TWAS hub - FEM1A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Frontal Cortex BA9	0.5495	0.1169	3.4e-04	0.249	NA	0.132	NA	0.019	2.8e-07	NA	2.3e-04	NA	9.9e-02
2	GTEx	Cells Transformed fibroblasts	0.1390	0.0540	9.3e-03	0.051	NA	0.053	NA	0.044	1.1e-04	NA	7.2e-05	NA	3.1e-04
3	ROSMAP	Brain Pre-frontal Cortex	0.3396	0.0413	0.0e+00	0.199	0.213	0.245	0.229	0.251	4.5e-25	7.3e-27	3.1e-31	5.6e-29	5.1e-32
4	YFS	Blood	0.0582	0.0149	3.5e-07	0.028	0.025	0.032	0.033	0.033	9.7e-10	1.0e-08	1.1e-10	6.1e-11	3.9e-11
5	TCGA	Glioblastoma Multiforme	0.1520	0.0690	1.6e-03	0.017	0.067	0.031	NA	0.029	9.9e-02	4.4e-03	4.1e-02	NA	4.6e-02
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0585	0.0269	1.6e-03	-0.001	0.032	0.020	NA	0.008	3.8e-01	1.4e-04	2.1e-03	NA	3.8e-02
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0451	0.0212	7.4e-04	0.019	0.034	0.029	NA	0.023	2.6e-03	9.4e-05	2.7e-04	NA	1.1e-03
8	TCGA	Brain Lower Grade Glioma	0.0760	0.0347	1.4e-04	0.041	0.045	0.056	NA	0.056	1.8e-05	6.2e-06	5.6e-07	NA	6.2e-07
9	TCGA	Lung Adenocarcinoma	0.0305	0.0164	7.0e-03	0.037	0.016	0.018	NA	0.033	3.6e-05	4.5e-03	2.9e-03	NA	9.5e-05
10	TCGA	Pancreatic Adenocarcinoma	0.0960	0.0500	2.7e-03	0.104	0.050	0.031	NA	0.075	3.9e-05	3.8e-03	1.9e-02	NA	4.6e-04
11	TCGA	Pheochromocytoma and Paraganglioma	0.1030	0.0560	6.8e-03	0.073	0.038	0.048	NA	0.056	7.5e-04	1.2e-02	5.5e-03	NA	3.0e-03
12	TCGA	Prostate Adenocarcinoma	0.0300	0.0150	3.1e-03	0.011	0.012	0.018	NA	0.018	2.2e-02	1.9e-02	5.0e-03	NA	5.2e-03
13	TCGA	Thyroid Carcinoma	0.0480	0.0230	1.4e-03	0.026	0.012	0.031	NA	0.025	1.3e-03	2.2e-02	4.8e-04	NA	1.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Mouth/teeth dental problems: Mouth ulcers	11.0	17.4	37.4	-4.2	-4.7	-4.4	-3.6	-2.1	-4.0	-3.9	-1.5	-3.6	-6.1	-5.4	-4.7	-3.8
Hypothyroidism (self reported)	8.2	18.7	45.2	-4.3	-3.1	-3.3	-2.9	-4.5	-6.3	-3.6	-2.7	-1.7	-6.7	-4.5	-6.4	-2.7
Medication: Levothyroxine sodium	6.7	11.3	29.9	-3.1	-2.4	-2.4	-2.0	-3.5	-4.9	-2.9	-2.5	-1.1	-5.5	-3.3	-5.1	-2.0
Average weekly red wine intake	5.7	8.4	14.0	-3.0	-3.6	-3.4	-3.7	-1.4	-0.9	-2.7	-2.6	-3.6	-2.6	-2.7	-2.1	-3.7
Hypothyroidism/myxoedema (self-reported)	5.4	10.5	31.5	-2.9	-2.1	-2.3	-2.0	-3.6	-4.1	-2.7	-2.3	-0.9	-5.6	-3.3	-5.1	-1.9
Number of incorrect matches in round	4.5	7.4	12.1	2.6	2.8	2.7	2.8	2.9	1.4	2.7	3.2	1.9	2.9	2.7	3.5	2.6
Alcohol usually taken with meals	4.1	6.7	9.9	-2.3	-2.7	-2.8	-3.1	-1.7	-1.8	-2.7	-3.1	-2.7	-2.6	-2.4	-2.3	-2.9
Commuting to job workplace: Walk	4.0	4.3	6.5	-2.5	-2.5	-2.4	-2.3	-0.3	-1.8	-1.5	-1.7	-2.0	-2.0	-2.4	-1.9	-2.3
Illnesses of siblings	3.4	4.8	7.6	-2.8	-2.2	-2.5	-2.3	-1.2	-2.0	-2.6	-1.8	-2.1	-1.8	-2.5	-2.0	-2.2
