Hub : Genes

COPS8

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.1590 0.0550 0.0027 0.001 NA 0.033 NA 0.003 0.280 NA 0.0015 NA 0.1800
2 GTEx Liver 0.3260 0.0950 0.0034 -0.009 NA -0.003 NA -0.011 0.680 NA 0.4200 NA 0.9700
3 TCGA Brain Lower Grade Glioma 0.0453 0.0353 0.0062 0.012 0.013 0.019 NA 0.017 0.015 0.012 0.0028 NA 0.0044

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.6 1.0 2.7 1.6 0.3 0.6
Bipolar Disorder or Schizophrenia 0.4 0.9 2.7 1.6 0.3 0.2
Depressed Affect (Nagel 2018) 0.1 0.2 0.6 0.0 -0.8 0.2
Depression (Nagel 2018) 0.8 1.2 1.7 -1.3 1.1 0.8
Intelligence (Savage-Jansen 2018) 0.9 2.7 4.9 -1.1 1.4 2.2
Neuroticism (Nagel 2018) 0.1 0.1 0.3 0.1 -0.6 -0.3
Schizophrenia (2018) 0.1 0.3 0.8 0.9 0.2 -0.3
Schizophrenia vs Biploar Disorder 0.2 0.2 0.6 0.3 -0.8 0.2
Worry (Nagel 2018) 0.1 0.2 0.3 0.4 -0.5 -0.5
Alzheimer’s Disease (in mother) 0.2 0.3 0.5 -0.5 0.3 0.7
Alzheimer’s Disease (in father) 0.2 0.3 0.7 0.2 -0.8 0.3
Alzheimer’s Disease (including proxy) 0.2 0.3 0.8 -0.4 0.2 0.9
Crohns Disease (2017) 1.4 3.0 7.2 -1.2 0.4 -2.7
Irritable Bowel Disease (IBD) 0.9 2.1 4.4 -1.3 0.2 -2.1
Ulcerative Colitis (UC) 0.1 0.2 0.4 -0.6 -0.1 -0.5
Major Depression (MDD) 0.6 0.8 1.6 -0.2 0.8 -1.3
Reaction Time 2.7 5.2 14.4 -0.6 -3.8 -0.9
Verbal and Numeric Reasoning (VNR) 0.7 1.6 4.9 -0.2 0.0 2.2
Breast Cancer 0.3 0.7 1.7 -0.4 0.4 1.3
Ovarian Cancer 0.4 0.5 1.2 0.5 0.4 -1.1
Prostate Cancer 0.8 1.1 3.1 -1.8 -0.5 -0.2
Age at First Birth 0.5 0.8 1.7 1.3 0.5 0.6
Bipolar Disorder (2011) 1.1 1.0 2.0 1.1 1.4 0.0
Body Mass Index (BMI) (2010) 0.2 0.3 0.7 0.2 -0.8 -0.5
Coronary Artery Disease (CAD) 0.9 1.1 1.5 -1.2 1.2 -0.5
Crohns Disease (2012) 1.4 2.3 6.1 -0.8 -0.1 -2.5
Mean Putamen Volume 0.7 0.8 1.6 1.3 -0.4 0.7
Fasting Glucose 0.1 0.1 0.3 -0.0 -0.5 0.3
HbA1C 1.0 1.1 2.4 -0.6 -1.5 -0.7
HDL Cholesterol 0.5 0.8 1.5 1.2 -0.7 0.6
LDL Cholesterol 0.5 0.8 1.2 1.1 0.0 1.1
Lupus 1.0 1.5 4.0 -0.2 2.0 -0.7
Neuroticism (2016) 1.3 1.8 4.8 0.5 2.2 0.6
Primary Biliary Cirrhosis 0.5 0.7 1.9 1.4 0.3 -0.1
Rheumatoid Arthritis 0.3 0.4 0.8 0.9 -0.5 -0.5
Schizophrenia (2014) 0.6 1.3 3.9 2.0 -0.2 -0.1
Triglycerides 0.3 0.4 0.7 0.9 -0.2 0.7
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.8 -0.0 0.3 -1.3
Ulcerative Colitis 0.3 0.5 1.3 -0.2 1.1 -0.1
Blood Eosinophil Count 0.3 2.6 3.1 -1.5 -1.8 -1.6
Blood Platelet Count 0.0 0.2 0.4 -0.3 -0.6 -0.2
Blood Red Count 0.3 3.0 5.5 0.9 -2.3 1.6
Blood White Count 0.8 5.6 14.4 0.6 -3.8 1.4
Heel T-Score 2.2 17.5 38.7 3.7 -6.2 -0.0
BMI 0.2 1.1 2.2 -0.8 0.6 -1.5
Height 0.1 1.1 2.3 1.1 1.5 0.1
Waist Hip Ratio (WHR) 1.5 6.9 15.2 -1.6 3.9 -1.7
Systolic Blood Pressure 0.0 0.2 0.3 0.6 0.0 -0.4
Smoking Status 0.4 1.0 1.9 1.4 -1.0 0.4
Allergy or Eczema 0.3 0.9 2.4 1.6 0.5 0.3
