Best TWAS P=1.84e-12 · Best GWAS P=1.86e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RAB5C | 0.21 | 0.18 | bslmm | 326 | 0.18 | 8.1e-21 | 7.0 | 6.8 | 9.7e-12 | 0.96 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | RAB5C | 0.19 | 0.02 | lasso | 6 | 0.02 | 3.7e-02 | 4.6 | 5.8 | 8.6e-09 | 0.94 | 0.01 | 0.92 | FALSE |
| 3 | GTEx | Esophagus Muscularis | RAB5C | 0.20 | 0.12 | lasso | 6 | 0.11 | 3.1e-07 | 4.6 | 5.3 | 1.1e-07 | 0.91 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Muscle Skeletal | RAB5C | 0.10 | 0.07 | lasso | 2 | 0.06 | 3.9e-06 | 7.0 | 7.0 | 1.8e-12 | 1.00 | 0.00 | 1.00 | TRUE |
| 5 | GTEx | Nerve Tibial | RAB5C | 0.14 | 0.08 | lasso | 8 | 0.07 | 1.1e-05 | 7.0 | 6.1 | 1.2e-09 | 0.95 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Pancreas | RAB5C | 0.14 | 0.13 | lasso | 2 | 0.08 | 2.6e-04 | 7.0 | 7.0 | 3.3e-12 | 1.00 | 0.00 | 0.99 | FALSE |
| 7 | GTEx | Stomach | RAB5C | 0.15 | 0.10 | lasso | 3 | 0.10 | 2.5e-05 | 4.6 | 5.3 | 1.4e-07 | 0.90 | 0.02 | 0.98 | FALSE |
| 8 | METSIM | Adipose | PTRF | 0.03 | 0.02 | lasso | 3 | 0.01 | 3.3e-03 | 4.5 | -5.3 | 9.9e-08 | -0.60 | 0.31 | 0.62 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | HSPB9 | 0.05 | 0.05 | lasso | 2 | 0.04 | 4.7e-05 | 7.0 | 7.0 | 2.0e-12 | 1.00 | 0.00 | 1.00 | FALSE |