Hub : Genes

GNB2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 YFS Blood 0.0390 0.0165 0.00041 -0.001 0.011 0.003 0.012 -0.001 0.8600 9.7e-05 0.0300 6.5e-05 0.570
2 TCGA Bladder Urothelial Carcinoma 0.0380 0.0250 0.00620 0.025 0.012 0.019 NA 0.013 0.0033 3.2e-02 0.0095 NA 0.026
3 TCGA Head and Neck Squamous Cell Carcinoma 0.0261 0.0158 0.00290 0.007 0.022 0.015 NA 0.011 0.0530 1.3e-03 0.0077 NA 0.020
4 TCGA Kidney Renal Papillary Cell Carcinoma 0.1450 0.0740 0.00710 0.005 0.008 0.005 NA -0.005 0.1500 1.0e-01 0.1600 NA 0.800
5 TCGA Brain Lower Grade Glioma 0.0178 0.0113 0.00830 0.006 0.013 0.002 NA 0.003 0.0550 1.2e-02 0.1700 NA 0.130

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.4 0.7 1.9 0.8 -0.5 -1.4 0.5 0.6
Bipolar Disorder or Schizophrenia 2.4 5.9 17.3 2.3 -1.6 -4.2 1.4 1.6
Depressed Affect (Nagel 2018) 0.8 1.6 2.7 -0.7 -1.6 -1.2 -1.6 -0.9
Depression (Nagel 2018) 0.8 1.3 4.5 0.1 -1.0 -2.1 -0.1 0.8
Intelligence (Savage-Jansen 2018) 0.4 1.2 2.6 -1.4 0.6 1.6 0.7 -0.7
Neuroticism (Nagel 2018) 0.2 0.4 0.9 -0.6 -0.4 -0.9 -0.8 0.4
Schizophrenia (2018) 2.9 6.0 17.8 2.3 -1.6 -4.2 1.4 1.6
Schizophrenia vs Biploar Disorder 2.5 3.3 6.4 1.5 0.5 -2.0 1.9 2.5
Worry (Nagel 2018) 0.3 0.6 1.4 1.2 0.1 -0.9 0.2 0.9
Alzheimer’s Disease (in mother) 1.6 1.8 6.2 2.5 0.9 1.5 -0.3 -0.2
Alzheimer’s Disease (in father) 1.0 1.1 2.5 0.5 0.5 1.4 -1.6 -0.6
Alzheimer’s Disease (including proxy) 2.3 3.3 8.9 3.0 0.3 1.8 -1.7 -1.1
Crohns Disease (2017) 2.6 5.6 15.1 1.7 -1.3 -3.9 2.4 1.7
Irritable Bowel Disease (IBD) 2.3 5.5 19.0 0.5 -2.5 -4.4 1.3 0.5
Ulcerative Colitis (UC) 1.8 3.4 7.6 -1.0 -2.6 -2.8 -0.6 -1.1
Major Depression (MDD) 1.0 1.2 1.8 -1.3 -1.1 -1.2 -1.2 -0.3
Reaction Time 1.6 3.0 10.8 0.3 -0.9 -3.3 -0.5 1.7
Verbal and Numeric Reasoning (VNR) 0.3 0.6 0.9 -1.0 0.7 0.9 1.0 0.2
Breast Cancer 1.1 2.6 5.5 -1.1 2.3 1.0 -1.0 2.1
Ovarian Cancer 0.7 0.9 3.1 -0.8 0.7 1.8 -0.3 -0.4
Prostate Cancer 0.7 0.9 2.0 1.3 -0.5 -1.4 0.7 0.5
Age at First Birth 3.8 5.5 10.4 -2.5 -1.3 1.7 -2.5 -3.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.0 0.0 0.0 -0.1 0.0 0.0 0.0 0.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 2.9 4.6 7.5 2.7 0.2 -2.5 1.6 2.5
Mean Putamen Volume 0.9 1.0 1.7 -0.7 1.3 0.2 1.1 1.3
Fasting Glucose 2.3 2.8 7.2 -2.7 0.2 1.3 -1.9 -1.1
HbA1C 1.4 1.6 3.1 1.2 1.4 0.3 -1.1 1.8
HDL Cholesterol 0.4 0.6 3.0 1.7 0.0 0.0 0.0 0.0
LDL Cholesterol 0.0 0.0 0.1 0.4 0.0 0.0 0.0 0.0
Lupus 0.6 0.8 2.7 0.6 0.7 0.6 -1.6 0.5
Neuroticism (2016) 1.7 2.5 7.7 -2.8 -1.4 -1.7 -0.1 -0.3
Primary Biliary Cirrhosis 0.7 1.0 2.6 -1.6 -0.0 1.1 -0.3 -1.0
Rheumatoid Arthritis 2.6 3.5 9.2 -1.4 -1.3 0.5 -3.0 -2.1
Schizophrenia (2014) 3.5 7.7 22.1 2.0 -1.5 -4.7 2.3 2.2
Triglycerides 0.0 0.1 0.3 0.5 0.0 0.0 0.0 0.0
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.5 0.7 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.8 1.2 3.6 0.2 -1.1 -1.9 -1.1 0.2
