Hub : Genes

UMPS

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1630	0.0340	6.6e-15	0.182	0.160	0.191	0.197	0.190	1.3e-21	5.6e-19	1.1e-22	1.7e-23	1.3e-22
2	GTEx	Cells Transformed fibroblasts	0.1050	0.0380	1.4e-03	0.025	NA	0.013	NA	0.014	5.2e-03	NA	3.6e-02	NA	2.8e-02
3	GTEx	Esophagus Mucosa	0.1220	0.0420	6.2e-04	0.119	NA	0.118	NA	0.111	2.5e-08	NA	2.8e-08	NA	7.8e-08
4	GTEx	Lung	0.1391	0.0452	1.4e-03	-0.003	NA	0.017	NA	0.005	7.5e-01	NA	1.6e-02	NA	1.2e-01
5	GTEx	Nerve Tibial	0.1279	0.0530	6.9e-03	0.013	NA	0.104	NA	0.043	4.1e-02	NA	7.9e-08	NA	5.2e-04
6	GTEx	Skin Sun Exposed Lower leg	0.1090	0.0380	1.4e-03	0.030	NA	0.012	NA	0.039	1.5e-03	NA	3.4e-02	NA	3.6e-04
7	YFS	Blood	0.0194	0.0075	5.5e-04	0.008	0.008	0.006	0.009	0.005	8.6e-04	8.3e-04	2.5e-03	4.3e-04	7.8e-03
8	TCGA	Brain Lower Grade Glioma	0.0559	0.0273	4.5e-04	0.001	0.032	0.026	NA	0.018	2.1e-01	1.4e-04	5.0e-04	NA	3.8e-03
9	TCGA	Pancreatic Adenocarcinoma	0.1540	0.0860	4.1e-03	0.083	0.033	0.028	NA	0.056	2.3e-04	1.5e-02	2.4e-02	NA	2.3e-03
10	TCGA	Testicular Germ Cell Tumors	0.1120	0.0610	3.7e-03	0.084	0.058	0.090	NA	0.087	6.9e-04	4.3e-03	4.5e-04	NA	5.3e-04
11	TCGA	Thyroid Carcinoma	0.0410	0.0220	7.5e-04	0.044	0.034	0.033	NA	0.044	3.8e-05	2.8e-04	3.3e-04	NA	3.8e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.4	0.6	1.8	1.0	-0.3	-0.6	1.4	0.1	-0.5	0.4	-1.0	-1.1	0.5	0.3
Bipolar Disorder or Schizophrenia	0.7	1.8	7.8	-1.0	1.2	1.3	0.4	-0.5	1.4	-1.6	-0.5	0.5	2.8	1.4
Depressed Affect (Nagel 2018)	0.1	0.3	1.5	0.3	1.2	-0.7	0.3	-0.0	0.1	-0.7	0.5	0.0	0.5	-0.1
Depression (Nagel 2018)	0.2	0.3	0.9	-0.6	-0.0	-0.5	-0.9	-0.1	0.6	-0.3	0.9	-0.1	-0.5	-0.5
Intelligence (Savage-Jansen 2018)	0.9	2.6	5.0	1.7	-1.2	-2.2	-1.6	0.2	-1.8	1.6	-1.4	-2.2	-1.7	-1.4
Neuroticism (Nagel 2018)	0.5	1.3	3.1	1.7	0.4	-1.5	-0.3	-1.0	-0.9	0.7	-1.8	-1.1	-0.1	-1.4
Schizophrenia (2018)	1.8	3.7	10.2	-2.4	1.7	2.2	-0.5	-0.9	2.2	-2.4	0.2	1.6	3.2	1.6
Schizophrenia vs Biploar Disorder	0.8	1.1	4.0	-0.4	0.9	2.0	-1.3	0.2	1.2	-1.1	0.8	1.1	0.2	0.7
Worry (Nagel 2018)	0.0	0.1	0.2	0.3	-0.1	0.2	0.5	-0.1	0.3	-0.3	-0.4	0.4	0.4	-0.1
Alzheimer’s Disease (in mother)	0.5	0.6	1.6	0.4	0.1	-0.6	-0.2	1.2	-1.1	0.9	0.8	-0.6	-1.2	-0.6
Alzheimer’s Disease (in father)	0.7	0.7	1.4	-0.7	-1.2	0.7	1.1	0.8	0.6	-0.5	1.1	1.1	-0.5	0.7
Alzheimer’s Disease (including proxy)	0.4	0.5	1.4	-0.3	-0.7	-0.1	1.1	1.2	-0.3	0.4	1.0	0.0	-1.1	0.1
Crohns Disease (2017)	1.0	2.2	4.4	-0.2	-1.1	-1.5	-1.6	-0.9	-1.6	2.1	-1.8	-1.7	-1.0	-1.8
Irritable Bowel Disease (IBD)	0.8	2.0	7.7	0.8	-1.1	-1.3	-1.2	-1.4	-1.4	2.8	-1.4	-1.1	-0.9	-1.4
Ulcerative Colitis (UC)	0.5	0.9	4.4	0.6	-1.3	-0.2	-0.7	-1.5	0.0	2.1	-0.1	0.4	-0.4	-0.1
Major Depression (MDD)	0.6	0.8	2.5	0.0	0.1	-1.6	-1.0	-0.6	-1.1	0.7	-1.3	-1.0	0.0	-0.5
Reaction Time	0.5	0.9	4.8	-2.2	-0.8	-0.1	0.8	-1.0	0.8	-1.3	0.1	-0.1	-0.5	0.4
Verbal and Numeric Reasoning (VNR)	1.5	3.7	7.5	1.5	-1.6	-2.4	-1.4	-0.1	-2.0	2.2	-2.0	-2.7	-2.0	-1.9
Breast Cancer	0.3	0.8	3.4	0.9	0.5	-0.7	-0.4	0.6	-1.8	0.2	-1.1	-0.9	-0.6	-1.2
Ovarian Cancer	0.2	0.3	1.7	0.6	0.4	-0.2	1.3	-0.1	0.6	0.8	-0.1	-0.2	0.1	0.4
Prostate Cancer	1.0	1.4	2.8	1.7	-1.5	-1.2	0.3	-1.2	0.3	1.3	-1.4	-1.1	-1.0	-1.2
Age at First Birth	1.4	2.1	4.5	0.9	-0.8	-1.5	-0.1	-0.5	-2.0	1.9	-2.1	-1.5	-1.4	-1.5
Bipolar Disorder (2011)	0.1	0.1	0.2	-0.1	0.2	-0.2	-0.4	0.1	-0.5	0.5	-0.2	-0.2	0.2	-0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.5	0.0	-0.5	-0.2	-0.1	-0.2	-0.6	-0.1	-0.2	-0.7	0.0	-0.2
Coronary Artery Disease (CAD)	0.5	0.6	2.0	-0.8	-0.4	0.1	0.6	-0.4	0.7	-0.1	1.4	1.2	0.0	1.0
Crohns Disease (2012)	2.2	3.5	7.8	0.1	-0.8	-2.4	-1.7	-1.2	-1.8	2.8	-2.3	-2.4	-1.1	-2.1
Mean Putamen Volume	0.6	0.7	3.1	0.8	-0.6	-1.2	-0.9	-0.2	-1.8	0.3	-0.9	-0.6	-0.2	-0.5
Fasting Glucose	0.6	0.7	3.7	-0.2	1.9	-0.5	0.8	-0.4	-0.7	0.7	-0.6	-1.4	0.4	-0.3
HbA1C	1.4	1.5	3.9	0.7	1.1	-0.9	-1.9	-1.2	-1.1	1.4	-0.9	-0.7	-1.0	-2.0
HDL Cholesterol	0.4	0.6	4.1	1.2	0.9	-0.2	0.0	-0.3	-0.0	2.0	-0.6	-0.2	-0.1	0.0
LDL Cholesterol	1.0	1.6	4.9	2.2	-1.5	-1.5	0.4	0.4	-1.4	1.0	-0.4	-1.5	-1.6	-0.8
Lupus	0.2	0.3	0.7	-0.9	-0.6	0.6	0.7	0.2	0.7	-0.5	0.4	-0.0	-0.2	0.5
