Hub : Genes

PQLC2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.1876	0.0761	4.9e-03	0.035	NA	0.015	NA	0.022	2.1e-02	NA	9.3e-02	NA	5.4e-02
2	GTEx	Brain Cerebellum	0.2670	0.0830	9.1e-04	0.052	NA	0.044	NA	0.061	1.2e-02	NA	1.9e-02	NA	7.1e-03
3	GTEx	Breast Mammary Tissue	0.1880	0.0640	8.0e-04	0.036	NA	0.032	NA	0.040	5.8e-03	NA	8.5e-03	NA	4.0e-03
4	GTEx	Breast Mammary Tissue (Female)	0.0533	0.0916	3.2e-01	0.014	NA	0.015	NA	-0.009	1.2e-01	NA	1.2e-01	NA	7.5e-01
5	GTEx	Lung	0.1212	0.0357	1.7e-05	0.105	NA	0.071	NA	0.080	2.0e-08	NA	4.2e-06	NA	1.0e-06
6	GTEx	Nerve Tibial	0.0703	0.0288	4.7e-03	0.084	NA	0.031	NA	0.057	1.6e-06	NA	2.7e-03	NA	6.6e-05
7	GTEx	Testis	0.2280	0.0780	1.2e-04	0.143	NA	0.044	NA	0.087	6.7e-07	NA	4.9e-03	NA	1.0e-04
8	GTEx	Thyroid	0.1920	0.0490	3.1e-07	0.049	NA	0.080	NA	0.062	1.2e-04	NA	1.0e-06	NA	1.7e-05
9	METSIM	Adipose	0.0669	0.0250	3.7e-05	0.024	0.035	0.033	0.034	0.048	1.1e-04	5.1e-06	8.0e-06	6.1e-06	9.2e-08
10	ROSMAP	Brain Pre-frontal Cortex	0.1305	0.0338	4.4e-09	0.048	0.074	0.078	0.074	0.096	7.4e-07	7.6e-10	2.7e-10	9.6e-10	2.7e-12
11	TCGA	Breast Invasive Carcinoma	0.0189	0.0102	7.3e-03	0.004	0.006	0.006	NA	0.003	4.3e-02	1.8e-02	2.1e-02	NA	6.0e-02
12	TCGA	Esophageal Carcinoma	0.1550	0.0720	6.5e-03	0.053	-0.004	0.000	NA	0.123	9.0e-03	4.6e-01	3.3e-01	NA	9.9e-05
13	TCGA	Thyroid Carcinoma	0.0500	0.0300	9.9e-03	-0.002	0.011	0.021	NA	0.012	5.9e-01	2.6e-02	3.3e-03	NA	2.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.4	0.7	1.8	0.1	0.5	0.9	1.3	0.9	1.3	0.1	0.5	1.2	0.9	-0.7	-0.3	0.4
Bipolar Disorder or Schizophrenia	0.5	1.3	3.0	0.8	1.0	0.8	1.7	1.2	1.6	0.1	0.6	1.4	1.0	-1.7	-1.3	0.6
Depressed Affect (Nagel 2018)	0.5	1.0	3.0	0.0	0.9	-1.1	1.1	-1.7	-1.6	-0.2	-0.6	0.4	0.5	-1.0	-1.1	-1.1
Depression (Nagel 2018)	0.4	0.6	2.3	-0.1	-0.8	0.8	0.9	-0.4	-0.3	-0.9	-0.5	1.2	0.2	0.1	0.8	1.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	2.7	0.6	0.3	0.3	0.4	0.3	0.5	-0.1	1.1	1.6	0.9	-0.8	-0.2	0.4
Neuroticism (Nagel 2018)	0.6	1.5	4.5	1.0	1.9	-0.5	0.9	-0.9	-0.4	0.8	0.0	0.2	1.6	-2.1	-1.8	-1.3
Schizophrenia (2018)	0.4	0.8	2.4	1.0	0.8	0.3	1.1	0.8	0.9	0.1	0.4	1.1	0.6	-1.6	-1.4	0.5
Schizophrenia vs Biploar Disorder	0.2	0.3	1.0	-0.1	0.1	-1.0	0.1	-0.9	-0.7	-0.4	-0.2	-0.4	-0.1	-0.5	-0.1	-0.9
Worry (Nagel 2018)	1.2	2.5	8.0	1.7	2.6	-0.7	0.3	0.2	1.1	1.2	0.6	0.4	2.4	-2.8	-2.1	-1.0
Alzheimer’s Disease (in mother)	0.3	0.3	1.6	0.4	0.5	0.3	-1.2	0.2	0.7	-0.3	-0.3	0.3	0.5	-1.0	-0.6	0.2
Alzheimer’s Disease (in father)	1.1	1.2	2.3	1.0	1.5	1.5	-0.6	0.4	1.5	1.2	1.2	0.7	1.1	-1.5	-0.6	-0.8
Alzheimer’s Disease (including proxy)	1.1	1.6	4.2	0.7	1.8	1.5	-0.9	0.6	1.6	0.2	0.5	1.2	2.0	-2.1	-1.2	-0.2
Crohns Disease (2017)	0.3	0.7	2.3	0.1	0.0	1.5	1.5	1.0	0.9	0.0	0.4	1.1	1.0	-0.3	-0.1	0.3
Irritable Bowel Disease (IBD)	0.3	0.7	2.6	-0.4	-0.3	1.5	1.6	0.4	0.5	-0.3	-0.7	1.6	0.7	-0.0	0.0	0.3
Ulcerative Colitis (UC)	0.4	0.7	2.9	-0.3	-0.5	1.3	1.7	0.3	0.4	-0.1	-1.0	1.7	0.2	0.5	0.3	0.4
Major Depression (MDD)	0.8	0.9	4.5	0.3	-0.4	0.0	0.6	-2.1	-2.1	-0.3	-1.5	-0.4	-0.1	-0.2	-0.1	0.1
Reaction Time	0.7	1.3	3.8	1.7	-0.3	1.3	-1.0	0.9	0.3	2.0	0.5	-0.6	-0.8	1.4	0.9	1.6
Verbal and Numeric Reasoning (VNR)	0.1	0.2	1.3	0.3	0.4	0.4	-0.4	0.0	0.5	-0.1	1.1	0.4	0.4	-0.6	-0.3	0.3
Breast Cancer	0.3	0.6	2.0	0.4	0.6	-1.4	-0.8	-1.2	-1.0	0.3	-0.4	-1.1	-0.4	0.2	-0.7	0.5
Ovarian Cancer	0.8	1.0	3.8	0.4	1.0	-0.2	0.7	-0.5	0.1	-0.7	0.7	1.5	2.0	-1.9	-0.7	0.2
Prostate Cancer	0.2	0.2	0.8	0.1	0.9	0.6	0.3	-0.2	-0.0	0.5	0.3	-0.1	-0.1	0.7	-0.4	-0.6
Age at First Birth	0.7	1.1	3.1	1.8	0.5	1.0	0.0	0.7	1.3	1.5	1.0	-0.6	0.3	1.1	-0.1	1.7
Bipolar Disorder (2011)	0.8	0.8	2.4	0.1	1.3	-0.1	0.7	0.1	0.3	0.5	0.3	-0.9	1.1	-1.6	-1.4	-1.2
Body Mass Index (BMI) (2010)	0.4	0.5	2.2	-0.2	-1.0	-0.1	-0.3	0.1	-0.3	-1.0	-0.8	0.2	-0.3	0.7	0.9	1.5
Coronary Artery Disease (CAD)	0.8	0.9	4.5	-0.8	-0.4	-1.0	1.3	-1.8	-2.1	-0.8	-0.1	-0.1	0.4	0.4	0.0	0.2
Crohns Disease (2012)	0.4	0.7	1.7	0.8	0.4	0.5	0.5	1.3	1.2	0.1	1.1	0.4	1.1	-0.9	-0.6	0.7
Mean Putamen Volume	1.0	1.1	3.8	1.4	-0.4	1.2	0.8	1.2	1.1	0.9	0.7	1.9	-0.3	-0.2	0.7	1.5
Fasting Glucose	0.2	0.3	0.9	0.3	0.3	-0.9	0.5	-0.7	-0.5	0.1	0.1	0.1	0.9	0.2	-0.2	0.6
HbA1C	0.3	0.3	2.2	0.4	0.3	-0.6	-0.0	0.3	0.3	0.8	0.5	1.5	0.5	-0.1	-0.3	-0.1
HDL Cholesterol	1.0	1.7	4.8	-1.8	-0.5	-1.7	0.5	-1.7	-1.4	-2.2	-2.0	-0.3	0.0	-1.0	-0.2	-1.1
LDL Cholesterol	0.3	0.4	1.5	0.2	-0.2	-1.0	-1.2	-0.5	-0.9	0.3	-0.4	1.0	0.1	0.2	0.1	0.5
Lupus	0.6	1.0	2.8	-0.7	-1.2	1.2	1.4	1.7	1.6	-0.7	-0.4	0.5	-0.7	-0.1	0.6	0.6
