[Hub]/) : Traits : Hypothyroidism (self reported) :

chr1:18,932,744-20,503,710

Best TWAS P=3.71e-11 · Best GWAS P=9.1e-12 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adrenal Gland PQLC2 0.19 0.03 lasso 3 0.02 5.4e-02 -2.3 -5.8 7.9e-09 -0.80 0.04 0.67 TRUE
2 GTEx Cells Transformed fibroblasts AKR7A2 0.16 0.02 lasso 3 0.01 7.9e-02 5.2 -5.8 8.2e-09 -0.79 0.02 0.87 FALSE
3 GTEx Lung PQLC2 0.12 0.10 lasso 3 0.08 1.0e-06 5.3 -5.2 2.1e-07 -0.50 0.42 0.57 FALSE
4 GTEx Nerve Tibial PQLC2 0.07 0.08 lasso 3 0.06 6.6e-05 6.2 -6.2 4.5e-10 -0.50 0.06 0.92 TRUE
5 GTEx Thyroid CAPZB 0.22 0.06 lasso 8 0.15 1.1e-11 -3.4 6.6 3.7e-11 0.28 0.93 0.07 TRUE
6 METSIM Adipose PQLC2 0.07 0.02 lasso 6 0.05 9.2e-08 3.4 -5.3 1.4e-07 -0.40 0.61 0.33 TRUE
7 The Cancer Genome Atlas Thyroid Carcinoma CAPZB 0.08 0.06 blup 160 0.07 1.2e-07 -3.1 6.2 6.5e-10 0.40 0.97 0.03 TRUE