Best TWAS P=9.98e-13 · Best GWAS P=1.45e-23 conditioned to 4.83e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ROSMAP | Brain Pre-frontal Cortex | TICAM1 | 0.07 | 0.02 | lasso | 5 | 0.04 | 1.2e-05 | 8.7 | 7.1 | 1.0e-12 | 0.81 | 0.01 | 0.99 | TRUE |
| 2 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FEM1A | 0.06 | 0.00 | blup | 42 | 0.03 | 1.4e-04 | 8.1 | -6.3 | 3.9e-10 | -0.53 | 0.01 | 0.43 | TRUE |
| 3 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FEM1A | 0.10 | 0.10 | lasso | 3 | 0.08 | 4.6e-04 | -6.8 | -6.7 | 1.8e-11 | -0.66 | 0.03 | 0.46 | FALSE |
| 4 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FEM1A | 0.03 | 0.01 | enet | 6 | 0.02 | 5.0e-03 | -4.0 | -6.4 | 1.6e-10 | -0.73 | 0.05 | 0.36 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | TICAM1 | 0.07 | 0.04 | blup | 54 | 0.06 | 1.6e-06 | 8.1 | 6.9 | 4.6e-12 | 0.78 | 0.01 | 0.99 | FALSE |