TWAS hub - TMEM171

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.383	0.0532	0.00000	0.287	0.198	0.272	0.282	0.281	4.4e-37	7.6e-25	6.3e-35	2e-36	2.9e-36
2	TCGA	Colon Adenocarcinoma	0.161	0.0620	0.00037	0.054	0.055	0.053	NA	0.069	4.6e-04	4.1e-04	5.0e-04	NA	8.0e-05
3	TCGA	Thyroid Carcinoma	0.086	0.0390	0.00190	0.049	0.016	0.025	NA	0.041	1.4e-05	8.9e-03	1.7e-03	NA	7.3e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Hypothyroidism (self reported)	7.8	17.9	27.4	-5.2	-5.1	0.8
Gout (self-reported)	7.8	10.7	31.9	-0.2	0.3	-5.6
Osteoarthritis (self-reported)	6.8	8.8	12.7	-3.1	-3.6	2.0
Medication: Allopurinol	6.4	8.5	23.4	1.1	0.9	-4.8
Hypothyroidism/myxoedema (self-reported)	5.7	11.2	15.5	-3.9	-3.7	2.1
Neck or shoulder pain in last month	5.5	7.8	14.7	-2.9	-3.8	-0.3
Supplements: Glucosamine	5.2	6.8	10.2	-3.1	-3.2	1.0
Birth weight of first child	4.6	8.3	14.4	-3.8	-3.2	0.7
Migraine (self-reported)	4.4	5.4	9.0	-2.5	-3.0	-0.9
Length of working week for main job	4.1	4.6	6.6	-1.9	-2.6	1.9
Alzheimer’s Disease (in father)	4.0	4.4	5.4	2.3	2.2	-1.7
Impedance of leg (right)	3.8	18.2	29.4	5.4	5.0	-0.6
Medication: Levothyroxine sodium	3.8	6.4	10.3	-3.2	-2.7	1.2
Unable to work because of sickness or disability	3.7	4.8	7.6	-2.8	-2.3	1.3
Average weekly champagne plus white wine intake	3.3	4.5	7.8	2.3	2.8	-0.7
Serious illness, injury or assault of a close relative in last 2 years	3.0	3.4	6.0	-1.8	-1.1	-2.5
HbA1C	2.8	3.1	4.5	-1.6	-1.5	2.1
Ulcerative Colitis (UC)	2.7	5.1	7.7	2.8	2.8	-0.1
Crohns Disease (2012)	2.7	4.4	6.2	2.5	1.8	-1.9
Impedance of leg (left)	2.7	13.0	21.3	4.6	4.2	-0.6
Commuting to job workplace: Cycle	2.7	3.2	5.0	-2.2	-1.8	-1.2
Schizophrenia (2014)	2.5	5.5	9.4	1.7	2.1	-3.1
Hayfever/allergic rhinitis (self-reported)	2.5	3.3	5.5	-2.1	-2.3	0.2
Pain type(s) experienced in last month: Hip pain	2.4	3.1	6.4	-0.5	-1.6	2.5
Schizophrenia (2018)	2.3	4.7	5.4	2.2	2.3	-2.0
Irritable Bowel Disease (IBD)	2.3	5.4	8.9	3.0	2.5	-1.1
HDL Cholesterol	2.2	3.7	10.8	-0.4	-0.3	-3.3
Glaucoma (self-reported)	2.2	2.5	4.6	2.2	1.7	0.5
Bipolar Disorder or Schizophrenia	2.1	5.2	6.7	2.6	2.4	-1.9
Mean Putamen Volume	2.1	2.4	3.4	1.8	1.8	0.8
Medication: Simvastatin	2.1	3.1	3.6	-1.9	-1.9	1.5
Medication: Ventolin 100micrograms inhaler	2.1	2.7	3.2	-1.8	-1.8	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	5.5	1.3	0.6	2.3
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	2.7	-1.5	-1.4	-1.6
Alcohol drinker status: Never	2.1	2.5	4.4	1.7	2.1	0.1
Irritability	2.1	3.5	5.2	2.3	2.1	0.9
Breast Cancer	2.0	4.8	6.5	-2.5	-2.5	1.2
LDL Cholesterol	2.0	3.1	4.4	2.1	2.1	0.8
Ever unenthusiastic/disinterested for a whole week	2.0	2.5	3.2	1.8	1.8	-1.1
Health satisfaction	2.0	2.6	4.1	-1.6	-2.0	1.0
Overall health rating	2.0	4.2	7.3	-1.3	-1.9	2.7
