Hub : Genes

QTRTD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.049	0.022	0.0067	0.044	0.009	0.019	0.013	0.032	4.5e-06	0.0220	0.00200	0.0085	8.7e-05
2	GTEx	Stomach	0.091	0.043	0.0058	0.082	NA	0.042	NA	0.080	9.2e-05	NA	0.00450	NA	1.1e-04
3	TCGA	Colon Adenocarcinoma	0.046	0.027	0.0081	0.024	0.016	0.012	NA	0.002	1.5e-02	0.0370	0.06300	NA	2.3e-01
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.089	0.049	0.0013	0.035	0.056	0.049	NA	0.061	4.2e-03	0.0004	0.00089	NA	2.2e-04
5	TCGA	Testicular Germ Cell Tumors	0.143	0.074	0.0013	0.019	0.030	0.005	NA	-0.001	6.9e-02	0.0300	0.21000	NA	3.5e-01
6	TCGA	Thyroid Carcinoma	0.039	0.021	0.0016	0.044	0.017	0.034	NA	0.010	4.2e-05	0.0086	0.00027	NA	3.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	1.1	-0.6	-0.7	0.6	1.1	0.9	-0.0
Bipolar Disorder or Schizophrenia	0.1	0.2	0.6	-0.1	0.3	-0.1	0.8	0.7	-0.1
Depressed Affect (Nagel 2018)	0.5	1.0	2.6	-1.6	-0.8	1.2	0.9	0.8	-0.2
Depression (Nagel 2018)	0.7	1.1	4.1	-0.9	-2.0	1.0	0.5	0.4	0.1
Intelligence (Savage-Jansen 2018)	1.3	4.1	8.8	-2.0	1.1	-2.2	-1.8	-1.6	-3.0
Neuroticism (Nagel 2018)	2.0	4.6	9.0	-2.2	-0.6	3.0	2.8	2.2	0.7
Schizophrenia (2018)	0.1	0.3	1.0	0.4	1.0	-0.6	0.1	0.3	-0.1
Schizophrenia vs Biploar Disorder	0.5	0.6	2.3	1.5	-0.2	-0.2	-0.1	0.0	1.2
Worry (Nagel 2018)	2.7	5.6	10.8	-1.8	0.5	3.0	3.3	3.2	0.6
Alzheimer’s Disease (in mother)	2.7	3.2	5.2	-1.0	0.6	-2.0	-2.3	-2.0	-2.0
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.3	0.2	0.0	-0.1	-0.4	0.3
Alzheimer’s Disease (including proxy)	0.6	0.8	1.4	-1.0	-0.3	-0.7	-0.9	-1.2	-1.0
Crohns Disease (2017)	0.9	2.1	4.9	-0.9	-1.1	2.2	1.7	0.7	1.4
Irritable Bowel Disease (IBD)	0.2	0.4	0.7	-0.5	-0.8	0.8	0.9	0.5	0.1
Ulcerative Colitis (UC)	0.2	0.4	1.2	0.2	-0.2	-1.0	-0.5	-0.0	-1.1
Major Depression (MDD)	0.1	0.2	0.4	-0.5	0.6	0.4	0.3	0.0	0.1
Reaction Time	0.0	0.1	0.2	-0.3	-0.5	0.2	0.0	-0.3	0.2
Verbal and Numeric Reasoning (VNR)	3.1	7.4	12.8	-0.7	2.1	-3.6	-3.1	-2.3	-3.4
Breast Cancer	0.1	0.2	0.6	0.2	-0.8	0.5	0.5	0.1	0.4
Ovarian Cancer	0.6	0.8	4.2	2.0	0.4	-0.3	-0.2	0.3	0.5
Prostate Cancer	0.1	0.1	0.3	0.6	0.3	-0.3	-0.2	-0.0	-0.3
Age at First Birth	0.4	0.6	2.0	0.2	0.6	0.6	1.4	0.9	0.3
Bipolar Disorder (2011)	0.4	0.4	0.8	-0.9	-0.5	0.1	0.8	0.4	-0.6
Body Mass Index (BMI) (2010)	1.4	1.9	2.7	1.4	0.9	1.2	1.4	1.6	1.4
Coronary Artery Disease (CAD)	0.3	0.3	0.6	-0.8	0.1	0.5	0.2	-0.6	0.8
Crohns Disease (2012)	4.0	6.5	14.1	-1.3	-0.6	3.8	3.4	2.1	2.6
Mean Putamen Volume	1.5	1.7	3.3	-0.4	-1.2	1.5	1.8	1.6	0.8
Fasting Glucose	0.4	0.4	1.9	0.7	1.4	-0.1	-0.4	0.1	0.3
HbA1C	0.4	0.5	2.9	0.2	1.7	-0.1	-0.0	0.1	0.0
HDL Cholesterol	0.9	1.5	2.5	-1.6	0.5	-1.3	-0.9	-1.2	-1.4
LDL Cholesterol	0.3	0.4	0.8	0.7	0.3	-0.6	-0.9	-0.3	-0.8
Lupus	0.4	0.6	2.0	-1.4	-0.7	0.1	0.7	-0.7	-0.1
Neuroticism (2016)	1.2	1.7	2.6	0.8	0.5	1.6	1.5	1.5	1.5
Primary Biliary Cirrhosis	0.5	0.7	1.3	-0.9	0.3	-0.9	-0.8	-0.8	-1.1
Rheumatoid Arthritis	0.6	0.8	2.1	-1.3	1.4	0.2	-0.1	-1.0	-0.3
Schizophrenia (2014)	0.2	0.5	1.0	1.0	0.9	-1.0	0.1	0.6	-0.4
