Hub : Genes

ATP6V1A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Sigmoid 0.2240 0.1050 7.7e-03 -0.006 NA 0.001 NA -0.005 6.4e-01 NA 2.9e-01 NA 5.6e-01
2 GTEx Nerve Tibial 0.0987 0.0338 1.7e-05 0.089 NA 0.082 NA 0.094 7.4e-07 NA 2.0e-06 NA 3.4e-07
3 NTR Blood 0.0417 0.0115 2.2e-13 0.054 0.051 0.053 0.052 0.051 6.2e-17 4.1e-16 1.0e-16 3.2e-16 4.6e-16
4 TCGA Breast Invasive Carcinoma 0.0336 0.0317 6.2e-03 0.003 0.008 0.011 NA 0.010 7.0e-02 8.5e-03 1.8e-03 NA 3.0e-03
5 TCGA Head and Neck Squamous Cell Carcinoma 0.0194 0.0170 5.3e-03 0.017 0.009 -0.001 NA 0.014 4.5e-03 3.0e-02 4.0e-01 NA 9.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.6 0.9 3.3 0.0 -1.0 1.8 -0.6 -0.1
Bipolar Disorder or Schizophrenia 0.1 0.3 1.2 0.0 0.2 -0.4 0.4 -1.1
Depressed Affect (Nagel 2018) 0.9 2.0 3.9 0.0 -0.6 1.3 -1.9 2.0
Depression (Nagel 2018) 2.5 3.8 6.9 0.0 -2.0 2.2 -1.8 2.6
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.3 0.0 0.9 -0.2 1.5 -1.0
Neuroticism (Nagel 2018) 0.4 1.0 2.0 0.0 -0.5 0.9 -1.3 1.4
Schizophrenia (2018) 0.8 1.7 4.7 0.0 1.1 -2.2 1.0 -1.3
Schizophrenia vs Biploar Disorder 0.1 0.2 0.4 0.0 -0.2 -0.4 0.7 0.4
Worry (Nagel 2018) 0.0 0.1 0.4 0.0 0.6 -0.3 -0.0 -0.1
Alzheimer’s Disease (in mother) 0.2 0.2 0.8 0.0 0.7 -0.1 0.9 0.0
Alzheimer’s Disease (in father) 0.3 0.3 0.9 0.0 0.2 -0.6 1.0 -0.1
Alzheimer’s Disease (including proxy) 0.2 0.2 0.5 0.0 -0.4 0.6 0.7 0.5
Crohns Disease (2017) 0.8 1.7 3.5 0.0 -1.2 1.5 -1.0 1.9
Irritable Bowel Disease (IBD) 1.0 2.4 5.4 0.0 -1.2 1.9 -1.2 2.3
Ulcerative Colitis (UC) 0.6 1.2 3.6 0.0 -0.4 1.2 -0.9 1.9
Major Depression (MDD) 0.3 0.3 0.8 0.0 0.9 -0.9 -0.3 0.1
Reaction Time 0.3 0.6 1.3 0.0 -0.4 0.5 -1.1 1.1
Verbal and Numeric Reasoning (VNR) 0.9 2.2 3.2 0.0 1.8 -1.6 1.8 -1.5
Breast Cancer 0.2 0.5 1.8 0.0 -0.7 0.6 -1.3 0.2
Ovarian Cancer 0.2 0.2 0.7 0.0 0.5 -0.8 0.5 -0.3
Prostate Cancer 0.2 0.2 0.6 0.0 0.3 0.2 -0.8 0.6
Age at First Birth 0.7 1.1 1.9 0.0 0.5 -1.1 1.3 -1.4
Bipolar Disorder (2011) 0.1 0.1 0.2 0.0 -0.4 -0.1 0.0 0.4
Body Mass Index (BMI) (2010) 0.5 0.7 1.6 0.0 1.1 -1.3 0.8 -0.4
Coronary Artery Disease (CAD) 0.1 0.1 0.2 0.0 0.4 -0.1 0.0 -0.5
Crohns Disease (2012) 0.4 0.6 1.3 0.0 -0.6 1.1 -1.1 0.6
Mean Putamen Volume 1.1 1.3 2.6 0.0 -1.4 1.2 -1.6 0.5
Fasting Glucose 1.2 1.4 2.7 0.0 1.4 -1.6 0.4 -1.5
HbA1C 1.5 1.6 3.5 0.0 1.9 -0.8 1.1 -1.7
HDL Cholesterol 0.4 0.6 2.7 0.0 0.6 -0.4 0.2 -1.6
LDL Cholesterol 0.1 0.1 0.2 0.0 0.4 -0.5 0.1 0.1
Lupus 0.1 0.2 0.9 0.0 -0.9 0.1 -0.4 -0.0
Neuroticism (2016) 0.0 0.0 0.0 0.0 0.2 0.0 -0.1 -0.1
Primary Biliary Cirrhosis 0.4 0.5 1.3 0.0 0.4 -1.1 0.7 -0.7
Rheumatoid Arthritis 0.9 1.2 2.8 0.0 1.3 -0.6 1.0 -1.7
Schizophrenia (2014) 0.4 1.0 2.2 0.0 1.0 -1.5 0.3 -1.2
Triglycerides 0.3 0.5 1.5 0.0 -0.2 -0.1 0.9 1.2
