Hub : Genes

UMPS

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1630 0.0340 6.6e-15 0.182 0.160 0.191 0.197 0.190 1.3e-21 5.6e-19 1.1e-22 1.7e-23 1.3e-22
2 GTEx Cells Transformed fibroblasts 0.1050 0.0380 1.4e-03 0.025 NA 0.013 NA 0.014 5.2e-03 NA 3.6e-02 NA 2.8e-02
3 GTEx Esophagus Mucosa 0.1220 0.0420 6.2e-04 0.119 NA 0.118 NA 0.111 2.5e-08 NA 2.8e-08 NA 7.8e-08
4 GTEx Lung 0.1391 0.0452 1.4e-03 -0.003 NA 0.017 NA 0.005 7.5e-01 NA 1.6e-02 NA 1.2e-01
5 GTEx Nerve Tibial 0.1279 0.0530 6.9e-03 0.013 NA 0.104 NA 0.043 4.1e-02 NA 7.9e-08 NA 5.2e-04
6 GTEx Skin Sun Exposed Lower leg 0.1090 0.0380 1.4e-03 0.030 NA 0.012 NA 0.039 1.5e-03 NA 3.4e-02 NA 3.6e-04
7 YFS Blood 0.0194 0.0075 5.5e-04 0.008 0.008 0.006 0.009 0.005 8.6e-04 8.3e-04 2.5e-03 4.3e-04 7.8e-03
8 TCGA Brain Lower Grade Glioma 0.0559 0.0273 4.5e-04 0.001 0.032 0.026 NA 0.018 2.1e-01 1.4e-04 5.0e-04 NA 3.8e-03
9 TCGA Pancreatic Adenocarcinoma 0.1540 0.0860 4.1e-03 0.083 0.033 0.028 NA 0.056 2.3e-04 1.5e-02 2.4e-02 NA 2.3e-03
10 TCGA Testicular Germ Cell Tumors 0.1120 0.0610 3.7e-03 0.084 0.058 0.090 NA 0.087 6.9e-04 4.3e-03 4.5e-04 NA 5.3e-04
11 TCGA Thyroid Carcinoma 0.0410 0.0220 7.5e-04 0.044 0.034 0.033 NA 0.044 3.8e-05 2.8e-04 3.3e-04 NA 3.8e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.4 0.6 1.8 1.0 -0.3 -0.6 1.4 0.1 -0.5 0.4 -1.0 -1.1 0.5 0.3
Bipolar Disorder or Schizophrenia 0.7 1.8 7.8 -1.0 1.2 1.3 0.4 -0.5 1.4 -1.6 -0.5 0.5 2.8 1.4
Depressed Affect (Nagel 2018) 0.1 0.3 1.5 0.3 1.2 -0.7 0.3 -0.0 0.1 -0.7 0.5 0.0 0.5 -0.1
Depression (Nagel 2018) 0.2 0.3 0.9 -0.6 -0.0 -0.5 -0.9 -0.1 0.6 -0.3 0.9 -0.1 -0.5 -0.5
Intelligence (Savage-Jansen 2018) 0.9 2.6 5.0 1.7 -1.2 -2.2 -1.6 0.2 -1.8 1.6 -1.4 -2.2 -1.7 -1.4
Neuroticism (Nagel 2018) 0.5 1.3 3.1 1.7 0.4 -1.5 -0.3 -1.0 -0.9 0.7 -1.8 -1.1 -0.1 -1.4
Schizophrenia (2018) 1.8 3.7 10.2 -2.4 1.7 2.2 -0.5 -0.9 2.2 -2.4 0.2 1.6 3.2 1.6
Schizophrenia vs Biploar Disorder 0.8 1.1 4.0 -0.4 0.9 2.0 -1.3 0.2 1.2 -1.1 0.8 1.1 0.2 0.7
Worry (Nagel 2018) 0.0 0.1 0.2 0.3 -0.1 0.2 0.5 -0.1 0.3 -0.3 -0.4 0.4 0.4 -0.1
Alzheimer’s Disease (in mother) 0.5 0.6 1.6 0.4 0.1 -0.6 -0.2 1.2 -1.1 0.9 0.8 -0.6 -1.2 -0.6
Alzheimer’s Disease (in father) 0.7 0.7 1.4 -0.7 -1.2 0.7 1.1 0.8 0.6 -0.5 1.1 1.1 -0.5 0.7
Alzheimer’s Disease (including proxy) 0.4 0.5 1.4 -0.3 -0.7 -0.1 1.1 1.2 -0.3 0.4 1.0 0.0 -1.1 0.1
Crohns Disease (2017) 1.0 2.2 4.4 -0.2 -1.1 -1.5 -1.6 -0.9 -1.6 2.1 -1.8 -1.7 -1.0 -1.8
Irritable Bowel Disease (IBD) 0.8 2.0 7.7 0.8 -1.1 -1.3 -1.2 -1.4 -1.4 2.8 -1.4 -1.1 -0.9 -1.4
Ulcerative Colitis (UC) 0.5 0.9 4.4 0.6 -1.3 -0.2 -0.7 -1.5 0.0 2.1 -0.1 0.4 -0.4 -0.1
Major Depression (MDD) 0.6 0.8 2.5 0.0 0.1 -1.6 -1.0 -0.6 -1.1 0.7 -1.3 -1.0 0.0 -0.5
Reaction Time 0.5 0.9 4.8 -2.2 -0.8 -0.1 0.8 -1.0 0.8 -1.3 0.1 -0.1 -0.5 0.4
Verbal and Numeric Reasoning (VNR) 1.5 3.7 7.5 1.5 -1.6 -2.4 -1.4 -0.1 -2.0 2.2 -2.0 -2.7 -2.0 -1.9
Breast Cancer 0.3 0.8 3.4 0.9 0.5 -0.7 -0.4 0.6 -1.8 0.2 -1.1 -0.9 -0.6 -1.2
Ovarian Cancer 0.2 0.3 1.7 0.6 0.4 -0.2 1.3 -0.1 0.6 0.8 -0.1 -0.2 0.1 0.4
Prostate Cancer 1.0 1.4 2.8 1.7 -1.5 -1.2 0.3 -1.2 0.3 1.3 -1.4 -1.1 -1.0 -1.2
Age at First Birth 1.4 2.1 4.5 0.9 -0.8 -1.5 -0.1 -0.5 -2.0 1.9 -2.1 -1.5 -1.4 -1.5
Bipolar Disorder (2011) 0.1 0.1 0.2 -0.1 0.2 -0.2 -0.4 0.1 -0.5 0.5 -0.2 -0.2 0.2 -0.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.5 0.0 -0.5 -0.2 -0.1 -0.2 -0.6 -0.1 -0.2 -0.7 0.0 -0.2
Coronary Artery Disease (CAD) 0.5 0.6 2.0 -0.8 -0.4 0.1 0.6 -0.4 0.7 -0.1 1.4 1.2 0.0 1.0
Crohns Disease (2012) 2.2 3.5 7.8 0.1 -0.8 -2.4 -1.7 -1.2 -1.8 2.8 -2.3 -2.4 -1.1 -2.1
Mean Putamen Volume 0.6 0.7 3.1 0.8 -0.6 -1.2 -0.9 -0.2 -1.8 0.3 -0.9 -0.6 -0.2 -0.5
Fasting Glucose 0.6 0.7 3.7 -0.2 1.9 -0.5 0.8 -0.4 -0.7 0.7 -0.6 -1.4 0.4 -0.3
HbA1C 1.4 1.5 3.9 0.7 1.1 -0.9 -1.9 -1.2 -1.1 1.4 -0.9 -0.7 -1.0 -2.0
HDL Cholesterol 0.4 0.6 4.1 1.2 0.9 -0.2 0.0 -0.3 -0.0 2.0 -0.6 -0.2 -0.1 0.0
LDL Cholesterol 1.0 1.6 4.9 2.2 -1.5 -1.5 0.4 0.4 -1.4 1.0 -0.4 -1.5 -1.6 -0.8
Lupus 0.2 0.3 0.7 -0.9 -0.6 0.6 0.7 0.2 0.7 -0.5 0.4 -0.0 -0.2 0.5