Medication: Amlodipine	3.4	4.7	10.2	2.6	1.9	2.2	2.1	1.8	1.2	1.7	1.5	2.0	3.2	2.2	2.8	2.2
Ever had stillbirth, spontaneous miscarriage or termination	3.4	3.6	6.5	-2.4	-2.5	-2.4	-2.5	-0.9	-0.4	-1.6	-0.7	-2.2	-1.5	-1.9	-1.6	-2.3
Pack years of smoking	3.3	4.8	7.1	2.4	2.5	2.3	2.0	1.3	1.9	2.7	1.0	2.3	2.6	2.7	2.1	2.2
Rheumatoid Arthritis	3.2	4.4	7.6	-2.5	-2.4	-1.7	-1.4	-2.1	-2.2	-2.2	-0.7	-2.0	-2.8	-2.0	-2.5	-1.9
Worry (Nagel 2018)	3.1	6.6	9.1	-2.4	-2.5	-2.9	-2.8	-2.6	-1.1	-2.8	-0.9	-3.0	-2.6	-2.9	-3.0	-2.9
Basal cell carcinoma (self-reported)	3.1	3.7	7.2	1.9	2.3	2.1	1.7	1.1	1.7	1.2	1.6	1.1	2.7	2.6	2.4	1.8
High blood pressure (siblings)	2.8	4.1	7.0	2.6	2.1	2.1	1.7	1.7	1.4	2.1	1.3	1.6	2.2	2.5	2.5	1.8
Qualifications: O levels/GCSEs or equivalent	2.7	4.3	8.0	-2.3	-2.3	-2.3	-2.0	0.1	-1.6	-1.7	-0.8	-2.5	-2.8	-2.7	-1.8	-2.2
Diabetes (mother)	2.6	3.3	5.1	2.2	2.2	2.2	1.7	0.6	1.6	2.1	0.4	2.0	1.5	2.3	1.7	1.9
Number of full brothers	2.6	3.3	5.2	2.1	2.3	1.9	1.8	1.6	1.1	2.2	1.3	1.9	1.5	1.8	1.8	2.1
Reason for reducing amount of alcohol drunk: Health precaution	2.5	3.0	5.2	1.6	1.3	1.9	2.1	1.8	0.6	1.8	2.3	1.6	1.1	1.6	1.9	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	3.0	5.2	-1.8	-2.1	-1.7	-1.9	-0.9	-1.2	-2.1	-1.7	-1.8	-2.3	-1.6	-1.2	-1.9
Noisy workplace	2.3	2.8	6.1	1.4	2.1	1.8	1.6	0.5	0.6	2.2	1.6	2.5	1.8	1.6	0.7	2.0
Medication: Aspirin	2.3	3.0	5.3	1.7	2.3	1.9	1.7	-0.0	1.8	1.9	1.1	2.1	1.7	1.8	1.3	1.9
Pack years adult smoking proportion	2.2	3.4	5.4	1.9	2.0	1.9	1.6	1.1	1.5	2.3	0.8	1.9	2.2	2.3	1.8	1.8
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.6	5.8	1.9	1.8	1.7	1.5	-0.3	1.9	2.1	-0.5	2.4	0.9	1.7	0.8	1.8
Eye problems/disorders: Glaucoma	2.2	2.6	9.1	1.1	1.3	1.1	1.0	2.3	1.2	1.7	1.4	0.7	3.0	1.1	2.3	1.0
Ever had prostate specific antigen (PSA) test	2.2	2.5	4.6	-1.8	-1.7	-1.4	-1.5	-2.1	-1.2	-2.2	0.5	-1.9	-1.3	-0.8	-1.6	-1.6
Alcohol intake versus 10 years previously	2.1	3.1	8.6	1.5	2.2	1.6	2.1	1.1	-1.1	2.3	2.9	2.1	0.9	0.6	0.5	2.1
Pulse wave reflection index	2.1	2.6	4.0	-2.0	-1.3	-1.8	-1.9	-1.1	-1.5	-1.1	-1.9	-0.9	-1.8	-1.9	-1.9	-1.4
Qualifications: College or University degree	2.1	6.6	12.7	-2.9	-2.7	-2.8	-2.6	-1.9	-1.3	-3.5	-1.2	-3.6	-2.2	-2.5	-2.1	-3.0
Hayfever, allergic rhinitis or eczema	1.9	4.0	6.5	-2.5	-2.2	-2.2	-1.8	-2.1	-0.6	-2.4	-0.7	-2.1	-1.9	-2.1	-2.3	-2.2
Trunk fat mass	1.9	8.1	16.0	3.4	4.0	3.4	2.9	0.1	2.7	3.2	0.7	3.8	1.5	3.1	1.5	3.4
Exposure to tobacco smoke outside home	1.9	2.6	6.2	2.4	1.6	1.4	0.9	1.2	1.4	1.4	0.5	1.1	2.5	1.9	2.2	1.2
Medication: Allopurinol	1.9	2.6	7.6	-1.2	-1.2	-1.4	-1.3	-2.8	-0.6	-2.1	-1.2	-1.2	-1.7	-1.3	-2.1	-1.5