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 0.0 -0.2 -0.4 0.0 0.3
Ulcerative Colitis 1.1 1.6 2.9 0.0 -1.0 1.7 -1.2 1.5
Blood Eosinophil Count 0.2 1.4 3.2 0.0 -1.4 1.8 -0.7 1.2
Blood Platelet Count 0.1 1.6 4.8 0.0 1.5 -2.2 -0.2 -1.1
Blood Red Count 0.3 2.6 7.3 0.0 -2.7 1.9 -1.0 1.0
Blood White Count 0.0 0.1 0.5 0.0 0.7 -0.3 0.4 -0.0
Heel T-Score 3.1 24.7 42.2 0.0 6.1 -6.5 4.0 -5.3
BMI 0.1 0.4 0.7 0.0 -0.8 0.8 0.2 0.8
Height 0.0 0.4 1.5 0.0 -0.3 0.3 -1.2 0.4
Waist Hip Ratio (WHR) 0.0 0.2 0.9 0.0 0.1 -0.2 0.9 0.0
Systolic Blood Pressure 1.8 9.2 13.5 0.0 3.2 -3.7 3.6 -3.0
Smoking Status 0.9 2.2 4.5 0.0 -1.4 1.7 -1.3 2.1
Allergy or Eczema 0.2 0.6 1.2 0.0 0.1 -0.9 1.0 -1.1
Cardiovascular Disease 2.0 6.6 11.0 0.0 3.2 -3.3 2.6 -2.3
Hypothyroidism (self reported) 0.6 1.3 3.0 0.0 0.7 -1.3 1.7 -1.1
Respiratory disease 0.5 1.1 2.2 0.0 -0.5 1.4 -1.5 1.1
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.6 0.0 0.8 -0.7 0.3 0.4
Lung FEV1/FVC ratio 0.2 0.9 2.2 0.0 -0.8 -0.2 -1.3 1.5
Lung FVC 0.2 0.9 2.6 0.0 -1.0 -0.1 -1.6 0.9
Neuroticism 0.1 0.2 0.3 0.0 0.2 0.4 -0.5 0.5
Chronotype (morning person) 0.7 1.7 3.6 0.0 1.3 -1.9 0.7 -1.6
Hair Pigment 0.0 0.2 0.5 0.0 -0.1 -0.7 -0.5 0.3
Tanning 0.0 0.4 1.1 0.0 -0.8 0.4 -1.0 0.2
Hand grip strength (left) 0.4 1.0 1.9 0.0 -1.4 1.4 -0.1 1.1
Number of treatments/medications taken 0.1 0.2 0.9 0.0 0.2 -0.1 -0.0 -0.9
Average weekly spirits intake 0.7 0.8 3.1 0.0 -0.2 0.1 -1.8 1.0
Sensitivity / hurt feelings 1.9 3.2 5.8 0.0 -1.8 2.0 -1.8 2.4
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.9 0.0 0.1 -0.3 -0.7 1.0
Hearing difficulty/problems: Yes 0.9 1.4 2.5 0.0 -1.3 0.7 -1.5 1.6
Relative age of first facial hair 0.8 1.6 3.3 0.0 1.8 -1.7 0.5 -1.3
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.8 0.0 -1.0 -0.7 -0.4 1.3
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.3 0.0 0.6 -0.5 0.2 -0.5
Ever had hysterectomy (womb removed) 0.2 0.2 0.5 0.0 0.7 -0.6 -0.6 0.1
Systolic blood pressure, automated reading 2.7 7.8 13.4 0.0 2.9 -3.5 3.7 -2.1
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.5 0.0 0.5 -0.7 0.3 -0.6
Angina 0.4 0.5 0.9 0.0 0.4 -0.7 1.0 -0.9
Medication for hormone replacement therapy 0.1 0.2 0.4 0.0 0.4 0.4 -0.6 -0.3
Vitamin and mineral supplements 1.3 1.8 5.7 0.0 1.2 -0.9 2.4 -1.0
Supplements: Zinc 0.0 0.0 0.1 0.0 0.3 -0.2 -0.2 0.2
Medication: Co-codamol 0.1 0.1 0.4 0.0 0.2 -0.1 0.3 -0.6
Medication: Metformin 0.2 0.3 1.0 0.0 -0.7 0.5 -0.0 1.0
Diabetes (father) 4.0 4.9 7.6 0.0 -2.8 2.6 -2.2 2.3
Diabetes (mother) 1.3 1.6 4.1 0.0 -2.0 1.4 -1.2 0.8
Severe depression (siblings) 0.6 0.6 1.8 0.0 -0.8 0.7 0.5 1.3
Pack years adult smoking proportion 0.8 1.2 3.2 0.0 -1.0 1.4 0.0 1.8
Impedance of leg (right) 2.6 12.8 22.6 0.0 4.8 -4.4 1.5 -4.4
Leg fat-free mass (left) 1.1 6.0 9.8 0.0 -3.1 3.0 -1.4 3.0