Neuroticism (2016)	0.5	0.8	2.2	0.7	0.4	1.2	1.4	1.5	1.1	0.6	0.3	0.6	0.2	-0.7	-0.5	-0.9
Primary Biliary Cirrhosis	0.7	1.1	3.7	-1.6	-0.8	0.6	1.6	-0.5	-0.0	-1.9	-0.8	1.2	0.4	-1.1	0.6	0.5
Rheumatoid Arthritis	0.3	0.5	1.8	0.0	0.1	0.1	-0.3	-1.3	-0.7	-0.5	-1.3	0.4	-0.3	-0.5	-1.0	0.5
Schizophrenia (2014)	0.3	0.8	1.8	1.1	0.7	0.0	0.7	1.1	1.3	0.1	0.6	0.9	0.4	-1.3	-1.0	0.7
Triglycerides	0.5	0.8	3.1	1.5	0.6	-0.1	-0.8	0.7	0.8	1.3	1.8	0.1	0.6	0.3	-0.1	1.1
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.9	0.5	0.3	1.2	0.6	-0.4	0.1	0.4	-0.5	1.4	0.7	-0.8	-0.9	-0.2
Ulcerative Colitis	0.4	0.5	1.8	-0.4	0.3	0.5	0.9	-0.3	0.1	-0.3	-1.3	1.2	-0.1	-0.5	-1.2	-0.4
Blood Eosinophil Count	0.1	0.9	3.7	-1.9	-0.8	0.2	0.9	0.5	0.1	-1.9	-0.6	0.7	0.8	0.1	0.9	-0.1
Blood Platelet Count	0.6	6.7	16.8	-2.2	-0.7	2.3	4.1	1.6	2.0	-3.6	-0.9	4.1	3.8	-2.9	0.1	0.6
Blood Red Count	0.1	1.0	7.4	-0.0	0.1	0.4	-0.6	-0.3	0.5	-0.1	-0.4	2.7	1.6	-0.0	-0.1	1.3
Blood White Count	0.4	3.2	15.7	1.8	-1.3	1.4	1.3	1.3	0.7	1.6	1.6	1.8	0.8	2.3	1.1	4.0
Heel T-Score	0.6	4.5	26.0	1.6	1.3	-1.3	-0.7	0.9	0.5	2.9	5.1	-2.2	-2.8	0.1	0.2	-2.1
BMI	0.5	3.2	11.0	-1.1	-0.8	-2.7	-1.0	-3.3	-3.1	-0.8	-2.1	-1.8	-0.9	1.1	0.3	0.7
Height	1.6	31.3	102.0	4.9	4.8	6.7	-0.1	8.2	10.1	3.9	5.3	5.2	7.7	-3.5	-1.5	0.7
Waist Hip Ratio (WHR)	0.2	0.7	3.0	-0.7	-0.5	0.8	0.1	-1.2	-0.7	-0.9	-1.7	-1.3	-0.6	-0.1	-0.2	0.3
Systolic Blood Pressure	0.4	1.9	6.4	-0.8	0.3	0.7	1.1	1.1	1.5	-0.4	1.9	2.5	2.4	-1.7	0.4	-0.5
Smoking Status	0.1	0.4	0.9	0.8	0.1	0.3	0.7	1.0	0.6	-0.2	-0.2	0.1	0.4	-0.9	-0.1	1.0
Allergy or Eczema	0.9	2.3	9.5	-2.5	0.3	-0.9	0.9	-1.0	-0.1	-3.1	-2.0	0.9	1.9	-1.2	-0.0	-1.0
Cardiovascular Disease	0.2	0.5	3.5	0.4	-0.6	0.2	-0.1	0.9	0.1	0.4	1.9	-0.5	-0.5	0.4	1.0	0.5
Hypothyroidism (self reported)	7.1	16.3	38.9	-5.8	-1.9	-3.6	-2.1	-5.2	-6.2	-4.5	-4.6	-5.3	-2.8	2.3	0.8	-2.8
Respiratory disease	0.7	1.6	4.3	1.6	0.2	0.3	-1.3	1.4	1.8	2.1	2.0	-0.7	0.0	1.3	0.7	0.5
Type 2 Diabetes (T2D) (2018)	1.4	2.7	7.1	2.2	0.9	2.7	0.2	2.4	2.3	2.3	1.4	-0.5	0.7	0.9	-0.1	1.5
Lung FEV1/FVC ratio	2.4	12.3	33.3	-4.4	0.5	-2.6	3.6	-4.2	-3.0	-5.8	-3.9	4.1	3.1	-4.0	-1.7	-0.8
Lung FVC	1.6	7.9	20.3	-2.9	-0.9	-3.6	-2.6	-4.4	-4.5	-4.0	-3.5	-1.1	-0.4	-1.8	-0.3	-1.5
Neuroticism	0.9	2.1	6.8	0.7	2.2	-0.4	1.6	-0.6	0.2	0.6	0.2	0.4	1.6	-2.6	-2.3	-1.8
Chronotype (morning person)	1.2	2.8	8.5	-2.1	0.4	-2.0	-2.9	-2.3	-1.4	-1.8	-2.1	-0.9	1.6	-0.7	-0.3	-0.2
Hair Pigment	0.3	7.7	16.6	3.9	2.8	2.3	3.7	2.7	3.2	2.5	4.1	1.5	1.2	-2.9	-2.1	0.5
Tanning	0.2	2.7	6.2	-0.7	-2.3	-2.1	-1.6	-1.1	-2.5	-0.6	-1.1	0.2	-0.7	2.4	1.9	1.9
Hand grip strength (left)	1.1	2.8	6.5	1.7	2.4	0.7	-0.3	1.4	2.5	2.0	1.6	-2.1	2.1	-0.8	-1.4	-0.6
Number of treatments/medications taken	0.7	1.2	4.0	1.7	-0.6	0.3	-0.3	1.3	0.3	1.8	0.8	-0.7	-0.6	1.1	0.7	2.0
Average weekly spirits intake	0.7	0.9	2.7	-1.1	-0.5	1.0	0.8	0.9	0.5	-1.6	-1.4	1.4	0.4	-0.6	0.3	-0.2
Sensitivity / hurt feelings	0.4	0.8	3.3	0.8	1.1	-0.1	-0.2	-0.4	-0.3	1.8	-0.1	-1.6	0.4	0.2	-1.1	-0.6
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.4	-0.6	0.1	-0.1	0.3	-0.6	-0.1	-1.2	-0.8	0.6	1.0	-0.6	-0.1	0.6
Hearing difficulty/problems: Yes	0.3	0.5	1.5	-0.7	0.0	0.4	-0.8	-1.1	-1.2	-0.4	0.2	-0.6	-1.0	-0.6	-0.3	-1.0
Relative age of first facial hair	0.2	0.5	2.1	-0.9	-0.7	0.9	-0.1	-0.5	-0.7	-1.5	-0.9	-0.3	0.4	0.3	0.7	0.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.9	0.3	-1.2	0.7	-0.3	0.7	-0.3	-0.5	0.7	0.4	-1.7	1.0	0.9	1.1
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.9	-0.7	1.4	1.0	-0.7	0.0	0.5	-0.4	-1.0	0.5	1.5	-1.2	-1.5	-1.7
Ever had hysterectomy (womb removed)	0.6	0.7	2.6	0.1	-0.0	1.6	-1.0	0.6	1.5	0.4	-0.2	1.0	0.5	1.0	0.5	0.7
Systolic blood pressure, automated reading	0.4	1.1	3.5	0.7	0.9	0.1	-0.9	0.1	0.8	1.1	1.2	1.9	1.7	-1.4	-0.6	-0.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.2	-0.7	0.0	0.2	-0.1	-0.1	-0.4	0.2	-0.6	-1.5	0.7	1.3	1.0	0.0
Angina	0.7	0.9	1.7	0.7	1.2	1.3	1.1	0.7	1.1	0.6	0.9	0.9	1.1	-0.9	-1.3	-0.2
Medication for hormone replacement therapy	0.3	0.3	2.3	0.2	0.6	0.0	-0.3	0.2	0.4	-0.0	-0.2	1.5	0.4	-0.5	-0.8	0.1
Vitamin and mineral supplements	0.4	0.6	2.7	-0.1	-1.0	-0.5	0.1	-0.3	-1.1	0.2	0.8	-1.6	-0.3	1.0	0.9	0.0
Supplements: Zinc	1.7	1.8	4.7	-1.9	1.3	-0.7	0.1	-1.6	-0.1	-2.2	-1.7	0.6	1.5	-1.6	-1.0	-1.3
Medication: Co-codamol	0.6	0.7	1.3	0.7	-1.0	-0.6	1.0	-0.9	-0.7	1.1	-0.1	-0.5	-0.9	0.7	0.7	1.1
Medication: Metformin	2.7	3.8	10.4	1.9	1.6	2.6	-0.4	3.0	3.2	2.0	1.4	1.7	2.5	0.3	-0.0	1.4
Diabetes (father)	1.0	1.3	3.4	-0.3	-1.6	1.8	0.5	1.8	0.9	-0.2	0.2	0.3	-1.0	1.1	1.6	1.1
