Hub : Genes

COPS8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1590	0.0550	0.0027	0.001	NA	0.033	NA	0.003	0.280	NA	0.0015	NA	0.1800
2	GTEx	Liver	0.3260	0.0950	0.0034	-0.009	NA	-0.003	NA	-0.011	0.680	NA	0.4200	NA	0.9700
3	TCGA	Brain Lower Grade Glioma	0.0453	0.0353	0.0062	0.012	0.013	0.019	NA	0.017	0.015	0.012	0.0028	NA	0.0044

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	1.0	2.7	1.6	0.3	0.6
Bipolar Disorder or Schizophrenia	0.4	0.9	2.7	1.6	0.3	0.2
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	0.0	-0.8	0.2
Depression (Nagel 2018)	0.8	1.2	1.7	-1.3	1.1	0.8
Intelligence (Savage-Jansen 2018)	0.9	2.7	4.9	-1.1	1.4	2.2
Neuroticism (Nagel 2018)	0.1	0.1	0.3	0.1	-0.6	-0.3
Schizophrenia (2018)	0.1	0.3	0.8	0.9	0.2	-0.3
Schizophrenia vs Biploar Disorder	0.2	0.2	0.6	0.3	-0.8	0.2
Worry (Nagel 2018)	0.1	0.2	0.3	0.4	-0.5	-0.5
Alzheimer’s Disease (in mother)	0.2	0.3	0.5	-0.5	0.3	0.7
Alzheimer’s Disease (in father)	0.2	0.3	0.7	0.2	-0.8	0.3
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.4	0.2	0.9
Crohns Disease (2017)	1.4	3.0	7.2	-1.2	0.4	-2.7
Irritable Bowel Disease (IBD)	0.9	2.1	4.4	-1.3	0.2	-2.1
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.6	-0.1	-0.5
Major Depression (MDD)	0.6	0.8	1.6	-0.2	0.8	-1.3
Reaction Time	2.7	5.2	14.4	-0.6	-3.8	-0.9
Verbal and Numeric Reasoning (VNR)	0.7	1.6	4.9	-0.2	0.0	2.2
Breast Cancer	0.3	0.7	1.7	-0.4	0.4	1.3
Ovarian Cancer	0.4	0.5	1.2	0.5	0.4	-1.1
Prostate Cancer	0.8	1.1	3.1	-1.8	-0.5	-0.2
Age at First Birth	0.5	0.8	1.7	1.3	0.5	0.6
Bipolar Disorder (2011)	1.1	1.0	2.0	1.1	1.4	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	0.2	-0.8	-0.5
Coronary Artery Disease (CAD)	0.9	1.1	1.5	-1.2	1.2	-0.5
Crohns Disease (2012)	1.4	2.3	6.1	-0.8	-0.1	-2.5
Mean Putamen Volume	0.7	0.8	1.6	1.3	-0.4	0.7
Fasting Glucose	0.1	0.1	0.3	-0.0	-0.5	0.3
HbA1C	1.0	1.1	2.4	-0.6	-1.5	-0.7
HDL Cholesterol	0.5	0.8	1.5	1.2	-0.7	0.6
LDL Cholesterol	0.5	0.8	1.2	1.1	0.0	1.1
Lupus	1.0	1.5	4.0	-0.2	2.0	-0.7
Neuroticism (2016)	1.3	1.8	4.8	0.5	2.2	0.6
Primary Biliary Cirrhosis	0.5	0.7	1.9	1.4	0.3	-0.1
Rheumatoid Arthritis	0.3	0.4	0.8	0.9	-0.5	-0.5
Schizophrenia (2014)	0.6	1.3	3.9	2.0	-0.2	-0.1
Triglycerides	0.3	0.4	0.7	0.9	-0.2	0.7
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.8	-0.0	0.3	-1.3
Ulcerative Colitis	0.3	0.5	1.3	-0.2	1.1	-0.1
Blood Eosinophil Count	0.3	2.6	3.1	-1.5	-1.8	-1.6
Blood Platelet Count	0.0	0.2	0.4	-0.3	-0.6	-0.2
Blood Red Count	0.3	3.0	5.5	0.9	-2.3	1.6
Blood White Count	0.8	5.6	14.4	0.6	-3.8	1.4
Heel T-Score	2.2	17.5	38.7	3.7	-6.2	-0.0
BMI	0.2	1.1	2.2	-0.8	0.6	-1.5
Height	0.1	1.1	2.3	1.1	1.5	0.1
Waist Hip Ratio (WHR)	1.5	6.9	15.2	-1.6	3.9	-1.7
Systolic Blood Pressure	0.0	0.2	0.3	0.6	0.0	-0.4
Smoking Status	0.4	1.0	1.9	1.4	-1.0	0.4