Trunk fat percentage	1.8	7.0	15.4	3.3	3.9	3.1	2.7	-0.1	1.9	2.9	0.8	3.6	1.6	2.7	1.2	3.2
Whole body fat mass	1.8	7.4	14.7	3.3	3.8	3.3	2.7	-0.3	2.8	3.0	0.5	3.6	1.4	3.1	1.3	3.1
Waist circumference	1.7	6.4	13.0	2.8	3.6	3.0	2.3	-0.4	2.8	2.8	0.2	3.4	1.4	3.0	1.2	2.9
Body fat percentage	1.7	6.8	14.9	3.3	3.9	3.1	2.6	-0.4	2.0	2.7	0.5	3.5	1.6	2.9	1.2	3.0
Medication: Aspirin	1.7	2.2	4.4	1.5	2.1	1.6	1.4	-0.0	1.6	1.6	1.0	1.7	1.7	1.6	1.2	1.6
Allergy or Eczema	1.6	4.2	6.3	-2.5	-2.5	-2.2	-2.1	-2.1	-0.1	-2.4	-1.2	-2.0	-1.6	-1.9	-2.2	-2.3
Weight	1.6	8.0	13.2	3.2	3.6	3.4	2.8	0.3	3.6	3.0	0.8	3.4	1.4	3.4	1.8	3.2
Back pain experienced in last month	1.6	2.3	4.5	1.2	2.0	1.4	1.3	2.1	-0.1	1.9	1.7	1.5	1.1	0.9	1.5	1.7
Leg fat percentage (left)	1.6	5.7	12.1	3.1	3.5	2.9	2.1	-1.1	2.2	2.1	-0.5	3.0	1.5	3.1	1.1	2.5
Arm fat percentage (right)	1.5	5.9	13.0	3.2	3.6	3.0	2.5	-0.5	1.4	2.6	0.6	3.3	1.0	2.7	1.1	2.9
Qualifications: A levels/AS levels or equivalent	1.5	3.3	9.4	-1.6	-2.1	-1.8	-1.5	-0.5	-1.2	-1.7	-1.0	-2.0	-3.1	-2.3	-1.7	-1.8
Arm fat mass (right)	1.5	6.3	12.4	3.1	3.5	3.1	2.6	-0.2	2.2	2.9	0.6	3.4	0.9	2.8	1.2	3.0
Leg fat percentage (right)	1.5	5.5	11.8	3.1	3.4	2.9	2.1	-1.2	2.1	2.1	-0.5	3.0	1.4	3.0	0.9	2.5
Chest pain or discomfort	1.5	2.2	3.7	1.2	1.6	1.4	1.6	1.8	0.3	1.9	1.8	1.7	1.0	0.8	1.2	1.8
Arm fat percentage (left)	1.5	6.0	14.3	3.1	3.8	3.0	2.5	-0.6	1.7	2.6	0.3	3.3	1.1	2.7	1.1	2.9
Medication: Bendroflumethiazide	1.5	2.3	5.0	1.7	1.5	1.6	1.9	0.6	2.2	1.6	0.7	1.9	1.0	1.2	1.0	1.6
Maternal smoking around birth	1.4	2.1	4.7	-1.6	-1.7	-1.5	-1.9	-1.2	0.4	-1.8	-1.2	-2.2	-0.4	-0.7	-0.5	-2.0
Taking other prescription medications	1.4	2.2	7.8	-1.3	-0.7	-1.1	-1.7	-2.8	-0.9	-1.3	-1.2	-0.9	-1.8	-0.4	-2.1	-1.4
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.0	1.0	1.6	0.8	1.1	1.4	1.4	1.4	1.7	1.0	1.4	0.6	1.2	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	3.9	2.0	1.4	1.2	1.0	0.7	0.7	1.1	0.4	1.1	1.8	1.5	1.5	1.2
Arm fat mass (left)	1.4	5.6	11.0	2.9	3.3	2.9	2.4	-0.3	2.3	2.6	0.4	3.1	0.9	2.7	1.1	2.8
Average weekly beer plus cider intake	1.4	2.0	4.6	0.7	0.9	1.1	1.7	1.9	0.5	1.5	2.2	1.4	1.7	0.6	1.5	1.5
Smoking Status	1.3	3.2	8.4	1.0	1.7	1.5	1.8	2.7	0.4	2.1	2.9	1.3	1.6	1.2	1.9	1.8
Neuroticism	1.3	3.1	5.5	-1.1	-1.3	-1.9	-2.3	-2.2	-0.3	-1.9	-0.5	-2.3	-1.9	-1.3	-2.0	-2.2
Qualifications: CSEs or equivalent	1.3	1.7	7.0	-1.2	-1.5	-1.0	-0.6	-1.3	-0.4	-1.1	-0.2	-0.9	-2.6	-1.3	-1.8	-1.0
Multivitamins +/- minerals	1.3	1.6	4.1	-1.2	-1.0	-1.2	-1.4	-1.3	0.2	-1.6	-2.0	-1.6	-0.4	-0.5	-0.9	-1.6
Body mass index (BMI)	1.3	5.7	11.1	2.9	3.3	2.8	2.3	-0.4	2.7	2.6	0.6	2.9	1.4	2.8	1.3	2.6
