TWAS hub - GNB2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0390	0.0165	0.00041	-0.001	0.011	0.003	0.012	-0.001	0.8600	9.7e-05	0.0300	6.5e-05	0.570
2	TCGA	Bladder Urothelial Carcinoma	0.0380	0.0250	0.00620	0.025	0.012	0.019	NA	0.013	0.0033	3.2e-02	0.0095	NA	0.026
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0261	0.0158	0.00290	0.007	0.022	0.015	NA	0.011	0.0530	1.3e-03	0.0077	NA	0.020
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1450	0.0740	0.00710	0.005	0.008	0.005	NA	-0.005	0.1500	1.0e-01	0.1600	NA	0.800
5	TCGA	Brain Lower Grade Glioma	0.0178	0.0113	0.00830	0.006	0.013	0.002	NA	0.003	0.0550	1.2e-02	0.1700	NA	0.130

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Blood Red Count	56.9	549.2	1560.2	19.4	25.0	-7.4	11.4	39.5
Pulse rate, automated reading	20.6	66.4	196.0	3.7	-8.3	-14.0	7.2	1.5
Pulse rate	13.4	22.5	66.1	2.4	-4.1	-8.1	4.5	2.0
Hypothyroidism/myxoedema (self-reported)	7.4	14.4	29.4	-3.4	1.8	4.9	-5.4	-2.0
Hypothyroidism (self reported)	7.2	16.6	30.9	-3.9	1.7	5.3	-5.6	-2.4
Blood Platelet Count	5.9	68.0	201.6	-2.9	-10.6	0.0	-4.2	-14.2
Medication: Levothyroxine sodium	5.4	9.2	24.2	-2.2	0.3	3.3	-4.9	-2.4
Stomach or abdominal pain in last month	5.2	6.4	14.2	0.3	3.5	3.8	-2.1	1.2
Blood clot in the leg (DVT)	4.4	5.7	15.5	-1.8	-0.3	2.1	-3.9	-2.3
Diastolic blood pressure, automated reading	4.3	13.5	26.8	2.3	-1.0	-5.0	5.2	3.1
Deep venous thrombosis (DVT) (self-reported)	4.2	5.4	16.3	-1.6	-0.1	2.1	-4.0	-2.0
Medication: Metformin	3.9	5.5	16.1	-4.0	-0.9	0.9	-2.2	-2.2
Age at First Birth	3.8	5.5	10.4	-2.5	-1.3	1.7	-2.5	-3.2
Schizophrenia (2014)	3.5	7.7	22.1	2.0	-1.5	-4.7	2.3	2.2
Supplements: Fish oil (including cod liver oil)	3.2	4.2	11.7	-0.1	-2.0	1.0	-2.0	-3.4
Cholesterol lowering medication	3.1	4.5	12.4	0.2	-2.8	-3.5	1.3	-0.7
Type 2 Diabetes (T2D) (2018)	3.0	5.6	9.4	-3.1	1.6	2.6	-3.0	-0.2
Schizophrenia (2018)	2.9	6.0	17.8	2.3	-1.6	-4.2	1.4	1.6
Crohns Disease (2012)	2.9	4.6	7.5	2.7	0.2	-2.5	1.6	2.5
Diabetes diagnosed by doctor	2.9	4.8	8.7	-2.8	0.6	2.2	-2.9	-1.3
Had other major operations	2.8	3.5	7.7	1.3	2.0	2.8	-1.9	0.4
Supplements: Glucosamine	2.7	3.6	9.3	-0.2	0.7	2.6	-3.0	-1.2
Crohns Disease (2017)	2.6	5.6	15.1	1.7	-1.3	-3.9	2.4	1.7
Rheumatoid Arthritis	2.6	3.5	9.2	-1.4	-1.3	0.5	-3.0	-2.1
Schizophrenia vs Biploar Disorder	2.5	3.3	6.4	1.5	0.5	-2.0	1.9	2.5
Other serious medical condition/disability diagnosed by doctor	2.5	3.2	6.0	-1.1	-1.9	-0.2	-2.4	-2.3
Bipolar Disorder or Schizophrenia	2.4	5.9	17.3	2.3	-1.6	-4.2	1.4	1.6
Diabetes (self-reported)	2.4	3.7	7.0	-2.6	0.4	1.9	-2.6	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	5.8	1.3	1.9	0.1	1.8	2.4
Alzheimer’s Disease (including proxy)	2.3	3.3	8.9	3.0	0.3	1.8	-1.7	-1.1
Irritable Bowel Disease (IBD)	2.3	5.5	19.0	0.5	-2.5	-4.4	1.3	0.5
Fasting Glucose	2.3	2.8	7.2	-2.7	0.2	1.3	-1.9	-1.1