Trunk fat percentage 0.2 1.0 2.4 0.0 1.2 -1.5 1.0 -0.2
Hand grip strength (right) 0.0 0.1 0.5 0.0 -0.1 0.4 0.7 0.0
Townsend deprivation index at recruitment 0.4 0.5 2.1 0.0 0.1 -0.2 1.5 0.7
Current tobacco smoking 2.9 4.8 10.4 0.0 -2.0 2.4 -1.9 3.2
Average weekly fortified wine intake 0.4 0.5 1.0 0.0 1.0 -0.9 0.5 -0.4
Maternal smoking around birth 0.2 0.2 0.6 0.0 0.8 -0.7 -0.3 -0.2
Fed-up feelings 0.1 0.2 0.5 0.0 -0.0 0.7 -0.7 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.9 4.2 0.0 -1.2 1.6 -1.1 2.1
Relative age voice broke 1.0 1.6 2.7 0.0 1.5 -0.9 1.6 -1.5
Taking other prescription medications 0.2 0.3 0.8 0.0 -0.7 0.2 -0.9 -0.0
Age when periods started (menarche) 0.3 0.6 2.5 0.0 0.7 -0.3 1.6 -0.3
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.5 0.0 0.6 -0.7 -0.2 0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.1 5.2 0.0 2.3 -2.1 1.2 -2.1
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 1.3 0.0 -1.2 0.9 0.2 1.0
Qualifications: CSEs or equivalent 0.1 0.1 0.2 0.0 0.3 0.4 0.4 -0.0
Serious illness, injury or assault to yourself 0.2 0.2 0.6 0.0 -0.3 0.1 -0.8 0.7
High blood pressure 1.8 5.1 8.8 0.0 2.5 -3.0 2.5 -2.1
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.7 0.0 -0.5 -0.3 0.4 -0.8
Multivitamins +/- minerals 0.8 1.1 3.4 0.0 -1.0 0.9 -1.8 0.4
Stomach or abdominal pain in last month 0.4 0.5 1.6 0.0 -0.6 0.3 0.4 1.3
Supplements: Glucosamine 1.9 2.4 6.4 0.0 1.7 -1.5 0.7 -2.5
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 1.0 0.0 0.4 -1.0 0.2 0.0
Medication: Atenolol 0.5 0.6 2.5 0.0 0.2 -0.6 1.6 0.1
Medication: Levothyroxine sodium 2.2 3.8 7.7 0.0 1.8 -2.8 2.4 -1.5
Sitting height 0.1 1.0 2.3 0.0 -1.1 1.5 -0.7 1.0
Chronic bronchitis/emphysema (father) 0.1 0.2 0.4 0.0 0.4 -0.6 0.5 0.1
High blood pressure (mother) 0.6 0.8 1.8 0.0 1.1 -1.3 0.3 -1.1
Body mass index (BMI) 0.2 0.9 3.3 0.0 -1.0 0.6 0.2 1.8
Impedance of leg (left) 1.9 9.3 17.3 0.0 4.2 -3.7 1.3 -3.7
Leg predicted mass (left) 1.1 5.8 9.4 0.0 -3.1 3.0 -1.4 3.0
Trunk fat mass 0.1 0.3 0.4 0.0 0.4 -0.7 0.6 0.6
Waist circumference 0.1 0.3 0.9 0.0 0.0 -0.2 0.9 0.9
Number of incorrect matches in round 2.8 4.7 10.2 0.0 -3.2 3.2 -1.0 1.5
Past tobacco smoking 0.3 0.5 1.5 0.0 -0.9 1.2 -0.2 -0.1
Alcohol usually taken with meals 0.2 0.3 0.9 0.0 -0.9 0.1 0.5 -0.4
Nervous feelings 0.2 0.3 0.9 0.0 0.4 -0.5 0.9 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 1.7 0.0 -1.2 1.1 -0.7 1.3
Hearing difficulty/problems with background noise 0.9 1.5 2.3 0.0 -1.4 1.5 -1.0 1.4
Hair/balding pattern: Pattern 2 1.0 1.3 5.9 0.0 -0.3 0.5 -0.5 2.4
Had menopause 0.2 0.3 0.6 0.0 0.6 -0.6 0.1 0.8
Had other major operations 0.7 0.9 2.3 0.0 -0.4 0.7 -1.5 1.2
Forced vital capacity (FVC) 0.1 0.5 0.9 0.0 -0.9 0.8 -0.9 0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 3.7 0.0 1.7 -1.9 0.4 -1.8