Triglycerides	0.2	0.2	0.8	0.9	-0.6	0.1	0.0	0.3	0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.3	1.3	-1.1	-0.2	-0.0	-0.2	-0.4	-0.3
Ulcerative Colitis	0.3	0.5	1.0	0.0	-1.0	-0.1	0.5	1.0	-0.8
Blood Eosinophil Count	0.2	1.5	2.7	0.2	-1.3	-1.6	-1.6	-0.7	-1.3
Blood Platelet Count	0.1	1.1	3.9	2.0	1.1	-0.5	-0.1	1.1	-0.4
Blood Red Count	0.2	2.1	5.9	0.7	-2.4	1.3	1.2	1.0	1.6
Blood White Count	0.1	0.5	1.4	-1.2	0.5	1.0	0.5	0.5	0.0
Heel T-Score	1.2	9.2	35.6	2.4	6.0	1.3	1.7	2.6	1.6
BMI	0.1	0.8	1.7	0.5	-0.6	-1.2	-1.3	-0.9	-0.7
Height	0.3	5.3	11.0	2.4	0.1	-3.0	-3.3	-2.1	-1.3
Waist Hip Ratio (WHR)	0.1	0.4	0.7	-0.8	0.2	-0.8	-0.6	-0.6	-0.8
Systolic Blood Pressure	0.6	3.2	12.4	-0.1	3.5	1.8	1.1	0.3	1.6
Smoking Status	1.1	2.7	7.2	-1.4	-1.6	-0.5	-2.0	-2.7	-0.0
Allergy or Eczema	0.2	0.5	1.3	0.7	0.3	0.7	0.8	0.4	1.1
Cardiovascular Disease	0.7	2.3	11.8	1.1	3.4	-0.8	-0.3	-0.4	0.0
Hypothyroidism (self reported)	0.5	1.2	4.8	2.2	0.6	-1.1	-0.8	-0.4	0.4
Respiratory disease	0.1	0.2	0.5	-0.6	-0.4	-0.0	0.1	0.4	-0.7
Type 2 Diabetes (T2D) (2018)	0.8	1.6	3.0	-1.2	0.8	-1.3	-1.2	-1.0	-1.7
Lung FEV1/FVC ratio	0.3	1.5	4.8	-0.3	-0.7	-1.5	-1.2	-0.1	-2.2
Lung FVC	0.4	2.1	5.5	2.3	-0.8	0.7	1.1	1.1	2.0
Neuroticism	0.4	0.9	2.1	-1.5	-0.0	1.2	0.9	1.1	-0.4
Chronotype (morning person)	0.7	1.5	4.0	-1.8	1.3	-0.4	0.1	0.2	-2.0
Hair Pigment	0.0	0.4	0.6	-0.8	0.5	0.5	0.2	-0.8	0.6
Tanning	0.0	0.5	1.6	0.8	-0.5	-0.3	0.2	1.3	-0.7
Hand grip strength (left)	0.2	0.6	1.2	0.5	-1.1	0.3	-0.5	-1.1	1.0
Number of treatments/medications taken	0.1	0.2	0.5	0.7	0.2	0.1	0.3	0.6	0.0
Average weekly spirits intake	0.3	0.3	1.0	-0.5	0.2	1.0	0.6	-0.1	0.6
Sensitivity / hurt feelings	1.4	2.4	9.4	-3.1	-1.6	0.7	-0.2	-0.5	-1.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.7	-1.3	0.1	0.9	-0.0	0.0	-0.1
Hearing difficulty/problems: Yes	1.0	1.6	2.6	1.6	-1.6	-1.3	-1.4	-0.6	-0.4
Relative age of first facial hair	1.0	2.0	6.2	-2.5	1.8	-0.1	-0.5	-0.7	-1.4
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	1.9	0.2	-1.3	0.9	1.4	1.4	0.7
Ever used hormone-replacement therapy (HRT)	2.0	2.5	6.3	1.3	0.9	-1.9	-2.5	-1.2	-1.1
Ever had hysterectomy (womb removed)	0.2	0.3	0.7	-0.4	0.5	0.0	0.3	0.6	-0.8
Systolic blood pressure, automated reading	1.0	2.9	9.3	0.5	3.1	1.6	1.3	0.7	1.8
Eye problems/disorders: Diabetes related eye disease	2.8	3.1	7.5	-2.2	0.4	-1.8	-1.3	-1.2	-2.7
Angina	0.1	0.2	0.3	-0.5	0.2	0.3	0.5	-0.1	0.5
Medication for hormone replacement therapy	0.6	0.6	2.3	1.5	0.5	-0.4	-1.0	0.0	0.3
Vitamin and mineral supplements	1.5	2.1	5.4	-2.3	1.0	-0.7	-1.0	-1.4	-1.7
Supplements: Zinc	0.7	0.7	1.7	0.3	0.2	-1.2	-1.0	-1.3	-0.5
Medication: Co-codamol	0.5	0.6	2.2	0.7	0.1	0.2	0.8	1.5	-0.1
Medication: Metformin	1.1	1.5	3.8	0.1	-0.6	-1.5	-1.4	-0.7	-1.9
Diabetes (father)	2.3	2.9	6.8	-2.6	-2.5	-0.6	-0.4	-0.7	-1.8
Diabetes (mother)	0.8	1.1	2.6	-0.7	-1.6	-1.0	-0.8	-0.6	-1.2
Severe depression (siblings)	1.7	1.9	4.0	1.6	-0.7	-1.8	-2.0	-0.7	-1.0
Pack years adult smoking proportion	1.3	1.9	3.1	-1.1	-0.8	-1.4	-1.8	-1.6	-1.3
Impedance of leg (right)	1.0	4.7	22.6	-0.9	4.8	1.3	1.4	0.9	0.5
