Hub : Genes

GNB2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0390	0.0165	0.00041	-0.001	0.011	0.003	0.012	-0.001	0.8600	9.7e-05	0.0300	6.5e-05	0.570
2	TCGA	Bladder Urothelial Carcinoma	0.0380	0.0250	0.00620	0.025	0.012	0.019	NA	0.013	0.0033	3.2e-02	0.0095	NA	0.026
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0261	0.0158	0.00290	0.007	0.022	0.015	NA	0.011	0.0530	1.3e-03	0.0077	NA	0.020
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1450	0.0740	0.00710	0.005	0.008	0.005	NA	-0.005	0.1500	1.0e-01	0.1600	NA	0.800
5	TCGA	Brain Lower Grade Glioma	0.0178	0.0113	0.00830	0.006	0.013	0.002	NA	0.003	0.0550	1.2e-02	0.1700	NA	0.130

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.7	1.9	0.8	-0.5	-1.4	0.5	0.6
Bipolar Disorder or Schizophrenia	2.4	5.9	17.3	2.3	-1.6	-4.2	1.4	1.6
Depressed Affect (Nagel 2018)	0.8	1.6	2.7	-0.7	-1.6	-1.2	-1.6	-0.9
Depression (Nagel 2018)	0.8	1.3	4.5	0.1	-1.0	-2.1	-0.1	0.8
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.6	-1.4	0.6	1.6	0.7	-0.7
Neuroticism (Nagel 2018)	0.2	0.4	0.9	-0.6	-0.4	-0.9	-0.8	0.4
Schizophrenia (2018)	2.9	6.0	17.8	2.3	-1.6	-4.2	1.4	1.6
Schizophrenia vs Biploar Disorder	2.5	3.3	6.4	1.5	0.5	-2.0	1.9	2.5
Worry (Nagel 2018)	0.3	0.6	1.4	1.2	0.1	-0.9	0.2	0.9
Alzheimer’s Disease (in mother)	1.6	1.8	6.2	2.5	0.9	1.5	-0.3	-0.2
Alzheimer’s Disease (in father)	1.0	1.1	2.5	0.5	0.5	1.4	-1.6	-0.6
Alzheimer’s Disease (including proxy)	2.3	3.3	8.9	3.0	0.3	1.8	-1.7	-1.1
Crohns Disease (2017)	2.6	5.6	15.1	1.7	-1.3	-3.9	2.4	1.7
Irritable Bowel Disease (IBD)	2.3	5.5	19.0	0.5	-2.5	-4.4	1.3	0.5
Ulcerative Colitis (UC)	1.8	3.4	7.6	-1.0	-2.6	-2.8	-0.6	-1.1
Major Depression (MDD)	1.0	1.2	1.8	-1.3	-1.1	-1.2	-1.2	-0.3
Reaction Time	1.6	3.0	10.8	0.3	-0.9	-3.3	-0.5	1.7
Verbal and Numeric Reasoning (VNR)	0.3	0.6	0.9	-1.0	0.7	0.9	1.0	0.2
Breast Cancer	1.1	2.6	5.5	-1.1	2.3	1.0	-1.0	2.1
Ovarian Cancer	0.7	0.9	3.1	-0.8	0.7	1.8	-0.3	-0.4
Prostate Cancer	0.7	0.9	2.0	1.3	-0.5	-1.4	0.7	0.5
Age at First Birth	3.8	5.5	10.4	-2.5	-1.3	1.7	-2.5	-3.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	-0.1	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	2.9	4.6	7.5	2.7	0.2	-2.5	1.6	2.5
Mean Putamen Volume	0.9	1.0	1.7	-0.7	1.3	0.2	1.1	1.3
Fasting Glucose	2.3	2.8	7.2	-2.7	0.2	1.3	-1.9	-1.1
HbA1C	1.4	1.6	3.1	1.2	1.4	0.3	-1.1	1.8
HDL Cholesterol	0.4	0.6	3.0	1.7	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.1	0.4	0.0	0.0	0.0	0.0
Lupus	0.6	0.8	2.7	0.6	0.7	0.6	-1.6	0.5
Neuroticism (2016)	1.7	2.5	7.7	-2.8	-1.4	-1.7	-0.1	-0.3
Primary Biliary Cirrhosis	0.7	1.0	2.6	-1.6	-0.0	1.1	-0.3	-1.0
Rheumatoid Arthritis	2.6	3.5	9.2	-1.4	-1.3	0.5	-3.0	-2.1
Schizophrenia (2014)	3.5	7.7	22.1	2.0	-1.5	-4.7	2.3	2.2
Triglycerides	0.0	0.1	0.3	0.5	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	0.7	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.8	1.2	3.6	0.2	-1.1	-1.9	-1.1	0.2