Neuroticism (2016) 0.9 1.3 2.9 -0.1 -1.5 -1.4 -1.7 -1.7 -0.2 1.0 -1.7 -0.9 -0.2 -0.4
Primary Biliary Cirrhosis 0.6 0.9 3.4 -1.6 0.6 0.6 1.9 1.0 0.5 -0.8 0.7 -0.1 0.7 0.1
Rheumatoid Arthritis 1.2 1.6 8.4 -1.1 -0.1 1.4 1.6 -0.1 2.9 -1.0 0.2 0.5 0.9 1.2
Schizophrenia (2014) 1.8 3.9 8.5 -2.4 1.6 2.6 1.4 0.2 1.8 -2.8 0.3 1.5 2.9 1.9
Triglycerides 0.6 1.0 7.8 0.1 -2.8 -0.6 -0.4 -0.5 -0.2 -0.2 -0.7 -0.3 -0.8 -0.8
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.7 0.3 0.6 -0.4 0.4 0.0 -0.3 -0.1 -0.8 -0.0 0.8 -0.3
Ulcerative Colitis 2.1 3.0 9.3 2.0 -1.3 -1.7 -1.1 -2.0 -1.5 3.1 -2.0 -0.9 -1.0 -1.5
Blood Eosinophil Count 0.1 0.6 1.8 0.6 -0.9 0.9 0.9 -1.1 0.3 -0.8 0.4 0.5 0.4 1.3
Blood Platelet Count 0.5 5.5 31.2 1.5 -0.1 -0.9 5.6 4.2 -0.9 -1.7 1.1 -0.4 -1.9 -0.4
Blood Red Count 0.2 2.3 7.1 0.3 -0.3 -2.4 1.8 1.4 -2.7 0.1 -0.8 -2.2 -0.9 -0.9
Blood White Count 0.5 3.9 9.7 -1.6 -1.6 2.5 1.4 -0.1 3.1 -1.7 1.7 2.1 1.4 2.9
Heel T-Score 2.1 16.6 28.3 4.1 -2.8 -4.8 -0.1 -0.5 -4.6 5.3 -3.6 -4.8 -4.8 -5.0
BMI 0.3 1.7 4.9 -2.2 -0.4 1.6 0.7 -1.3 1.0 -1.3 -0.4 0.8 1.6 1.5
Height 0.2 3.6 14.9 -0.8 -2.1 -0.6 0.2 3.2 -0.9 2.0 1.7 -0.6 -3.9 -1.1
Waist Hip Ratio (WHR) 0.2 0.7 4.4 -0.1 1.2 -0.0 -0.1 -0.2 -0.2 0.0 -1.2 -0.6 2.1 0.1
Systolic Blood Pressure 2.0 10.2 19.4 1.5 -3.7 -3.5 -3.5 -4.4 -2.7 4.3 -3.5 -2.2 -2.3 -2.1
Smoking Status 0.2 0.5 2.0 -0.9 0.1 0.5 1.4 0.1 0.6 -0.4 -0.7 0.2 1.3 -0.3
Allergy or Eczema 0.7 1.8 5.0 -0.3 -1.6 -1.0 0.5 -1.0 -0.7 -0.1 -1.6 -2.1 -2.2 -1.7
Cardiovascular Disease 0.4 1.2 8.3 -0.4 -1.1 -0.6 -0.6 -2.9 -0.3 0.3 -1.0 0.2 0.3 1.0
Hypothyroidism (self reported) 0.2 0.6 2.0 -0.2 -0.2 0.5 -0.1 -1.1 -0.3 -1.4 0.0 1.0 1.0 0.7
Respiratory disease 0.3 0.7 1.3 0.2 -1.1 1.0 1.1 -0.7 0.9 -0.7 -0.2 1.1 0.6 0.8
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.9 0.5 1.7 -1.3 -1.5 0.2 -0.6 1.2 -0.8 -1.4 -0.2 -0.1
Lung FEV1/FVC ratio 1.1 5.6 15.2 1.2 0.9 -3.0 -0.2 -0.7 -2.9 2.2 -2.4 -3.9 -3.0 -2.7
Lung FVC 0.4 2.1 7.2 0.4 2.7 -0.5 -0.9 -1.4 -1.6 -0.1 -2.3 -1.4 1.3 -1.3
Neuroticism 0.1 0.3 1.2 0.9 -0.4 -0.2 -1.1 -0.3 0.4 0.1 -0.2 0.1 -0.0 -0.8
Chronotype (morning person) 0.6 1.4 3.3 -1.1 -1.3 0.9 1.4 -0.5 0.6 -1.4 1.0 1.8 1.1 1.3
Hair Pigment 0.1 3.6 9.2 1.5 1.9 -2.4 -0.9 -1.0 -1.3 1.9 -3.0 -2.8 0.3 -2.0
Tanning 0.1 0.8 3.0 0.0 -1.7 0.4 0.7 -1.4 0.6 -0.6 -0.3 1.5 0.5 0.8
Hand grip strength (left) 1.1 3.0 8.1 -1.1 0.6 2.8 1.5 2.1 0.6 -0.1 2.3 2.7 0.8 1.7
Number of treatments/medications taken 0.6 1.1 4.7 -0.9 -1.6 0.2 -1.2 -2.2 0.7 -0.7 -0.5 0.4 0.7 1.0
Average weekly spirits intake 4.0 4.9 14.4 2.9 0.2 -2.1 -0.4 0.7 -2.4 3.8 -1.1 -2.6 -2.8 -2.2
Sensitivity / hurt feelings 0.4 0.7 3.6 1.9 0.4 -0.6 1.0 -0.6 -0.4 0.8 -0.9 -0.8 -0.2 -0.4
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.1 0.6 -1.0 -0.8 0.2 -1.0 0.2 0.3 -0.4 -0.5 -1.1 -0.6
Hearing difficulty/problems: Yes 0.5 0.7 3.4 -0.2 0.4 0.2 -0.3 -1.4 0.2 0.1 -1.3 0.0 1.8 0.6
Relative age of first facial hair 2.1 4.4 9.8 3.1 0.4 -2.2 -1.9 -1.1 -3.0 2.2 -1.6 -2.0 -1.6 -2.4
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 2.5 0.5 -1.1 -0.6 1.6 -0.9 -0.8 0.8 -1.0 -0.6 -0.2 -0.4
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.5 -1.2 0.1 -0.5 -0.8 -0.5 0.6 0.5 -0.2 -0.6 0.8 0.2
Ever had hysterectomy (womb removed) 0.6 0.6 2.5 -0.5 -0.2 0.6 0.6 -0.9 0.9 -0.7 -0.3 0.6 1.6 1.0
Systolic blood pressure, automated reading 1.6 4.6 12.9 -0.3 -3.1 -1.8 -2.8 -3.6 -1.0 3.0 -2.1 -0.7 -1.3 -0.9
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.8 1.0 1.6 -0.7 0.7 0.9 -1.7 0.7 -0.6 -0.8 -0.2 -0.4
Angina 0.6 0.8 3.3 -0.6 0.7 1.0 1.8 0.9 0.3 -0.3 1.1 0.3 0.5 0.9
Medication for hormone replacement therapy 0.4 0.4 1.1 -0.2 0.5 -0.9 -0.6 0.1 -0.5 0.8 -0.6 -1.0 0.7 0.6
Vitamin and mineral supplements 0.7 1.0 4.0 -0.5 2.0 0.6 1.1 1.6 0.5 -0.2 0.5 0.4 1.3 0.6
Supplements: Zinc 0.6 0.7 2.5 0.2 1.6 0.6 -0.1 1.6 0.1 0.1 1.2 0.6 -0.4 0.4
Medication: Co-codamol 1.5 1.7 4.5 -0.8 -0.9 1.2 1.1 -0.8 2.1 -1.6 0.4 1.7 1.6 1.1
Medication: Metformin 0.1 0.1 0.4 -0.6 0.1 -0.3 -0.4 -0.2 0.3 0.4 -0.4 -0.1 0.0 -0.0
Diabetes (father) 6.1 7.5 12.8 3.6 1.4 -3.1 -3.3 -0.9 -3.3 3.5 -1.9 -2.1 -2.2 -3.2
