[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr1:107,418,424-109,188,382

Best TWAS P=1.45e-50 · Best GWAS P=7.7e-51 conditioned to 1

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Thyroid	VAV3	0.36	0.27	lasso	5	0.29	2.7e-22	15.0	15.0	1.5e-50	1.00	0.00	1.00	TRUE
2	GTEx	Lung	VAV3	0.25	0.23	lasso	2	0.23	2.4e-17	13.7	13.6	3.4e-42	0.90	0.98	0.02	FALSE
5	NTR	Blood	VAV3	0.03	0.01	lasso	4	0.01	3.6e-03	13.7	13.2	6.7e-40	0.82	0.10	0.72	FALSE
6	The Cancer Genome Atlas	Thyroid Carcinoma	VAV3	0.09	0.02	enet	13	0.05	1.3e-05	13.9	12.7	6.6e-37	0.87	0.01	0.99	FALSE
3	GTEx	Nerve Tibial	VAV3	0.20	0.07	lasso	5	0.09	8.8e-07	9.9	9.3	1.5e-20	0.77	0.13	0.86	FALSE
1	CommonMind	Brain Pre-frontal Cortex	VAV3	0.09	0.03	enet	24	0.05	1.1e-06	-2.3	5.2	2.0e-07	0.36	0.34	0.31	FALSE