Best TWAS P=8.36e-09 · Best GWAS P=8.48e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 | GTEx | Colon Transverse | PKN3 | 0.37 | 0.35 | lasso | 3 | 0.34 | 6.2e-17 | -5.7 | -5.8 | 8.4e-09 | 1.00 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Liver | PKN3 | 0.63 | 0.52 | lasso | 4 | 0.50 | 5.1e-16 | -5.7 | -5.7 | 9.5e-09 | 1.00 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Small Intestine Terminal Ileum | PKN3 | 0.28 | 0.39 | lasso | 2 | 0.36 | 5.6e-09 | -5.7 | -5.7 | 9.8e-09 | 1.00 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Stomach | PKN3 | 0.22 | 0.26 | lasso | 2 | 0.25 | 4.4e-12 | -5.7 | -5.7 | 9.8e-09 | 1.00 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PKN3 | 0.07 | 0.03 | enet | 5 | 0.05 | 3.3e-03 | -5.7 | -5.7 | 1.3e-08 | 0.90 | 0.00 | 0.94 | FALSE |
| 1 | CommonMind | Brain Pre-frontal Cortex | C9orf114 | 0.06 | 0.02 | bslmm | 320 | 0.02 | 9.7e-04 | -5.5 | -5.2 | 1.7e-07 | 0.65 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LRRC8A | 0.05 | 0.06 | blup | 35 | 0.05 | 1.8e-04 | -5.0 | -5.2 | 1.8e-07 | 0.55 | 0.00 | 0.95 | FALSE |