6	2.3	2.0
Ulcerative Colitis	1.7	2.5	8.2	0.5	-1.3	-2.9	-0.7	2.1	-0.7	-1.4
Blood Eosinophil Count	0.3	2.6	5.8	-0.1	0.3	-1.5	2.4	-1.9	1.6	2.0
Blood Platelet Count	0.0	0.2	0.4	0.3	-0.6	-0.6	0.0	0.3	-0.4	-0.4
Blood Red Count	0.1	1.0	6.2	0.6	-0.2	2.5	0.3	-0.1	0.2	0.6
Blood White Count	0.3	2.3	7.1	2.7	-0.2	0.3	0.7	0.6	2.3	1.6
Heel T-Score	6.3	50.1	104.0	5.8	0.1	6.9	7.3	-6.9	10.2	8.1
BMI	0.3	1.6	3.2	0.8	0.9	1.8	1.4	-0.9	1.4	1.4
Height	2.0	39.4	60.5	4.2	4.0	7.0	7.7	-5.9	7.8	6.3
Waist Hip Ratio (WHR)	0.2	0.7	1.8	-1.4	0.6	0.6	-0.3	0.9	-0.7	1.1
Systolic Blood Pressure	0.3	1.7	5.6	1.2	-0.3	0.5	2.4	-1.3	1.6	0.5
Smoking Status	0.4	1.0	3.5	0.8	-0.8	0.6	0.2	-0.8	1.9	1.2
Allergy or Eczema	0.1	0.3	1.8	1.3	-0.2	-0.5	0.2	-0.3	-0.1	-0.2
Cardiovascular Disease	0.4	1.3	2.9	-0.2	-1.2	-0.6	0.7	-1.5	1.2	1.7
Hypothyroidism (self reported)	0.2	0.4	0.8	-0.7	-0.5	-0.8	0.0	0.9	-0.4	-0.6
Respiratory disease	0.5	1.2	3.5	-0.9	0.8	-1.9	-1.2	0.4	-1.3	0.3
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.2	-0.9	0.4	0.2	1.3	-1.5	0.8	1.4
Lung FEV1/FVC ratio	0.6	3.0	10.7	1.9	-1.2	3.3	0.7	1.9	1.2	0.1
Lung FVC	0.7	3.8	9.3	-0.2	-2.5	-1.9	-3.0	0.8	-1.9	-1.9
Neuroticism	0.3	0.8	2.6	-1.6	-0.1	-0.7	0.3	-0.7	0.0	1.4
Chronotype (morning person)	0.9	2.0	10.7	0.7	0.8	3.3	1.0	-0.8	0.4	0.0
Hair Pigment	0.1	2.7	7.7	0.5	-0.0	-2.1	-1.5	0.7	-1.9	-2.8
Tanning	0.2	2.1	6.0	-2.4	1.9	-0.9	0.2	-1.6	-0.6	1.1
Hand grip strength (left)	0.9	2.4	5.2	-0.2	2.1	2.3	1.6	-1.2	1.4	1.3
Number of treatments/medications taken	0.1	0.3	1.0	-0.5	-0.3	-1.0	0.4	-0.6	0.2	-0.2
Average weekly spirits intake	0.4	0.5	2.0	0.4	-1.4	0.3	-0.8	0.5	0.2	-0.5
Sensitivity / hurt feelings	0.8	1.4	7.6	-0.4	0.7	-2.8	-0.7	0.5	-0.7	-0.6
Frequency of depressed mood in last 2 weeks	1.2	1.7	2.6	-1.6	1.2	1.1	1.2	-1.6	-0.3	1.5
Hearing difficulty/problems: Yes	0.2	0.3	0.7	0.5	-0.5	0.5	-0.8	0.8	-0.6	-0.2
Relative age of first facial hair	0.3	0.7	1.7	1.1	0.2	0.9	0.7	-1.3	0.7	0.2
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	4.6	-1.7	-0.8	-1.5	-1.8	-0.2	-2.1	-1.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.1	-0.3	0.1	1.0	0.4	-0.6	0.6	0.6
Ever had hysterectomy (womb removed)	0.7	0.8	2.4	-0.9	-0.1	-1.5	-1.3	0.1	-0.6	-0.7
Systolic blood pressure, automated reading	0.7	2.0	5.6	1.5	-0.1	1.3	2.4	-1.1	1.8	0.4
Eye problems/disorders: Diabetes related eye disease	2.1	2.4	4.2	0.7	1.8	2.1	1.8	-0.9	1.3	1.7
Angina	0.5	0.6	2.8	-0.1	-0.7	0.5	0.4	-1.7	0.3	0.5
Medication for hormone replacement therapy	0.9	1.0	1.7	-0.9	1.1	-1.3	0.2	1.3	-0.9	-0.8
Vitamin and mineral supplements	1.3	1.7	4.1	0.4	0.2	1.8	1.3	-2.0	1.2	1.1
Supplements: Zinc	0.8	0.9	3.6	-0.8	1.9	-1.2	0.5	-0.2	0.2	0.4
Medication: Co-codamol	1.5	1.8	4.3	-0.0	-0.7	0.7	0.9	-2.1	1.5	2.1
Medication: Metformin	1.5	2.1	3.9	1.1	0.6	0.8	2.0	-2.0	1.6	1.5
