Best TWAS P=1.71e-09 · Best GWAS P=5.04e-09 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | RP11-71H17.9 | 0.15 | 0.13 | lasso | 4 | 0.13 | 4.8e-11 | 5.8 | 5.9 | 4.5e-09 | 0.96 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Visceral Omentum | RP11-71H17.9 | 0.25 | 0.20 | enet | 17 | 0.23 | 4.8e-12 | 5.8 | 6.0 | 1.8e-09 | 0.96 | 0.02 | 0.98 | TRUE |
3 | GTEx | Adrenal Gland | RP11-71H17.9 | 0.29 | 0.21 | lasso | 6 | 0.20 | 7.2e-08 | 5.3 | 5.5 | 4.0e-08 | 0.91 | 0.02 | 0.98 | FALSE |
4 | GTEx | Artery Aorta | RP11-71H17.9 | 0.36 | 0.22 | enet | 16 | 0.22 | 1.6e-12 | 5.3 | 5.8 | 8.1e-09 | 0.94 | 0.03 | 0.97 | FALSE |
5 | GTEx | Artery Tibial | RP11-71H17.9 | 0.13 | 0.13 | enet | 12 | 0.13 | 3.7e-10 | 5.3 | 5.9 | 3.8e-09 | 0.94 | 0.03 | 0.97 | FALSE |
6 | GTEx | Brain Hypothalamus | RP11-71H17.9 | 0.39 | 0.13 | enet | 38 | 0.10 | 2.2e-03 | 5.7 | 5.2 | 2.5e-07 | 0.84 | 0.02 | 0.95 | FALSE |
7 | GTEx | Brain Nucleus accumbens basal ganglia | RP11-71H17.9 | 0.21 | 0.06 | enet | 15 | 0.07 | 5.0e-03 | 5.8 | 5.9 | 3.2e-09 | 0.97 | 0.03 | 0.88 | FALSE |
8 | GTEx | Cells EBV-transformed lymphocytes | RP11-71H17.9 | 0.44 | 0.38 | enet | 15 | 0.37 | 6.0e-13 | 5.8 | 5.6 | 2.5e-08 | 0.98 | 0.01 | 0.99 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | ITGB5 | 0.16 | 0.14 | lasso | 7 | 0.11 | 1.8e-08 | 5.3 | 5.6 | 2.4e-08 | 0.83 | 0.09 | 0.91 | FALSE |
10 | GTEx | Cells Transformed fibroblasts | RP11-71H17.9 | 0.24 | 0.29 | enet | 15 | 0.30 | 6.1e-23 | 5.8 | 5.6 | 1.9e-08 | 0.98 | 0.01 | 0.99 | FALSE |
11 | GTEx | Colon Sigmoid | RP11-71H17.9 | 0.18 | 0.02 | enet | 10 | 0.05 | 6.7e-03 | 5.2 | 5.7 | 1.6e-08 | 0.97 | 0.02 | 0.98 | FALSE |
12 | GTEx | Colon Transverse | RP11-71H17.9 | 0.18 | 0.24 | lasso | 5 | 0.22 | 5.0e-11 | 5.8 | 5.8 | 6.2e-09 | 1.00 | 0.01 | 0.99 | FALSE |
13 | GTEx | Esophagus Muscularis | RP11-71H17.9 | 0.21 | 0.22 | lasso | 5 | 0.21 | 4.6e-13 | 5.8 | 5.6 | 1.9e-08 | 0.99 | 0.01 | 0.99 | FALSE |
14 | GTEx | Heart Left Ventricle | RP11-71H17.9 | 0.18 | 0.21 | lasso | 9 | 0.19 | 2.6e-10 | 5.7 | 5.7 | 9.7e-09 | 0.99 | 0.01 | 0.99 | FALSE |
15 | GTEx | Lung | RP11-71H17.9 | 0.16 | 0.16 | lasso | 4 | 0.16 | 6.9e-12 | 5.7 | 5.8 | 5.4e-09 | 0.99 | 0.01 | 0.99 | FALSE |
16 | GTEx | Muscle Skeletal | RP11-71H17.9 | 0.12 | 0.07 | lasso | 4 | 0.06 | 8.6e-07 | 5.7 | 6.0 | 1.7e-09 | 0.90 | 0.01 | 0.99 | FALSE |
17 | GTEx | Pancreas | RP11-71H17.9 | 0.19 | 0.22 | lasso | 3 | 0.18 | 6.4e-08 | 5.3 | 5.3 | 1.1e-07 | 0.97 | 0.03 | 0.97 | FALSE |
18 | GTEx | Small Intestine Terminal Ileum | RP11-71H17.9 | 0.32 | 0.15 | lasso | 10 | 0.13 | 7.3e-04 | 5.7 | 5.5 | 2.9e-08 | 0.97 | 0.02 | 0.95 | FALSE |
19 | GTEx | Stomach | RP11-71H17.9 | 0.21 | 0.24 | lasso | 3 | 0.20 | 4.4e-10 | 5.7 | 5.7 | 1.2e-08 | 0.99 | 0.01 | 0.99 | FALSE |
20 | YFS | Blood | UMPS | 0.02 | 0.01 | bslmm | 622 | 0.01 | 4.3e-04 | 5.3 | 5.3 | 1.0e-07 | 0.79 | 0.02 | 0.97 | FALSE |
21 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ITGB5 | 0.03 | 0.02 | blup | 116 | 0.03 | 8.2e-05 | 2.9 | 5.2 | 2.3e-07 | 0.83 | 0.12 | 0.74 | FALSE |