TWAS hub - TICAM1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0710	0.0270	3.6e-03	0.027	0.019	0.033	0.027	0.029	0.00029	2.0e-03	6.0e-05	0.00028	1.4e-04
2	ROSMAP	Brain Pre-frontal Cortex	0.0697	0.0246	2.5e-03	0.016	0.019	0.029	0.024	0.037	0.00330	1.3e-03	9.7e-05	0.00043	1.2e-05
3	TCGA	Liver Hepatocellular Carcinoma	0.0970	0.0440	8.4e-03	-0.002	0.001	-0.006	NA	0.004	0.44000	3.0e-01	7.9e-01	NA	2.1e-01
4	TCGA	Thyroid Carcinoma	0.0660	0.0260	2.7e-05	0.037	0.060	0.053	NA	0.049	0.00016	1.6e-06	6.4e-06	NA	1.5e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Hypothyroidism (self reported)	13.1	30.1	50.8	4.4	7.1	1.3	6.9
Medication: Levothyroxine sodium	12.1	20.5	38.0	3.9	6.2	-0.3	5.4
Hypothyroidism/myxoedema (self-reported)	10.6	20.6	35.5	4.0	6.0	0.9	5.5
Taking other prescription medications	7.3	11.3	16.4	4.1	3.1	1.8	4.0
Eye problems/disorders: Diabetes related eye disease	4.2	4.6	6.9	1.6	1.9	2.3	2.6
Number of live births	3.7	5.3	8.6	-2.4	-2.3	2.9	-1.2
Number of incorrect matches in round	3.6	6.0	11.7	-2.0	-3.4	-1.0	-2.7
Medication: Metformin	3.5	4.9	7.2	2.7	2.2	0.7	2.6
Medication for cholesterol	3.4	5.1	8.7	-2.0	-2.7	-0.4	-2.9
Number of self-reported non-cancer illnesses	3.0	5.1	10.3	1.7	2.4	1.3	3.2
Average weekly fortified wine intake	2.9	3.4	7.7	2.8	0.7	-2.3	0.4
Overall health rating	2.9	6.2	11.8	1.8	2.9	1.0	3.4
Rheumatoid Arthritis	2.7	3.8	6.6	-2.6	1.6	-1.5	1.8
Diverticular disease/diverticulitis (self-reported)	2.6	3.1	5.2	-1.6	-2.2	-0.1	-2.3
Wheeze or whistling in the chest in last year	2.6	4.7	7.4	2.4	2.2	0.8	2.7
Basal cell carcinoma (self-reported)	2.6	3.0	6.2	-2.0	-2.5	0.7	-1.2
Time employed in main current job	2.5	2.8	5.5	2.1	0.7	-2.4	1.1
Pulse wave reflection index	2.5	3.1	4.8	-1.1	1.6	2.2	2.0
Chronotype (morning person)	2.4	5.5	9.2	3.0	2.7	-2.0	1.4
Commuting to job workplace: Walk	2.3	2.4	5.0	1.3	1.1	2.2	1.4
Tinnitus: Yes, but not now, but have in the past	2.2	2.4	5.1	-0.0	-2.3	1.7	-1.2
Medication: Amlodipine	2.2	3.1	6.1	-1.3	-2.5	1.2	-1.8
Pulse wave Arterial Stiffness index	2.1	2.4	5.4	0.2	1.9	0.9	2.3
Cholesterol lowering medication	2.1	3.1	5.2	1.7	2.0	0.3	2.3
Alcohol usually taken with meals	1.9	3.1	5.8	2.4	1.8	0.2	1.8
Medication: Ramipril	1.9	2.5	4.8	1.7	1.3	0.6	2.2
Pulse wave peak to peak time	1.9	2.2	5.2	-0.2	-1.7	-0.7	-2.3
Medication: Lansoprazole	1.8	2.1	5.2	1.1	0.6	2.3	1.2
Prospective memory result	1.8	2.2	3.9	-1.3	-2.0	-0.6	-1.7
Lung cancer (father)	1.8	2.1	3.5	-1.6	-1.3	1.9	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	3.7	1.5	1.6	1.5	1.9
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	4.6	-2.1	-1.0	1.7	-0.0