Neuroticism (2016)	0.9	1.3	2.9	-0.1	-1.5	-1.4	-1.7	-1.7	-0.2	1.0	-1.7	-0.9	-0.2	-0.4
Primary Biliary Cirrhosis	0.6	0.9	3.4	-1.6	0.6	0.6	1.9	1.0	0.5	-0.8	0.7	-0.1	0.7	0.1
Rheumatoid Arthritis	1.2	1.6	8.4	-1.1	-0.1	1.4	1.6	-0.1	2.9	-1.0	0.2	0.5	0.9	1.2
Schizophrenia (2014)	1.8	3.9	8.5	-2.4	1.6	2.6	1.4	0.2	1.8	-2.8	0.3	1.5	2.9	1.9
Triglycerides	0.6	1.0	7.8	0.1	-2.8	-0.6	-0.4	-0.5	-0.2	-0.2	-0.7	-0.3	-0.8	-0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.7	0.3	0.6	-0.4	0.4	0.0	-0.3	-0.1	-0.8	-0.0	0.8	-0.3
Ulcerative Colitis	2.1	3.0	9.3	2.0	-1.3	-1.7	-1.1	-2.0	-1.5	3.1	-2.0	-0.9	-1.0	-1.5
Blood Eosinophil Count	0.1	0.6	1.8	0.6	-0.9	0.9	0.9	-1.1	0.3	-0.8	0.4	0.5	0.4	1.3
Blood Platelet Count	0.5	5.5	31.2	1.5	-0.1	-0.9	5.6	4.2	-0.9	-1.7	1.1	-0.4	-1.9	-0.4
Blood Red Count	0.2	2.3	7.1	0.3	-0.3	-2.4	1.8	1.4	-2.7	0.1	-0.8	-2.2	-0.9	-0.9
Blood White Count	0.5	3.9	9.7	-1.6	-1.6	2.5	1.4	-0.1	3.1	-1.7	1.7	2.1	1.4	2.9
Heel T-Score	2.1	16.6	28.3	4.1	-2.8	-4.8	-0.1	-0.5	-4.6	5.3	-3.6	-4.8	-4.8	-5.0
BMI	0.3	1.7	4.9	-2.2	-0.4	1.6	0.7	-1.3	1.0	-1.3	-0.4	0.8	1.6	1.5
Height	0.2	3.6	14.9	-0.8	-2.1	-0.6	0.2	3.2	-0.9	2.0	1.7	-0.6	-3.9	-1.1
Waist Hip Ratio (WHR)	0.2	0.7	4.4	-0.1	1.2	-0.0	-0.1	-0.2	-0.2	0.0	-1.2	-0.6	2.1	0.1
Systolic Blood Pressure	2.0	10.2	19.4	1.5	-3.7	-3.5	-3.5	-4.4	-2.7	4.3	-3.5	-2.2	-2.3	-2.1
Smoking Status	0.2	0.5	2.0	-0.9	0.1	0.5	1.4	0.1	0.6	-0.4	-0.7	0.2	1.3	-0.3
Allergy or Eczema	0.7	1.8	5.0	-0.3	-1.6	-1.0	0.5	-1.0	-0.7	-0.1	-1.6	-2.1	-2.2	-1.7
Cardiovascular Disease	0.4	1.2	8.3	-0.4	-1.1	-0.6	-0.6	-2.9	-0.3	0.3	-1.0	0.2	0.3	1.0
Hypothyroidism (self reported)	0.2	0.6	2.0	-0.2	-0.2	0.5	-0.1	-1.1	-0.3	-1.4	0.0	1.0	1.0	0.7
Respiratory disease	0.3	0.7	1.3	0.2	-1.1	1.0	1.1	-0.7	0.9	-0.7	-0.2	1.1	0.6	0.8
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.9	0.5	1.7	-1.3	-1.5	0.2	-0.6	1.2	-0.8	-1.4	-0.2	-0.1
Lung FEV1/FVC ratio	1.1	5.6	15.2	1.2	0.9	-3.0	-0.2	-0.7	-2.9	2.2	-2.4	-3.9	-3.0	-2.7
Lung FVC	0.4	2.1	7.2	0.4	2.7	-0.5	-0.9	-1.4	-1.6	-0.1	-2.3	-1.4	1.3	-1.3
Neuroticism	0.1	0.3	1.2	0.9	-0.4	-0.2	-1.1	-0.3	0.4	0.1	-0.2	0.1	-0.0	-0.8
Chronotype (morning person)	0.6	1.4	3.3	-1.1	-1.3	0.9	1.4	-0.5	0.6	-1.4	1.0	1.8	1.1	1.3
Hair Pigment	0.1	3.6	9.2	1.5	1.9	-2.4	-0.9	-1.0	-1.3	1.9	-3.0	-2.8	0.3	-2.0
Tanning	0.1	0.8	3.0	0.0	-1.7	0.4	0.7	-1.4	0.6	-0.6	-0.3	1.5	0.5	0.8
Hand grip strength (left)	1.1	3.0	8.1	-1.1	0.6	2.8	1.5	2.1	0.6	-0.1	2.3	2.7	0.8	1.7
Number of treatments/medications taken	0.6	1.1	4.7	-0.9	-1.6	0.2	-1.2	-2.2	0.7	-0.7	-0.5	0.4	0.7	1.0
Average weekly spirits intake	4.0	4.9	14.4	2.9	0.2	-2.1	-0.4	0.7	-2.4	3.8	-1.1	-2.6	-2.8	-2.2
Sensitivity / hurt feelings	0.4	0.7	3.6	1.9	0.4	-0.6	1.0	-0.6	-0.4	0.8	-0.9	-0.8	-0.2	-0.4
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.1	0.6	-1.0	-0.8	0.2	-1.0	0.2	0.3	-0.4	-0.5	-1.1	-0.6
Hearing difficulty/problems: Yes	0.5	0.7	3.4	-0.2	0.4	0.2	-0.3	-1.4	0.2	0.1	-1.3	0.0	1.8	0.6
Relative age of first facial hair	2.1	4.4	9.8	3.1	0.4	-2.2	-1.9	-1.1	-3.0	2.2	-1.6	-2.0	-1.6	-2.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.5	0.5	-1.1	-0.6	1.6	-0.9	-0.8	0.8	-1.0	-0.6	-0.2	-0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.5	-1.2	0.1	-0.5	-0.8	-0.5	0.6	0.5	-0.2	-0.6	0.8	0.2
Ever had hysterectomy (womb removed)	0.6	0.6	2.5	-0.5	-0.2	0.6	0.6	-0.9	0.9	-0.7	-0.3	0.6	1.6	1.0
Systolic blood pressure, automated reading	1.6	4.6	12.9	-0.3	-3.1	-1.8	-2.8	-3.6	-1.0	3.0	-2.1	-0.7	-1.3	-0.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.8	1.0	1.6	-0.7	0.7	0.9	-1.7	0.7	-0.6	-0.8	-0.2	-0.4
Angina	0.6	0.8	3.3	-0.6	0.7	1.0	1.8	0.9	0.3	-0.3	1.1	0.3	0.5	0.9
Medication for hormone replacement therapy	0.4	0.4	1.1	-0.2	0.5	-0.9	-0.6	0.1	-0.5	0.8	-0.6	-1.0	0.7	0.6
Vitamin and mineral supplements	0.7	1.0	4.0	-0.5	2.0	0.6	1.1	1.6	0.5	-0.2	0.5	0.4	1.3	0.6
Supplements: Zinc	0.6	0.7	2.5	0.2	1.6	0.6	-0.1	1.6	0.1	0.1	1.2	0.6	-0.4	0.4
Medication: Co-codamol	1.5	1.7	4.5	-0.8	-0.9	1.2	1.1	-0.8	2.1	-1.6	0.4	1.7	1.6	1.1
Medication: Metformin	0.1	0.1	0.4	-0.6	0.1	-0.3	-0.4	-0.2	0.3	0.4	-0.4	-0.1	0.0	-0.0
