Hub : Genes

TMEM171

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.383	0.0532	0.00000	0.287	0.198	0.272	0.282	0.281	4.4e-37	7.6e-25	6.3e-35	2e-36	2.9e-36
2	TCGA	Colon Adenocarcinoma	0.161	0.0620	0.00037	0.054	0.055	0.053	NA	0.069	4.6e-04	4.1e-04	5.0e-04	NA	8.0e-05
3	TCGA	Thyroid Carcinoma	0.086	0.0390	0.00190	0.049	0.016	0.025	NA	0.041	1.4e-05	8.9e-03	1.7e-03	NA	7.3e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	1.0	2.0	1.4	0.9	-0.5
Bipolar Disorder or Schizophrenia	2.1	5.2	6.7	2.6	2.4	-1.9
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	-0.1	0.3	0.1
Depression (Nagel 2018)	0.2	0.3	0.6	0.8	0.5	-0.3
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	0.5	0.7	-0.1
Neuroticism (Nagel 2018)	0.4	1.0	1.7	1.1	1.3	0.4
Schizophrenia (2018)	2.3	4.7	5.4	2.2	2.3	-2.0
Schizophrenia vs Biploar Disorder	1.2	1.6	3.5	-0.1	1.1	-1.9
Worry (Nagel 2018)	0.4	0.8	1.3	1.2	0.9	0.5
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.3	-0.5	0.1
Alzheimer’s Disease (in father)	4.0	4.4	5.4	2.3	2.2	-1.7
Alzheimer’s Disease (including proxy)	1.4	2.1	3.6	1.9	1.2	-1.1
Crohns Disease (2017)	0.8	1.7	2.3	1.5	0.8	-1.5
Irritable Bowel Disease (IBD)	2.3	5.4	8.9	3.0	2.5	-1.1
Ulcerative Colitis (UC)	2.7	5.1	7.7	2.8	2.8	-0.1
Major Depression (MDD)	0.2	0.2	0.4	0.6	0.2	-0.6
Reaction Time	0.2	0.5	1.1	1.0	0.4	-0.4
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.1	0.0	0.3	-0.1
Breast Cancer	2.0	4.8	6.5	-2.5	-2.5	1.2
Ovarian Cancer	0.5	0.6	1.1	0.6	0.7	-1.1
Prostate Cancer	0.0	0.0	0.0	0.1	0.0	-0.2
Age at First Birth	0.1	0.2	0.4	0.4	0.6	-0.3
Bipolar Disorder (2011)	0.6	0.6	1.4	1.2	0.0	0.5
Body Mass Index (BMI) (2010)	0.6	0.8	2.2	-0.4	0.2	1.5
Coronary Artery Disease (CAD)	0.0	0.1	0.1	0.3	0.3	-0.1
Crohns Disease (2012)	2.7	4.4	6.2	2.5	1.8	-1.9
Mean Putamen Volume	2.1	2.4	3.4	1.8	1.8	0.8
Fasting Glucose	0.4	0.5	0.9	-0.3	-0.7	0.9
HbA1C	2.8	3.1	4.5	-1.6	-1.5	2.1
HDL Cholesterol	2.2	3.7	10.8	-0.4	-0.3	-3.3
LDL Cholesterol	2.0	3.1	4.4	2.1	2.1	0.8
Lupus	0.2	0.3	0.5	-0.6	-0.7	0.0
Neuroticism (2016)	0.2	0.3	0.7	-0.8	-0.6	-0.0
Primary Biliary Cirrhosis	1.2	1.7	2.1	-1.4	-1.4	-1.0
Rheumatoid Arthritis	0.9	1.3	1.5	-1.2	-1.2	1.0
Schizophrenia (2014)	2.5	5.5	9.4	1.7	2.1	-3.1
Triglycerides	0.8	1.3	3.3	-0.1	0.8	1.8
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.3	-0.5	-0.2	-1.1
Ulcerative Colitis	1.8	2.7	4.6	2.1	1.8	-0.5
Blood Eosinophil Count	0.2	1.8	4.1	2.0	0.8	0.8
Blood Platelet Count	0.4	4.5	7.8	-2.4	-0.3	-2.8
Blood Red Count	0.4	4.0	7.6	2.1	2.8	-0.3
Blood White Count	0.5	3.9	10.7	1.0	-0.2	-3.3
Heel T-Score	1.7	13.7	17.7	-3.9	-2.9	-4.2
BMI	0.1	0.3	0.8	-0.9	0.0	-0.5
Height	0.5	10.6	24.9	2.0	-1.7	5.0
Waist Hip Ratio (WHR)	0.2	1.0	1.7	1.1	0.2	1.3
Systolic Blood Pressure	0.8	4.1	7.2	-2.7	-2.1	0.8
