[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr1:37,577,214-39,186,794

Best TWAS P=6.08e-12 · Best GWAS P=1.93e-10 conditioned to 0.943

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
44	The Cancer Genome Atlas	Lung Adenocarcinoma	INPP5B	0.04	0.02	lasso	5	0.02	2.6e-03	-6.4	6.9	6.1e-12	-0.93	0.00	0.98	TRUE
33	GTEx	Whole Blood	INPP5B	0.18	0.10	enet	9	0.12	9.2e-11	-6.4	6.7	3.0e-11	-0.92	0.00	1.00	FALSE
39	YFS	Blood	INPP5B	0.25	0.30	enet	18	0.31	6.1e-105	-6.0	6.5	6.4e-11	-0.97	0.02	0.98	FALSE
7	GTEx	Artery Aorta	INPP5B	0.21	0.13	lasso	3	0.21	5.5e-12	-6.0	6.5	6.5e-11	-0.72	0.02	0.98	FALSE
12	GTEx	Artery Tibial	C1orf122	0.07	0.00	lasso	6	0.00	4.0e-01	-6.0	-6.5	8.3e-11	0.94	0.02	0.90	FALSE
1	CommonMind	Brain Pre-frontal Cortex	INPP5B	0.26	0.15	enet	30	0.26	8.4e-31	-6.0	6.5	9.7e-11	-0.86	0.02	0.98	FALSE
22	GTEx	Esophagus Muscularis	FHL3	0.10	0.02	enet	2	0.00	4.3e-01	5.0	6.4	1.2e-10	-0.73	0.03	0.73	FALSE
24	GTEx	Esophagus Muscularis	RP11-109P14.10	0.17	0.11	lasso	6	0.13	3.6e-08	-5.6	6.4	1.3e-10	-0.78	0.03	0.97	FALSE
20	GTEx	Colon Sigmoid	RP11-109P14.10	0.31	0.27	lasso	5	0.25	2.4e-09	-6.0	6.4	1.4e-10	-0.96	0.01	0.99	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-109P14.10	0.29	0.17	enet	18	0.16	7.7e-09	-6.4	6.4	1.6e-10	-0.92	0.00	1.00	FALSE
14	GTEx	Artery Tibial	RP11-109P14.10	0.21	0.13	lasso	6	0.15	1.7e-11	-5.4	6.4	1.6e-10	-0.79	0.04	0.96	FALSE
26	GTEx	Nerve Tibial	INPP5B	0.24	0.17	lasso	6	0.20	3.5e-14	-5.6	6.4	1.6e-10	-0.78	0.10	0.90	FALSE
15	GTEx	Breast Mammary Tissue (Male)	SF3A3	0.07	0.16	lasso	1	0.03	5.7e-02	-6.4	6.4	1.9e-10	-1.00	0.01	0.83	FALSE
34	GTEx	Whole Blood	RP11-109P14.10	0.12	0.05	lasso	8	0.05	2.1e-05	-6.0	6.3	2.1e-10	-0.95	0.01	0.99	FALSE
30	GTEx	Spleen	RP11-109P14.10	0.59	0.36	lasso	5	0.45	6.2e-13	-6.0	6.3	2.6e-10	-0.88	0.00	0.99	FALSE
36	NTR	Blood	INPP5B	0.05	0.03	lasso	4	0.04	3.6e-12	-6.0	6.2	4.0e-10	-0.91	0.01	0.99	FALSE
27	GTEx	Nerve Tibial	RP11-109P14.10	0.21	0.15	lasso	4	0.16	4.1e-11	-5.6	6.2	4.1e-10	-0.87	0.05	0.95	FALSE
29	GTEx	Spleen	INPP5B	0.77	0.51	lasso	7	0.66	2.5e-22	4.3	6.1	1.0e-09	-0.84	0.01	0.99	FALSE
13	GTEx	Artery Tibial	INPP5B	0.35	0.12	lasso	6	0.25	6.0e-20	3.2	6.1	1.1e-09	-0.64	0.04	0.96	FALSE
4	GTEx	Adipose Visceral Omentum	INPP5B	0.34	0.14	lasso	4	0.25	3.7e-13	-5.6	6.1	1.2e-09	-0.75	0.11	0.89	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	INPP5B	0.31	0.32	lasso	2	0.30	1.6e-10	-6.0	6.0	2.2e-09	-0.63	0.01	0.99	FALSE