Pulse wave peak to peak time	2.2	2.6	6.6	-0.2	-1.5	0.8	-1.9	-2.6
Pulse wave Arterial Stiffness index	2.1	2.5	5.8	-0.1	1.5	-0.6	2.0	2.4
High blood pressure (siblings)	2.1	3.1	5.5	-1.9	-1.6	0.5	-1.9	-2.3
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	13.3	-3.6	-1.0	1.2	-0.3	-2.5
Average weekly champagne plus white wine intake	2.0	2.8	6.2	-0.6	2.5	2.5	0.3	1.1
Relative age voice broke	1.9	2.9	6.0	-2.4	-2.0	-1.8	-0.5	-0.9
Smoking status: Previous	1.9	2.8	4.8	-2.0	0.7	2.0	-2.2	-1.1
Ulcerative Colitis (UC)	1.8	3.4	7.6	-1.0	-2.6	-2.8	-0.6	-1.1
Breastfed as a baby	1.8	2.2	4.5	2.1	1.6	1.7	0.6	0.8
Number of operations (self-reported)	1.8	2.7	9.0	0.1	1.5	1.1	-3.0	1.1
Neuroticism (2016)	1.7	2.5	7.7	-2.8	-1.4	-1.7	-0.1	-0.3
Ever had hysterectomy (womb removed)	1.7	1.9	7.8	-0.3	-0.8	0.3	-2.8	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	7.3	0.1	-2.0	-2.7	-0.4	-0.2
Lung cancer (father)	1.7	2.0	4.8	-0.0	-2.2	-1.3	0.4	-1.8
Age at first live birth	1.7	3.0	9.2	-0.8	1.6	3.0	-1.6	-0.5
Medication: Atorvastatin	1.7	2.1	4.1	0.8	-1.5	-2.0	1.8	-0.4
Alzheimer’s Disease (in mother)	1.6	1.8	6.2	2.5	0.9	1.5	-0.3	-0.2
Reaction Time	1.6	3.0	10.8	0.3	-0.9	-3.3	-0.5	1.7
Fed-up feelings	1.6	3.0	7.0	1.7	-2.1	-2.7	-0.6	-0.4
Age when periods started (menarche)	1.6	3.9	15.1	-3.9	-1.2	-0.1	-0.5	-1.6
Alcohol usually taken with meals	1.6	2.6	5.6	1.5	2.4	1.6	-0.1	1.6
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	3.8	1.4	0.5	1.9	-1.9	-0.9
Hair/balding pattern: Pattern 3	1.6	2.4	7.2	1.2	1.6	2.7	-0.8	-0.1
Glaucoma (self-reported)	1.6	1.8	5.0	2.2	0.7	-0.7	0.2	1.7
Handedness (chirality/laterality): Left-handed	1.6	1.9	4.5	0.2	-2.1	-1.9	0.5	-1.1
Supplements: Zinc	1.5	1.6	3.3	-0.9	1.8	1.1	-0.5	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	3.2	1.2	1.8	1.8	-0.2	0.8
Chronic bronchitis/emphysema (mother)	1.5	1.8	4.4	-0.0	-0.1	-2.1	1.4	1.5
Medication: Lisinopril	1.5	1.9	5.5	-2.3	1.3	0.9	0.7	1.0
HbA1C	1.4	1.6	3.1	1.2	1.4	0.3	-1.1	1.8
Medication: Lansoprazole	1.4	1.6	5.5	2.4	-0.5	-1.3	-0.4	0.5
Prospective memory result	1.4	1.8	5.3	1.2	-1.3	-2.3	0.6	0.2
Mean time to correctly identify matches	1.4	2.7	9.7	0.7	-1.5	-3.1	-0.3	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	4.5	0.7	-1.6	-2.1	0.9	-0.3
Mineral and other dietary supplements	1.4	1.9	3.7	-0.9	0.6	-1.5	1.6	1.9
Ever taken oral contraceptive pill	1.4	1.6	4.2	-2.1	0.4	1.3	-1.3	-0.4
Illnesses of siblings	1.3	1.9	3.7	1.9	1.6	0.6	0.8	1.5
Leg fat percentage (left)	1.3	4.6	15.0	1.4	-1.6	-3.9	1.4	1.3
Hearing difficulty/problems: Yes	1.2	1.8	2.7	-1.6	-1.3	0.1	-1.4	-1.7
Chronic bronchitis/emphysema (father)	1.2	1.5	4.5	-0.9	-1.0	-2.1	0.8	0.6
Hair/balding pattern: Pattern 2	1.2	1.5	5.3	-2.3	-0.4	-0.4	1.5	-0.1
Allergy	1.2	2.7	5.7	-0.3	-1.9	-1.7	2.4	-1.1
Falls in the last year	1.2	1.7	2.1	1.4	-1.5	-1.3	-1.4	-0.7