Smoking Status	0.4	1.0	1.6	1.3	0.9	-0.8
Allergy or Eczema	1.0	2.7	4.2	-2.0	-1.9	0.5
Cardiovascular Disease	0.3	1.1	1.6	1.3	1.1	0.7
Hypothyroidism (self reported)	7.8	17.9	27.4	-5.2	-5.1	0.8
Respiratory disease	0.8	1.7	3.6	-1.2	-1.9	0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	-0.4	0.6	0.1
Lung FEV1/FVC ratio	1.3	6.6	11.1	2.7	3.3	-1.1
Lung FVC	0.4	2.1	2.9	-1.6	-0.8	1.7
Neuroticism	0.2	0.6	1.6	-0.2	-0.0	1.3
Chronotype (morning person)	0.2	0.5	1.2	1.1	0.5	0.3
Hair Pigment	0.1	1.6	3.1	1.8	0.4	1.3
Tanning	0.1	1.5	3.5	-0.8	-1.9	0.6
Hand grip strength (left)	0.1	0.3	0.9	-0.9	0.1	0.0
Number of treatments/medications taken	0.8	1.4	2.6	-1.0	-1.6	0.8
Average weekly spirits intake	0.8	1.0	1.8	1.2	1.3	0.1
Sensitivity / hurt feelings	0.1	0.2	0.4	0.0	0.7	0.5
Frequency of depressed mood in last 2 weeks	1.2	1.6	2.7	1.4	1.7	0.5
Hearing difficulty/problems: Yes	0.6	0.9	2.0	0.2	0.8	-1.4
Relative age of first facial hair	0.8	1.6	2.3	1.3	1.5	0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	0.9	-0.9	-0.9	-0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	-0.5	-0.4	0.2
Ever had hysterectomy (womb removed)	0.7	0.8	1.4	-1.0	-1.2	0.1
Systolic blood pressure, automated reading	1.5	4.3	7.8	-2.8	-2.2	0.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.2	-0.8	-0.3	1.1
Angina	0.2	0.3	0.9	0.9	0.1	-0.1
Medication for hormone replacement therapy	0.4	0.4	1.3	-0.0	-0.2	-1.1
Vitamin and mineral supplements	0.5	0.7	0.9	-1.0	-1.0	0.5
Supplements: Zinc	1.0	1.1	1.7	1.2	1.3	-0.0
Medication: Co-codamol	0.1	0.1	0.3	-0.0	-0.2	0.5
Medication: Metformin	0.5	0.6	1.3	0.7	1.2	0.2
Diabetes (father)	0.4	0.4	0.9	-1.0	-0.4	-0.5
Diabetes (mother)	0.5	0.6	1.4	0.6	-0.1	-1.2
Severe depression (siblings)	0.3	0.4	0.7	-0.5	-0.5	-0.8
Pack years adult smoking proportion	0.1	0.2	0.2	-0.4	-0.5	-0.4
Impedance of leg (right)	3.8	18.2	29.4	5.4	5.0	-0.6
Leg fat-free mass (left)	1.1	5.8	9.2	-2.2	-3.0	1.8
Trunk fat percentage	0.0	0.0	0.0	-0.2	-0.2	0.1
Hand grip strength (right)	0.0	0.1	0.2	-0.1	0.5	-0.1
Townsend deprivation index at recruitment	1.2	1.7	4.0	1.0	0.1	2.0
Current tobacco smoking	0.9	1.5	2.1	1.4	1.4	-0.6
Average weekly fortified wine intake	1.6	1.9	3.4	-1.8	-1.0	-1.2
Maternal smoking around birth	1.6	2.3	3.2	-1.6	-1.8	1.1
Fed-up feelings	0.6	1.1	1.7	0.8	1.3	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	0.8	0.2	0.4
Relative age voice broke	1.6	2.4	4.3	1.4	2.1	-0.9
Taking other prescription medications	0.5	0.7	1.8	-0.7	-1.3	0.1
Age when periods started (menarche)	0.6	1.5	3.3	0.9	0.7	-1.8
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.2	0.4	0.4	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	1.8	-1.3	-0.6	-1.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.7	-0.8	-0.6	-0.2