Blood Eosinophil Count	1.1	8.6	22.6	2.8	-1.4	-4.8	2.2	2.5
Blood Platelet Count	5.9	68.0	201.6	-2.9	-10.6	0.0	-4.2	-14.2
Blood Red Count	56.9	549.2	1560.2	19.4	25.0	-7.4	11.4	39.5
Blood White Count	0.7	5.4	13.2	1.6	0.6	-3.2	0.6	3.6
Heel T-Score	0.7	5.9	18.9	-0.3	2.3	1.1	-4.3	2.0
BMI	0.8	4.6	10.5	2.8	1.4	-1.7	0.3	3.2
Height	0.4	8.1	22.2	-3.2	2.5	4.7	1.1	-0.9
Waist Hip Ratio (WHR)	0.8	3.5	9.4	-3.1	0.6	2.3	0.2	-1.5
Systolic Blood Pressure	0.8	4.0	11.1	-1.8	0.5	3.3	-0.6	-2.3
Smoking Status	0.7	1.7	5.2	-0.7	-1.6	-2.3	0.3	-0.3
Allergy or Eczema	0.6	1.6	2.3	1.5	1.4	0.8	-1.3	1.2
Cardiovascular Disease	0.5	1.7	5.1	-0.4	-0.1	-1.5	2.2	1.1
Hypothyroidism (self reported)	7.2	16.6	30.9	-3.9	1.7	5.3	-5.6	-2.4
Respiratory disease	0.2	0.4	1.7	-1.3	-0.3	-0.2	-0.0	-0.2
Type 2 Diabetes (T2D) (2018)	3.0	5.6	9.4	-3.1	1.6	2.6	-3.0	-0.2
Lung FEV1/FVC ratio	0.5	2.6	5.3	2.3	-1.5	0.3	-1.1	-2.1
Lung FVC	0.6	2.8	4.5	-2.0	-2.0	-2.1	1.1	-0.7
Neuroticism	0.4	0.9	3.1	0.4	-1.0	-1.8	-0.5	0.3
Chronotype (morning person)	0.0	0.1	0.3	-0.5	-0.1	0.0	-0.5	-0.2
Hair Pigment	1.1	32.5	92.4	-9.6	1.2	5.9	-4.2	-4.0
Tanning	0.1	1.3	3.0	1.7	1.4	1.0	0.2	0.8
Hand grip strength (left)	0.7	2.0	5.3	-1.9	-0.4	-0.8	2.3	0.1
Number of treatments/medications taken	0.1	0.2	0.6	0.8	-0.2	-0.2	-0.4	-0.1
Average weekly spirits intake	0.1	0.2	0.5	0.2	-0.6	-0.0	0.1	-0.7
Sensitivity / hurt feelings	0.5	0.9	2.4	-0.5	0.2	1.2	-1.6	-0.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.2	-0.1	-1.0	-1.5	-0.7	0.2
Hearing difficulty/problems: Yes	1.2	1.8	2.7	-1.6	-1.3	0.1	-1.4	-1.7
Relative age of first facial hair	1.0	2.0	4.6	-1.9	-0.2	0.8	-2.1	-0.9
Other serious medical condition/disability diagnosed by doctor	2.5	3.2	6.0	-1.1	-1.9	-0.2	-2.4	-2.3
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.2	-0.4	-1.1	-0.4	-1.1	-1.0
Ever had hysterectomy (womb removed)	1.7	1.9	7.8	-0.3	-0.8	0.3	-2.8	-1.0
Systolic blood pressure, automated reading	0.7	2.2	7.5	-0.0	-1.3	1.2	-0.4	-2.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.1	-1.0	-0.5	0.6	-0.7	-1.1
Angina	0.6	0.8	2.2	0.4	1.3	1.5	-0.1	0.3
Medication for hormone replacement therapy	0.4	0.5	1.1	-1.0	0.6	0.7	-0.7	0.3
Vitamin and mineral supplements	0.2	0.2	0.4	-0.0	0.7	0.2	0.5	0.6
Supplements: Zinc	1.5	1.6	3.3	-0.9	1.8	1.1	-0.5	1.5
Medication: Co-codamol	0.3	0.3	0.6	0.6	0.7	0.3	-0.0	0.8
Medication: Metformin	3.9	5.5	16.1	-4.0	-0.9	0.9	-2.2	-2.2
Diabetes (father)	0.9	1.1	4.1	-0.8	0.1	0.7	-2.0	-0.5
Diabetes (mother)	0.5	0.6	2.0	-0.4	0.3	0.8	-1.4	-0.4
Severe depression (siblings)	0.8	0.8	1.6	0.4	0.2	-1.0	1.2	1.2
Pack years adult smoking proportion	0.2	0.3	0.6	-0.4	0.6	-0.3	0.3	0.8
Impedance of leg (right)	0.4	2.1	6.7	-1.0	-0.6	-1.5	2.6	0.5
Leg fat-free mass (left)	0.4	2.0	5.1	0.0	2.2	1.5	-0.6	1.5