Leg fat percentage (right)	1.2	4.4	13.0	1.6	-1.1	-3.6	1.5	1.8
Emphysema/chronic bronchitis	1.2	1.3	4.9	-2.2	0.1	0.9	-0.6	-0.7
Medication: Omeprazole	1.2	1.4	3.3	-0.1	1.6	1.8	-0.9	0.7
Chest pain or discomfort	1.2	1.8	4.6	2.1	1.1	-0.3	0.2	1.7
Leg pain on walking	1.2	1.6	4.3	1.5	0.6	0.9	-2.1	0.0
Friendships satisfaction	1.2	1.5	3.8	1.6	-0.8	-2.0	-0.2	0.7
Osteoarthritis (self-reported)	1.2	1.6	4.2	1.5	-0.0	1.0	-2.1	-0.7
Hearing aid user	1.2	1.3	3.3	1.8	-0.7	-1.5	-0.8	0.3
Ever smoked	1.2	2.1	6.5	-2.5	0.0	1.0	-1.3	-1.1
Breast Cancer	1.1	2.6	5.5	-1.1	2.3	1.0	-1.0	2.1
Blood Eosinophil Count	1.1	8.6	22.6	2.8	-1.4	-4.8	2.2	2.5
Hair Pigment	1.1	32.5	92.4	-9.6	1.2	5.9	-4.2	-4.0
Hand grip strength (right)	1.1	2.9	6.6	-1.5	-0.3	-2.0	2.6	1.3
Townsend deprivation index at recruitment	1.1	1.5	3.0	0.9	0.6	-1.2	1.4	1.7
Average weekly fortified wine intake	1.1	1.3	3.1	0.4	1.6	1.8	-0.1	0.6
Had menopause	1.1	1.4	3.5	0.8	-1.9	-1.1	-0.4	-1.2
Overall health rating	1.1	2.3	4.0	-0.1	-2.0	-1.8	-1.8	-1.0
Commuting to job workplace: Car/motor vehicle	1.1	1.2	4.0	2.0	0.6	-0.1	0.9	0.9
Mood swings	1.1	2.0	4.2	-1.9	-0.8	0.4	-2.0	-1.4
Loneliness, isolation	1.1	1.5	4.0	1.0	-1.5	-2.0	-0.7	-0.1
Alzheimer’s Disease (in father)	1.0	1.1	2.5	0.5	0.5	1.4	-1.6	-0.6
Major Depression (MDD)	1.0	1.2	1.8	-1.3	-1.1	-1.2	-1.2	-0.3
Relative age of first facial hair	1.0	2.0	4.6	-1.9	-0.2	0.8	-2.1	-0.9
Serious illness, injury or assault to yourself	1.0	1.2	2.5	1.0	0.3	-1.1	-1.1	1.6
Past tobacco smoking	1.0	1.9	5.7	2.4	-0.2	-0.8	1.5	0.8
Medication: Simvastatin	1.0	1.5	2.6	-1.3	-1.6	-0.7	-0.3	-1.5
Happiness	1.0	1.2	4.0	2.0	0.5	-0.6	0.3	1.2
Pulse wave reflection index	1.0	1.2	2.7	-0.5	1.6	1.0	-0.9	1.1
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	7.0	2.6	0.4	-0.1	-0.5	0.8
Wheeze or whistling in the chest in last year	1.0	1.7	4.6	0.2	0.6	-1.6	1.0	2.2
Qualifications: College or University degree	1.0	3.0	7.3	-1.0	2.2	2.7	-1.1	0.6
Medication: Aspirin	1.0	1.4	2.3	-1.4	0.2	1.2	-1.5	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.3	0.3	-0.1	1.5	-1.1	-1.5
Ever had bowel cancer screening	1.0	1.1	2.4	-0.5	-1.1	-1.5	-1.3	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.0	0.1	1.4	1.4	-1.1	0.6
Medication: Gliclazide	1.0	1.1	3.4	-1.3	-0.4	0.1	-1.8	-0.7
Smoking status: Current	1.0	1.6	5.0	0.6	-1.0	-2.2	1.2	0.6
High cholesterol (Self-reported)	1.0	1.7	3.8	1.9	-0.9	-1.6	1.1	0.3
Medication: Paracetamol	1.0	1.5	3.1	1.5	1.3	-0.2	0.6	1.8
Average weekly beer plus cider intake	1.0	1.4	5.3	-0.5	-0.2	-1.1	2.3	0.5
Commuting to job workplace: Cycle	1.0	1.2	2.1	-1.1	-1.1	-0.1	-1.5	-1.3
Mean Putamen Volume	0.9	1.0	1.7	-0.7	1.3	0.2	1.1	1.3
Diabetes (father)	0.9	1.1	4.1	-0.8	0.1	0.7	-2.0	-0.5
Hayfever, allergic rhinitis or eczema	0.9	2.0	2.8	1.5	1.7	0.8	-1.3	1.7
Medication: Atenolol	0.9	1.2	2.8	-1.7	-0.2	1.1	-0.3	-1.3