Medication: Paracetamol	1.7	2.8	4.9	-0.6	2.2	1.1	2.2
Breast cancer (self-reported)	1.7	2.0	5.1	-0.0	1.2	2.2	1.2
Average weekly beer plus cider intake	1.7	2.5	3.8	-1.9	-1.6	0.6	-1.9
Number of treatments/medications taken	1.6	2.9	5.2	2.3	1.7	0.4	1.9
Pain all over the body in last month	1.6	1.7	3.3	0.8	1.8	0.2	1.7
Noisy workplace	1.6	2.0	5.6	-0.2	0.6	2.4	1.4
Illnesses of mother	1.6	2.0	3.4	-1.8	-1.5	1.0	-1.2
Headache pain in last month	1.6	2.8	4.5	1.0	1.6	1.7	2.1
Supplements: Calcium	1.6	1.7	3.9	2.0	0.9	0.8	1.2
Medication: Atenolol	1.5	1.9	5.8	0.7	0.4	2.4	1.0
Mineral and other dietary supplements	1.5	2.0	3.7	-1.9	-1.0	-1.4	-1.2
Diabetes (father)	1.4	1.8	3.4	1.1	1.9	0.6	1.5
Exposure to tobacco smoke at home	1.4	1.6	5.3	-0.7	-0.8	2.3	-0.1
Medication: Omeprazole	1.4	1.7	2.8	-1.7	-1.1	1.7	0.1
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.8	-1.1	-1.7	0.9	-1.2
Fasting Glucose	1.3	1.6	4.0	-1.3	0.4	2.0	0.6
Medication for hormone replacement therapy	1.3	1.4	3.3	1.8	1.0	-0.2	1.2
Fed-up feelings	1.3	2.4	5.2	1.1	1.7	0.2	2.3
Serious illness, injury or assault to yourself	1.3	1.6	3.0	1.3	0.7	1.7	1.0
Hayfever/allergic rhinitis (self-reported)	1.3	1.8	5.2	0.1	0.5	2.3	1.2
High blood pressure (siblings)	1.3	1.9	3.1	1.8	-1.7	0.0	-1.3
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	5.3	-2.3	0.9	1.1	0.8
Eye problems/disorders: Glaucoma	1.3	1.5	3.4	-0.0	-1.8	0.8	-1.5
Medication: Paracetamol	1.3	2.1	3.5	-0.5	1.9	1.1	1.8
Bipolar Disorder (2018)	1.2	1.8	3.4	1.9	1.1	-1.3	1.0
Waist Hip Ratio (WHR)	1.2	5.3	9.2	2.2	2.0	1.7	3.0
Waist circumference	1.2	4.3	6.0	2.2	2.0	1.5	2.5
Pulse rate	1.2	2.0	3.1	-1.5	-1.3	-1.8	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	6.4	-2.5	-1.6	-1.3	-2.3
Long-standing illness, disability or infirmity	1.2	1.8	3.5	1.4	1.0	0.8	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	3.6	-1.6	-1.2	-1.6	-1.9
Medication: Lisinopril	1.2	1.6	3.9	0.2	1.4	-2.0	0.7
Ever used hormone-replacement therapy (HRT)	1.1	1.4	1.8	0.8	1.3	1.3	1.3
Had menopause	1.1	1.4	2.2	1.5	1.4	1.0	0.7
Had other major operations	1.1	1.4	1.9	1.3	1.4	0.9	1.1
Illnesses of siblings	1.1	1.6	2.5	-1.2	1.6	0.9	1.2
Gout (self-reported)	1.1	1.5	2.2	1.1	1.4	-0.8	1.5
Birth weight	1.1	2.4	4.7	2.0	2.2	0.0	0.9
Forced vital capacity (FVC), Best measure	1.1	3.8	5.7	-2.4	-1.5	-1.3	-2.4
Shortness of breath walking on level ground	1.1	1.3	2.8	1.0	1.1	-0.3	1.7
Leg fat mass (right)	1.1	4.2	7.2	1.9	2.4	0.4	2.7
Alcohol intake frequency.	1.1	2.5	5.2	1.1	1.5	1.3	2.3
Osteoarthritis (self-reported)	1.1	1.5	2.3	-0.2	1.5	1.5	1.2