Blood Eosinophil Count 1.1 8.6 22.6 2.8 -1.4 -4.8 2.2 2.5
Blood Platelet Count 5.9 68.0 201.6 -2.9 -10.6 0.0 -4.2 -14.2
Blood Red Count 56.9 549.2 1560.2 19.4 25.0 -7.4 11.4 39.5
Blood White Count 0.7 5.4 13.2 1.6 0.6 -3.2 0.6 3.6
Heel T-Score 0.7 5.9 18.9 -0.3 2.3 1.1 -4.3 2.0
BMI 0.8 4.6 10.5 2.8 1.4 -1.7 0.3 3.2
Height 0.4 8.1 22.2 -3.2 2.5 4.7 1.1 -0.9
Waist Hip Ratio (WHR) 0.8 3.5 9.4 -3.1 0.6 2.3 0.2 -1.5
Systolic Blood Pressure 0.8 4.0 11.1 -1.8 0.5 3.3 -0.6 -2.3
Smoking Status 0.7 1.7 5.2 -0.7 -1.6 -2.3 0.3 -0.3
Allergy or Eczema 0.6 1.6 2.3 1.5 1.4 0.8 -1.3 1.2
Cardiovascular Disease 0.5 1.7 5.1 -0.4 -0.1 -1.5 2.2 1.1
Hypothyroidism (self reported) 7.2 16.6 30.9 -3.9 1.7 5.3 -5.6 -2.4
Respiratory disease 0.2 0.4 1.7 -1.3 -0.3 -0.2 -0.0 -0.2
Type 2 Diabetes (T2D) (2018) 3.0 5.6 9.4 -3.1 1.6 2.6 -3.0 -0.2
Lung FEV1/FVC ratio 0.5 2.6 5.3 2.3 -1.5 0.3 -1.1 -2.1
Lung FVC 0.6 2.8 4.5 -2.0 -2.0 -2.1 1.1 -0.7
Neuroticism 0.4 0.9 3.1 0.4 -1.0 -1.8 -0.5 0.3
Chronotype (morning person) 0.0 0.1 0.3 -0.5 -0.1 0.0 -0.5 -0.2
Hair Pigment 1.1 32.5 92.4 -9.6 1.2 5.9 -4.2 -4.0
Tanning 0.1 1.3 3.0 1.7 1.4 1.0 0.2 0.8
Hand grip strength (left) 0.7 2.0 5.3 -1.9 -0.4 -0.8 2.3 0.1
Number of treatments/medications taken 0.1 0.2 0.6 0.8 -0.2 -0.2 -0.4 -0.1
Average weekly spirits intake 0.1 0.2 0.5 0.2 -0.6 -0.0 0.1 -0.7
Sensitivity / hurt feelings 0.5 0.9 2.4 -0.5 0.2 1.2 -1.6 -0.6
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.2 -0.1 -1.0 -1.5 -0.7 0.2
Hearing difficulty/problems: Yes 1.2 1.8 2.7 -1.6 -1.3 0.1 -1.4 -1.7
Relative age of first facial hair 1.0 2.0 4.6 -1.9 -0.2 0.8 -2.1 -0.9
Other serious medical condition/disability diagnosed by doctor 2.5 3.2 6.0 -1.1 -1.9 -0.2 -2.4 -2.3
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.2 -0.4 -1.1 -0.4 -1.1 -1.0
Ever had hysterectomy (womb removed) 1.7 1.9 7.8 -0.3 -0.8 0.3 -2.8 -1.0
Systolic blood pressure, automated reading 0.7 2.2 7.5 -0.0 -1.3 1.2 -0.4 -2.7
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.1 -1.0 -0.5 0.6 -0.7 -1.1
Angina 0.6 0.8 2.2 0.4 1.3 1.5 -0.1 0.3
Medication for hormone replacement therapy 0.4 0.5 1.1 -1.0 0.6 0.7 -0.7 0.3
Vitamin and mineral supplements 0.2 0.2 0.4 -0.0 0.7 0.2 0.5 0.6
Supplements: Zinc 1.5 1.6 3.3 -0.9 1.8 1.1 -0.5 1.5
Medication: Co-codamol 0.3 0.3 0.6 0.6 0.7 0.3 -0.0 0.8
Medication: Metformin 3.9 5.5 16.1 -4.0 -0.9 0.9 -2.2 -2.2
Diabetes (father) 0.9 1.1 4.1 -0.8 0.1 0.7 -2.0 -0.5
Diabetes (mother) 0.5 0.6 2.0 -0.4 0.3 0.8 -1.4 -0.4
Severe depression (siblings) 0.8 0.8 1.6 0.4 0.2 -1.0 1.2 1.2
Pack years adult smoking proportion 0.2 0.3 0.6 -0.4 0.6 -0.3 0.3 0.8
Impedance of leg (right) 0.4 2.1 6.7 -1.0 -0.6 -1.5 2.6 0.5
Leg fat-free mass (left) 0.4 2.0 5.1 0.0 2.2 1.5 -0.6 1.5