Diabetes (mother) 0.4 0.5 1.5 -0.6 -0.3 0.5 -0.9 0.4 0.6 -0.4 0.9 1.1 0.5 1.2
Severe depression (siblings) 0.5 0.6 2.0 -0.7 -1.1 -0.2 0.4 -0.8 1.4 0.3 -0.6 -0.1 1.0 0.8
Pack years adult smoking proportion 1.1 1.6 3.4 -1.3 1.8 1.4 1.0 1.3 1.8 -1.2 0.9 1.2 0.9 0.6
Impedance of leg (right) 0.7 3.4 12.7 0.2 -2.3 0.5 2.5 1.7 1.8 -0.7 3.6 1.3 -1.6 1.7
Leg fat-free mass (left) 0.1 0.5 1.6 -1.2 1.3 0.7 -0.5 0.3 -0.5 0.8 -0.4 0.3 0.3 0.3
Trunk fat percentage 0.6 2.6 7.2 -2.7 -1.6 1.8 1.3 -0.1 2.1 -1.3 1.6 1.4 0.6 1.7
Hand grip strength (right) 0.9 2.4 7.5 -0.8 0.6 2.7 0.9 2.1 1.0 0.0 1.9 2.4 0.5 1.3
Townsend deprivation index at recruitment 0.4 0.6 3.1 -0.2 0.0 -0.2 0.4 -1.7 0.6 -0.8 -1.3 -0.6 0.4 -0.1
Current tobacco smoking 0.6 0.9 4.4 0.5 2.1 -0.2 1.4 1.2 -0.4 0.1 -0.6 -0.9 0.5 -0.9
Average weekly fortified wine intake 1.4 1.6 3.4 1.7 -1.2 -1.0 -0.4 0.6 -1.5 1.0 -1.0 -0.9 -1.8 -1.8
Maternal smoking around birth 1.3 1.8 7.6 0.5 2.1 1.4 -0.6 -0.2 0.8 -1.8 -0.9 -0.1 2.8 0.9
Fed-up feelings 0.3 0.5 3.1 -0.2 1.8 0.1 0.1 0.6 0.6 -0.4 0.8 0.1 0.6 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 1.6 -0.4 -0.1 0.0 -1.3 -0.7 0.1 -0.5 -0.1 -0.1 -0.1 -0.4
Relative age voice broke 1.6 2.4 7.7 2.8 0.1 -2.0 -1.5 -0.6 -2.1 1.7 -0.8 -0.7 -1.0 -1.6
Taking other prescription medications 0.4 0.6 2.0 1.0 -1.4 -0.4 -0.4 -1.3 -0.2 0.1 -1.3 -0.4 0.0 0.1
Age when periods started (menarche) 1.2 2.8 6.7 2.6 0.7 -1.2 -2.2 0.4 -1.4 2.3 -1.2 -1.8 -1.3 -1.9
Bilateral oophorectomy (both ovaries removed) 2.0 2.3 5.8 -1.9 0.8 1.4 1.3 0.2 1.7 -2.0 0.4 0.9 2.4 2.0
Heel bone mineral density (BMD) T-score, automated (left) 2.0 4.5 8.3 2.5 -2.4 -2.7 -0.9 -1.1 -1.7 2.1 -1.4 -2.4 -2.9 -2.3
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.5 -0.1 -0.2 -0.0 0.6 0.4 0.6 0.1 0.6 0.6 0.4 0.7
Qualifications: CSEs or equivalent 0.3 0.4 2.0 -0.4 -0.3 -0.1 -1.4 -1.2 0.4 -0.7 -0.3 -0.1 0.5 0.1
Serious illness, injury or assault to yourself 1.1 1.4 2.8 1.0 -1.7 -1.4 -0.7 -0.4 -0.9 1.5 -1.1 -1.1 -1.3 -1.3
High blood pressure 0.4 1.2 7.3 -1.1 -1.0 0.1 -1.1 -2.7 0.3 -0.0 -1.0 0.5 0.6 0.7
Hayfever, allergic rhinitis or eczema 0.8 1.7 4.6 -0.6 -1.7 -0.7 1.5 -0.3 -0.4 0.2 -1.2 -1.9 -2.1 -1.7
Multivitamins +/- minerals 1.1 1.4 4.1 1.5 -2.0 -0.9 -1.5 -1.1 -0.9 1.1 -0.1 -0.3 -1.5 -0.6
Stomach or abdominal pain in last month 0.4 0.5 3.1 0.5 -1.8 -0.3 0.7 -0.7 -0.2 -0.7 -0.1 -0.2 -0.3 0.4
Supplements: Glucosamine 0.9 1.1 2.6 1.2 -1.2 -0.4 0.1 -1.4 -0.9 1.0 -1.6 -0.4 -1.1 -1.3
Diverticular disease/diverticulitis (self-reported) 1.5 1.7 7.8 -1.3 0.0 1.3 1.8 -0.4 -0.5 -2.8 0.3 1.2 1.3 0.9
Medication: Atenolol 1.4 1.8 4.3 -1.6 0.5 1.0 1.4 -0.8 1.4 -1.2 0.9 0.9 1.9 2.1
Medication: Levothyroxine sodium 0.3 0.5 1.7 0.4 -0.3 0.8 -0.1 -0.2 -0.1 -1.3 0.3 1.1 0.9 0.6
Sitting height 0.2 1.5 4.6 -1.8 0.4 0.5 1.2 2.1 -0.2 0.3 1.8 0.9 -0.1 1.4
Chronic bronchitis/emphysema (father) 1.4 1.6 3.8 -0.3 1.4 2.0 0.7 0.6 2.0 -1.4 1.2 1.7 0.8 0.2
High blood pressure (mother) 0.6 0.8 1.7 1.3 -0.9 -1.1 1.3 -0.9 -0.8 1.0 -0.9 0.1 -0.2 0.5
Body mass index (BMI) 0.9 3.7 9.9 -3.1 0.8 2.7 0.8 -1.2 1.7 -2.3 0.3 2.1 2.3 1.8
Impedance of leg (left) 0.6 2.8 9.5 0.3 -2.3 0.3 2.3 1.5 1.6 -0.8 3.1 1.1 -1.7 1.1
Leg predicted mass (left) 0.1 0.5 1.7 -1.3 1.1 0.7 -0.6 0.2 -0.6 0.8 -0.4 0.3 0.3 0.3
Trunk fat mass 0.6 2.4 9.2 -3.0 -0.8 2.0 1.1 0.2 1.7 -1.1 1.4 1.5 0.8 1.7
Waist circumference 0.5 1.9 6.2 -2.5 0.3 1.9 0.8 -0.5 1.1 -1.5 -0.4 1.1 1.9 1.0
Number of incorrect matches in round 0.8 1.4 3.2 -1.3 1.2 1.7 0.3 -0.9 1.1 -1.1 -0.0 1.4 1.8 0.9
Past tobacco smoking 0.2 0.3 1.4 0.5 0.1 0.2 -1.2 0.5 -0.3 0.4 0.6 0.2 -0.4 0.5
Alcohol usually taken with meals 0.6 1.0 3.7 -1.9 -0.6 0.7 -1.0 0.0 0.6 -1.3 0.6 0.6 1.0 1.1
Nervous feelings 0.3 0.6 1.7 -0.4 0.4 0.7 0.7 0.2 0.8 -1.2 0.0 1.1 1.3 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 2.0 1.1 0.9 0.4 0.7 1.4 0.4 -1.3 -0.1 -0.1 -0.5 -0.7
Hearing difficulty/problems with background noise 1.1 1.8 7.0 -0.4 1.8 1.4 -0.5 -0.3 1.1 -1.5 -0.2 1.5 2.6 1.3