Heart attack/myocardial infarction (self-reported)	1.1	1.5	2.1	0.9	1.4	0.9	1.4
Ulcerative Colitis	1.0	1.5	2.1	-1.3	1.5	0.1	1.5
Smoking Status	1.0	2.4	3.3	-1.4	-1.8	1.8	-1.1
Heart attack	1.0	1.3	1.9	0.8	1.4	0.9	1.3
Diabetes (self-reported)	1.0	1.5	3.2	1.8	1.2	-0.3	1.1
Father’s age at death	1.0	1.3	4.0	2.0	1.0	-0.4	0.3
Leg fat percentage (right)	1.0	3.7	6.4	1.7	2.3	0.2	2.5
Number of children fathered	1.0	1.2	2.2	-1.5	-0.6	-0.4	-1.4
Health satisfaction	1.0	1.3	3.7	0.8	0.8	0.2	1.9
Medication for pain relief, constipation, heartburn	1.0	1.6	3.4	0.2	-1.8	0.6	-1.6
Diabetes diagnosed by doctor	1.0	1.6	3.5	1.9	1.2	-0.3	1.2
Osteoporosis (self-reported)	1.0	1.2	2.3	-0.1	1.5	0.4	1.5
Illnesses of father: None of the above (group 1)	1.0	1.2	2.8	-1.7	-1.2	-0.4	-0.7
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.2	-0.3	0.1	1.5	1.5
Leg fat mass (left)	1.0	4.0	6.9	1.9	2.3	0.4	2.6
LDL Cholesterol	0.9	1.5	4.2	2.0	0.9	0.4	0.9
Sensitivity / hurt feelings	0.9	1.6	3.3	0.2	1.3	1.0	1.8
Townsend deprivation index at recruitment	0.9	1.3	3.2	-1.8	-0.6	1.3	0.2
Chronic bronchitis/emphysema (father)	0.9	1.1	4.0	-0.5	0.1	2.0	-0.4
Blood clot in the leg (DVT)	0.9	1.2	1.9	0.5	-1.4	-1.0	-1.3
Glaucoma (self-reported)	0.9	1.1	3.0	0.1	-1.2	1.7	-0.1
Emphysema/chronic bronchitis	0.9	1.0	2.2	-0.2	1.5	0.6	1.2
Number of full sisters	0.9	1.1	2.2	-1.5	-0.2	1.1	0.9
Mood swings	0.9	1.6	3.5	0.1	1.0	1.3	1.9
Medication: Blood pressure	0.9	1.8	2.8	1.0	1.6	0.9	1.7
Leg fat percentage (left)	0.9	3.2	5.8	1.6	2.0	0.2	2.4
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	1.6	0.5	-1.2	-1.1	-1.2
Alzheimer’s Disease (in father)	0.8	0.8	2.5	1.6	0.1	0.1	-0.9
Primary Biliary Cirrhosis	0.8	1.1	1.9	0.6	1.2	-0.8	1.4
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.3	-0.2	0.5	1.5	1.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.9	1.4	1.1	0.2	0.9
Past tobacco smoking	0.8	1.4	2.8	0.8	1.2	-1.7	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.4	0.9	0.7	0.8	1.9
Breastfed as a baby	0.8	1.0	2.9	0.7	0.3	-1.7	-0.5
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	3.2	-0.6	-0.4	-1.8	-0.7
Number of full brothers	0.8	1.1	2.9	0.8	-0.9	1.7	0.2
Age at first live birth	0.8	1.5	2.4	-0.1	-1.5	-1.1	-1.5
Eye problems/disorders: None of the above	0.8	0.9	1.4	0.9	1.1	-1.2	0.2
Leg pain on walking	0.8	1.0	1.4	1.1	1.0	0.3	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.5	1.2	0.7	1.0	1.0
Ever taken oral contraceptive pill	0.8	0.9	2.5	-1.6	0.6	0.3	0.8
Mother’s age at death	0.8	1.0	1.8	0.5	1.4	0.7	1.3
High cholesterol (Self-reported)	0.8	1.3	2.5	1.6	0.8	-0.8	1.2
Alzheimer’s Disease (in mother)	0.7	0.9	2.6	1.6	0.5	0.1	0.8