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 1.7 0.0 0.4 0.4 -0.5 1.3
Qualifications: None of the above 0.0 0.1 0.3 0.0 -0.3 0.3 0.6 0.2
Financial difficulties in last 2 years 0.1 0.2 0.7 0.0 0.8 -0.2 0.1 -0.1
Mouth/teeth dental problems 0.9 1.4 4.3 0.0 2.1 -1.3 -0.2 -1.1
Heart attack 1.3 1.6 2.4 0.0 -1.4 1.3 -1.5 1.4
Allergy 0.1 0.1 0.4 0.0 0.6 -0.2 -0.4 0.4
Pain all over the body in last month 0.6 0.6 1.4 0.0 -1.1 0.7 -0.1 1.2
Diabetes (self-reported) 0.1 0.1 0.5 0.0 0.1 -0.1 -0.1 0.7
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 3.4 0.0 -1.8 1.1 -0.8 1.6
Medication: Ramipril 3.1 3.9 6.7 0.0 2.5 -2.0 2.6 -1.7
Medication: Simvastatin 0.7 1.0 2.4 0.0 1.5 -1.5 0.6 -0.4
Fluid intelligence score 0.5 1.0 1.6 0.0 1.2 -0.7 1.3 -1.3
Illnesses of siblings 0.0 0.1 0.3 0.0 0.2 -0.0 0.0 -0.5
Neuroticism score 0.1 0.2 0.7 0.0 -0.2 0.8 -0.4 0.5
Weight 0.2 1.1 3.2 0.0 -1.1 1.0 -0.3 1.8
Impedance of arm (right) 2.1 10.0 19.0 0.0 3.5 -4.0 1.7 -4.4
Arm fat percentage (right) 0.3 1.1 2.8 0.0 1.0 -1.7 1.3 -0.3
Trunk fat-free mass 0.7 4.1 7.3 0.0 -2.4 2.7 -1.3 2.4
Hip circumference 0.1 0.5 1.7 0.0 -0.8 0.6 -0.3 1.3
Time employed in main current job 0.1 0.1 0.4 0.0 -0.7 0.1 -0.5 -0.1
Alcohol intake versus 10 years previously 0.1 0.1 0.3 0.0 -0.1 0.3 -0.3 0.5
Father’s age at death 0.3 0.4 1.1 0.0 -0.0 -0.1 -0.9 1.0
Worrier / anxious feelings 0.1 0.3 0.5 0.0 0.4 -0.4 0.7 -0.7
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.4 0.0 -0.5 0.8 -1.2 1.2
Falls in the last year 0.7 0.9 2.6 0.0 1.1 -1.6 1.0 0.0
Hair/balding pattern: Pattern 3 0.7 1.0 2.8 0.0 0.4 -1.4 0.1 -1.7
Number of live births 0.5 0.6 1.8 0.0 0.0 -0.1 -1.3 -1.2
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 1.8 0.0 -1.2 0.7 -1.3 0.7
Pulse rate 0.4 0.7 2.3 0.0 -1.5 0.8 -0.0 0.6
Happiness 0.1 0.2 0.4 0.0 0.2 0.3 -0.4 0.7
Noisy workplace 0.1 0.1 0.3 0.0 -0.4 0.2 -0.3 -0.5
Qualifications: A levels/AS levels or equivalent 0.7 1.7 3.5 0.0 1.3 -1.9 1.3 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 0.0 -0.4 0.7 0.3 0.5
Mouth/teeth dental problems: Dentures 0.4 0.7 2.4 0.0 -0.4 0.5 1.5 0.7
Asthma 0.0 0.1 0.2 0.0 0.5 -0.1 0.3 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.9 0.0 0.1 0.3 -0.5 -0.9
Medication: Cholesterol lowering 0.3 0.5 0.9 0.0 0.8 -0.4 1.0 -0.9
Depression (self-reported) 0.6 0.7 1.6 0.0 -0.8 1.3 -0.6 1.0
Medication: Lansoprazole 0.5 0.6 1.2 0.0 -1.1 0.6 1.1 0.4
Prospective memory result 0.8 0.9 3.5 0.0 -0.1 -0.2 1.9 -1.1
Lung cancer (father) 0.2 0.3 0.7 0.0 -0.6 0.9 -0.6 0.0
Illnesses of mother 0.8 0.9 2.4 0.0 -1.3 1.6 -0.3 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 1.2 0.0 -0.9 0.6 -1.1 0.5
Pulse wave Arterial Stiffness index 0.2 0.3 0.9 0.0 0.3 -0.6 1.0 -0.3
Impedance of arm (left) 1.5 6.8 14.1 0.0 3.0 -3.1 1.0 -3.8