Diabetes (mother)	0.4	0.5	1.8	0.2	-0.2	-1.2	-0.4	0.7	0.1	0.8	0.9	-0.5	-0.7	1.3	-0.0	0.0
Severe depression (siblings)	1.1	1.2	3.9	-0.5	1.2	-0.8	0.0	-2.0	-1.0	-0.2	-1.5	-1.3	0.5	-0.3	-1.4	-1.6
Pack years adult smoking proportion	1.6	2.4	7.9	1.0	-2.1	0.7	0.9	1.1	0.1	0.6	1.6	0.2	-1.6	2.3	2.1	2.8
Impedance of leg (right)	0.1	0.7	2.2	-0.6	-0.7	1.5	1.0	1.2	0.8	-0.7	0.2	0.7	-0.4	-0.7	0.8	-0.8
Leg fat-free mass (left)	0.3	1.5	8.2	1.0	1.8	0.8	-1.1	0.5	1.9	0.6	0.7	-0.1	2.9	-0.8	-0.5	0.6
Trunk fat percentage	0.1	0.2	0.8	0.6	-0.2	-0.0	-0.1	-0.7	-0.7	0.4	0.0	-0.9	-0.4	-0.2	0.2	0.4
Hand grip strength (right)	1.0	2.6	8.2	0.8	2.2	1.5	0.0	1.8	2.9	1.2	1.3	-1.2	2.3	-1.4	-1.0	-1.4
Townsend deprivation index at recruitment	0.6	0.9	3.2	-0.7	0.9	-0.2	-0.2	-1.1	-0.8	-0.5	-0.8	1.0	1.8	-1.3	-0.9	-0.5
Current tobacco smoking	0.7	1.1	5.3	-0.4	1.3	-0.3	0.5	-0.1	0.4	-1.2	-0.9	1.3	2.3	-1.4	-1.1	-0.3
Average weekly fortified wine intake	0.1	0.1	0.4	0.5	-0.2	-0.0	0.6	-0.6	-0.4	0.5	0.3	-0.1	-0.1	-0.1	-0.2	0.1
Maternal smoking around birth	0.6	0.9	3.0	0.1	-0.9	-1.1	-1.7	-0.0	-0.5	0.8	0.8	-1.1	-1.5	1.1	0.8	0.1
Fed-up feelings	0.2	0.4	2.4	0.4	0.4	-0.7	1.6	-0.6	-0.8	0.7	0.4	0.1	-0.1	-0.3	-0.4	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	2.6	0.6	-0.3	0.3	0.2	-0.4	-0.1	-0.4	-0.1	0.5	0.0	-0.5	0.1	1.6
Relative age voice broke	0.9	1.4	8.3	-1.0	-0.4	-0.5	-2.9	-1.0	-1.2	-0.7	-2.0	-0.8	-0.0	0.8	0.2	-0.4
Taking other prescription medications	0.5	0.8	2.6	0.6	-0.9	-0.2	0.3	0.3	-0.4	1.1	0.0	-1.5	-0.9	1.6	0.8	1.1
Age when periods started (menarche)	1.0	2.4	5.7	-1.9	-0.6	-1.7	-0.8	-1.1	-1.6	-2.3	-2.1	-2.4	-1.3	-0.7	-0.0	-1.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	2.1	-0.3	0.9	1.4	-0.6	-0.4	0.6	0.5	-0.5	-0.1	0.8	0.2	-1.0	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	5.8	-0.6	-0.1	0.1	-0.2	0.0	-0.2	0.6	1.6	-1.2	-2.4	1.0	0.7	-1.3
Tinnitus: Yes, but not now, but have in the past	2.2	2.4	8.7	3.0	-0.3	0.5	0.2	2.0	1.9	2.6	1.2	-0.2	-0.9	0.9	0.5	2.1
Qualifications: CSEs or equivalent	0.5	0.6	2.6	-1.0	-0.5	-1.6	0.5	-1.0	-0.7	-0.6	-0.6	-0.4	-0.6	-0.4	0.4	-0.9
Serious illness, injury or assault to yourself	0.7	0.9	2.9	-0.7	0.6	1.2	0.8	-1.3	-1.3	-0.7	-1.7	0.9	0.7	0.4	-0.2	-0.3
High blood pressure	0.2	0.5	1.3	0.8	0.3	0.7	0.1	0.8	1.0	0.7	0.6	0.9	1.1	-0.4	0.2	0.2
Hayfever, allergic rhinitis or eczema	0.6	1.4	7.2	-1.6	0.0	-1.3	0.1	-1.1	-0.6	-2.7	-1.7	0.6	0.9	-1.2	-0.2	-0.3
Multivitamins +/- minerals	0.5	0.7	3.6	0.7	0.8	0.3	0.2	0.1	0.8	-0.4	-0.5	1.6	0.1	-1.9	-0.7	0.2
Stomach or abdominal pain in last month	1.7	2.1	4.9	-2.2	1.0	-0.5	-2.0	-1.6	-0.8	-2.0	-1.7	-0.4	1.7	-1.0	-0.8	-1.5
Supplements: Glucosamine	0.5	0.6	1.8	-0.2	-0.1	-1.2	-0.9	-0.7	-0.7	-0.4	-1.3	-1.3	-0.4	0.6	0.3	0.3
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.7	-0.1	-1.4	0.7	0.6	1.2	0.2	-0.9	0.1	1.0	-0.7	-0.1	1.6	0.3
Medication: Atenolol	0.7	0.9	2.7	1.6	1.1	0.7	-0.7	0.5	0.4	1.6	1.5	-0.3	0.8	-0.2	-0.6	0.1
Medication: Levothyroxine sodium	4.9	8.3	23.4	-3.9	-1.0	-2.9	-2.1	-3.9	-4.8	-3.1	-2.7	-3.5	-1.8	1.6	0.6	-2.1
Sitting height	2.7	19.1	57.3	3.9	4.7	5.0	0.1	5.3	7.6	2.5	4.6	2.4	7.4	-3.0	-1.6	0.3
Chronic bronchitis/emphysema (father)	0.7	0.8	6.2	0.2	0.1	-1.2	-2.5	-0.8	-0.9	0.2	-0.5	0.3	-0.7	0.1	-0.6	0.4
High blood pressure (mother)	2.2	3.1	9.5	2.2	0.2	1.4	0.7	2.8	2.7	3.1	2.3	-0.7	-1.3	0.3	0.6	-0.2
Body mass index (BMI)	0.3	1.4	6.6	-0.3	-0.2	-1.5	-1.0	-2.6	-2.3	-0.4	-1.1	-1.1	-0.3	0.3	0.0	0.7
Impedance of leg (left)	0.1	0.6	2.5	-0.4	-0.5	1.6	0.7	1.4	0.9	-0.4	0.3	0.7	-0.3	-0.6	0.5	-0.8
Leg predicted mass (left)	0.3	1.5	8.1	0.9	1.7	0.8	-1.0	0.5	1.8	0.5	0.6	-0.1	2.8	-0.8	-0.4	0.6
Trunk fat mass	0.1	0.3	1.0	1.0	0.6	0.5	-0.5	-0.1	0.4	0.6	0.4	-0.5	0.9	-0.5	0.0	0.7
Waist circumference	0.3	1.0	4.4	-0.2	-0.6	-0.2	-2.1	-1.3	-1.2	-0.6	-1.7	-0.7	0.1	0.3	0.5	1.3
Number of incorrect matches in round	0.6	1.1	4.9	2.1	0.9	0.7	-0.4	0.5	1.1	2.2	0.3	-0.1	0.7	-0.7	-0.6	0.3
Past tobacco smoking	1.5	2.7	7.6	-2.8	1.1	-0.5	-0.8	-2.4	-1.2	-2.2	-2.0	-0.1	1.7	-0.7	-1.2	-2.2
Alcohol usually taken with meals	0.7	1.1	3.3	0.8	-0.2	1.2	0.8	1.5	1.8	1.4	0.9	-0.1	-0.2	1.2	0.8	0.9
Nervous feelings	1.2	2.2	5.3	1.7	2.3	-0.8	-0.3	-0.2	0.3	2.2	0.4	-0.2	1.9	-2.0	-2.3	-1.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.7	-0.3	-0.2	-1.0	-0.7	-0.9	-0.6	-0.8	-0.5	0.2	1.0	-0.2	0.1	1.3
Hearing difficulty/problems with background noise	0.5	0.7	2.3	-0.9	-0.5	0.2	-1.3	-1.1	-1.4	-1.5	-0.2	0.7	-0.3	-0.4	0.3	0.6
Hair/balding pattern: Pattern 2	0.4	0.5	1.3	-0.2	-1.0	-0.1	1.1	-0.4	-1.1	-0.3	0.4	-0.7	-0.4	0.8	0.7	0.8