Cardiovascular Disease 1.0 3.2 4.8 -2.2 -0.1 -2.2
Hypothyroidism (self reported) 0.5 1.2 1.4 1.2 -1.0 1.1
Respiratory disease 0.2 0.4 0.5 0.7 0.7 0.6
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.7 -1.6 0.7 -0.3
Lung FEV1/FVC ratio 0.3 1.5 2.2 -1.4 -0.6 -1.5
Lung FVC 0.5 2.6 6.1 -1.0 -2.5 -0.8
Neuroticism 0.4 0.9 2.2 0.5 -1.5 -0.5
Chronotype (morning person) 0.0 0.1 0.1 -0.1 -0.1 -0.4
Hair Pigment 0.0 1.1 2.8 0.4 -1.7 0.5
Tanning 0.3 3.5 5.5 -1.5 2.3 1.7
Hand grip strength (left) 0.8 2.2 6.0 2.4 -0.5 0.7
Number of treatments/medications taken 0.0 0.0 0.1 0.1 0.3 -0.2
Average weekly spirits intake 0.4 0.5 1.3 0.2 0.3 -1.1
Sensitivity / hurt feelings 0.3 0.4 1.0 0.4 -1.0 0.3
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.7 -1.7 0.1 0.4
Hearing difficulty/problems: Yes 0.3 0.5 0.8 0.9 0.5 0.7
Relative age of first facial hair 2.1 4.3 7.7 2.8 -1.0 2.1
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 3.0 -1.7 1.0 -1.2
Ever used hormone-replacement therapy (HRT) 1.0 1.2 2.5 1.0 0.4 -1.6
Ever had hysterectomy (womb removed) 0.5 0.5 0.9 0.8 0.2 -1.0
Systolic blood pressure, automated reading 0.4 1.2 3.6 1.9 -0.0 -0.3
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.1 0.1 0.1 -0.3
Angina 1.6 2.1 5.9 0.0 -0.7 -2.4
Medication for hormone replacement therapy 0.1 0.2 0.3 -0.6 0.1 -0.4
Vitamin and mineral supplements 0.4 0.6 1.5 1.2 -0.1 0.5
Supplements: Zinc 1.3 1.4 2.3 -1.4 1.5 0.1
Medication: Co-codamol 1.2 1.4 3.0 -1.7 -0.2 -1.1
Medication: Metformin 1.4 2.0 3.8 -2.0 0.4 -1.5
Diabetes (father) 0.7 0.9 2.1 -0.5 0.5 -1.4
Diabetes (mother) 1.4 1.7 4.3 -0.9 0.3 -2.1
Severe depression (siblings) 0.3 0.4 1.0 0.3 0.0 1.0
Pack years adult smoking proportion 1.5 2.3 5.2 -0.9 -2.3 -0.9
Impedance of leg (right) 0.4 2.0 4.2 1.3 0.4 2.0
Leg fat-free mass (left) 0.4 1.9 5.2 -0.8 -0.1 -2.3
Trunk fat percentage 0.4 1.5 3.0 -0.7 0.9 -1.7
Hand grip strength (right) 0.7 1.8 4.5 2.1 0.2 0.9
Townsend deprivation index at recruitment 0.1 0.1 0.2 -0.3 -0.0 -0.5
Current tobacco smoking 0.5 0.9 1.5 1.0 -1.2 -0.2
Average weekly fortified wine intake 0.8 0.9 2.8 1.7 0.0 0.0
Maternal smoking around birth 1.3 1.9 4.0 -2.0 0.8 -1.0
Fed-up feelings 0.1 0.2 0.5 -0.1 0.4 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.3 -0.4 0.6 -0.2
Relative age voice broke 1.2 1.8 3.0 1.2 -0.9 1.7
Taking other prescription medications 0.2 0.4 1.0 0.3 1.0 -0.2
Age when periods started (menarche) 0.3 0.7 1.1 -0.8 1.1 0.6
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.5 0.0 -0.7 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.7 6.9 1.1 -2.6 0.3
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 2.0 -1.4 -0.4 -1.2
Qualifications: CSEs or equivalent 0.2 0.3 0.4 0.7 -0.5 0.5