Diabetes (father)	0.6	0.7	2.6	1.6	0.1	-0.2	0.8	-0.4	1.2	0.5
Diabetes (mother)	0.1	0.1	0.6	-0.1	0.1	0.8	-0.3	0.2	-0.4	-0.1
Severe depression (siblings)	1.1	1.2	2.7	-0.7	0.4	-1.5	0.9	-1.6	0.7	1.4
Pack years adult smoking proportion	0.3	0.4	2.1	-0.4	-1.5	0.2	0.2	-0.3	0.2	0.6
Impedance of leg (right)	1.2	5.6	15.1	-1.2	0.2	-3.9	-3.0	2.5	-2.1	-1.8
Leg fat-free mass (left)	3.2	17.1	33.4	2.6	1.8	5.8	5.1	-3.8	4.5	3.9
Trunk fat percentage	0.3	1.2	3.5	0.7	1.5	1.3	1.9	-0.4	0.7	0.5
Hand grip strength (right)	1.3	3.5	8.1	0.6	2.3	2.8	1.9	-1.2	2.0	1.4
Townsend deprivation index at recruitment	0.4	0.5	1.1	-0.4	0.8	0.7	-0.3	0.4	-1.1	-1.0
Current tobacco smoking	0.6	0.9	4.5	-0.2	-2.1	-0.0	-0.4	-0.1	0.6	1.2
Average weekly fortified wine intake	0.8	1.0	2.5	0.6	0.1	1.2	1.6	-0.0	1.6	0.2
Maternal smoking around birth	1.7	2.5	9.3	-0.4	1.2	-3.1	-0.7	0.8	-1.7	-1.5
Fed-up feelings	0.2	0.3	1.3	-0.4	0.1	0.1	0.1	-0.6	-0.5	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	4.3	-2.1	0.5	0.7	0.7	-0.4	-0.3	1.3
Relative age voice broke	0.8	1.3	4.6	0.1	-0.4	2.1	1.1	-1.1	1.2	0.5
Taking other prescription medications	0.9	1.4	5.0	-2.2	0.3	-1.6	-1.1	-0.1	-0.9	0.2
Age when periods started (menarche)	0.3	0.8	4.5	-0.4	0.5	-2.1	0.2	0.5	-0.1	-0.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.2	0.4	-0.7	-0.7	-1.1	0.2	-0.4	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.1	12.0	3.2	-1.1	2.5	2.5	-1.9	3.5	1.8
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	0.1	0.6	-0.4	0.4	-0.1	-0.5	-0.0
Qualifications: CSEs or equivalent	0.8	1.0	3.8	1.1	0.5	0.1	1.9	0.3	1.2	0.7
Serious illness, injury or assault to yourself	0.8	1.0	2.6	-0.9	0.3	-1.2	-1.6	0.1	-1.1	-0.8
High blood pressure	1.2	3.4	6.9	0.9	-0.8	1.5	2.5	-1.7	2.6	1.9
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.3	0.7	0.3	-1.1	0.1	-0.1	-0.5	-0.3
Multivitamins +/- minerals	1.9	2.4	4.4	-0.9	-0.0	-1.9	-1.8	2.1	-1.4	-1.7
Stomach or abdominal pain in last month	0.2	0.2	0.4	-0.0	-0.5	-0.4	0.6	-0.3	0.5	0.6
Supplements: Glucosamine	0.6	0.8	2.2	-1.5	0.1	-0.4	-1.1	0.8	-1.0	-0.5
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	8.4	0.1	-2.9	-0.4	-1.3	-1.3	0.5	0.7
Medication: Atenolol	0.4	0.5	0.9	-0.2	0.7	0.6	1.0	0.2	0.9	1.0
Medication: Levothyroxine sodium	0.5	0.8	2.7	-1.6	-0.9	0.7	0.9	-0.6	0.5	0.6
Sitting height	2.4	17.3	35.4	4.3	1.7	4.9	4.2	-2.9	6.0	3.9
Chronic bronchitis/emphysema (father)	0.7	0.8	2.6	0.8	-0.7	-0.2	0.6	1.6	-0.4	-1.1
High blood pressure (mother)	0.2	0.2	0.6	-0.4	-0.2	0.6	0.2	-0.6	0.1	-0.8
Body mass index (BMI)	0.5	2.3	5.3	0.5	0.8	2.3	2.0	-1.4	1.2	1.5
Impedance of leg (left)	1.0	4.9	14.3	-0.9	0.0	-3.8	-2.5	2.6	-1.8	-1.7
Leg predicted mass (left)	3.3	17.4	33.3	2.6	1.8	5.8	5.2	-3.9	4.5	4.0
Trunk fat mass	1.0	4.2	9.6	1.3	2.0	2.6	3.1	-1.3	1.9	1.5
Waist circumference	1.1	4.1	7.5	1.1	1.7	2.7	2.7	-1.5	1.7	2.1