Allergy or Eczema	0.3	0.9	2.4	1.6	0.5	0.3
Cardiovascular Disease	1.0	3.2	4.8	-2.2	-0.1	-2.2
Hypothyroidism (self reported)	0.5	1.2	1.4	1.2	-1.0	1.1
Respiratory disease	0.2	0.4	0.5	0.7	0.7	0.6
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.7	-1.6	0.7	-0.3
Lung FEV1/FVC ratio	0.3	1.5	2.2	-1.4	-0.6	-1.5
Lung FVC	0.5	2.6	6.1	-1.0	-2.5	-0.8
Neuroticism	0.4	0.9	2.2	0.5	-1.5	-0.5
Chronotype (morning person)	0.0	0.1	0.1	-0.1	-0.1	-0.4
Hair Pigment	0.0	1.1	2.8	0.4	-1.7	0.5
Tanning	0.3	3.5	5.5	-1.5	2.3	1.7
Hand grip strength (left)	0.8	2.2	6.0	2.4	-0.5	0.7
Number of treatments/medications taken	0.0	0.0	0.1	0.1	0.3	-0.2
Average weekly spirits intake	0.4	0.5	1.3	0.2	0.3	-1.1
Sensitivity / hurt feelings	0.3	0.4	1.0	0.4	-1.0	0.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.7	-1.7	0.1	0.4
Hearing difficulty/problems: Yes	0.3	0.5	0.8	0.9	0.5	0.7
Relative age of first facial hair	2.1	4.3	7.7	2.8	-1.0	2.1
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	3.0	-1.7	1.0	-1.2
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.5	1.0	0.4	-1.6
Ever had hysterectomy (womb removed)	0.5	0.5	0.9	0.8	0.2	-1.0
Systolic blood pressure, automated reading	0.4	1.2	3.6	1.9	-0.0	-0.3
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	0.1	0.1	-0.3
Angina	1.6	2.1	5.9	0.0	-0.7	-2.4
Medication for hormone replacement therapy	0.1	0.2	0.3	-0.6	0.1	-0.4
Vitamin and mineral supplements	0.4	0.6	1.5	1.2	-0.1	0.5
Supplements: Zinc	1.3	1.4	2.3	-1.4	1.5	0.1
Medication: Co-codamol	1.2	1.4	3.0	-1.7	-0.2	-1.1
Medication: Metformin	1.4	2.0	3.8	-2.0	0.4	-1.5
Diabetes (father)	0.7	0.9	2.1	-0.5	0.5	-1.4
Diabetes (mother)	1.4	1.7	4.3	-0.9	0.3	-2.1
Severe depression (siblings)	0.3	0.4	1.0	0.3	0.0	1.0
Pack years adult smoking proportion	1.5	2.3	5.2	-0.9	-2.3	-0.9
Impedance of leg (right)	0.4	2.0	4.2	1.3	0.4	2.0
Leg fat-free mass (left)	0.4	1.9	5.2	-0.8	-0.1	-2.3
Trunk fat percentage	0.4	1.5	3.0	-0.7	0.9	-1.7
Hand grip strength (right)	0.7	1.8	4.5	2.1	0.2	0.9
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.3	-0.0	-0.5
Current tobacco smoking	0.5	0.9	1.5	1.0	-1.2	-0.2
Average weekly fortified wine intake	0.8	0.9	2.8	1.7	0.0	0.0
Maternal smoking around birth	1.3	1.9	4.0	-2.0	0.8	-1.0
Fed-up feelings	0.1	0.2	0.5	-0.1	0.4	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.3	-0.4	0.6	-0.2
Relative age voice broke	1.2	1.8	3.0	1.2	-0.9	1.7
Taking other prescription medications	0.2	0.4	1.0	0.3	1.0	-0.2
Age when periods started (menarche)	0.3	0.7	1.1	-0.8	1.1	0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	0.0	-0.7	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	6.9	1.1	-2.6	0.3
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.0	-1.4	-0.4	-1.2
Qualifications: CSEs or equivalent	0.2	0.3	0.4	0.7	-0.5	0.5