Hair/balding pattern: Pattern 2	1.3	1.6	4.5	-1.1	-1.4	-1.1	-1.6	-0.9	-0.9	-2.1	-1.7	-1.5	-0.9	-0.3	-0.4	-1.3
Mouth/teeth dental problems	1.3	2.0	5.6	1.3	1.5	1.4	1.2	0.7	1.0	1.0	1.0	1.1	2.4	1.8	1.7	1.4
Allergy	1.3	3.0	4.3	2.1	1.9	1.8	1.7	1.8	0.6	1.9	0.4	1.9	1.9	1.7	1.8	2.0
Angina (self-reported)	1.3	1.7	4.1	1.2	1.5	1.3	1.3	0.6	0.3	1.6	1.1	2.0	1.3	0.8	0.9	1.7
Leg fat mass (right)	1.3	5.1	10.6	2.7	3.3	2.8	2.0	-1.4	2.6	2.1	-0.3	2.9	0.8	2.9	0.6	2.4
Knee pain experienced in last month	1.3	2.0	4.0	1.6	1.3	1.4	1.0	0.4	2.0	1.7	-0.0	1.6	1.4	1.9	1.4	1.3
Leg fat mass (left)	1.3	5.1	10.6	2.7	3.2	2.7	2.0	-1.2	2.6	2.1	-0.3	2.9	0.7	2.9	0.6	2.4
Neuroticism (Nagel 2018)	1.2	2.9	5.5	-0.9	-1.2	-2.0	-2.3	-1.9	-0.1	-1.6	-1.0	-2.1	-1.9	-1.5	-2.1	-2.1
Mean Putamen Volume	1.2	1.4	3.7	-1.3	-1.4	-1.2	-1.0	-0.4	-1.9	-1.3	-0.4	-1.2	-0.8	-1.4	-1.1	-1.2
Blood Eosinophil Count	1.2	9.6	18.1	3.7	3.7	3.4	2.6	1.8	2.5	3.2	0.7	2.8	3.2	4.2	3.8	3.0
Past tobacco smoking	1.2	2.1	9.8	-0.1	-0.7	-0.5	-0.6	-3.1	0.6	-2.0	-2.2	-0.5	-1.9	-0.2	-1.7	-0.9
Hip circumference	1.2	5.2	11.2	2.5	2.8	2.6	2.2	0.5	3.4	2.7	0.6	2.7	1.2	2.4	1.4	2.5
Worrier / anxious feelings	1.2	2.3	4.6	-1.3	-1.7	-1.9	-1.7	-0.8	-1.3	-1.7	-0.5	-1.7	-0.6	-2.1	-1.5	-1.7
Tense / ‘highly strung’	1.2	1.9	4.4	-0.9	-1.1	-1.6	-1.9	-1.4	-0.6	-1.8	-0.3	-2.1	-1.3	-1.1	-1.0	-1.8
Medication: Ventolin 100micrograms inhaler	1.2	1.6	3.4	-1.9	-1.7	-1.5	-1.2	-0.1	-0.5	-1.1	-0.1	-1.2	-1.2	-1.8	-1.0	-1.3
Medication: Blood pressure	1.2	2.0	3.8	1.6	1.9	1.2	1.4	0.9	0.9	1.9	1.3	1.2	1.8	1.2	1.3	1.3
Schizophrenia (2018)	1.1	2.3	8.4	-1.7	-1.5	-1.7	-1.3	-0.1	-2.9	-1.3	-0.5	-1.6	-0.6	-2.0	-1.3	-1.4
Crohns Disease (2012)	1.1	1.8	6.1	1.4	1.2	1.3	0.8	0.1	2.5	0.8	0.2	0.9	1.4	2.0	1.5	0.9
Hearing difficulty/problems: Yes	1.1	1.7	6.8	1.6	0.9	1.3	1.0	0.3	2.6	1.1	0.1	1.7	0.3	1.4	1.1	1.2
Angina	1.1	1.4	4.2	1.2	1.3	1.2	1.3	0.3	0.2	1.5	1.1	2.0	1.0	0.7	0.6	1.6
Age when periods started (menarche)	1.1	2.7	4.1	1.6	1.9	2.0	1.8	0.9	0.3	2.0	0.5	2.0	1.5	2.0	1.6	1.9
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	4.3	1.0	0.8	1.1	1.3	0.7	0.1	0.0	2.1	0.8	0.9	1.0	1.2	1.2
High blood pressure (mother)	1.1	1.5	3.3	1.8	1.8	1.4	1.2	-1.0	1.1	0.9	-0.0	1.7	0.7	1.2	0.1	1.3
Neuroticism score	1.1	2.3	3.6	-1.0	-1.3	-1.7	-1.9	-1.8	-0.8	-1.8	-0.5	-1.8	-1.4	-1.3	-1.7	-1.8
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	4.1	-1.4	-1.9	-1.3	-1.2	-0.3	-1.2	-1.5	-0.6	-1.2	-2.0	-1.5	-1.3	-1.2
Glaucoma (self-reported)	1.1	1.3	3.9	0.7	1.2	0.9	0.7	1.5	-0.1	1.3	1.3	0.5	2.0	0.8	1.5	0.9
Heart disease (mother)	1.1	1.4	5.2	0.8	1.2	0.9	0.7	2.3	-1.2	1.7	1.1	0.5	0.3	0.8	1.3	1.0