Diabetes (father)	6.1	7.5	12.8	3.6	1.4	-3.1	-3.3	-0.9	-3.3	3.5	-1.9	-2.1	-2.2	-3.2
Diabetes (mother)	0.4	0.5	1.5	-0.6	-0.3	0.5	-0.9	0.4	0.6	-0.4	0.9	1.1	0.5	1.2
Severe depression (siblings)	0.5	0.6	2.0	-0.7	-1.1	-0.2	0.4	-0.8	1.4	0.3	-0.6	-0.1	1.0	0.8
Pack years adult smoking proportion	1.1	1.6	3.4	-1.3	1.8	1.4	1.0	1.3	1.8	-1.2	0.9	1.2	0.9	0.6
Impedance of leg (right)	0.7	3.4	12.7	0.2	-2.3	0.5	2.5	1.7	1.8	-0.7	3.6	1.3	-1.6	1.7
Leg fat-free mass (left)	0.1	0.5	1.6	-1.2	1.3	0.7	-0.5	0.3	-0.5	0.8	-0.4	0.3	0.3	0.3
Trunk fat percentage	0.6	2.6	7.2	-2.7	-1.6	1.8	1.3	-0.1	2.1	-1.3	1.6	1.4	0.6	1.7
Hand grip strength (right)	0.9	2.4	7.5	-0.8	0.6	2.7	0.9	2.1	1.0	0.0	1.9	2.4	0.5	1.3
Townsend deprivation index at recruitment	0.4	0.6	3.1	-0.2	0.0	-0.2	0.4	-1.7	0.6	-0.8	-1.3	-0.6	0.4	-0.1
Current tobacco smoking	0.6	0.9	4.4	0.5	2.1	-0.2	1.4	1.2	-0.4	0.1	-0.6	-0.9	0.5	-0.9
Average weekly fortified wine intake	1.4	1.6	3.4	1.7	-1.2	-1.0	-0.4	0.6	-1.5	1.0	-1.0	-0.9	-1.8	-1.8
Maternal smoking around birth	1.3	1.8	7.6	0.5	2.1	1.4	-0.6	-0.2	0.8	-1.8	-0.9	-0.1	2.8	0.9
Fed-up feelings	0.3	0.5	3.1	-0.2	1.8	0.1	0.1	0.6	0.6	-0.4	0.8	0.1	0.6	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	1.6	-0.4	-0.1	0.0	-1.3	-0.7	0.1	-0.5	-0.1	-0.1	-0.1	-0.4
Relative age voice broke	1.6	2.4	7.7	2.8	0.1	-2.0	-1.5	-0.6	-2.1	1.7	-0.8	-0.7	-1.0	-1.6
Taking other prescription medications	0.4	0.6	2.0	1.0	-1.4	-0.4	-0.4	-1.3	-0.2	0.1	-1.3	-0.4	0.0	0.1
Age when periods started (menarche)	1.2	2.8	6.7	2.6	0.7	-1.2	-2.2	0.4	-1.4	2.3	-1.2	-1.8	-1.3	-1.9
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	5.8	-1.9	0.8	1.4	1.3	0.2	1.7	-2.0	0.4	0.9	2.4	2.0
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.5	8.3	2.5	-2.4	-2.7	-0.9	-1.1	-1.7	2.1	-1.4	-2.4	-2.9	-2.3
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.1	-0.2	-0.0	0.6	0.4	0.6	0.1	0.6	0.6	0.4	0.7
Qualifications: CSEs or equivalent	0.3	0.4	2.0	-0.4	-0.3	-0.1	-1.4	-1.2	0.4	-0.7	-0.3	-0.1	0.5	0.1
Serious illness, injury or assault to yourself	1.1	1.4	2.8	1.0	-1.7	-1.4	-0.7	-0.4	-0.9	1.5	-1.1	-1.1	-1.3	-1.3
High blood pressure	0.4	1.2	7.3	-1.1	-1.0	0.1	-1.1	-2.7	0.3	-0.0	-1.0	0.5	0.6	0.7
Hayfever, allergic rhinitis or eczema	0.8	1.7	4.6	-0.6	-1.7	-0.7	1.5	-0.3	-0.4	0.2	-1.2	-1.9	-2.1	-1.7
Multivitamins +/- minerals	1.1	1.4	4.1	1.5	-2.0	-0.9	-1.5	-1.1	-0.9	1.1	-0.1	-0.3	-1.5	-0.6
Stomach or abdominal pain in last month	0.4	0.5	3.1	0.5	-1.8	-0.3	0.7	-0.7	-0.2	-0.7	-0.1	-0.2	-0.3	0.4
Supplements: Glucosamine	0.9	1.1	2.6	1.2	-1.2	-0.4	0.1	-1.4	-0.9	1.0	-1.6	-0.4	-1.1	-1.3
Diverticular disease/diverticulitis (self-reported)	1.5	1.7	7.8	-1.3	0.0	1.3	1.8	-0.4	-0.5	-2.8	0.3	1.2	1.3	0.9
Medication: Atenolol	1.4	1.8	4.3	-1.6	0.5	1.0	1.4	-0.8	1.4	-1.2	0.9	0.9	1.9	2.1
Medication: Levothyroxine sodium	0.3	0.5	1.7	0.4	-0.3	0.8	-0.1	-0.2	-0.1	-1.3	0.3	1.1	0.9	0.6
Sitting height	0.2	1.5	4.6	-1.8	0.4	0.5	1.2	2.1	-0.2	0.3	1.8	0.9	-0.1	1.4
Chronic bronchitis/emphysema (father)	1.4	1.6	3.8	-0.3	1.4	2.0	0.7	0.6	2.0	-1.4	1.2	1.7	0.8	0.2
High blood pressure (mother)	0.6	0.8	1.7	1.3	-0.9	-1.1	1.3	-0.9	-0.8	1.0	-0.9	0.1	-0.2	0.5
Body mass index (BMI)	0.9	3.7	9.9	-3.1	0.8	2.7	0.8	-1.2	1.7	-2.3	0.3	2.1	2.3	1.8
Impedance of leg (left)	0.6	2.8	9.5	0.3	-2.3	0.3	2.3	1.5	1.6	-0.8	3.1	1.1	-1.7	1.1
Leg predicted mass (left)	0.1	0.5	1.7	-1.3	1.1	0.7	-0.6	0.2	-0.6	0.8	-0.4	0.3	0.3	0.3
Trunk fat mass	0.6	2.4	9.2	-3.0	-0.8	2.0	1.1	0.2	1.7	-1.1	1.4	1.5	0.8	1.7
Waist circumference	0.5	1.9	6.2	-2.5	0.3	1.9	0.8	-0.5	1.1	-1.5	-0.4	1.1	1.9	1.0
Number of incorrect matches in round	0.8	1.4	3.2	-1.3	1.2	1.7	0.3	-0.9	1.1	-1.1	-0.0	1.4	1.8	0.9
Past tobacco smoking	0.2	0.3	1.4	0.5	0.1	0.2	-1.2	0.5	-0.3	0.4	0.6	0.2	-0.4	0.5
Alcohol usually taken with meals	0.6	1.0	3.7	-1.9	-0.6	0.7	-1.0	0.0	0.6	-1.3	0.6	0.6	1.0	1.1
Nervous feelings	0.3	0.6	1.7	-0.4	0.4	0.7	0.7	0.2	0.8	-1.2	0.0	1.1	1.3	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.0	1.1	0.9	0.4	0.7	1.4	0.4	-1.3	-0.1	-0.1	-0.5	-0.7
Hearing difficulty/problems with background noise	1.1	1.8	7.0	-0.4	1.8	1.4	-0.5	-0.3	1.1	-1.5	-0.2	1.5	2.6	1.3