Hair/balding pattern: Pattern 2 0.4 0.5 2.5 1.0 -0.4 0.1 -1.6 -0.9 0.0 0.3 -0.7 -0.0 -0.3 -0.2
Had menopause 0.8 1.0 3.4 -0.9 -0.6 -0.7 -1.9 -1.0 -0.6 -0.1 -1.6 -0.7 1.1 -0.2
Had other major operations 0.9 1.1 3.0 0.8 -1.3 -1.1 0.9 -1.7 -0.9 1.1 -1.4 -0.3 -0.7 -0.9
Forced vital capacity (FVC) 0.2 0.9 3.7 -0.2 0.8 -0.2 -0.8 -0.1 -1.9 1.1 -0.9 -1.1 -0.8 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.2 5.0 2.2 -1.3 -1.5 -0.2 -0.6 -1.2 1.3 -0.9 -1.6 -2.2 -1.9
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.8 0.2 -0.5 -0.9 0.1 -1.2 -0.8 1.4 -1.2 -1.0 -0.2 -0.6
Qualifications: None of the above 0.8 1.7 3.6 -1.7 -0.0 1.7 0.4 -1.5 1.4 -1.9 0.6 1.6 1.4 0.8
Financial difficulties in last 2 years 0.4 0.6 3.6 1.0 -0.8 0.3 -0.2 -1.9 0.6 0.0 -0.6 0.0 -0.0 -0.1
Mouth/teeth dental problems 0.6 0.9 5.1 1.1 2.3 0.9 0.5 1.2 -0.3 -0.9 0.3 0.2 0.2 0.0
Heart attack 1.9 2.4 8.9 0.4 -2.1 -1.6 0.5 -0.5 -1.4 1.9 -0.3 -1.7 -3.0 -1.2
Allergy 0.3 0.7 1.8 1.1 0.8 -0.6 -1.3 -0.2 -0.8 0.9 0.0 0.3 1.2 0.5
Pain all over the body in last month 0.4 0.4 1.5 0.7 -1.2 -0.3 1.0 -0.8 0.2 0.1 0.4 0.6 -0.4 0.5
Diabetes (self-reported) 0.5 0.7 2.7 -0.2 1.6 -0.9 -0.9 -0.2 -0.7 0.2 -1.2 -1.0 0.3 -0.4
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 4.0 0.5 -1.4 -1.1 -0.3 -2.0 -0.7 1.5 -1.5 -0.8 -1.6 -1.9
Medication: Ramipril 0.5 0.6 1.8 -1.3 0.5 0.6 -0.2 0.9 0.9 -0.6 1.3 0.6 -0.3 0.4
Medication: Simvastatin 0.6 0.9 4.1 -1.1 -0.8 0.8 -0.0 -0.3 1.1 -2.0 0.9 0.8 0.1 1.0
Fluid intelligence score 2.3 4.7 11.2 1.7 -0.5 -2.7 -0.4 0.4 -2.8 2.9 -2.0 -3.4 -2.4 -2.0
Illnesses of siblings 2.1 3.0 6.9 1.2 0.9 -1.9 -1.8 1.1 -1.9 1.6 -0.6 -2.3 -2.0 -2.6
Neuroticism score 0.2 0.4 0.9 0.4 0.9 0.6 -0.3 -0.2 0.7 -0.7 0.1 0.9 0.9 0.0
Weight 0.5 2.4 9.5 -3.1 0.6 2.2 0.8 0.5 1.1 -1.1 1.1 1.6 1.1 1.7
Impedance of arm (right) 0.8 3.7 10.1 1.9 -3.2 -1.7 0.1 1.9 0.1 2.4 1.8 -1.4 -3.0 -0.6
Arm fat percentage (right) 0.5 1.8 4.5 -2.1 -0.9 1.9 0.9 -0.6 1.7 -0.9 0.7 1.4 1.1 1.6
Trunk fat-free mass 0.2 1.3 5.2 -2.0 2.3 1.3 -0.2 1.1 -0.6 0.1 0.3 0.9 0.8 0.6
Hip circumference 0.9 4.0 9.7 -3.1 -0.7 2.7 1.9 -0.0 2.0 -1.9 1.5 2.5 1.3 2.4
Time employed in main current job 0.6 0.7 2.7 -0.2 0.6 -0.8 -0.3 -0.0 -1.3 -0.1 -1.7 -1.2 0.8 -0.3
Alcohol intake versus 10 years previously 0.8 1.2 2.6 -1.5 -0.2 1.6 0.3 -0.6 1.4 -1.6 0.9 1.1 0.6 0.9
Father’s age at death 0.1 0.1 0.5 -0.4 0.1 -0.5 -0.7 0.3 -0.0 0.2 0.5 -0.1 -0.2 0.1
Worrier / anxious feelings 0.2 0.4 1.0 0.9 -0.8 -0.3 -0.5 -0.1 -0.1 0.5 -0.1 0.1 -0.9 -1.0
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.4 -0.4 -0.5 -0.0 0.5 -0.2 0.1 -0.6 0.4 -0.1 -0.2 0.2
Falls in the last year 1.1 1.5 5.7 2.4 0.1 -1.0 -1.3 -0.9 -0.0 2.0 -0.7 -0.6 -0.9 -1.2
Hair/balding pattern: Pattern 3 0.3 0.5 2.4 0.6 -0.4 -0.1 -0.7 -1.5 -0.1 -0.5 -1.1 0.5 0.8 -0.2
Number of live births 0.4 0.5 1.4 -0.1 -0.8 0.4 -0.1 -0.7 0.7 -1.1 0.4 0.6 0.9 1.2
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 6.1 0.2 0.7 -1.0 -1.0 -0.4 -2.5 1.6 -1.3 -2.0 -1.8 -1.6
Pulse rate 0.3 0.4 1.3 0.6 1.1 0.2 0.7 0.6 0.8 -0.2 -0.1 0.3 1.0 0.7
Happiness 1.2 1.4 4.8 1.6 -0.8 -1.5 -1.4 0.1 -0.8 0.7 0.3 -1.3 -2.2 -0.8
Noisy workplace 1.8 2.2 5.5 -0.2 1.2 2.0 0.6 0.5 2.3 -0.4 1.5 2.1 1.7 1.6
Qualifications: A levels/AS levels or equivalent 0.9 2.0 7.0 1.1 -1.3 -1.3 -2.0 0.3 -1.2 1.6 0.2 -0.8 -2.6 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 6.1 2.5 -0.4 -0.9 0.4 0.2 -1.2 0.5 -0.5 -0.4 -1.2 -0.9
Mouth/teeth dental problems: Dentures 0.9 1.5 5.1 -2.2 -2.1 1.3 1.4 0.2 1.3 -0.4 0.7 0.8 0.3 0.8
Asthma 0.2 0.4 1.6 0.4 -1.3 0.4 0.7 -1.1 -0.1 -0.2 -0.9 0.3 -0.3 0.0
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.3 -0.1 0.3 0.7 0.1 -0.7 -0.1 -1.0 -0.3 0.1 1.0 1.1
Medication: Cholesterol lowering 1.5 2.4 7.1 -2.2 0.6 1.5 1.0 -0.3 1.3 -2.7 1.5 0.8 1.4 1.9
Depression (self-reported) 1.1 1.3 3.3 0.1 -0.4 -1.6 -0.6 -1.0 -0.2 1.8 -1.0 -1.8 -1.4 -0.9
Medication: Lansoprazole 0.3 0.4 1.1 -0.6 -0.5 0.3 0.5 -0.9 0.9 -1.1 -0.0 0.1 0.6 0.4
Prospective memory result 4.8 5.9 11.9 -2.9 1.0 2.2 3.4 0.6 2.9 -3.4 1.5 2.4 2.6 2.0