Serious illness, injury or assault to yourself	0.4	0.5	0.8	-0.9	0.3	-0.7
High blood pressure	1.0	2.7	6.8	-0.9	-0.6	-2.6
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.4	0.6	0.2	0.6
Multivitamins +/- minerals	0.1	0.2	0.4	-0.6	-0.3	-0.2
Stomach or abdominal pain in last month	0.2	0.3	0.5	-0.7	0.2	-0.5
Supplements: Glucosamine	1.0	1.3	2.0	-0.8	1.4	1.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	-0.1	0.3	-1.3
Medication: Atenolol	1.1	1.3	1.5	-1.2	1.1	-1.1
Medication: Levothyroxine sodium	0.5	0.9	1.9	1.4	-0.7	0.5
Sitting height	0.1	0.8	1.6	1.3	0.1	-0.8
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	-0.4	-0.4	0.0
High blood pressure (mother)	0.6	0.8	1.8	0.1	-1.3	-0.8
Body mass index (BMI)	0.6	2.7	4.2	-2.0	-0.1	-2.0
Impedance of leg (left)	0.2	1.0	1.8	0.9	0.6	1.4
Leg predicted mass (left)	0.4	2.0	5.2	-0.9	-0.1	-2.3
Trunk fat mass	0.4	1.7	3.4	-0.8	1.0	-1.8
Waist circumference	1.3	4.8	7.6	-2.8	0.6	-2.5
Number of incorrect matches in round	2.3	3.8	7.7	1.8	2.8	0.8
Past tobacco smoking	0.1	0.1	0.3	-0.5	-0.1	-0.3
Alcohol usually taken with meals	0.2	0.4	0.9	0.3	-1.0	0.4
Nervous feelings	1.1	2.1	3.0	1.7	-1.1	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.6	0.7	-1.3	0.8
Hearing difficulty/problems with background noise	0.1	0.2	0.5	-0.7	-0.1	-0.0
Hair/balding pattern: Pattern 2	1.5	1.9	4.2	-1.1	-0.6	-2.0
Had menopause	0.1	0.1	0.2	-0.3	-0.1	-0.4
Had other major operations	0.6	0.7	1.7	0.5	-1.3	-0.2
Forced vital capacity (FVC)	0.0	0.1	0.3	-0.2	-0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.4	6.4	0.9	-2.5	0.3
Ever unenthusiastic/disinterested for a whole week	2.4	2.9	5.0	-2.2	-1.0	-1.7
Qualifications: None of the above	0.1	0.3	0.6	-0.8	-0.4	0.2
Financial difficulties in last 2 years	0.8	1.1	2.9	-1.7	0.5	-0.4
Mouth/teeth dental problems	0.9	1.4	3.9	-0.5	0.3	-2.0
Heart attack	0.2	0.3	0.6	-0.3	0.7	0.5
Allergy	0.1	0.2	0.6	-0.2	-0.8	-0.3
Pain all over the body in last month	3.4	3.7	8.9	-3.0	-0.5	-1.4
Diabetes (self-reported)	1.8	2.7	6.7	-2.6	-0.0	-1.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.4	0.1	0.2	0.6
Medication: Ramipril	0.3	0.4	1.1	1.0	-0.3	0.4
Medication: Simvastatin	0.7	1.0	2.9	0.3	0.3	-1.7
Fluid intelligence score	0.3	0.6	1.6	-0.4	0.1	1.3
Illnesses of siblings	0.9	1.3	3.6	0.5	-0.4	1.9
Neuroticism score	0.5	1.1	3.0	-0.3	-1.7	-0.2
Weight	0.5	2.3	4.8	-1.3	0.5	-2.2
Impedance of arm (right)	0.4	1.9	4.0	2.0	0.4	1.3
Arm fat percentage (right)	0.3	1.0	2.3	-0.8	0.1	-1.5
Trunk fat-free mass	0.2	0.9	2.3	-0.6	0.2	-1.5
Hip circumference	0.4	1.6	2.9	-1.7	-0.5	-1.2
Time employed in main current job	0.2	0.3	0.5	0.5	-0.1	-0.7
Alcohol intake versus 10 years previously	1.4	2.1	5.0	1.1	2.2	-0.0
Father’s age at death	0.0	0.1	0.1	0.3	-0.2	0.1