Had menopause	1.0	1.2	4.2	1.1	-1.2	2.0	0.2	1.0	0.9	0.8	-0.4	1.2	-0.2	1.3	1.2	1.2
Had other major operations	0.8	1.0	3.2	-1.7	-0.1	0.3	-0.1	-1.6	-1.0	-1.2	-1.8	0.7	0.3	0.0	0.0	-1.0
Forced vital capacity (FVC)	0.5	2.1	8.2	-1.4	1.1	-0.6	-1.0	-1.1	-0.3	-2.9	-1.0	-0.4	1.9	-2.5	-0.9	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	9.9	-0.2	-0.6	-1.0	-0.2	-0.2	-0.8	1.3	1.7	-2.1	-3.1	1.2	1.4	-1.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.0	-0.5	-0.7	-0.8	-0.3	-1.0	-1.0	-0.2	-0.9	0.1	-0.2	0.8	0.1	0.6
Qualifications: None of the above	0.8	1.8	5.0	1.0	-1.2	-1.1	-1.8	-0.1	-1.1	1.6	0.3	-1.4	-2.2	1.9	1.3	0.1
Financial difficulties in last 2 years	1.1	1.5	3.6	-1.5	-1.1	-1.5	0.3	-1.6	-1.9	-1.7	-1.7	0.2	-0.8	0.2	1.2	0.0
Mouth/teeth dental problems	1.0	1.6	5.7	0.9	1.5	1.2	2.4	0.8	1.5	1.0	1.3	-0.6	1.1	-0.9	-1.3	-0.7
Heart attack	0.9	1.1	4.8	2.2	-0.4	0.8	-0.3	-0.5	-0.8	1.3	-0.1	-0.7	-1.2	1.0	0.3	1.8
Allergy	0.1	0.1	0.5	-0.1	0.3	0.3	0.2	-0.4	-0.6	0.1	-0.5	0.1	0.1	-0.1	-0.7	-0.6
Pain all over the body in last month	0.4	0.4	1.0	0.9	0.2	-1.0	-1.0	-0.7	-1.0	0.5	0.1	0.2	0.3	-0.4	-0.5	0.2
Diabetes (self-reported)	0.9	1.5	4.8	1.6	0.6	2.2	-0.1	1.5	1.1	1.4	0.7	-0.0	0.7	1.1	0.2	1.9
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	3.2	-0.4	1.2	-1.1	0.2	-1.8	-1.1	-0.2	-0.8	-1.0	0.6	-0.9	-0.9	-1.7
Medication: Ramipril	0.7	0.9	1.8	1.3	-0.3	0.7	0.3	1.1	0.4	1.3	1.0	-1.0	-0.5	1.3	1.2	0.9
Medication: Simvastatin	0.9	1.3	3.4	1.8	0.2	0.0	-1.8	1.2	0.5	1.6	1.4	-1.4	-0.4	0.8	0.3	1.1
Fluid intelligence score	0.3	0.6	1.7	0.5	1.1	0.6	0.6	0.8	1.2	0.6	1.3	-0.7	0.6	-0.7	-0.8	-0.1
Illnesses of siblings	0.6	0.9	4.0	-0.9	0.3	-0.3	-0.2	-1.6	-1.0	-2.0	-1.2	-0.1	0.6	-0.5	-0.6	0.2
Neuroticism score	0.5	1.1	3.0	0.7	1.6	-1.1	1.0	-0.6	-0.3	0.7	-0.0	-0.8	0.6	-1.6	-1.7	-1.4
Weight	0.2	1.0	5.7	1.0	1.3	0.6	-1.2	-0.0	1.0	0.3	0.2	-0.0	2.4	-0.8	-0.3	1.0
Impedance of arm (right)	0.1	0.4	2.4	-0.0	-0.5	0.5	0.1	0.6	-0.2	0.1	0.4	-1.0	-1.5	-0.3	0.3	-1.0
Arm fat percentage (right)	0.3	1.1	4.6	0.1	-0.5	-1.0	-0.6	-2.1	-2.2	0.0	-0.5	-1.3	-1.1	0.4	0.3	0.9
Trunk fat-free mass	0.7	3.9	18.6	1.6	2.3	1.8	-1.5	1.7	3.2	1.0	1.1	0.6	4.3	-1.1	-0.6	1.1
Hip circumference	0.1	0.4	2.5	0.1	-0.4	-0.6	-1.6	-0.5	-0.5	-0.3	-0.5	-0.2	0.6	0.4	0.6	1.0
Time employed in main current job	0.7	0.8	2.0	0.7	-0.5	1.2	1.1	1.1	0.7	1.4	0.2	-0.1	-0.5	1.3	1.1	0.4
Alcohol intake versus 10 years previously	0.9	1.3	2.5	-1.5	1.0	-0.9	-0.6	-1.4	-1.4	-1.4	-1.2	-0.1	0.2	-0.8	-1.6	-1.4
Father’s age at death	0.3	0.4	2.8	-0.0	-0.2	-0.8	-0.7	0.0	-0.1	-0.6	-1.7	0.3	0.4	-0.4	-0.1	0.0
Worrier / anxious feelings	0.6	1.2	2.7	-1.1	1.4	-1.1	0.5	-0.6	0.2	-0.7	-1.3	-1.1	1.5	-1.1	-1.0	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.2	-0.3	-0.2	0.3	0.1	-1.1	-0.9	0.1	-0.6	-0.7	-0.4	0.2	0.4	-0.5
Falls in the last year	0.8	1.1	4.1	-1.4	0.0	-0.4	-1.6	-0.0	0.2	-2.0	-0.7	1.4	0.8	-1.3	-0.4	-0.5
Hair/balding pattern: Pattern 3	1.0	1.4	5.1	0.6	-1.4	1.3	0.3	2.2	1.6	-0.5	0.3	1.6	-0.6	-0.2	1.4	1.4
Number of live births	1.3	1.8	6.3	-1.9	-0.5	-1.5	-0.6	-1.5	-1.3	-2.5	-2.0	0.6	0.5	-0.9	0.6	-0.8
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	17.0	-2.7	0.7	-1.5	-0.2	-2.3	-1.4	-4.1	-1.9	0.3	2.1	-2.7	-0.8	-1.2
Pulse rate	0.6	0.9	3.9	2.0	0.3	0.6	-1.4	0.7	0.7	1.4	0.5	-0.5	-0.3	-0.1	-0.7	1.3
Happiness	0.7	0.9	2.1	-1.2	-0.1	-1.0	-1.4	-1.4	-1.2	-0.6	-1.0	-1.4	-0.1	0.4	0.2	-0.3
Noisy workplace	0.6	0.8	2.5	-0.7	-0.6	0.2	-1.6	-0.9	-1.3	0.1	-0.2	-1.2	-1.4	0.3	0.3	-0.7
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.9	-0.0	1.1	1.7	1.0	0.5	1.2	-0.6	-0.6	2.0	1.1	-0.9	-1.1	0.4
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	8.7	-0.3	0.8	1.4	3.0	1.2	1.8	-0.5	-0.1	1.3	1.5	-1.2	-0.9	-0.4
Mouth/teeth dental problems: Dentures	0.5	0.8	2.9	0.2	-1.7	-0.3	-0.3	0.6	-0.5	-0.1	0.6	0.4	-1.0	0.9	1.6	1.4
Asthma	0.7	1.3	3.1	1.3	-0.1	0.5	-0.4	1.7	1.8	1.5	1.7	-1.0	-0.7	1.2	0.4	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.5	-1.0	0.5	-1.2	-0.7	0.1	0.6	-1.2	-0.9	0.8	1.1	-1.0	-0.5	-0.4
Medication: Cholesterol lowering	1.6	2.4	7.6	2.4	0.5	1.1	-0.4	1.8	1.4	2.4	2.8	-1.7	0.2	0.9	0.5	1.3
Depression (self-reported)	0.7	0.9	3.1	0.5	1.3	0.8	1.8	-0.5	0.4	0.1	-0.8	0.8	1.1	-1.1	-1.2	-0.2
Medication: Lansoprazole	1.0	1.2	4.7	-0.4	0.1	-1.3	-0.3	-2.1	-2.2	0.5	-1.4	-0.9	-0.2	0.6	-0.2	-0.9
Prospective memory result	0.7	0.8	5.2	0.9	0.3	0.3	0.6	0.5	0.5	0.6	1.1	2.3	1.0	-1.0	0.3	0.7
Lung cancer (father)	0.9	1.0	2.8	1.2	1.7	-0.5	-1.3	-0.1	0.3	0.8	1.5	0.8	0.8	-0.6	-1.3	-0.6