Type 2 Diabetes (T2D) (2018)	0.7	1.2	1.7	1.2	1.2	-0.3	1.3
Relative age of first facial hair	0.7	1.4	2.6	1.1	1.1	0.8	1.6
Hearing difficulty/problems with background noise	0.7	1.1	1.5	0.2	1.2	1.2	1.2
Hair/balding pattern: Pattern 2	0.7	0.9	1.3	-1.0	0.5	1.2	1.0
Medication: Simvastatin	0.7	1.1	2.4	1.5	0.4	-1.1	0.6
Happiness	0.7	0.9	1.4	0.8	0.5	1.1	1.2
Medication: Cholesterol lowering	0.7	1.1	2.6	1.6	-0.4	-1.3	-0.2
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.6	0.3	-1.3	0.2	-1.2
Worry too long after embarrassment	0.7	1.2	3.3	1.8	0.9	-0.1	0.8
Qualifications: College or University degree	0.7	2.1	7.1	-0.9	-0.3	-2.7	-0.7
Neck or shoulder pain in last month	0.7	1.0	2.6	1.6	0.8	-0.7	0.5
Medication: Blood pressure	0.7	1.2	2.2	-1.1	-1.5	-0.6	-0.9
Friendships satisfaction	0.7	0.9	2.0	1.4	0.0	0.3	1.2
Miserableness	0.7	1.1	2.7	0.4	0.5	1.6	1.2
Medication: Atorvastatin	0.7	0.8	1.3	0.8	0.6	1.0	1.1
Fractured/broken bones in last 5 years	0.7	0.9	1.5	0.4	1.2	1.0	1.1
Myopia	0.7	1.1	1.7	0.7	1.3	-0.7	1.3
Heart disease (siblings)	0.7	0.9	2.5	1.6	0.5	0.4	0.7
Neuroticism (Nagel 2018)	0.6	1.4	3.2	0.8	0.3	1.2	1.8
Schizophrenia (2018)	0.6	1.2	2.8	-1.7	0.5	1.1	0.8
BMI	0.6	3.3	5.6	1.9	2.0	0.1	2.4
Cardiovascular Disease	0.6	1.9	2.6	1.4	1.4	-1.0	1.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.3	0.5	1.2	-0.9	0.6
Supplements: Glucosamine	0.6	0.8	2.5	0.8	-0.3	1.6	0.0
Forced vital capacity (FVC)	0.6	2.4	4.8	-2.2	-1.1	-0.5	-1.9
Arm fat percentage (right)	0.6	2.5	4.8	1.5	1.8	0.1	2.2
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	3.5	-1.9	-1.1	-0.5	-1.7
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.3	-0.3	1.0	0.6	1.1
Arm fat mass (right)	0.6	2.4	4.2	1.3	1.8	0.6	2.1
Body fat percentage	0.6	2.2	3.9	1.6	1.6	-0.2	2.0
Exposure to tobacco smoke outside home	0.6	0.8	2.9	0.6	0.0	1.7	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	0.4	-0.7	-0.8	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.0	0.7	1.4	-0.3	0.5
Whole body fat mass	0.6	2.7	3.9	1.9	1.8	0.1	2.0
Age at last live birth	0.6	0.9	1.6	-0.5	-1.3	-0.7	-1.1
Smoking status: Previous	0.6	0.9	1.5	-0.6	-0.9	1.2	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	0.9	0.7	0.4	0.9	0.9
Number of operations (self-reported)	0.6	0.9	1.2	1.1	0.5	1.0	1.0
Breast Cancer	0.5	1.3	2.8	-1.7	-1.2	-0.5	-0.9
Prostate Cancer	0.5	0.6	1.5	-0.1	0.6	1.2	0.9
Lupus	0.5	0.7	1.2	1.1	0.6	-0.9	0.6
Triglycerides	0.5	0.8	1.6	0.7	0.6	-1.3	0.9
Neuroticism	0.5	1.1	3.5	0.5	0.4	0.8	1.9
Supplements: Zinc	0.5	0.5	1.2	-0.0	1.1	-0.1	0.9
Severe depression (siblings)	0.5	0.6	1.7	0.4	0.7	-0.1	1.3