Worrier / anxious feelings	0.2	0.3	0.5	-0.5	-0.7	-0.3
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	8.8	-3.0	0.8	0.4
Falls in the last year	0.6	0.8	2.0	1.4	0.4	-0.4
Hair/balding pattern: Pattern 3	0.3	0.5	0.8	-0.9	-0.4	0.6
Number of live births	0.1	0.1	0.2	0.3	0.3	0.5
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.7	-0.9	0.0	-1.3
Pulse rate	1.7	2.9	7.5	-2.7	-0.8	-0.7
Happiness	2.5	3.1	6.0	-2.5	-1.4	-1.1
Noisy workplace	0.2	0.2	0.6	-0.0	-0.8	0.1
Qualifications: A levels/AS levels or equivalent	1.1	2.5	2.9	-1.7	1.7	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.8	-0.9	0.4	-0.3
Mouth/teeth dental problems: Dentures	1.5	2.4	5.0	1.5	-0.0	2.2
Asthma	0.2	0.3	0.8	0.9	0.3	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	-0.4	0.4	0.8
Medication: Cholesterol lowering	0.5	0.8	1.4	-1.0	0.0	-1.2
Depression (self-reported)	1.8	2.2	6.2	-2.5	-0.1	0.6
Medication: Lansoprazole	0.4	0.4	0.6	-0.7	-0.5	-0.8
Prospective memory result	1.3	1.6	4.6	-0.2	-2.1	-0.5
Lung cancer (father)	0.4	0.5	0.6	0.5	-0.8	0.7
Illnesses of mother	0.5	0.6	0.8	0.8	0.6	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	3.9	-1.2	0.1	-2.0
Pulse wave Arterial Stiffness index	4.0	4.7	11.2	-0.8	-3.3	-1.4
Impedance of arm (left)	0.5	2.2	4.0	2.0	1.0	1.3
Arm fat mass (right)	0.5	2.2	4.5	-1.4	0.6	-2.1
Trunk predicted mass	0.1	0.8	2.2	-0.5	0.2	-1.5
Standing height	0.2	1.6	3.0	1.7	1.3	-0.4
Length of working week for main job	0.5	0.5	1.3	-1.1	0.2	-0.5
Exposure to tobacco smoke at home	0.9	1.0	1.8	-0.7	-0.9	-1.4
Breastfed as a baby	0.3	0.3	0.5	-0.2	0.7	0.7
Tense / ‘highly strung’	0.4	0.6	1.8	-0.2	0.1	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	3.1	-1.1	-1.8	-1.6
Hair/balding pattern: Pattern 4	0.6	1.4	2.6	1.2	0.4	1.6
Birth weight of first child	1.4	2.5	5.3	-2.3	1.0	-1.1
Peak expiratory flow (PEF)	0.6	1.4	2.4	-0.6	1.6	-1.2
Pulse wave reflection index	0.5	0.6	1.0	-0.1	-0.9	-1.0
Ever highly irritable/argumentative for 2 days	1.8	2.2	4.6	-0.9	-2.1	-1.0
Loud music exposure frequency	1.8	2.0	5.6	-2.4	-0.6	-0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	-0.7	0.2	-0.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.5	-0.0	-0.2	1.2
Blood clot in the leg (DVT)	0.7	0.9	2.3	0.2	0.5	1.5
Medication: Paracetamol	1.3	2.1	3.5	-1.9	-0.4	-1.6
Headache pain in last month	0.2	0.3	0.8	0.9	-0.4	0.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	1.8	1.3	1.1	1.0
Glaucoma (self-reported)	0.9	1.1	2.6	0.1	-1.6	-0.8
Gout (self-reported)	0.2	0.3	0.6	0.1	-0.8	-0.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	1.8	1.4	-0.8	1.2
Medication: Amlodipine	1.1	1.5	3.7	-0.4	-0.9	-1.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.4	1.2	0.6	0.8
Birth weight	0.1	0.3	0.5	0.5	-0.1	0.7