Serious illness, injury or assault to yourself 0.4 0.5 0.8 -0.9 0.3 -0.7
High blood pressure 1.0 2.7 6.8 -0.9 -0.6 -2.6
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.4 0.6 0.2 0.6
Multivitamins +/- minerals 0.1 0.2 0.4 -0.6 -0.3 -0.2
Stomach or abdominal pain in last month 0.2 0.3 0.5 -0.7 0.2 -0.5
Supplements: Glucosamine 1.0 1.3 2.0 -0.8 1.4 1.1
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.7 -0.1 0.3 -1.3
Medication: Atenolol 1.1 1.3 1.5 -1.2 1.1 -1.1
Medication: Levothyroxine sodium 0.5 0.9 1.9 1.4 -0.7 0.5
Sitting height 0.1 0.8 1.6 1.3 0.1 -0.8
Chronic bronchitis/emphysema (father) 0.1 0.1 0.1 -0.4 -0.4 0.0
High blood pressure (mother) 0.6 0.8 1.8 0.1 -1.3 -0.8
Body mass index (BMI) 0.6 2.7 4.2 -2.0 -0.1 -2.0
Impedance of leg (left) 0.2 1.0 1.8 0.9 0.6 1.4
Leg predicted mass (left) 0.4 2.0 5.2 -0.9 -0.1 -2.3
Trunk fat mass 0.4 1.7 3.4 -0.8 1.0 -1.8
Waist circumference 1.3 4.8 7.6 -2.8 0.6 -2.5
Number of incorrect matches in round 2.3 3.8 7.7 1.8 2.8 0.8
Past tobacco smoking 0.1 0.1 0.3 -0.5 -0.1 -0.3
Alcohol usually taken with meals 0.2 0.4 0.9 0.3 -1.0 0.4
Nervous feelings 1.1 2.1 3.0 1.7 -1.1 1.4
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 1.6 0.7 -1.3 0.8
Hearing difficulty/problems with background noise 0.1 0.2 0.5 -0.7 -0.1 -0.0
Hair/balding pattern: Pattern 2 1.5 1.9 4.2 -1.1 -0.6 -2.0
Had menopause 0.1 0.1 0.2 -0.3 -0.1 -0.4
Had other major operations 0.6 0.7 1.7 0.5 -1.3 -0.2
Forced vital capacity (FVC) 0.0 0.1 0.3 -0.2 -0.2 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.4 6.4 0.9 -2.5 0.3
Ever unenthusiastic/disinterested for a whole week 2.4 2.9 5.0 -2.2 -1.0 -1.7
Qualifications: None of the above 0.1 0.3 0.6 -0.8 -0.4 0.2
Financial difficulties in last 2 years 0.8 1.1 2.9 -1.7 0.5 -0.4
Mouth/teeth dental problems 0.9 1.4 3.9 -0.5 0.3 -2.0
Heart attack 0.2 0.3 0.6 -0.3 0.7 0.5
Allergy 0.1 0.2 0.6 -0.2 -0.8 -0.3
Pain all over the body in last month 3.4 3.7 8.9 -3.0 -0.5 -1.4
Diabetes (self-reported) 1.8 2.7 6.7 -2.6 -0.0 -1.2
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.4 0.1 0.2 0.6
Medication: Ramipril 0.3 0.4 1.1 1.0 -0.3 0.4
Medication: Simvastatin 0.7 1.0 2.9 0.3 0.3 -1.7
Fluid intelligence score 0.3 0.6 1.6 -0.4 0.1 1.3
Illnesses of siblings 0.9 1.3 3.6 0.5 -0.4 1.9
Neuroticism score 0.5 1.1 3.0 -0.3 -1.7 -0.2
Weight 0.5 2.3 4.8 -1.3 0.5 -2.2
Impedance of arm (right) 0.4 1.9 4.0 2.0 0.4 1.3
Arm fat percentage (right) 0.3 1.0 2.3 -0.8 0.1 -1.5
Trunk fat-free mass 0.2 0.9 2.3 -0.6 0.2 -1.5
Hip circumference 0.4 1.6 2.9 -1.7 -0.5 -1.2
Time employed in main current job 0.2 0.3 0.5 0.5 -0.1 -0.7
Alcohol intake versus 10 years previously 1.4 2.1 5.0 1.1 2.2 -0.0
Father’s age at death 0.0 0.1 0.1 0.3 -0.2 0.1