Leg fat-free mass (left)	0.4	2.1	8.9	-0.3	-3.0	-0.5	-1.1	-1.4	-0.1
Trunk fat percentage	0.3	1.2	2.1	-1.1	1.1	1.4	1.4	0.6	0.5
Hand grip strength (right)	0.2	0.7	2.3	-0.1	0.1	-0.7	-1.1	-1.5	-0.1
Townsend deprivation index at recruitment	0.1	0.1	0.4	0.3	-0.0	0.1	-0.3	-0.4	0.6
Current tobacco smoking	1.1	1.7	4.5	-2.0	-2.1	0.2	-0.5	-1.2	-0.3
Average weekly fortified wine intake	0.7	0.8	1.7	0.7	1.2	-1.3	-0.5	-0.7	-0.8
Maternal smoking around birth	2.3	3.3	6.7	1.3	0.9	-2.5	-2.6	-1.8	-1.0
Fed-up feelings	0.5	0.9	4.0	-2.0	-0.1	0.1	-0.5	-0.3	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.1	-0.5	-1.1	0.5	-0.3	0.2	0.0
Relative age voice broke	0.5	0.7	2.7	-1.2	1.6	0.2	-0.0	-0.0	-0.3
Taking other prescription medications	0.6	1.0	1.9	-0.4	-0.9	1.2	1.4	1.2	0.5
Age when periods started (menarche)	3.0	7.2	12.4	-2.2	1.1	-2.9	-2.8	-2.8	-3.5
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.2	-0.1	0.2	0.1	-0.4	-0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	5.1	0.5	2.2	-0.2	-0.3	-0.8	0.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.0	0.7	-0.8	0.7	0.4	-0.2	1.4
Qualifications: CSEs or equivalent	1.4	1.8	3.7	-0.5	0.4	1.9	1.9	0.7	1.7
Serious illness, injury or assault to yourself	1.4	1.7	5.9	-1.0	-0.8	-1.4	-0.7	0.4	-2.4
High blood pressure	0.5	1.5	5.9	0.5	2.4	-1.1	-0.4	0.1	-1.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.5	0.1	-0.1	1.1	1.0	0.3	1.2
Multivitamins +/- minerals	0.9	1.1	3.4	1.8	-0.9	0.4	0.7	1.0	1.0
Stomach or abdominal pain in last month	0.4	0.6	1.3	0.8	-1.0	0.2	0.6	1.1	-0.0
Supplements: Glucosamine	1.6	2.0	4.7	1.4	2.2	-1.8	-1.4	-0.7	-0.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.8	1.3	0.1	0.4	0.7	1.1	0.9
Medication: Atenolol	0.0	0.0	0.1	0.3	0.0	-0.1	0.3	-0.1	0.3
Medication: Levothyroxine sodium	0.6	1.1	3.0	1.4	1.7	-0.0	0.5	0.2	1.1
Sitting height	0.6	4.1	8.0	-2.0	-1.0	-1.7	-2.3	-2.8	-1.9
Chronic bronchitis/emphysema (father)	0.8	0.9	1.8	0.3	0.3	1.1	1.4	1.2	1.0
High blood pressure (mother)	1.7	2.4	5.2	-1.4	1.5	1.5	2.3	1.5	0.2
Body mass index (BMI)	0.0	0.2	0.7	0.2	-0.8	0.2	0.4	0.2	0.3
Impedance of leg (left)	0.7	3.2	16.2	-0.8	4.0	0.9	1.1	0.7	-0.1
Leg predicted mass (left)	0.4	2.0	8.7	-0.2	-3.0	-0.5	-1.1	-1.3	-0.1
Trunk fat mass	0.1	0.4	0.8	-0.7	0.3	0.9	0.9	0.3	0.4
Waist circumference	0.0	0.1	0.2	-0.1	0.1	0.4	0.3	0.1	0.4
Number of incorrect matches in round	1.0	1.7	9.2	-0.6	-3.0	-0.6	-0.2	-0.2	-0.6
Past tobacco smoking	1.3	2.4	5.3	0.9	-0.7	1.2	2.2	2.3	1.1
Alcohol usually taken with meals	0.1	0.1	0.6	0.2	-0.7	-0.1	-0.0	-0.3	-0.0
Nervous feelings	3.1	5.7	11.5	-0.7	0.5	3.2	3.4	3.3	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	4.4	0.3	-1.4	0.9	0.9	2.1	0.2
Hearing difficulty/problems with background noise	1.5	2.3	3.5	0.3	-1.7	-1.9	-1.9	-0.8	-1.8
Hair/balding pattern: Pattern 2	3.6	4.6	9.8	0.3	-0.6	-3.1	-2.9	-1.8	-2.5
Had menopause	0.1	0.2	0.3	0.4	0.6	-0.4	-0.3	0.5	-0.3
Had other major operations	0.1	0.1	0.3	-0.2	-0.1	0.1	-0.1	0.4	-0.6