Lung cancer (father) 1.0 1.2 3.9 0.1 2.0 1.8 -0.6 1.2 0.1 -0.3 0.7 1.1 1.3 0.5
Illnesses of mother 0.2 0.3 1.4 -0.7 -0.3 0.1 -0.3 1.2 0.7 -0.6 0.1 -0.3 0.2 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.2 -0.8 0.4 -0.2 -1.0 -0.2 -1.5 0.9 -0.7 -1.4 -1.3 -0.8
Pulse wave Arterial Stiffness index 0.7 0.8 2.0 -0.1 -0.3 -1.4 -1.1 -1.3 -1.3 0.6 -0.8 -0.6 -0.2 -0.7
Impedance of arm (left) 0.7 3.1 12.0 1.7 -3.5 -1.5 0.1 1.4 0.4 1.8 1.7 -1.2 -2.6 -0.3
Arm fat mass (right) 0.5 2.2 7.3 -2.7 0.1 2.2 1.0 -0.3 1.5 -1.2 0.7 1.5 1.4 1.8
Trunk predicted mass 0.2 1.3 5.6 -2.0 2.4 1.3 -0.3 1.1 -0.7 0.1 0.2 0.9 0.8 0.5
Standing height 0.3 2.8 14.7 -0.6 -0.2 -0.4 0.2 3.8 -1.1 2.2 2.2 -0.5 -2.1 0.1
Length of working week for main job 0.5 0.6 1.3 0.1 0.9 -1.1 0.4 1.0 -0.8 0.2 -0.7 -1.1 -0.1 -0.9
Exposure to tobacco smoke at home 2.8 3.1 6.6 -1.6 2.4 2.1 0.7 1.0 1.7 -2.6 0.8 1.4 2.1 1.8
Breastfed as a baby 0.2 0.3 1.0 -0.4 0.2 0.0 -0.1 1.0 -1.0 0.8 -0.2 -0.3 -0.0 -0.1
Tense / ‘highly strung’ 0.4 0.6 1.3 -0.9 -1.1 0.8 -0.2 0.2 0.8 -1.1 0.7 0.9 0.1 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 4.1 -0.1 1.3 1.9 0.7 2.0 1.6 -0.8 1.6 1.4 1.0 1.1
Hair/balding pattern: Pattern 4 1.0 2.5 4.6 1.3 1.3 -1.4 1.7 2.1 -1.7 2.1 -0.6 -1.7 -1.2 -1.8
Birth weight of first child 1.3 2.4 6.0 0.7 -1.6 -2.3 0.3 -0.7 -1.5 1.6 -0.9 -2.4 -2.1 -1.2
Peak expiratory flow (PEF) 0.7 1.7 5.6 -0.1 1.0 -0.5 -0.6 0.5 -2.4 1.7 -0.2 -1.6 -2.1 -1.2
Pulse wave reflection index 0.5 0.6 2.7 -0.5 -1.3 -0.7 -0.4 -1.6 -1.1 0.1 -0.3 0.3 0.3 0.2
Ever highly irritable/argumentative for 2 days 0.7 0.8 4.8 -0.0 -0.5 -0.1 -2.2 -0.7 0.2 1.2 0.6 -0.3 -1.0 0.4
Loud music exposure frequency 0.7 0.7 2.2 0.4 1.3 0.0 0.1 1.5 -0.5 0.7 1.2 -0.3 -1.3 -0.0
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 1.5 0.5 0.8 0.1 -0.5 1.2 -0.8 0.4 0.5 -0.1 -0.4 -0.1
Mouth/teeth dental problems: Bleeding gums 2.4 3.1 7.9 0.7 -1.2 -2.8 -2.2 -1.2 -1.8 2.3 -1.4 -1.5 -1.6 -1.6
Blood clot in the leg (DVT) 0.7 0.9 5.5 -1.0 0.7 -0.9 -2.3 -0.6 -0.0 0.4 -0.5 -0.7 -0.3 -0.7
Medication: Paracetamol 0.3 0.4 3.6 0.1 -0.3 -0.0 -0.2 0.2 -0.2 -1.9 -0.5 -0.5 0.2 -0.5
Headache pain in last month 0.2 0.4 2.2 -0.3 0.4 0.2 0.9 0.2 -0.1 -1.5 -0.8 -0.7 0.2 0.4
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.9 0.3 -1.4 0.0 -0.1 -0.1 0.8 0.5 -0.6 0.6 -0.0 -0.5
Glaucoma (self-reported) 2.8 3.3 9.0 1.7 0.6 -1.9 -2.0 -0.5 -1.2 3.0 -1.4 -1.8 -1.8 -2.5
Gout (self-reported) 1.4 2.0 5.3 -1.8 0.0 1.4 0.1 0.1 1.7 -1.4 1.4 1.8 1.1 2.3
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 2.4 -0.0 -1.0 0.3 -0.5 -1.6 0.0 -0.9 -0.3 1.1 0.7 0.3
Medication: Amlodipine 0.7 1.0 5.2 -2.3 0.4 0.1 0.8 -1.4 -0.2 -0.1 -1.4 -0.3 0.9 0.3
Medication: Ventolin 100micrograms inhaler 1.1 1.4 4.2 0.0 -0.4 -0.8 -1.0 -2.1 -1.6 1.1 -2.0 -0.9 -0.1 -1.1
Birth weight 1.4 3.0 6.6 0.9 -0.4 -2.4 -0.3 0.1 -2.1 2.3 -0.8 -1.6 -2.6 -2.5
Chronic bronchitis/emphysema (mother) 0.6 0.7 2.4 0.7 -0.2 0.2 -1.4 -1.6 0.7 1.2 -0.4 0.1 0.3 0.5
High blood pressure (siblings) 1.2 1.8 7.8 -0.8 -0.1 1.8 2.8 0.5 0.9 -1.4 0.5 1.2 0.9 1.4
Forced vital capacity (FVC), Best measure 0.1 0.5 1.5 -0.9 0.6 0.2 -1.1 -0.2 -1.2 0.9 -0.7 -0.7 -0.5 -0.4
Body fat percentage 0.7 2.9 7.3 -2.7 -1.5 2.1 1.4 -0.5 2.2 -1.5 1.3 1.7 0.8 1.8
Leg fat percentage (right) 1.1 3.9 7.3 -2.7 -1.3 2.6 1.5 -1.2 2.5 -1.7 1.4 2.5 1.0 2.2
Arm fat-free mass (right) 0.2 1.3 5.1 -2.2 2.3 1.2 0.2 0.5 -0.5 -0.5 0.0 0.9 0.9 0.6
Exposure to tobacco smoke outside home 0.8 1.0 5.2 -0.9 2.3 0.3 0.5 1.4 1.0 -0.6 1.1 0.4 0.2 0.6
Comparative body size at age 10 0.7 1.9 6.1 1.0 1.1 -1.1 -0.6 -1.2 -1.9 1.4 -2.5 -0.9 -0.2 -1.7
Number of full brothers 1.1 1.4 5.4 1.0 -2.3 -0.6 -0.9 -2.0 0.8 0.7 0.5 0.9 -1.0 0.7
Worry too long after embarrassment 2.0 3.3 6.7 2.1 -0.1 -1.6 -1.7 -1.8 -1.8 1.1 -2.6 -1.8 -1.5 -2.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.4 -0.1 -0.1 -0.6 -0.9 -1.0 0.4 1.2 0.1 -0.3 -1.2 -0.6
Wheeze or whistling in the chest in last year 0.6 1.1 8.3 -0.5 -0.9 0.1 0.7 -2.9 0.2 -0.3 -1.1 -0.0 0.8 0.0
