Best TWAS P=1.53e-08 · Best GWAS P=1.17e-08 conditioned to 3.4e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | FCHO2 | 0.27 | 0.10 | lasso | 5 | 0.06 | 6.2e-04 | 5.0 | 5.5 | 4.6e-08 | -0.23 | 0.02 | 0.96 | FALSE |
| 2 | GTEx | Adrenal Gland | FCHO2 | 0.11 | 0.03 | lasso | 3 | 0.01 | 1.2e-01 | 5.0 | 5.2 | 2.1e-07 | -0.21 | 0.05 | 0.72 | FALSE |
| 3 | GTEx | Artery Aorta | FCHO2 | 0.07 | 0.04 | lasso | 2 | 0.03 | 5.2e-03 | 5.1 | 5.2 | 1.8e-07 | -0.20 | 0.02 | 0.90 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | FCHO2 | 0.10 | 0.04 | lasso | 10 | 0.05 | 6.0e-05 | 5.1 | 5.2 | 2.4e-07 | -0.14 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Esophagus Mucosa | FCHO2 | 0.15 | 0.07 | lasso | 2 | 0.09 | 1.1e-06 | 5.1 | -5.1 | 3.0e-07 | 0.20 | 0.03 | 0.97 | FALSE |
| 6 | GTEx | Nerve Tibial | FCHO2 | 0.10 | 0.08 | enet | 17 | 0.05 | 3.4e-04 | 5.0 | 5.1 | 3.1e-07 | -0.26 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Pancreas | FCHO2 | 0.11 | 0.04 | enet | 7 | 0.03 | 1.8e-02 | 4.8 | 5.6 | 1.9e-08 | -0.26 | 0.05 | 0.80 | FALSE |
| 8 | METSIM | Adipose | FCHO2 | 0.06 | 0.08 | lasso | 5 | 0.08 | 1.9e-11 | 5.1 | 5.6 | 2.6e-08 | -0.23 | 0.02 | 0.98 | FALSE |
| 9 | NTR | Blood | FCHO2 | 0.04 | 0.03 | lasso | 4 | 0.03 | 2.4e-11 | 5.1 | 5.3 | 9.7e-08 | -0.19 | 0.03 | 0.97 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | TMEM171 | 0.38 | 0.29 | bslmm | 389 | 0.28 | 2.0e-36 | -5.1 | -5.2 | 1.7e-07 | 0.33 | 0.03 | 0.97 | FALSE |
| 11 | YFS | Blood | FCHO2 | 0.23 | 0.24 | lasso | 6 | 0.29 | 2.8e-97 | 5.4 | 5.7 | 1.5e-08 | -0.20 | 0.01 | 0.99 | TRUE |