Trunk fat percentage	0.4	1.5	2.7	1.2	0.2	-1.5	0.9	1.6
Hand grip strength (right)	1.1	2.9	6.6	-1.5	-0.3	-2.0	2.6	1.3
Townsend deprivation index at recruitment	1.1	1.5	3.0	0.9	0.6	-1.2	1.4	1.7
Current tobacco smoking	0.8	1.4	4.0	0.7	-0.8	-2.0	1.1	0.7
Average weekly fortified wine intake	1.1	1.3	3.1	0.4	1.6	1.8	-0.1	0.6
Maternal smoking around birth	0.3	0.5	1.2	-0.6	1.1	0.5	-0.3	0.7
Fed-up feelings	1.6	3.0	7.0	1.7	-2.1	-2.7	-0.6	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	7.3	0.1	-2.0	-2.7	-0.4	-0.2
Relative age voice broke	1.9	2.9	6.0	-2.4	-2.0	-1.8	-0.5	-0.9
Taking other prescription medications	0.6	0.9	2.9	-0.3	0.7	0.9	-1.7	0.3
Age when periods started (menarche)	1.6	3.9	15.1	-3.9	-1.2	-0.1	-0.5	-1.6
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.8	0.8	-0.7	-0.1	-1.7	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.0	0.2	0.1	-0.4	-1.4	0.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.6	0.6	0.2	-0.3	0.7
Qualifications: CSEs or equivalent	0.5	0.7	1.3	-0.8	-1.1	-1.1	-0.1	-0.6
Serious illness, injury or assault to yourself	1.0	1.2	2.5	1.0	0.3	-1.1	-1.1	1.6
High blood pressure	0.4	1.1	3.6	-1.0	-0.0	-0.7	1.9	0.4
Hayfever, allergic rhinitis or eczema	0.9	2.0	2.8	1.5	1.7	0.8	-1.3	1.7
Multivitamins +/- minerals	0.2	0.3	0.9	-0.1	-0.6	0.3	-0.2	-1.0
Stomach or abdominal pain in last month	5.2	6.4	14.2	0.3	3.5	3.8	-2.1	1.2
Supplements: Glucosamine	2.7	3.6	9.3	-0.2	0.7	2.6	-3.0	-1.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	0.6	0.7	0.4	0.2	0.3
Medication: Atenolol	0.9	1.2	2.8	-1.7	-0.2	1.1	-0.3	-1.3
Medication: Levothyroxine sodium	5.4	9.2	24.2	-2.2	0.3	3.3	-4.9	-2.4
Sitting height	0.8	5.8	16.7	-1.2	3.0	4.1	-1.4	0.3
Chronic bronchitis/emphysema (father)	1.2	1.5	4.5	-0.9	-1.0	-2.1	0.8	0.6
High blood pressure (mother)	0.3	0.4	0.9	-0.9	-0.7	-0.2	-0.2	-0.7
Body mass index (BMI)	0.4	1.7	3.5	1.8	-0.3	-1.9	-0.3	1.1
Impedance of leg (left)	0.7	3.3	7.5	-1.2	-1.7	-2.1	2.7	-0.3
Leg predicted mass (left)	0.4	2.1	5.1	-0.1	2.3	1.5	-0.7	1.5
Trunk fat mass	0.2	0.9	2.3	0.7	0.5	-1.1	0.6	1.5
Waist circumference	0.0	0.1	0.3	0.5	0.2	0.2	-0.4	0.1
Number of incorrect matches in round	0.6	0.9	3.7	-0.3	-0.7	-1.9	0.2	0.6
Past tobacco smoking	1.0	1.9	5.7	2.4	-0.2	-0.8	1.5	0.8
Alcohol usually taken with meals	1.6	2.6	5.6	1.5	2.4	1.6	-0.1	1.6
Nervous feelings	0.1	0.3	0.4	0.1	0.6	0.3	-0.6	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.8	0.7	-0.1	-1.4	-0.3	1.1
Hearing difficulty/problems with background noise	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.0	0.1
Hair/balding pattern: Pattern 2	1.2	1.5	5.3	-2.3	-0.4	-0.4	1.5	-0.1
Had menopause	1.1	1.4	3.5	0.8	-1.9	-1.1	-0.4	-1.2
Had other major operations	2.8	3.5	7.7	1.3	2.0	2.8	-1.9	0.4
Forced vital capacity (FVC)	0.4	1.5	7.5	-2.7	-0.1	0.2	0.2	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.6	-0.5	0.1	-0.5	-0.8	0.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.1	0.5	-0.7	-0.3	-1.1	-0.6
