TWAS hub - TULP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Pancreatic Adenocarcinoma	0.0890	0.0490	9.2e-03	0.018	0.017	0.017	NA	0.003	5.7e-02	6.1e-02	6.5e-02	NA	2.4e-01
2	TCGA	Prostate Adenocarcinoma	0.0852	0.0353	6.8e-07	0.056	0.068	0.065	NA	0.071	1.5e-06	1.3e-07	2.4e-07	NA	6.2e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hypothyroidism/myxoedema (self-reported)	17.0	33.2	37.7	-6.1	-5.3
Hypothyroidism (self reported)	16.2	37.1	42.0	-6.5	-5.7
Medication: Levothyroxine sodium	12.2	20.6	22.5	-4.7	-4.3
Mouth/teeth dental problems: Bleeding gums	7.9	10.2	12.0	2.9	3.5
Pulse wave reflection index	7.6	9.3	10.0	3.0	3.2
Eye problems/disorders: Glaucoma	5.1	6.1	6.3	-2.5	-2.4
Lung FVC	4.8	24.2	25.8	5.1	4.8
HDL Cholesterol	4.5	7.4	9.4	3.1	2.3
Trunk fat mass	3.9	16.7	19.3	-4.4	-3.8
Back pain experienced in last month	3.9	5.6	6.4	-2.5	-2.2
Bipolar Disorder (2011)	3.7	3.6	4.2	-1.7	-2.0
Whole body fat mass	3.7	15.5	17.5	-4.2	-3.7
Trunk fat percentage	3.5	14.0	17.0	-4.1	-3.3
Worrier / anxious feelings	3.5	6.6	7.7	-2.8	-2.3
Body fat percentage	3.5	13.8	16.5	-4.1	-3.3
Leg fat mass (right)	3.4	13.3	14.7	-3.8	-3.5
Number of self-reported non-cancer illnesses	3.3	5.7	6.3	-2.5	-2.3
Leg fat mass (left)	3.3	12.7	14.1	-3.8	-3.4
Reason for reducing amount of alcohol drunk: Health precaution	3.2	3.7	5.5	1.4	2.3
Long-standing illness, disability or infirmity	3.2	4.9	5.3	-2.3	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.2	6.7	6.8	2.6	2.6
Glaucoma (self-reported)	3.1	3.7	3.7	-1.9	-1.9
Leg fat percentage (right)	3.1	11.4	13.2	-3.6	-3.1
Medication: Amlodipine	3.0	4.2	4.5	-2.1	-2.0
Leg fat percentage (left)	3.0	10.7	12.6	-3.5	-3.0
Number of incorrect matches in round	2.9	4.8	4.9	-2.2	-2.2
Weight	2.9	14.4	15.9	-4.0	-3.6
Waist circumference	2.8	10.4	12.5	-3.5	-2.9
Ovarian Cancer	2.7	3.5	4.1	1.7	2.0
Breastfed as a baby	2.7	3.4	3.6	1.9	1.8
Pulse wave peak to peak time	2.7	3.2	3.7	-1.6	-1.9
Lung cancer (father)	2.6	3.0	4.3	-2.1	-1.3
Illnesses of father: High blood pressure	2.5	3.2	3.3	1.7	1.8
Age started oral contraceptive pill	2.5	3.1	3.1	-1.8	-1.8
Illnesses of father: None of the above (group 1)	2.4	3.0	4.2	-2.1	-1.3
Taking other prescription medications	2.3	3.6	3.7	-1.9	-1.9
Hip circumference	2.3	9.7	10.5	-3.2	-3.0
Pulse wave Arterial Stiffness index	2.3	2.6	3.2	1.4	1.8
Arm fat mass (right)	2.3	9.3	10.0	-3.2	-2.9
Osteoarthritis (self-reported)	2.3	3.0	3.3	1.8	1.6
Rheumatoid Arthritis	2.2	3.1	3.5	-1.6	-1.9
Hand grip strength (right)	2.2	5.9	6.4	-2.5	-2.3
Alcohol intake versus 10 years previously	2.2	3.3	4.5	-1.4	-2.1
Arm fat mass (left)	2.2	8.9	9.7	-3.1	-2.8
Type 2 Diabetes (T2D) (2012)	2.1	2.4	3.1	-1.8	-1.3
Blood White Count	2.1	15.2	20.2	-3.2	-4.5
Medication for cholesterol, blood pressure or diabetes	2.1	3.4	4.5	2.1	1.5
Arm predicted mass (right)	2.1	11.0	11.7	-3.4	-3.2
Arm fat-free mass (left)	2.1	10.8	11.5	-3.4	-3.2
Time employed in main current job	2.0	2.3	3.0	-1.7	-1.2