Number of incorrect matches in round	0.7	1.2	2.1	0.9	0.7	-1.5	-1.0	1.1	-0.9	-1.3
Past tobacco smoking	0.8	1.5	3.8	-0.3	-0.4	-1.2	-0.9	2.0	-1.7	-1.1
Alcohol usually taken with meals	0.2	0.4	1.4	-0.5	1.2	0.2	0.5	-0.8	0.2	-0.3
Nervous feelings	0.3	0.5	1.8	-0.5	-0.1	-1.3	-0.3	0.8	-0.9	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.1	-1.4	1.4	0.0	0.7	-0.4	-0.3	0.9
Hearing difficulty/problems with background noise	0.4	0.6	1.7	-0.1	0.4	1.3	-0.3	1.1	-0.7	-0.8
Hair/balding pattern: Pattern 2	1.4	1.7	3.9	0.4	0.1	0.5	2.0	-1.4	1.7	1.7
Had menopause	0.8	1.0	3.1	-0.3	-1.5	-0.1	-1.8	-0.3	-0.6	-0.8
Had other major operations	0.1	0.1	0.5	-0.2	0.2	0.5	0.7	-0.2	-0.3	-0.1
Forced vital capacity (FVC)	0.5	2.0	3.2	1.8	0.2	1.8	1.8	-1.5	1.4	0.7
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.7	11.6	2.4	-0.3	2.5	2.4	-2.4	3.4	2.3
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	5.6	-0.5	1.9	-0.5	2.4	-0.4	0.1	0.4
Qualifications: None of the above	0.5	1.2	4.3	-1.2	0.4	-0.6	-2.1	0.7	-1.1	-0.3
Financial difficulties in last 2 years	0.4	0.6	1.1	-1.1	0.5	-0.9	0.2	-0.9	-0.1	1.0
Mouth/teeth dental problems	0.4	0.6	2.0	-0.8	-0.0	-0.2	-1.4	0.7	-0.6	-0.9
Heart attack	1.4	1.7	4.4	-2.1	0.8	-1.0	-2.1	-0.7	-1.2	-0.4
Allergy	0.3	0.7	2.9	0.3	-0.9	1.7	0.4	-0.1	0.9	0.1
Pain all over the body in last month	0.7	0.8	2.0	-1.4	-0.7	-0.8	-0.2	-0.1	-0.3	1.4
Diabetes (self-reported)	0.3	0.5	1.8	0.2	1.0	-0.4	0.5	-1.3	0.3	0.5
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.7	-0.1	-0.2	-0.9	-1.6	0.8	-0.9	-0.6
Medication: Ramipril	0.3	0.4	1.2	0.7	0.0	0.5	-0.9	0.0	-0.2	-1.1
Medication: Simvastatin	1.1	1.6	5.4	-0.2	0.3	-0.4	1.9	-2.3	1.0	1.1
Fluid intelligence score	0.5	1.1	3.2	1.7	1.8	-0.7	0.1	-1.0	0.4	0.3
Illnesses of siblings	0.2	0.3	0.8	0.9	0.4	-0.9	-0.1	0.6	0.1	-0.4
Neuroticism score	0.4	0.8	2.0	-0.9	0.1	-1.4	0.6	-0.7	0.0	1.3
Weight	2.3	11.5	22.0	2.0	2.1	4.7	4.4	-2.8	3.5	3.3
Impedance of arm (right)	1.6	7.3	14.4	-0.5	0.6	-3.8	-2.0	3.1	-3.2	-3.4
Arm fat percentage (right)	0.2	0.7	2.6	0.6	1.1	0.9	1.6	0.2	-0.2	-0.2
Trunk fat-free mass	3.1	17.9	34.3	2.5	2.1	5.9	5.2	-3.6	4.8	4.2
Hip circumference	0.7	3.2	7.0	1.6	1.8	2.1	2.6	-1.2	1.6	1.2
Time employed in main current job	0.1	0.1	0.5	0.5	-0.2	0.4	0.1	0.1	-0.1	-0.7
Alcohol intake versus 10 years previously	0.6	0.9	2.3	-0.7	-1.3	1.5	-0.5	-0.7	0.7	0.8
Father’s age at death	0.3	0.5	1.7	-0.5	-0.7	-0.0	-1.3	-0.3	-0.6	-0.7
Worrier / anxious feelings	0.3	0.6	2.6	-0.6	0.7	-1.6	0.1	-0.7	-0.6	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	4.6	-1.6	1.4	-2.1	0.3	0.2	-1.2	0.4
Falls in the last year	0.3	0.3	0.8	0.7	0.1	0.2	0.5	0.9	-0.3	-0.9
Hair/balding pattern: Pattern 3	1.1	1.7	6.1	-0.3	-0.8	-2.5	-1.4	0.2	-1.4	-0.9
Number of live births	5.5	7.8	13.8	1.5	1.0	3.7	2.7	-2.5	3.4	3.5