Friendships satisfaction	2.0	2.5	4.4	1.1	1.3	-2.1
Asthma (self-reported)	2.0	3.9	7.0	-2.1	-2.6	0.4
Asthma	1.9	3.7	6.7	-2.1	-2.6	0.3
Cholesterol lowering medication	1.9	2.8	4.7	-1.5	-2.2	1.2
Ulcerative Colitis	1.8	2.7	4.6	2.1	1.8	-0.5
Illnesses of siblings	1.8	2.5	3.6	-1.4	-1.9	1.4
Impedance of whole body	1.8	9.2	16.2	4.0	3.4	-0.4
Heel T-Score	1.7	13.7	17.7	-3.9	-2.9	-4.2
Average weekly fortified wine intake	1.6	1.9	3.4	-1.8	-1.0	-1.2
Maternal smoking around birth	1.6	2.3	3.2	-1.6	-1.8	1.1
Relative age voice broke	1.6	2.4	4.3	1.4	2.1	-0.9
Falls in the last year	1.6	2.1	6.0	0.1	-0.6	2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	3.6	1.9	1.6	-0.2
Had major operations	1.6	1.9	3.8	-1.1	-0.9	2.0
Leg predicted mass (right)	1.6	8.3	13.6	-2.8	-3.7	1.9
Systolic blood pressure, automated reading	1.5	4.3	7.8	-2.8	-2.2	0.5
Medication: Ramipril	1.5	1.9	2.7	1.6	1.3	1.1
Wheeze or whistling in the chest in last year	1.5	2.6	4.3	-1.8	-2.1	-0.5
Leg fat-free mass (right)	1.5	8.1	13.3	-2.8	-3.6	1.9
Alzheimer’s Disease (including proxy)	1.4	2.1	3.6	1.9	1.2	-1.1
Ever highly irritable/argumentative for 2 days	1.4	1.6	1.7	1.3	1.2	-1.3
Mouth/teeth dental problems: Loose teeth	1.4	1.6	2.8	-0.7	-1.3	1.7
Comparative height size at age 10	1.4	7.9	22.3	0.6	-1.1	4.7
Family relationship satisfaction	1.4	1.7	2.4	-1.5	-1.5	-0.7
Number of self-reported non-cancer illnesses	1.4	2.4	3.6	-1.0	-1.9	1.6
Eye problems/disorders: Glaucoma	1.4	1.7	2.7	1.6	1.5	0.4
Lung FEV1/FVC ratio	1.3	6.6	11.1	2.7	3.3	-1.1
Pain all over the body in last month	1.3	1.4	2.3	-1.3	-1.5	0.2
Alcohol intake versus 10 years previously	1.3	2.0	3.0	-1.7	-1.5	-0.9
Tense / ‘highly strung’	1.3	2.1	3.1	1.8	1.6	0.8
Medication: Ibuprofen	1.3	1.6	3.4	-1.0	-1.8	-0.6
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.2	1.5	1.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	3.8	2.0	1.1	1.7
Medication: Paracetamol	1.3	2.0	4.8	2.2	1.1	-0.3
Ever had prostate specific antigen (PSA) test	1.3	1.5	1.7	1.2	1.2	1.3
Fractured/broken bones in last 5 years	1.3	1.7	2.3	1.5	1.5	0.8
Heart disease (siblings)	1.3	1.6	3.2	0.8	1.8	-0.9
Schizophrenia vs Biploar Disorder	1.2	1.6	3.5	-0.1	1.1	-1.9
Primary Biliary Cirrhosis	1.2	1.7	2.1	-1.4	-1.4	-1.0
Frequency of depressed mood in last 2 weeks	1.2	1.6	2.7	1.4	1.7	0.5
Townsend deprivation index at recruitment	1.2	1.7	4.0	1.0	0.1	2.0
Hearing difficulty/problems with background noise	1.2	2.0	3.5	1.5	1.9	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.0	-0.9	-1.7	-0.7
Illnesses of mother	1.2	1.4	4.2	-0.0	0.3	2.0
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.3	-0.1	-1.0	-1.8
Illnesses of father: Heart disease	1.2	1.7	2.9	-1.7	-1.0	-1.0
Medication: Bendroflumethiazide	1.2	1.9	3.6	1.1	0.8	1.9