Trunk fat percentage 0.4 1.5 2.7 1.2 0.2 -1.5 0.9 1.6
Hand grip strength (right) 1.1 2.9 6.6 -1.5 -0.3 -2.0 2.6 1.3
Townsend deprivation index at recruitment 1.1 1.5 3.0 0.9 0.6 -1.2 1.4 1.7
Current tobacco smoking 0.8 1.4 4.0 0.7 -0.8 -2.0 1.1 0.7
Average weekly fortified wine intake 1.1 1.3 3.1 0.4 1.6 1.8 -0.1 0.6
Maternal smoking around birth 0.3 0.5 1.2 -0.6 1.1 0.5 -0.3 0.7
Fed-up feelings 1.6 3.0 7.0 1.7 -2.1 -2.7 -0.6 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.3 7.3 0.1 -2.0 -2.7 -0.4 -0.2
Relative age voice broke 1.9 2.9 6.0 -2.4 -2.0 -1.8 -0.5 -0.9
Taking other prescription medications 0.6 0.9 2.9 -0.3 0.7 0.9 -1.7 0.3
Age when periods started (menarche) 1.6 3.9 15.1 -3.9 -1.2 -0.1 -0.5 -1.6
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.8 0.8 -0.7 -0.1 -1.7 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 2.0 0.2 0.1 -0.4 -1.4 0.5
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.4 0.6 0.6 0.2 -0.3 0.7
Qualifications: CSEs or equivalent 0.5 0.7 1.3 -0.8 -1.1 -1.1 -0.1 -0.6
Serious illness, injury or assault to yourself 1.0 1.2 2.5 1.0 0.3 -1.1 -1.1 1.6
High blood pressure 0.4 1.1 3.6 -1.0 -0.0 -0.7 1.9 0.4
Hayfever, allergic rhinitis or eczema 0.9 2.0 2.8 1.5 1.7 0.8 -1.3 1.7
Multivitamins +/- minerals 0.2 0.3 0.9 -0.1 -0.6 0.3 -0.2 -1.0
Stomach or abdominal pain in last month 5.2 6.4 14.2 0.3 3.5 3.8 -2.1 1.2
Supplements: Glucosamine 2.7 3.6 9.3 -0.2 0.7 2.6 -3.0 -1.2
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.5 0.6 0.7 0.4 0.2 0.3
Medication: Atenolol 0.9 1.2 2.8 -1.7 -0.2 1.1 -0.3 -1.3
Medication: Levothyroxine sodium 5.4 9.2 24.2 -2.2 0.3 3.3 -4.9 -2.4
Sitting height 0.8 5.8 16.7 -1.2 3.0 4.1 -1.4 0.3
Chronic bronchitis/emphysema (father) 1.2 1.5 4.5 -0.9 -1.0 -2.1 0.8 0.6
High blood pressure (mother) 0.3 0.4 0.9 -0.9 -0.7 -0.2 -0.2 -0.7
Body mass index (BMI) 0.4 1.7 3.5 1.8 -0.3 -1.9 -0.3 1.1
Impedance of leg (left) 0.7 3.3 7.5 -1.2 -1.7 -2.1 2.7 -0.3
Leg predicted mass (left) 0.4 2.1 5.1 -0.1 2.3 1.5 -0.7 1.5
Trunk fat mass 0.2 0.9 2.3 0.7 0.5 -1.1 0.6 1.5
Waist circumference 0.0 0.1 0.3 0.5 0.2 0.2 -0.4 0.1
Number of incorrect matches in round 0.6 0.9 3.7 -0.3 -0.7 -1.9 0.2 0.6
Past tobacco smoking 1.0 1.9 5.7 2.4 -0.2 -0.8 1.5 0.8
Alcohol usually taken with meals 1.6 2.6 5.6 1.5 2.4 1.6 -0.1 1.6
Nervous feelings 0.1 0.3 0.4 0.1 0.6 0.3 -0.6 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.8 0.7 -0.1 -1.4 -0.3 1.1
Hearing difficulty/problems with background noise 0.0 0.0 0.0 -0.1 -0.0 0.0 -0.0 0.1
Hair/balding pattern: Pattern 2 1.2 1.5 5.3 -2.3 -0.4 -0.4 1.5 -0.1
Had menopause 1.1 1.4 3.5 0.8 -1.9 -1.1 -0.4 -1.2
Had other major operations 2.8 3.5 7.7 1.3 2.0 2.8 -1.9 0.4
Forced vital capacity (FVC) 0.4 1.5 7.5 -2.7 -0.1 0.2 0.2 -0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.6 -0.5 0.1 -0.5 -0.8 0.7