Arm fat mass (right) 0.1 0.3 0.8 0.0 -0.2 -0.4 0.5 0.9
Trunk predicted mass 0.7 4.1 7.5 0.0 -2.4 2.7 -1.3 2.4
Standing height 0.1 0.6 1.4 0.0 -0.6 1.2 -1.0 0.1
Length of working week for main job 0.7 0.7 1.5 0.0 -0.8 0.5 -1.1 1.2
Exposure to tobacco smoke at home 0.3 0.3 1.1 0.0 -0.5 1.1 -0.5 0.1
Breastfed as a baby 1.2 1.5 3.6 0.0 1.9 -0.8 1.2 -1.4
Tense / ‘highly strung’ 0.4 0.7 2.2 0.0 1.5 -0.8 0.6 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 2.5 0.0 1.6 -1.4 1.0 -1.5
Hair/balding pattern: Pattern 4 1.1 2.6 4.2 0.0 -2.1 1.9 -1.6 1.6
Birth weight of first child 2.6 4.7 11.6 0.0 3.4 -2.8 -0.1 -1.9
Peak expiratory flow (PEF) 0.3 0.6 1.6 0.0 -0.9 0.7 -1.3 0.4
Pulse wave reflection index 1.8 2.2 3.7 0.0 1.4 -1.7 1.9 -1.6
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.6 0.0 -0.2 -0.0 -0.1 0.8
Loud music exposure frequency 0.9 1.0 2.2 0.0 -1.2 0.7 -0.9 1.5
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.6 0.0 0.6 -0.7 0.8 -0.1
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 3.3 0.0 0.7 -1.8 0.8 -0.8
Blood clot in the leg (DVT) 0.2 0.3 1.1 0.0 -0.7 -0.1 -0.2 1.1
Medication: Paracetamol 0.2 0.3 0.8 0.0 -0.4 0.7 0.9 -0.0
Headache pain in last month 0.2 0.3 1.0 0.0 -1.0 0.7 0.1 0.5
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.6 0.0 -0.4 0.4 -0.5 0.8
Glaucoma (self-reported) 0.4 0.5 2.2 0.0 -1.5 0.5 -0.1 0.3
Gout (self-reported) 1.1 1.6 3.8 0.0 -0.7 1.0 -1.6 1.9
Hypothyroidism/myxoedema (self-reported) 1.4 2.7 5.8 0.0 1.0 -2.1 2.4 -1.4
Medication: Amlodipine 0.3 0.5 1.1 0.0 0.4 -0.3 1.1 -1.0
Medication: Ventolin 100micrograms inhaler 1.4 1.8 4.0 0.0 1.3 -1.1 2.0 -1.5
Birth weight 0.9 1.9 5.0 0.0 2.2 -1.0 -1.0 -1.6
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.9 0.0 -0.4 0.9 -0.8 0.4
High blood pressure (siblings) 0.1 0.1 0.3 0.0 0.5 -0.3 0.3 0.0
Forced vital capacity (FVC), Best measure 0.1 0.2 0.7 0.0 -0.5 0.5 -0.8 -0.2
Body fat percentage 0.3 1.2 2.9 0.0 1.4 -1.7 1.1 -0.4
Leg fat percentage (right) 0.7 2.4 5.6 0.0 2.0 -2.4 1.4 -0.6
Arm fat-free mass (right) 1.2 6.3 11.2 0.0 -2.7 3.1 -1.9 3.3
Exposure to tobacco smoke outside home 0.4 0.5 2.0 0.0 0.1 -0.6 1.4 0.5
Comparative body size at age 10 0.3 0.7 2.1 0.0 -0.6 0.5 -1.4 1.0
Number of full brothers 0.6 0.7 2.1 0.0 0.3 -0.0 1.4 -1.3
Worry too long after embarrassment 0.3 0.5 1.2 0.0 -0.9 1.1 -0.1 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.4 0.0 0.6 0.1 0.0 0.3
Wheeze or whistling in the chest in last year 0.9 1.6 4.7 0.0 -0.9 1.6 -0.2 2.2
Number of children fathered 1.1 1.2 2.5 0.0 -1.6 0.9 -1.4 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.2 0.0 -0.7 0.3 -0.4 1.1
Age at first live birth 0.9 1.6 3.9 0.0 1.0 -1.5 1.1 -2.0
Pulse wave peak to peak time 0.3 0.3 1.2 0.0 -0.2 0.6 -1.1 0.4