Worrier / anxious feelings 0.2 0.3 0.5 -0.5 -0.7 -0.3
Frequency of tiredness / lethargy in last 2 weeks 2.0 3.2 8.8 -3.0 0.8 0.4
Falls in the last year 0.6 0.8 2.0 1.4 0.4 -0.4
Hair/balding pattern: Pattern 3 0.3 0.5 0.8 -0.9 -0.4 0.6
Number of live births 0.1 0.1 0.2 0.3 0.3 0.5
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 1.7 -0.9 0.0 -1.3
Pulse rate 1.7 2.9 7.5 -2.7 -0.8 -0.7
Happiness 2.5 3.1 6.0 -2.5 -1.4 -1.1
Noisy workplace 0.2 0.2 0.6 -0.0 -0.8 0.1
Qualifications: A levels/AS levels or equivalent 1.1 2.5 2.9 -1.7 1.7 -1.3
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.8 -0.9 0.4 -0.3
Mouth/teeth dental problems: Dentures 1.5 2.4 5.0 1.5 -0.0 2.2
Asthma 0.2 0.3 0.8 0.9 0.3 0.4
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.6 -0.4 0.4 0.8
Medication: Cholesterol lowering 0.5 0.8 1.4 -1.0 0.0 -1.2
Depression (self-reported) 1.8 2.2 6.2 -2.5 -0.1 0.6
Medication: Lansoprazole 0.4 0.4 0.6 -0.7 -0.5 -0.8
Prospective memory result 1.3 1.6 4.6 -0.2 -2.1 -0.5
Lung cancer (father) 0.4 0.5 0.6 0.5 -0.8 0.7
Illnesses of mother 0.5 0.6 0.8 0.8 0.6 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 3.9 -1.2 0.1 -2.0
Pulse wave Arterial Stiffness index 4.0 4.7 11.2 -0.8 -3.3 -1.4
Impedance of arm (left) 0.5 2.2 4.0 2.0 1.0 1.3
Arm fat mass (right) 0.5 2.2 4.5 -1.4 0.6 -2.1
Trunk predicted mass 0.1 0.8 2.2 -0.5 0.2 -1.5
Standing height 0.2 1.6 3.0 1.7 1.3 -0.4
Length of working week for main job 0.5 0.5 1.3 -1.1 0.2 -0.5
Exposure to tobacco smoke at home 0.9 1.0 1.8 -0.7 -0.9 -1.4
Breastfed as a baby 0.3 0.3 0.5 -0.2 0.7 0.7
Tense / ‘highly strung’ 0.4 0.6 1.8 -0.2 0.1 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.3 3.1 -1.1 -1.8 -1.6
Hair/balding pattern: Pattern 4 0.6 1.4 2.6 1.2 0.4 1.6
Birth weight of first child 1.4 2.5 5.3 -2.3 1.0 -1.1
Peak expiratory flow (PEF) 0.6 1.4 2.4 -0.6 1.6 -1.2
Pulse wave reflection index 0.5 0.6 1.0 -0.1 -0.9 -1.0
Ever highly irritable/argumentative for 2 days 1.8 2.2 4.6 -0.9 -2.1 -1.0
Loud music exposure frequency 1.8 2.0 5.6 -2.4 -0.6 -0.2
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.5 -0.7 0.2 -0.4
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.5 -0.0 -0.2 1.2
Blood clot in the leg (DVT) 0.7 0.9 2.3 0.2 0.5 1.5
Medication: Paracetamol 1.3 2.1 3.5 -1.9 -0.4 -1.6
Headache pain in last month 0.2 0.3 0.8 0.9 -0.4 0.2
Medication for cholesterol, blood pressure or diabetes 0.8 1.4 1.8 1.3 1.1 1.0
Glaucoma (self-reported) 0.9 1.1 2.6 0.1 -1.6 -0.8
Gout (self-reported) 0.2 0.3 0.6 0.1 -0.8 -0.4
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 1.8 1.4 -0.8 1.2
Medication: Amlodipine 1.1 1.5 3.7 -0.4 -0.9 -1.9
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.4 1.2 0.6 0.8
Birth weight 0.1 0.3 0.5 0.5 -0.1 0.7