Qualifications: None of the above	0.5	1.1	1.7	1.3	-1.3	-1.1	0.5	-0.7
Financial difficulties in last 2 years	0.3	0.4	0.8	0.4	0.9	0.5	0.5	0.8
Mouth/teeth dental problems	0.4	0.6	3.0	-1.7	-0.0	0.0	-0.2	0.1
Heart attack	0.8	1.0	3.0	-0.4	1.3	1.7	-0.3	0.1
Allergy	1.2	2.7	5.7	-0.3	-1.9	-1.7	2.4	-1.1
Pain all over the body in last month	0.3	0.4	1.2	0.1	-0.7	-1.1	-0.2	0.1
Diabetes (self-reported)	2.4	3.7	7.0	-2.6	0.4	1.9	-2.6	-1.1
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	3.8	1.4	0.5	1.9	-1.9	-0.9
Medication: Ramipril	0.4	0.5	0.8	-0.8	-0.9	-0.5	-0.5	-0.8
Medication: Simvastatin	1.0	1.5	2.6	-1.3	-1.6	-0.7	-0.3	-1.5
Fluid intelligence score	0.5	1.1	2.3	-0.4	-1.5	-1.5	0.8	-0.5
Illnesses of siblings	1.3	1.9	3.7	1.9	1.6	0.6	0.8	1.5
Neuroticism score	0.4	0.9	2.2	0.1	-1.1	-1.5	-0.9	-0.1
Weight	0.1	0.5	1.5	0.4	0.9	-0.2	-0.0	1.2
Impedance of arm (right)	0.4	2.0	4.0	-0.9	2.0	1.8	1.0	1.1
Arm fat percentage (right)	0.3	1.3	2.8	1.7	0.1	-1.5	0.1	1.3
Trunk fat-free mass	0.1	0.7	1.7	-0.6	1.0	1.3	-0.8	0.1
Hip circumference	0.2	0.7	1.6	1.1	0.8	-0.3	-0.2	1.3
Time employed in main current job	0.9	1.1	2.3	0.7	-0.1	-1.5	1.2	1.0
Alcohol intake versus 10 years previously	0.5	0.7	1.6	0.1	-1.0	-0.1	-1.0	-1.3
Father’s age at death	0.2	0.3	1.1	1.0	0.3	0.4	0.1	-0.0
Worrier / anxious feelings	0.5	1.0	3.4	0.3	-0.7	-1.9	-0.3	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.3	-0.3	-0.5	-0.5	-1.8	-0.2
Falls in the last year	1.2	1.7	2.1	1.4	-1.5	-1.3	-1.4	-0.7
Hair/balding pattern: Pattern 3	1.6	2.4	7.2	1.2	1.6	2.7	-0.8	-0.1
Number of live births	0.3	0.4	1.0	0.0	-1.0	-0.7	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	3.5	-1.9	0.0	1.2	-0.9	-1.0
Pulse rate	13.4	22.5	66.1	2.4	-4.1	-8.1	4.5	2.0
Happiness	1.0	1.2	4.0	2.0	0.5	-0.6	0.3	1.2
Noisy workplace	0.3	0.4	0.9	0.1	0.9	0.7	0.4	0.6
Qualifications: A levels/AS levels or equivalent	0.7	1.6	5.6	-0.5	0.9	2.4	-0.6	-0.9
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	3.2	1.2	1.8	1.8	-0.2	0.8
Mouth/teeth dental problems: Dentures	0.6	1.0	2.8	1.7	-0.2	0.9	-0.5	-1.1
Asthma	0.2	0.3	0.6	-0.3	0.8	0.3	0.3	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.4	-1.0	1.0	1.6	-0.5	-0.0
Medication: Cholesterol lowering	0.6	0.9	2.7	-1.6	-0.7	0.1	-0.1	-1.2
Depression (self-reported)	0.4	0.5	0.9	1.0	-0.3	-0.8	-0.8	0.2
Medication: Lansoprazole	1.4	1.6	5.5	2.4	-0.5	-1.3	-0.4	0.5
Prospective memory result	1.4	1.8	5.3	1.2	-1.3	-2.3	0.6	0.2
Lung cancer (father)	1.7	2.0	4.8	-0.0	-2.2	-1.3	0.4	-1.8
Illnesses of mother	0.5	0.6	1.4	0.3	1.2	0.4	-0.3	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	4.0	-2.0	-0.1	1.4	-0.6	-1.3
Pulse wave Arterial Stiffness index	2.1	2.5	5.8	-0.1	1.5	-0.6	2.0	2.4
Impedance of arm (left)	0.5	2.2	3.0	-1.6	1.7	1.5	1.4	0.9
