Best TWAS P=2.95e-09 · Best GWAS P=1.31e-08 conditioned to 0.59
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PSMB7 | 0.08 | 0.04 | lasso | 6 | 0.04 | 3.4e-04 | 4.6 | -5.5 | 3.5e-08 | -0.92 | 0.04 | 0.95 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | PSMB7 | 0.11 | 0.03 | lasso | 7 | 0.04 | 4.7e-03 | 5.2 | -5.3 | 1.4e-07 | -0.76 | 0.04 | 0.84 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | PSMB7 | 0.09 | 0.07 | enet | 11 | 0.06 | 2.1e-05 | -5.2 | -5.2 | 1.8e-07 | -0.68 | 0.07 | 0.93 | FALSE |
| 4 | GTEx | Colon Sigmoid | PSMB7 | 0.15 | 0.10 | lasso | 3 | 0.09 | 3.3e-04 | 5.7 | -5.8 | 8.5e-09 | -0.99 | 0.02 | 0.96 | FALSE |
| 5 | GTEx | Thyroid | NEK6 | 0.20 | 0.21 | lasso | 4 | 0.20 | 1.3e-15 | 5.6 | -5.9 | 2.9e-09 | -0.92 | 0.01 | 0.99 | TRUE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | PSMB7 | 0.06 | 0.06 | lasso | 4 | 0.04 | 3.7e-05 | 5.3 | -5.3 | 9.1e-08 | -0.85 | 0.02 | 0.97 | FALSE |