Qualifications: CSEs or equivalent	0.2	0.3	0.5	0.7	0.6	0.0
Serious illness, injury or assault to yourself	0.2	0.2	0.3	-0.5	-0.5	-0.3
High blood pressure	0.8	2.2	6.2	0.5	0.5	2.5
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.2	-1.1	-1.1	0.2
Multivitamins +/- minerals	0.6	0.8	1.0	0.9	0.8	-1.0
Stomach or abdominal pain in last month	0.5	0.6	0.8	0.8	0.9	0.7
Supplements: Glucosamine	5.2	6.8	10.2	-3.1	-3.2	1.0
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	1.9	-1.4	-1.4	-0.4
Medication: Atenolol	0.0	0.0	0.1	0.3	0.1	0.0
Medication: Levothyroxine sodium	3.8	6.4	10.3	-3.2	-2.7	1.2
Sitting height	0.6	4.2	10.4	-0.2	-1.5	3.2
Chronic bronchitis/emphysema (father)	0.9	1.1	1.5	-0.8	-1.0	1.2
High blood pressure (mother)	0.4	0.5	1.0	-1.0	-0.5	-0.5
Body mass index (BMI)	0.4	1.7	3.4	-1.8	-1.3	-0.3
Impedance of leg (left)	2.7	13.0	21.3	4.6	4.2	-0.6
Leg predicted mass (left)	1.1	5.8	9.5	-2.2	-3.1	1.7
Trunk fat mass	0.1	0.2	0.3	-0.3	-0.5	0.6
Waist circumference	0.2	0.7	1.2	-0.4	-0.9	1.1
Number of incorrect matches in round	0.4	0.6	1.1	0.8	0.1	1.0
Past tobacco smoking	0.0	0.1	0.1	-0.4	-0.2	-0.1
Alcohol usually taken with meals	0.2	0.3	1.0	0.2	1.0	0.1
Nervous feelings	0.8	1.4	1.8	1.3	1.0	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	-0.0	-0.2	0.1
Hearing difficulty/problems with background noise	1.2	2.0	3.5	1.5	1.9	-0.2
Hair/balding pattern: Pattern 2	1.0	1.3	3.5	-0.4	-0.4	-1.9
Had menopause	0.5	0.6	1.2	-1.1	-0.7	0.3
Had other major operations	0.6	0.7	1.9	-0.1	-0.5	-1.4
Forced vital capacity (FVC)	0.3	1.0	2.9	0.2	0.1	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	2.7	-1.3	-0.9	-1.6
Ever unenthusiastic/disinterested for a whole week	2.0	2.5	3.2	1.8	1.8	-1.1
Qualifications: None of the above	0.9	1.9	3.7	1.0	1.0	1.9
Financial difficulties in last 2 years	0.4	0.6	1.2	0.7	0.2	-1.1
Mouth/teeth dental problems	0.6	0.8	1.8	0.5	0.7	-1.3
Heart attack	0.0	0.0	0.0	-0.1	-0.1	0.0
Allergy	0.6	1.4	1.7	0.8	1.3	-1.3
Pain all over the body in last month	1.3	1.4	2.3	-1.3	-1.5	0.2
Diabetes (self-reported)	0.6	0.9	1.5	-1.2	-1.0	0.5
Hayfever/allergic rhinitis (self-reported)	2.5	3.3	5.5	-2.1	-2.3	0.2
Medication: Ramipril	1.5	1.9	2.7	1.6	1.3	1.1
Medication: Simvastatin	2.1	3.1	3.6	-1.9	-1.9	1.5
Fluid intelligence score	0.5	1.0	1.3	0.9	1.1	-1.0
Illnesses of siblings	1.8	2.5	3.6	-1.4	-1.9	1.4
Neuroticism score	0.4	0.8	0.9	0.8	0.9	0.9
Weight	0.4	1.9	2.6	-0.9	-1.6	1.6
Impedance of arm (right)	0.5	2.5	4.5	2.1	1.6	0.6
Arm fat percentage (right)	0.3	1.2	2.4	-1.5	-1.1	0.0
Trunk fat-free mass	0.7	4.2	6.5	-1.2	-2.2	2.6
Hip circumference	0.3	1.1	2.0	-1.1	-1.4	0.4
Time employed in main current job	0.1	0.2	0.3	-0.5	-0.3	-0.3
Alcohol intake versus 10 years previously	1.3	2.0	3.0	-1.7	-1.5	-0.9
Father’s age at death	0.1	0.2	0.2	-0.5	-0.4	-0.4
