[Hub]/) : Traits : Hypothyroidism (self reported) :

chr17:39,589,083-41,265,776

Best TWAS P=1.84e-12 · Best GWAS P=1.86e-12 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex RAB5C 0.21 0.18 bslmm 326 0.18 8.1e-21 7.0 6.8 9.7e-12 0.96 0.00 1.00 FALSE
2 GTEx Adipose Visceral Omentum RAB5C 0.19 0.02 lasso 6 0.02 3.7e-02 4.6 5.8 8.6e-09 0.94 0.01 0.92 FALSE
3 GTEx Esophagus Muscularis RAB5C 0.20 0.12 lasso 6 0.11 3.1e-07 4.6 5.3 1.1e-07 0.91 0.01 0.99 FALSE
4 GTEx Muscle Skeletal RAB5C 0.10 0.07 lasso 2 0.06 3.9e-06 7.0 7.0 1.8e-12 1.00 0.00 1.00 TRUE
5 GTEx Nerve Tibial RAB5C 0.14 0.08 lasso 8 0.07 1.1e-05 7.0 6.1 1.2e-09 0.95 0.01 0.99 FALSE
6 GTEx Pancreas RAB5C 0.14 0.13 lasso 2 0.08 2.6e-04 7.0 7.0 3.3e-12 1.00 0.00 0.99 FALSE
7 GTEx Stomach RAB5C 0.15 0.10 lasso 3 0.10 2.5e-05 4.6 5.3 1.4e-07 0.90 0.02 0.98 FALSE
8 METSIM Adipose PTRF 0.03 0.02 lasso 3 0.01 3.3e-03 4.5 -5.3 9.9e-08 -0.60 0.31 0.62 FALSE
9 The Cancer Genome Atlas Thyroid Carcinoma HSPB9 0.05 0.05 lasso 2 0.04 4.7e-05 7.0 7.0 2.0e-12 1.00 0.00 1.00 FALSE