[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr5:71,557,313-73,125,146

Best TWAS P=1.53e-08 · Best GWAS P=1.17e-08 conditioned to 3.4e-06

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	YFS	Blood	FCHO2	0.23	0.24	lasso	6	0.29	2.8e-97	5.4	5.7	1.5e-08	-0.20	0.01	0.99	TRUE
7	GTEx	Pancreas	FCHO2	0.11	0.04	enet	7	0.03	1.8e-02	4.8	5.6	1.9e-08	-0.26	0.05	0.80	FALSE
8	METSIM	Adipose	FCHO2	0.06	0.08	lasso	5	0.08	1.9e-11	5.1	5.6	2.6e-08	-0.23	0.02	0.98	FALSE
1	GTEx	Adipose Visceral Omentum	FCHO2	0.27	0.10	lasso	5	0.06	6.2e-04	5.0	5.5	4.6e-08	-0.23	0.02	0.96	FALSE
9	NTR	Blood	FCHO2	0.04	0.03	lasso	4	0.03	2.4e-11	5.1	5.3	9.7e-08	-0.19	0.03	0.97	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	TMEM171	0.38	0.29	bslmm	389	0.28	2.0e-36	-5.1	-5.2	1.7e-07	0.33	0.03	0.97	FALSE
3	GTEx	Artery Aorta	FCHO2	0.07	0.04	lasso	2	0.03	5.2e-03	5.1	5.2	1.8e-07	-0.20	0.02	0.90	FALSE
2	GTEx	Adrenal Gland	FCHO2	0.11	0.03	lasso	3	0.01	1.2e-01	5.0	5.2	2.1e-07	-0.21	0.05	0.72	FALSE
4	GTEx	Cells Transformed fibroblasts	FCHO2	0.10	0.04	lasso	10	0.05	6.0e-05	5.1	5.2	2.4e-07	-0.14	0.02	0.98	FALSE
5	GTEx	Esophagus Mucosa	FCHO2	0.15	0.07	lasso	2	0.09	1.1e-06	5.1	-5.1	3.0e-07	0.20	0.03	0.97	FALSE
6	GTEx	Nerve Tibial	FCHO2	0.10	0.08	enet	17	0.05	3.4e-04	5.0	5.1	3.1e-07	-0.26	0.02	0.98	FALSE