Illnesses of mother	3.0	3.7	17.6	-2.9	0.1	0.2	-0.2	-2.7	-2.0	-4.2	-2.5	0.2	1.2	-1.4	-0.6	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	13.5	-2.7	0.6	-1.5	-0.1	-2.2	-1.4	-3.7	-2.2	-0.6	1.7	-2.7	-0.8	-1.7
Pulse wave Arterial Stiffness index	0.6	0.7	3.6	1.1	0.1	0.2	0.3	0.1	0.5	0.2	0.1	1.9	1.1	-0.5	-0.2	1.6
Impedance of arm (left)	0.2	1.0	3.4	0.7	-0.6	1.3	0.6	1.7	0.7	0.8	1.2	-0.9	-1.9	-0.2	0.4	-0.9
Arm fat mass (right)	0.1	0.4	1.6	0.6	0.3	-0.5	-0.5	-1.3	-0.8	0.4	-0.1	-0.7	0.3	-0.1	0.0	0.9
Trunk predicted mass	0.7	3.9	18.3	1.6	2.3	1.9	-1.5	1.8	3.3	1.0	1.1	0.5	4.3	-1.0	-0.6	1.1
Standing height	1.4	13.9	49.6	2.8	3.5	4.8	-0.3	5.3	7.0	1.8	2.9	2.1	6.1	-2.5	-0.9	0.2
Length of working week for main job	0.2	0.2	1.2	-0.7	0.0	-0.3	-0.5	-0.5	-0.3	-0.6	-1.1	-0.1	-0.0	-0.2	-0.3	-0.4
Exposure to tobacco smoke at home	1.1	1.3	5.8	-0.8	-1.1	-2.4	0.3	-1.8	-1.8	-0.3	-0.3	1.1	-0.4	0.3	0.8	0.5
Breastfed as a baby	0.5	0.6	2.4	-0.2	0.3	1.5	-0.4	-0.3	-0.3	-1.5	-0.4	0.6	0.5	-0.8	-1.0	-0.1
Tense / ‘highly strung’	1.0	1.7	7.3	1.0	1.9	-0.4	0.2	0.1	0.6	-0.2	-0.1	0.8	1.8	-2.7	-2.2	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.4	1.1	-0.2	-1.6	0.9	-0.7	-1.2	0.9	0.5	-0.2	-0.4	0.3	0.1	0.5
Hair/balding pattern: Pattern 4	0.8	2.0	9.5	1.3	2.0	1.3	0.3	1.7	3.1	1.3	1.1	1.0	0.9	-0.9	-1.1	-0.5
Birth weight of first child	0.7	1.4	4.7	-0.3	1.7	0.9	-0.0	-0.0	1.1	-0.6	0.1	-0.2	1.1	-2.2	-1.7	-1.9
Peak expiratory flow (PEF)	2.7	6.3	32.0	-4.0	-0.3	-2.2	0.8	-2.3	-1.8	-5.7	-2.1	1.7	2.1	-2.6	-0.3	-0.8
Pulse wave reflection index	0.3	0.3	1.2	-0.7	0.8	-0.2	0.7	0.0	0.5	-0.5	-0.1	0.2	0.6	-0.4	-0.5	-1.1
Ever highly irritable/argumentative for 2 days	0.9	1.1	8.4	0.0	-0.3	-0.8	2.9	-1.2	-1.0	-0.4	-0.6	0.5	0.0	0.6	-0.4	1.3
Loud music exposure frequency	0.8	0.9	2.7	1.3	0.5	0.9	-0.0	1.0	1.5	1.6	1.4	-0.3	0.7	-0.3	-0.1	0.8
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	9.5	-0.4	1.2	1.0	0.7	0.5	1.8	-1.2	0.1	3.1	2.0	-1.2	-1.2	0.4
Mouth/teeth dental problems: Bleeding gums	1.0	1.2	3.4	-0.9	-1.1	-0.6	-1.8	-1.0	-1.8	-0.8	-1.4	-0.4	-1.2	0.4	1.2	0.0
Blood clot in the leg (DVT)	0.9	1.1	3.2	-0.3	-1.4	-1.0	-1.8	0.0	-0.6	0.4	0.3	-1.2	-1.1	1.4	1.6	0.8
Medication: Paracetamol	0.4	0.6	4.8	1.1	-0.5	-0.3	1.0	0.7	0.1	0.0	0.5	0.2	0.2	-0.4	0.4	2.2
Headache pain in last month	0.3	0.5	1.6	0.3	0.8	0.1	0.8	-0.2	-0.3	0.3	1.2	-0.5	-0.2	-1.1	-0.8	-1.0
Medication for cholesterol, blood pressure or diabetes	1.7	2.9	9.9	-2.5	-0.0	-1.1	0.0	-2.3	-1.7	-2.6	-3.1	1.1	-0.2	-1.0	-1.0	-1.5
Glaucoma (self-reported)	0.9	1.1	3.9	1.2	0.4	1.0	0.7	2.0	1.6	1.2	0.6	0.7	0.4	0.2	-0.4	1.3
Gout (self-reported)	0.3	0.5	2.2	-0.3	0.0	-0.8	-1.5	-0.7	-0.4	-0.9	0.0	-0.3	0.7	0.4	-0.0	0.9
Hypothyroidism/myxoedema (self-reported)	6.4	12.5	31.5	-5.0	-1.2	-3.2	-1.8	-4.8	-5.6	-3.9	-4.0	-4.5	-2.0	1.8	0.5	-2.8
Medication: Amlodipine	0.2	0.3	1.9	0.5	0.1	-0.2	-0.4	-0.2	-0.6	0.9	0.2	-1.4	0.2	0.7	-0.1	0.4
Medication: Ventolin 100micrograms inhaler	1.5	1.9	7.6	0.8	-0.8	1.3	1.2	2.8	2.4	0.7	1.3	0.5	0.3	-0.2	1.4	1.6
Birth weight	0.3	0.7	2.8	0.1	0.5	1.1	-1.1	-0.2	0.7	-1.3	-0.7	-1.7	0.6	-0.5	-0.2	0.6
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.6	0.4	0.6	-1.4	-1.6	0.4	0.3	1.3	-0.4	-0.0	-0.2	-0.9	-0.5	-1.1
High blood pressure (siblings)	0.4	0.5	1.4	-0.5	-0.8	-0.8	-0.2	-0.1	-0.2	0.8	0.2	-1.0	-0.8	1.1	1.2	-0.1
Forced vital capacity (FVC), Best measure	0.6	2.1	6.8	-1.5	1.0	-0.7	-0.6	-1.2	-0.5	-2.6	-1.4	-0.9	1.8	-2.5	-0.9	-1.5
Body fat percentage	0.1	0.5	1.7	0.3	-0.5	-0.5	-0.5	-1.3	-1.3	0.1	-0.3	-0.9	-0.7	0.1	0.5	0.7
Leg fat percentage (right)	0.4	1.5	5.7	-0.6	-0.9	-1.4	-1.2	-2.2	-2.4	-1.0	-1.1	-0.5	-0.9	0.1	0.8	0.6
Arm fat-free mass (right)	0.6	3.0	14.2	1.3	2.0	1.7	-1.1	1.5	3.0	0.8	0.9	0.5	3.8	-0.9	-0.6	0.9
Exposure to tobacco smoke outside home	0.4	0.5	2.0	-0.3	0.1	-1.4	-0.5	-0.5	-0.7	-0.5	-0.7	0.6	0.9	-0.9	-0.4	0.5
Comparative body size at age 10	0.7	1.8	5.4	1.6	-1.1	-0.2	1.2	1.5	0.4	2.3	1.1	0.5	-1.3	2.1	1.0	1.4
Number of full brothers	0.8	1.0	3.6	-0.8	0.2	-1.0	-0.6	-0.7	-0.6	-1.7	-0.5	1.5	0.5	-1.9	-1.0	0.1
Worry too long after embarrassment	0.5	0.8	2.4	-1.5	-0.2	-1.2	-1.2	0.2	0.4	-0.7	-0.8	-1.0	-0.3	-0.6	0.3	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.8	0.5	-0.1	0.2	0.6	-0.2	0.1	0.9	0.2	0.8	-0.3	-0.1	0.4	0.0
Wheeze or whistling in the chest in last year	0.8	1.4	4.5	1.6	1.3	0.5	-0.1	0.8	0.7	2.1	1.8	-1.1	1.3	-0.9	-0.9	-0.7