Arm fat-free mass (right)	2.0	10.4	11.1	-3.3	-3.1
Medication: Ibuprofen	2.0	2.4	2.8	-1.7	-1.4
Illnesses of siblings: Diabetes	2.0	2.5	3.2	1.8	1.3
Cardiovascular Disease	1.9	6.3	7.0	-2.6	-2.4
Hair/balding pattern: Pattern 3	1.9	2.8	2.9	1.6	1.7
Neck or shoulder pain in last month	1.9	2.7	3.0	-1.7	-1.5
Handedness (chirality/laterality): Left-handed	1.9	2.3	3.1	1.8	1.2
High cholesterol (Self-reported)	1.9	3.4	4.0	-2.0	-1.7
Arm predicted mass (left)	1.9	9.7	10.1	-3.2	-3.0
Chronotype (morning person)	1.8	4.1	4.9	2.2	1.8
Arm fat percentage (right)	1.8	7.1	7.8	-2.8	-2.5
Basal metabolic rate	1.8	10.0	10.4	-3.2	-3.1
Hearing difficulty/problems with background noise	1.7	2.7	3.1	1.5	1.8
Hair/balding pattern: Pattern 2	1.7	2.2	2.3	-1.5	-1.4
Medication: Cholesterol lowering	1.7	2.7	4.2	-2.0	-1.1
Medication for pain relief, constipation, heartburn	1.7	2.9	4.7	2.2	1.1
Arm fat percentage (left)	1.7	6.9	7.8	-2.8	-2.4
Irritable Bowel Disease (IBD)	1.6	3.8	4.3	-2.1	-1.8
Leg fat-free mass (left)	1.6	8.3	8.5	-2.9	-2.9
High blood pressure	1.6	4.6	5.0	-2.0	-2.2
Leg predicted mass (left)	1.6	8.5	8.8	-3.0	-2.9
Prospective memory result	1.6	2.0	2.5	1.2	1.6
Qualifications: O levels/GCSEs or equivalent	1.6	2.6	2.6	1.6	1.6
Number of full sisters	1.6	1.9	2.7	1.6	1.1
Knee pain experienced in last month	1.6	2.5	2.8	-1.5	-1.7
Birth weight	1.5	3.2	4.9	1.2	2.2
Medication: Blood pressure	1.5	2.7	3.4	-1.9	-1.4
Tinnitus: Yes, now most or all of the time	1.5	1.8	2.3	1.1	1.5
Crohns Disease (2017)	1.4	3.1	3.8	-2.0	-1.5
Medication: Atenolol	1.4	1.7	2.3	-1.5	-1.1
High blood pressure (mother)	1.4	2.0	2.8	1.7	1.1
Body mass index (BMI)	1.4	5.8	6.6	-2.6	-2.2
Whole body fat-free mass	1.4	8.0	8.1	-2.9	-2.8
Commuting to job workplace: Walk	1.4	1.5	1.8	-1.1	-1.4
Supplements: Fish oil (including cod liver oil)	1.4	1.9	2.3	1.2	1.5
Father’s age at death	1.3	1.7	2.4	-1.6	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.2	4.5	2.0	2.1
Comparative body size at age 10	1.3	3.5	3.6	1.8	1.9
Leg fat-free mass (right)	1.3	7.1	7.2	-2.7	-2.6
Eye problems/disorders: Cataract	1.3	1.5	2.2	0.9	1.5
Whole body water mass	1.3	7.5	7.7	-2.8	-2.7
Leg predicted mass (right)	1.3	6.9	7.2	-2.7	-2.6
Fractured/broken bones in last 5 years	1.3	1.7	2.1	-1.1	-1.5
Vascular/heart problems diagnosed by doctor	1.3	3.6	3.9	2.0	1.8
Basal cell carcinoma (self-reported)	1.3	1.6	1.6	-1.2	-1.2
Hand grip strength (left)	1.2	3.2	3.8	-1.9	-1.6
Supplements: Glucosamine	1.2	1.6	2.3	1.5	1.0
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	1.4	1.2	1.2
Medication: Simvastatin	1.2	1.8	1.9	-1.4	-1.3
Supplements: Vitamin C	1.2	1.4	2.0	-1.4	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	1.7	-1.0	-1.3
Illnesses of father: Heart disease	1.2	1.7	2.2	1.1	1.5
Medication: Bendroflumethiazide	1.2	1.8	3.2	-0.7	-1.8
Body Mass Index (BMI) (2010)	1.1	1.5	2.0	-1.4	-1.0
Number of treatments/medications taken	1.1	2.0	2.5	-1.6	-1.2
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.3	-1.5	-0.7