Time employed in main current job	0.9	1.1	2.3	0.7	-0.1	-1.5	1.2	1.0
Medication: Amlodipine	0.9	1.3	3.0	-0.0	-1.1	-1.7	1.6	-0.1
Medication: Blood pressure	0.9	1.6	5.9	-2.4	0.7	0.5	1.2	0.2
Family relationship satisfaction	0.9	1.1	2.6	1.1	-0.2	-1.6	0.6	1.0
Osteoporosis (self-reported)	0.9	1.1	2.7	-0.4	-1.5	-1.6	0.2	-0.6
Miserableness	0.9	1.6	3.4	-0.5	-1.7	-1.9	-1.0	-0.6
Eye problems/disorders: Glaucoma	0.9	1.1	2.5	1.6	0.3	-0.9	0.1	1.4
Age started oral contraceptive pill	0.9	1.1	2.4	-0.5	-1.5	-0.9	1.1	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.8	-0.1	1.4	1.7	-0.8	0.4
Depressed Affect (Nagel 2018)	0.8	1.6	2.7	-0.7	-1.6	-1.2	-1.6	-0.9
Depression (Nagel 2018)	0.8	1.3	4.5	0.1	-1.0	-2.1	-0.1	0.8
Ulcerative Colitis	0.8	1.2	3.6	0.2	-1.1	-1.9	-1.1	0.2
BMI	0.8	4.6	10.5	2.8	1.4	-1.7	0.3	3.2
Waist Hip Ratio (WHR)	0.8	3.5	9.4	-3.1	0.6	2.3	0.2	-1.5
Systolic Blood Pressure	0.8	4.0	11.1	-1.8	0.5	3.3	-0.6	-2.3
Severe depression (siblings)	0.8	0.8	1.6	0.4	0.2	-1.0	1.2	1.2
Current tobacco smoking	0.8	1.4	4.0	0.7	-0.8	-2.0	1.1	0.7
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.8	0.8	-0.7	-0.1	-1.7	-0.8
Sitting height	0.8	5.8	16.7	-1.2	3.0	4.1	-1.4	0.3
Heart attack	0.8	1.0	3.0	-0.4	1.3	1.7	-0.3	0.1
Peak expiratory flow (PEF)	0.8	1.8	4.5	-0.9	0.9	2.1	-1.5	-0.6
Medication: Ventolin 100micrograms inhaler	0.8	1.1	5.2	-2.3	-0.2	-0.1	-0.2	-0.3
Eye problems/disorders: Cataract	0.8	0.9	3.9	-2.0	0.6	0.2	0.4	0.5
Medication for cholesterol	0.8	1.2	3.4	0.1	1.5	1.8	-0.4	0.4
Guilty feelings	0.8	1.2	3.1	0.7	-0.2	-1.8	0.3	1.5
Financial situation satisfaction	0.8	1.0	2.2	-0.2	-1.5	-0.8	0.6	-1.4
Risk taking	0.8	1.2	2.4	-1.1	0.2	-1.5	-0.4	1.6
Alcohol drinker status: Previous	0.8	1.0	2.3	-0.4	-1.5	-0.6	-0.5	-1.3
Ovarian Cancer	0.7	0.9	3.1	-0.8	0.7	1.8	-0.3	-0.4
Prostate Cancer	0.7	0.9	2.0	1.3	-0.5	-1.4	0.7	0.5
Primary Biliary Cirrhosis	0.7	1.0	2.6	-1.6	-0.0	1.1	-0.3	-1.0
Blood White Count	0.7	5.4	13.2	1.6	0.6	-3.2	0.6	3.6
Heel T-Score	0.7	5.9	18.9	-0.3	2.3	1.1	-4.3	2.0
Smoking Status	0.7	1.7	5.2	-0.7	-1.6	-2.3	0.3	-0.3
Hand grip strength (left)	0.7	2.0	5.3	-1.9	-0.4	-0.8	2.3	0.1
Systolic blood pressure, automated reading	0.7	2.2	7.5	-0.0	-1.3	1.2	-0.4	-2.7
Impedance of leg (left)	0.7	3.3	7.5	-1.2	-1.7	-2.1	2.7	-0.3
Qualifications: A levels/AS levels or equivalent	0.7	1.6	5.6	-0.5	0.9	2.4	-0.6	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.4	-1.0	1.0	1.6	-0.5	-0.0
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.0	0.8	-0.2	0.6	-1.7	-0.8
Forced vital capacity (FVC), Best measure	0.7	2.4	10.6	-3.3	-0.2	0.7	0.1	-0.9
Neck or shoulder pain in last month	0.7	1.0	3.2	0.9	-0.7	-0.4	-1.8	-0.5
Suffer from ‘nerves’	0.7	1.1	3.6	0.9	-0.8	-1.9	0.0	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.0	0.1	-1.3	-1.4	0.2	-0.6
Number of self-reported non-cancer illnesses	0.7	1.2	3.7	-0.3	-0.3	0.9	-1.9	-1.1