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.1 0.5 -0.7 -0.3 -1.1 -0.6
Qualifications: None of the above 0.5 1.1 1.7 1.3 -1.3 -1.1 0.5 -0.7
Financial difficulties in last 2 years 0.3 0.4 0.8 0.4 0.9 0.5 0.5 0.8
Mouth/teeth dental problems 0.4 0.6 3.0 -1.7 -0.0 0.0 -0.2 0.1
Heart attack 0.8 1.0 3.0 -0.4 1.3 1.7 -0.3 0.1
Allergy 1.2 2.7 5.7 -0.3 -1.9 -1.7 2.4 -1.1
Pain all over the body in last month 0.3 0.4 1.2 0.1 -0.7 -1.1 -0.2 0.1
Diabetes (self-reported) 2.4 3.7 7.0 -2.6 0.4 1.9 -2.6 -1.1
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 3.8 1.4 0.5 1.9 -1.9 -0.9
Medication: Ramipril 0.4 0.5 0.8 -0.8 -0.9 -0.5 -0.5 -0.8
Medication: Simvastatin 1.0 1.5 2.6 -1.3 -1.6 -0.7 -0.3 -1.5
Fluid intelligence score 0.5 1.1 2.3 -0.4 -1.5 -1.5 0.8 -0.5
Illnesses of siblings 1.3 1.9 3.7 1.9 1.6 0.6 0.8 1.5
Neuroticism score 0.4 0.9 2.2 0.1 -1.1 -1.5 -0.9 -0.1
Weight 0.1 0.5 1.5 0.4 0.9 -0.2 -0.0 1.2
Impedance of arm (right) 0.4 2.0 4.0 -0.9 2.0 1.8 1.0 1.1
Arm fat percentage (right) 0.3 1.3 2.8 1.7 0.1 -1.5 0.1 1.3
Trunk fat-free mass 0.1 0.7 1.7 -0.6 1.0 1.3 -0.8 0.1
Hip circumference 0.2 0.7 1.6 1.1 0.8 -0.3 -0.2 1.3
Time employed in main current job 0.9 1.1 2.3 0.7 -0.1 -1.5 1.2 1.0
Alcohol intake versus 10 years previously 0.5 0.7 1.6 0.1 -1.0 -0.1 -1.0 -1.3
Father’s age at death 0.2 0.3 1.1 1.0 0.3 0.4 0.1 -0.0
Worrier / anxious feelings 0.5 1.0 3.4 0.3 -0.7 -1.9 -0.3 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 3.3 -0.3 -0.5 -0.5 -1.8 -0.2
Falls in the last year 1.2 1.7 2.1 1.4 -1.5 -1.3 -1.4 -0.7
Hair/balding pattern: Pattern 3 1.6 2.4 7.2 1.2 1.6 2.7 -0.8 -0.1
Number of live births 0.3 0.4 1.0 0.0 -1.0 -0.7 -0.1 -0.6
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 3.5 -1.9 0.0 1.2 -0.9 -1.0
Pulse rate 13.4 22.5 66.1 2.4 -4.1 -8.1 4.5 2.0
Happiness 1.0 1.2 4.0 2.0 0.5 -0.6 0.3 1.2
Noisy workplace 0.3 0.4 0.9 0.1 0.9 0.7 0.4 0.6
Qualifications: A levels/AS levels or equivalent 0.7 1.6 5.6 -0.5 0.9 2.4 -0.6 -0.9
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.7 3.2 1.2 1.8 1.8 -0.2 0.8
Mouth/teeth dental problems: Dentures 0.6 1.0 2.8 1.7 -0.2 0.9 -0.5 -1.1
Asthma 0.2 0.3 0.6 -0.3 0.8 0.3 0.3 0.8
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.4 -1.0 1.0 1.6 -0.5 -0.0
Medication: Cholesterol lowering 0.6 0.9 2.7 -1.6 -0.7 0.1 -0.1 -1.2
Depression (self-reported) 0.4 0.5 0.9 1.0 -0.3 -0.8 -0.8 0.2
Medication: Lansoprazole 1.4 1.6 5.5 2.4 -0.5 -1.3 -0.4 0.5
Prospective memory result 1.4 1.8 5.3 1.2 -1.3 -2.3 0.6 0.2
Lung cancer (father) 1.7 2.0 4.8 -0.0 -2.2 -1.3 0.4 -1.8
Illnesses of mother 0.5 0.6 1.4 0.3 1.2 0.4 -0.3 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 4.0 -2.0 -0.1 1.4 -0.6 -1.3
Pulse wave Arterial Stiffness index 2.1 2.5 5.8 -0.1 1.5 -0.6 2.0 2.4
Impedance of arm (left) 0.5 2.2 3.0 -1.6 1.7 1.5 1.4 0.9