Had menopause	1.1	1.4	1.8	-1.0	-1.3
Heart attack	1.1	1.4	2.4	-1.5	-0.7
Trunk fat-free mass	1.1	6.2	6.2	-2.5	-2.5
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	3.8	2.0	1.9
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	2.1	1.5	0.6
Trunk predicted mass	1.1	6.4	6.5	-2.5	-2.5
Qualifications: College or University degree	1.1	3.4	4.3	2.1	1.6
Emphysema/chronic bronchitis	1.1	1.2	1.4	-1.1	-1.2
Hypertension (Self-reported)	1.1	3.2	3.3	-1.7	-1.8
Financial situation satisfaction	1.1	1.4	1.7	-1.0	-1.3
Pain experienced in last month	1.1	1.9	2.0	1.4	1.3
Heart disease (siblings)	1.1	1.4	1.7	-1.3	-1.0
Crohns Disease (2012)	1.0	1.6	2.1	-1.4	-1.1
Height	1.0	19.1	19.3	-4.4	-4.4
Allergy or Eczema	1.0	2.5	3.0	-1.7	-1.4
Chronic bronchitis/emphysema (father)	1.0	1.2	1.7	-0.8	-1.3
Medication: Paracetamol	1.0	1.6	2.3	-1.5	-1.0
Forced vital capacity (FVC), Best measure	1.0	3.8	3.9	2.0	1.9
Average weekly fortified wine intake	0.9	1.0	1.5	0.7	1.2
Age when periods started (menarche)	0.9	2.2	2.9	1.7	1.2
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.2	-1.1	-0.9
Forced vital capacity (FVC)	0.9	3.4	3.7	1.9	1.7
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	1.7	-1.1	-1.3
Standing height	0.9	9.0	9.6	-3.1	-2.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	1.4	-0.9	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.2	-1.0	-1.1
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.1	-1.4	-0.5
Schizophrenia vs Biploar Disorder	0.8	1.0	1.3	0.9	1.1
LDL Cholesterol	0.8	1.2	1.7	0.9	1.3
BMI	0.8	4.9	5.9	-2.4	-2.0
Townsend deprivation index at recruitment	0.8	1.2	1.4	-1.2	-1.0
Financial difficulties in last 2 years	0.8	1.0	1.4	-1.2	-0.8
Illnesses of mother	0.8	1.0	1.1	1.0	0.9
High blood pressure (siblings)	0.8	1.2	1.5	-1.2	-1.0
Family relationship satisfaction	0.8	1.0	1.5	1.2	0.7
Medication: Aspirin	0.8	1.0	1.7	-1.3	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	0.9	-0.9	-0.9
Wears glasses or contact lenses	0.8	1.0	1.2	-1.1	-0.8
Mother’s age at death	0.8	1.0	1.1	-1.0	-1.1
Medication: Paracetamol	0.8	1.3	1.8	-1.4	-0.9
Supplements: Calcium	0.8	0.9	1.0	-1.0	-0.8
Bipolar Disorder (2018)	0.7	1.1	1.1	-1.1	-1.1
Bipolar Disorder or Schizophrenia	0.7	1.7	1.8	-1.4	-1.2
Depression (Nagel 2018)	0.7	1.1	1.5	-1.2	-0.9
Ulcerative Colitis (UC)	0.7	1.4	1.4	-1.2	-1.2
Smoking Status	0.7	1.6	2.1	-1.1	-1.4
Average weekly spirits intake	0.7	0.9	1.3	-1.1	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.1	-1.0	-0.8
Relative age voice broke	0.7	1.0	1.6	-0.7	-1.3
Qualifications: CSEs or equivalent	0.7	0.9	1.1	1.0	0.8
Pain all over the body in last month	0.7	0.8	1.3	0.4	1.2
Pulse rate	0.7	1.2	1.2	-1.1	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	0.9	-1.0	-0.9
Medication: Lansoprazole	0.7	0.8	1.0	0.8	1.0
Headache pain in last month	0.7	1.1	1.4	-1.2	-0.9
Gout (self-reported)	0.7	0.9	1.6	-1.3	-0.4
Breast cancer (self-reported)	0.7	0.8	1.1	-0.7	-1.1
Alcohol drinker status: Never	0.7	0.9	1.0	-0.9	-1.0