Mother’s age at death	0.7	0.9	2.5	0.5	1.0	1.6	-0.7	0.0
Alcohol drinker status: Never	0.7	0.8	2.8	0.7	0.8	1.7	0.3	-0.3
Lupus	0.6	0.8	2.7	0.6	0.7	0.6	-1.6	0.5
Allergy or Eczema	0.6	1.6	2.3	1.5	1.4	0.8	-1.3	1.2
Lung FVC	0.6	2.8	4.5	-2.0	-2.0	-2.1	1.1	-0.7
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.2	-0.4	-1.1	-0.4	-1.1	-1.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.1	-1.0	-0.5	0.6	-0.7	-1.1
Angina	0.6	0.8	2.2	0.4	1.3	1.5	-0.1	0.3
Taking other prescription medications	0.6	0.9	2.9	-0.3	0.7	0.9	-1.7	0.3
Number of incorrect matches in round	0.6	0.9	3.7	-0.3	-0.7	-1.9	0.2	0.6
Mouth/teeth dental problems: Dentures	0.6	1.0	2.8	1.7	-0.2	0.9	-0.5	-1.1
Medication: Cholesterol lowering	0.6	0.9	2.7	-1.6	-0.7	0.1	-0.1	-1.2
Standing height	0.6	6.1	13.1	-3.1	2.7	3.6	0.5	0.3
Exposure to tobacco smoke at home	0.6	0.7	1.5	0.7	1.1	1.2	-0.6	0.4
Tense / ‘highly strung’	0.6	1.0	2.2	1.5	0.4	-1.0	0.3	1.3
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.8	-0.6	-0.8	-0.4	-1.4	-0.8
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.0	-1.4	0.6	1.4	-0.6	-0.4
Medication: Paracetamol	0.6	0.9	2.4	0.7	1.3	0.2	0.4	1.5
Body fat percentage	0.6	2.3	5.2	1.5	-0.2	-2.3	1.0	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.3	-1.1	-1.1	-0.9	-0.3	-0.6
Health satisfaction	0.6	0.7	3.2	-0.2	-0.4	-0.0	-1.8	-0.5
Medication for pain relief, constipation, heartburn	0.6	1.1	2.7	1.0	-1.2	-1.6	0.5	-0.1
Angina (self-reported)	0.6	0.8	2.3	0.5	1.1	1.5	-0.2	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.8	-0.3	-1.3	-0.5	-0.1	-1.4
Knee pain experienced in last month	0.6	0.9	1.8	0.6	0.6	1.3	-1.3	-0.5
Illnesses of siblings: Diabetes	0.6	0.7	3.1	-0.0	-0.4	-0.4	-1.7	0.1
Average weekly red wine intake	0.6	0.9	1.5	-1.2	-0.6	0.5	-0.9	-1.1
Long-standing illness, disability or infirmity	0.6	0.9	3.1	0.2	0.1	0.9	-1.8	-0.5
Medication: Aspirin	0.6	0.8	2.0	-0.9	-0.0	0.7	-1.4	-0.8
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.3	1.5	-0.0	0.7	-1.0	-0.3
Fractured/broken bones in last 5 years	0.6	0.8	1.7	1.3	-0.9	-1.0	-0.7	-0.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.5	-0.4	1.2	1.6	-0.2	0.1
Heart disease (siblings)	0.6	0.7	2.0	-0.9	-0.3	-0.8	1.4	0.2
Cardiovascular Disease	0.5	1.7	5.1	-0.4	-0.1	-1.5	2.2	1.1
Lung FEV1/FVC ratio	0.5	2.6	5.3	2.3	-1.5	0.3	-1.1	-2.1
Sensitivity / hurt feelings	0.5	0.9	2.4	-0.5	0.2	1.2	-1.6	-0.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.2	-0.1	-1.0	-1.5	-0.7	0.2
Diabetes (mother)	0.5	0.6	2.0	-0.4	0.3	0.8	-1.4	-0.4
Qualifications: CSEs or equivalent	0.5	0.7	1.3	-0.8	-1.1	-1.1	-0.1	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.8	0.7	-0.1	-1.4	-0.3	1.1
Qualifications: None of the above	0.5	1.1	1.7	1.3	-1.3	-1.1	0.5	-0.7
Fluid intelligence score	0.5	1.1	2.3	-0.4	-1.5	-1.5	0.8	-0.5
Alcohol intake versus 10 years previously	0.5	0.7	1.6	0.1	-1.0	-0.1	-1.0	-1.3
