Best TWAS P=7.85e-81 · Best GWAS P=9.66e-176 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MAGI3 | 0.06 | 0.00 | blup | 554 | 0.03 | 1.9e-04 | 6.67 | -10.1 | 8.5e-24 | -0.33 | 0.74 | 0.01 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PHTF1 | 0.07 | 0.06 | blup | 517 | 0.05 | 1.2e-06 | 14.94 | -10.9 | 8.9e-28 | -0.32 | 0.99 | 0.00 | FALSE |
| 3 | CommonMind | Brain Pre-frontal Cortex | PTPN22 | 0.09 | 0.11 | lasso | 2 | 0.12 | 2.7e-14 | 13.84 | 9.5 | 1.4e-21 | 0.19 | 1.00 | 0.00 | FALSE |
| 4 | CommonMind | Brain Pre-frontal Cortex | RSBN1 | 0.05 | 0.02 | enet | 6 | 0.02 | 1.3e-03 | 5.27 | 5.9 | 3.2e-09 | 0.16 | 0.09 | 0.03 | TRUE |
| 5 | GTEx | Artery Aorta | RP4-730K3.3 | 0.14 | 0.00 | lasso | 7 | 0.00 | 7.0e-01 | -0.14 | 5.9 | 4.2e-09 | 0.24 | 0.10 | 0.07 | FALSE |
| 6 | GTEx | Artery Tibial | AP4B1 | 0.09 | 0.13 | lasso | 1 | 0.13 | 4.0e-10 | -8.85 | 8.8 | 8.9e-19 | 0.14 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Artery Tibial | HIPK1 | 0.13 | 0.00 | enet | 39 | 0.00 | 1.3e-01 | -5.78 | 8.5 | 1.8e-17 | 0.16 | 0.04 | 0.40 | TRUE |
| 8 | GTEx | Artery Tibial | AP4B1-AS1 | 0.14 | 0.13 | lasso | 2 | 0.12 | 4.9e-10 | -8.85 | 8.9 | 5.9e-19 | 0.14 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Brain Cerebellar Hemisphere | AP4B1 | 0.29 | 0.22 | lasso | 5 | 0.14 | 1.8e-04 | -9.48 | 9.2 | 4.3e-20 | 0.14 | 0.26 | 0.04 | FALSE |
| 10 | GTEx | Breast Mammary Tissue | DCLRE1B | 0.19 | 0.02 | lasso | 5 | 0.03 | 9.1e-03 | 14.98 | -15.8 | 1.5e-56 | -0.39 | 0.27 | 0.37 | FALSE |
| 11 | GTEx | Cells Transformed fibroblasts | OLFML3 | 0.12 | 0.00 | enet | 23 | 0.00 | 3.0e-01 | -6.42 | -10.1 | 4.1e-24 | -0.39 | 0.04 | 0.49 | FALSE |
| 12 | GTEx | Cells Transformed fibroblasts | PHTF1 | 0.22 | 0.09 | lasso | 5 | 0.19 | 2.2e-14 | 16.93 | -10.6 | 2.8e-26 | -0.47 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Cells Transformed fibroblasts | DCLRE1B | 0.06 | 0.04 | lasso | 5 | 0.02 | 1.5e-02 | 10.77 | -8.4 | 6.0e-17 | -0.33 | 0.36 | 0.02 | TRUE |
| 14 | GTEx | Cells Transformed fibroblasts | AP4B1-AS1 | 0.12 | 0.09 | lasso | 6 | 0.10 | 4.1e-08 | 15.01 | -11.3 | 1.1e-29 | -0.27 | 0.99 | 0.00 | FALSE |
| 15 | GTEx | Colon Transverse | PTPN22 | 0.19 | 0.16 | lasso | 5 | 0.21 | 2.5e-10 | 13.84 | 10.8 | 3.2e-27 | 0.24 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Esophagus Gastroesophageal Junction | OLFML3 | 0.34 | 0.02 | enet | 68 | 0.07 | 1.5e-03 | -4.66 | 6.2 | 4.2e-10 | 0.27 | 0.14 | 0.06 | TRUE |
| 17 | GTEx | Esophagus Gastroesophageal Junction | AP4B1 | 0.13 | 0.00 | lasso | 4 | 0.01 | 2.0e-01 | -4.72 | -12.8 | 1.2e-37 | -0.47 | 0.10 | 0.19 | TRUE |
| 18 | GTEx | Muscle Skeletal | HIPK1 | 0.07 | 0.00 | enet | 23 | 0.02 | 9.5e-03 | 6.80 | -7.6 | 3.2e-14 | -0.27 | 0.23 | 0.07 | FALSE |
| 19 | GTEx | Nerve Tibial | AP4B1 | 0.23 | 0.09 | lasso | 4 | 0.08 | 1.8e-06 | -8.85 | 6.5 | 5.9e-11 | 0.09 | 0.64 | 0.06 | FALSE |