Forced vital capacity (FVC)	0.1	0.3	1.0	1.0	-0.7	-0.1	0.1	0.2	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	2.4	-0.0	1.6	-0.3	-0.2	-0.8	0.3
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	3.2	-1.8	0.4	-0.1	-1.5	-1.6	-0.9
Qualifications: None of the above	0.3	0.6	2.2	0.3	-0.4	-0.0	0.3	1.5	-0.9
Financial difficulties in last 2 years	0.5	0.6	1.4	-0.9	0.6	0.3	0.7	1.2	-0.8
Mouth/teeth dental problems	1.3	1.9	3.6	0.0	1.9	-1.5	-1.5	-1.3	-1.3
Heart attack	0.6	0.7	2.5	0.3	-1.6	-0.9	-0.7	-0.2	-0.8
Allergy	0.1	0.2	0.5	0.7	0.4	-0.5	-0.2	0.3	0.0
Pain all over the body in last month	0.5	0.5	1.6	-0.3	-1.2	-0.7	-0.5	-0.1	-0.8
Diabetes (self-reported)	1.2	1.9	4.8	-0.3	0.4	-1.9	-1.4	-0.9	-2.2
Hayfever/allergic rhinitis (self-reported)	2.2	3.0	6.2	0.1	-1.8	2.5	1.6	0.5	2.3
Medication: Ramipril	1.3	1.7	6.0	-0.6	2.5	-0.6	-1.1	-1.1	-0.9
Medication: Simvastatin	0.7	1.1	2.8	1.7	1.4	0.2	0.3	0.3	1.2
Fluid intelligence score	2.6	5.5	13.9	-0.7	1.2	-3.1	-2.3	-1.5	-3.7
Illnesses of siblings	0.4	0.5	1.6	1.2	0.1	0.2	0.4	0.8	0.9
Neuroticism score	0.3	0.7	2.0	-1.4	-0.3	0.8	0.4	0.8	-0.8
Weight	0.1	0.3	0.9	-0.4	-0.9	-0.3	-0.4	-0.8	-0.2
Impedance of arm (right)	0.8	3.6	10.5	-2.3	3.2	1.6	1.6	0.4	0.5
Arm fat percentage (right)	0.2	0.7	1.3	-0.8	0.9	0.9	1.1	0.6	0.4
Trunk fat-free mass	0.3	1.9	5.1	0.4	-2.2	-1.2	-1.6	-1.3	-0.6
Hip circumference	0.1	0.5	1.5	-0.5	-0.7	1.2	0.6	0.1	0.8
Time employed in main current job	0.7	0.8	2.6	0.1	-0.4	-0.8	-1.2	-1.6	-0.2
Alcohol intake versus 10 years previously	0.8	1.2	2.9	0.8	0.4	-1.7	-1.5	-0.3	-1.3
Father’s age at death	0.2	0.2	0.6	-0.5	-0.3	0.3	-0.6	-0.8	0.2
Worrier / anxious feelings	0.6	1.1	3.1	-1.8	0.2	1.0	1.1	0.9	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.1	5.2	-2.3	-0.4	0.2	0.0	-0.6	-0.8
Falls in the last year	0.3	0.5	1.1	-0.1	0.9	0.8	0.3	1.1	0.0
Hair/balding pattern: Pattern 3	2.0	3.1	6.5	0.3	0.9	2.1	2.5	1.9	1.7
Number of live births	0.1	0.1	0.3	-0.1	0.3	0.0	0.1	-0.5	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.9	1.0	-0.9	-0.7	-0.5	0.1	-0.4
Pulse rate	1.3	2.2	5.2	-2.3	-1.7	0.5	0.8	1.2	-1.7
Happiness	1.0	1.2	2.9	-0.4	0.6	-1.1	-1.7	-0.9	-1.2
Noisy workplace	0.3	0.4	1.3	1.2	-0.4	0.1	0.1	0.1	1.0
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.0	0.4	1.0	-1.2	-1.7	-1.6	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.7	-0.2	-0.8	-1.0	-1.3	-0.8	-1.2
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	-0.4	-0.3	0.6	0.5	0.1	0.6
Asthma	0.1	0.1	0.2	0.3	0.4	-0.2	-0.2	0.4	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	-0.1	0.0	0.3	0.1	0.4	-0.0
Medication: Cholesterol lowering	0.2	0.3	0.5	-0.7	0.7	0.4	0.7	0.2	0.2
Depression (self-reported)	0.7	0.8	2.7	-1.6	-1.2	0.5	-0.3	-0.5	-0.4
Medication: Lansoprazole	0.4	0.5	1.1	0.5	-0.9	-0.0	0.7	1.0	-0.2
Prospective memory result	0.8	1.0	2.5	-0.0	-0.0	1.4	1.1	0.7	1.6
Lung cancer (father)	0.3	0.3	0.7	0.8	-0.5	0.2	0.5	0.8	0.3
Illnesses of mother	1.0	1.2	2.1	1.4	-1.5	-0.9	-1.3	-0.7	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.5	1.0	0.4	-0.5	-1.0	-0.6	0.1	-1.0
Pulse wave Arterial Stiffness index	0.5	0.6	2.4	-1.5	0.8	0.2	0.2	-0.3	-0.4