Worrier / anxious feelings	0.5	1.0	3.4	0.3	-0.7	-1.9	-0.3	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.3	-0.3	-0.5	-0.5	-1.8	-0.2
Illnesses of mother	0.5	0.6	1.4	0.3	1.2	0.4	-0.3	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	4.0	-2.0	-0.1	1.4	-0.6	-1.3
Impedance of arm (left)	0.5	2.2	3.0	-1.6	1.7	1.5	1.4	0.9
Length of working week for main job	0.5	0.6	1.4	-1.2	-0.8	-0.3	-0.4	-0.7
Number of children fathered	0.5	0.6	2.0	0.6	0.7	1.4	-0.4	-0.2
Migraine (self-reported)	0.5	0.7	2.8	1.7	0.4	0.3	-0.4	0.4
Medication: Ibuprofen	0.5	0.6	1.3	-0.0	1.2	1.2	0.1	0.6
Leg fat mass (right)	0.5	2.0	5.2	1.4	-0.3	-2.3	0.6	1.5
Hypertension (Self-reported)	0.5	1.5	4.6	-1.2	-0.0	-1.0	2.1	0.7
Illnesses of father: Heart disease	0.5	0.7	2.0	1.4	0.4	-0.1	1.0	0.7
Qualifications: nursing, teaching	0.5	0.7	2.0	-1.4	0.6	1.1	0.0	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.6	0.6	0.8	-0.2	1.3	1.3
Back pain experienced in last month	0.5	0.8	1.8	1.4	-0.1	-0.5	-1.3	0.2
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.0	-0.1	0.4	1.4	-0.2	-0.8
Illnesses of father: High blood pressure	0.5	0.6	2.3	-1.5	-0.6	-0.5	-0.1	-0.3
Leg fat mass (left)	0.5	1.9	5.8	1.2	-0.6	-2.4	0.6	1.2
Bipolar Disorder (2018)	0.4	0.7	1.9	0.8	-0.5	-1.4	0.5	0.6
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.6	-1.4	0.6	1.6	0.7	-0.7
HDL Cholesterol	0.4	0.6	3.0	1.7	0.0	0.0	0.0	0.0
Height	0.4	8.1	22.2	-3.2	2.5	4.7	1.1	-0.9
Neuroticism	0.4	0.9	3.1	0.4	-1.0	-1.8	-0.5	0.3
Medication for hormone replacement therapy	0.4	0.5	1.1	-1.0	0.6	0.7	-0.7	0.3
Impedance of leg (right)	0.4	2.1	6.7	-1.0	-0.6	-1.5	2.6	0.5
Leg fat-free mass (left)	0.4	2.0	5.1	0.0	2.2	1.5	-0.6	1.5
Trunk fat percentage	0.4	1.5	2.7	1.2	0.2	-1.5	0.9	1.6
High blood pressure	0.4	1.1	3.6	-1.0	-0.0	-0.7	1.9	0.4
Body mass index (BMI)	0.4	1.7	3.5	1.8	-0.3	-1.9	-0.3	1.1
Leg predicted mass (left)	0.4	2.1	5.1	-0.1	2.3	1.5	-0.7	1.5
Forced vital capacity (FVC)	0.4	1.5	7.5	-2.7	-0.1	0.2	0.2	-0.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.1	0.5	-0.7	-0.3	-1.1	-0.6
Mouth/teeth dental problems	0.4	0.6	3.0	-1.7	-0.0	0.0	-0.2	0.1
Medication: Ramipril	0.4	0.5	0.8	-0.8	-0.9	-0.5	-0.5	-0.8
Neuroticism score	0.4	0.9	2.2	0.1	-1.1	-1.5	-0.9	-0.1
Impedance of arm (right)	0.4	2.0	4.0	-0.9	2.0	1.8	1.0	1.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	3.5	-1.9	0.0	1.2	-0.9	-1.0
Depression (self-reported)	0.4	0.5	0.9	1.0	-0.3	-0.8	-0.8	0.2
Loud music exposure frequency	0.4	0.4	1.0	-1.0	0.6	0.1	0.3	0.8
Comparative body size at age 10	0.4	1.0	2.7	0.5	-1.1	-0.5	-1.6	-0.9
Worry too long after embarrassment	0.4	0.7	1.7	0.8	-0.1	-1.3	0.6	1.0
Shortness of breath walking on level ground	0.4	0.5	1.1	0.1	-1.0	-1.0	-0.4	-0.5
Whole body fat mass	0.4	1.5	3.0	1.2	0.3	-1.6	0.6	1.7
Comparative height size at age 10	0.4	2.1	8.0	-0.6	1.3	2.8	-0.3	-0.7