Age when periods started (menarche)	0.5	1.2	2.1	1.5	1.2	-0.9	0.8
Qualifications: CSEs or equivalent	0.5	0.7	1.6	-1.0	0.1	-1.3	-0.2
Multivitamins +/- minerals	0.5	0.6	2.2	0.2	0.3	-1.5	0.4
High blood pressure (mother)	0.5	0.8	1.8	-0.2	0.8	-1.3	0.7
Body mass index (BMI)	0.5	2.1	3.2	1.8	1.4	0.4	1.8
Financial difficulties in last 2 years	0.5	0.7	1.5	-1.2	-0.8	0.8	-0.3
Mouth/teeth dental problems	0.5	0.8	1.4	1.1	-1.2	0.3	-0.7
Fluid intelligence score	0.5	1.0	2.5	-0.5	-0.6	-1.6	-0.9
Hair/balding pattern: Pattern 3	0.5	0.8	2.6	1.6	0.8	-0.1	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.2	-0.3	0.9	0.4	1.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.3	-1.5	-0.0	-0.6	-0.6
Comparative body size at age 10	0.5	1.5	4.2	0.9	0.8	-2.0	0.3
Angina (self-reported)	0.5	0.6	2.0	-0.3	0.3	1.4	0.6
Medication: Ibuprofen	0.5	0.6	1.3	-0.0	1.1	0.3	1.1
Comparative height size at age 10	0.5	2.9	4.8	-2.2	-1.0	1.4	-1.9
Arm fat percentage (left)	0.5	2.1	4.1	1.4	1.6	-0.1	2.0
Average weekly red wine intake	0.5	0.7	0.8	0.9	0.9	0.9	0.7
Medication: Gliclazide	0.5	0.6	1.6	0.0	0.5	1.3	0.7
Arm fat mass (left)	0.5	2.0	3.3	1.4	1.6	0.3	1.8
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.7	1.3	0.8	0.5	0.1
Medication: Bendroflumethiazide	0.5	0.7	1.1	-0.6	-0.8	-0.8	-1.0
Irritability	0.5	0.9	2.3	0.7	0.4	0.8	1.5
Ever depressed for a whole week	0.5	0.6	1.9	1.4	0.2	-0.0	0.6
Depressed Affect (Nagel 2018)	0.4	0.9	2.1	0.1	-0.0	1.4	1.2
Alzheimer’s Disease (including proxy)	0.4	0.6	2.2	1.5	0.3	0.5	-0.1
Ovarian Cancer	0.4	0.5	0.9	0.8	-0.3	-0.7	-0.9
HbA1C	0.4	0.5	0.9	-0.7	-0.9	-0.2	-0.8
Hand grip strength (left)	0.4	1.2	1.6	-1.0	-1.1	0.9	-1.2
Hearing difficulty/problems: Yes	0.4	0.6	1.8	-0.2	-0.4	1.4	-0.5
Angina	0.4	0.5	1.1	0.1	0.5	1.1	0.7
Pack years adult smoking proportion	0.4	0.6	1.3	-1.1	-0.1	1.0	0.1
Trunk fat percentage	0.4	1.7	3.0	1.4	1.4	-0.3	1.7
Trunk fat mass	0.4	1.9	2.9	1.6	1.5	0.1	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.9	0.8	1.4	-0.6	1.0
Weight	0.4	1.8	2.3	1.5	1.4	1.0	1.4
Tense / ‘highly strung’	0.4	0.6	1.7	1.3	-0.2	0.4	0.7
Ever highly irritable/argumentative for 2 days	0.4	0.4	0.7	-0.8	0.6	0.2	0.8
Migraine (self-reported)	0.4	0.5	0.9	-0.9	-0.4	-0.3	-0.9
Suffer from ‘nerves’	0.4	0.6	1.4	0.8	0.4	-1.2	0.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.3	0.6	0.3	-1.2	0.0
Supplements: Vitamin C	0.4	0.4	1.1	-0.6	0.1	-1.0	0.5
Illnesses of siblings: Diabetes	0.4	0.5	1.1	-0.8	-0.2	-1.0	0.3
Asthma (self-reported)	0.4	0.8	1.7	0.2	1.1	-1.3	0.4
Guilty feelings	0.4	0.6	1.9	1.4	-0.2	0.8	0.1