Number of children fathered	0.4	0.5	3.2	0.2	0.0	0.4	0.9	1.0	0.9	0.2	1.8	-0.1	0.1	-0.8	0.1	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.2	-0.2	0.5	-1.1	1.1	-0.4	-0.1	0.3	0.0	-1.5	-0.3	-0.4	-0.8	-1.0
Age at first live birth	0.5	0.9	2.9	1.4	-0.0	-1.2	-0.4	0.4	0.2	1.7	0.2	-1.3	-0.8	1.4	0.4	0.4
Pulse wave peak to peak time	0.4	0.5	2.5	-0.8	0.1	0.3	-0.2	0.4	0.1	0.0	0.5	-1.6	-0.7	0.3	0.2	-1.5
Health satisfaction	0.3	0.4	1.8	1.2	-0.1	-0.1	-0.2	0.7	0.7	0.8	0.6	0.2	-0.1	0.0	0.4	1.4
Shortness of breath walking on level ground	0.3	0.4	1.0	0.6	0.6	-0.3	-0.9	-1.0	-0.8	0.3	0.2	-0.0	0.5	0.1	-0.7	0.6
Qualifications: College or University degree	0.3	0.8	2.7	-0.7	0.8	-1.3	-0.3	-1.6	-0.9	-1.1	-0.6	-0.5	1.0	-0.6	-0.9	-0.2
Eye problems/disorders: None of the above	3.4	3.9	10.1	-2.1	0.7	-2.7	-0.6	-3.2	-2.3	-2.2	-2.1	-1.9	0.1	-1.5	-1.1	-2.6
Mouth/teeth dental problems: Loose teeth	1.9	2.2	6.2	-1.5	-2.5	-0.9	-0.5	-0.8	-1.7	-1.5	-1.8	-0.1	-1.9	1.7	1.5	1.1
Emphysema/chronic bronchitis	1.9	2.1	7.6	2.6	-0.0	1.2	0.4	1.4	1.4	2.8	1.7	-0.7	-0.4	1.0	0.8	1.6
Medication for pain relief, constipation, heartburn	0.5	0.8	4.0	-0.8	0.5	0.6	-0.6	-1.2	-0.3	-0.3	-1.1	1.4	0.3	-0.5	-0.4	-2.0
Neck or shoulder pain in last month	0.4	0.6	1.9	-1.0	-0.6	0.5	0.6	0.2	-0.2	-0.6	-0.3	1.4	1.0	-0.3	1.2	0.7
Medication: Blood pressure	1.2	2.1	7.7	2.2	-0.1	0.8	0.5	1.9	1.3	2.3	2.8	-0.8	0.1	0.8	0.9	1.1
Angina (self-reported)	0.5	0.7	1.4	0.8	1.0	1.0	1.0	0.5	0.7	0.7	0.7	0.7	0.9	-0.8	-1.2	0.1
Migraine (self-reported)	1.4	1.7	3.8	-1.2	1.1	-1.7	-0.2	-1.9	-1.6	-1.6	-0.5	0.1	1.0	-1.5	-1.7	-1.0
Medication: Ibuprofen	0.5	0.6	1.5	-1.2	-0.0	-1.2	-0.6	-0.1	0.3	-1.2	-1.1	0.5	0.5	-0.7	-0.3	-0.3
Medication: Allopurinol	0.3	0.5	2.1	-0.4	0.8	-0.9	-0.4	-1.0	-0.4	-0.7	-0.1	-0.3	1.4	0.2	-0.5	-0.2
Medication: Omeprazole	0.5	0.6	3.3	-0.5	-0.3	-0.2	-0.0	-1.7	-1.8	-0.1	-0.6	-0.8	0.4	0.0	0.1	-0.6
Medication: Seretide 50 evohaler	1.8	2.0	4.2	-0.6	-1.4	-2.1	-1.5	-1.6	-2.0	0.2	-1.3	-1.3	-1.7	1.6	1.5	0.2
Mean time to correctly identify matches	1.4	2.7	5.7	2.4	-1.0	1.4	-1.8	1.4	0.2	2.4	1.3	-0.7	-1.3	1.8	1.7	2.3
Heart disease (mother)	1.7	2.1	5.9	2.4	-0.2	0.7	0.3	2.4	1.4	1.7	2.1	-0.0	-0.3	0.6	0.5	2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.8	-0.0	-0.5	-0.6	0.3	-0.6	-0.6	0.2	-0.8	-0.7	-0.9	0.5	0.1	0.6
Whole body fat mass	0.1	0.3	0.8	0.8	0.6	0.4	-0.7	-0.5	0.0	0.3	0.1	-0.6	0.9	-0.4	-0.0	0.9
Leg fat mass (right)	0.1	0.3	1.0	0.4	0.3	-0.1	-0.9	-1.0	-0.6	-0.0	-0.2	0.0	0.9	-0.4	0.2	1.0
Arm predicted mass (right)	0.6	3.2	13.8	1.4	1.9	1.7	-1.1	1.7	3.1	0.8	1.0	0.7	3.7	-0.9	-0.6	1.2
Pulse rate, automated reading	0.1	0.4	2.1	0.2	0.7	0.0	-0.7	0.2	0.7	0.4	-0.4	-0.7	1.5	0.1	-0.6	0.3
Alcohol intake frequency.	0.2	0.4	1.9	0.0	0.3	1.4	0.6	-0.8	-0.9	-0.2	0.6	0.3	-0.4	-0.6	-0.0	0.1
Comparative height size at age 10	2.3	12.8	35.2	3.9	2.9	5.3	1.6	4.7	5.9	2.5	2.9	3.1	4.7	-2.2	-0.9	1.7
Number of full sisters	1.2	1.5	3.0	1.6	1.3	1.3	-1.5	1.4	1.7	0.7	1.3	1.0	1.0	-0.6	-1.0	0.9
Suffer from ‘nerves’	0.5	0.9	3.8	1.5	0.7	-1.5	-0.0	-0.4	-0.1	2.0	0.4	-0.7	-0.5	-0.2	-1.0	-0.5
Overall health rating	0.2	0.4	2.8	0.4	0.1	1.7	0.6	0.5	0.1	0.1	0.2	0.9	0.2	-0.4	-0.3	0.6
Chest pain or discomfort	1.3	1.9	5.7	1.4	1.6	1.9	2.4	0.4	0.5	1.2	1.5	1.1	1.9	-0.8	-1.1	0.0
Had major operations	1.1	1.3	3.3	-0.0	-1.7	-1.8	-1.0	-0.5	-1.3	-0.2	0.0	-0.8	-1.7	1.1	1.6	0.9
Age at last live birth	0.3	0.4	1.1	0.8	-0.1	-0.0	0.5	0.7	1.1	0.4	0.1	-0.4	0.4	0.9	0.8	1.0
Family relationship satisfaction	0.8	1.0	2.8	-1.2	-1.0	-1.3	-1.2	-1.4	-1.7	-0.8	-1.0	-0.4	-0.5	0.6	0.5	0.5
Leg pain on walking	0.6	0.8	1.5	1.0	-0.9	1.2	0.3	1.1	0.4	1.0	1.1	0.3	-0.7	0.8	0.9	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.3	0.3	0.5	1.5	1.2	0.9	1.2	0.9	0.2	0.5	1.0	0.7	-0.2	0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.4	0.8	0.0	-0.2	-0.4	-1.0	-1.1	1.2	0.1	-1.0	-0.6	0.7	0.3	-0.1
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	9.2	1.8	0.9	-1.4	-2.2	0.6	1.2	2.0	3.0	-1.1	0.2	-0.7	-0.7	0.5
Medication: Aspirin	1.4	1.8	6.8	1.7	0.2	0.7	1.0	2.4	1.3	1.3	2.6	-1.1	-0.2	0.0	0.5	1.4
Supplements: Vitamin C	1.0	1.2	3.2	-0.8	1.8	1.1	-0.3	0.1	1.4	-0.2	-1.1	0.8	1.4	-1.0	-1.6	-1.2
Knee pain experienced in last month	1.3	2.0	9.2	0.3	-1.8	-0.9	-1.1	-0.4	-1.1	0.8	-0.0	-0.6	-3.0	2.3	1.6	1.2
Hypertension (Self-reported)	0.2	0.6	1.4	1.2	0.2	0.7	-0.1	1.2	1.1	1.0	1.0	0.5	0.5	0.1	0.1	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	3.2	0.7	-0.6	-0.7	-0.5	0.2	-0.9	0.9	1.1	-1.8	-0.9	0.7	0.3	0.6
Illnesses of father: Heart disease	0.2	0.3	1.3	-0.1	-0.7	-1.1	-0.2	-0.4	-0.3	-0.3	0.1	-0.5	0.3	0.1	0.6	0.9