Leg fat-free mass (left)	1.1	5.8	9.2	-2.2	-3.0	1.8
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	1.9	-1.4	-1.4	-0.4
Leg predicted mass (left)	1.1	5.8	9.5	-2.2	-3.1	1.7
Lung cancer (father)	1.1	1.3	1.8	1.3	1.1	0.9
Hair/balding pattern: Pattern 4	1.1	2.7	5.4	1.6	2.3	0.2
Number of full brothers	1.1	1.3	2.5	1.2	1.6	-0.1
Medication: Omeprazole	1.1	1.4	3.4	1.8	0.7	-0.4
Number of full sisters	1.1	1.3	3.4	1.8	0.6	-0.3
Suffer from ‘nerves’	1.1	1.8	2.6	1.6	1.5	0.6
Age at last live birth	1.1	1.6	2.9	0.9	1.0	-1.7
Medication: Aspirin	1.1	1.5	1.8	1.4	1.1	1.2
Commuting to job workplace: Walk	1.1	1.2	1.9	-1.4	-1.2	-0.4
Pain experienced in last month	1.1	1.9	2.9	0.8	1.7	-1.4
Allergy or Eczema	1.0	2.7	4.2	-2.0	-1.9	0.5
Supplements: Zinc	1.0	1.1	1.7	1.2	1.3	-0.0
Hair/balding pattern: Pattern 2	1.0	1.3	3.5	-0.4	-0.4	-1.9
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	4.0	0.2	0.9	-2.0
High blood pressure (siblings)	1.0	1.4	2.2	1.3	1.5	-0.6
Worry too long after embarrassment	1.0	1.6	2.4	1.1	1.6	1.1
Alcohol intake frequency.	1.0	2.4	4.1	-1.4	-0.9	-2.0
Long-standing illness, disability or infirmity	1.0	1.6	2.4	-1.5	-1.5	-0.3
Qualifications: nursing, teaching	1.0	1.6	3.5	-1.0	-0.5	-1.9
Eye problems/disorders: Cataract	1.0	1.1	3.2	-0.2	-0.4	1.8
Whole body water mass	1.0	5.4	8.0	-1.9	-2.8	2.2
Rheumatoid Arthritis	0.9	1.3	1.5	-1.2	-1.2	1.0
Current tobacco smoking	0.9	1.5	2.1	1.4	1.4	-0.6
Chronic bronchitis/emphysema (father)	0.9	1.1	1.5	-0.8	-1.0	1.2
Qualifications: None of the above	0.9	1.9	3.7	1.0	1.0	1.9
Pulse rate	0.9	1.6	2.7	1.4	1.6	0.2
Mouth/teeth dental problems: Dentures	0.9	1.5	3.6	-0.6	-0.8	1.9
Age at first live birth	0.9	1.6	3.8	0.5	0.9	-1.9
Medication: Seretide 50 evohaler	0.9	1.0	1.2	-1.1	-1.1	0.8
Whole body fat-free mass	0.9	5.4	7.8	-1.8	-2.8	2.2
Mineral and other dietary supplements	0.9	1.2	2.3	1.5	1.1	-0.4
Crohns Disease (2017)	0.8	1.7	2.3	1.5	0.8	-1.5
Triglycerides	0.8	1.3	3.3	-0.1	0.8	1.8
Systolic Blood Pressure	0.8	4.1	7.2	-2.7	-2.1	0.8
Respiratory disease	0.8	1.7	3.6	-1.2	-1.9	0.2
Number of treatments/medications taken	0.8	1.4	2.6	-1.0	-1.6	0.8
Average weekly spirits intake	0.8	1.0	1.8	1.2	1.3	0.1
Relative age of first facial hair	0.8	1.6	2.3	1.3	1.5	0.9
High blood pressure	0.8	2.2	6.2	0.5	0.5	2.5
Nervous feelings	0.8	1.4	1.8	1.3	1.0	1.2
Happiness	0.8	0.9	1.6	0.5	1.0	-1.3
Peak expiratory flow (PEF)	0.8	1.9	5.2	0.1	0.6	2.3
Medication: Paracetamol	0.8	1.2	2.9	1.7	0.7	-0.5
Comparative body size at age 10	0.8	2.2	5.0	-2.2	-1.1	0.6
Hypertension (Self-reported)	0.8	2.1	6.1	0.4	0.3	2.5
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.4	-1.6	-0.8	0.1
Smoking status: Current	0.8	1.3	1.8	1.3	1.3	-0.6
Wears glasses or contact lenses	0.8	0.9	1.7	-0.8	-0.6	1.3
Hearing aid user	0.8	0.9	2.0	-1.4	-0.9	0.3