Hair/balding pattern: Pattern 2	0.4	0.5	2.5	1.0	-0.4	0.1	-1.6	-0.9	0.0	0.3	-0.7	-0.0	-0.3	-0.2
Had menopause	0.8	1.0	3.4	-0.9	-0.6	-0.7	-1.9	-1.0	-0.6	-0.1	-1.6	-0.7	1.1	-0.2
Had other major operations	0.9	1.1	3.0	0.8	-1.3	-1.1	0.9	-1.7	-0.9	1.1	-1.4	-0.3	-0.7	-0.9
Forced vital capacity (FVC)	0.2	0.9	3.7	-0.2	0.8	-0.2	-0.8	-0.1	-1.9	1.1	-0.9	-1.1	-0.8	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	5.0	2.2	-1.3	-1.5	-0.2	-0.6	-1.2	1.3	-0.9	-1.6	-2.2	-1.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.8	0.2	-0.5	-0.9	0.1	-1.2	-0.8	1.4	-1.2	-1.0	-0.2	-0.6
Qualifications: None of the above	0.8	1.7	3.6	-1.7	-0.0	1.7	0.4	-1.5	1.4	-1.9	0.6	1.6	1.4	0.8
Financial difficulties in last 2 years	0.4	0.6	3.6	1.0	-0.8	0.3	-0.2	-1.9	0.6	0.0	-0.6	0.0	-0.0	-0.1
Mouth/teeth dental problems	0.6	0.9	5.1	1.1	2.3	0.9	0.5	1.2	-0.3	-0.9	0.3	0.2	0.2	0.0
Heart attack	1.9	2.4	8.9	0.4	-2.1	-1.6	0.5	-0.5	-1.4	1.9	-0.3	-1.7	-3.0	-1.2
Allergy	0.3	0.7	1.8	1.1	0.8	-0.6	-1.3	-0.2	-0.8	0.9	0.0	0.3	1.2	0.5
Pain all over the body in last month	0.4	0.4	1.5	0.7	-1.2	-0.3	1.0	-0.8	0.2	0.1	0.4	0.6	-0.4	0.5
Diabetes (self-reported)	0.5	0.7	2.7	-0.2	1.6	-0.9	-0.9	-0.2	-0.7	0.2	-1.2	-1.0	0.3	-0.4
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	4.0	0.5	-1.4	-1.1	-0.3	-2.0	-0.7	1.5	-1.5	-0.8	-1.6	-1.9
Medication: Ramipril	0.5	0.6	1.8	-1.3	0.5	0.6	-0.2	0.9	0.9	-0.6	1.3	0.6	-0.3	0.4
Medication: Simvastatin	0.6	0.9	4.1	-1.1	-0.8	0.8	-0.0	-0.3	1.1	-2.0	0.9	0.8	0.1	1.0
Fluid intelligence score	2.3	4.7	11.2	1.7	-0.5	-2.7	-0.4	0.4	-2.8	2.9	-2.0	-3.4	-2.4	-2.0
Illnesses of siblings	2.1	3.0	6.9	1.2	0.9	-1.9	-1.8	1.1	-1.9	1.6	-0.6	-2.3	-2.0	-2.6
Neuroticism score	0.2	0.4	0.9	0.4	0.9	0.6	-0.3	-0.2	0.7	-0.7	0.1	0.9	0.9	0.0
Weight	0.5	2.4	9.5	-3.1	0.6	2.2	0.8	0.5	1.1	-1.1	1.1	1.6	1.1	1.7
Impedance of arm (right)	0.8	3.7	10.1	1.9	-3.2	-1.7	0.1	1.9	0.1	2.4	1.8	-1.4	-3.0	-0.6
Arm fat percentage (right)	0.5	1.8	4.5	-2.1	-0.9	1.9	0.9	-0.6	1.7	-0.9	0.7	1.4	1.1	1.6
Trunk fat-free mass	0.2	1.3	5.2	-2.0	2.3	1.3	-0.2	1.1	-0.6	0.1	0.3	0.9	0.8	0.6
Hip circumference	0.9	4.0	9.7	-3.1	-0.7	2.7	1.9	-0.0	2.0	-1.9	1.5	2.5	1.3	2.4
Time employed in main current job	0.6	0.7	2.7	-0.2	0.6	-0.8	-0.3	-0.0	-1.3	-0.1	-1.7	-1.2	0.8	-0.3
Alcohol intake versus 10 years previously	0.8	1.2	2.6	-1.5	-0.2	1.6	0.3	-0.6	1.4	-1.6	0.9	1.1	0.6	0.9
Father’s age at death	0.1	0.1	0.5	-0.4	0.1	-0.5	-0.7	0.3	-0.0	0.2	0.5	-0.1	-0.2	0.1
Worrier / anxious feelings	0.2	0.4	1.0	0.9	-0.8	-0.3	-0.5	-0.1	-0.1	0.5	-0.1	0.1	-0.9	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.4	-0.4	-0.5	-0.0	0.5	-0.2	0.1	-0.6	0.4	-0.1	-0.2	0.2
Falls in the last year	1.1	1.5	5.7	2.4	0.1	-1.0	-1.3	-0.9	-0.0	2.0	-0.7	-0.6	-0.9	-1.2
Hair/balding pattern: Pattern 3	0.3	0.5	2.4	0.6	-0.4	-0.1	-0.7	-1.5	-0.1	-0.5	-1.1	0.5	0.8	-0.2
Number of live births	0.4	0.5	1.4	-0.1	-0.8	0.4	-0.1	-0.7	0.7	-1.1	0.4	0.6	0.9	1.2
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	6.1	0.2	0.7	-1.0	-1.0	-0.4	-2.5	1.6	-1.3	-2.0	-1.8	-1.6
Pulse rate	0.3	0.4	1.3	0.6	1.1	0.2	0.7	0.6	0.8	-0.2	-0.1	0.3	1.0	0.7
Happiness	1.2	1.4	4.8	1.6	-0.8	-1.5	-1.4	0.1	-0.8	0.7	0.3	-1.3	-2.2	-0.8
Noisy workplace	1.8	2.2	5.5	-0.2	1.2	2.0	0.6	0.5	2.3	-0.4	1.5	2.1	1.7	1.6
Qualifications: A levels/AS levels or equivalent	0.9	2.0	7.0	1.1	-1.3	-1.3	-2.0	0.3	-1.2	1.6	0.2	-0.8	-2.6	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	6.1	2.5	-0.4	-0.9	0.4	0.2	-1.2	0.5	-0.5	-0.4	-1.2	-0.9
Mouth/teeth dental problems: Dentures	0.9	1.5	5.1	-2.2	-2.1	1.3	1.4	0.2	1.3	-0.4	0.7	0.8	0.3	0.8
Asthma	0.2	0.4	1.6	0.4	-1.3	0.4	0.7	-1.1	-0.1	-0.2	-0.9	0.3	-0.3	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.3	-0.1	0.3	0.7	0.1	-0.7	-0.1	-1.0	-0.3	0.1	1.0	1.1
Medication: Cholesterol lowering	1.5	2.4	7.1	-2.2	0.6	1.5	1.0	-0.3	1.3	-2.7	1.5	0.8	1.4	1.9
Depression (self-reported)	1.1	1.3	3.3	0.1	-0.4	-1.6	-0.6	-1.0	-0.2	1.8	-1.0	-1.8	-1.4	-0.9
Medication: Lansoprazole	0.3	0.4	1.1	-0.6	-0.5	0.3	0.5	-0.9	0.9	-1.1	-0.0	0.1	0.6	0.4
Prospective memory result	4.8	5.9	11.9	-2.9	1.0	2.2	3.4	0.6	2.9	-3.4	1.5	2.4	2.6	2.0
Lung cancer (father)	1.0	1.2	3.9	0.1	2.0	1.8	-0.6	1.2	0.1	-0.3	0.7	1.1	1.3	0.5