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	5.4	1.5	0.1	2.3	1.9	-0.8	1.1	0.6
Pulse rate	1.5	2.6	10.2	-1.3	-0.8	-0.4	-3.2	1.0	-1.8	-1.1
Happiness	0.2	0.2	0.8	-0.0	-0.5	-0.5	0.1	0.9	-0.4	-0.5
Noisy workplace	1.4	1.7	2.7	1.2	0.1	1.6	1.4	-1.1	1.6	1.5
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.3	-0.5	1.0	-0.2	1.8	-0.8	0.4	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.1	-0.1	-0.4	-0.2	0.4	-0.4	0.4
Mouth/teeth dental problems: Dentures	0.4	0.7	1.9	1.0	-0.3	0.9	1.4	-0.6	0.7	0.6
Asthma	0.4	0.8	2.2	-0.2	1.5	-0.8	-1.4	0.4	-0.6	-0.1
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	5.4	-0.2	2.1	-2.3	0.3	-0.2	-0.2	-0.6
Medication: Cholesterol lowering	1.6	2.5	6.9	-0.4	0.9	0.7	2.0	-2.6	1.4	1.8
Depression (self-reported)	0.2	0.3	0.7	-0.6	0.3	0.2	-0.5	-0.7	-0.8	0.3
Medication: Lansoprazole	0.9	1.0	4.3	0.2	-1.1	-2.1	-0.8	0.3	-0.7	-0.1
Prospective memory result	0.4	0.4	2.7	-0.0	-1.7	-0.1	-0.6	0.0	-0.2	-0.1
Lung cancer (father)	0.6	0.7	1.7	1.3	-0.5	1.3	-0.2	-0.0	1.1	-0.1
Illnesses of mother	0.3	0.3	0.8	-0.3	-0.4	-0.9	-0.2	0.8	-0.6	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.4	1.1	0.1	1.5	1.4	-1.2	0.7	0.5
Pulse wave Arterial Stiffness index	1.4	1.6	3.7	1.6	-1.5	1.9	-0.0	0.6	1.5	0.2
Impedance of arm (left)	1.4	6.3	10.8	-0.5	0.1	-3.3	-2.5	2.9	-3.0	-3.1
Arm fat mass (right)	0.7	3.0	7.1	1.0	1.5	2.7	2.5	-1.0	1.3	1.2
Trunk predicted mass	3.1	17.8	34.3	2.5	2.1	5.9	5.2	-3.5	4.8	4.2
Standing height	1.9	18.8	33.3	3.2	2.9	5.8	5.2	-2.8	5.2	4.1
Length of working week for main job	1.1	1.2	2.0	1.2	0.7	1.1	1.4	-0.8	1.1	1.1
Exposure to tobacco smoke at home	0.9	1.1	2.4	0.9	0.8	1.0	1.5	-0.7	1.2	0.8
Breastfed as a baby	0.6	0.7	4.0	0.2	-0.4	0.3	-2.0	0.7	-0.5	-0.3
Tense / ‘highly strung’	0.2	0.4	1.5	-0.4	0.7	-1.2	0.7	-0.0	-0.2	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.6	0.0	0.1	-1.3	0.0	-0.6	-0.9	-0.7
Hair/balding pattern: Pattern 4	0.4	1.0	2.8	-0.2	-1.0	-0.2	-1.2	1.7	-0.4	-1.2
Birth weight of first child	0.8	1.4	4.1	0.4	-0.5	-1.0	-2.0	1.1	-1.4	-1.3
Peak expiratory flow (PEF)	0.3	0.6	2.4	0.2	0.6	1.6	1.3	0.0	0.4	-0.2
Pulse wave reflection index	0.3	0.4	1.1	0.9	-1.1	0.2	0.7	0.1	0.6	-0.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.7	0.2	-0.6	-1.2	0.3	-1.1	0.7	1.3
Loud music exposure frequency	1.0	1.1	4.3	-0.9	-2.1	-1.0	-0.8	0.3	-0.8	0.3
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	5.1	0.6	-0.4	2.0	2.2	-0.6	2.3	1.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.1	-0.5	0.9	-1.0	0.7	-1.0	-0.5	0.5
Blood clot in the leg (DVT)	0.9	1.2	6.6	-0.4	2.6	0.1	0.5	-0.8	-0.8	0.4
Medication: Paracetamol	1.2	2.0	8.2	1.1	-0.9	-2.9	-0.8	1.2	-0.9	-1.0
Headache pain in last month	0.6	1.0	3.3	-0.2	-0.4	-1.8	-1.1	0.5	-1.1	-0.8
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	6.6	0.8	-0.3	-0.5	-1.3	2.6	-0.7	-1.3
Glaucoma (self-reported)	3.2	3.7	8.4	2.1	-0.7	2.9	1.9	-1.3	2.2	1.8
