TWAS
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Models
Genes
Traits
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Traits
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Hypothyroidism (self reported)
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chr6:35,216,296-35,942,313
Best TWAS P=9.12e-11 · Best GWAS P=2.74e-10 conditioned to 0.0436
35.2M
35.3M
35.4M
35.5M
35.6M
35.7M
35.8M
35.9M
0
2
4
6
8
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Pancreatic Adenocarcinoma
TULP1
0.09
0.02
blup
58
0.02
6.1e-02
-5.7
-6.5
9.1e-11
0.78
0.01
0.76
TRUE
1
The Cancer Genome Atlas
Lung Adenocarcinoma
FKBP5
0.04
0.05
lasso
2
0.04
5.4e-05
5.9
5.8
5.0e-09
-0.50
0.02
0.96
FALSE
3
The Cancer Genome Atlas
Prostate Adenocarcinoma
TULP1
0.09
0.06
lasso
4
0.07
6.2e-08
5.9
-5.7
1.3e-08
0.64
0.00
1.00
FALSE