Illnesses of siblings: Diabetes	0.7	0.9	3.8	1.5	-0.4	0.2	0.9	0.2	-0.4	1.9	0.4	-0.8	-0.8	1.3	0.1	0.8
Smoking status: Previous	2.1	3.2	7.7	2.4	-1.8	0.1	0.7	2.2	0.7	2.8	1.7	-0.4	-2.6	1.7	1.8	1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.7	-0.8	0.5	0.6	1.3	-0.4	0.7	-1.3	-1.1	0.8	1.0	-1.0	-0.2	-0.3
Whole body fat-free mass	0.5	2.9	15.1	1.4	2.2	1.4	-1.3	1.2	2.7	0.8	0.9	0.3	3.9	-1.0	-0.7	0.9
Leg fat-free mass (right)	0.3	1.7	8.0	1.1	1.9	0.8	-1.2	0.7	1.9	0.8	0.6	-0.1	2.8	-0.8	-0.7	0.5
Arm fat percentage (left)	0.2	1.0	3.6	0.3	-0.6	-0.9	-0.5	-1.8	-1.9	0.1	-0.2	-1.4	-1.2	0.4	0.4	0.8
Average weekly red wine intake	0.5	0.8	2.9	0.7	-0.9	-1.7	0.2	0.3	0.0	0.6	-0.4	-0.8	-0.9	1.2	1.2	0.9
Handedness (chirality/laterality): Left-handed	0.2	0.2	1.2	-1.1	0.0	-0.0	-0.7	-0.3	-0.0	-0.5	-0.7	0.0	0.1	-0.3	-0.0	-0.6
Mood swings	1.0	1.7	9.8	-0.2	0.9	-3.1	0.3	-1.9	-2.1	-0.4	0.3	-1.1	0.4	-0.9	-0.7	-1.1
Loneliness, isolation	0.3	0.4	2.1	-0.4	-0.3	0.5	1.4	-0.7	-0.7	-0.1	-0.2	1.1	-0.8	0.3	-0.0	-0.3
Long-standing illness, disability or infirmity	1.1	1.7	4.8	1.8	-0.6	2.2	2.2	0.7	0.2	1.4	0.9	0.1	-0.7	1.2	0.8	1.9
Ever had bowel cancer screening	0.5	0.6	2.2	-0.6	-0.0	-0.0	0.5	-0.6	-1.4	-1.3	-1.5	-0.3	0.4	-0.6	-0.2	-0.6
Diabetes diagnosed by doctor	1.2	1.9	4.4	2.0	1.0	1.9	-0.2	1.7	1.7	2.1	1.2	0.2	1.1	0.7	0.1	1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	3.1	0.1	0.3	-1.4	-1.8	-0.8	-1.0	0.1	-0.8	-1.6	0.3	0.4	-0.2	0.5
Friendships satisfaction	0.7	0.8	3.4	-0.3	0.4	-1.4	0.2	-1.9	-1.5	-0.4	-0.3	-0.2	0.6	-1.2	-0.9	-0.0
Qualifications: nursing, teaching	0.5	0.7	3.4	-0.3	1.3	-0.1	-1.8	-0.9	-0.7	0.0	-0.8	0.4	0.9	-0.4	-1.0	-0.7
Commuting to job workplace: Walk	1.3	1.4	3.5	1.1	0.9	0.8	0.4	1.6	1.9	1.0	1.2	1.6	1.6	-0.2	-0.1	1.2
Eye problems/disorders: Cataract	3.5	4.1	9.9	2.5	0.3	2.4	0.9	2.7	2.5	1.6	2.5	3.1	1.2	-0.2	0.4	2.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.0	-0.4	-0.5	-0.6	-1.4	-0.8	-0.8	-0.6	-1.3	-0.1	-0.9	0.7	-0.0	0.0
Medication for cholesterol	0.3	0.5	2.4	0.6	-0.3	-0.5	1.1	-0.1	0.2	0.2	0.6	-1.6	-0.9	0.4	0.3	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	4.6	-1.7	-0.1	-1.2	-1.0	-1.0	-0.8	-2.2	-1.0	-0.0	0.2	-0.9	-0.3	-0.3
Back pain experienced in last month	0.9	1.3	5.6	0.5	0.7	1.4	1.6	1.1	1.6	0.7	1.1	0.5	2.4	-0.1	0.1	0.4
Mineral and other dietary supplements	0.4	0.6	1.7	0.3	1.0	0.5	-0.3	-0.4	-0.3	0.2	0.7	-0.9	1.3	-0.6	-1.0	-1.0
Breast cancer (self-reported)	0.5	0.6	2.2	0.5	-0.5	-1.1	1.2	-0.9	-1.5	0.3	0.3	-0.7	-1.1	0.2	-0.3	-0.2
Asthma (self-reported)	0.8	1.6	3.5	1.6	-0.2	0.6	-0.5	1.8	1.9	1.8	1.8	-1.0	-0.7	1.2	0.5	1.0
Osteoporosis (self-reported)	0.8	1.0	2.6	-0.8	-1.6	1.1	0.8	1.4	0.5	-1.1	-0.7	0.9	-0.3	0.8	1.4	0.3
Osteoarthritis (self-reported)	1.0	1.3	7.4	0.1	0.2	-1.9	0.4	-2.7	-1.9	0.4	-1.0	0.2	0.0	-0.0	-0.5	-0.3
Medication: Aspirin	1.5	2.0	6.1	1.8	0.3	1.0	1.5	2.5	1.5	1.5	2.4	-0.9	0.2	-0.1	0.3	1.4
Medication: Gliclazide	0.9	1.0	2.0	0.8	0.9	1.4	-1.3	1.4	1.2	-0.1	0.0	1.2	1.4	-0.4	0.0	0.8
Illnesses of father: None of the above (group 1)	0.2	0.3	1.8	-0.2	0.4	1.3	1.0	-0.2	0.1	0.0	0.2	0.3	-0.3	0.3	-0.2	-0.6
Smoking status: Current	0.8	1.3	5.5	-0.5	1.5	-0.2	0.4	-0.2	0.4	-1.4	-1.1	0.8	2.3	-1.7	-1.3	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	4.8	11.3	-2.7	-1.6	-3.3	-0.4	-3.1	-3.4	-3.2	-3.0	-1.2	-0.5	-0.4	0.4	-0.3
Whole body water mass	0.5	3.0	14.3	1.5	2.1	1.4	-1.3	1.4	2.8	0.9	1.0	0.3	3.8	-0.9	-0.6	1.1
Leg predicted mass (right)	0.3	1.7	7.8	1.2	1.9	0.8	-1.2	0.6	1.9	0.9	0.6	-0.1	2.8	-0.8	-0.8	0.6
Arm fat mass (left)	0.1	0.3	1.0	0.5	0.3	-0.2	-0.7	-1.0	-0.5	0.2	-0.1	-0.7	0.4	-0.1	-0.0	0.9
Number of self-reported non-cancer illnesses	0.6	1.1	3.3	1.6	-0.7	0.9	0.1	0.8	0.3	1.8	1.1	-0.1	-0.2	1.3	1.1	1.5
Average weekly champagne plus white wine intake	0.4	0.6	3.7	-0.1	0.5	1.5	-0.2	0.6	0.9	0.0	-0.1	-1.9	0.2	0.2	-0.2	-0.3
Miserableness	0.7	1.2	3.3	-1.0	0.6	-1.2	0.8	-1.8	-1.6	-1.1	-1.4	-0.6	0.3	-0.7	-0.5	-1.1
Guilty feelings	0.6	0.9	7.8	0.4	0.2	0.2	2.8	0.6	0.4	0.1	0.2	0.8	1.0	-0.9	-0.6	0.4
Wears glasses or contact lenses	0.6	0.7	3.6	1.0	-0.7	-0.8	-0.7	0.6	0.2	0.1	0.2	1.6	0.6	0.1	0.1	1.9
Ever taken oral contraceptive pill	1.4	1.6	6.8	0.4	1.0	2.1	0.8	0.6	0.5	-0.7	-0.3	1.0	2.6	-1.8	-1.2	1.0
Hearing aid user	0.8	0.9	5.6	-1.3	-0.4	-2.4	-1.0	-0.8	-1.0	-0.6	-0.1	-0.4	-0.8	0.6	0.5	-0.3
Mother’s age at death	0.6	0.7	2.8	-0.3	-0.2	-0.9	1.7	-1.0	-0.8	-0.5	-1.3	-1.2	0.6	0.2	-0.1	-0.0
Financial situation satisfaction	0.7	0.8	3.3	-0.3	-0.5	-1.8	-0.8	-1.6	-1.4	-0.6	-1.2	-0.1	-0.2	-0.2	-0.1	-0.0