Health satisfaction 0.8 1.0 1.5 0.0 1.2 -1.1 1.2 -1.0
Shortness of breath walking on level ground 1.0 1.2 2.6 0.0 -1.6 0.9 -1.2 1.1
Qualifications: College or University degree 0.2 0.8 2.4 0.0 0.5 -0.6 0.9 -1.6
Eye problems/disorders: None of the above 0.3 0.3 1.2 0.0 -0.1 1.1 0.5 0.4
Mouth/teeth dental problems: Loose teeth 0.8 0.9 1.6 0.0 -1.3 1.1 -0.6 1.2
Emphysema/chronic bronchitis 0.1 0.1 0.3 0.0 -0.3 0.5 0.6 0.3
Medication for pain relief, constipation, heartburn 0.3 0.4 1.3 0.0 0.4 -0.4 1.1 0.8
Neck or shoulder pain in last month 1.0 1.5 4.4 0.0 -2.1 1.4 -0.9 0.4
Medication: Blood pressure 0.4 0.7 1.8 0.0 0.5 -0.7 1.3 -0.9
Angina (self-reported) 0.3 0.4 0.8 0.0 0.2 -0.5 0.9 -0.9
Migraine (self-reported) 0.7 0.8 2.3 0.0 -1.5 1.0 -0.9 0.2
Medication: Ibuprofen 0.3 0.3 1.4 0.0 0.4 0.1 0.2 -1.2
Medication: Allopurinol 0.2 0.3 0.8 0.0 0.0 0.9 -0.3 0.7
Medication: Omeprazole 0.8 0.9 2.1 0.0 -0.0 -1.0 -1.5 1.2
Medication: Seretide 50 evohaler 1.2 1.4 4.4 0.0 0.9 -0.7 1.0 -2.1
Mean time to correctly identify matches 0.2 0.4 1.6 0.0 -0.2 0.1 -1.2 0.7
Heart disease (mother) 1.3 1.6 2.7 0.0 1.6 -1.6 1.3 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.4 0.0 -1.0 1.2 0.0 0.8
Whole body fat mass 0.1 0.2 0.6 0.0 0.3 -0.6 0.7 0.4
Leg fat mass (right) 0.1 0.4 0.7 0.0 0.5 -0.8 0.8 0.6
Arm predicted mass (right) 1.1 5.9 10.6 0.0 -2.6 3.1 -1.6 3.2
Pulse rate, automated reading 0.1 0.2 0.5 0.0 0.7 -0.6 0.1 0.5
Alcohol intake frequency. 0.3 0.8 2.0 0.0 -1.4 0.6 0.3 1.2
Comparative height size at age 10 0.5 2.8 5.6 0.0 -1.8 2.4 -1.4 1.8
Number of full sisters 1.4 1.7 3.6 0.0 -1.6 1.9 0.7 1.4
Suffer from ‘nerves’ 0.6 0.9 1.8 0.0 1.3 -0.9 0.6 -1.2
Overall health rating 0.3 0.7 2.3 0.0 -0.7 0.7 -0.2 1.5
Chest pain or discomfort 0.7 1.0 2.5 0.0 -0.7 0.6 -1.3 1.6
Had major operations 0.1 0.1 0.4 0.0 -0.1 0.1 -0.6 -0.2
Age at last live birth 1.4 2.0 4.1 0.0 1.3 -1.9 0.8 -2.0
Family relationship satisfaction 0.5 0.6 1.9 0.0 1.4 -1.1 -0.0 0.1
Leg pain on walking 2.6 3.2 5.9 0.0 -1.9 1.8 -2.4 1.9
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.5 0.0 -0.2 0.2 0.3 -0.7
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.9 0.0 -0.9 0.6 -0.1 0.4
Illness, injury, bereavement, stress in last 2 years 0.4 0.4 1.0 0.0 -1.0 0.4 -0.9 -0.5
Medication: Aspirin 0.5 0.6 1.4 0.0 -0.2 0.7 -1.2 -1.1
Supplements: Vitamin C 0.2 0.3 0.5 0.0 0.4 -0.6 -0.7 -0.5
Knee pain experienced in last month 0.5 0.7 2.5 0.0 -0.5 0.8 -0.5 1.6
Hypertension (Self-reported) 1.8 5.1 8.9 0.0 2.6 -3.0 2.4 -2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.9 0.0 -1.4 0.5 -0.6 0.8
Illnesses of father: Heart disease 1.0 1.4 2.5 0.0 -1.4 1.2 -1.6 1.0
Illnesses of siblings: Diabetes 0.7 0.9 2.1 0.0 -1.4 0.9 -0.9 0.8
Smoking status: Previous 0.1 0.1 0.3 0.0 0.4 -0.6 -0.2 0.2