Illnesses of mother	0.2	0.3	1.4	-0.7	-0.3	0.1	-0.3	1.2	0.7	-0.6	0.1	-0.3	0.2	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.2	-0.8	0.4	-0.2	-1.0	-0.2	-1.5	0.9	-0.7	-1.4	-1.3	-0.8
Pulse wave Arterial Stiffness index	0.7	0.8	2.0	-0.1	-0.3	-1.4	-1.1	-1.3	-1.3	0.6	-0.8	-0.6	-0.2	-0.7
Impedance of arm (left)	0.7	3.1	12.0	1.7	-3.5	-1.5	0.1	1.4	0.4	1.8	1.7	-1.2	-2.6	-0.3
Arm fat mass (right)	0.5	2.2	7.3	-2.7	0.1	2.2	1.0	-0.3	1.5	-1.2	0.7	1.5	1.4	1.8
Trunk predicted mass	0.2	1.3	5.6	-2.0	2.4	1.3	-0.3	1.1	-0.7	0.1	0.2	0.9	0.8	0.5
Standing height	0.3	2.8	14.7	-0.6	-0.2	-0.4	0.2	3.8	-1.1	2.2	2.2	-0.5	-2.1	0.1
Length of working week for main job	0.5	0.6	1.3	0.1	0.9	-1.1	0.4	1.0	-0.8	0.2	-0.7	-1.1	-0.1	-0.9
Exposure to tobacco smoke at home	2.8	3.1	6.6	-1.6	2.4	2.1	0.7	1.0	1.7	-2.6	0.8	1.4	2.1	1.8
Breastfed as a baby	0.2	0.3	1.0	-0.4	0.2	0.0	-0.1	1.0	-1.0	0.8	-0.2	-0.3	-0.0	-0.1
Tense / ‘highly strung’	0.4	0.6	1.3	-0.9	-1.1	0.8	-0.2	0.2	0.8	-1.1	0.7	0.9	0.1	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.1	-0.1	1.3	1.9	0.7	2.0	1.6	-0.8	1.6	1.4	1.0	1.1
Hair/balding pattern: Pattern 4	1.0	2.5	4.6	1.3	1.3	-1.4	1.7	2.1	-1.7	2.1	-0.6	-1.7	-1.2	-1.8
Birth weight of first child	1.3	2.4	6.0	0.7	-1.6	-2.3	0.3	-0.7	-1.5	1.6	-0.9	-2.4	-2.1	-1.2
Peak expiratory flow (PEF)	0.7	1.7	5.6	-0.1	1.0	-0.5	-0.6	0.5	-2.4	1.7	-0.2	-1.6	-2.1	-1.2
Pulse wave reflection index	0.5	0.6	2.7	-0.5	-1.3	-0.7	-0.4	-1.6	-1.1	0.1	-0.3	0.3	0.3	0.2
Ever highly irritable/argumentative for 2 days	0.7	0.8	4.8	-0.0	-0.5	-0.1	-2.2	-0.7	0.2	1.2	0.6	-0.3	-1.0	0.4
Loud music exposure frequency	0.7	0.7	2.2	0.4	1.3	0.0	0.1	1.5	-0.5	0.7	1.2	-0.3	-1.3	-0.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.5	0.5	0.8	0.1	-0.5	1.2	-0.8	0.4	0.5	-0.1	-0.4	-0.1
Mouth/teeth dental problems: Bleeding gums	2.4	3.1	7.9	0.7	-1.2	-2.8	-2.2	-1.2	-1.8	2.3	-1.4	-1.5	-1.6	-1.6
Blood clot in the leg (DVT)	0.7	0.9	5.5	-1.0	0.7	-0.9	-2.3	-0.6	-0.0	0.4	-0.5	-0.7	-0.3	-0.7
Medication: Paracetamol	0.3	0.4	3.6	0.1	-0.3	-0.0	-0.2	0.2	-0.2	-1.9	-0.5	-0.5	0.2	-0.5
Headache pain in last month	0.2	0.4	2.2	-0.3	0.4	0.2	0.9	0.2	-0.1	-1.5	-0.8	-0.7	0.2	0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.9	0.3	-1.4	0.0	-0.1	-0.1	0.8	0.5	-0.6	0.6	-0.0	-0.5
Glaucoma (self-reported)	2.8	3.3	9.0	1.7	0.6	-1.9	-2.0	-0.5	-1.2	3.0	-1.4	-1.8	-1.8	-2.5
Gout (self-reported)	1.4	2.0	5.3	-1.8	0.0	1.4	0.1	0.1	1.7	-1.4	1.4	1.8	1.1	2.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.4	-0.0	-1.0	0.3	-0.5	-1.6	0.0	-0.9	-0.3	1.1	0.7	0.3
Medication: Amlodipine	0.7	1.0	5.2	-2.3	0.4	0.1	0.8	-1.4	-0.2	-0.1	-1.4	-0.3	0.9	0.3
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.2	0.0	-0.4	-0.8	-1.0	-2.1	-1.6	1.1	-2.0	-0.9	-0.1	-1.1
Birth weight	1.4	3.0	6.6	0.9	-0.4	-2.4	-0.3	0.1	-2.1	2.3	-0.8	-1.6	-2.6	-2.5
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.4	0.7	-0.2	0.2	-1.4	-1.6	0.7	1.2	-0.4	0.1	0.3	0.5
High blood pressure (siblings)	1.2	1.8	7.8	-0.8	-0.1	1.8	2.8	0.5	0.9	-1.4	0.5	1.2	0.9	1.4
Forced vital capacity (FVC), Best measure	0.1	0.5	1.5	-0.9	0.6	0.2	-1.1	-0.2	-1.2	0.9	-0.7	-0.7	-0.5	-0.4
Body fat percentage	0.7	2.9	7.3	-2.7	-1.5	2.1	1.4	-0.5	2.2	-1.5	1.3	1.7	0.8	1.8
Leg fat percentage (right)	1.1	3.9	7.3	-2.7	-1.3	2.6	1.5	-1.2	2.5	-1.7	1.4	2.5	1.0	2.2
Arm fat-free mass (right)	0.2	1.3	5.1	-2.2	2.3	1.2	0.2	0.5	-0.5	-0.5	0.0	0.9	0.9	0.6
Exposure to tobacco smoke outside home	0.8	1.0	5.2	-0.9	2.3	0.3	0.5	1.4	1.0	-0.6	1.1	0.4	0.2	0.6
Comparative body size at age 10	0.7	1.9	6.1	1.0	1.1	-1.1	-0.6	-1.2	-1.9	1.4	-2.5	-0.9	-0.2	-1.7
Number of full brothers	1.1	1.4	5.4	1.0	-2.3	-0.6	-0.9	-2.0	0.8	0.7	0.5	0.9	-1.0	0.7
Worry too long after embarrassment	2.0	3.3	6.7	2.1	-0.1	-1.6	-1.7	-1.8	-1.8	1.1	-2.6	-1.8	-1.5	-2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.4	-0.1	-0.1	-0.6	-0.9	-1.0	0.4	1.2	0.1	-0.3	-1.2	-0.6
Wheeze or whistling in the chest in last year	0.6	1.1	8.3	-0.5	-0.9	0.1	0.7	-2.9	0.2	-0.3	-1.1	-0.0	0.8	0.0