Arm fat mass (right) 0.2 0.8 1.5 1.2 0.2 -1.1 0.1 1.1
Trunk predicted mass 0.1 0.7 1.6 -0.6 1.0 1.3 -0.8 0.1
Standing height 0.6 6.1 13.1 -3.1 2.7 3.6 0.5 0.3
Length of working week for main job 0.5 0.6 1.4 -1.2 -0.8 -0.3 -0.4 -0.7
Exposure to tobacco smoke at home 0.6 0.7 1.5 0.7 1.1 1.2 -0.6 0.4
Breastfed as a baby 1.8 2.2 4.5 2.1 1.6 1.7 0.6 0.8
Tense / ‘highly strung’ 0.6 1.0 2.2 1.5 0.4 -1.0 0.3 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.6 0.3 -0.4 -0.3 -1.3 -0.2
Hair/balding pattern: Pattern 4 0.3 0.7 1.7 1.3 0.4 -0.5 0.4 1.1
Birth weight of first child 0.3 0.6 1.4 -0.5 -1.2 -0.5 -0.3 -1.0
Peak expiratory flow (PEF) 0.8 1.8 4.5 -0.9 0.9 2.1 -1.5 -0.6
Pulse wave reflection index 1.0 1.2 2.7 -0.5 1.6 1.0 -0.9 1.1
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.8 -0.6 -0.8 -0.4 -1.4 -0.8
Loud music exposure frequency 0.4 0.4 1.0 -1.0 0.6 0.1 0.3 0.8
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 2.0 -1.4 0.6 1.4 -0.6 -0.4
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 3.0 0.8 -0.2 0.6 -1.7 -0.8
Blood clot in the leg (DVT) 4.4 5.7 15.5 -1.8 -0.3 2.1 -3.9 -2.3
Medication: Paracetamol 0.6 0.9 2.4 0.7 1.3 0.2 0.4 1.5
Headache pain in last month 0.3 0.5 1.4 0.1 -0.4 0.5 -1.2 -0.8
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 7.0 2.6 0.4 -0.1 -0.5 0.8
Glaucoma (self-reported) 1.6 1.8 5.0 2.2 0.7 -0.7 0.2 1.7
Gout (self-reported) 0.1 0.2 0.7 0.2 -0.3 -0.4 0.8 0.0
Hypothyroidism/myxoedema (self-reported) 7.4 14.4 29.4 -3.4 1.8 4.9 -5.4 -2.0
Medication: Amlodipine 0.9 1.3 3.0 -0.0 -1.1 -1.7 1.6 -0.1
Medication: Ventolin 100micrograms inhaler 0.8 1.1 5.2 -2.3 -0.2 -0.1 -0.2 -0.3
Birth weight 0.3 0.7 2.6 -1.6 -0.4 -0.5 0.7 -0.0
Chronic bronchitis/emphysema (mother) 1.5 1.8 4.4 -0.0 -0.1 -2.1 1.4 1.5
High blood pressure (siblings) 2.1 3.1 5.5 -1.9 -1.6 0.5 -1.9 -2.3
Forced vital capacity (FVC), Best measure 0.7 2.4 10.6 -3.3 -0.2 0.7 0.1 -0.9
Body fat percentage 0.6 2.3 5.2 1.5 -0.2 -2.3 1.0 1.7
Leg fat percentage (right) 1.2 4.4 13.0 1.6 -1.1 -3.6 1.5 1.8
Arm fat-free mass (right) 0.0 0.1 0.2 -0.1 0.4 -0.1 -0.1 0.5
Exposure to tobacco smoke outside home 0.2 0.3 1.0 -1.0 0.1 -0.2 0.3 0.3
Comparative body size at age 10 0.4 1.0 2.7 0.5 -1.1 -0.5 -1.6 -0.9
Number of full brothers 0.3 0.4 0.9 -0.7 -0.6 0.0 -0.6 -1.0
Worry too long after embarrassment 0.4 0.7 1.7 0.8 -0.1 -1.3 0.6 1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 1.3 -1.1 -1.1 -0.9 -0.3 -0.6
Wheeze or whistling in the chest in last year 1.0 1.7 4.6 0.2 0.6 -1.6 1.0 2.2
Number of children fathered 0.5 0.6 2.0 0.6 0.7 1.4 -0.4 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 2.4 2.8 5.8 1.3 1.9 0.1 1.8 2.4
Age at first live birth 1.7 3.0 9.2 -0.8 1.6 3.0 -1.6 -0.5
Pulse wave peak to peak time 2.2 2.6 6.6 -0.2 -1.5 0.8 -1.9 -2.6