Tinnitus: Yes, now most or all of the time	1.1	1.2	3.8	-1.3	-0.7	-1.9	-1.2	-1.5	-1.9	-1.0	-1.2	-0.1	-0.1	0.3	0.5	-0.1
Commuting to job workplace: Public transport	0.3	0.3	1.7	0.1	0.6	1.3	0.3	-0.2	0.5	-0.4	-0.3	0.3	0.5	-0.5	-0.9	-0.6
Eye problems/disorders: Glaucoma	0.7	0.8	2.6	0.9	0.2	1.1	-0.7	1.6	1.4	1.1	0.2	0.5	-0.4	0.8	-0.4	1.2
Medication: Blood pressure	0.2	0.3	1.7	-1.2	-0.0	-0.2	-0.8	0.3	0.0	-0.1	-0.3	-0.0	0.4	-0.3	0.3	-1.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	3.5	-0.4	0.2	-0.2	1.0	-1.9	-1.5	-0.4	-0.3	-0.4	-0.6	0.1	-0.6	-0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.1	-0.4	-0.4	-1.0	-0.4	-0.1	-0.0	-0.4	-0.3	1.0	-1.0	-0.6	0.1	0.5
High cholesterol (Self-reported)	0.9	1.6	4.8	2.2	-0.0	0.0	-1.0	0.7	0.0	2.1	2.2	-1.0	0.2	1.0	1.0	1.5
Medication: Bendroflumethiazide	0.8	1.3	4.6	1.3	0.6	1.0	-0.0	1.8	1.7	2.1	1.4	-0.2	0.4	0.5	-0.3	0.2
Medication: Paracetamol	0.2	0.4	2.1	1.2	-0.3	-0.0	0.5	0.4	0.1	0.5	0.2	-0.3	-0.2	-0.1	0.3	1.4
Medication: Lisinopril	0.5	0.7	4.0	-0.4	1.1	-0.6	-0.3	0.3	0.3	-0.4	0.3	0.2	2.0	-1.2	-1.0	-0.6
Medication: Atorvastatin	1.0	1.2	4.7	-0.2	-1.5	0.9	0.6	0.9	-0.0	0.6	0.7	-0.6	-1.1	1.8	2.2	1.2
Illnesses of father: High blood pressure	1.1	1.4	3.2	0.8	-0.8	-0.2	-1.0	1.3	0.6	1.3	0.8	-1.8	-1.7	1.6	1.5	0.0
Alcohol drinker status: Never	0.9	1.0	2.9	-1.2	0.9	1.0	0.2	-1.7	-1.4	-1.1	-0.8	-1.2	-0.4	0.5	-0.9	-0.9
Ever smoked	1.0	1.8	5.4	2.3	-0.9	0.1	0.6	2.0	0.9	1.2	1.7	0.5	-1.1	0.6	1.2	2.2
Basal metabolic rate	0.4	2.2	11.6	1.2	1.9	1.2	-1.3	0.9	2.3	0.7	0.7	0.2	3.4	-0.9	-0.5	0.9
Leg fat percentage (left)	0.4	1.4	5.4	-0.5	-0.8	-1.4	-1.4	-2.1	-2.3	-0.8	-1.0	-0.4	-0.7	0.1	0.6	0.8
Arm fat-free mass (left)	0.5	2.7	13.2	1.3	2.0	1.3	-1.6	1.1	2.6	0.7	0.6	0.4	3.6	-0.9	-0.6	1.1
Number of operations (self-reported)	1.1	1.7	3.6	-0.9	-1.3	-1.0	-1.1	-1.9	-1.7	-0.5	-1.9	-0.6	-1.9	1.4	1.0	0.1
Average weekly beer plus cider intake	1.0	1.4	4.9	-0.1	1.5	0.6	1.6	-0.3	0.1	-0.8	0.5	1.1	1.8	-1.6	-2.2	-0.3
Irritability	0.8	1.4	6.2	2.5	1.2	0.7	0.3	0.1	0.1	2.1	2.1	-0.2	0.3	-0.6	-0.4	0.6
Risk taking	0.7	1.1	3.7	-1.9	0.2	-0.6	-0.7	-1.2	-0.8	-1.9	-1.1	-0.2	-0.6	-0.7	-0.3	-1.4
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.4	1.2	-0.5	-1.8	-1.8	0.4	-0.0	0.7	0.4	-1.4	-0.5	1.5	1.1	1.5
Fractured/broken bones in last 5 years	1.1	1.5	2.8	1.7	-0.8	-1.2	-1.4	0.5	-0.6	1.5	0.7	-1.3	-1.0	1.6	1.4	1.1
Age started oral contraceptive pill	0.4	0.5	1.5	1.1	0.5	1.1	0.1	0.9	0.5	1.2	0.7	-0.1	0.2	-0.4	-1.0	-0.7
Diastolic blood pressure, automated reading	0.3	1.1	2.4	0.3	1.5	-0.7	0.1	-0.6	0.3	0.2	1.6	1.0	1.5	-1.5	-1.2	-1.0
Ever depressed for a whole week	0.1	0.2	0.8	-0.2	-0.1	-0.6	-0.5	-0.6	-0.2	0.0	0.1	0.9	-0.0	-0.3	-0.3	0.5
Unable to work because of sickness or disability	0.3	0.4	1.6	-0.1	-0.4	-0.3	0.2	-0.5	-1.1	0.1	0.4	-0.8	-0.4	1.3	0.3	0.7
Commuting to job workplace: Cycle	0.3	0.4	1.4	-0.9	-0.5	-1.2	-0.8	-0.4	-0.6	-0.5	0.3	-0.3	-0.7	0.9	0.4	0.0
Myopia	0.4	0.6	1.3	1.0	0.6	0.2	-1.1	1.0	1.1	1.0	0.2	0.8	0.9	0.6	0.7	0.3
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.0	-0.8	-0.2	-0.9	0.5	-0.8	-0.8	-0.8	-0.6	-0.8	-1.0	-0.0	-0.3	-0.3
Cholesterol lowering medication	0.3	0.4	1.2	-0.1	-0.9	0.5	-0.9	-0.1	-0.8	0.2	-0.5	-0.0	-0.4	0.8	1.1	0.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	3.8	-0.3	-0.2	-0.2	-0.5	-1.4	-1.9	0.4	-0.3	-1.3	-0.1	-0.0	-0.2	-0.9
Pain experienced in last month	0.3	0.4	2.9	0.4	0.5	0.1	-1.7	0.3	0.6	-0.3	-0.3	-0.7	-0.1	-0.4	-1.0	-0.4
Supplements: Calcium	0.5	0.6	3.0	0.2	0.2	0.4	-0.8	-0.8	-0.9	-0.3	-1.7	1.0	0.3	0.4	-0.6	0.6
Basal cell carcinoma (self-reported)	0.5	0.6	1.5	-1.1	-0.4	-0.6	-1.1	-0.8	-0.7	-1.0	-1.2	-0.6	-0.4	0.5	0.7	-0.6
Heart attack/myocardial infarction (self-reported)	0.8	1.1	4.5	2.1	-0.4	1.0	-0.1	-0.6	-0.8	1.1	0.0	-0.6	-1.1	0.7	0.2	1.9
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.1	-0.3	-1.2	-1.0	-1.5	-0.1	-0.7	0.4	0.2	-0.9	-0.8	1.2	1.3	0.8
Heart disease (siblings)	0.8	1.0	3.0	0.6	1.4	0.1	0.3	0.3	0.3	0.1	0.5	1.0	1.7	-1.7	-1.7	0.0
Alcohol drinker status: Previous	1.0	1.1	4.5	1.3	-1.3	0.4	0.9	0.5	-0.3	1.2	1.6	-0.5	-0.6	0.1	1.1	2.1
Pack years of smoking	1.7	2.6	8.2	1.0	-2.2	1.0	0.7	1.2	0.0	0.6	1.5	0.4	-1.6	2.4	2.2	2.9
Impedance of whole body	0.2	0.9	3.2	0.0	-0.7	1.5	0.8	1.8	1.0	0.1	0.8	-0.2	-1.3	-0.3	0.6	-1.1
Leg fat mass (left)	0.1	0.4	1.2	0.4	0.4	-0.1	-1.1	-1.1	-0.6	0.0	-0.3	-0.0	0.9	-0.3	0.0	1.0
Arm predicted mass (left)	0.4	2.2	11.0	1.2	1.6	1.3	-1.5	1.0	2.4	0.8	0.4	0.3	3.3	-0.6	-0.3	1.2