Sensitivity / hurt feelings	0.6	1.0	1.7	-1.3	-0.6
Medication: Co-codamol	0.6	0.7	1.2	-0.4	-1.1
Severe depression (siblings)	0.6	0.7	1.0	-1.0	-0.5
Pack years adult smoking proportion	0.6	0.9	1.1	-1.0	-0.9
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	0.9	1.0	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	2.3	-1.5	-0.8
Noisy workplace	0.6	0.7	1.0	0.7	1.0
Number of children fathered	0.6	0.7	0.9	-1.0	-0.7
Medication: Omeprazole	0.6	0.7	0.8	-0.9	-0.7
Hearing aid user	0.6	0.7	0.8	0.7	0.9
Medication: Blood pressure	0.6	1.1	1.2	-1.0	-1.1
Commuting to job workplace: Cycle	0.6	0.7	0.9	-0.7	-1.0
Alzheimer’s Disease (in mother)	0.5	0.6	0.8	-0.5	-0.9
Alzheimer’s Disease (in father)	0.5	0.5	0.8	0.9	0.5
Breast Cancer	0.5	1.1	1.3	-0.9	-1.1
Ulcerative Colitis	0.5	0.8	0.8	-0.9	-0.9
Medication for hormone replacement therapy	0.5	0.5	0.9	-0.3	-1.0
Maternal smoking around birth	0.5	0.7	0.8	0.9	0.8
Sitting height	0.5	3.8	5.0	-2.2	-1.6
Qualifications: None of the above	0.5	1.2	1.7	-1.3	-0.8
Impedance of arm (right)	0.5	2.2	2.3	1.5	1.4
Tense / ‘highly strung’	0.5	0.8	1.1	-1.1	-0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.0	1.0	0.4
Angina (self-reported)	0.5	0.7	1.3	-1.1	-0.1
Chest pain or discomfort	0.5	0.7	1.2	-1.1	-0.5
Ever had bowel cancer screening	0.5	0.6	0.6	0.8	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	0.7	0.8	0.6
Mineral and other dietary supplements	0.5	0.6	0.8	-0.7	-0.9
Average weekly beer plus cider intake	0.5	0.8	1.1	1.0	0.6
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.2	-1.1	-0.4
Ever had hysterectomy (womb removed)	0.4	0.5	0.5	-0.6	-0.7
Angina	0.4	0.5	1.1	-1.0	0.0
Diabetes (father)	0.4	0.5	0.5	0.7	0.6
Multivitamins +/- minerals	0.4	0.5	0.5	0.6	0.7
Stomach or abdominal pain in last month	0.4	0.6	0.6	-0.7	-0.8
Diabetes (self-reported)	0.4	0.6	0.9	-0.4	-1.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.7	-0.8	-0.6
Hair/balding pattern: Pattern 4	0.4	0.9	1.0	1.0	1.0
Age at last live birth	0.4	0.5	0.8	-0.9	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.7	-0.6	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.4	-1.2	-0.6
Mood swings	0.4	0.7	0.8	-0.8	-0.9
Loneliness, isolation	0.4	0.5	0.8	0.5	0.9
Friendships satisfaction	0.4	0.5	0.8	0.9	0.5
Medication for cholesterol	0.4	0.5	1.0	0.2	1.0
Medication: Aspirin	0.4	0.6	1.1	-1.0	-0.3
Medication: Lisinopril	0.4	0.6	1.0	-0.4	-1.0
Irritability	0.4	0.8	1.1	-1.1	-0.6
Myopia	0.4	0.5	1.1	1.0	-0.1
Pack years of smoking	0.4	0.7	0.7	-0.8	-0.8
Neuroticism (Nagel 2018)	0.3	0.7	1.3	-1.1	-0.3
Schizophrenia (2018)	0.3	0.6	0.7	-0.8	-0.7
Major Depression (MDD)	0.3	0.4	0.5	0.4	-0.7
Fasting Glucose	0.3	0.4	0.5	-0.6	-0.7
Triglycerides	0.3	0.5	0.9	-1.0	0.4
Waist Hip Ratio (WHR)	0.3	1.2	2.0	-1.4	-0.6
Systolic blood pressure, automated reading	0.3	0.8	1.5	1.2	0.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.6	-0.8	-0.7
Nervous feelings	0.3	0.5	0.5	0.7	0.7
Mouth/teeth dental problems	0.3	0.4	0.5	-0.7	-0.6