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.7	-1.6	-1.1	-1.4	-1.3	-0.8	-0.0	-0.6	-1.3	-1.0	-0.8	-1.2	-1.3	-1.4
Osteoporosis (self-reported)	1.1	1.3	2.1	-1.3	-1.3	-1.3	-1.3	-0.7	-1.4	-0.8	-0.6	-0.8	-1.0	-1.3	-1.4	-1.2
Osteoarthritis (self-reported)	1.1	1.4	3.4	1.1	1.3	1.3	1.2	0.6	-0.1	1.7	0.2	1.8	1.3	1.0	0.6	1.4
Medication: Gliclazide	1.1	1.3	2.4	1.5	1.4	1.0	0.6	0.4	1.4	1.4	-0.8	1.2	1.0	1.3	0.7	1.1
Medication: Lisinopril	1.1	1.4	3.6	1.3	0.9	1.5	1.7	0.1	-0.9	1.7	0.4	1.9	-0.5	1.0	-0.1	1.5
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.7	-1.1	-1.4	-1.3	-1.2	0.1	-1.6	-1.1	0.9	-1.3	-1.2	-1.4	-0.9	-1.2
Relative age of first facial hair	1.0	2.0	3.9	1.8	2.0	1.8	1.3	0.2	-0.2	1.7	0.3	1.8	0.6	1.9	0.9	1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	3.5	-1.6	-1.6	-1.9	-1.8	-0.8	-1.8	-0.8	-1.6	-1.3	-0.3	-1.8	-1.6	-1.7
Qualifications: None of the above	1.0	2.1	4.2	1.5	1.6	1.5	1.6	0.4	1.2	1.2	1.0	2.0	2.1	1.3	1.0	1.7
Financial difficulties in last 2 years	1.0	1.3	4.2	1.1	1.3	1.0	0.8	2.0	0.2	1.2	0.6	0.6	1.4	0.8	1.5	1.1
Birth weight of first child	1.0	1.8	4.9	1.4	1.6	1.4	1.6	1.0	0.7	2.1	0.2	2.2	0.4	0.5	0.4	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	2.2	-1.5	-0.8	-1.2	-1.2	-0.6	-1.4	-1.0	-0.0	-1.1	-1.2	-1.5	-1.1	-1.0
Friendships satisfaction	1.0	1.3	3.2	-0.5	-0.6	-1.0	-1.7	-1.5	0.3	-1.6	-1.0	-1.8	-0.5	0.2	-0.6	-1.6
Myopia	1.0	1.5	3.8	-1.0	-1.0	-0.9	-0.9	-1.1	-1.9	-1.1	-1.0	-1.0	-2.0	-1.0	-1.6	-0.9
Bipolar Disorder or Schizophrenia	0.9	2.3	8.2	-1.6	-1.3	-1.8	-1.7	-0.1	-2.9	-0.8	-1.2	-1.5	-0.0	-1.8	-1.2	-1.5
Reaction Time	0.9	1.7	5.1	-1.6	-1.2	-1.1	-0.5	-0.3	-2.3	-0.7	0.2	-0.6	-1.6	-2.2	-1.6	-0.7
Chronotype (morning person)	0.9	2.2	5.6	2.1	1.4	1.9	1.7	-1.1	1.0	1.1	-1.0	2.4	-1.0	1.4	-0.2	1.6
Medication: Ramipril	0.9	1.2	5.2	-0.8	-0.5	-1.1	-1.6	-1.2	0.6	-0.2	-2.3	-0.9	-0.6	-0.2	-0.9	-1.2
Illnesses of mother	0.9	1.1	3.4	-1.0	-1.8	-1.2	-0.7	0.0	0.5	-1.5	-0.1	-0.9	-1.3	-1.4	-0.6	-0.9
Blood clot in the leg (DVT)	0.9	1.2	2.6	1.4	0.9	1.1	1.0	0.0	0.9	0.2	1.5	0.2	1.5	1.6	1.5	0.7
Leg pain on walking	0.9	1.1	2.6	1.4	1.3	1.3	1.0	-0.1	0.6	1.3	0.2	1.6	0.5	1.0	0.4	1.3
Commuting to job workplace: Car/motor vehicle	0.9	1.0	3.3	0.3	0.9	0.7	0.8	1.2	0.5	0.4	1.5	0.6	1.8	0.6	1.3	0.9
Unable to work because of sickness or disability	0.9	1.2	2.5	1.5	0.9	0.8	0.6	1.4	0.7	1.6	1.0	0.9	1.3	1.0	1.0	0.9
Arm predicted mass (left)	0.9	4.5	12.7	2.0	1.9	2.5	2.1	1.1	3.6	2.1	0.9	2.3	1.0	2.6	1.8	2.3
Depression (Nagel 2018)	0.8	1.1	2.9	-0.9	-0.8	-1.3	-1.2	-0.2	-0.3	-0.3	0.1	-1.1	-1.7	-1.7	-1.3	-1.1
Crohns Disease (2017)	0.8	1.8	6.0	1.6	1.2	1.1	0.3	-1.2	2.5	-0.5	-0.1	0.2	1.7	2.4	1.3	0.4