Number of children fathered 0.1 0.1 0.3 -0.6 0.4 -0.3 0.0 -0.1 -0.6 0.5 -0.3 -0.4 0.1 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 2.4 1.0 -0.8 -0.7 -1.5 -1.1 0.3 1.1 -0.4 -0.4 -0.8 -0.4
Age at first live birth 0.4 0.7 4.8 0.7 1.3 -0.3 0.3 2.2 0.3 -0.2 0.7 -0.2 -0.6 -0.1
Pulse wave peak to peak time 0.5 0.6 1.6 0.2 -0.0 1.2 1.1 1.2 1.2 -0.2 0.7 0.5 -0.1 0.5
Health satisfaction 0.4 0.5 1.7 0.2 -0.0 0.0 -1.3 -0.8 1.3 0.0 0.5 0.2 0.5 0.9
Shortness of breath walking on level ground 0.5 0.5 2.5 -0.5 1.6 0.2 -0.8 0.0 0.1 0.3 0.0 0.3 1.2 1.0
Qualifications: College or University degree 1.2 3.7 12.7 1.8 -1.1 -2.1 -1.4 1.4 -1.3 2.6 -0.2 -2.3 -3.6 -1.6
Eye problems/disorders: None of the above 1.7 2.0 5.1 -1.5 0.5 2.2 0.4 0.6 0.6 -2.0 1.5 1.7 1.0 1.7
Mouth/teeth dental problems: Loose teeth 0.5 0.5 2.3 0.9 0.0 -0.7 1.5 0.4 -1.1 0.5 -0.5 -0.5 0.1 -0.6
Emphysema/chronic bronchitis 1.3 1.4 3.7 -0.9 1.1 1.9 1.1 1.9 0.9 -1.1 1.2 1.0 0.5 0.0
Medication for pain relief, constipation, heartburn 0.2 0.3 1.0 0.6 0.2 0.0 -0.4 -0.6 0.7 1.0 -0.3 0.6 0.8 -0.0
Neck or shoulder pain in last month 1.4 2.0 7.3 -1.0 -1.5 0.2 0.6 -2.7 1.8 -0.5 -0.2 1.2 1.5 1.9
Medication: Blood pressure 0.3 0.6 2.7 0.3 1.6 -0.6 0.0 0.1 -1.2 0.3 -0.1 -1.2 -0.7 -0.2
Angina (self-reported) 0.7 1.0 3.2 -0.8 0.9 1.2 1.8 1.1 0.5 -0.4 1.2 0.4 0.5 1.0
Migraine (self-reported) 0.6 0.7 1.7 1.0 -0.3 0.4 -0.9 1.3 0.8 -0.9 1.1 0.2 0.5 1.1
Medication: Ibuprofen 0.3 0.3 0.7 -0.3 -0.3 0.4 0.3 -0.9 -0.6 -0.6 -0.6 0.0 0.6 0.8
Medication: Allopurinol 0.9 1.2 3.0 -1.5 -0.4 1.3 0.5 -0.1 1.1 -1.3 1.1 1.2 0.2 1.7
Medication: Omeprazole 0.8 0.9 2.7 0.1 -1.6 -1.5 -1.5 -0.1 -0.2 0.6 -0.5 -1.0 -1.0 -0.2
Medication: Seretide 50 evohaler 0.6 0.6 1.8 0.0 -0.2 1.2 -1.3 0.3 0.2 -1.2 0.5 1.4 0.1 0.6
Mean time to correctly identify matches 0.6 1.1 4.7 -2.2 -0.7 -1.1 -0.0 -1.1 -0.2 -0.5 -0.9 -1.3 -0.9 -0.8
Heart disease (mother) 0.3 0.4 2.2 0.1 -0.1 0.3 1.5 -1.0 -0.4 -0.2 0.5 0.7 -0.5 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.8 -0.9 0.9 1.0 1.1 0.4 0.0 -1.4 0.6 0.6 0.9 0.7
Whole body fat mass 0.6 2.6 8.9 -3.0 -0.5 2.3 1.1 -0.1 1.7 -1.4 1.0 1.7 1.0 1.7
Leg fat mass (right) 0.8 3.0 7.1 -2.6 0.0 2.7 1.3 -0.4 1.9 -1.4 1.2 2.2 1.2 2.0
Arm predicted mass (right) 0.3 1.4 5.7 -2.4 2.1 1.3 0.5 0.7 -0.2 -0.5 0.1 1.0 0.9 0.8
Pulse rate, automated reading 0.3 0.8 4.0 0.7 0.9 0.2 0.3 -0.9 0.8 -0.8 -2.0 -0.5 1.1 0.1
Alcohol intake frequency. 1.8 4.2 12.1 -2.3 -0.2 2.0 2.7 0.5 1.4 -3.5 1.4 1.5 2.1 2.5
Comparative height size at age 10 0.2 1.3 4.2 -0.7 -0.7 1.0 -0.3 2.1 1.1 0.0 2.0 0.9 0.1 1.5
Number of full sisters 0.5 0.6 1.8 0.3 0.0 0.9 1.1 -0.7 0.7 -0.4 -0.2 0.8 1.3 0.7
Suffer from ‘nerves’ 0.6 1.0 2.1 -1.3 -0.0 1.4 1.5 0.2 1.2 -0.9 0.9 1.0 0.5 0.7
Overall health rating 0.5 1.1 6.8 0.7 -1.3 -1.0 -0.4 -2.6 0.3 -0.0 -0.9 -0.0 -0.5 -0.5
Chest pain or discomfort 0.5 0.7 2.5 -0.6 1.0 0.6 0.7 0.4 0.5 -0.4 0.5 1.1 1.6 1.0
Had major operations 0.9 1.1 3.0 0.1 0.7 1.4 -0.7 0.6 1.1 -0.8 1.0 1.7 1.1 1.2
Age at last live birth 0.3 0.4 1.2 0.8 0.7 -0.0 -0.5 0.8 1.1 -0.1 0.7 0.6 0.3 0.8
Family relationship satisfaction 3.1 3.8 5.4 2.2 -0.9 -2.3 -1.6 -1.6 -1.9 2.2 -1.9 -1.9 -2.3 -2.1
Leg pain on walking 1.4 1.8 6.0 0.6 -2.5 -2.0 -0.9 -1.3 -0.3 1.3 -1.3 -1.3 -0.8 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.3 0.4 -0.4 -0.2 1.1 0.2 -0.5 0.8 -0.6 -0.5 -0.6 -0.4
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.7 1.1 -0.2 0.6 -0.9 1.2 0.1 -0.4 1.1 1.3 0.0 0.4
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 2.2 -1.5 1.3 1.3 0.1 1.5 0.1 -0.6 1.4 0.7 1.0 1.3
Medication: Aspirin 0.1 0.2 0.5 -0.3 0.2 0.3 0.5 -0.1 -0.3 0.3 0.7 0.1 -0.4 0.6
Supplements: Vitamin C 1.1 1.3 2.9 -0.8 1.3 1.4 1.1 1.0 0.7 -1.7 1.2 1.1 0.9 1.0
Knee pain experienced in last month 1.2 1.8 7.2 0.8 -2.7 -1.1 -1.5 -1.2 0.6 2.2 -0.7 -0.3 -0.9 -0.9
Hypertension (Self-reported) 0.4 1.0 6.6 -1.0 -0.8 -0.4 -1.2 -2.6 -0.2 0.1 -1.0 0.0 0.2 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.6 -0.6 -0.9 -1.3 -0.1 -0.3 -0.2 -0.5 -0.7 -0.7 0.0 -0.4
Illnesses of father: Heart disease 1.5 2.0 5.1 0.1 -0.1 2.1 0.3 1.4 1.6 -1.9 1.7 2.2 0.4 1.5