Arm fat mass (right)	0.2	0.8	1.5	1.2	0.2	-1.1	0.1	1.1
Trunk predicted mass	0.1	0.7	1.6	-0.6	1.0	1.3	-0.8	0.1
Standing height	0.6	6.1	13.1	-3.1	2.7	3.6	0.5	0.3
Length of working week for main job	0.5	0.6	1.4	-1.2	-0.8	-0.3	-0.4	-0.7
Exposure to tobacco smoke at home	0.6	0.7	1.5	0.7	1.1	1.2	-0.6	0.4
Breastfed as a baby	1.8	2.2	4.5	2.1	1.6	1.7	0.6	0.8
Tense / ‘highly strung’	0.6	1.0	2.2	1.5	0.4	-1.0	0.3	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.6	0.3	-0.4	-0.3	-1.3	-0.2
Hair/balding pattern: Pattern 4	0.3	0.7	1.7	1.3	0.4	-0.5	0.4	1.1
Birth weight of first child	0.3	0.6	1.4	-0.5	-1.2	-0.5	-0.3	-1.0
Peak expiratory flow (PEF)	0.8	1.8	4.5	-0.9	0.9	2.1	-1.5	-0.6
Pulse wave reflection index	1.0	1.2	2.7	-0.5	1.6	1.0	-0.9	1.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.8	-0.6	-0.8	-0.4	-1.4	-0.8
Loud music exposure frequency	0.4	0.4	1.0	-1.0	0.6	0.1	0.3	0.8
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.0	-1.4	0.6	1.4	-0.6	-0.4
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.0	0.8	-0.2	0.6	-1.7	-0.8
Blood clot in the leg (DVT)	4.4	5.7	15.5	-1.8	-0.3	2.1	-3.9	-2.3
Medication: Paracetamol	0.6	0.9	2.4	0.7	1.3	0.2	0.4	1.5
Headache pain in last month	0.3	0.5	1.4	0.1	-0.4	0.5	-1.2	-0.8
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	7.0	2.6	0.4	-0.1	-0.5	0.8
Glaucoma (self-reported)	1.6	1.8	5.0	2.2	0.7	-0.7	0.2	1.7
Gout (self-reported)	0.1	0.2	0.7	0.2	-0.3	-0.4	0.8	0.0
Hypothyroidism/myxoedema (self-reported)	7.4	14.4	29.4	-3.4	1.8	4.9	-5.4	-2.0
Medication: Amlodipine	0.9	1.3	3.0	-0.0	-1.1	-1.7	1.6	-0.1
Medication: Ventolin 100micrograms inhaler	0.8	1.1	5.2	-2.3	-0.2	-0.1	-0.2	-0.3
Birth weight	0.3	0.7	2.6	-1.6	-0.4	-0.5	0.7	-0.0
Chronic bronchitis/emphysema (mother)	1.5	1.8	4.4	-0.0	-0.1	-2.1	1.4	1.5
High blood pressure (siblings)	2.1	3.1	5.5	-1.9	-1.6	0.5	-1.9	-2.3
Forced vital capacity (FVC), Best measure	0.7	2.4	10.6	-3.3	-0.2	0.7	0.1	-0.9
Body fat percentage	0.6	2.3	5.2	1.5	-0.2	-2.3	1.0	1.7
Leg fat percentage (right)	1.2	4.4	13.0	1.6	-1.1	-3.6	1.5	1.8
Arm fat-free mass (right)	0.0	0.1	0.2	-0.1	0.4	-0.1	-0.1	0.5
Exposure to tobacco smoke outside home	0.2	0.3	1.0	-1.0	0.1	-0.2	0.3	0.3
Comparative body size at age 10	0.4	1.0	2.7	0.5	-1.1	-0.5	-1.6	-0.9
Number of full brothers	0.3	0.4	0.9	-0.7	-0.6	0.0	-0.6	-1.0
Worry too long after embarrassment	0.4	0.7	1.7	0.8	-0.1	-1.3	0.6	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.3	-1.1	-1.1	-0.9	-0.3	-0.6
Wheeze or whistling in the chest in last year	1.0	1.7	4.6	0.2	0.6	-1.6	1.0	2.2
Number of children fathered	0.5	0.6	2.0	0.6	0.7	1.4	-0.4	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	5.8	1.3	1.9	0.1	1.8	2.4
Age at first live birth	1.7	3.0	9.2	-0.8	1.6	3.0	-1.6	-0.5
Pulse wave peak to peak time	2.2	2.6	6.6	-0.2	-1.5	0.8	-1.9	-2.6