Financial situation satisfaction	0.4	0.6	1.3	0.3	0.4	1.1	0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.2	0.8	-0.1	1.1	0.3
Crohns Disease (2017)	0.3	0.6	1.4	-0.2	-0.8	1.2	0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.4	1.0	0.2	-1.2	-0.3
Age at First Birth	0.3	0.5	0.9	-0.2	-1.0	0.5	-0.8
Crohns Disease (2012)	0.3	0.5	0.9	-0.8	-0.7	1.0	0.2
Blood Eosinophil Count	0.3	2.2	6.6	2.6	0.6	1.3	0.4
Blood Red Count	0.3	2.5	4.5	2.1	1.9	-0.3	1.4
Lung FVC	0.3	1.5	2.9	-1.6	-0.9	0.1	-1.7
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.4	0.0	0.1	1.2	0.5
Ever had hysterectomy (womb removed)	0.3	0.3	0.7	0.1	0.8	-0.7	0.0
Systolic blood pressure, automated reading	0.3	0.9	1.9	1.3	-0.2	1.4	0.1
Diabetes (mother)	0.3	0.4	1.5	-0.2	0.4	-1.2	-0.1
Relative age voice broke	0.3	0.5	1.8	1.3	0.3	0.4	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.4	0.2	1.2	0.2	1.0
Neuroticism score	0.3	0.5	1.6	0.6	0.5	-0.2	1.2
Alcohol intake versus 10 years previously	0.3	0.4	0.9	-0.9	-0.1	0.5	0.6
Mouth/teeth dental problems: Dentures	0.3	0.6	1.0	-0.1	0.7	0.9	1.0
Asthma	0.3	0.6	1.3	0.3	1.0	-1.1	0.4
Medication: Seretide 50 evohaler	0.3	0.3	0.7	0.8	0.8	0.1	-0.1
Family relationship satisfaction	0.3	0.4	0.5	0.7	0.6	0.6	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.2	0.5	-0.4	1.1	-0.1
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.6	-0.8	-0.7	0.6	-0.0
Loneliness, isolation	0.3	0.4	0.6	-0.7	-0.8	0.4	-0.5
Ever had bowel cancer screening	0.3	0.4	1.0	1.0	0.5	-0.5	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.9	-0.6	-0.2	-0.9	0.2
Back pain experienced in last month	0.3	0.4	1.2	-1.1	-0.5	-0.0	-0.2
Average weekly champagne plus white wine intake	0.3	0.4	0.9	0.6	0.6	-0.2	0.9
Wears glasses or contact lenses	0.3	0.3	0.6	0.8	0.5	-0.2	0.6
Hearing aid user	0.3	0.4	0.9	0.9	-0.2	0.8	-0.1
Illnesses of father: High blood pressure	0.3	0.3	0.7	-0.4	-0.2	-0.9	-0.6
Alcohol drinker status: Never	0.3	0.3	0.4	-0.7	-0.7	0.5	-0.4
Ever smoked	0.3	0.6	1.8	-0.3	-0.6	1.4	-0.4
Age started oral contraceptive pill	0.3	0.4	0.9	0.2	0.9	-0.8	0.2
Unable to work because of sickness or disability	0.3	0.4	1.2	-0.4	-0.3	1.1	0.1
Commuting to job workplace: Cycle	0.3	0.4	0.6	-0.8	-0.7	0.0	-0.6
Pain experienced in last month	0.3	0.6	1.5	-1.2	-0.6	-0.3	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.6	1.2	-0.1	1.1	0.0	1.1
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.6	1.3	0.5	-0.2	0.2
Irritable Bowel Disease (IBD)	0.2	0.4	0.8	0.2	-0.1	0.9	0.9
Mean Putamen Volume	0.2	0.2	0.6	0.8	-0.3	-0.0	-0.3
HDL Cholesterol	0.2	0.4	1.1	-1.0	-0.2	0.3	-0.6
Neuroticism (2016)	0.2	0.3	1.0	-0.1	-0.2	1.0	0.3
Schizophrenia (2014)	0.2	0.5	0.8	-0.7	0.9	0.2	0.8