Gout (self-reported)	1.0	1.4	4.5	-0.7	0.1	0.1	1.0	-1.5	1.3	2.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.7	-1.3	-0.3	1.1	0.3	-0.2	0.1	0.3
Medication: Amlodipine	1.1	1.5	3.4	0.9	-0.2	1.1	1.3	-1.8	1.3	1.2
Medication: Ventolin 100micrograms inhaler	1.9	2.4	4.1	-1.8	0.6	-1.6	-2.0	1.7	-1.7	-0.9
Birth weight	0.1	0.2	0.4	-0.3	0.5	-0.2	-0.7	0.1	0.1	0.5
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.0	0.4	1.4	0.4	1.4	-0.7	0.5	0.9
High blood pressure (siblings)	0.5	0.7	3.0	0.1	-1.7	-0.0	-1.0	0.4	-0.7	-0.7
Forced vital capacity (FVC), Best measure	0.3	1.1	2.2	1.5	0.2	1.2	1.1	-1.5	0.8	0.4
Body fat percentage	0.2	1.0	3.3	0.7	1.2	0.9	1.8	-0.4	0.6	0.6
Leg fat percentage (right)	0.2	0.6	1.3	0.5	1.1	0.6	1.1	-0.5	0.5	0.5
Arm fat-free mass (right)	3.7	18.9	35.8	2.4	1.3	6.0	5.0	-3.9	5.2	4.8
Exposure to tobacco smoke outside home	0.6	0.9	1.8	1.1	0.8	-1.3	1.2	-0.8	0.1	0.0
Comparative body size at age 10	0.1	0.4	1.0	0.3	-0.9	0.3	-1.0	0.4	-0.1	-0.6
Number of full brothers	1.1	1.4	6.2	-0.1	2.5	1.7	0.2	0.4	-0.0	0.7
Worry too long after embarrassment	0.6	1.0	4.0	0.0	0.7	-2.0	0.3	0.9	-0.7	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	3.8	0.0	-0.4	-1.9	0.2	-0.3	-0.4	-0.4
Wheeze or whistling in the chest in last year	1.3	2.3	6.7	-0.8	1.1	-2.6	-1.6	1.6	-1.3	-0.8
Number of children fathered	1.5	1.7	4.3	0.9	1.3	1.2	2.1	-1.2	1.3	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.7	0.3	1.2	-1.2	1.0	0.6	-0.7	-1.3
Age at first live birth	1.0	1.7	7.9	-2.8	0.8	-1.7	-0.2	0.2	-0.8	0.5
Pulse wave peak to peak time	1.0	1.2	2.8	-1.2	1.7	-1.4	0.5	-1.0	-0.8	0.3
Health satisfaction	1.2	1.5	4.5	-1.7	-0.7	-0.5	1.0	-1.2	0.5	2.1
Shortness of breath walking on level ground	1.0	1.2	3.5	-1.9	-0.4	-1.8	-0.1	-0.8	-0.5	0.7
Qualifications: College or University degree	0.2	0.7	2.9	0.1	0.9	-1.7	0.1	0.4	-0.6	-0.8
Eye problems/disorders: None of the above	3.0	3.4	8.8	-1.8	-1.1	-3.0	-2.0	-0.3	-2.1	-1.4
Mouth/teeth dental problems: Loose teeth	1.0	1.2	6.8	2.6	-0.6	0.4	0.2	0.6	0.8	0.2
Emphysema/chronic bronchitis	0.8	0.9	1.7	-0.8	1.3	-0.1	1.1	-1.0	0.5	1.2
Medication for pain relief, constipation, heartburn	0.6	1.1	6.8	-0.1	-0.0	2.6	0.1	0.1	0.7	0.5
Neck or shoulder pain in last month	0.6	0.8	2.9	-0.5	1.7	-0.8	1.1	0.0	0.6	0.7
Medication: Blood pressure	0.6	1.0	4.6	-0.2	-0.1	0.2	1.1	-2.1	0.5	0.8
Angina (self-reported)	0.4	0.6	2.7	-0.5	-0.8	0.4	0.2	-1.6	0.1	0.3
Migraine (self-reported)	0.5	0.6	2.4	0.9	-1.5	0.2	-0.3	0.9	0.7	-0.2
Medication: Ibuprofen	0.8	0.9	4.5	-0.3	1.2	-2.1	0.1	-0.3	-0.2	-0.5
Medication: Allopurinol	1.2	1.6	5.7	-0.6	-0.1	0.5	0.8	-2.4	1.0	1.8
Medication: Omeprazole	0.6	0.7	1.4	-1.0	-0.8	-1.2	0.5	0.5	-1.0	-0.3
Medication: Seretide 50 evohaler	0.4	0.5	2.5	0.3	-1.6	-0.0	0.4	0.5	0.5	0.6