Health satisfaction	0.6	0.7	3.2	-0.2	-0.4	-0.0	-1.8	-0.5
Shortness of breath walking on level ground	0.4	0.5	1.1	0.1	-1.0	-1.0	-0.4	-0.5
Qualifications: College or University degree	1.0	3.0	7.3	-1.0	2.2	2.7	-1.1	0.6
Eye problems/disorders: None of the above	0.3	0.3	0.8	0.9	-0.2	-0.4	0.8	0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.7	0.4	-0.0	-0.8	0.3	0.5
Emphysema/chronic bronchitis	1.2	1.3	4.9	-2.2	0.1	0.9	-0.6	-0.7
Medication for pain relief, constipation, heartburn	0.6	1.1	2.7	1.0	-1.2	-1.6	0.5	-0.1
Neck or shoulder pain in last month	0.7	1.0	3.2	0.9	-0.7	-0.4	-1.8	-0.5
Medication: Blood pressure	0.9	1.6	5.9	-2.4	0.7	0.5	1.2	0.2
Angina (self-reported)	0.6	0.8	2.3	0.5	1.1	1.5	-0.2	0.1
Migraine (self-reported)	0.5	0.7	2.8	1.7	0.4	0.3	-0.4	0.4
Medication: Ibuprofen	0.5	0.6	1.3	-0.0	1.2	1.2	0.1	0.6
Medication: Allopurinol	0.2	0.3	0.4	-0.7	-0.5	-0.2	0.5	-0.6
Medication: Omeprazole	1.2	1.4	3.3	-0.1	1.6	1.8	-0.9	0.7
Medication: Seretide 50 evohaler	0.3	0.3	0.8	0.3	0.2	-0.7	0.5	0.9
Mean time to correctly identify matches	1.4	2.7	9.7	0.7	-1.5	-3.1	-0.3	1.0
Heart disease (mother)	0.1	0.1	0.4	-0.6	0.1	0.2	0.4	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.8	-0.3	-1.3	-0.5	-0.1	-1.4
Whole body fat mass	0.4	1.5	3.0	1.2	0.3	-1.6	0.6	1.7
Leg fat mass (right)	0.5	2.0	5.2	1.4	-0.3	-2.3	0.6	1.5
Arm predicted mass (right)	0.0	0.1	0.4	-0.1	0.5	-0.1	0.0	0.6
Pulse rate, automated reading	20.6	66.4	196.0	3.7	-8.3	-14.0	7.2	1.5
Alcohol intake frequency.	0.2	0.4	0.8	0.7	-0.9	-0.2	-0.5	-0.7
Comparative height size at age 10	0.4	2.1	8.0	-0.6	1.3	2.8	-0.3	-0.7
Number of full sisters	0.4	0.5	1.8	-1.3	0.4	0.6	-0.2	-0.1
Suffer from ‘nerves’	0.7	1.1	3.6	0.9	-0.8	-1.9	0.0	0.7
Overall health rating	1.1	2.3	4.0	-0.1	-2.0	-1.8	-1.8	-1.0
Chest pain or discomfort	1.2	1.8	4.6	2.1	1.1	-0.3	0.2	1.7
Had major operations	0.4	0.5	1.1	0.3	0.5	-0.5	-1.0	1.0
Age at last live birth	0.1	0.1	0.3	-0.2	-0.3	0.1	0.5	-0.5
Family relationship satisfaction	0.9	1.1	2.6	1.1	-0.2	-1.6	0.6	1.0
Leg pain on walking	1.2	1.6	4.3	1.5	0.6	0.9	-2.1	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.0	0.1	-1.3	-1.4	0.2	-0.6
Commuting to job workplace: Car/motor vehicle	1.1	1.2	4.0	2.0	0.6	-0.1	0.9	0.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.6	-0.7	-0.8	-0.4	0.7	-0.6
Medication: Aspirin	1.0	1.4	2.3	-1.4	0.2	1.2	-1.5	-1.0
Supplements: Vitamin C	0.2	0.2	0.7	0.6	-0.0	0.0	-0.8	-0.1
Knee pain experienced in last month	0.6	0.9	1.8	0.6	0.6	1.3	-1.3	-0.5
Hypertension (Self-reported)	0.5	1.5	4.6	-1.2	-0.0	-1.0	2.1	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.3	0.3	-0.1	1.5	-1.1	-1.5
Illnesses of father: Heart disease	0.5	0.7	2.0	1.4	0.4	-0.1	1.0	0.7
Illnesses of siblings: Diabetes	0.6	0.7	3.1	-0.0	-0.4	-0.4	-1.7	0.1
Smoking status: Previous	1.9	2.8	4.8	-2.0	0.7	2.0	-2.2	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	13.3	-3.6	-1.0	1.2	-0.3	-2.5