Basal metabolic rate	0.8	4.6	6.5	-1.6	-2.5	2.2
Vascular/heart problems diagnosed by doctor	0.8	2.1	6.1	-0.3	-0.2	-2.5
Ever had hysterectomy (womb removed)	0.7	0.8	1.4	-1.0	-1.2	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	2.7	-1.3	-0.9	-1.6
Trunk fat-free mass	0.7	4.2	6.5	-1.2	-2.2	2.6
Impedance of arm (left)	0.7	3.1	5.5	2.3	1.9	0.4
Trunk predicted mass	0.7	4.2	6.5	-1.2	-2.2	2.5
Standing height	0.7	6.9	16.7	1.9	-0.6	4.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	3.2	0.0	0.2	-1.8
Medication: Blood pressure	0.7	1.2	3.3	-0.3	-0.4	1.8
Medication: Aspirin	0.7	1.0	1.2	1.1	1.0	0.8
Myopia	0.7	1.0	2.9	0.0	-0.2	-1.7
Alcohol drinker status: Previous	0.7	0.8	2.2	-0.5	-0.1	-1.5
Bipolar Disorder (2018)	0.6	1.0	2.0	1.4	0.9	-0.5
Bipolar Disorder (2011)	0.6	0.6	1.4	1.2	0.0	0.5
Body Mass Index (BMI) (2010)	0.6	0.8	2.2	-0.4	0.2	1.5
Hearing difficulty/problems: Yes	0.6	0.9	2.0	0.2	0.8	-1.4
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.2	-0.8	-0.3	1.1
Fed-up feelings	0.6	1.1	1.7	0.8	1.3	-0.9
Age when periods started (menarche)	0.6	1.5	3.3	0.9	0.7	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	1.8	-1.3	-0.6	-1.3
Multivitamins +/- minerals	0.6	0.8	1.0	0.9	0.8	-1.0
Sitting height	0.6	4.2	10.4	-0.2	-1.5	3.2
Had other major operations	0.6	0.7	1.9	-0.1	-0.5	-1.4
Mouth/teeth dental problems	0.6	0.8	1.8	0.5	0.7	-1.3
Allergy	0.6	1.4	1.7	0.8	1.3	-1.3
Diabetes (self-reported)	0.6	0.9	1.5	-1.2	-1.0	0.5
Prospective memory result	0.6	0.7	1.1	1.1	1.0	-0.1
Medication: Amlodipine	0.6	0.9	1.2	-1.1	-0.7	1.0
Pulse rate, automated reading	0.6	2.0	3.9	2.0	1.1	1.0
Chest pain or discomfort	0.6	0.9	1.4	-1.2	-0.8	0.7
Illnesses of siblings: Diabetes	0.6	0.7	2.0	-0.2	0.4	-1.4
Ever had bowel cancer screening	0.6	0.7	1.7	-0.5	-0.3	-1.3
Medication for cholesterol	0.6	0.9	2.5	-0.1	0.4	-1.6
Illnesses of father: High blood pressure	0.6	0.8	1.1	0.9	1.0	-0.6
Arm fat-free mass (left)	0.6	2.9	4.3	-1.1	-2.1	1.8
Arm predicted mass (left)	0.6	3.2	4.3	-1.0	-2.1	2.1
Ovarian Cancer	0.5	0.6	1.1	0.6	0.7	-1.1
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.3	-0.5	-0.2	-1.1
Blood White Count	0.5	3.9	10.7	1.0	-0.2	-3.3
Height	0.5	10.6	24.9	2.0	-1.7	5.0
Vitamin and mineral supplements	0.5	0.7	0.9	-1.0	-1.0	0.5
Medication: Metformin	0.5	0.6	1.3	0.7	1.2	0.2
Diabetes (mother)	0.5	0.6	1.4	0.6	-0.1	-1.2
Taking other prescription medications	0.5	0.7	1.8	-0.7	-1.3	0.1
Stomach or abdominal pain in last month	0.5	0.6	0.8	0.8	0.9	0.7
Had menopause	0.5	0.6	1.2	-1.1	-0.7	0.3
Fluid intelligence score	0.5	1.0	1.3	0.9	1.1	-1.0
Impedance of arm (right)	0.5	2.5	4.5	2.1	1.6	0.6
Worrier / anxious feelings	0.5	0.9	1.7	0.6	1.3	-0.8
Depression (self-reported)	0.5	0.6	1.0	0.8	1.0	0.2