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.8	-0.5	1.3	0.4
High blood pressure (siblings)	2.6	3.7	7.0	-2.0	-0.6	-2.6
Forced vital capacity (FVC), Best measure	0.2	0.8	2.0	-0.5	-0.3	-1.4
Body fat percentage	0.2	1.0	1.8	-0.8	0.6	-1.4
Leg fat percentage (right)	0.1	0.5	1.3	-1.1	-0.1	-0.5
Arm fat-free mass (right)	0.3	1.6	3.3	-0.9	0.8	-1.8
Exposure to tobacco smoke outside home	0.2	0.2	0.6	-0.8	0.1	0.1
Comparative body size at age 10	0.3	0.8	1.3	0.9	0.6	1.1
Number of full brothers	0.1	0.1	0.2	0.1	-0.0	0.5
Worry too long after embarrassment	0.4	0.7	1.7	-0.7	-1.3	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.0	-0.3	-1.4	-0.5
Wheeze or whistling in the chest in last year	0.4	0.6	1.1	-0.6	1.0	-0.6
Number of children fathered	0.0	0.0	0.0	-0.2	-0.1	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	0.8	0.9	0.9	0.7
Age at first live birth	1.5	2.6	5.2	-1.6	2.3	-0.4
Pulse wave peak to peak time	4.1	4.8	11.5	1.0	3.4	1.4
Health satisfaction	2.0	2.6	5.4	-2.3	0.3	-1.5
Shortness of breath walking on level ground	0.3	0.4	0.7	-0.6	0.2	-0.8
Qualifications: College or University degree	0.0	0.1	0.1	0.2	0.3	-0.3
Eye problems/disorders: None of the above	0.8	1.0	1.4	-1.2	1.0	-0.6
Mouth/teeth dental problems: Loose teeth	2.7	3.2	4.9	-0.9	-2.2	-2.0
Emphysema/chronic bronchitis	2.2	2.5	5.4	1.2	2.3	-0.7
Medication for pain relief, constipation, heartburn	0.9	1.6	3.4	1.8	-0.0	1.2
Neck or shoulder pain in last month	0.3	0.4	1.2	-0.4	0.1	-1.1
Medication: Blood pressure	1.4	2.5	3.8	-1.1	-1.9	-1.6
Angina (self-reported)	1.5	1.9	5.5	-0.1	-0.5	-2.4
Migraine (self-reported)	1.2	1.5	3.6	-0.9	-1.9	0.5
Medication: Ibuprofen	0.5	0.6	1.3	-0.8	0.2	1.1
Medication: Allopurinol	0.5	0.7	1.2	1.1	0.4	0.8
Medication: Omeprazole	0.6	0.7	1.6	-1.3	0.7	-0.2
Medication: Seretide 50 evohaler	1.1	1.3	3.8	0.2	1.9	0.3
Mean time to correctly identify matches	2.4	4.6	11.8	-0.7	-3.4	-1.3
Heart disease (mother)	0.2	0.2	0.4	-0.5	0.1	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.5	-0.7	1.6	1.1
Whole body fat mass	0.4	1.6	3.3	-0.9	0.7	-1.8
Leg fat mass (right)	0.3	1.2	2.3	-1.2	0.1	-1.5
Arm predicted mass (right)	0.3	1.5	3.4	-1.0	0.3	-1.9
Pulse rate, automated reading	0.9	2.9	7.6	-2.8	0.6	-0.8
Alcohol intake frequency.	0.5	1.1	2.6	0.2	0.9	-1.6
Comparative height size at age 10	0.6	3.2	5.4	1.4	2.3	-1.6
Number of full sisters	0.7	0.9	1.7	-1.3	-1.0	0.3
Suffer from ‘nerves’	0.1	0.1	0.2	0.3	0.3	0.4
Overall health rating	1.2	2.5	3.3	-1.8	1.3	-1.6
Chest pain or discomfort	1.1	1.5	4.1	-2.0	-0.7	-0.1
Had major operations	0.8	1.0	1.8	-1.3	-0.1	-1.1
Age at last live birth	0.9	1.4	2.4	-1.3	1.6	0.2
Family relationship satisfaction	0.4	0.5	1.0	-0.6	-1.0	0.1
Leg pain on walking	0.2	0.2	0.3	0.5	0.6	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	0.7	0.3	0.4