Impedance of arm (left)	0.7	3.2	7.9	-2.2	2.8	1.7	1.7	0.6	0.5
Arm fat mass (right)	0.0	0.1	0.3	-0.5	-0.1	0.4	0.4	-0.0	0.2
Trunk predicted mass	0.3	1.9	5.0	0.4	-2.2	-1.2	-1.6	-1.3	-0.6
Standing height	0.2	2.2	5.6	-1.4	-0.6	-1.0	-1.7	-2.4	-1.1
Length of working week for main job	0.1	0.1	0.4	-0.4	-0.6	0.0	-0.1	-0.1	-0.5
Exposure to tobacco smoke at home	0.9	1.1	4.8	-2.2	-0.6	0.4	0.4	-0.9	0.3
Breastfed as a baby	1.6	1.9	5.0	-0.5	2.1	-0.9	-1.1	-2.2	-0.1
Tense / ‘highly strung’	0.5	0.9	2.3	-0.1	1.5	0.7	0.8	1.3	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.1	-1.3	1.4	0.9	0.5	0.3	-0.3
Hair/balding pattern: Pattern 4	0.5	1.2	5.3	0.0	-2.3	0.7	0.8	0.8	0.4
Birth weight of first child	1.3	2.4	12.2	0.7	3.5	0.6	0.6	0.2	1.1
Peak expiratory flow (PEF)	0.0	0.1	0.3	0.4	-0.5	-0.1	-0.0	-0.0	0.2
Pulse wave reflection index	0.8	1.0	3.8	0.7	1.9	-0.5	-0.6	-0.8	0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.4	-0.4	-0.0	0.6	-0.1	0.4	0.3
Loud music exposure frequency	0.5	0.6	1.4	0.2	-1.2	-0.4	-0.9	-1.0	0.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.9	0.2	0.4	-0.5	-0.9	-1.4	0.3
Mouth/teeth dental problems: Bleeding gums	2.3	3.0	6.2	-0.3	1.0	2.5	2.1	1.1	2.3
Blood clot in the leg (DVT)	0.5	0.7	1.7	-0.5	-0.9	1.0	0.3	-0.5	1.3
Medication: Paracetamol	0.2	0.4	0.9	-0.2	-0.6	0.7	0.6	1.0	0.1
Headache pain in last month	0.8	1.4	2.3	-1.5	-1.1	0.6	1.0	1.5	-1.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.1	0.2	-0.5	-1.2	-1.8	-1.4	-0.6
Glaucoma (self-reported)	0.6	0.6	2.0	-1.0	-1.4	0.2	0.7	0.6	-0.3
Gout (self-reported)	0.2	0.2	0.8	-0.6	-0.9	0.2	-0.2	-0.3	-0.2
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	7.3	2.7	0.8	-0.6	-0.3	-0.0	1.2
Medication: Amlodipine	0.7	1.0	1.8	-1.4	0.4	-0.7	-0.8	-1.3	-0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.6	-0.5	1.3	1.0	0.6	-0.1	1.1
Birth weight	1.0	2.1	4.5	0.2	2.1	-1.5	-1.8	-1.4	-0.9
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.2	0.5	0.0	0.8	0.2	0.1	1.1
High blood pressure (siblings)	1.8	2.6	4.5	-1.0	0.5	-1.8	-1.9	-2.1	-1.6
Forced vital capacity (FVC), Best measure	0.1	0.2	0.5	0.5	-0.1	-0.7	-0.3	0.2	-0.5
Body fat percentage	0.4	1.4	2.6	-0.8	1.3	1.5	1.6	0.9	0.8
Leg fat percentage (right)	0.6	2.3	4.3	0.0	2.1	1.6	1.8	1.4	1.3
Arm fat-free mass (right)	0.3	1.7	5.7	0.5	-2.4	-1.0	-1.4	-0.9	-0.7
Exposure to tobacco smoke outside home	0.7	0.9	1.7	-0.4	0.3	-0.9	-1.3	-1.3	-0.9
Comparative body size at age 10	0.1	0.4	0.8	0.2	-0.7	-0.8	-0.9	-0.5	-0.2
Number of full brothers	1.3	1.6	3.4	-1.8	0.4	-1.1	-0.9	-1.0	-1.9
Worry too long after embarrassment	0.3	0.6	2.1	-1.5	-0.8	0.6	0.0	-0.4	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	5.1	-2.2	0.5	1.4	0.7	0.1	-0.1
Wheeze or whistling in the chest in last year	1.8	3.2	6.0	-1.2	-1.1	-1.7	-2.5	-2.0	-1.8
Number of children fathered	0.7	0.8	2.5	-1.1	-1.6	-0.2	-0.3	-1.0	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.0	-1.7	-0.4	-0.5	-1.4	-1.7	-0.8
Age at first live birth	0.4	0.7	1.5	0.9	1.0	0.7	0.4	0.3	1.2