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.8 -0.5 1.3 0.4
High blood pressure (siblings) 2.6 3.7 7.0 -2.0 -0.6 -2.6
Forced vital capacity (FVC), Best measure 0.2 0.8 2.0 -0.5 -0.3 -1.4
Body fat percentage 0.2 1.0 1.8 -0.8 0.6 -1.4
Leg fat percentage (right) 0.1 0.5 1.3 -1.1 -0.1 -0.5
Arm fat-free mass (right) 0.3 1.6 3.3 -0.9 0.8 -1.8
Exposure to tobacco smoke outside home 0.2 0.2 0.6 -0.8 0.1 0.1
Comparative body size at age 10 0.3 0.8 1.3 0.9 0.6 1.1
Number of full brothers 0.1 0.1 0.2 0.1 -0.0 0.5
Worry too long after embarrassment 0.4 0.7 1.7 -0.7 -1.3 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.0 -0.3 -1.4 -0.5
Wheeze or whistling in the chest in last year 0.4 0.6 1.1 -0.6 1.0 -0.6
Number of children fathered 0.0 0.0 0.0 -0.2 -0.1 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 0.8 0.9 0.9 0.7
Age at first live birth 1.5 2.6 5.2 -1.6 2.3 -0.4
Pulse wave peak to peak time 4.1 4.8 11.5 1.0 3.4 1.4
Health satisfaction 2.0 2.6 5.4 -2.3 0.3 -1.5
Shortness of breath walking on level ground 0.3 0.4 0.7 -0.6 0.2 -0.8
Qualifications: College or University degree 0.0 0.1 0.1 0.2 0.3 -0.3
Eye problems/disorders: None of the above 0.8 1.0 1.4 -1.2 1.0 -0.6
Mouth/teeth dental problems: Loose teeth 2.7 3.2 4.9 -0.9 -2.2 -2.0
Emphysema/chronic bronchitis 2.2 2.5 5.4 1.2 2.3 -0.7
Medication for pain relief, constipation, heartburn 0.9 1.6 3.4 1.8 -0.0 1.2
Neck or shoulder pain in last month 0.3 0.4 1.2 -0.4 0.1 -1.1
Medication: Blood pressure 1.4 2.5 3.8 -1.1 -1.9 -1.6
Angina (self-reported) 1.5 1.9 5.5 -0.1 -0.5 -2.4
Migraine (self-reported) 1.2 1.5 3.6 -0.9 -1.9 0.5
Medication: Ibuprofen 0.5 0.6 1.3 -0.8 0.2 1.1
Medication: Allopurinol 0.5 0.7 1.2 1.1 0.4 0.8
Medication: Omeprazole 0.6 0.7 1.6 -1.3 0.7 -0.2
Medication: Seretide 50 evohaler 1.1 1.3 3.8 0.2 1.9 0.3
Mean time to correctly identify matches 2.4 4.6 11.8 -0.7 -3.4 -1.3
Heart disease (mother) 0.2 0.2 0.4 -0.5 0.1 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 2.5 -0.7 1.6 1.1
Whole body fat mass 0.4 1.6 3.3 -0.9 0.7 -1.8
Leg fat mass (right) 0.3 1.2 2.3 -1.2 0.1 -1.5
Arm predicted mass (right) 0.3 1.5 3.4 -1.0 0.3 -1.9
Pulse rate, automated reading 0.9 2.9 7.6 -2.8 0.6 -0.8
Alcohol intake frequency. 0.5 1.1 2.6 0.2 0.9 -1.6
Comparative height size at age 10 0.6 3.2 5.4 1.4 2.3 -1.6
Number of full sisters 0.7 0.9 1.7 -1.3 -1.0 0.3
Suffer from ‘nerves’ 0.1 0.1 0.2 0.3 0.3 0.4
Overall health rating 1.2 2.5 3.3 -1.8 1.3 -1.6
Chest pain or discomfort 1.1 1.5 4.1 -2.0 -0.7 -0.1
Had major operations 0.8 1.0 1.8 -1.3 -0.1 -1.1
Age at last live birth 0.9 1.4 2.4 -1.3 1.6 0.2
Family relationship satisfaction 0.4 0.5 1.0 -0.6 -1.0 0.1
Leg pain on walking 0.2 0.2 0.3 0.5 0.6 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.4 0.7 0.3 0.4
