[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr1:113,236,087-115,222,434

Best TWAS P=7.85e-81 · Best GWAS P=9.66e-176 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
38	The Cancer Genome Atlas	Thyroid Carcinoma	DCLRE1B	0.06	0.04	enet	11	0.04	4.3e-05	17.82	-19.0	7.8e-81	-0.58	0.01	0.99	TRUE
28	ROSMAP	Brain Pre-frontal Cortex	DCLRE1B	0.08	0.04	enet	14	0.05	2.6e-07	17.97	-17.4	6.4e-68	-0.50	0.97	0.02	TRUE
36	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	BCL2L15	0.09	0.00	blup	42	0.04	1.1e-02	13.84	14.7	5.5e-49	0.37	0.02	0.05	TRUE
17	GTEx	Esophagus Gastroesophageal Junction	AP4B1	0.13	0.00	lasso	4	0.01	2.0e-01	-4.72	-12.8	1.2e-37	-0.47	0.10	0.19	TRUE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	PHTF1	0.05	0.02	enet	7	0.03	3.1e-07	16.93	-10.8	4.1e-27	-0.48	0.22	0.63	TRUE
7	GTEx	Artery Tibial	HIPK1	0.13	0.00	enet	39	0.00	1.3e-01	-5.78	8.5	1.8e-17	0.16	0.04	0.40	TRUE
13	GTEx	Cells Transformed fibroblasts	DCLRE1B	0.06	0.04	lasso	5	0.02	1.5e-02	10.77	-8.4	6.0e-17	-0.33	0.36	0.02	TRUE
26	METSIM	Adipose	PHTF1	0.10	0.03	blup	517	0.04	1.1e-06	1.64	-6.9	5.1e-12	-0.36	0.83	0.09	TRUE
16	GTEx	Esophagus Gastroesophageal Junction	OLFML3	0.34	0.02	enet	68	0.07	1.5e-03	-4.66	6.2	4.2e-10	0.27	0.14	0.06	TRUE
4	CommonMind	Brain Pre-frontal Cortex	RSBN1	0.05	0.02	enet	6	0.02	1.3e-03	5.27	5.9	3.2e-09	0.16	0.09	0.03	TRUE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	DCLRE1B	0.02	0.00	blup	39	0.01	5.2e-03	14.98	-17.3	3.5e-67	-0.47	0.01	0.45	FALSE
35	The Cancer Genome Atlas	Glioblastoma Multiforme	DCLRE1B	0.20	-0.01	blup	39	0.04	3.0e-02	17.97	-16.3	4.8e-60	-0.54	0.00	0.52	FALSE
10	GTEx	Breast Mammary Tissue	DCLRE1B	0.19	0.02	lasso	5	0.03	9.1e-03	14.98	-15.8	1.5e-56	-0.39	0.27	0.37	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	PTPN22	0.02	0.01	blup	67	0.01	9.6e-03	17.82	15.5	4.3e-54	0.57	0.11	0.37	FALSE
22	GTEx	Testis	RSBN1	0.09	0.09	enet	6	0.09	8.9e-05	14.97	-15.0	4.1e-51	-0.37	0.51	0.08	FALSE
34	The Cancer Genome Atlas	Esophageal Carcinoma	DCLRE1B	0.13	0.02	blup	39	0.08	1.8e-03	-5.92	-14.8	1.4e-49	-0.46	0.01	0.54	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	OLFML3	0.10	0.02	enet	27	0.04	9.7e-06	14.10	-12.4	2.0e-35	-0.35	0.86	0.05	FALSE
14	GTEx	Cells Transformed fibroblasts	AP4B1-AS1	0.12	0.09	lasso	6	0.10	4.1e-08	15.01	-11.3	1.1e-29	-0.27	0.99	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PHTF1	0.07	0.06	blup	517	0.05	1.2e-06	14.94	-10.9	8.9e-28	-0.32	0.99	0.00	FALSE
15	GTEx	Colon Transverse	PTPN22	0.19	0.16	lasso	5	0.21	2.5e-10	13.84	10.8	3.2e-27	0.24	1.00	0.00	FALSE
12	GTEx	Cells Transformed fibroblasts	PHTF1	0.22	0.09	lasso	5	0.19	2.2e-14	16.93	-10.6	2.8e-26	-0.47	1.00	0.00	FALSE
11	GTEx	Cells Transformed fibroblasts	OLFML3	0.12	0.00	enet	23	0.00	3.0e-01	-6.42	-10.1	4.1e-24	-0.39	0.04	0.49	FALSE
1	CommonMind	Brain Pre-frontal Cortex	MAGI3	0.06	0.00	blup	554	0.03	1.9e-04	6.67	-10.1	8.5e-24	-0.33	0.74	0.01	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PTPN22	0.09	0.11	lasso	2	0.12	2.7e-14	13.84	9.5	1.4e-21	0.19	1.00	0.00	FALSE
23	GTEx	Testis	AP4B1-AS1	0.21	0.19	lasso	5	0.19	5.9e-09	-9.48	9.5	1.5e-21	0.13	1.00	0.00	FALSE
9	GTEx	Brain Cerebellar Hemisphere	AP4B1	0.29	0.22	lasso	5	0.14	1.8e-04	-9.48	9.2	4.3e-20	0.14	0.26	0.04	FALSE
8	GTEx	Artery Tibial	AP4B1-AS1	0.14	0.13	lasso	2	0.12	4.9e-10	-8.85	8.9	5.9e-19	0.14	1.00	0.00	FALSE
6	GTEx	Artery Tibial	AP4B1	0.09	0.13	lasso	1	0.13	4.0e-10	-8.85	8.8	8.9e-19	0.14	1.00	0.00	FALSE
30	YFS	Blood	PTPN22	0.17	0.02	bslmm	497	0.10	3.8e-30	0.78	8.6	8.8e-18	0.25	1.00	0.00	FALSE
20	GTEx	Nerve Tibial	AP4B1-AS1	0.17	0.09	lasso	3	0.07	8.2e-06	-8.85	8.1	6.1e-16	0.12	0.75	0.03	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	PHTF1	0.08	0.03	blup	62	0.05	2.1e-06	15.32	-8.0	1.2e-15	-0.39	0.75	0.01	FALSE
25	METSIM	Adipose	MAGI3	0.04	0.01	blup	549	0.03	5.5e-05	0.61	-7.7	1.4e-14	-0.31	0.74	0.01	FALSE
18	GTEx	Muscle Skeletal	HIPK1	0.07	0.00	enet	23	0.02	9.5e-03	6.80	-7.6	3.2e-14	-0.27	0.23	0.07	FALSE
21	GTEx	Pancreas	PTPN22	0.14	-0.01	enet	28	0.01	8.8e-02	13.84	7.0	2.5e-12	0.21	0.16	0.04	FALSE
19	GTEx	Nerve Tibial	AP4B1	0.23	0.09	lasso	4	0.08	1.8e-06	-8.85	6.5	5.9e-11	0.09	0.64	0.06	FALSE
5	GTEx	Artery Aorta	RP4-730K3.3	0.14	0.00	lasso	7	0.00	7.0e-01	-0.14	5.9	4.2e-09	0.24	0.10	0.07	FALSE
29	YFS	Blood	DCLRE1B	0.23	0.35	lasso	7	0.34	1.6e-117	6.03	5.5	3.1e-08	0.14	1.00	0.00	FALSE
24	GTEx	Whole Blood	AP4B1	0.10	0.08	enet	8	0.06	1.9e-06	0.75	5.3	1.4e-07	0.04	0.95	0.00	FALSE