Pulse wave reflection index	0.5	0.6	1.4	0.6	-0.4	-1.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	0.7	0.8	0.8	-0.7
Forced vital capacity (FVC), Best measure	0.5	1.7	4.5	0.7	0.2	2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.4	0.6	0.1	-1.2
Arm predicted mass (right)	0.5	2.8	4.1	-1.0	-1.8	2.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.4	-0.4	-0.4	1.2
Breast cancer (self-reported)	0.5	0.6	1.6	0.1	0.3	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.3	-0.1	0.2	1.8
Arm fat mass (left)	0.5	1.9	2.8	-1.7	-1.6	0.6
Mother’s age at death	0.5	0.6	1.2	0.1	0.8	-1.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.7	-0.3	-0.2	1.3
Ever depressed for a whole week	0.5	0.6	0.9	0.4	1.0	-0.8
Neuroticism (Nagel 2018)	0.4	1.0	1.7	1.1	1.3	0.4
Worry (Nagel 2018)	0.4	0.8	1.3	1.2	0.9	0.5
Fasting Glucose	0.4	0.5	0.9	-0.3	-0.7	0.9
Blood Platelet Count	0.4	4.5	7.8	-2.4	-0.3	-2.8
Blood Red Count	0.4	4.0	7.6	2.1	2.8	-0.3
Smoking Status	0.4	1.0	1.6	1.3	0.9	-0.8
Lung FVC	0.4	2.1	2.9	-1.6	-0.8	1.7
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	0.9	-0.9	-0.9	-0.2
Medication for hormone replacement therapy	0.4	0.4	1.3	-0.0	-0.2	-1.1
Diabetes (father)	0.4	0.4	0.9	-1.0	-0.4	-0.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.7	-0.8	-0.6	-0.2
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.2	-1.1	-1.1	0.2
High blood pressure (mother)	0.4	0.5	1.0	-1.0	-0.5	-0.5
Body mass index (BMI)	0.4	1.7	3.4	-1.8	-1.3	-0.3
Number of incorrect matches in round	0.4	0.6	1.1	0.8	0.1	1.0
Financial difficulties in last 2 years	0.4	0.6	1.2	0.7	0.2	-1.1
Neuroticism score	0.4	0.8	0.9	0.8	0.9	0.9
Weight	0.4	1.9	2.6	-0.9	-1.6	1.6
Noisy workplace	0.4	0.5	1.4	-0.0	0.0	1.2
Arm fat mass (right)	0.4	1.8	2.5	-1.6	-1.5	0.8
Mood swings	0.4	0.7	2.0	0.4	0.2	1.4
Commuting to job workplace: Public transport	0.4	0.5	1.2	0.4	0.1	-1.1
Medication: Blood pressure	0.4	0.9	2.1	0.7	0.2	1.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.3	-1.2	-0.4	0.1
Number of operations (self-reported)	0.4	0.5	0.7	-0.8	-0.9	-0.5
Cardiovascular Disease	0.3	1.1	1.6	1.3	1.1	0.7
Severe depression (siblings)	0.3	0.4	0.7	-0.5	-0.5	-0.8
Forced vital capacity (FVC)	0.3	1.0	2.9	0.2	0.1	1.7
Arm fat percentage (right)	0.3	1.2	2.4	-1.5	-1.1	0.0
Hip circumference	0.3	1.1	2.0	-1.1	-1.4	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.7	0.7	0.5	0.9
Medication: Cholesterol lowering	0.3	0.4	0.6	0.7	0.7	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.3	1.0	0.9	1.1
Breastfed as a baby	0.3	0.4	0.7	0.7	0.8	0.1
Birth weight	0.3	0.6	1.0	-0.1	-1.0	0.9
Leg fat percentage (right)	0.3	1.0	1.6	0.9	1.3	-0.8
Arm fat-free mass (right)	0.3	1.8	2.5	-0.7	-1.6	1.5
Exposure to tobacco smoke outside home	0.3	0.4	0.4	-0.5	-0.6	0.6
Medication for pain relief, constipation, heartburn	0.3	0.5	1.5	-1.2	-0.2	-0.1