Number of children fathered	0.1	0.1	0.3	-0.6	0.4	-0.3	0.0	-0.1	-0.6	0.5	-0.3	-0.4	0.1	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.4	1.0	-0.8	-0.7	-1.5	-1.1	0.3	1.1	-0.4	-0.4	-0.8	-0.4
Age at first live birth	0.4	0.7	4.8	0.7	1.3	-0.3	0.3	2.2	0.3	-0.2	0.7	-0.2	-0.6	-0.1
Pulse wave peak to peak time	0.5	0.6	1.6	0.2	-0.0	1.2	1.1	1.2	1.2	-0.2	0.7	0.5	-0.1	0.5
Health satisfaction	0.4	0.5	1.7	0.2	-0.0	0.0	-1.3	-0.8	1.3	0.0	0.5	0.2	0.5	0.9
Shortness of breath walking on level ground	0.5	0.5	2.5	-0.5	1.6	0.2	-0.8	0.0	0.1	0.3	0.0	0.3	1.2	1.0
Qualifications: College or University degree	1.2	3.7	12.7	1.8	-1.1	-2.1	-1.4	1.4	-1.3	2.6	-0.2	-2.3	-3.6	-1.6
Eye problems/disorders: None of the above	1.7	2.0	5.1	-1.5	0.5	2.2	0.4	0.6	0.6	-2.0	1.5	1.7	1.0	1.7
Mouth/teeth dental problems: Loose teeth	0.5	0.5	2.3	0.9	0.0	-0.7	1.5	0.4	-1.1	0.5	-0.5	-0.5	0.1	-0.6
Emphysema/chronic bronchitis	1.3	1.4	3.7	-0.9	1.1	1.9	1.1	1.9	0.9	-1.1	1.2	1.0	0.5	0.0
Medication for pain relief, constipation, heartburn	0.2	0.3	1.0	0.6	0.2	0.0	-0.4	-0.6	0.7	1.0	-0.3	0.6	0.8	-0.0
Neck or shoulder pain in last month	1.4	2.0	7.3	-1.0	-1.5	0.2	0.6	-2.7	1.8	-0.5	-0.2	1.2	1.5	1.9
Medication: Blood pressure	0.3	0.6	2.7	0.3	1.6	-0.6	0.0	0.1	-1.2	0.3	-0.1	-1.2	-0.7	-0.2
Angina (self-reported)	0.7	1.0	3.2	-0.8	0.9	1.2	1.8	1.1	0.5	-0.4	1.2	0.4	0.5	1.0
Migraine (self-reported)	0.6	0.7	1.7	1.0	-0.3	0.4	-0.9	1.3	0.8	-0.9	1.1	0.2	0.5	1.1
Medication: Ibuprofen	0.3	0.3	0.7	-0.3	-0.3	0.4	0.3	-0.9	-0.6	-0.6	-0.6	0.0	0.6	0.8
Medication: Allopurinol	0.9	1.2	3.0	-1.5	-0.4	1.3	0.5	-0.1	1.1	-1.3	1.1	1.2	0.2	1.7
Medication: Omeprazole	0.8	0.9	2.7	0.1	-1.6	-1.5	-1.5	-0.1	-0.2	0.6	-0.5	-1.0	-1.0	-0.2
Medication: Seretide 50 evohaler	0.6	0.6	1.8	0.0	-0.2	1.2	-1.3	0.3	0.2	-1.2	0.5	1.4	0.1	0.6
Mean time to correctly identify matches	0.6	1.1	4.7	-2.2	-0.7	-1.1	-0.0	-1.1	-0.2	-0.5	-0.9	-1.3	-0.9	-0.8
Heart disease (mother)	0.3	0.4	2.2	0.1	-0.1	0.3	1.5	-1.0	-0.4	-0.2	0.5	0.7	-0.5	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.8	-0.9	0.9	1.0	1.1	0.4	0.0	-1.4	0.6	0.6	0.9	0.7
Whole body fat mass	0.6	2.6	8.9	-3.0	-0.5	2.3	1.1	-0.1	1.7	-1.4	1.0	1.7	1.0	1.7
Leg fat mass (right)	0.8	3.0	7.1	-2.6	0.0	2.7	1.3	-0.4	1.9	-1.4	1.2	2.2	1.2	2.0
Arm predicted mass (right)	0.3	1.4	5.7	-2.4	2.1	1.3	0.5	0.7	-0.2	-0.5	0.1	1.0	0.9	0.8
Pulse rate, automated reading	0.3	0.8	4.0	0.7	0.9	0.2	0.3	-0.9	0.8	-0.8	-2.0	-0.5	1.1	0.1
Alcohol intake frequency.	1.8	4.2	12.1	-2.3	-0.2	2.0	2.7	0.5	1.4	-3.5	1.4	1.5	2.1	2.5
Comparative height size at age 10	0.2	1.3	4.2	-0.7	-0.7	1.0	-0.3	2.1	1.1	0.0	2.0	0.9	0.1	1.5
Number of full sisters	0.5	0.6	1.8	0.3	0.0	0.9	1.1	-0.7	0.7	-0.4	-0.2	0.8	1.3	0.7
Suffer from ‘nerves’	0.6	1.0	2.1	-1.3	-0.0	1.4	1.5	0.2	1.2	-0.9	0.9	1.0	0.5	0.7
Overall health rating	0.5	1.1	6.8	0.7	-1.3	-1.0	-0.4	-2.6	0.3	-0.0	-0.9	-0.0	-0.5	-0.5
Chest pain or discomfort	0.5	0.7	2.5	-0.6	1.0	0.6	0.7	0.4	0.5	-0.4	0.5	1.1	1.6	1.0
Had major operations	0.9	1.1	3.0	0.1	0.7	1.4	-0.7	0.6	1.1	-0.8	1.0	1.7	1.1	1.2
Age at last live birth	0.3	0.4	1.2	0.8	0.7	-0.0	-0.5	0.8	1.1	-0.1	0.7	0.6	0.3	0.8
Family relationship satisfaction	3.1	3.8	5.4	2.2	-0.9	-2.3	-1.6	-1.6	-1.9	2.2	-1.9	-1.9	-2.3	-2.1
Leg pain on walking	1.4	1.8	6.0	0.6	-2.5	-2.0	-0.9	-1.3	-0.3	1.3	-1.3	-1.3	-0.8	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.3	0.4	-0.4	-0.2	1.1	0.2	-0.5	0.8	-0.6	-0.5	-0.6	-0.4
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.7	1.1	-0.2	0.6	-0.9	1.2	0.1	-0.4	1.1	1.3	0.0	0.4
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.2	-1.5	1.3	1.3	0.1	1.5	0.1	-0.6	1.4	0.7	1.0	1.3
Medication: Aspirin	0.1	0.2	0.5	-0.3	0.2	0.3	0.5	-0.1	-0.3	0.3	0.7	0.1	-0.4	0.6
Supplements: Vitamin C	1.1	1.3	2.9	-0.8	1.3	1.4	1.1	1.0	0.7	-1.7	1.2	1.1	0.9	1.0
Knee pain experienced in last month	1.2	1.8	7.2	0.8	-2.7	-1.1	-1.5	-1.2	0.6	2.2	-0.7	-0.3	-0.9	-0.9
Hypertension (Self-reported)	0.4	1.0	6.6	-1.0	-0.8	-0.4	-1.2	-2.6	-0.2	0.1	-1.0	0.0	0.2	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.6	-0.6	-0.9	-1.3	-0.1	-0.3	-0.2	-0.5	-0.7	-0.7	0.0	-0.4
Illnesses of father: Heart disease	1.5	2.0	5.1	0.1	-0.1	2.1	0.3	1.4	1.6	-1.9	1.7	2.2	0.4	1.5