Systolic Blood Pressure	0.2	0.8	2.3	0.6	0.0	1.5	0.6
Medication: Co-codamol	0.2	0.2	0.6	0.4	-0.4	0.8	0.3
Leg fat-free mass (left)	0.2	1.0	1.0	1.0	1.0	1.0	0.9
Hand grip strength (right)	0.2	0.6	1.1	-0.5	-0.7	1.1	-0.7
Current tobacco smoking	0.2	0.3	0.7	0.2	0.1	0.7	0.8
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	-0.9	-0.3	-0.5	0.5
Leg predicted mass (left)	0.2	0.9	1.1	1.0	0.9	1.1	0.8
Nervous feelings	0.2	0.4	0.8	0.5	0.2	-0.9	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	1.0	0.4	0.3	0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.4	-0.6	-0.5	0.6	-0.1
Allergy	0.2	0.4	0.8	0.9	-0.2	0.5	-0.7
Worrier / anxious feelings	0.2	0.5	1.3	-1.1	-0.6	0.1	-0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.1	-0.3	0.8	-1.1	-0.2
Depression (self-reported)	0.2	0.2	0.6	0.8	-0.2	0.4	-0.3
Length of working week for main job	0.2	0.3	0.6	0.1	-0.8	-0.4	-0.5
Birth weight of first child	0.2	0.4	0.8	0.6	0.9	-0.6	-0.1
Loud music exposure frequency	0.2	0.2	0.6	-0.3	-0.8	-0.5	-0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.4	-0.1	0.6	0.6	0.5
Medication: Allopurinol	0.2	0.2	0.6	0.1	0.5	-0.2	0.8
Chest pain or discomfort	0.2	0.3	0.7	0.4	-0.8	0.7	0.2
Had major operations	0.2	0.2	0.6	-0.5	-0.7	-0.2	0.2
Knee pain experienced in last month	0.2	0.3	0.4	0.6	0.5	0.5	0.4
Leg fat-free mass (right)	0.2	0.8	1.3	0.9	0.7	1.1	0.8
Medication: Aspirin	0.2	0.2	0.9	0.1	0.2	-1.0	0.0
Smoking status: Current	0.2	0.3	0.7	-0.4	-0.3	0.8	0.5
Leg predicted mass (right)	0.2	0.9	1.3	0.9	0.8	1.1	0.9
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	-0.2	0.7	-0.3	0.6
Commuting to job workplace: Public transport	0.2	0.3	0.5	0.2	-0.3	-0.6	-0.7
Pack years of smoking	0.2	0.3	0.7	-0.9	-0.2	0.7	-0.1
Impedance of whole body	0.2	0.9	2.1	-1.5	0.0	-1.1	-0.3
Worry (Nagel 2018)	0.1	0.2	0.5	0.3	-0.3	-0.2	0.7
Ulcerative Colitis (UC)	0.1	0.2	0.4	0.6	0.3	0.3	0.6
Reaction Time	0.1	0.2	0.7	0.2	0.1	-0.8	0.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.5	-0.1	-0.2	0.1
Heel T-Score	0.1	0.4	1.5	0.4	0.0	-1.2	-0.1
Height	0.1	1.2	2.4	1.1	1.1	1.6	-0.3
Allergy or Eczema	0.1	0.1	0.4	-0.2	0.1	-0.4	0.6
Respiratory disease	0.1	0.2	0.6	-0.2	-0.4	-0.1	-0.8
Lung FEV1/FVC ratio	0.1	0.8	1.3	-0.1	0.9	-0.9	1.1
Average weekly spirits intake	0.1	0.2	0.3	-0.5	0.3	0.2	0.5
Vitamin and mineral supplements	0.1	0.2	0.4	-0.0	-0.2	0.6	-0.6
Impedance of leg (right)	0.1	0.5	1.5	-1.2	0.4	-0.7	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	-0.2	-0.2	0.5	0.1
High blood pressure	0.1	0.2	0.3	0.6	0.3	-0.1	0.5
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.6	-0.1	0.0	-0.0