Angina (self-reported)	0.3	0.4	1.2	1.1	0.3	-0.2
Heart disease (mother)	0.3	0.3	0.5	-0.7	0.1	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.1	0.2	0.2	-1.0
Medication: Gliclazide	0.3	0.4	0.9	0.2	-0.3	-1.0
Average weekly beer plus cider intake	0.3	0.4	1.0	-0.1	-1.0	0.6
Risk taking	0.3	0.5	1.3	0.4	0.1	-1.1
Age started oral contraceptive pill	0.3	0.3	0.7	-0.9	-0.3	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	0.9	-0.4	0.5
Depression (Nagel 2018)	0.2	0.3	0.6	0.8	0.5	-0.3
Major Depression (MDD)	0.2	0.2	0.4	0.6	0.2	-0.6
Reaction Time	0.2	0.5	1.1	1.0	0.4	-0.4
Lupus	0.2	0.3	0.5	-0.6	-0.7	0.0
Neuroticism (2016)	0.2	0.3	0.7	-0.8	-0.6	-0.0
Blood Eosinophil Count	0.2	1.8	4.1	2.0	0.8	0.8
Waist Hip Ratio (WHR)	0.2	1.0	1.7	1.1	0.2	1.3
Neuroticism	0.2	0.6	1.6	-0.2	-0.0	1.3
Chronotype (morning person)	0.2	0.5	1.2	1.1	0.5	0.3
Angina	0.2	0.3	0.9	0.9	0.1	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	0.8	0.2	0.4
Qualifications: CSEs or equivalent	0.2	0.3	0.5	0.7	0.6	0.0
Serious illness, injury or assault to yourself	0.2	0.2	0.3	-0.5	-0.5	-0.3
Waist circumference	0.2	0.7	1.2	-0.4	-0.9	1.1
Alcohol usually taken with meals	0.2	0.3	1.0	0.2	1.0	0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	-0.3	-0.2	0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	0.8	0.8	0.9	0.7
Medication: Lansoprazole	0.2	0.2	0.4	-0.3	-0.7	0.3
Headache pain in last month	0.2	0.4	0.7	-0.4	-0.6	-0.8
Shortness of breath walking on level ground	0.2	0.2	0.5	-0.1	-0.3	-0.7
Eye problems/disorders: None of the above	0.2	0.2	0.3	0.3	0.3	-0.6
Knee pain experienced in last month	0.2	0.3	0.7	0.0	-0.4	0.8
Arm fat percentage (left)	0.2	0.9	1.9	-1.4	-0.8	-0.2
Diabetes diagnosed by doctor	0.2	0.3	0.6	-0.8	-0.3	0.6
Ever smoked	0.2	0.3	0.3	0.6	0.6	-0.6
Supplements: Calcium	0.2	0.3	0.5	0.4	0.7	0.3
Pack years of smoking	0.2	0.3	0.3	-0.6	-0.5	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	0.5	0.7	-0.1
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.3	-0.5	0.1
Age at First Birth	0.1	0.2	0.4	0.4	0.6	-0.3
BMI	0.1	0.3	0.8	-0.9	0.0	-0.5
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	-0.4	0.6	0.1
Hair Pigment	0.1	1.6	3.1	1.8	0.4	1.3
Tanning	0.1	1.5	3.5	-0.8	-1.9	0.6
Hand grip strength (left)	0.1	0.3	0.9	-0.9	0.1	0.0
Sensitivity / hurt feelings	0.1	0.2	0.4	0.0	0.7	0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	-0.5	-0.4	0.2
Medication: Co-codamol	0.1	0.1	0.3	-0.0	-0.2	0.5
Pack years adult smoking proportion	0.1	0.2	0.2	-0.4	-0.5	-0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.2	0.4	0.4	-0.4
Trunk fat mass	0.1	0.2	0.3	-0.3	-0.5	0.6
Time employed in main current job	0.1	0.2	0.3	-0.5	-0.3	-0.3
Father’s age at death	0.1	0.2	0.2	-0.5	-0.4	-0.4
Number of live births	0.1	0.1	0.2	-0.4	-0.4	0.3