Primary Biliary Cirrhosis	0.8	1.2	5.2	-0.6	-0.7	-0.4	-0.4	-2.3	0.9	-0.7	-1.1	-0.1	-1.7	-0.5	-1.8	-0.6
Ever used hormone-replacement therapy (HRT)	0.8	1.0	3.1	-1.8	-1.2	-1.1	-1.1	-0.4	-0.0	-0.7	-0.0	-0.6	-1.3	-1.0	-1.2	-0.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.3	-0.8	-0.4	-0.9	-1.5	-1.4	0.4	-1.4	-1.3	-0.5	-0.3	-0.5	-1.0	-0.7
Severe depression (siblings)	0.8	0.8	2.0	-0.6	-0.8	-0.7	-0.9	-1.1	-0.7	-1.3	-0.0	-1.1	-1.4	-0.8	-1.0	-0.9
High blood pressure	0.8	2.3	4.5	1.8	1.8	1.5	1.4	0.1	2.0	1.6	-0.1	2.1	1.3	1.8	0.8	1.6
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	7.0	-0.9	0.0	0.0	0.7	1.4	-0.2	0.4	2.7	-0.1	0.3	-0.3	0.8	0.4
Nervous feelings	0.8	1.5	2.9	-0.8	-1.2	-1.3	-1.1	-1.6	-0.8	-1.1	-0.1	-1.1	-1.3	-1.7	-1.7	-1.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.8	-1.0	-1.0	-1.0	-1.3	-1.1	0.4	-1.3	-0.9	-0.9	-1.4	-0.8	-1.0	-1.0
Medication: Cholesterol lowering	0.8	1.2	3.8	1.3	1.5	1.1	0.9	-0.9	0.9	0.3	0.5	0.8	2.0	1.5	0.8	0.8
Gout (self-reported)	0.8	1.1	7.6	-0.2	-0.3	-0.3	-0.6	-2.8	0.2	-1.3	-1.4	-0.3	-0.6	0.1	-1.2	-0.7
Number of children fathered	0.8	0.9	4.1	0.5	0.4	0.3	0.1	2.0	1.0	1.3	-1.2	0.2	0.9	0.5	1.3	0.2
Neck or shoulder pain in last month	0.8	1.1	2.2	1.5	1.0	1.3	1.3	0.3	-0.0	1.5	0.8	1.4	-0.4	1.1	0.4	1.3
Smoking status: Previous	0.8	1.3	6.8	-0.1	0.1	0.1	0.2	2.6	-0.3	1.5	1.5	0.1	1.6	-0.2	1.4	0.4
High cholesterol (Self-reported)	0.8	1.4	3.7	1.7	1.9	1.3	0.7	-1.0	0.1	0.2	-0.9	1.3	1.3	1.8	0.6	1.1
Basal metabolic rate	0.8	4.5	11.7	2.0	2.3	2.5	2.1	0.6	3.4	2.4	0.9	2.4	0.7	2.6	1.5	2.3
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	2.3	1.4	0.8	1.1	1.0	0.1	0.8	0.2	1.4	0.2	1.4	1.5	1.4	0.6
Schizophrenia (2014)	0.7	1.6	5.5	-1.1	-1.1	-1.2	-1.1	-0.7	-2.4	-1.3	-0.9	-1.3	-0.7	-1.4	-1.2	-1.3
Ulcerative Colitis	0.7	1.0	2.7	-1.0	-0.8	-0.9	-0.8	-1.0	-1.1	-0.7	-1.1	-0.5	-1.2	-1.2	-1.6	-0.8
Type 2 Diabetes (T2D) (2018)	0.7	1.2	2.4	1.3	1.2	1.3	0.9	-0.1	1.3	1.3	-0.3	1.6	0.9	1.1	0.4	1.3
Supplements: Zinc	0.7	0.8	1.7	-1.0	-1.0	-0.8	-1.2	-0.4	-0.8	-0.8	-1.1	-1.3	0.4	-0.3	-0.0	-1.2
Medication: Metformin	0.7	1.0	2.9	1.1	1.6	0.9	0.5	-0.5	0.8	1.7	-0.7	1.7	0.5	0.6	-0.4	1.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.5	1.0	1.0	1.1	1.1	-0.0	0.3	0.9	-0.3	1.6	0.8	1.1	0.5	1.1
Number of live births	0.7	1.0	5.3	-0.3	-0.0	-0.1	0.1	2.3	-0.7	0.7	1.9	-0.2	1.0	-0.0	1.4	0.3
Exposure to tobacco smoke at home	0.7	0.8	2.0	0.7	0.8	0.7	0.7	1.3	-0.8	0.5	1.4	0.7	1.2	0.4	1.1	1.0
Arm fat-free mass (right)	0.7	3.5	13.8	1.5	1.7	2.1	1.8	0.7	3.7	1.7	0.7	1.9	0.8	2.3	1.5	1.9
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.4	1.0	0.3	1.1	1.0	0.0	0.2	-0.4	1.6	0.8	1.2	1.3	0.7	0.9
