[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr1:18,932,744-20,503,710

Best TWAS P=3.71e-11 · Best GWAS P=9.1e-12 conditioned to NaN

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Thyroid	CAPZB	0.22	0.06	lasso	8	0.15	1.1e-11	-3.4	6.6	3.7e-11	0.28	0.93	0.07	TRUE
4	GTEx	Nerve Tibial	PQLC2	0.07	0.08	lasso	3	0.06	6.6e-05	6.2	-6.2	4.5e-10	-0.50	0.06	0.92	TRUE
7	The Cancer Genome Atlas	Thyroid Carcinoma	CAPZB	0.08	0.06	blup	160	0.07	1.2e-07	-3.1	6.2	6.5e-10	0.40	0.97	0.03	TRUE
1	GTEx	Adrenal Gland	PQLC2	0.19	0.03	lasso	3	0.02	5.4e-02	-2.3	-5.8	7.9e-09	-0.80	0.04	0.67	TRUE
6	METSIM	Adipose	PQLC2	0.07	0.02	lasso	6	0.05	9.2e-08	3.4	-5.3	1.4e-07	-0.40	0.61	0.33	TRUE
2	GTEx	Cells Transformed fibroblasts	AKR7A2	0.16	0.02	lasso	3	0.01	7.9e-02	5.2	-5.8	8.2e-09	-0.79	0.02	0.87	FALSE
3	GTEx	Lung	PQLC2	0.12	0.10	lasso	3	0.08	1.0e-06	5.3	-5.2	2.1e-07	-0.50	0.42	0.57	FALSE