[Hub]/) : Traits : Hypothyroidism (self reported) :

chr1:113,236,087-115,222,434

Best TWAS P=7.85e-81 · Best GWAS P=9.66e-176 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex MAGI3 0.06 0.00 blup 554 0.03 1.9e-04 6.67 -10.1 8.5e-24 -0.33 0.74 0.01 FALSE
2 CommonMind Brain Pre-frontal Cortex PHTF1 0.07 0.06 blup 517 0.05 1.2e-06 14.94 -10.9 8.9e-28 -0.32 0.99 0.00 FALSE
3 CommonMind Brain Pre-frontal Cortex PTPN22 0.09 0.11 lasso 2 0.12 2.7e-14 13.84 9.5 1.4e-21 0.19 1.00 0.00 FALSE
4 CommonMind Brain Pre-frontal Cortex RSBN1 0.05 0.02 enet 6 0.02 1.3e-03 5.27 5.9 3.2e-09 0.16 0.09 0.03 TRUE
5 GTEx Artery Aorta RP4-730K3.3 0.14 0.00 lasso 7 0.00 7.0e-01 -0.14 5.9 4.2e-09 0.24 0.10 0.07 FALSE
6 GTEx Artery Tibial AP4B1 0.09 0.13 lasso 1 0.13 4.0e-10 -8.85 8.8 8.9e-19 0.14 1.00 0.00 FALSE
7 GTEx Artery Tibial HIPK1 0.13 0.00 enet 39 0.00 1.3e-01 -5.78 8.5 1.8e-17 0.16 0.04 0.40 TRUE
8 GTEx Artery Tibial AP4B1-AS1 0.14 0.13 lasso 2 0.12 4.9e-10 -8.85 8.9 5.9e-19 0.14 1.00 0.00 FALSE
9 GTEx Brain Cerebellar Hemisphere AP4B1 0.29 0.22 lasso 5 0.14 1.8e-04 -9.48 9.2 4.3e-20 0.14 0.26 0.04 FALSE
10 GTEx Breast Mammary Tissue DCLRE1B 0.19 0.02 lasso 5 0.03 9.1e-03 14.98 -15.8 1.5e-56 -0.39 0.27 0.37 FALSE
11 GTEx Cells Transformed fibroblasts OLFML3 0.12 0.00 enet 23 0.00 3.0e-01 -6.42 -10.1 4.1e-24 -0.39 0.04 0.49 FALSE
12 GTEx Cells Transformed fibroblasts PHTF1 0.22 0.09 lasso 5 0.19 2.2e-14 16.93 -10.6 2.8e-26 -0.47 1.00 0.00 FALSE
13 GTEx Cells Transformed fibroblasts DCLRE1B 0.06 0.04 lasso 5 0.02 1.5e-02 10.77 -8.4 6.0e-17 -0.33 0.36 0.02 TRUE
14 GTEx Cells Transformed fibroblasts AP4B1-AS1 0.12 0.09 lasso 6 0.10 4.1e-08 15.01 -11.3 1.1e-29 -0.27 0.99 0.00 FALSE
15 GTEx Colon Transverse PTPN22 0.19 0.16 lasso 5 0.21 2.5e-10 13.84 10.8 3.2e-27 0.24 1.00 0.00 FALSE
16 GTEx Esophagus Gastroesophageal Junction OLFML3 0.34 0.02 enet 68 0.07 1.5e-03 -4.66 6.2 4.2e-10 0.27 0.14 0.06 TRUE
17 GTEx Esophagus Gastroesophageal Junction AP4B1 0.13 0.00 lasso 4 0.01 2.0e-01 -4.72 -12.8 1.2e-37 -0.47 0.10 0.19 TRUE
18 GTEx Muscle Skeletal HIPK1 0.07 0.00 enet 23 0.02 9.5e-03 6.80 -7.6 3.2e-14 -0.27 0.23 0.07 FALSE