Number of full sisters	0.4	0.5	1.8	-1.3	0.4	0.6	-0.2	-0.1
Had major operations	0.4	0.5	1.1	0.3	0.5	-0.5	-1.0	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.2	0.2	-1.5	-0.4	-0.3	-1.4
Ever depressed for a whole week	0.4	0.5	1.0	-0.7	0.3	0.8	-1.0	-0.4
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.8	1.3	0.1	0.7	-1.7	-0.4
Supplements: Calcium	0.4	0.5	0.8	-0.3	-0.9	-0.5	-0.9	-0.7
Worry (Nagel 2018)	0.3	0.6	1.4	1.2	0.1	-0.9	0.2	0.9
Verbal and Numeric Reasoning (VNR)	0.3	0.6	0.9	-1.0	0.7	0.9	1.0	0.2
Medication: Co-codamol	0.3	0.3	0.6	0.6	0.7	0.3	-0.0	0.8
Maternal smoking around birth	0.3	0.5	1.2	-0.6	1.1	0.5	-0.3	0.7
High blood pressure (mother)	0.3	0.4	0.9	-0.9	-0.7	-0.2	-0.2	-0.7
Financial difficulties in last 2 years	0.3	0.4	0.8	0.4	0.9	0.5	0.5	0.8
Pain all over the body in last month	0.3	0.4	1.2	0.1	-0.7	-1.1	-0.2	0.1
Arm fat percentage (right)	0.3	1.3	2.8	1.7	0.1	-1.5	0.1	1.3
Number of live births	0.3	0.4	1.0	0.0	-1.0	-0.7	-0.1	-0.6
Noisy workplace	0.3	0.4	0.9	0.1	0.9	0.7	0.4	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.6	0.3	-0.4	-0.3	-1.3	-0.2
Hair/balding pattern: Pattern 4	0.3	0.7	1.7	1.3	0.4	-0.5	0.4	1.1
Birth weight of first child	0.3	0.6	1.4	-0.5	-1.2	-0.5	-0.3	-1.0
Headache pain in last month	0.3	0.5	1.4	0.1	-0.4	0.5	-1.2	-0.8
Birth weight	0.3	0.7	2.6	-1.6	-0.4	-0.5	0.7	-0.0
Number of full brothers	0.3	0.4	0.9	-0.7	-0.6	0.0	-0.6	-1.0
Eye problems/disorders: None of the above	0.3	0.3	0.8	0.9	-0.2	-0.4	0.8	0.2
Medication: Seretide 50 evohaler	0.3	0.3	0.8	0.3	0.2	-0.7	0.5	0.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.6	-0.7	-0.8	-0.4	0.7	-0.6
Leg fat-free mass (right)	0.3	1.5	3.2	-0.3	1.8	1.7	-0.8	0.8
Arm fat percentage (left)	0.3	1.3	2.3	1.4	0.2	-1.5	0.3	1.4
Breast cancer (self-reported)	0.3	0.3	0.6	0.7	-0.8	-0.5	0.2	-0.6
Illnesses of father: None of the above (group 1)	0.3	0.3	1.6	1.3	0.1	0.3	-0.2	-0.1
Leg predicted mass (right)	0.3	1.5	3.5	-0.3	1.9	1.7	-0.8	0.9
Myopia	0.3	0.4	1.0	-1.0	-0.1	0.1	-1.0	0.0
Basal cell carcinoma (self-reported)	0.3	0.4	1.8	-0.1	0.2	0.3	1.3	0.0
Impedance of whole body	0.3	1.5	4.9	-1.4	0.4	-0.1	2.2	0.7
Neuroticism (Nagel 2018)	0.2	0.4	0.9	-0.6	-0.4	-0.9	-0.8	0.4
Respiratory disease	0.2	0.4	1.7	-1.3	-0.3	-0.2	-0.0	-0.2
Vitamin and mineral supplements	0.2	0.2	0.4	-0.0	0.7	0.2	0.5	0.6
Pack years adult smoking proportion	0.2	0.3	0.6	-0.4	0.6	-0.3	0.3	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.0	0.2	0.1	-0.4	-1.4	0.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.6	0.6	0.2	-0.3	0.7
Multivitamins +/- minerals	0.2	0.3	0.9	-0.1	-0.6	0.3	-0.2	-1.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	0.6	0.7	0.4	0.2	0.3
Trunk fat mass	0.2	0.9	2.3	0.7	0.5	-1.1	0.6	1.5
Hip circumference	0.2	0.7	1.6	1.1	0.8	-0.3	-0.2	1.3
Father’s age at death	0.2	0.3	1.1	1.0	0.3	0.4	0.1	-0.0