Mean time to correctly identify matches	0.2	0.4	1.3	0.7	-1.1	0.0	0.5	0.7	0.1	-0.5
Heart disease (mother)	0.9	1.1	2.6	1.6	-1.3	1.2	-0.4	0.1	1.3	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.4	-1.2	0.8	0.5	-0.9	0.7	-1.0	-0.7
Whole body fat mass	1.0	4.2	9.7	1.6	1.8	2.5	3.1	-1.3	2.0	1.6
Leg fat mass (right)	0.9	3.4	6.5	1.3	1.5	2.3	2.5	-1.4	1.9	1.6
Arm predicted mass (right)	3.4	17.5	31.6	2.5	1.3	5.6	4.8	-3.7	5.1	4.5
Pulse rate, automated reading	0.3	0.9	2.7	-0.4	0.0	-1.6	-1.6	-0.3	-0.9	0.0
Alcohol intake frequency.	0.2	0.5	1.3	-0.2	-0.5	0.8	-0.5	1.1	-0.7	-0.7
Comparative height size at age 10	2.3	12.5	23.3	1.1	3.0	4.1	4.8	-2.3	4.1	4.0
Number of full sisters	0.5	0.6	1.3	0.4	1.2	1.0	0.9	-0.8	0.3	0.1
Suffer from ‘nerves’	0.8	1.2	3.1	-1.8	-0.6	-1.2	-1.6	-0.5	-0.6	0.7
Overall health rating	0.5	1.0	2.9	-1.7	0.2	-0.7	-0.2	-1.3	-0.7	1.2
Chest pain or discomfort	1.3	1.9	4.9	-0.9	1.3	-2.2	-0.7	0.9	-1.7	-1.3
Had major operations	0.7	0.8	2.4	-1.1	-0.3	1.6	0.1	-0.4	0.3	1.2
Age at last live birth	1.2	1.8	7.6	-2.8	1.5	-1.0	0.2	-0.2	-1.0	0.9
Family relationship satisfaction	0.5	0.6	1.9	1.1	-1.4	-0.0	-0.0	0.7	0.5	0.2
Leg pain on walking	1.2	1.5	2.7	0.6	1.2	-0.2	1.4	-1.2	1.6	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	2.8	-0.3	-0.6	0.8	1.7	-1.0	0.9	1.3
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	-0.4	0.6	-0.2	0.6	-0.2	0.1	0.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.1	0.5	-0.1	1.4	0.9	-0.9	1.2	0.6
Medication: Aspirin	0.6	0.9	3.8	-1.9	0.2	-0.1	0.0	-1.1	-0.4	0.8
Supplements: Vitamin C	0.6	0.7	2.2	0.4	0.4	-0.9	0.5	-0.8	1.5	0.8
Knee pain experienced in last month	0.2	0.4	1.2	0.3	0.2	-1.1	1.1	0.1	-0.0	0.1
Hypertension (Self-reported)	1.1	3.1	6.4	1.0	-0.7	1.4	2.3	-1.7	2.5	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	0.5	-0.2	0.3	0.3	0.3	-0.5	0.0
Illnesses of father: Heart disease	0.7	1.0	1.9	-1.2	0.9	-1.1	1.4	-0.9	0.5	0.8
Illnesses of siblings: Diabetes	2.1	2.6	6.1	-0.1	0.8	1.3	2.5	-1.8	1.6	2.0
Smoking status: Previous	1.0	1.5	3.2	0.7	1.0	1.8	0.6	-1.3	1.7	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	5.7	1.9	2.3	2.4	2.0	-0.4	1.8	1.1
Whole body fat-free mass	3.4	19.4	37.7	2.5	1.9	6.1	5.4	-3.9	5.0	4.4
Leg fat-free mass (right)	3.4	18.0	34.8	2.8	1.6	5.9	5.4	-3.7	4.7	4.0
Arm fat percentage (left)	0.1	0.6	1.9	0.8	0.9	0.9	1.4	0.1	-0.0	-0.1
Average weekly red wine intake	0.2	0.3	0.9	0.1	0.9	0.4	0.9	0.2	0.6	0.4
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.3	-1.1	1.1	0.0	0.4	-0.3	-1.0	-0.3
Mood swings	0.2	0.4	1.3	-0.9	0.5	-0.4	0.5	-0.4	0.1	1.1
Loneliness, isolation	0.6	0.9	3.3	-0.9	-0.3	0.1	0.9	-1.8	0.1	1.1
Long-standing illness, disability or infirmity	0.8	1.2	4.5	-0.4	-0.5	-2.1	-0.3	0.2	-1.6	-0.9
Ever had bowel cancer screening	0.4	0.5	1.8	-1.2	0.3	-0.2	-0.2	-1.3	0.1	0.4