Commuting to job workplace: Car/motor vehicle 3.4 3.9 11.2 0.4 -3.3 0.6
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.1 0.3 -0.0 -0.1
Medication: Aspirin 0.2 0.2 0.3 -0.5 0.4 -0.4
Supplements: Vitamin C 0.6 0.7 1.6 -1.2 -0.5 -0.6
Knee pain experienced in last month 1.3 2.0 5.0 -2.2 -0.8 -0.6
Hypertension (Self-reported) 0.8 2.3 5.9 -1.0 -0.3 -2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.1 -0.3 0.1 -0.3
Illnesses of father: Heart disease 0.4 0.5 0.8 -0.9 0.0 -0.9
Illnesses of siblings: Diabetes 0.7 0.9 1.9 -0.3 0.8 -1.4
Smoking status: Previous 0.1 0.2 0.4 0.6 0.4 0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.3 0.6 0.4 -0.3
Whole body fat-free mass 0.3 1.5 3.9 -0.8 0.2 -2.0
Leg fat-free mass (right) 0.4 2.3 6.1 -0.9 0.1 -2.5
Arm fat percentage (left) 0.2 0.9 2.0 -0.7 0.4 -1.4
Average weekly red wine intake 0.2 0.3 0.4 -0.3 0.5 -0.6
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.6 -0.2 0.0 0.8
Mood swings 0.1 0.1 0.3 0.2 -0.6 0.2
Loneliness, isolation 1.5 2.1 3.0 -1.5 -1.7 -1.1
Long-standing illness, disability or infirmity 1.0 1.5 3.5 -1.9 0.8 -0.5
Ever had bowel cancer screening 0.8 0.9 1.5 -0.5 1.2 1.0
Diabetes diagnosed by doctor 2.1 3.4 7.4 -2.7 -0.1 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.6 -0.7 0.3 -1.2
Friendships satisfaction 0.7 0.8 1.1 -0.8 -1.0 0.9
Qualifications: nursing, teaching 1.1 1.7 3.0 -1.7 0.7 -1.2
Commuting to job workplace: Walk 1.2 1.3 3.8 -0.1 2.0 0.3
Eye problems/disorders: Cataract 1.2 1.4 3.1 1.8 0.1 1.1
Mouth/teeth dental problems: Mouth ulcers 0.0 0.1 0.2 -0.1 0.2 -0.4
Medication for cholesterol 1.0 1.5 2.8 0.5 -1.3 1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.5 2.9 4.7 -1.1 2.2 -1.7
Back pain experienced in last month 0.1 0.1 0.1 0.3 0.0 -0.3
Mineral and other dietary supplements 2.1 2.8 7.8 -0.4 -2.8 -0.7
Breast cancer (self-reported) 0.3 0.4 0.9 -1.0 0.1 -0.4
Asthma (self-reported) 0.1 0.2 0.4 0.6 0.3 0.2
Osteoporosis (self-reported) 1.3 1.6 4.4 0.2 2.1 -0.7
Osteoarthritis (self-reported) 1.7 2.1 6.3 0.3 -0.3 -2.5
Medication: Aspirin 0.5 0.7 1.2 -0.8 0.3 -1.1
Medication: Gliclazide 0.5 0.6 0.9 -0.8 -0.9 -0.6
Illnesses of father: None of the above (group 1) 0.6 0.7 1.3 -0.0 1.1 0.9
Smoking status: Current 0.3 0.5 0.8 0.9 -0.9 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 1.6 -1.3 -0.4 -1.2
Whole body water mass 0.2 1.3 3.2 -0.6 0.4 -1.8
Leg predicted mass (right) 0.4 2.3 6.1 -0.9 0.1 -2.5
Arm fat mass (left) 0.4 1.5 3.2 -1.0 0.6 -1.8
Number of self-reported non-cancer illnesses 0.7 1.2 2.5 -0.9 0.5 -1.6
Average weekly champagne plus white wine intake 0.5 0.7 1.0 -1.0 -0.6 0.9
Miserableness 0.2 0.4 0.9 -0.2 -0.9 0.4
Guilty feelings 0.2 0.3 0.5 -0.7 0.5 -0.2