Asthma	0.2	0.3	0.6	-0.3	0.8	0.3	0.3	0.8
Arm fat mass (right)	0.2	0.8	1.5	1.2	0.2	-1.1	0.1	1.1
Exposure to tobacco smoke outside home	0.2	0.3	1.0	-1.0	0.1	-0.2	0.3	0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.7	0.4	-0.0	-0.8	0.3	0.5
Medication: Allopurinol	0.2	0.3	0.4	-0.7	-0.5	-0.2	0.5	-0.6
Alcohol intake frequency.	0.2	0.4	0.8	0.7	-0.9	-0.2	-0.5	-0.7
Supplements: Vitamin C	0.2	0.2	0.7	0.6	-0.0	0.0	-0.8	-0.1
Whole body fat-free mass	0.2	0.9	2.0	-0.4	1.4	1.3	-0.7	0.6
Whole body water mass	0.2	0.9	1.9	-0.4	1.4	1.2	-0.8	0.6
Arm fat mass (left)	0.2	0.9	1.9	1.0	0.0	-1.4	0.2	1.1
Commuting to job workplace: Public transport	0.2	0.3	0.6	0.5	0.7	0.8	-0.1	0.3
Medication: Blood pressure	0.2	0.4	1.3	0.3	-0.5	-1.1	0.4	0.4
Irritability	0.2	0.3	0.7	-0.4	0.1	-0.4	-0.8	0.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	0.1	-0.5	-0.7	0.5	-0.0
Unable to work because of sickness or disability	0.2	0.3	0.7	0.4	-0.7	-0.8	-0.6	-0.1
Pain experienced in last month	0.2	0.4	0.9	-0.8	0.5	0.2	0.9	0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	0.7	0.0	0.0	0.0	0.0
Tanning	0.1	1.3	3.0	1.7	1.4	1.0	0.2	0.8
Number of treatments/medications taken	0.1	0.2	0.6	0.8	-0.2	-0.2	-0.4	-0.1
Average weekly spirits intake	0.1	0.2	0.5	0.2	-0.6	-0.0	0.1	-0.7
Nervous feelings	0.1	0.3	0.4	0.1	0.6	0.3	-0.6	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.6	-0.5	0.1	-0.5	-0.8	0.7
Weight	0.1	0.5	1.5	0.4	0.9	-0.2	-0.0	1.2
Trunk fat-free mass	0.1	0.7	1.7	-0.6	1.0	1.3	-0.8	0.1
Trunk predicted mass	0.1	0.7	1.6	-0.6	1.0	1.3	-0.8	0.1
Gout (self-reported)	0.1	0.2	0.7	0.2	-0.3	-0.4	0.8	0.0
Heart disease (mother)	0.1	0.1	0.4	-0.6	0.1	0.2	0.4	-0.1
Age at last live birth	0.1	0.1	0.3	-0.2	-0.3	0.1	0.5	-0.5
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.4	0.0	0.5	-0.4	-0.3
Asthma (self-reported)	0.1	0.2	0.5	-0.4	0.6	0.1	0.3	0.7
Wears glasses or contact lenses	0.1	0.2	0.3	0.6	-0.1	-0.4	0.3	0.5
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.6	-0.1	-0.0	0.6	-0.1
Basal metabolic rate	0.1	0.6	1.3	-0.2	1.2	0.8	-0.5	0.7
Pack years of smoking	0.1	0.1	0.3	-0.6	0.3	-0.1	0.0	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	-0.1	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.1	0.4	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.1	0.3	0.5	0.0	0.0	0.0	0.0
Chronotype (morning person)	0.0	0.1	0.3	-0.5	-0.1	0.0	-0.5	-0.2
Waist circumference	0.0	0.1	0.3	0.5	0.2	0.2	-0.4	0.1
Hearing difficulty/problems with background noise	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.0	0.1
Arm fat-free mass (right)	0.0	0.1	0.2	-0.1	0.4	-0.1	-0.1	0.5
Arm predicted mass (right)	0.0	0.1	0.4	-0.1	0.5	-0.1	0.0	0.6
Arm fat-free mass (left)	0.0	0.1	0.2	0.1	0.2	-0.2	-0.3	0.4
Arm predicted mass (left)	0.0	0.2	0.5	0.4	0.6	0.0	-0.1	0.7

Hub : Genes

GNB2

Models

Trait associations