Commuting to job workplace: Car/motor vehicle	3.4	3.9	11.2	0.4	-3.3	0.6
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	0.3	-0.0	-0.1
Medication: Aspirin	0.2	0.2	0.3	-0.5	0.4	-0.4
Supplements: Vitamin C	0.6	0.7	1.6	-1.2	-0.5	-0.6
Knee pain experienced in last month	1.3	2.0	5.0	-2.2	-0.8	-0.6
Hypertension (Self-reported)	0.8	2.3	5.9	-1.0	-0.3	-2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	-0.3	0.1	-0.3
Illnesses of father: Heart disease	0.4	0.5	0.8	-0.9	0.0	-0.9
Illnesses of siblings: Diabetes	0.7	0.9	1.9	-0.3	0.8	-1.4
Smoking status: Previous	0.1	0.2	0.4	0.6	0.4	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.3	0.6	0.4	-0.3
Whole body fat-free mass	0.3	1.5	3.9	-0.8	0.2	-2.0
Leg fat-free mass (right)	0.4	2.3	6.1	-0.9	0.1	-2.5
Arm fat percentage (left)	0.2	0.9	2.0	-0.7	0.4	-1.4
Average weekly red wine intake	0.2	0.3	0.4	-0.3	0.5	-0.6
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	-0.2	0.0	0.8
Mood swings	0.1	0.1	0.3	0.2	-0.6	0.2
Loneliness, isolation	1.5	2.1	3.0	-1.5	-1.7	-1.1
Long-standing illness, disability or infirmity	1.0	1.5	3.5	-1.9	0.8	-0.5
Ever had bowel cancer screening	0.8	0.9	1.5	-0.5	1.2	1.0
Diabetes diagnosed by doctor	2.1	3.4	7.4	-2.7	-0.1	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.6	-0.7	0.3	-1.2
Friendships satisfaction	0.7	0.8	1.1	-0.8	-1.0	0.9
Qualifications: nursing, teaching	1.1	1.7	3.0	-1.7	0.7	-1.2
Commuting to job workplace: Walk	1.2	1.3	3.8	-0.1	2.0	0.3
Eye problems/disorders: Cataract	1.2	1.4	3.1	1.8	0.1	1.1
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.2	-0.1	0.2	-0.4
Medication for cholesterol	1.0	1.5	2.8	0.5	-1.3	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	2.9	4.7	-1.1	2.2	-1.7
Back pain experienced in last month	0.1	0.1	0.1	0.3	0.0	-0.3
Mineral and other dietary supplements	2.1	2.8	7.8	-0.4	-2.8	-0.7
Breast cancer (self-reported)	0.3	0.4	0.9	-1.0	0.1	-0.4
Asthma (self-reported)	0.1	0.2	0.4	0.6	0.3	0.2
Osteoporosis (self-reported)	1.3	1.6	4.4	0.2	2.1	-0.7
Osteoarthritis (self-reported)	1.7	2.1	6.3	0.3	-0.3	-2.5
Medication: Aspirin	0.5	0.7	1.2	-0.8	0.3	-1.1
Medication: Gliclazide	0.5	0.6	0.9	-0.8	-0.9	-0.6
Illnesses of father: None of the above (group 1)	0.6	0.7	1.3	-0.0	1.1	0.9
Smoking status: Current	0.3	0.5	0.8	0.9	-0.9	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.6	-1.3	-0.4	-1.2
Whole body water mass	0.2	1.3	3.2	-0.6	0.4	-1.8
Leg predicted mass (right)	0.4	2.3	6.1	-0.9	0.1	-2.5
Arm fat mass (left)	0.4	1.5	3.2	-1.0	0.6	-1.8
Number of self-reported non-cancer illnesses	0.7	1.2	2.5	-0.9	0.5	-1.6
Average weekly champagne plus white wine intake	0.5	0.7	1.0	-1.0	-0.6	0.9
Miserableness	0.2	0.4	0.9	-0.2	-0.9	0.4
Guilty feelings	0.2	0.3	0.5	-0.7	0.5	-0.2