Diabetes diagnosed by doctor	0.9	1.5	3.2	-0.2	0.9	1.0	1.3	-1.8	1.1	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.4	0.7	0.3	0.0	1.1	-0.3	1.2	1.0
Friendships satisfaction	0.6	0.7	3.4	0.8	-0.7	0.6	0.4	1.8	0.2	0.1
Qualifications: nursing, teaching	0.1	0.2	0.4	0.1	0.6	-0.4	0.6	0.0	-0.3	-0.2
Commuting to job workplace: Walk	0.4	0.4	1.9	0.6	0.6	1.4	-0.1	0.2	0.4	0.3
Eye problems/disorders: Cataract	1.4	1.6	8.2	0.7	1.0	2.9	0.5	0.9	0.6	0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.0	0.3	1.0	-0.8	0.8	0.2	0.4	-0.4
Medication for cholesterol	0.0	0.1	0.1	0.3	0.2	0.3	0.2	0.3	0.2	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	0.2	-0.6	-0.2	0.2	-0.2	0.2	0.2
Back pain experienced in last month	1.6	2.4	6.0	-0.9	0.2	0.8	2.4	-1.4	1.6	2.2
Mineral and other dietary supplements	1.2	1.6	4.2	2.0	-0.6	1.1	1.1	-1.3	1.5	0.3
Breast cancer (self-reported)	0.5	0.6	1.6	0.3	-1.3	-0.9	-0.7	0.5	-0.5	-0.8
Asthma (self-reported)	0.4	0.8	2.2	-0.3	1.2	-1.1	-1.5	0.4	-0.7	-0.2
Osteoporosis (self-reported)	3.6	4.4	9.2	-1.8	-1.8	-1.6	-3.0	2.0	-2.5	-1.6
Osteoarthritis (self-reported)	1.3	1.7	4.9	0.1	-1.0	0.1	1.0	-1.4	2.2	1.6
Medication: Aspirin	0.6	0.8	2.7	-1.7	0.4	0.3	0.3	-1.5	-0.1	0.7
Medication: Gliclazide	2.4	2.7	6.9	0.1	0.2	2.6	2.2	-1.2	1.9	1.4
Illnesses of father: None of the above (group 1)	1.2	1.4	4.0	-0.6	-0.5	0.6	-2.0	1.2	-1.5	-1.2
Smoking status: Current	0.6	0.9	3.8	-0.4	-2.0	-0.5	-0.3	-0.4	0.6	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.5	-0.7	-0.6	-0.0	-1.5	0.1	-1.6	-1.4
Whole body water mass	3.5	19.9	37.7	2.6	1.9	6.1	5.5	-4.0	5.0	4.5
Leg predicted mass (right)	3.3	17.8	34.5	2.7	1.6	5.9	5.4	-3.7	4.7	4.0
Arm fat mass (left)	0.8	3.2	8.1	1.1	1.5	2.9	2.5	-1.1	1.3	1.2
Number of self-reported non-cancer illnesses	0.9	1.6	5.3	-2.3	0.5	-1.5	-0.8	0.0	-1.7	-0.3
Average weekly champagne plus white wine intake	0.3	0.5	1.5	-1.2	0.6	-0.7	-0.8	-0.2	-0.5	0.2
Miserableness	1.2	2.0	4.6	-2.1	0.7	-0.4	1.3	-2.1	0.3	1.6
Guilty feelings	0.5	0.7	1.9	-1.4	0.9	-0.2	0.5	-0.7	-0.2	1.1
Wears glasses or contact lenses	0.3	0.3	1.3	-1.1	-0.3	0.6	0.2	-0.2	-0.0	0.6
Ever taken oral contraceptive pill	1.8	2.0	6.5	-0.1	1.0	-0.0	1.3	-2.5	1.3	1.7
Hearing aid user	3.0	3.4	6.6	-0.2	-1.2	0.7	2.2	-2.6	2.0	2.5
Mother’s age at death	0.9	1.1	4.0	-0.8	1.5	2.0	0.7	0.2	0.2	0.4
Financial situation satisfaction	0.9	1.1	3.9	-1.7	0.0	-0.1	2.0	-0.2	-0.2	0.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.4	0.2	-1.2	0.8	-1.1	-0.4	-0.8	-0.4
Commuting to job workplace: Public transport	0.4	0.4	1.1	-0.3	0.6	-0.5	0.9	-0.3	-1.1	-0.6
Eye problems/disorders: Glaucoma	3.2	3.8	6.8	2.6	-0.8	2.2	2.4	0.0	2.4	1.7
Medication: Blood pressure	0.6	1.2	2.5	0.5	-0.1	1.5	1.1	-1.0	1.6	1.1
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.8	-1.7	0.9	-1.1	-0.7	0.2	-1.3	-0.8
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.8	-1.4	0.4	0.3	1.0	-0.5	0.3	1.1
