Best TWAS P=3.71e-11 · Best GWAS P=9.1e-12 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | PQLC2 | 0.19 | 0.03 | lasso | 3 | 0.02 | 5.4e-02 | -2.3 | -5.8 | 7.9e-09 | -0.80 | 0.04 | 0.67 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | AKR7A2 | 0.16 | 0.02 | lasso | 3 | 0.01 | 7.9e-02 | 5.2 | -5.8 | 8.2e-09 | -0.79 | 0.02 | 0.87 | FALSE |
| 3 | GTEx | Lung | PQLC2 | 0.12 | 0.10 | lasso | 3 | 0.08 | 1.0e-06 | 5.3 | -5.2 | 2.1e-07 | -0.50 | 0.42 | 0.57 | FALSE |
| 4 | GTEx | Nerve Tibial | PQLC2 | 0.07 | 0.08 | lasso | 3 | 0.06 | 6.6e-05 | 6.2 | -6.2 | 4.5e-10 | -0.50 | 0.06 | 0.92 | TRUE |
| 5 | GTEx | Thyroid | CAPZB | 0.22 | 0.06 | lasso | 8 | 0.15 | 1.1e-11 | -3.4 | 6.6 | 3.7e-11 | 0.28 | 0.93 | 0.07 | TRUE |
| 6 | METSIM | Adipose | PQLC2 | 0.07 | 0.02 | lasso | 6 | 0.05 | 9.2e-08 | 3.4 | -5.3 | 1.4e-07 | -0.40 | 0.61 | 0.33 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | CAPZB | 0.08 | 0.06 | blup | 160 | 0.07 | 1.2e-07 | -3.1 | 6.2 | 6.5e-10 | 0.40 | 0.97 | 0.03 | TRUE |