Worrier / anxious feelings	0.5	0.9	1.7	0.6	1.3	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.7	0.7	0.5	0.9
Falls in the last year	1.6	2.1	6.0	0.1	-0.6	2.5
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	-0.3	-0.2	0.8
Number of live births	0.1	0.1	0.2	-0.4	-0.4	0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	0.8	0.8	0.9	0.7
Pulse rate	0.9	1.6	2.7	1.4	1.6	0.2
Happiness	0.8	0.9	1.6	0.5	1.0	-1.3
Noisy workplace	0.4	0.5	1.4	-0.0	0.0	1.2
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.1	-0.2	0.1	-0.2
Serious illness, injury or assault of a close relative in last 2 years	3.0	3.4	6.0	-1.8	-1.1	-2.5
Mouth/teeth dental problems: Dentures	0.9	1.5	3.6	-0.6	-0.8	1.9
Asthma	1.9	3.7	6.7	-2.1	-2.6	0.3
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.0	-0.9	-1.7	-0.7
Medication: Cholesterol lowering	0.3	0.4	0.6	0.7	0.7	0.4
Depression (self-reported)	0.5	0.6	1.0	0.8	1.0	0.2
Medication: Lansoprazole	0.2	0.2	0.4	-0.3	-0.7	0.3
Prospective memory result	0.6	0.7	1.1	1.1	1.0	-0.1
Lung cancer (father)	1.1	1.3	1.8	1.3	1.1	0.9
Illnesses of mother	1.2	1.4	4.2	-0.0	0.3	2.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.3	1.0	0.9	1.1
Pulse wave Arterial Stiffness index	0.1	0.2	0.4	-0.4	-0.6	-0.1
Impedance of arm (left)	0.7	3.1	5.5	2.3	1.9	0.4
Arm fat mass (right)	0.4	1.8	2.5	-1.6	-1.5	0.8
Trunk predicted mass	0.7	4.2	6.5	-1.2	-2.2	2.5
Standing height	0.7	6.9	16.7	1.9	-0.6	4.1
Length of working week for main job	4.1	4.6	6.6	-1.9	-2.6	1.9
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.1	-0.3	0.5
Breastfed as a baby	0.3	0.4	0.7	0.7	0.8	0.1
Tense / ‘highly strung’	1.3	2.1	3.1	1.8	1.6	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.5	0.0	0.6
Hair/balding pattern: Pattern 4	1.1	2.7	5.4	1.6	2.3	0.2
Birth weight of first child	4.6	8.3	14.4	-3.8	-3.2	0.7
Peak expiratory flow (PEF)	0.8	1.9	5.2	0.1	0.6	2.3
Pulse wave reflection index	0.5	0.6	1.4	0.6	-0.4	-1.2
Ever highly irritable/argumentative for 2 days	1.4	1.6	1.7	1.3	1.2	-1.3
Loud music exposure frequency	0.0	0.0	0.0	0.1	0.1	0.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	4.0	0.2	0.9	-2.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	0.7	0.8	0.8	-0.7
Blood clot in the leg (DVT)	0.1	0.1	0.4	0.1	-0.2	0.6
Medication: Paracetamol	0.8	1.2	2.9	1.7	0.7	-0.5
Headache pain in last month	0.2	0.4	0.7	-0.4	-0.6	-0.8
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	3.2	0.0	0.2	-1.8
Glaucoma (self-reported)	2.2	2.5	4.6	2.2	1.7	0.5
Gout (self-reported)	7.8	10.7	31.9	-0.2	0.3	-5.6
Hypothyroidism/myxoedema (self-reported)	5.7	11.2	15.5	-3.9	-3.7	2.1
Medication: Amlodipine	0.6	0.9	1.2	-1.1	-0.7	1.0
Medication: Ventolin 100micrograms inhaler	2.1	2.7	3.2	-1.8	-1.8	-1.3
Birth weight	0.3	0.6	1.0	-0.1	-1.0	0.9