19 GTEx Nerve Tibial AP4B1 0.23 0.09 lasso 4 0.08 1.8e-06 -8.85 6.5 5.9e-11 0.09 0.64 0.06 FALSE
20 GTEx Nerve Tibial AP4B1-AS1 0.17 0.09 lasso 3 0.07 8.2e-06 -8.85 8.1 6.1e-16 0.12 0.75 0.03 FALSE
21 GTEx Pancreas PTPN22 0.14 -0.01 enet 28 0.01 8.8e-02 13.84 7.0 2.5e-12 0.21 0.16 0.04 FALSE
22 GTEx Testis RSBN1 0.09 0.09 enet 6 0.09 8.9e-05 14.97 -15.0 4.1e-51 -0.37 0.51 0.08 FALSE
23 GTEx Testis AP4B1-AS1 0.21 0.19 lasso 5 0.19 5.9e-09 -9.48 9.5 1.5e-21 0.13 1.00 0.00 FALSE
24 GTEx Whole Blood AP4B1 0.10 0.08 enet 8 0.06 1.9e-06 0.75 5.3 1.4e-07 0.04 0.95 0.00 FALSE
25 METSIM Adipose MAGI3 0.04 0.01 blup 549 0.03 5.5e-05 0.61 -7.7 1.4e-14 -0.31 0.74 0.01 FALSE
26 METSIM Adipose PHTF1 0.10 0.03 blup 517 0.04 1.1e-06 1.64 -6.9 5.1e-12 -0.36 0.83 0.09 TRUE
27 ROSMAP Brain Pre-frontal Cortex OLFML3 0.10 0.02 enet 27 0.04 9.7e-06 14.10 -12.4 2.0e-35 -0.35 0.86 0.05 FALSE
28 ROSMAP Brain Pre-frontal Cortex DCLRE1B 0.08 0.04 enet 14 0.05 2.6e-07 17.97 -17.4 6.4e-68 -0.50 0.97 0.02 TRUE
29 YFS Blood DCLRE1B 0.23 0.35 lasso 7 0.34 1.6e-117 6.03 5.5 3.1e-08 0.14 1.00 0.00 FALSE
30 YFS Blood PTPN22 0.17 0.02 bslmm 497 0.10 3.8e-30 0.78 8.6 8.8e-18 0.25 1.00 0.00 FALSE
31 The Cancer Genome Atlas Breast Invasive Carcinoma DCLRE1B 0.02 0.00 blup 39 0.01 5.2e-03 14.98 -17.3 3.5e-67 -0.47 0.01 0.45 FALSE
32 The Cancer Genome Atlas Breast Invasive Carcinoma PHTF1 0.05 0.02 enet 7 0.03 3.1e-07 16.93 -10.8 4.1e-27 -0.48 0.22 0.63 TRUE
33 The Cancer Genome Atlas Breast Invasive Carcinoma PTPN22 0.02 0.01 blup 67 0.01 9.6e-03 17.82 15.5 4.3e-54 0.57 0.11 0.37 FALSE
34 The Cancer Genome Atlas Esophageal Carcinoma DCLRE1B 0.13 0.02 blup 39 0.08 1.8e-03 -5.92 -14.8 1.4e-49 -0.46 0.01 0.54 FALSE
35 The Cancer Genome Atlas Glioblastoma Multiforme DCLRE1B 0.20 -0.01 blup 39 0.04 3.0e-02 17.97 -16.3 4.8e-60 -0.54 0.00 0.52 FALSE
36 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma BCL2L15 0.09 0.00 blup 42 0.04 1.1e-02 13.84 14.7 5.5e-49 0.37 0.02 0.05 TRUE
37 The Cancer Genome Atlas Prostate Adenocarcinoma PHTF1 0.08 0.03 blup 62 0.05 2.1e-06 15.32 -8.0 1.2e-15 -0.39 0.75 0.01 FALSE
38 The Cancer Genome Atlas Thyroid Carcinoma DCLRE1B 0.06 0.04 enet 11 0.04 4.3e-05 17.82 -19.0 7.8e-81 -0.58 0.01 0.99 TRUE