Whole body fat-free mass	0.7	3.7	11.2	1.6	1.9	2.2	1.9	0.9	3.3	2.2	0.9	2.0	0.6	2.3	1.5	2.0
Leg fat-free mass (right)	0.7	3.6	8.5	1.6	2.3	2.2	1.9	0.6	2.9	2.3	1.0	2.1	0.4	2.2	1.3	2.1
Medication: Paracetamol	0.7	1.1	2.2	1.5	1.4	1.3	0.9	0.1	-0.3	1.5	0.1	1.5	0.3	1.2	0.4	1.2
Ever smoked	0.7	1.2	6.3	-0.2	0.3	0.0	0.3	2.5	-1.5	1.3	1.6	0.2	1.0	-0.3	0.9	0.4
Arm fat-free mass (left)	0.7	3.5	11.4	1.7	1.7	2.2	1.8	0.8	3.4	1.9	0.6	1.9	0.8	2.4	1.6	1.9
HbA1C	0.6	0.7	1.9	-1.1	-0.6	-0.7	-0.4	-0.6	-1.1	-1.4	0.6	-1.3	0.7	-0.6	0.1	-0.7
Waist Hip Ratio (WHR)	0.6	2.8	7.7	1.8	2.8	1.7	0.8	-1.1	0.9	1.6	-1.0	2.1	1.7	2.4	0.6	1.5
Leg fat-free mass (left)	0.6	3.2	8.3	1.5	2.2	2.1	1.8	0.4	2.9	2.2	0.9	2.0	0.4	2.0	1.1	1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.1	-1.3	-1.3	-1.4	-1.5	-0.7	-1.3	-0.4	-1.3	-1.0	-0.2	-1.3	-1.2	-1.3
Supplements: Glucosamine	0.6	0.8	2.1	-0.8	-0.8	-0.8	-1.3	1.0	1.5	0.2	-0.8	-0.9	0.7	-0.3	0.5	-0.9
Leg predicted mass (left)	0.6	3.4	8.4	1.6	2.2	2.2	1.8	0.5	2.9	2.2	0.9	2.0	0.5	2.1	1.2	2.0
Pain all over the body in last month	0.6	0.7	3.4	-0.3	-0.1	-0.1	-0.4	-1.9	-0.5	-1.6	0.1	-0.3	-0.9	0.2	-1.1	-0.4
Trunk fat-free mass	0.6	3.6	10.9	1.6	1.6	2.2	1.9	1.2	3.3	2.1	0.8	1.9	0.5	2.3	1.6	2.0
Hair/balding pattern: Pattern 3	0.6	0.9	2.9	1.3	0.7	0.8	1.1	0.9	-0.4	1.4	0.4	1.7	0.7	0.2	0.1	1.2
Pulse wave Arterial Stiffness index	0.6	0.7	3.8	-0.5	0.4	-0.2	-0.7	-1.6	0.1	-0.3	-2.0	0.5	-0.2	0.1	-0.9	-0.1
Trunk predicted mass	0.6	3.4	10.7	1.6	1.6	2.1	1.9	1.1	3.3	2.1	0.8	1.9	0.4	2.2	1.6	1.9
Ever highly irritable/argumentative for 2 days	0.6	0.8	1.9	0.7	0.8	1.0	0.9	-0.1	0.7	1.2	1.2	1.4	0.4	1.0	0.3	1.0
Shortness of breath walking on level ground	0.6	0.7	2.2	0.9	1.5	1.0	0.7	-0.7	0.2	0.5	-0.4	1.2	-0.4	1.0	-0.5	0.9
Emphysema/chronic bronchitis	0.6	0.7	4.4	-0.1	-0.7	-0.5	-0.4	0.6	-1.0	0.8	-0.6	0.3	-2.1	-0.9	-1.0	-0.1
Mean time to correctly identify matches	0.6	1.1	3.8	-1.3	-1.2	-1.0	-0.5	0.0	-1.6	-0.6	0.2	-0.4	-1.2	-1.9	-1.2	-0.6
Arm predicted mass (right)	0.6	3.1	12.4	1.4	1.6	2.1	1.7	0.6	3.5	1.6	0.7	1.7	0.6	2.2	1.3	1.8
Supplements: Vitamin C	0.6	0.7	3.3	1.1	1.1	0.7	0.3	-0.6	1.8	0.4	-0.4	0.3	-0.3	1.2	0.4	0.3
Hypertension (Self-reported)	0.6	1.6	3.2	1.5	1.5	1.2	1.1	-0.2	1.8	1.2	-0.2	1.8	1.2	1.5	0.5	1.3
Medication for cholesterol	0.6	0.9	4.7	0.0	0.0	0.4	0.9	2.2	-0.3	0.9	1.6	-0.1	0.7	-0.3	1.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.7	-1.5	-1.6	-0.8	-0.1	-0.4	-0.5	-1.6	0.5	-1.2	-1.4	-1.4	-0.7	-0.8
Whole body water mass	0.6	3.4	10.9	1.5	1.7	2.1	1.8	1.0	3.3	2.1	0.9	1.8	0.5	2.2	1.5	1.9
Leg predicted mass (right)	0.6	3.4	8.2	1.6	2.2	2.2	1.8	0.5	2.9	2.3	1.0	2.1	0.3	2.1	1.2	2.1