Illnesses of siblings: Diabetes	0.6	0.7	3.8	-0.1	1.0	0.8	-2.0	-0.8	0.1	-0.1	0.4	0.8	1.0	0.6
Smoking status: Previous	0.5	0.7	1.8	-1.1	-1.4	-0.2	1.2	-1.4	0.9	-0.6	-0.5	0.3	0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.8	-0.1	-1.9	-0.3	-2.0	-0.8	-0.1	-0.0	-0.4	-0.3	-1.0	-0.1
Whole body fat-free mass	0.2	0.9	3.8	-1.8	1.9	1.0	-0.3	0.7	-0.7	0.4	-0.1	0.6	0.6	0.3
Leg fat-free mass (right)	0.1	0.6	1.8	-1.2	1.3	0.5	-0.7	0.3	-0.9	0.8	-0.8	-0.0	0.3	-0.1
Arm fat percentage (left)	0.6	2.2	5.3	-2.3	-1.0	2.1	0.9	-0.8	1.9	-1.3	0.8	1.5	1.2	1.7
Average weekly red wine intake	0.2	0.3	1.5	0.5	-0.1	-0.4	0.3	0.0	-1.2	0.1	-0.5	-0.6	-0.8	-0.7
Handedness (chirality/laterality): Left-handed	1.0	1.1	2.7	-1.6	0.1	0.7	0.1	1.2	1.1	-0.5	1.5	1.6	0.1	1.2
Mood swings	0.1	0.2	1.2	0.1	1.1	-0.0	-0.6	-0.0	-0.1	-0.1	0.6	0.4	0.0	-0.0
Loneliness, isolation	0.8	1.1	4.7	1.6	-1.0	-0.8	2.2	-1.1	0.4	-0.7	0.5	0.6	0.1	0.9
Long-standing illness, disability or infirmity	0.8	1.2	3.5	0.4	-1.9	-0.6	1.8	-1.9	-0.1	0.9	-1.2	0.1	0.0	0.3
Ever had bowel cancer screening	0.6	0.7	3.2	-0.2	0.5	0.8	-0.9	-0.5	-0.4	-1.8	-0.2	0.1	1.6	0.4
Diabetes diagnosed by doctor	0.4	0.7	2.5	0.3	1.6	-1.0	-0.8	0.0	-0.4	0.6	-1.1	-0.9	-0.2	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.0	0.5	0.7	0.1	1.0	1.1	0.3	-0.7	0.3	-0.1	1.4	1.3
Friendships satisfaction	1.1	1.3	3.2	0.8	-0.7	-1.8	-1.5	-0.6	-0.9	0.8	-0.7	-1.6	-1.4	-1.1
Qualifications: nursing, teaching	0.8	1.3	3.2	-0.6	1.5	0.6	0.8	1.6	0.6	-1.2	1.8	1.1	0.3	1.4
Commuting to job workplace: Walk	1.1	1.2	3.2	0.3	0.8	-0.7	-1.3	0.1	-1.2	1.0	-1.0	-1.8	-1.2	-1.3
Eye problems/disorders: Cataract	0.3	0.3	1.7	-0.1	-1.3	-0.9	-0.7	0.2	0.4	0.0	0.1	-0.4	-0.1	0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.8	0.5	-0.5	-1.4	-0.3	-0.7	-0.2	0.9	-1.1	-0.9	-0.4	-0.8
Medication for cholesterol	0.9	1.4	4.9	2.2	1.5	-0.3	0.9	1.2	-1.1	0.5	0.1	-0.9	-1.1	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	2.9	5.3	1.1	1.8	-0.9	0.1	2.3	-2.2	2.1	0.7	-1.5	-2.3	-2.0
Back pain experienced in last month	1.0	1.4	7.7	-0.7	-2.8	-0.5	0.6	-1.8	1.7	-0.4	-0.0	0.1	0.0	0.7
Mineral and other dietary supplements	1.5	2.1	3.9	-1.7	1.6	1.6	1.0	0.7	1.2	-2.0	0.6	0.9	1.9	1.6
Breast cancer (self-reported)	0.5	0.6	3.3	-0.3	-1.8	0.0	0.9	-0.9	0.3	-0.1	0.1	0.3	0.1	1.2
Asthma (self-reported)	0.2	0.5	2.0	0.6	-1.4	0.3	0.7	-1.1	-0.2	-0.1	-0.9	0.4	-0.3	-0.0
Osteoporosis (self-reported)	0.5	0.6	2.3	0.2	-0.1	-0.9	-0.2	-0.7	-1.0	1.5	-0.3	-1.0	-0.8	-0.4
Osteoarthritis (self-reported)	0.7	0.9	4.7	-1.4	-2.2	-0.3	0.8	-1.3	0.2	-0.2	-0.4	0.3	-0.2	-0.2
Medication: Aspirin	0.2	0.2	0.8	-0.2	0.2	0.5	0.3	-0.1	-0.2	0.6	0.9	0.3	-0.4	0.8
Medication: Gliclazide	0.8	0.9	4.0	1.0	1.2	-0.6	1.3	2.0	-0.1	-0.4	0.8	-0.3	-0.0	0.3
Illnesses of father: None of the above (group 1)	0.7	0.8	3.3	-0.6	-0.6	-1.2	1.0	0.3	-1.2	0.2	-0.6	-1.8	-0.6	-0.5
Smoking status: Current	0.5	0.8	3.1	0.7	1.8	-0.3	0.9	1.0	-0.8	0.3	-0.9	-0.9	0.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.3	-0.8	-0.0	-0.2	-0.9	-1.3	-0.1	-0.3	-1.5	-0.8	0.2	-0.4
Whole body water mass	0.2	0.9	3.5	-1.7	1.9	1.0	-0.3	0.7	-0.7	0.4	-0.2	0.6	0.6	0.3
Leg predicted mass (right)	0.1	0.5	1.9	-1.2	1.4	0.5	-0.7	0.3	-0.8	0.8	-0.7	-0.0	0.3	-0.0
Arm fat mass (left)	0.6	2.4	8.5	-2.9	-0.1	2.2	0.9	-0.5	1.5	-1.4	0.5	1.5	1.5	1.8
Number of self-reported non-cancer illnesses	0.7	1.2	5.3	-0.3	-1.4	-1.0	-0.4	-2.3	0.1	0.5	-1.9	-0.6	0.5	-0.1
Average weekly champagne plus white wine intake	0.4	0.6	2.4	-0.7	-0.6	-0.9	0.4	-0.7	0.3	1.5	-0.2	-0.9	-1.0	-0.2
Miserableness	0.5	0.8	1.9	-1.0	1.4	1.2	-0.6	0.5	0.4	-1.3	0.8	0.9	0.6	0.4
Guilty feelings	0.8	1.2	3.2	1.4	1.1	-1.0	-1.1	-0.4	-0.7	0.7	-1.8	-1.2	-0.3	-1.5
Wears glasses or contact lenses	0.2	0.2	0.5	-0.2	-0.7	-0.1	-0.6	0.2	-0.1	-0.0	-0.7	-0.4	-0.5	-0.5
Ever taken oral contraceptive pill	0.9	1.0	3.0	0.9	-0.8	0.6	0.6	0.1	1.2	-0.7	1.7	1.3	-0.4	1.1
Hearing aid user	0.3	0.3	1.1	-0.6	0.1	-0.3	-0.5	-0.7	-1.0	-0.4	-0.7	-0.6	-0.3	-0.6
Mother’s age at death	1.9	2.4	5.9	1.4	0.2	-2.2	0.1	0.4	-1.7	1.5	-1.6	-2.4	-1.3	-1.9
Financial situation satisfaction	1.5	1.8	4.7	2.2	0.1	-1.2	-1.4	-0.3	-1.9	1.2	-0.7	-1.2	-1.6	-1.6