Sitting height	0.1	0.7	2.2	0.4	0.7	1.5	-0.4
Impedance of leg (left)	0.1	0.7	2.3	-1.5	0.2	-0.6	-0.1
Qualifications: None of the above	0.1	0.2	0.6	-0.3	-0.8	0.4	-0.4
Trunk fat-free mass	0.1	0.4	1.5	0.4	0.2	1.2	-0.3
Hip circumference	0.1	0.6	1.5	1.2	0.8	-0.1	0.6
Falls in the last year	0.1	0.1	0.3	-0.2	-0.2	-0.4	-0.5
Impedance of arm (left)	0.1	0.7	1.5	-1.2	-0.3	-0.9	-0.5
Trunk predicted mass	0.1	0.5	1.9	0.4	0.2	1.4	-0.2
Standing height	0.1	0.6	1.7	-0.6	0.2	1.3	-0.6
Arm fat-free mass (right)	0.1	0.4	1.2	0.5	0.2	1.1	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	0.6	0.3	0.2	0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.5	0.3	0.1	0.7	0.3
Mean time to correctly identify matches	0.1	0.2	0.6	0.8	-0.1	-0.2	0.1
Arm predicted mass (right)	0.1	0.4	0.9	0.6	0.4	1.0	0.1
Pulse rate, automated reading	0.1	0.4	0.5	-0.4	-0.6	-0.7	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	1.0	0.4	0.0	1.0	-0.1
Whole body fat-free mass	0.1	0.6	1.8	0.5	0.4	1.3	0.1
Qualifications: nursing, teaching	0.1	0.2	0.4	0.6	0.4	0.2	-0.4
Eye problems/disorders: Cataract	0.1	0.1	0.3	0.1	0.3	0.5	0.1
Whole body water mass	0.1	0.6	1.9	0.6	0.3	1.4	0.1
Basal metabolic rate	0.1	0.8	1.5	0.8	0.8	1.2	0.6
Arm fat-free mass (left)	0.1	0.6	1.6	0.6	0.6	1.3	0.3
Risk taking	0.1	0.2	0.3	0.3	-0.5	-0.4	-0.5
Diastolic blood pressure, automated reading	0.1	0.3	1.0	0.3	-0.1	1.0	0.3
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	-0.5	-0.6	-0.0	-0.9
Alcohol drinker status: Previous	0.1	0.1	0.1	-0.4	-0.3	-0.1	-0.2
Arm predicted mass (left)	0.1	0.6	1.7	0.8	0.5	1.3	0.1
Depression (Nagel 2018)	0.0	0.1	0.2	0.4	0.0	-0.1	0.2
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	-0.1	0.2	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.1	0.3	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.0	0.4	1.0	-0.0	-0.8	1.0	-0.2
Blood White Count	0.0	0.2	0.4	-0.1	-0.6	-0.5	-0.3
Hair Pigment	0.0	0.3	0.9	-0.2	-1.0	-0.1	-0.4
Tanning	0.0	0.2	0.5	-0.1	0.5	-0.7	0.1
Maternal smoking around birth	0.0	0.0	0.1	-0.0	-0.1	0.3	0.3
Impedance of arm (right)	0.0	0.2	0.6	-0.8	0.1	-0.1	0.1
Hair/balding pattern: Pattern 4	0.0	0.1	0.3	0.1	-0.1	-0.5	0.0
Peak expiratory flow (PEF)	0.0	0.1	0.2	-0.4	0.3	0.2	-0.0
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	0.0	-0.2	-0.0	-0.3
Heart disease (mother)	0.0	0.1	0.1	-0.2	-0.3	-0.2	-0.2
Medication: Aspirin	0.0	0.0	0.2	-0.1	-0.1	-0.4	-0.0
Hypertension (Self-reported)	0.0	0.1	0.3	0.4	0.3	-0.2	0.5
Illnesses of father: Heart disease	0.0	0.1	0.2	0.0	-0.3	-0.4	-0.2

Hub : Genes

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Trait associations