Pulse wave Arterial Stiffness index	0.1	0.2	0.4	-0.4	-0.6	-0.1
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.1	-0.3	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.5	0.0	0.6
Blood clot in the leg (DVT)	0.1	0.1	0.4	0.1	-0.2	0.6
Number of children fathered	0.1	0.1	0.3	0.6	0.2	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.3	0.4	0.5	-0.1
Pulse wave peak to peak time	0.1	0.2	0.2	0.4	0.4	0.4
Qualifications: College or University degree	0.1	0.4	0.6	-0.7	-0.8	0.3
Supplements: Vitamin C	0.1	0.1	0.1	0.3	0.4	0.1
Average weekly red wine intake	0.1	0.1	0.2	0.5	-0.1	0.4
Loneliness, isolation	0.1	0.1	0.3	-0.0	0.1	0.6
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.2	0.4	0.5	-0.5
Back pain experienced in last month	0.1	0.2	0.3	-0.0	-0.5	0.4
Osteoporosis (self-reported)	0.1	0.1	0.2	0.3	-0.1	0.5
Miserableness	0.1	0.1	0.2	0.3	0.4	-0.3
Guilty feelings	0.1	0.2	0.4	-0.0	0.4	-0.6
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.2	0.3	0.5
Financial situation satisfaction	0.1	0.1	0.2	-0.1	-0.5	0.0
High cholesterol (Self-reported)	0.1	0.1	0.4	0.3	0.0	0.6
Medication: Lisinopril	0.1	0.2	0.5	-0.0	0.1	0.7
Medication: Atorvastatin	0.1	0.2	0.5	0.7	-0.2	-0.2
Leg fat percentage (left)	0.1	0.2	0.4	0.1	0.5	-0.6
Diastolic blood pressure, automated reading	0.1	0.2	0.5	-0.1	-0.5	0.7
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	0.4	0.0	0.6
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.1	-0.1	0.5
Leg fat mass (left)	0.1	0.4	0.5	-0.7	-0.7	0.3
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	-0.1	0.3	0.1
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.1	0.0	0.3	-0.1
Prostate Cancer	0.0	0.0	0.0	0.1	0.0	-0.2
Coronary Artery Disease (CAD)	0.0	0.1	0.1	0.3	0.3	-0.1
Trunk fat percentage	0.0	0.0	0.0	-0.2	-0.2	0.1
Hand grip strength (right)	0.0	0.1	0.2	-0.1	0.5	-0.1
Medication: Atenolol	0.0	0.0	0.1	0.3	0.1	0.0
Past tobacco smoking	0.0	0.1	0.1	-0.4	-0.2	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	-0.0	-0.2	0.1
Heart attack	0.0	0.0	0.0	-0.1	-0.1	0.0
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.1	-0.2	0.1	-0.2
Loud music exposure frequency	0.0	0.0	0.0	0.1	0.1	0.1
Body fat percentage	0.0	0.0	0.1	-0.2	-0.0	-0.3
Emphysema/chronic bronchitis	0.0	0.1	0.1	0.1	0.1	0.4
Mean time to correctly identify matches	0.0	0.1	0.2	0.1	-0.3	-0.4
Whole body fat mass	0.0	0.2	0.3	-0.4	-0.5	0.5
Leg fat mass (right)	0.0	0.0	0.0	-0.1	-0.2	0.2
Leg pain on walking	0.0	0.0	0.1	-0.1	-0.3	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	-0.1	-0.2	-0.1
Smoking status: Previous	0.0	0.0	0.0	0.1	-0.1	0.1
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	0.3	0.2	0.0
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	-0.1	-0.2	-0.1

Hub : Genes

TMEM171

Models

Trait associations