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.3	-0.1	-1.0	-1.8
High blood pressure (siblings)	1.0	1.4	2.2	1.3	1.5	-0.6
Forced vital capacity (FVC), Best measure	0.5	1.7	4.5	0.7	0.2	2.1
Body fat percentage	0.0	0.0	0.1	-0.2	-0.0	-0.3
Leg fat percentage (right)	0.3	1.0	1.6	0.9	1.3	-0.8
Arm fat-free mass (right)	0.3	1.8	2.5	-0.7	-1.6	1.5
Exposure to tobacco smoke outside home	0.3	0.4	0.4	-0.5	-0.6	0.6
Comparative body size at age 10	0.8	2.2	5.0	-2.2	-1.1	0.6
Number of full brothers	1.1	1.3	2.5	1.2	1.6	-0.1
Worry too long after embarrassment	1.0	1.6	2.4	1.1	1.6	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	3.6	1.9	1.6	-0.2
Wheeze or whistling in the chest in last year	1.5	2.6	4.3	-1.8	-2.1	-0.5
Number of children fathered	0.1	0.1	0.3	0.6	0.2	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.3	0.4	0.5	-0.1
Age at first live birth	0.9	1.6	3.8	0.5	0.9	-1.9
Pulse wave peak to peak time	0.1	0.2	0.2	0.4	0.4	0.4
Health satisfaction	2.0	2.6	4.1	-1.6	-2.0	1.0
Shortness of breath walking on level ground	0.2	0.2	0.5	-0.1	-0.3	-0.7
Qualifications: College or University degree	0.1	0.4	0.6	-0.7	-0.8	0.3
Eye problems/disorders: None of the above	0.2	0.2	0.3	0.3	0.3	-0.6
Mouth/teeth dental problems: Loose teeth	1.4	1.6	2.8	-0.7	-1.3	1.7
Emphysema/chronic bronchitis	0.0	0.1	0.1	0.1	0.1	0.4
Medication for pain relief, constipation, heartburn	0.3	0.5	1.5	-1.2	-0.2	-0.1
Neck or shoulder pain in last month	5.5	7.8	14.7	-2.9	-3.8	-0.3
Medication: Blood pressure	0.7	1.2	3.3	-0.3	-0.4	1.8
Angina (self-reported)	0.3	0.4	1.2	1.1	0.3	-0.2
Migraine (self-reported)	4.4	5.4	9.0	-2.5	-3.0	-0.9
Medication: Ibuprofen	1.3	1.6	3.4	-1.0	-1.8	-0.6
Medication: Allopurinol	6.4	8.5	23.4	1.1	0.9	-4.8
Medication: Omeprazole	1.1	1.4	3.4	1.8	0.7	-0.4
Medication: Seretide 50 evohaler	0.9	1.0	1.2	-1.1	-1.1	0.8
Mean time to correctly identify matches	0.0	0.1	0.2	0.1	-0.3	-0.4
Heart disease (mother)	0.3	0.3	0.5	-0.7	0.1	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.4	0.6	0.1	-1.2
Whole body fat mass	0.0	0.2	0.3	-0.4	-0.5	0.5
Leg fat mass (right)	0.0	0.0	0.0	-0.1	-0.2	0.2
Arm predicted mass (right)	0.5	2.8	4.1	-1.0	-1.8	2.0
Pulse rate, automated reading	0.6	2.0	3.9	2.0	1.1	1.0
Alcohol intake frequency.	1.0	2.4	4.1	-1.4	-0.9	-2.0
Comparative height size at age 10	1.4	7.9	22.3	0.6	-1.1	4.7
Number of full sisters	1.1	1.3	3.4	1.8	0.6	-0.3
Suffer from ‘nerves’	1.1	1.8	2.6	1.6	1.5	0.6
Overall health rating	2.0	4.2	7.3	-1.3	-1.9	2.7
Chest pain or discomfort	0.6	0.9	1.4	-1.2	-0.8	0.7
Had major operations	1.6	1.9	3.8	-1.1	-0.9	2.0
Age at last live birth	1.1	1.6	2.9	0.9	1.0	-1.7
Family relationship satisfaction	1.4	1.7	2.4	-1.5	-1.5	-0.7
Leg pain on walking	0.0	0.0	0.1	-0.1	-0.3	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	-0.1	-0.2	-0.1