Forced expiratory volume in 1-second (FEV1), predicted 1.4 3.0 5.6 0.0 -2.4 2.0 -1.9 1.4
Whole body fat-free mass 1.0 5.6 9.4 0.0 -2.8 3.1 -1.5 2.9
Leg fat-free mass (right) 1.5 8.1 13.2 0.0 -3.6 3.6 -1.5 3.5
Arm fat percentage (left) 0.1 0.5 1.2 0.0 0.6 -1.1 0.9 0.1
Average weekly red wine intake 0.4 0.6 1.8 0.0 0.3 -0.9 0.6 -1.3
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.3 0.0 1.1 -1.0 0.5 -0.5
Mood swings 0.8 1.5 4.4 0.0 -0.3 0.5 -2.1 1.6
Loneliness, isolation 0.2 0.3 0.7 0.0 0.3 -0.8 0.3 0.8
Long-standing illness, disability or infirmity 0.2 0.3 1.0 0.0 0.2 -0.5 0.5 1.0
Ever had bowel cancer screening 1.0 1.2 2.8 0.0 1.0 -1.7 -0.2 -1.5
Diabetes diagnosed by doctor 0.1 0.1 0.3 0.0 0.5 -0.4 0.6 0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 1.0 0.0 -1.0 0.6 -0.9 -0.3
Friendships satisfaction 0.3 0.4 1.3 0.0 1.1 -0.6 0.2 0.4
Qualifications: nursing, teaching 0.5 0.8 2.4 0.0 -0.6 0.7 -1.6 -0.8
Commuting to job workplace: Walk 0.3 0.3 0.6 0.0 0.1 0.7 -0.7 -0.6
Eye problems/disorders: Cataract 0.4 0.4 1.5 0.0 0.3 -1.2 -0.8 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.1 0.0 -1.1 -0.0 0.2 -0.4
Medication for cholesterol 2.6 4.0 8.8 0.0 -3.0 2.7 -0.9 1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.3 0.0 -0.1 -0.1 0.5 -0.6
Back pain experienced in last month 2.7 3.9 8.6 0.0 -1.7 2.0 -1.9 2.9
Mineral and other dietary supplements 0.3 0.3 1.1 0.0 -0.7 0.2 1.0 0.4
Breast cancer (self-reported) 0.5 0.6 2.0 0.0 0.8 -1.4 0.6 -0.3
Asthma (self-reported) 0.0 0.0 0.1 0.0 0.3 0.1 0.2 0.0
Osteoporosis (self-reported) 0.2 0.3 0.7 0.0 0.4 -0.8 0.7 -0.3
Osteoarthritis (self-reported) 0.2 0.2 0.8 0.0 -0.3 0.4 -0.9 0.4
Medication: Aspirin 0.3 0.3 0.8 0.0 -0.1 0.6 -0.7 -0.9
Medication: Gliclazide 0.0 0.0 0.2 0.0 0.2 0.0 0.4 0.0
Illnesses of father: None of the above (group 1) 0.1 0.1 0.3 0.0 0.6 -0.4 0.1 -0.5
Smoking status: Current 1.8 2.8 6.2 0.0 -1.6 1.8 -1.5 2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.8 3.6 0.0 1.3 -1.9 1.1 -1.7
Whole body water mass 1.0 5.8 9.5 0.0 -2.9 3.1 -1.5 3.0
Leg predicted mass (right) 1.6 8.3 13.5 0.0 -3.7 3.6 -1.6 3.6
Arm fat mass (left) 0.1 0.2 0.7 0.0 -0.2 -0.2 0.6 0.9
Number of self-reported non-cancer illnesses 0.1 0.2 0.5 0.0 -0.7 -0.4 0.4 -0.1
Average weekly champagne plus white wine intake 0.5 0.6 1.7 0.0 -1.3 0.8 -0.9 0.1
Miserableness 1.7 2.9 5.3 0.0 -1.4 1.9 -2.3 2.0
Guilty feelings 0.2 0.2 0.9 0.0 -0.1 0.1 0.9 -0.6
Wears glasses or contact lenses 1.6 1.9 3.1 0.0 -1.7 1.8 -1.3 1.2
Ever taken oral contraceptive pill 0.3 0.3 1.0 0.0 -0.2 0.5 -0.4 -1.0
Hearing aid user 0.5 0.6 2.0 0.0 0.7 -0.2 1.4 -0.6
Mother’s age at death 0.4 0.4 1.7 0.0 0.5 -0.0 -1.3 -0.5
Financial situation satisfaction 0.5 0.6 1.1 0.0 0.6 -0.7 -1.0 1.0
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.6 0.0 0.6 -0.2 0.8 0.5