Pulse wave peak to peak time	0.4	0.5	1.9	1.4	-0.6	-0.6	-0.6	-0.1	-0.1
Health satisfaction	2.0	2.5	5.1	-1.5	1.5	-1.3	-1.8	-0.9	-2.3
Shortness of breath walking on level ground	1.3	1.5	3.6	-0.7	-1.9	-0.9	-0.8	0.0	-1.8
Qualifications: College or University degree	0.0	0.1	0.3	-0.1	0.3	0.5	0.3	-0.2	0.5
Eye problems/disorders: None of the above	0.7	0.8	1.5	-0.3	0.2	-1.1	-1.2	-0.7	-1.2
Mouth/teeth dental problems: Loose teeth	2.8	3.3	4.7	0.8	-1.5	2.2	2.2	1.9	2.1
Emphysema/chronic bronchitis	1.9	2.1	4.6	-0.5	-0.3	-1.8	-1.8	-1.0	-2.1
Medication for pain relief, constipation, heartburn	0.4	0.7	1.8	1.3	0.5	-0.6	-0.6	-0.9	0.8
Neck or shoulder pain in last month	0.5	0.7	3.6	-0.1	-1.9	-0.5	-0.2	-0.0	-0.8
Medication: Blood pressure	0.6	1.0	2.1	0.5	0.6	1.0	1.4	1.4	0.5
Angina (self-reported)	0.1	0.1	0.3	-0.4	0.1	0.2	0.4	-0.2	0.6
Migraine (self-reported)	1.0	1.3	2.8	0.1	-1.7	0.1	0.6	1.6	-1.3
Medication: Ibuprofen	0.1	0.1	0.3	-0.2	0.6	0.3	0.1	0.4	-0.2
Medication: Allopurinol	1.5	2.0	4.2	-1.6	0.1	-1.0	-1.6	-2.0	-1.3
Medication: Omeprazole	0.1	0.2	0.5	-0.4	0.3	-0.1	0.1	0.5	-0.7
Medication: Seretide 50 evohaler	1.0	1.2	2.0	-1.4	0.7	-0.8	-0.9	-1.4	-0.9
Mean time to correctly identify matches	0.1	0.1	0.4	-0.6	-0.3	-0.0	0.1	-0.2	-0.2
Heart disease (mother)	0.8	0.9	2.0	-1.4	1.4	0.6	1.0	0.4	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.8	1.4	-1.1	0.4	0.3	-0.2	1.7
Whole body fat mass	0.1	0.3	0.6	-0.5	0.3	0.8	0.8	0.2	0.5
Leg fat mass (right)	0.1	0.3	0.5	0.0	0.6	0.6	0.7	0.3	0.7
Arm predicted mass (right)	0.3	1.3	5.7	0.5	-2.4	-0.6	-1.0	-0.8	-0.3
Pulse rate, automated reading	0.2	0.6	2.0	-1.4	0.4	0.3	0.1	0.3	-1.1
Alcohol intake frequency.	1.2	2.8	5.7	0.9	-1.4	1.4	2.3	2.4	1.2
Comparative height size at age 10	0.3	1.9	3.8	0.3	-1.6	-1.4	-1.8	-1.9	-0.4
Number of full sisters	0.7	0.9	2.9	-0.4	-1.7	0.4	1.1	1.1	-0.0
Suffer from ‘nerves’	1.4	2.1	4.3	-0.4	1.4	1.5	2.0	2.1	0.4
Overall health rating	0.8	1.7	4.4	-1.8	-0.7	-1.1	-0.7	-0.3	-2.1
Chest pain or discomfort	1.1	1.6	2.9	-1.6	-0.8	-1.0	-1.2	-1.7	-1.0
Had major operations	1.9	2.2	5.5	-0.6	0.2	-1.5	-2.1	-2.3	-0.8
Age at last live birth	0.7	1.0	2.4	1.2	1.5	0.4	0.0	-0.3	1.6
Family relationship satisfaction	0.6	0.7	2.3	0.3	1.5	-0.3	-1.1	-0.7	0.0
Leg pain on walking	0.7	0.9	3.3	-0.3	-1.8	-0.4	-1.0	-0.6	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	5.6	1.3	-0.1	1.1	0.7	-0.2	2.4
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.0	0.3	-1.4	-1.2	-1.1	-0.6	-0.9
Illness, injury, bereavement, stress in last 2 years	3.2	4.0	8.0	1.0	-0.2	2.4	2.5	1.6	2.8
Medication: Aspirin	0.5	0.6	2.4	-0.8	-0.2	-0.3	0.2	0.7	-1.5
Supplements: Vitamin C	0.9	1.1	3.7	1.9	0.7	0.1	0.3	1.1	1.0
Knee pain experienced in last month	1.3	2.1	4.0	-0.3	-0.2	-1.8	-1.8	-1.4	-2.0
Hypertension (Self-reported)	0.6	1.6	6.6	0.4	2.6	-1.1	-0.4	-0.0	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.7	-0.5	-1.3	0.3	0.1	-0.4	-0.0
Illnesses of father: Heart disease	0.4	0.6	3.0	-0.1	-1.7	0.0	-0.3	-0.4	-0.3
Illnesses of siblings: Diabetes	1.4	1.7	2.7	-1.6	-1.3	1.6	1.6	0.5	0.8