High cholesterol (Self-reported)	0.2	0.4	0.9	-0.9	-1.0	-0.2	0.2	-0.7	-0.3	-0.1
Medication: Bendroflumethiazide	0.9	1.3	2.8	0.4	-1.7	1.1	1.4	-1.3	1.1	0.5
Medication: Paracetamol	0.4	0.6	3.1	0.6	-0.9	-1.8	-0.2	0.2	-0.2	-0.2
Medication: Lisinopril	1.0	1.3	3.8	-0.1	0.1	1.2	-0.3	-1.9	0.5	1.8
Medication: Atorvastatin	0.4	0.5	1.9	-0.7	-1.4	0.3	-0.7	-0.8	0.1	0.4
Illnesses of father: High blood pressure	2.0	2.4	4.7	0.1	-0.1	1.2	2.0	-2.2	1.8	1.9
Alcohol drinker status: Never	0.5	0.5	1.6	0.8	-0.8	1.3	-0.1	0.4	0.6	0.6
Ever smoked	0.7	1.3	4.0	-0.2	-0.2	0.6	0.7	-2.0	1.5	1.4
Basal metabolic rate	3.3	18.3	34.6	2.5	2.1	5.9	5.4	-3.8	4.7	4.2
Leg fat percentage (left)	0.2	0.8	2.6	0.7	1.1	0.7	1.6	-0.5	0.6	0.5
Arm fat-free mass (left)	3.4	17.5	32.9	2.0	1.8	5.7	5.1	-3.7	4.7	4.4
Number of operations (self-reported)	0.7	1.0	3.7	-0.7	0.8	1.9	0.8	-0.1	0.6	1.1
Average weekly beer plus cider intake	1.8	2.5	8.4	0.8	0.1	1.4	0.9	-1.6	1.9	2.9
Irritability	0.8	1.3	3.2	-1.4	-1.1	-1.8	1.0	-0.0	-0.4	1.3
Risk taking	0.6	0.9	3.0	0.4	1.2	-0.3	1.7	-1.1	0.3	0.3
Ever had prostate specific antigen (PSA) test	0.7	0.8	3.4	0.2	0.6	-0.6	0.2	1.8	-0.5	-0.9
Fractured/broken bones in last 5 years	0.8	1.0	3.7	-0.3	0.2	1.9	0.6	-1.1	0.7	1.0
Age started oral contraceptive pill	0.2	0.3	0.8	0.9	0.3	-0.2	-0.6	-0.3	0.2	-0.6
Diastolic blood pressure, automated reading	0.6	1.7	5.2	2.3	1.0	0.6	2.1	-0.3	1.0	0.0
Ever depressed for a whole week	0.7	0.9	2.0	-0.9	1.4	-1.4	0.5	-0.6	-0.6	-0.7
Unable to work because of sickness or disability	0.2	0.3	1.2	-0.2	0.3	-0.0	-0.5	-0.6	-0.0	1.1
Commuting to job workplace: Cycle	1.5	1.8	3.7	-0.1	1.9	-0.8	-1.8	0.9	-1.6	-1.3
Myopia	1.5	2.2	4.5	0.1	2.1	-0.6	-0.4	1.2	-2.1	-2.1
Vascular/heart problems diagnosed by doctor	0.7	2.0	4.1	-0.1	0.6	-1.0	-1.8	2.0	-1.8	-1.5
Cholesterol lowering medication	0.4	0.6	2.1	-1.1	-0.7	-0.1	-0.2	-1.4	-0.7	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.1	-1.2	-1.5	-0.4	-0.2	0.9	-1.1	0.1
Pain experienced in last month	0.8	1.3	3.1	1.4	-1.1	1.8	-0.8	-0.2	-0.3	-1.4
Supplements: Calcium	5.8	6.4	13.4	-1.7	-1.9	-1.5	-3.7	2.8	-3.2	-2.2
Basal cell carcinoma (self-reported)	1.0	1.2	2.8	1.7	-0.2	1.5	0.8	1.4	1.0	-0.1
Heart attack/myocardial infarction (self-reported)	1.4	1.9	5.4	-2.3	0.8	-0.7	-2.1	-0.6	-1.2	-0.3
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	8.6	-0.8	2.9	-0.2	0.4	-0.8	-1.1	0.2
Heart disease (siblings)	1.0	1.2	5.8	-2.4	0.2	0.9	-0.4	-0.7	-0.4	1.1
Alcohol drinker status: Previous	1.2	1.4	5.4	1.2	-0.6	0.0	2.3	-0.3	1.4	0.6
Pack years of smoking	0.3	0.4	1.5	-0.1	-1.2	0.4	0.4	-0.4	0.6	0.8
Impedance of whole body	1.3	6.5	14.1	-0.8	-0.0	-3.8	-2.7	3.0	-2.7	-2.7
Leg fat mass (left)	1.0	3.7	7.9	1.4	1.5	2.4	2.8	-1.3	2.0	1.6
Arm predicted mass (left)	3.4	17.3	32.5	2.1	1.7	5.7	5.1	-3.6	4.7	4.3