32	GTEx	Thyroid	INPP5B	0.14	0.06	lasso	4	0.09	1.0e-07	4.3	5.9	3.2e-09	-0.75	0.14	0.86	FALSE
8	GTEx	Artery Aorta	RP11-109P14.10	0.26	0.17	lasso	3	0.16	3.9e-09	-5.4	5.9	3.7e-09	-0.69	0.11	0.89	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	RP11-109P14.10	0.24	0.20	lasso	4	0.17	3.2e-06	-6.0	5.8	4.9e-09	-0.63	0.01	0.97	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	FHL3	0.06	0.01	enet	10	0.01	4.2e-04	-4.2	5.8	5.2e-09	-0.40	0.00	0.98	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	INPP5B	0.22	0.16	lasso	3	0.20	8.0e-25	4.3	5.7	1.0e-08	-0.65	0.99	0.01	FALSE
19	GTEx	Colon Sigmoid	INPP5B	0.43	0.15	lasso	6	0.31	1.2e-11	3.2	5.7	1.2e-08	-0.59	0.08	0.91	FALSE
2	GTEx	Adipose Subcutaneous	RP11-109P14.10	0.28	0.21	lasso	4	0.22	6.0e-18	4.3	5.7	1.4e-08	-0.78	0.95	0.05	FALSE
40	YFS	Blood	SF3A3	0.50	0.29	enet	44	0.44	3.2e-162	4.9	5.6	1.9e-08	-0.53	0.88	0.11	FALSE
31	GTEx	Stomach	INPP5B	0.20	0.04	lasso	4	0.04	3.6e-03	4.1	5.5	2.9e-08	-0.85	0.01	0.97	FALSE
16	GTEx	Breast Mammary Tissue (Male)	RP11-109P14.10	0.29	0.03	enet	9	0.01	1.9e-01	4.3	5.5	3.6e-08	-0.88	0.03	0.45	FALSE
3	GTEx	Adipose Visceral Omentum	FHL3	0.10	0.02	enet	9	0.00	1.9e-01	5.0	5.5	3.8e-08	-0.73	0.06	0.78	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	FHL3	0.07	0.06	enet	8	0.06	4.9e-08	5.1	5.5	4.4e-08	-0.77	0.54	0.46	FALSE
6	GTEx	Adrenal Gland	FHL3	0.24	0.15	enet	17	0.34	7.4e-13	4.9	5.4	5.7e-08	-0.50	0.41	0.52	FALSE
25	GTEx	Nerve Tibial	UTP11L	0.11	0.00	enet	5	0.00	7.9e-01	4.9	5.4	8.1e-08	-0.72	0.03	0.74	FALSE
28	GTEx	Pancreas	FHL3	0.17	0.05	lasso	3	0.10	6.6e-05	-4.2	5.4	8.2e-08	-0.44	0.59	0.20	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	INPP5B	0.05	0.03	blup	68	0.05	6.7e-06	5.1	5.3	9.2e-08	-0.73	0.25	0.71	FALSE
35	METSIM	Adipose	INPP5B	0.31	0.33	enet	21	0.35	2.4e-54	4.3	5.3	1.1e-07	-0.78	0.99	0.01	FALSE
23	GTEx	Esophagus Muscularis	INPP5B	0.35	0.22	lasso	5	0.29	9.5e-18	3.2	5.2	1.7e-07	-0.54	0.98	0.02	FALSE
10	GTEx	Artery Coronary	RP11-109P14.10	0.26	0.10	enet	10	0.00	3.7e-01	4.9	5.2	1.9e-07	-0.67	0.07	0.87	FALSE
41	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FHL3	0.08	0.02	enet	7	0.03	1.1e-03	4.9	5.2	1.9e-07	-0.40	0.00	0.84	FALSE
9	GTEx	Artery Coronary	INPP5B	0.27	0.28	enet	5	0.18	1.4e-06	5.1	5.2	2.2e-07	-0.64	0.25	0.74	FALSE
11	GTEx	Artery Tibial	SF3A3	0.16	0.11	enet	8	0.12	1.2e-09	4.9	5.2	2.6e-07	-0.67	0.52	0.48	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	INPP5B	0.34	0.12	enet	32	0.23	7.3e-09	-4.1	5.1	3.1e-07	-0.54	0.05	0.94	FALSE