Fluid intelligence score	0.3	0.5	0.7	0.9	0.6
Mouth/teeth dental problems: Dentures	0.3	0.6	0.9	-0.4	-1.0
Length of working week for main job	0.3	0.3	0.4	0.6	0.6
Blood clot in the leg (DVT)	0.3	0.4	0.8	-0.9	-0.0
Exposure to tobacco smoke outside home	0.3	0.5	0.8	-0.3	-0.9
Worry too long after embarrassment	0.3	0.5	0.9	-0.9	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.5	-0.7	-0.5
Eye problems/disorders: None of the above	0.3	0.3	0.5	0.7	0.3
Alcohol intake frequency.	0.3	0.8	1.1	-0.6	-1.1
Overall health rating	0.3	0.6	0.6	-0.8	-0.8
Average weekly red wine intake	0.3	0.5	0.6	0.8	0.6
Medication: Gliclazide	0.3	0.3	0.4	-0.4	-0.7
Smoking status: Current	0.3	0.4	0.6	-0.8	-0.5
Ever taken oral contraceptive pill	0.3	0.3	0.4	-0.5	-0.7
Medication: Atorvastatin	0.3	0.3	0.5	0.4	0.7
Ever depressed for a whole week	0.3	0.4	0.6	-0.4	-0.8
Alcohol drinker status: Previous	0.3	0.4	0.7	0.3	0.8
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.5	-0.7	-0.7
Mean Putamen Volume	0.2	0.3	0.5	0.3	-0.7
HbA1C	0.2	0.2	0.3	-0.5	-0.2
Blood Platelet Count	0.2	2.0	2.5	1.6	1.3
Heel T-Score	0.2	1.6	2.3	0.9	1.5
Systolic Blood Pressure	0.2	0.9	1.7	1.3	0.3
Hair Pigment	0.2	4.4	4.5	-2.1	-2.1
Tanning	0.2	2.4	3.2	1.3	1.8
Supplements: Zinc	0.2	0.2	0.4	0.6	0.3
Medication: Metformin	0.2	0.3	0.3	-0.5	-0.5
Current tobacco smoking	0.2	0.3	0.5	-0.7	-0.3
Had other major operations	0.2	0.3	0.5	0.7	0.3
Medication: Ramipril	0.2	0.2	0.3	-0.6	0.3
Asthma	0.2	0.4	0.5	0.7	0.5
Loud music exposure frequency	0.2	0.2	0.3	-0.4	-0.5
Health satisfaction	0.2	0.3	0.3	-0.5	-0.6
Medication: Allopurinol	0.2	0.3	0.6	-0.8	-0.1
Medication: Seretide 50 evohaler	0.2	0.2	0.2	-0.5	-0.4
Comparative height size at age 10	0.2	1.1	1.3	-1.1	-1.0
Had major operations	0.2	0.3	0.3	-0.5	-0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.2	-0.5	-0.4
Diabetes diagnosed by doctor	0.2	0.3	0.6	-0.2	-0.8
Risk taking	0.2	0.3	0.5	0.1	0.7
Cholesterol lowering medication	0.2	0.3	0.3	0.6	0.6
Depressed Affect (Nagel 2018)	0.1	0.2	0.2	-0.5	-0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	0.3	0.5
Age at First Birth	0.1	0.1	0.2	-0.2	-0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.1	-0.4	-0.1
Primary Biliary Cirrhosis	0.1	0.2	0.2	0.4	0.4
Blood Eosinophil Count	0.1	0.6	0.9	-0.9	0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	-0.4	-0.3
Lung FEV1/FVC ratio	0.1	0.5	1.0	0.0	1.0
Neuroticism	0.1	0.1	0.3	-0.5	-0.1
Relative age of first facial hair	0.1	0.2	0.4	0.6	-0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.4	-0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.5	-0.1
Diabetes (mother)	0.1	0.1	0.3	-0.1	-0.5
Fed-up feelings	0.1	0.2	0.4	-0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	-0.8	0.1
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.2	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.1	0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.3	0.5	-0.3
Illnesses of siblings	0.1	0.2	0.3	-0.5	-0.3