Illnesses of siblings: Diabetes 0.6 0.7 3.8 -0.1 1.0 0.8 -2.0 -0.8 0.1 -0.1 0.4 0.8 1.0 0.6
Smoking status: Previous 0.5 0.7 1.8 -1.1 -1.4 -0.2 1.2 -1.4 0.9 -0.6 -0.5 0.3 0.5 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 3.8 -0.1 -1.9 -0.3 -2.0 -0.8 -0.1 -0.0 -0.4 -0.3 -1.0 -0.1
Whole body fat-free mass 0.2 0.9 3.8 -1.8 1.9 1.0 -0.3 0.7 -0.7 0.4 -0.1 0.6 0.6 0.3
Leg fat-free mass (right) 0.1 0.6 1.8 -1.2 1.3 0.5 -0.7 0.3 -0.9 0.8 -0.8 -0.0 0.3 -0.1
Arm fat percentage (left) 0.6 2.2 5.3 -2.3 -1.0 2.1 0.9 -0.8 1.9 -1.3 0.8 1.5 1.2 1.7
Average weekly red wine intake 0.2 0.3 1.5 0.5 -0.1 -0.4 0.3 0.0 -1.2 0.1 -0.5 -0.6 -0.8 -0.7
Handedness (chirality/laterality): Left-handed 1.0 1.1 2.7 -1.6 0.1 0.7 0.1 1.2 1.1 -0.5 1.5 1.6 0.1 1.2
Mood swings 0.1 0.2 1.2 0.1 1.1 -0.0 -0.6 -0.0 -0.1 -0.1 0.6 0.4 0.0 -0.0
Loneliness, isolation 0.8 1.1 4.7 1.6 -1.0 -0.8 2.2 -1.1 0.4 -0.7 0.5 0.6 0.1 0.9
Long-standing illness, disability or infirmity 0.8 1.2 3.5 0.4 -1.9 -0.6 1.8 -1.9 -0.1 0.9 -1.2 0.1 0.0 0.3
Ever had bowel cancer screening 0.6 0.7 3.2 -0.2 0.5 0.8 -0.9 -0.5 -0.4 -1.8 -0.2 0.1 1.6 0.4
Diabetes diagnosed by doctor 0.4 0.7 2.5 0.3 1.6 -1.0 -0.8 0.0 -0.4 0.6 -1.1 -0.9 -0.2 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 2.0 0.5 0.7 0.1 1.0 1.1 0.3 -0.7 0.3 -0.1 1.4 1.3
Friendships satisfaction 1.1 1.3 3.2 0.8 -0.7 -1.8 -1.5 -0.6 -0.9 0.8 -0.7 -1.6 -1.4 -1.1
Qualifications: nursing, teaching 0.8 1.3 3.2 -0.6 1.5 0.6 0.8 1.6 0.6 -1.2 1.8 1.1 0.3 1.4
Commuting to job workplace: Walk 1.1 1.2 3.2 0.3 0.8 -0.7 -1.3 0.1 -1.2 1.0 -1.0 -1.8 -1.2 -1.3
Eye problems/disorders: Cataract 0.3 0.3 1.7 -0.1 -1.3 -0.9 -0.7 0.2 0.4 0.0 0.1 -0.4 -0.1 0.2
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.8 0.5 -0.5 -1.4 -0.3 -0.7 -0.2 0.9 -1.1 -0.9 -0.4 -0.8
Medication for cholesterol 0.9 1.4 4.9 2.2 1.5 -0.3 0.9 1.2 -1.1 0.5 0.1 -0.9 -1.1 -1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.5 2.9 5.3 1.1 1.8 -0.9 0.1 2.3 -2.2 2.1 0.7 -1.5 -2.3 -2.0
Back pain experienced in last month 1.0 1.4 7.7 -0.7 -2.8 -0.5 0.6 -1.8 1.7 -0.4 -0.0 0.1 0.0 0.7
Mineral and other dietary supplements 1.5 2.1 3.9 -1.7 1.6 1.6 1.0 0.7 1.2 -2.0 0.6 0.9 1.9 1.6
Breast cancer (self-reported) 0.5 0.6 3.3 -0.3 -1.8 0.0 0.9 -0.9 0.3 -0.1 0.1 0.3 0.1 1.2
Asthma (self-reported) 0.2 0.5 2.0 0.6 -1.4 0.3 0.7 -1.1 -0.2 -0.1 -0.9 0.4 -0.3 -0.0
Osteoporosis (self-reported) 0.5 0.6 2.3 0.2 -0.1 -0.9 -0.2 -0.7 -1.0 1.5 -0.3 -1.0 -0.8 -0.4
Osteoarthritis (self-reported) 0.7 0.9 4.7 -1.4 -2.2 -0.3 0.8 -1.3 0.2 -0.2 -0.4 0.3 -0.2 -0.2
Medication: Aspirin 0.2 0.2 0.8 -0.2 0.2 0.5 0.3 -0.1 -0.2 0.6 0.9 0.3 -0.4 0.8
Medication: Gliclazide 0.8 0.9 4.0 1.0 1.2 -0.6 1.3 2.0 -0.1 -0.4 0.8 -0.3 -0.0 0.3
Illnesses of father: None of the above (group 1) 0.7 0.8 3.3 -0.6 -0.6 -1.2 1.0 0.3 -1.2 0.2 -0.6 -1.8 -0.6 -0.5
Smoking status: Current 0.5 0.8 3.1 0.7 1.8 -0.3 0.9 1.0 -0.8 0.3 -0.9 -0.9 0.4 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 2.3 -0.8 -0.0 -0.2 -0.9 -1.3 -0.1 -0.3 -1.5 -0.8 0.2 -0.4
Whole body water mass 0.2 0.9 3.5 -1.7 1.9 1.0 -0.3 0.7 -0.7 0.4 -0.2 0.6 0.6 0.3
Leg predicted mass (right) 0.1 0.5 1.9 -1.2 1.4 0.5 -0.7 0.3 -0.8 0.8 -0.7 -0.0 0.3 -0.0
Arm fat mass (left) 0.6 2.4 8.5 -2.9 -0.1 2.2 0.9 -0.5 1.5 -1.4 0.5 1.5 1.5 1.8
Number of self-reported non-cancer illnesses 0.7 1.2 5.3 -0.3 -1.4 -1.0 -0.4 -2.3 0.1 0.5 -1.9 -0.6 0.5 -0.1
Average weekly champagne plus white wine intake 0.4 0.6 2.4 -0.7 -0.6 -0.9 0.4 -0.7 0.3 1.5 -0.2 -0.9 -1.0 -0.2
Miserableness 0.5 0.8 1.9 -1.0 1.4 1.2 -0.6 0.5 0.4 -1.3 0.8 0.9 0.6 0.4
Guilty feelings 0.8 1.2 3.2 1.4 1.1 -1.0 -1.1 -0.4 -0.7 0.7 -1.8 -1.2 -0.3 -1.5
Wears glasses or contact lenses 0.2 0.2 0.5 -0.2 -0.7 -0.1 -0.6 0.2 -0.1 -0.0 -0.7 -0.4 -0.5 -0.5
Ever taken oral contraceptive pill 0.9 1.0 3.0 0.9 -0.8 0.6 0.6 0.1 1.2 -0.7 1.7 1.3 -0.4 1.1
Hearing aid user 0.3 0.3 1.1 -0.6 0.1 -0.3 -0.5 -0.7 -1.0 -0.4 -0.7 -0.6 -0.3 -0.6
Mother’s age at death 1.9 2.4 5.9 1.4 0.2 -2.2 0.1 0.4 -1.7 1.5 -1.6 -2.4 -1.3 -1.9
Financial situation satisfaction 1.5 1.8 4.7 2.2 0.1 -1.2 -1.4 -0.3 -1.9 1.2 -0.7 -1.2 -1.6 -1.6