Wears glasses or contact lenses	1.7	2.0	4.8	-0.2	2.2	-1.0
Ever taken oral contraceptive pill	0.2	0.2	0.4	-0.0	0.4	0.6
Hearing aid user	0.7	0.8	2.5	1.6	-0.1	-0.0
Mother’s age at death	1.8	2.2	4.8	1.3	2.2	0.2
Financial situation satisfaction	0.2	0.3	0.8	-0.9	0.1	0.3
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.1	1.1	-0.1	-0.1
Commuting to job workplace: Public transport	1.4	1.7	3.9	-0.1	2.0	-1.0
Eye problems/disorders: Glaucoma	0.7	0.9	2.6	0.2	-1.6	0.1
Medication: Blood pressure	0.5	0.9	1.9	0.5	0.7	-1.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.2	0.2	1.1	-0.1
Supplements: Fish oil (including cod liver oil)	2.1	2.8	5.4	1.7	2.3	0.2
High cholesterol (Self-reported)	0.6	1.0	2.4	-0.3	0.8	-1.6
Medication: Bendroflumethiazide	1.7	2.6	3.5	-1.0	-1.8	-1.9
Medication: Paracetamol	0.5	0.8	1.5	-1.2	-0.3	-0.8
Medication: Lisinopril	0.2	0.3	0.4	0.5	0.4	-0.6
Medication: Atorvastatin	0.5	0.6	1.0	-0.3	1.0	-0.9
Illnesses of father: High blood pressure	1.5	1.8	2.9	1.7	-1.6	0.4
Alcohol drinker status: Never	1.8	2.2	3.5	-1.7	0.3	-1.9
Ever smoked	0.0	0.0	0.1	-0.0	0.2	0.3
Basal metabolic rate	0.3	1.6	4.1	-0.9	0.4	-2.0
Leg fat percentage (left)	0.2	0.9	1.8	-1.3	-0.0	-1.0
Arm fat-free mass (left)	0.2	1.2	2.6	-0.8	0.6	-1.6
Number of operations (self-reported)	0.4	0.6	1.2	1.1	0.3	-0.8
Average weekly beer plus cider intake	0.7	1.0	2.2	0.9	0.3	1.5
Irritability	0.4	0.7	1.1	-1.1	-0.4	-0.9
Risk taking	0.2	0.2	0.6	-0.3	0.1	-0.8
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.5	0.6	1.9	0.7
Fractured/broken bones in last 5 years	0.1	0.1	0.3	0.5	-0.3	0.1
Age started oral contraceptive pill	0.4	0.5	0.8	0.9	0.9	-0.1
Diastolic blood pressure, automated reading	1.4	4.2	8.5	2.9	1.2	1.6
Ever depressed for a whole week	1.2	1.4	2.8	-1.7	-1.2	-0.5
Unable to work because of sickness or disability	1.6	2.1	4.0	-0.5	-1.4	-2.0
Commuting to job workplace: Cycle	0.5	0.6	1.8	0.2	1.4	-0.1
Myopia	1.2	1.8	4.0	-0.3	2.0	-1.1
Vascular/heart problems diagnosed by doctor	0.9	2.4	5.9	1.0	0.5	2.4
Cholesterol lowering medication	1.5	2.2	4.0	-0.1	1.6	-2.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	-0.8	0.6	0.1
Pain experienced in last month	1.1	1.8	4.5	2.1	0.0	1.0
Supplements: Calcium	1.7	1.8	3.1	-1.4	0.7	-1.8
Basal cell carcinoma (self-reported)	1.9	2.2	6.7	0.1	-0.1	-2.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	-0.4	0.9	0.5
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	3.8	0.5	0.7	1.9
Heart disease (siblings)	1.4	1.7	3.9	-0.2	2.0	-1.1
Alcohol drinker status: Previous	0.7	0.8	1.3	-0.5	-0.9	-1.2
Pack years of smoking	1.0	1.4	4.0	-0.5	-2.0	-0.4
Impedance of whole body	0.5	2.6	3.6	1.9	1.1	1.7
Leg fat mass (left)	0.5	1.9	3.5	-1.4	0.1	-1.9
Arm predicted mass (left)	0.3	1.3	2.8	-0.8	0.6	-1.7