Neuroticism score	0.1	0.2	0.4	-0.6	-0.3
Falls in the last year	0.1	0.1	0.2	0.4	0.0
Number of live births	0.1	0.2	0.3	-0.6	-0.2
Happiness	0.1	0.2	0.3	0.6	-0.1
Depression (self-reported)	0.1	0.1	0.2	-0.1	-0.4
Impedance of arm (left)	0.1	0.5	0.7	0.6	0.8
Exposure to tobacco smoke at home	0.1	0.2	0.2	-0.4	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.1	0.2	0.3
Birth weight of first child	0.1	0.2	0.4	0.1	0.7
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	0.5	0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.4	0.0
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.0	0.5
Number of full brothers	0.1	0.2	0.4	-0.6	-0.0
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	0.6	0.3
Shortness of breath walking on level ground	0.1	0.1	0.1	0.0	0.4
Mean time to correctly identify matches	0.1	0.2	0.3	0.6	0.2
Heart disease (mother)	0.1	0.2	0.3	-0.5	0.3
Suffer from ‘nerves’	0.1	0.2	0.3	0.3	0.6
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.4	-0.0
Smoking status: Previous	0.1	0.2	0.3	0.5	0.1
Qualifications: nursing, teaching	0.1	0.1	0.2	-0.2	-0.5
Osteoporosis (self-reported)	0.1	0.1	0.2	0.4	-0.1
Average weekly champagne plus white wine intake	0.1	0.2	0.4	-0.1	0.6
Miserableness	0.1	0.2	0.3	-0.3	-0.5
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.3	-0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.5	-0.1
Unable to work because of sickness or disability	0.1	0.1	0.1	0.3	0.3
Impedance of whole body	0.1	0.3	0.4	0.2	0.7
Worry (Nagel 2018)	0.0	0.1	0.1	-0.2	0.3
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	0.3	-0.1
Reaction Time	0.0	0.1	0.2	0.4	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Lupus	0.0	0.0	0.0	0.2	0.2
Neuroticism (2016)	0.0	0.1	0.1	-0.0	0.4
Schizophrenia (2014)	0.0	0.0	0.1	-0.3	-0.0
Blood Red Count	0.0	0.0	0.0	0.1	0.0
Respiratory disease	0.0	0.0	0.0	-0.0	-0.2
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	-0.1	0.1
Hearing difficulty/problems: Yes	0.0	0.0	0.0	-0.2	-0.1
Vitamin and mineral supplements	0.0	0.1	0.1	0.3	-0.2
Impedance of leg (right)	0.0	0.1	0.1	-0.3	0.3
Impedance of leg (left)	0.0	0.1	0.3	-0.1	0.5
Past tobacco smoking	0.0	0.0	0.0	-0.0	0.2
Alcohol usually taken with meals	0.0	0.0	0.1	0.3	0.1
Allergy	0.0	0.0	0.1	0.3	-0.1
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.1	-0.2	-0.3
Peak expiratory flow (PEF)	0.0	0.1	0.2	0.5	-0.0
Age at first live birth	0.0	0.0	0.0	-0.1	0.1
Migraine (self-reported)	0.0	0.0	0.0	0.1	-0.1
Pulse rate, automated reading	0.0	0.1	0.1	-0.3	-0.1
Leg pain on walking	0.0	0.0	0.0	-0.2	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.0	-0.2	-0.0
Asthma (self-reported)	0.0	0.1	0.2	0.4	0.1
Guilty feelings	0.0	0.0	0.0	-0.0	0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.1	0.1	-0.1	0.3
Ever smoked	0.0	0.0	0.0	0.1	-0.0
Number of operations (self-reported)	0.0	0.0	0.0	0.1	0.2
Diastolic blood pressure, automated reading	0.0	0.1	0.2	0.5	0.2

Hub : Genes

TULP1

Models

Trait associations