Whole body fat-free mass	0.2	0.9	2.0	-0.4	1.4	1.3	-0.7	0.6
Leg fat-free mass (right)	0.3	1.5	3.2	-0.3	1.8	1.7	-0.8	0.8
Arm fat percentage (left)	0.3	1.3	2.3	1.4	0.2	-1.5	0.3	1.4
Average weekly red wine intake	0.6	0.9	1.5	-1.2	-0.6	0.5	-0.9	-1.1
Handedness (chirality/laterality): Left-handed	1.6	1.9	4.5	0.2	-2.1	-1.9	0.5	-1.1
Mood swings	1.1	2.0	4.2	-1.9	-0.8	0.4	-2.0	-1.4
Loneliness, isolation	1.1	1.5	4.0	1.0	-1.5	-2.0	-0.7	-0.1
Long-standing illness, disability or infirmity	0.6	0.9	3.1	0.2	0.1	0.9	-1.8	-0.5
Ever had bowel cancer screening	1.0	1.1	2.4	-0.5	-1.1	-1.5	-1.3	-0.3
Diabetes diagnosed by doctor	2.9	4.8	8.7	-2.8	0.6	2.2	-2.9	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.0	0.1	1.4	1.4	-1.1	0.6
Friendships satisfaction	1.2	1.5	3.8	1.6	-0.8	-2.0	-0.2	0.7
Qualifications: nursing, teaching	0.5	0.7	2.0	-1.4	0.6	1.1	0.0	-0.1
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.4	0.0	0.5	-0.4	-0.3
Eye problems/disorders: Cataract	0.8	0.9	3.9	-2.0	0.6	0.2	0.4	0.5
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.6	0.6	0.8	-0.2	1.3	1.3
Medication for cholesterol	0.8	1.2	3.4	0.1	1.5	1.8	-0.4	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	4.5	0.7	-1.6	-2.1	0.9	-0.3
Back pain experienced in last month	0.5	0.8	1.8	1.4	-0.1	-0.5	-1.3	0.2
Mineral and other dietary supplements	1.4	1.9	3.7	-0.9	0.6	-1.5	1.6	1.9
Breast cancer (self-reported)	0.3	0.3	0.6	0.7	-0.8	-0.5	0.2	-0.6
Asthma (self-reported)	0.1	0.2	0.5	-0.4	0.6	0.1	0.3	0.7
Osteoporosis (self-reported)	0.9	1.1	2.7	-0.4	-1.5	-1.6	0.2	-0.6
Osteoarthritis (self-reported)	1.2	1.6	4.2	1.5	-0.0	1.0	-2.1	-0.7
Medication: Aspirin	0.6	0.8	2.0	-0.9	-0.0	0.7	-1.4	-0.8
Medication: Gliclazide	1.0	1.1	3.4	-1.3	-0.4	0.1	-1.8	-0.7
Illnesses of father: None of the above (group 1)	0.3	0.3	1.6	1.3	0.1	0.3	-0.2	-0.1
Smoking status: Current	1.0	1.6	5.0	0.6	-1.0	-2.2	1.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.2	0.2	-1.5	-0.4	-0.3	-1.4
Whole body water mass	0.2	0.9	1.9	-0.4	1.4	1.2	-0.8	0.6
Leg predicted mass (right)	0.3	1.5	3.5	-0.3	1.9	1.7	-0.8	0.9
Arm fat mass (left)	0.2	0.9	1.9	1.0	0.0	-1.4	0.2	1.1
Number of self-reported non-cancer illnesses	0.7	1.2	3.7	-0.3	-0.3	0.9	-1.9	-1.1
Average weekly champagne plus white wine intake	2.0	2.8	6.2	-0.6	2.5	2.5	0.3	1.1
Miserableness	0.9	1.6	3.4	-0.5	-1.7	-1.9	-1.0	-0.6
Guilty feelings	0.8	1.2	3.1	0.7	-0.2	-1.8	0.3	1.5
Wears glasses or contact lenses	0.1	0.2	0.3	0.6	-0.1	-0.4	0.3	0.5
Ever taken oral contraceptive pill	1.4	1.6	4.2	-2.1	0.4	1.3	-1.3	-0.4
Hearing aid user	1.2	1.3	3.3	1.8	-0.7	-1.5	-0.8	0.3
Mother’s age at death	0.7	0.9	2.5	0.5	1.0	1.6	-0.7	0.0
Financial situation satisfaction	0.8	1.0	2.2	-0.2	-1.5	-0.8	0.6	-1.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.0	-0.1	0.4	1.4	-0.2	-0.8