Wears glasses or contact lenses 1.7 2.0 4.8 -0.2 2.2 -1.0
Ever taken oral contraceptive pill 0.2 0.2 0.4 -0.0 0.4 0.6
Hearing aid user 0.7 0.8 2.5 1.6 -0.1 -0.0
Mother’s age at death 1.8 2.2 4.8 1.3 2.2 0.2
Financial situation satisfaction 0.2 0.3 0.8 -0.9 0.1 0.3
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.1 1.1 -0.1 -0.1
Commuting to job workplace: Public transport 1.4 1.7 3.9 -0.1 2.0 -1.0
Eye problems/disorders: Glaucoma 0.7 0.9 2.6 0.2 -1.6 0.1
Medication: Blood pressure 0.5 0.9 1.9 0.5 0.7 -1.4
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.2 0.2 1.1 -0.1
Supplements: Fish oil (including cod liver oil) 2.1 2.8 5.4 1.7 2.3 0.2
High cholesterol (Self-reported) 0.6 1.0 2.4 -0.3 0.8 -1.6
Medication: Bendroflumethiazide 1.7 2.6 3.5 -1.0 -1.8 -1.9
Medication: Paracetamol 0.5 0.8 1.5 -1.2 -0.3 -0.8
Medication: Lisinopril 0.2 0.3 0.4 0.5 0.4 -0.6
Medication: Atorvastatin 0.5 0.6 1.0 -0.3 1.0 -0.9
Illnesses of father: High blood pressure 1.5 1.8 2.9 1.7 -1.6 0.4
Alcohol drinker status: Never 1.8 2.2 3.5 -1.7 0.3 -1.9
Ever smoked 0.0 0.0 0.1 -0.0 0.2 0.3
Basal metabolic rate 0.3 1.6 4.1 -0.9 0.4 -2.0
Leg fat percentage (left) 0.2 0.9 1.8 -1.3 -0.0 -1.0
Arm fat-free mass (left) 0.2 1.2 2.6 -0.8 0.6 -1.6
Number of operations (self-reported) 0.4 0.6 1.2 1.1 0.3 -0.8
Average weekly beer plus cider intake 0.7 1.0 2.2 0.9 0.3 1.5
Irritability 0.4 0.7 1.1 -1.1 -0.4 -0.9
Risk taking 0.2 0.2 0.6 -0.3 0.1 -0.8
Ever had prostate specific antigen (PSA) test 1.3 1.5 3.5 0.6 1.9 0.7
Fractured/broken bones in last 5 years 0.1 0.1 0.3 0.5 -0.3 0.1
Age started oral contraceptive pill 0.4 0.5 0.8 0.9 0.9 -0.1
Diastolic blood pressure, automated reading 1.4 4.2 8.5 2.9 1.2 1.6
Ever depressed for a whole week 1.2 1.4 2.8 -1.7 -1.2 -0.5
Unable to work because of sickness or disability 1.6 2.1 4.0 -0.5 -1.4 -2.0
Commuting to job workplace: Cycle 0.5 0.6 1.8 0.2 1.4 -0.1
Myopia 1.2 1.8 4.0 -0.3 2.0 -1.1
Vascular/heart problems diagnosed by doctor 0.9 2.4 5.9 1.0 0.5 2.4
Cholesterol lowering medication 1.5 2.2 4.0 -0.1 1.6 -2.0
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.7 -0.8 0.6 0.1
Pain experienced in last month 1.1 1.8 4.5 2.1 0.0 1.0
Supplements: Calcium 1.7 1.8 3.1 -1.4 0.7 -1.8
Basal cell carcinoma (self-reported) 1.9 2.2 6.7 0.1 -0.1 -2.6
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.7 -0.4 0.9 0.5
Deep venous thrombosis (DVT) (self-reported) 1.2 1.5 3.8 0.5 0.7 1.9
Heart disease (siblings) 1.4 1.7 3.9 -0.2 2.0 -1.1
Alcohol drinker status: Previous 0.7 0.8 1.3 -0.5 -0.9 -1.2
Pack years of smoking 1.0 1.4 4.0 -0.5 -2.0 -0.4
Impedance of whole body 0.5 2.6 3.6 1.9 1.1 1.7
Leg fat mass (left) 0.5 1.9 3.5 -1.4 0.1 -1.9
Arm predicted mass (left) 0.3 1.3 2.8 -0.8 0.6 -1.7