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.2	1.5	1.2	0.9
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.4	-0.4	-0.4	1.2
Medication: Aspirin	1.1	1.5	1.8	1.4	1.1	1.2
Supplements: Vitamin C	0.1	0.1	0.1	0.3	0.4	0.1
Knee pain experienced in last month	0.2	0.3	0.7	0.0	-0.4	0.8
Hypertension (Self-reported)	0.8	2.1	6.1	0.4	0.3	2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	5.5	1.3	0.6	2.3
Illnesses of father: Heart disease	1.2	1.7	2.9	-1.7	-1.0	-1.0
Illnesses of siblings: Diabetes	0.6	0.7	2.0	-0.2	0.4	-1.4
Smoking status: Previous	0.0	0.0	0.0	0.1	-0.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	3.8	2.0	1.1	1.7
Whole body fat-free mass	0.9	5.4	7.8	-1.8	-2.8	2.2
Leg fat-free mass (right)	1.5	8.1	13.3	-2.8	-3.6	1.9
Arm fat percentage (left)	0.2	0.9	1.9	-1.4	-0.8	-0.2
Average weekly red wine intake	0.1	0.1	0.2	0.5	-0.1	0.4
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.4	-1.6	-0.8	0.1
Mood swings	0.4	0.7	2.0	0.4	0.2	1.4
Loneliness, isolation	0.1	0.1	0.3	-0.0	0.1	0.6
Long-standing illness, disability or infirmity	1.0	1.6	2.4	-1.5	-1.5	-0.3
Ever had bowel cancer screening	0.6	0.7	1.7	-0.5	-0.3	-1.3
Diabetes diagnosed by doctor	0.2	0.3	0.6	-0.8	-0.3	0.6
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	2.7	-1.5	-1.4	-1.6
Friendships satisfaction	2.0	2.5	4.4	1.1	1.3	-2.1
Qualifications: nursing, teaching	1.0	1.6	3.5	-1.0	-0.5	-1.9
Commuting to job workplace: Walk	1.1	1.2	1.9	-1.4	-1.2	-0.4
Eye problems/disorders: Cataract	1.0	1.1	3.2	-0.2	-0.4	1.8
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.2	0.4	0.5	-0.5
Medication for cholesterol	0.6	0.9	2.5	-0.1	0.4	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.1	0.2	0.2	-1.0
Back pain experienced in last month	0.1	0.2	0.3	-0.0	-0.5	0.4
Mineral and other dietary supplements	0.9	1.2	2.3	1.5	1.1	-0.4
Breast cancer (self-reported)	0.5	0.6	1.6	0.1	0.3	-1.3
Asthma (self-reported)	2.0	3.9	7.0	-2.1	-2.6	0.4
Osteoporosis (self-reported)	0.1	0.1	0.2	0.3	-0.1	0.5
Osteoarthritis (self-reported)	6.8	8.8	12.7	-3.1	-3.6	2.0
Medication: Aspirin	0.7	1.0	1.2	1.1	1.0	0.8
Medication: Gliclazide	0.3	0.4	0.9	0.2	-0.3	-1.0
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	0.3	0.2	0.0
Smoking status: Current	0.8	1.3	1.8	1.3	1.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.3	-0.1	0.2	1.8
Whole body water mass	1.0	5.4	8.0	-1.9	-2.8	2.2
Leg predicted mass (right)	1.6	8.3	13.6	-2.8	-3.7	1.9
Arm fat mass (left)	0.5	1.9	2.8	-1.7	-1.6	0.6
Number of self-reported non-cancer illnesses	1.4	2.4	3.6	-1.0	-1.9	1.6
Average weekly champagne plus white wine intake	3.3	4.5	7.8	2.3	2.8	-0.7
Miserableness	0.1	0.1	0.2	0.3	0.4	-0.3
Guilty feelings	0.1	0.2	0.4	-0.0	0.4	-0.6