Health satisfaction 0.6 0.7 3.2 -0.2 -0.4 -0.0 -1.8 -0.5
Shortness of breath walking on level ground 0.4 0.5 1.1 0.1 -1.0 -1.0 -0.4 -0.5
Qualifications: College or University degree 1.0 3.0 7.3 -1.0 2.2 2.7 -1.1 0.6
Eye problems/disorders: None of the above 0.3 0.3 0.8 0.9 -0.2 -0.4 0.8 0.2
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.7 0.4 -0.0 -0.8 0.3 0.5
Emphysema/chronic bronchitis 1.2 1.3 4.9 -2.2 0.1 0.9 -0.6 -0.7
Medication for pain relief, constipation, heartburn 0.6 1.1 2.7 1.0 -1.2 -1.6 0.5 -0.1
Neck or shoulder pain in last month 0.7 1.0 3.2 0.9 -0.7 -0.4 -1.8 -0.5
Medication: Blood pressure 0.9 1.6 5.9 -2.4 0.7 0.5 1.2 0.2
Angina (self-reported) 0.6 0.8 2.3 0.5 1.1 1.5 -0.2 0.1
Migraine (self-reported) 0.5 0.7 2.8 1.7 0.4 0.3 -0.4 0.4
Medication: Ibuprofen 0.5 0.6 1.3 -0.0 1.2 1.2 0.1 0.6
Medication: Allopurinol 0.2 0.3 0.4 -0.7 -0.5 -0.2 0.5 -0.6
Medication: Omeprazole 1.2 1.4 3.3 -0.1 1.6 1.8 -0.9 0.7
Medication: Seretide 50 evohaler 0.3 0.3 0.8 0.3 0.2 -0.7 0.5 0.9
Mean time to correctly identify matches 1.4 2.7 9.7 0.7 -1.5 -3.1 -0.3 1.0
Heart disease (mother) 0.1 0.1 0.4 -0.6 0.1 0.2 0.4 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.8 1.8 -0.3 -1.3 -0.5 -0.1 -1.4
Whole body fat mass 0.4 1.5 3.0 1.2 0.3 -1.6 0.6 1.7
Leg fat mass (right) 0.5 2.0 5.2 1.4 -0.3 -2.3 0.6 1.5
Arm predicted mass (right) 0.0 0.1 0.4 -0.1 0.5 -0.1 0.0 0.6
Pulse rate, automated reading 20.6 66.4 196.0 3.7 -8.3 -14.0 7.2 1.5
Alcohol intake frequency. 0.2 0.4 0.8 0.7 -0.9 -0.2 -0.5 -0.7
Comparative height size at age 10 0.4 2.1 8.0 -0.6 1.3 2.8 -0.3 -0.7
Number of full sisters 0.4 0.5 1.8 -1.3 0.4 0.6 -0.2 -0.1
Suffer from ‘nerves’ 0.7 1.1 3.6 0.9 -0.8 -1.9 0.0 0.7
Overall health rating 1.1 2.3 4.0 -0.1 -2.0 -1.8 -1.8 -1.0
Chest pain or discomfort 1.2 1.8 4.6 2.1 1.1 -0.3 0.2 1.7
Had major operations 0.4 0.5 1.1 0.3 0.5 -0.5 -1.0 1.0
Age at last live birth 0.1 0.1 0.3 -0.2 -0.3 0.1 0.5 -0.5
Family relationship satisfaction 0.9 1.1 2.6 1.1 -0.2 -1.6 0.6 1.0
Leg pain on walking 1.2 1.6 4.3 1.5 0.6 0.9 -2.1 0.0
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 2.0 0.1 -1.3 -1.4 0.2 -0.6
Commuting to job workplace: Car/motor vehicle 1.1 1.2 4.0 2.0 0.6 -0.1 0.9 0.9
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.6 -0.7 -0.8 -0.4 0.7 -0.6
Medication: Aspirin 1.0 1.4 2.3 -1.4 0.2 1.2 -1.5 -1.0
Supplements: Vitamin C 0.2 0.2 0.7 0.6 -0.0 0.0 -0.8 -0.1
Knee pain experienced in last month 0.6 0.9 1.8 0.6 0.6 1.3 -1.3 -0.5
Hypertension (Self-reported) 0.5 1.5 4.6 -1.2 -0.0 -1.0 2.1 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 2.3 0.3 -0.1 1.5 -1.1 -1.5
Illnesses of father: Heart disease 0.5 0.7 2.0 1.4 0.4 -0.1 1.0 0.7
Illnesses of siblings: Diabetes 0.6 0.7 3.1 -0.0 -0.4 -0.4 -1.7 0.1