Commuting to job workplace: Public transport 0.2 0.2 0.5 0.0 -0.6 0.5 0.0 0.7
Eye problems/disorders: Glaucoma 1.0 1.2 4.0 0.0 -2.0 1.0 -0.4 0.9
Medication: Blood pressure 2.2 4.2 9.9 0.0 2.9 -3.1 0.7 -1.5
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.2 0.0 -0.2 0.4 -0.1 0.4
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.7 0.0 0.5 -0.1 -0.9 0.4
High cholesterol (Self-reported) 1.3 2.3 4.2 0.0 2.0 -1.9 1.1 -1.5
Medication: Bendroflumethiazide 0.2 0.3 0.6 0.0 0.7 -0.8 0.2 -0.6
Medication: Paracetamol 0.0 0.1 0.3 0.0 -0.2 0.2 0.5 0.1
Medication: Lisinopril 0.2 0.3 0.6 0.0 0.8 -0.4 -0.4 -0.7
Medication: Atorvastatin 0.7 0.9 1.2 0.0 -1.1 1.1 -0.9 1.0
Illnesses of father: High blood pressure 0.7 0.8 2.5 0.0 0.2 -0.3 1.6 -1.2
Alcohol drinker status: Never 1.1 1.3 2.8 0.0 -1.7 1.2 -0.8 1.3
Ever smoked 0.2 0.3 1.2 0.0 0.1 -0.4 -0.2 1.1
Basal metabolic rate 0.8 4.6 7.7 0.0 -2.6 2.7 -1.2 2.8
Leg fat percentage (left) 0.5 1.7 3.8 0.0 1.6 -1.9 1.5 -0.1
Arm fat-free mass (left) 0.8 4.3 9.5 0.0 -2.2 2.5 -1.0 3.1
Number of operations (self-reported) 0.1 0.1 0.2 0.0 0.5 -0.1 -0.2 0.5
Average weekly beer plus cider intake 1.0 1.5 2.5 0.0 1.5 -1.6 1.3 0.8
Irritability 1.7 2.9 5.2 0.0 -1.8 1.4 -2.3 2.0
Risk taking 1.7 2.6 5.5 0.0 2.3 -2.3 -0.0 -1.4
Ever had prostate specific antigen (PSA) test 1.0 1.2 3.0 0.0 -1.1 1.2 -1.7 -0.4
Fractured/broken bones in last 5 years 0.5 0.7 2.9 0.0 0.4 0.4 1.7 -0.5
Age started oral contraceptive pill 0.1 0.1 0.2 0.0 -0.4 -0.2 0.4 -0.1
Diastolic blood pressure, automated reading 1.6 4.9 7.8 0.0 2.5 -2.8 2.7 -1.8
Ever depressed for a whole week 0.4 0.5 1.4 0.0 1.2 -0.7 -0.6 0.6
Unable to work because of sickness or disability 0.4 0.5 1.4 0.0 -0.4 0.8 -0.4 1.2
Commuting to job workplace: Cycle 1.1 1.3 3.2 0.0 1.0 -1.8 1.3 -0.9
Myopia 0.5 0.7 1.9 0.0 -1.1 0.7 -1.4 0.0
Vascular/heart problems diagnosed by doctor 1.9 5.1 8.5 0.0 -2.6 2.9 -2.4 2.1
Cholesterol lowering medication 1.2 1.7 4.4 0.0 1.9 -2.1 0.8 0.1
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 3.2 0.0 -0.6 -0.6 -1.8 0.8
Pain experienced in last month 0.9 1.5 3.3 0.0 1.8 -1.3 0.1 -1.6
Supplements: Calcium 2.4 2.6 5.3 0.0 2.3 -2.0 0.8 -1.8
Basal cell carcinoma (self-reported) 1.0 1.1 2.0 0.0 -1.3 1.4 -0.5 1.3
Heart attack/myocardial infarction (self-reported) 1.3 1.6 2.2 0.0 -1.5 1.5 -1.4 1.4
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.3 0.0 -0.7 0.1 -0.2 1.1
Heart disease (siblings) 0.1 0.1 0.5 0.0 -0.3 0.1 0.7 0.0
Alcohol drinker status: Previous 0.1 0.1 0.2 0.0 -0.5 -0.4 0.4 -0.4
Pack years of smoking 0.6 0.8 2.0 0.0 -0.7 1.2 0.3 1.4
Impedance of whole body 1.7 8.6 15.1 0.0 3.7 -3.6 1.1 -3.9
Leg fat mass (left) 0.1 0.4 1.0 0.0 0.2 -0.5 0.8 1.0
Arm predicted mass (left) 0.7 3.4 7.5 0.0 -1.9 2.2 -0.9 2.7