Smoking status: Previous	1.3	1.9	4.8	-0.2	0.3	-1.3	-2.1	-2.2	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	4.7	-0.6	-2.2	-0.8	-0.8	-0.5	-1.1
Whole body fat-free mass	0.4	2.1	7.1	0.1	-2.7	-1.0	-1.5	-1.4	-0.5
Leg fat-free mass (right)	0.6	3.1	12.8	-0.2	-3.6	-0.9	-1.5	-1.6	-0.4
Arm fat percentage (left)	0.2	0.8	1.7	-0.7	0.6	1.1	1.3	0.9	0.5
Average weekly red wine intake	0.4	0.6	2.1	0.8	0.1	0.8	0.1	-0.2	1.5
Handedness (chirality/laterality): Left-handed	1.3	1.5	2.8	-1.6	1.1	1.2	1.7	1.0	0.2
Mood swings	0.6	1.0	2.8	-1.7	-0.3	-0.4	-0.9	-0.4	-1.4
Loneliness, isolation	0.4	0.6	1.8	-0.3	-0.0	1.4	0.5	0.3	1.2
Long-standing illness, disability or infirmity	0.2	0.4	0.8	0.6	-0.3	0.6	0.5	0.5	0.9
Ever had bowel cancer screening	0.5	0.5	1.4	0.2	0.7	0.5	1.2	0.9	0.3
Diabetes diagnosed by doctor	1.1	1.8	4.5	-0.3	0.6	-1.9	-1.3	-0.8	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.3	-0.6	-0.3	-0.4	-0.7	0.0
Friendships satisfaction	1.1	1.4	3.0	0.4	1.3	-1.2	-1.7	-0.7	-1.2
Qualifications: nursing, teaching	0.1	0.2	0.7	0.3	-0.8	0.1	0.3	-0.5	0.5
Commuting to job workplace: Walk	2.1	2.3	4.7	-0.8	0.0	2.2	2.0	1.7	1.1
Eye problems/disorders: Cataract	1.5	1.8	5.0	2.2	0.2	0.8	0.8	1.1	1.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.5	1.1	-1.0	0.2	0.4	1.2	0.5
Medication for cholesterol	1.5	2.3	8.2	-1.9	-2.9	0.6	0.9	0.4	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.2	0.1	-0.2	1.1	0.8	0.8	0.4
Back pain experienced in last month	0.8	1.2	2.9	-1.1	-1.7	1.2	1.1	0.4	0.6
Mineral and other dietary supplements	0.7	0.9	2.2	-1.5	-0.9	1.3	0.9	0.3	0.3
Breast cancer (self-reported)	0.4	0.5	1.0	0.4	0.7	-0.8	-1.0	-0.6	-0.3
Asthma (self-reported)	0.0	0.1	0.2	0.3	0.1	-0.2	-0.2	0.4	-0.3
Osteoporosis (self-reported)	0.1	0.1	0.3	0.5	0.2	0.1	0.3	0.2	0.5
Osteoarthritis (self-reported)	0.4	0.5	1.6	-1.3	-0.5	-0.2	0.4	0.3	-1.0
Medication: Aspirin	0.6	0.8	3.1	-1.0	-0.0	-0.4	0.2	0.7	-1.8
Medication: Gliclazide	0.6	0.6	1.4	0.4	0.1	-1.2	-1.0	-0.5	-1.0
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	0.2	0.6	-0.1	0.2	-0.1	0.4
Smoking status: Current	0.7	1.2	2.8	-1.7	-1.7	0.2	-0.5	-1.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	9.5	3.1	1.5	0.1	0.8	1.5	1.8
Whole body water mass	0.4	2.2	7.3	0.0	-2.7	-1.1	-1.5	-1.4	-0.6
Leg predicted mass (right)	0.6	3.1	13.2	-0.1	-3.6	-0.8	-1.4	-1.5	-0.4
Arm fat mass (left)	0.1	0.2	0.5	-0.6	-0.1	0.6	0.7	0.3	0.2
Number of self-reported non-cancer illnesses	0.6	1.0	2.1	-0.1	-0.9	1.1	1.4	1.0	0.9
Average weekly champagne plus white wine intake	1.3	1.7	3.0	-1.4	-0.9	-0.8	-1.5	-1.7	-1.4
Miserableness	0.5	0.8	2.4	-1.3	-1.5	0.6	0.4	0.7	-0.2
Guilty feelings	0.9	1.3	3.2	-0.8	-0.5	1.8	1.2	0.9	1.1
Wears glasses or contact lenses	0.6	0.7	3.1	-0.3	-1.8	-0.2	0.0	0.5	-0.8
Ever taken oral contraceptive pill	0.9	1.0	3.0	0.1	0.0	-1.0	-1.7	-1.2	-0.5
Hearing aid user	0.1	0.1	0.2	0.2	0.3	-0.0	-0.2	-0.5	0.3
Mother’s age at death	1.0	1.3	4.9	-2.2	0.3	0.2	0.8	0.4	-1.3
Financial situation satisfaction	0.1	0.2	0.4	-0.2	0.6	0.5	0.1	0.7	0.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.2	1.0	0.5	0.7	0.0	0.4	1.1