| 20 | GTEx | Nerve Tibial | AP4B1-AS1 | 0.17 | 0.09 | lasso | 3 | 0.07 | 8.2e-06 | -8.85 | 8.1 | 6.1e-16 | 0.12 | 0.75 | 0.03 | FALSE |
| 21 | GTEx | Pancreas | PTPN22 | 0.14 | -0.01 | enet | 28 | 0.01 | 8.8e-02 | 13.84 | 7.0 | 2.5e-12 | 0.21 | 0.16 | 0.04 | FALSE |
| 22 | GTEx | Testis | RSBN1 | 0.09 | 0.09 | enet | 6 | 0.09 | 8.9e-05 | 14.97 | -15.0 | 4.1e-51 | -0.37 | 0.51 | 0.08 | FALSE |
| 23 | GTEx | Testis | AP4B1-AS1 | 0.21 | 0.19 | lasso | 5 | 0.19 | 5.9e-09 | -9.48 | 9.5 | 1.5e-21 | 0.13 | 1.00 | 0.00 | FALSE |
| 24 | GTEx | Whole Blood | AP4B1 | 0.10 | 0.08 | enet | 8 | 0.06 | 1.9e-06 | 0.75 | 5.3 | 1.4e-07 | 0.04 | 0.95 | 0.00 | FALSE |
| 25 | METSIM | Adipose | MAGI3 | 0.04 | 0.01 | blup | 549 | 0.03 | 5.5e-05 | 0.61 | -7.7 | 1.4e-14 | -0.31 | 0.74 | 0.01 | FALSE |
| 26 | METSIM | Adipose | PHTF1 | 0.10 | 0.03 | blup | 517 | 0.04 | 1.1e-06 | 1.64 | -6.9 | 5.1e-12 | -0.36 | 0.83 | 0.09 | TRUE |
| 27 | ROSMAP | Brain Pre-frontal Cortex | OLFML3 | 0.10 | 0.02 | enet | 27 | 0.04 | 9.7e-06 | 14.10 | -12.4 | 2.0e-35 | -0.35 | 0.86 | 0.05 | FALSE |
| 28 | ROSMAP | Brain Pre-frontal Cortex | DCLRE1B | 0.08 | 0.04 | enet | 14 | 0.05 | 2.6e-07 | 17.97 | -17.4 | 6.4e-68 | -0.50 | 0.97 | 0.02 | TRUE |
| 29 | YFS | Blood | DCLRE1B | 0.23 | 0.35 | lasso | 7 | 0.34 | 1.6e-117 | 6.03 | 5.5 | 3.1e-08 | 0.14 | 1.00 | 0.00 | FALSE |
| 30 | YFS | Blood | PTPN22 | 0.17 | 0.02 | bslmm | 497 | 0.10 | 3.8e-30 | 0.78 | 8.6 | 8.8e-18 | 0.25 | 1.00 | 0.00 | FALSE |
| 31 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DCLRE1B | 0.02 | 0.00 | blup | 39 | 0.01 | 5.2e-03 | 14.98 | -17.3 | 3.5e-67 | -0.47 | 0.01 | 0.45 | FALSE |
| 32 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PHTF1 | 0.05 | 0.02 | enet | 7 | 0.03 | 3.1e-07 | 16.93 | -10.8 | 4.1e-27 | -0.48 | 0.22 | 0.63 | TRUE |
| 33 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PTPN22 | 0.02 | 0.01 | blup | 67 | 0.01 | 9.6e-03 | 17.82 | 15.5 | 4.3e-54 | 0.57 | 0.11 | 0.37 | FALSE |
| 34 | The Cancer Genome Atlas | Esophageal Carcinoma | DCLRE1B | 0.13 | 0.02 | blup | 39 | 0.08 | 1.8e-03 | -5.92 | -14.8 | 1.4e-49 | -0.46 | 0.01 | 0.54 | FALSE |
| 35 | The Cancer Genome Atlas | Glioblastoma Multiforme | DCLRE1B | 0.20 | -0.01 | blup | 39 | 0.04 | 3.0e-02 | 17.97 | -16.3 | 4.8e-60 | -0.54 | 0.00 | 0.52 | FALSE |
| 36 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | BCL2L15 | 0.09 | 0.00 | blup | 42 | 0.04 | 1.1e-02 | 13.84 | 14.7 | 5.5e-49 | 0.37 | 0.02 | 0.05 | TRUE |
| 37 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PHTF1 | 0.08 | 0.03 | blup | 62 | 0.05 | 2.1e-06 | 15.32 | -8.0 | 1.2e-15 | -0.39 | 0.75 | 0.01 | FALSE |
| 38 | The Cancer Genome Atlas | Thyroid Carcinoma | DCLRE1B | 0.06 | 0.04 | enet | 11 | 0.04 | 4.3e-05 | 17.82 | -19.0 | 7.8e-81 | -0.58 | 0.01 | 0.99 | TRUE |