Wears glasses or contact lenses	0.8	0.9	1.7	-0.8	-0.6	1.3
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.2	0.3	0.5
Hearing aid user	0.8	0.9	2.0	-1.4	-0.9	0.3
Mother’s age at death	0.5	0.6	1.2	0.1	0.8	-1.1
Financial situation satisfaction	0.1	0.1	0.2	-0.1	-0.5	0.0
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.7	-0.3	-0.2	1.3
Commuting to job workplace: Public transport	0.4	0.5	1.2	0.4	0.1	-1.1
Eye problems/disorders: Glaucoma	1.4	1.7	2.7	1.6	1.5	0.4
Medication: Blood pressure	0.4	0.9	2.1	0.7	0.2	1.4
Pain type(s) experienced in last month: Hip pain	2.4	3.1	6.4	-0.5	-1.6	2.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.3	-1.2	-0.4	0.1
High cholesterol (Self-reported)	0.1	0.1	0.4	0.3	0.0	0.6
Medication: Bendroflumethiazide	1.2	1.9	3.6	1.1	0.8	1.9
Medication: Paracetamol	1.3	2.0	4.8	2.2	1.1	-0.3
Medication: Lisinopril	0.1	0.2	0.5	-0.0	0.1	0.7
Medication: Atorvastatin	0.1	0.2	0.5	0.7	-0.2	-0.2
Illnesses of father: High blood pressure	0.6	0.8	1.1	0.9	1.0	-0.6
Alcohol drinker status: Never	2.1	2.5	4.4	1.7	2.1	0.1
Ever smoked	0.2	0.3	0.3	0.6	0.6	-0.6
Basal metabolic rate	0.8	4.6	6.5	-1.6	-2.5	2.2
Leg fat percentage (left)	0.1	0.2	0.4	0.1	0.5	-0.6
Arm fat-free mass (left)	0.6	2.9	4.3	-1.1	-2.1	1.8
Number of operations (self-reported)	0.4	0.5	0.7	-0.8	-0.9	-0.5
Average weekly beer plus cider intake	0.3	0.4	1.0	-0.1	-1.0	0.6
Irritability	2.1	3.5	5.2	2.3	2.1	0.9
Risk taking	0.3	0.5	1.3	0.4	0.1	-1.1
Ever had prostate specific antigen (PSA) test	1.3	1.5	1.7	1.2	1.2	1.3
Fractured/broken bones in last 5 years	1.3	1.7	2.3	1.5	1.5	0.8
Age started oral contraceptive pill	0.3	0.3	0.7	-0.9	-0.3	-0.4
Diastolic blood pressure, automated reading	0.1	0.2	0.5	-0.1	-0.5	0.7
Ever depressed for a whole week	0.5	0.6	0.9	0.4	1.0	-0.8
Unable to work because of sickness or disability	3.7	4.8	7.6	-2.8	-2.3	1.3
Commuting to job workplace: Cycle	2.7	3.2	5.0	-2.2	-1.8	-1.2
Myopia	0.7	1.0	2.9	0.0	-0.2	-1.7
Vascular/heart problems diagnosed by doctor	0.8	2.1	6.1	-0.3	-0.2	-2.5
Cholesterol lowering medication	1.9	2.8	4.7	-1.5	-2.2	1.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	0.9	-0.4	0.5
Pain experienced in last month	1.1	1.9	2.9	0.8	1.7	-1.4
Supplements: Calcium	0.2	0.3	0.5	0.4	0.7	0.3
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	0.4	0.0	0.6
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	-0.1	-0.2	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.1	-0.1	0.5
Heart disease (siblings)	1.3	1.6	3.2	0.8	1.8	-0.9
Alcohol drinker status: Previous	0.7	0.8	2.2	-0.5	-0.1	-1.5
Pack years of smoking	0.2	0.3	0.3	-0.6	-0.5	-0.4
Impedance of whole body	1.8	9.2	16.2	4.0	3.4	-0.4
Leg fat mass (left)	0.1	0.4	0.5	-0.7	-0.7	0.3
Arm predicted mass (left)	0.6	3.2	4.3	-1.0	-2.1	2.1