[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr17:44,788,310-46,704,536

Best TWAS P=6.72e-16 · Best GWAS P=7.37e-16 conditioned to 0.0428

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TBKBP1	0.03	0.00	blup	415	0.01	5.4e-02	-5.3	6.0	2.5e-09	0.51	0.24	0.11	TRUE
2	GTEx	Adipose Subcutaneous	MRPL10	0.19	0.10	lasso	6	0.13	1.7e-10	3.5	-5.5	4.7e-08	-0.44	0.93	0.06	TRUE
3	GTEx	Breast Mammary Tissue (Male)	EFCAB13	0.11	0.09	lasso	1	-0.01	5.0e-01	-5.2	-5.2	2.4e-07	-0.47	0.05	0.17	FALSE
4	GTEx	Heart Atrial Appendage	TBKBP1	0.09	0.02	lasso	5	0.01	8.8e-02	3.6	5.3	8.6e-08	0.37	0.32	0.05	FALSE
5	GTEx	Heart Atrial Appendage	RP11-6N17.3	0.16	0.00	enet	27	0.01	1.4e-01	-3.4	-5.2	1.7e-07	-0.22	0.04	0.14	TRUE
6	GTEx	Nerve Tibial	RP11-580I16.2	0.06	0.08	enet	10	0.06	3.2e-05	-4.4	5.7	1.0e-08	0.44	0.84	0.08	FALSE
7	GTEx	Ovary	TBKBP1	0.19	0.08	enet	16	0.10	2.5e-03	4.2	5.4	8.3e-08	0.48	0.31	0.10	FALSE
8	GTEx	Uterus	EFCAB13	0.41	0.03	lasso	9	0.28	1.7e-06	5.8	-6.9	4.0e-12	-0.48	0.03	0.54	TRUE
9	METSIM	Adipose	NPEPPS	0.04	0.02	lasso	6	0.03	1.4e-05	7.2	8.1	6.7e-16	0.76	0.02	0.98	TRUE
10	METSIM	Adipose	TBKBP1	0.08	0.10	lasso	4	0.10	2.1e-14	4.3	5.3	1.3e-07	0.47	0.96	0.04	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	TBKBP1	0.02	0.03	lasso	2	0.03	3.0e-06	-5.2	5.2	2.2e-07	0.48	0.89	0.05	TRUE
12	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TBKBP1	0.12	0.09	blup	46	0.08	8.4e-05	4.3	6.2	4.1e-10	0.61	0.28	0.25	FALSE
13	The Cancer Genome Atlas	Colon Adenocarcinoma	TBKBP1	0.09	0.06	blup	46	0.09	7.8e-06	4.2	6.1	8.9e-10	0.61	0.57	0.21	TRUE
14	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C17orf57	0.28	0.16	lasso	6	0.15	1.4e-07	-4.4	-5.9	4.3e-09	-0.45	0.48	0.47	TRUE
15	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TBKBP1	0.05	0.04	enet	11	0.05	2.9e-06	4.3	5.7	1.6e-08	0.47	0.40	0.58	TRUE
16	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TBKBP1	0.03	0.04	blup	47	0.04	5.3e-04	-4.4	5.3	9.0e-08	0.51	0.35	0.11	FALSE
17	The Cancer Genome Atlas	Prostate Adenocarcinoma	TBKBP1	0.06	0.07	blup	47	0.08	1.3e-08	3.2	5.6	2.2e-08	0.54	0.41	0.59	FALSE
18	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TBKBP1	0.11	0.04	blup	45	0.03	5.3e-02	-5.2	5.8	4.9e-09	0.58	0.06	0.18	FALSE