Smoking status: Previous 1.9 2.8 4.8 -2.0 0.7 2.0 -2.2 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 2.1 4.4 13.3 -3.6 -1.0 1.2 -0.3 -2.5
Whole body fat-free mass 0.2 0.9 2.0 -0.4 1.4 1.3 -0.7 0.6
Leg fat-free mass (right) 0.3 1.5 3.2 -0.3 1.8 1.7 -0.8 0.8
Arm fat percentage (left) 0.3 1.3 2.3 1.4 0.2 -1.5 0.3 1.4
Average weekly red wine intake 0.6 0.9 1.5 -1.2 -0.6 0.5 -0.9 -1.1
Handedness (chirality/laterality): Left-handed 1.6 1.9 4.5 0.2 -2.1 -1.9 0.5 -1.1
Mood swings 1.1 2.0 4.2 -1.9 -0.8 0.4 -2.0 -1.4
Loneliness, isolation 1.1 1.5 4.0 1.0 -1.5 -2.0 -0.7 -0.1
Long-standing illness, disability or infirmity 0.6 0.9 3.1 0.2 0.1 0.9 -1.8 -0.5
Ever had bowel cancer screening 1.0 1.1 2.4 -0.5 -1.1 -1.5 -1.3 -0.3
Diabetes diagnosed by doctor 2.9 4.8 8.7 -2.8 0.6 2.2 -2.9 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 2.0 0.1 1.4 1.4 -1.1 0.6
Friendships satisfaction 1.2 1.5 3.8 1.6 -0.8 -2.0 -0.2 0.7
Qualifications: nursing, teaching 0.5 0.7 2.0 -1.4 0.6 1.1 0.0 -0.1
Commuting to job workplace: Walk 0.1 0.1 0.2 -0.4 0.0 0.5 -0.4 -0.3
Eye problems/disorders: Cataract 0.8 0.9 3.9 -2.0 0.6 0.2 0.4 0.5
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.6 0.6 0.8 -0.2 1.3 1.3
Medication for cholesterol 0.8 1.2 3.4 0.1 1.5 1.8 -0.4 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.7 4.5 0.7 -1.6 -2.1 0.9 -0.3
Back pain experienced in last month 0.5 0.8 1.8 1.4 -0.1 -0.5 -1.3 0.2
Mineral and other dietary supplements 1.4 1.9 3.7 -0.9 0.6 -1.5 1.6 1.9
Breast cancer (self-reported) 0.3 0.3 0.6 0.7 -0.8 -0.5 0.2 -0.6
Asthma (self-reported) 0.1 0.2 0.5 -0.4 0.6 0.1 0.3 0.7
Osteoporosis (self-reported) 0.9 1.1 2.7 -0.4 -1.5 -1.6 0.2 -0.6
Osteoarthritis (self-reported) 1.2 1.6 4.2 1.5 -0.0 1.0 -2.1 -0.7
Medication: Aspirin 0.6 0.8 2.0 -0.9 -0.0 0.7 -1.4 -0.8
Medication: Gliclazide 1.0 1.1 3.4 -1.3 -0.4 0.1 -1.8 -0.7
Illnesses of father: None of the above (group 1) 0.3 0.3 1.6 1.3 0.1 0.3 -0.2 -0.1
Smoking status: Current 1.0 1.6 5.0 0.6 -1.0 -2.2 1.2 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.2 0.2 -1.5 -0.4 -0.3 -1.4
Whole body water mass 0.2 0.9 1.9 -0.4 1.4 1.2 -0.8 0.6
Leg predicted mass (right) 0.3 1.5 3.5 -0.3 1.9 1.7 -0.8 0.9
Arm fat mass (left) 0.2 0.9 1.9 1.0 0.0 -1.4 0.2 1.1
Number of self-reported non-cancer illnesses 0.7 1.2 3.7 -0.3 -0.3 0.9 -1.9 -1.1
Average weekly champagne plus white wine intake 2.0 2.8 6.2 -0.6 2.5 2.5 0.3 1.1
Miserableness 0.9 1.6 3.4 -0.5 -1.7 -1.9 -1.0 -0.6
Guilty feelings 0.8 1.2 3.1 0.7 -0.2 -1.8 0.3 1.5
Wears glasses or contact lenses 0.1 0.2 0.3 0.6 -0.1 -0.4 0.3 0.5
Ever taken oral contraceptive pill 1.4 1.6 4.2 -2.1 0.4 1.3 -1.3 -0.4
Hearing aid user 1.2 1.3 3.3 1.8 -0.7 -1.5 -0.8 0.3
Mother’s age at death 0.7 0.9 2.5 0.5 1.0 1.6 -0.7 0.0
Financial situation satisfaction 0.8 1.0 2.2 -0.2 -1.5 -0.8 0.6 -1.4
Tinnitus: Yes, now most or all of the time 0.5 0.6 2.0 -0.1 0.4 1.4 -0.2 -0.8