Commuting to job workplace: Public transport	0.2	0.3	0.6	0.5	0.7	0.8	-0.1	0.3
Eye problems/disorders: Glaucoma	0.9	1.1	2.5	1.6	0.3	-0.9	0.1	1.4
Medication: Blood pressure	0.2	0.4	1.3	0.3	-0.5	-1.1	0.4	0.4
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.3	1.5	-0.0	0.7	-1.0	-0.3
Supplements: Fish oil (including cod liver oil)	3.2	4.2	11.7	-0.1	-2.0	1.0	-2.0	-3.4
High cholesterol (Self-reported)	1.0	1.7	3.8	1.9	-0.9	-1.6	1.1	0.3
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.6	-0.1	-0.0	0.6	-0.1
Medication: Paracetamol	1.0	1.5	3.1	1.5	1.3	-0.2	0.6	1.8
Medication: Lisinopril	1.5	1.9	5.5	-2.3	1.3	0.9	0.7	1.0
Medication: Atorvastatin	1.7	2.1	4.1	0.8	-1.5	-2.0	1.8	-0.4
Illnesses of father: High blood pressure	0.5	0.6	2.3	-1.5	-0.6	-0.5	-0.1	-0.3
Alcohol drinker status: Never	0.7	0.8	2.8	0.7	0.8	1.7	0.3	-0.3
Ever smoked	1.2	2.1	6.5	-2.5	0.0	1.0	-1.3	-1.1
Basal metabolic rate	0.1	0.6	1.3	-0.2	1.2	0.8	-0.5	0.7
Leg fat percentage (left)	1.3	4.6	15.0	1.4	-1.6	-3.9	1.4	1.3
Arm fat-free mass (left)	0.0	0.1	0.2	0.1	0.2	-0.2	-0.3	0.4
Number of operations (self-reported)	1.8	2.7	9.0	0.1	1.5	1.1	-3.0	1.1
Average weekly beer plus cider intake	1.0	1.4	5.3	-0.5	-0.2	-1.1	2.3	0.5
Irritability	0.2	0.3	0.7	-0.4	0.1	-0.4	-0.8	0.6
Risk taking	0.8	1.2	2.4	-1.1	0.2	-1.5	-0.4	1.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	0.1	-0.5	-0.7	0.5	-0.0
Fractured/broken bones in last 5 years	0.6	0.8	1.7	1.3	-0.9	-1.0	-0.7	-0.4
Age started oral contraceptive pill	0.9	1.1	2.4	-0.5	-1.5	-0.9	1.1	-1.0
Diastolic blood pressure, automated reading	4.3	13.5	26.8	2.3	-1.0	-5.0	5.2	3.1
Ever depressed for a whole week	0.4	0.5	1.0	-0.7	0.3	0.8	-1.0	-0.4
Unable to work because of sickness or disability	0.2	0.3	0.7	0.4	-0.7	-0.8	-0.6	-0.1
Commuting to job workplace: Cycle	1.0	1.2	2.1	-1.1	-1.1	-0.1	-1.5	-1.3
Myopia	0.3	0.4	1.0	-1.0	-0.1	0.1	-1.0	0.0
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.8	1.3	0.1	0.7	-1.7	-0.4
Cholesterol lowering medication	3.1	4.5	12.4	0.2	-2.8	-3.5	1.3	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.8	-0.1	1.4	1.7	-0.8	0.4
Pain experienced in last month	0.2	0.4	0.9	-0.8	0.5	0.2	0.9	0.5
Supplements: Calcium	0.4	0.5	0.8	-0.3	-0.9	-0.5	-0.9	-0.7
Basal cell carcinoma (self-reported)	0.3	0.4	1.8	-0.1	0.2	0.3	1.3	0.0
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.5	-0.4	1.2	1.6	-0.2	0.1
Deep venous thrombosis (DVT) (self-reported)	4.2	5.4	16.3	-1.6	-0.1	2.1	-4.0	-2.0
Heart disease (siblings)	0.6	0.7	2.0	-0.9	-0.3	-0.8	1.4	0.2
Alcohol drinker status: Previous	0.8	1.0	2.3	-0.4	-1.5	-0.6	-0.5	-1.3
Pack years of smoking	0.1	0.1	0.3	-0.6	0.3	-0.1	0.0	0.3
Impedance of whole body	0.3	1.5	4.9	-1.4	0.4	-0.1	2.2	0.7
Leg fat mass (left)	0.5	1.9	5.8	1.2	-0.6	-2.4	0.6	1.2
Arm predicted mass (left)	0.0	0.2	0.5	0.4	0.6	0.0	-0.1	0.7