Commuting to job workplace: Public transport	0.5	0.6	1.9	-1.4	-0.1	-0.0	-0.1	0.2	-1.3
Eye problems/disorders: Glaucoma	0.6	0.8	3.1	-0.3	-1.8	-0.7	0.0	0.2	-0.9
Medication: Blood pressure	0.7	1.3	6.1	1.0	2.5	-0.1	0.0	-0.2	0.9
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.5	-0.7	-0.4	0.0	-0.1	0.0	-0.6
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.4	1.9	0.5	-0.3	0.4	1.2	0.0
High cholesterol (Self-reported)	0.7	1.2	3.7	0.8	1.9	0.5	0.7	0.5	1.3
Medication: Bendroflumethiazide	0.3	0.4	0.7	0.6	0.8	0.6	0.5	0.8	0.2
Medication: Paracetamol	0.2	0.2	0.6	0.2	-0.4	0.6	0.4	0.8	0.3
Medication: Lisinopril	1.0	1.3	3.5	0.1	0.5	-1.9	-1.1	-1.2	-1.2
Medication: Atorvastatin	0.4	0.5	1.1	-0.7	-1.1	-0.7	-0.2	-0.4	-0.7
Illnesses of father: High blood pressure	0.2	0.2	0.7	0.8	0.6	-0.2	-0.2	0.3	0.3
Alcohol drinker status: Never	4.2	5.1	9.4	0.6	-1.8	2.5	3.1	2.7	2.0
Ever smoked	2.0	3.4	7.1	-2.4	-0.2	-1.0	-2.1	-2.7	-1.6
Basal metabolic rate	0.3	1.7	5.9	-0.1	-2.4	-0.8	-1.2	-1.3	-0.4
Leg fat percentage (left)	0.4	1.6	2.9	0.1	1.6	1.4	1.7	1.3	0.9
Arm fat-free mass (left)	0.2	1.0	3.8	0.0	-2.0	-0.6	-1.0	-0.9	-0.4
Number of operations (self-reported)	1.8	2.7	6.1	0.4	0.5	-2.1	-2.5	-1.9	-1.4
Average weekly beer plus cider intake	0.8	1.1	3.6	-1.1	1.9	-0.3	-0.7	-1.2	-0.3
Irritability	0.7	1.1	4.4	0.1	-2.1	0.9	0.8	0.7	0.5
Risk taking	1.5	2.2	4.2	0.7	2.0	-1.5	-1.8	-1.7	-0.5
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.4	-0.0	-1.2	-0.4	-0.5	-0.7	-0.4
Fractured/broken bones in last 5 years	0.2	0.3	0.7	0.6	0.2	-0.6	-0.8	-0.7	-0.2
Age started oral contraceptive pill	1.6	2.0	4.2	2.0	-0.5	1.1	1.2	1.4	1.7
Diastolic blood pressure, automated reading	0.6	1.8	6.7	0.1	2.6	1.2	1.1	0.9	0.8
Ever depressed for a whole week	0.4	0.5	1.3	-0.9	1.2	0.4	-0.3	0.2	-0.7
Unable to work because of sickness or disability	0.3	0.4	1.0	-0.0	-0.5	-0.7	-0.9	0.0	-1.0
Commuting to job workplace: Cycle	1.7	2.1	3.6	-0.2	1.3	1.8	1.9	1.0	1.8
Myopia	1.1	1.6	3.1	1.8	-1.3	0.9	0.9	1.2	1.3
Vascular/heart problems diagnosed by doctor	0.5	1.3	6.0	-0.6	-2.5	0.8	0.0	-0.3	0.9
Cholesterol lowering medication	0.6	0.9	2.8	1.4	1.7	-0.6	-0.5	-0.0	0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.5	-0.1	-0.2	-0.4	-0.3	0.1	-0.7
Pain experienced in last month	0.6	1.0	2.8	0.2	1.7	0.9	0.7	0.4	1.2
Supplements: Calcium	1.7	1.9	4.0	0.6	2.0	-1.6	-1.4	-0.6	-1.4
Basal cell carcinoma (self-reported)	2.0	2.4	4.2	-2.1	-1.2	-0.8	-1.6	-1.7	-1.6
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.6	0.2	-1.6	-0.8	-0.5	-0.0	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.3	-0.7	-0.9	0.9	0.4	-0.5	1.1
Heart disease (siblings)	0.1	0.1	0.4	0.0	-0.2	-0.6	-0.2	-0.2	-0.6
Alcohol drinker status: Previous	0.5	0.5	1.1	-0.2	-0.6	0.9	1.1	0.8	0.6
Pack years of smoking	1.2	1.8	3.2	-0.8	-0.7	-1.6	-1.8	-1.5	-1.4
Impedance of whole body	0.8	4.3	11.8	-2.1	3.4	2.0	2.0	1.0	0.5
Leg fat mass (left)	0.1	0.2	0.4	0.1	0.2	0.6	0.6	0.3	0.6
Arm predicted mass (left)	0.2	0.8	3.0	0.1	-1.7	-0.5	-0.8	-0.9	-0.2