Commuting to job workplace: Public transport 0.2 0.3 0.6 0.5 0.7 0.8 -0.1 0.3
Eye problems/disorders: Glaucoma 0.9 1.1 2.5 1.6 0.3 -0.9 0.1 1.4
Medication: Blood pressure 0.2 0.4 1.3 0.3 -0.5 -1.1 0.4 0.4
Pain type(s) experienced in last month: Hip pain 0.6 0.8 2.3 1.5 -0.0 0.7 -1.0 -0.3
Supplements: Fish oil (including cod liver oil) 3.2 4.2 11.7 -0.1 -2.0 1.0 -2.0 -3.4
High cholesterol (Self-reported) 1.0 1.7 3.8 1.9 -0.9 -1.6 1.1 0.3
Medication: Bendroflumethiazide 0.1 0.2 0.4 -0.6 -0.1 -0.0 0.6 -0.1
Medication: Paracetamol 1.0 1.5 3.1 1.5 1.3 -0.2 0.6 1.8
Medication: Lisinopril 1.5 1.9 5.5 -2.3 1.3 0.9 0.7 1.0
Medication: Atorvastatin 1.7 2.1 4.1 0.8 -1.5 -2.0 1.8 -0.4
Illnesses of father: High blood pressure 0.5 0.6 2.3 -1.5 -0.6 -0.5 -0.1 -0.3
Alcohol drinker status: Never 0.7 0.8 2.8 0.7 0.8 1.7 0.3 -0.3
Ever smoked 1.2 2.1 6.5 -2.5 0.0 1.0 -1.3 -1.1
Basal metabolic rate 0.1 0.6 1.3 -0.2 1.2 0.8 -0.5 0.7
Leg fat percentage (left) 1.3 4.6 15.0 1.4 -1.6 -3.9 1.4 1.3
Arm fat-free mass (left) 0.0 0.1 0.2 0.1 0.2 -0.2 -0.3 0.4
Number of operations (self-reported) 1.8 2.7 9.0 0.1 1.5 1.1 -3.0 1.1
Average weekly beer plus cider intake 1.0 1.4 5.3 -0.5 -0.2 -1.1 2.3 0.5
Irritability 0.2 0.3 0.7 -0.4 0.1 -0.4 -0.8 0.6
Risk taking 0.8 1.2 2.4 -1.1 0.2 -1.5 -0.4 1.6
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.5 0.1 -0.5 -0.7 0.5 -0.0
Fractured/broken bones in last 5 years 0.6 0.8 1.7 1.3 -0.9 -1.0 -0.7 -0.4
Age started oral contraceptive pill 0.9 1.1 2.4 -0.5 -1.5 -0.9 1.1 -1.0
Diastolic blood pressure, automated reading 4.3 13.5 26.8 2.3 -1.0 -5.0 5.2 3.1
Ever depressed for a whole week 0.4 0.5 1.0 -0.7 0.3 0.8 -1.0 -0.4
Unable to work because of sickness or disability 0.2 0.3 0.7 0.4 -0.7 -0.8 -0.6 -0.1
Commuting to job workplace: Cycle 1.0 1.2 2.1 -1.1 -1.1 -0.1 -1.5 -1.3
Myopia 0.3 0.4 1.0 -1.0 -0.1 0.1 -1.0 0.0
Vascular/heart problems diagnosed by doctor 0.4 1.0 2.8 1.3 0.1 0.7 -1.7 -0.4
Cholesterol lowering medication 3.1 4.5 12.4 0.2 -2.8 -3.5 1.3 -0.7
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.8 -0.1 1.4 1.7 -0.8 0.4
Pain experienced in last month 0.2 0.4 0.9 -0.8 0.5 0.2 0.9 0.5
Supplements: Calcium 0.4 0.5 0.8 -0.3 -0.9 -0.5 -0.9 -0.7
Basal cell carcinoma (self-reported) 0.3 0.4 1.8 -0.1 0.2 0.3 1.3 0.0
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.5 -0.4 1.2 1.6 -0.2 0.1
Deep venous thrombosis (DVT) (self-reported) 4.2 5.4 16.3 -1.6 -0.1 2.1 -4.0 -2.0
Heart disease (siblings) 0.6 0.7 2.0 -0.9 -0.3 -0.8 1.4 0.2
Alcohol drinker status: Previous 0.8 1.0 2.3 -0.4 -1.5 -0.6 -0.5 -1.3
Pack years of smoking 0.1 0.1 0.3 -0.6 0.3 -0.1 0.0 0.3
Impedance of whole body 0.3 1.5 4.9 -1.4 0.4 -0.1 2.2 0.7
Leg fat mass (left) 0.5 1.9 5.8 1.2 -0.6 -2.4 0.6 1.2
Arm predicted mass (left) 0.0 0.2 0.5 0.4 0.6 0.0 -0.1 0.7