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.5 -1.1 -0.8 0.7 1.0 -0.9 1.2 -1.6 0.4 0.7 0.7 0.9
Commuting to job workplace: Public transport 0.3 0.3 0.7 0.4 0.8 -0.4 0.1 0.1 0.2 0.7 -0.8 -0.8 0.4 -0.6
Eye problems/disorders: Glaucoma 3.4 4.0 7.8 1.2 -0.7 -2.4 -2.6 -1.2 -1.1 2.6 -1.9 -2.4 -1.9 -2.8
Medication: Blood pressure 1.3 2.5 7.0 -2.4 -2.6 0.7 -0.6 -2.3 1.7 -0.7 -0.5 1.2 1.2 1.6
Pain type(s) experienced in last month: Hip pain 2.1 2.6 5.5 -1.7 -0.9 1.8 2.0 -0.2 2.3 -2.3 0.9 1.3 1.0 1.9
Supplements: Fish oil (including cod liver oil) 1.4 1.8 7.1 0.6 -2.7 -1.6 -0.1 -1.8 -0.7 1.2 -0.8 -0.7 -1.5 -1.0
High cholesterol (Self-reported) 0.9 1.7 9.4 -0.9 -2.1 -0.7 -1.4 -3.1 0.1 -0.5 -0.8 -0.0 0.3 0.6
Medication: Bendroflumethiazide 0.7 1.1 3.4 -1.9 -1.8 0.3 -0.9 -1.8 0.3 -0.5 -0.5 0.5 0.2 0.8
Medication: Paracetamol 0.2 0.3 1.6 -0.4 -1.0 -0.1 -0.6 -0.2 -0.1 -1.3 -0.6 -0.3 -0.0 -0.4
Medication: Lisinopril 0.2 0.3 0.6 -0.2 0.5 -0.1 -0.7 -0.3 -0.6 0.8 -0.6 -0.8 0.1 -0.3
Medication: Atorvastatin 0.5 0.7 2.8 -0.6 -1.0 -0.5 -1.4 -1.7 -0.1 0.9 -0.1 -0.2 0.2 0.3
Illnesses of father: High blood pressure 2.1 2.6 8.2 1.2 -2.9 -1.1 -2.2 -2.4 -1.1 1.5 -1.6 -0.1 -0.5 -0.9
Alcohol drinker status: Never 0.7 0.9 3.5 -0.0 0.7 1.3 1.9 0.8 0.5 -0.5 0.6 0.7 1.2 0.7
Ever smoked 0.3 0.4 2.5 -0.1 1.1 -0.1 1.6 0.5 0.3 -0.3 -0.3 -0.4 0.1 -0.6
Basal metabolic rate 0.2 1.0 4.5 -2.1 1.5 1.4 0.0 0.7 -0.2 -0.0 0.2 0.9 0.7 0.7
Leg fat percentage (left) 0.9 3.2 7.7 -2.8 -1.3 2.4 1.3 -1.4 2.2 -1.7 0.8 2.2 1.0 1.7
Arm fat-free mass (left) 0.3 1.3 5.0 -2.2 2.2 1.2 0.4 0.9 -0.7 -0.2 -0.1 0.7 0.8 0.4
Number of operations (self-reported) 0.2 0.3 1.8 1.3 0.4 -0.4 0.0 0.2 -0.7 0.9 0.1 0.2 -0.1 -0.1
Average weekly beer plus cider intake 0.9 1.3 4.2 0.0 -1.3 1.3 1.6 0.2 1.0 -2.0 1.2 1.2 -0.8 0.4
Irritability 0.4 0.6 2.7 -0.5 -0.4 0.3 0.2 -0.6 0.8 -0.1 0.3 1.6 1.4 0.9
Risk taking 0.4 0.6 2.0 -0.8 -0.6 0.5 -0.3 -1.4 0.7 0.5 -0.5 0.3 1.3 0.9
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.6 0.6 1.3 -0.4 0.0 0.2 -0.9 0.6 -0.2 -0.5 0.1 -0.4
Fractured/broken bones in last 5 years 0.6 0.8 3.1 -0.4 1.8 0.6 1.6 1.3 0.5 0.1 -0.1 -0.4 0.2 0.1
Age started oral contraceptive pill 0.5 0.6 2.5 -1.6 0.8 0.5 -0.5 0.2 1.2 -0.6 0.5 -0.0 0.7 0.4
Diastolic blood pressure, automated reading 1.7 5.4 17.1 1.3 -2.0 -1.8 -2.6 -4.1 -2.4 2.4 -3.0 -1.3 -1.1 -1.7
Ever depressed for a whole week 0.3 0.4 1.8 0.4 0.0 0.7 0.4 -0.4 0.4 0.1 -0.0 0.7 1.0 1.3
Unable to work because of sickness or disability 1.1 1.4 3.7 -0.2 -0.1 0.7 1.1 -1.9 1.6 -1.0 0.1 1.5 1.3 1.5
Commuting to job workplace: Cycle 0.4 0.5 2.3 0.4 0.7 0.1 1.4 1.5 -0.3 0.5 0.1 -0.5 -0.3 -0.1
Myopia 1.5 2.2 5.4 1.1 -0.5 -1.3 -1.3 0.9 -1.4 2.2 -0.1 -1.5 -2.3 -1.8
Vascular/heart problems diagnosed by doctor 0.4 1.0 6.4 1.1 1.2 -0.1 0.7 2.5 -0.2 -0.1 0.5 -0.4 -0.3 -0.9
Cholesterol lowering medication 0.7 1.1 6.8 -0.3 -2.6 -0.4 -1.3 -1.6 0.4 -0.1 -0.6 0.2 0.0 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 2.0 -0.4 -1.0 -1.0 -1.1 1.0 -0.1 0.6 0.2 -0.8 -1.4 -0.1
Pain experienced in last month 1.1 1.9 10.2 0.6 3.2 1.0 -0.7 2.0 -0.8 0.7 1.6 0.5 0.3 0.4
Supplements: Calcium 0.2 0.2 0.7 0.8 0.7 -0.5 0.5 0.5 -0.5 0.7 -0.1 -0.3 -0.0 0.1
Basal cell carcinoma (self-reported) 2.7 3.2 6.9 2.6 -0.2 -2.6 -0.2 0.6 -2.2 1.5 -1.0 -2.2 -2.4 -1.8
Heart attack/myocardial infarction (self-reported) 1.7 2.2 8.1 0.3 -1.9 -1.5 0.1 -0.6 -1.4 1.8 -0.2 -1.6 -2.9 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 4.0 -1.1 0.8 -0.6 -2.0 -0.5 0.2 0.3 -0.3 -0.5 0.1 -0.3
Heart disease (siblings) 2.0 2.4 4.9 -1.6 -1.0 1.1 1.6 -2.0 2.2 -1.6 1.0 1.7 0.7 1.9
Alcohol drinker status: Previous 0.5 0.5 3.6 0.3 0.5 -0.5 1.9 -0.2 -0.1 -0.8 -0.6 -0.3 0.5 0.4
Pack years of smoking 1.0 1.5 2.8 -1.5 1.7 1.4 0.7 0.8 1.7 -1.2 0.6 1.3 1.2 0.7
Impedance of whole body 0.5 2.7 9.8 1.1 -3.1 -1.0 1.4 1.7 0.8 0.6 2.4 -0.4 -2.5 0.2
Leg fat mass (left) 0.7 2.6 6.9 -2.6 -0.0 2.5 1.2 -0.5 1.8 -1.4 0.8 2.0 1.3 1.8
Arm predicted mass (left) 0.2 1.2 4.7 -2.2 1.9 1.3 0.5 0.8 -0.3 -0.5 0.1 0.9 0.8 0.6