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.5	-1.1	-0.8	0.7	1.0	-0.9	1.2	-1.6	0.4	0.7	0.7	0.9
Commuting to job workplace: Public transport	0.3	0.3	0.7	0.4	0.8	-0.4	0.1	0.1	0.2	0.7	-0.8	-0.8	0.4	-0.6
Eye problems/disorders: Glaucoma	3.4	4.0	7.8	1.2	-0.7	-2.4	-2.6	-1.2	-1.1	2.6	-1.9	-2.4	-1.9	-2.8
Medication: Blood pressure	1.3	2.5	7.0	-2.4	-2.6	0.7	-0.6	-2.3	1.7	-0.7	-0.5	1.2	1.2	1.6
Pain type(s) experienced in last month: Hip pain	2.1	2.6	5.5	-1.7	-0.9	1.8	2.0	-0.2	2.3	-2.3	0.9	1.3	1.0	1.9
Supplements: Fish oil (including cod liver oil)	1.4	1.8	7.1	0.6	-2.7	-1.6	-0.1	-1.8	-0.7	1.2	-0.8	-0.7	-1.5	-1.0
High cholesterol (Self-reported)	0.9	1.7	9.4	-0.9	-2.1	-0.7	-1.4	-3.1	0.1	-0.5	-0.8	-0.0	0.3	0.6
Medication: Bendroflumethiazide	0.7	1.1	3.4	-1.9	-1.8	0.3	-0.9	-1.8	0.3	-0.5	-0.5	0.5	0.2	0.8
Medication: Paracetamol	0.2	0.3	1.6	-0.4	-1.0	-0.1	-0.6	-0.2	-0.1	-1.3	-0.6	-0.3	-0.0	-0.4
Medication: Lisinopril	0.2	0.3	0.6	-0.2	0.5	-0.1	-0.7	-0.3	-0.6	0.8	-0.6	-0.8	0.1	-0.3
Medication: Atorvastatin	0.5	0.7	2.8	-0.6	-1.0	-0.5	-1.4	-1.7	-0.1	0.9	-0.1	-0.2	0.2	0.3
Illnesses of father: High blood pressure	2.1	2.6	8.2	1.2	-2.9	-1.1	-2.2	-2.4	-1.1	1.5	-1.6	-0.1	-0.5	-0.9
Alcohol drinker status: Never	0.7	0.9	3.5	-0.0	0.7	1.3	1.9	0.8	0.5	-0.5	0.6	0.7	1.2	0.7
Ever smoked	0.3	0.4	2.5	-0.1	1.1	-0.1	1.6	0.5	0.3	-0.3	-0.3	-0.4	0.1	-0.6
Basal metabolic rate	0.2	1.0	4.5	-2.1	1.5	1.4	0.0	0.7	-0.2	-0.0	0.2	0.9	0.7	0.7
Leg fat percentage (left)	0.9	3.2	7.7	-2.8	-1.3	2.4	1.3	-1.4	2.2	-1.7	0.8	2.2	1.0	1.7
Arm fat-free mass (left)	0.3	1.3	5.0	-2.2	2.2	1.2	0.4	0.9	-0.7	-0.2	-0.1	0.7	0.8	0.4
Number of operations (self-reported)	0.2	0.3	1.8	1.3	0.4	-0.4	0.0	0.2	-0.7	0.9	0.1	0.2	-0.1	-0.1
Average weekly beer plus cider intake	0.9	1.3	4.2	0.0	-1.3	1.3	1.6	0.2	1.0	-2.0	1.2	1.2	-0.8	0.4
Irritability	0.4	0.6	2.7	-0.5	-0.4	0.3	0.2	-0.6	0.8	-0.1	0.3	1.6	1.4	0.9
Risk taking	0.4	0.6	2.0	-0.8	-0.6	0.5	-0.3	-1.4	0.7	0.5	-0.5	0.3	1.3	0.9
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.6	0.6	1.3	-0.4	0.0	0.2	-0.9	0.6	-0.2	-0.5	0.1	-0.4
Fractured/broken bones in last 5 years	0.6	0.8	3.1	-0.4	1.8	0.6	1.6	1.3	0.5	0.1	-0.1	-0.4	0.2	0.1
Age started oral contraceptive pill	0.5	0.6	2.5	-1.6	0.8	0.5	-0.5	0.2	1.2	-0.6	0.5	-0.0	0.7	0.4
Diastolic blood pressure, automated reading	1.7	5.4	17.1	1.3	-2.0	-1.8	-2.6	-4.1	-2.4	2.4	-3.0	-1.3	-1.1	-1.7
Ever depressed for a whole week	0.3	0.4	1.8	0.4	0.0	0.7	0.4	-0.4	0.4	0.1	-0.0	0.7	1.0	1.3
Unable to work because of sickness or disability	1.1	1.4	3.7	-0.2	-0.1	0.7	1.1	-1.9	1.6	-1.0	0.1	1.5	1.3	1.5
Commuting to job workplace: Cycle	0.4	0.5	2.3	0.4	0.7	0.1	1.4	1.5	-0.3	0.5	0.1	-0.5	-0.3	-0.1
Myopia	1.5	2.2	5.4	1.1	-0.5	-1.3	-1.3	0.9	-1.4	2.2	-0.1	-1.5	-2.3	-1.8
Vascular/heart problems diagnosed by doctor	0.4	1.0	6.4	1.1	1.2	-0.1	0.7	2.5	-0.2	-0.1	0.5	-0.4	-0.3	-0.9
Cholesterol lowering medication	0.7	1.1	6.8	-0.3	-2.6	-0.4	-1.3	-1.6	0.4	-0.1	-0.6	0.2	0.0	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.0	-0.4	-1.0	-1.0	-1.1	1.0	-0.1	0.6	0.2	-0.8	-1.4	-0.1
Pain experienced in last month	1.1	1.9	10.2	0.6	3.2	1.0	-0.7	2.0	-0.8	0.7	1.6	0.5	0.3	0.4
Supplements: Calcium	0.2	0.2	0.7	0.8	0.7	-0.5	0.5	0.5	-0.5	0.7	-0.1	-0.3	-0.0	0.1
Basal cell carcinoma (self-reported)	2.7	3.2	6.9	2.6	-0.2	-2.6	-0.2	0.6	-2.2	1.5	-1.0	-2.2	-2.4	-1.8
Heart attack/myocardial infarction (self-reported)	1.7	2.2	8.1	0.3	-1.9	-1.5	0.1	-0.6	-1.4	1.8	-0.2	-1.6	-2.9	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	4.0	-1.1	0.8	-0.6	-2.0	-0.5	0.2	0.3	-0.3	-0.5	0.1	-0.3
Heart disease (siblings)	2.0	2.4	4.9	-1.6	-1.0	1.1	1.6	-2.0	2.2	-1.6	1.0	1.7	0.7	1.9
Alcohol drinker status: Previous	0.5	0.5	3.6	0.3	0.5	-0.5	1.9	-0.2	-0.1	-0.8	-0.6	-0.3	0.5	0.4
Pack years of smoking	1.0	1.5	2.8	-1.5	1.7	1.4	0.7	0.8	1.7	-1.2	0.6	1.3	1.2	0.7
Impedance of whole body	0.5	2.7	9.8	1.1	-3.1	-1.0	1.4	1.7	0.8	0.6	2.4	-0.4	-2.5	0.2
Leg fat mass (left)	0.7	2.6	6.9	-2.6	-0.0	2.5	1.2	-0.5	1.8	-1.4	0.8	2.0	1.3	1.8
Arm predicted mass (left)	0.2	1.2	4.7	-2.2	1.9	1.3	0.5	0.8	-0.3	-0.5	0.1	0.9	0.8	0.6