Pain experienced in last month	0.6	1.0	2.4	-1.4	-0.9	-1.0	-1.0	-0.3	-1.2	-1.2	-0.7	-1.6	-0.1	-0.9	-0.4	-1.1
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.4	-1.5	-1.8	-1.4	-1.3	-0.3	-0.7	-1.8	-0.4	-1.6	-1.1	-1.0	-0.7	-1.5
Age at First Birth	0.5	0.7	4.2	0.4	0.2	0.7	0.6	0.2	2.0	0.0	0.7	0.4	0.7	1.2	1.0	0.6
Average weekly spirits intake	0.5	0.6	2.2	0.9	0.7	0.6	0.0	-0.2	0.8	0.4	-0.4	0.3	1.5	1.3	1.1	0.3
Fed-up feelings	0.5	0.9	2.8	-0.1	-0.1	-0.7	-1.1	-1.6	-0.4	-0.5	-1.1	-0.2	-1.4	-0.5	-1.7	-0.7
Falls in the last year	0.5	0.6	3.0	0.3	0.0	0.2	-0.2	0.4	1.7	0.7	0.3	-0.1	1.4	0.9	1.2	-0.1
Length of working week for main job	0.5	0.5	1.4	-0.9	-0.1	-0.7	-0.7	1.2	-0.7	0.5	-0.5	-0.6	1.0	-0.9	0.2	-0.5
Age at first live birth	0.5	0.8	4.7	0.5	0.9	0.4	0.4	0.9	2.2	1.0	0.2	0.3	1.4	0.6	0.8	0.4
Pulse wave peak to peak time	0.5	0.6	2.8	0.5	-0.4	0.2	0.6	1.7	0.0	0.3	1.6	-0.4	0.2	-0.1	1.0	0.2
Medication: Seretide 50 evohaler	0.5	0.5	1.7	-0.5	-1.1	-0.5	-0.4	0.8	0.3	1.1	-0.9	0.3	-0.6	-1.3	-0.1	-0.3
Pulse rate, automated reading	0.5	1.7	6.1	1.7	1.2	1.3	1.4	-0.2	2.5	1.3	0.2	1.3	1.0	1.3	0.4	1.1
Alcohol intake frequency.	0.5	1.2	3.8	1.6	1.5	1.2	0.9	-0.8	0.3	0.9	-0.3	1.9	0.0	0.9	-0.1	1.4
Number of full sisters	0.5	0.6	2.0	0.5	0.7	0.8	0.8	-0.7	-0.6	-0.3	1.4	0.8	-0.8	0.6	-0.4	0.9
Diabetes diagnosed by doctor	0.5	0.8	3.0	0.8	1.0	0.9	0.8	0.3	0.7	1.7	-0.0	1.6	0.4	0.2	-0.0	1.1
Hearing aid user	0.5	0.6	1.1	1.0	0.5	0.7	0.5	0.6	1.1	0.7	-0.4	0.7	1.0	0.9	0.9	0.7
Fractured/broken bones in last 5 years	0.5	0.6	1.3	-1.1	-0.8	-0.6	-0.8	-0.6	-0.5	-0.9	-0.9	-0.5	-1.1	-0.5	-0.7	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.2	0.9	0.6	0.3	0.4	1.5	-1.1	0.9	-0.0	0.5	0.9	0.1	0.8	0.6
Heart disease (siblings)	0.5	0.6	1.0	0.9	0.7	0.9	1.0	-1.0	1.0	0.8	0.5	1.0	-0.0	0.9	-0.3	0.7
Alzheimer’s Disease (in father)	0.4	0.4	1.6	0.8	-0.3	0.4	0.6	1.3	-0.4	0.2	-0.4	0.9	0.6	0.2	0.8	0.6
Major Depression (MDD)	0.4	0.5	2.7	0.0	0.0	-1.0	-1.1	0.0	0.0	0.0	0.0	0.0	-1.7	0.0	0.0	-1.4
LDL Cholesterol	0.4	0.7	1.3	-0.7	-0.8	-0.7	-1.1	-1.1	-0.7	-0.8	-1.1	-0.9	-0.3	-0.2	-0.6	-1.0
BMI	0.4	2.2	6.0	1.6	2.4	1.6	1.1	-1.5	1.7	1.6	-0.3	1.9	0.3	1.6	-0.1	1.5
Hand grip strength (left)	0.4	1.0	9.9	0.8	0.2	0.2	-0.2	-0.6	3.1	-0.6	-1.1	-0.1	0.1	0.8	0.5	-0.1
Medication: Co-codamol	0.4	0.4	1.1	1.1	0.9	0.7	0.4	-0.2	0.5	0.0	0.8	0.2	0.7	0.9	0.6	0.5
Relative age voice broke	0.4	0.7	1.1	0.9	1.0	1.0	0.7	0.5	-0.3	0.7	0.0	0.7	1.0	1.1	1.0	0.8
Had menopause	0.4	0.6	3.9	-0.4	-0.7	-0.6	-0.9	-0.0	0.0	-0.7	-2.0	-0.5	0.0	-0.1	-0.2	-0.7
Diabetes (self-reported)	0.4	0.6	2.0	1.0	0.8	0.7	0.6	-0.1	1.1	1.2	-0.3	1.4	0.0	0.3	-0.1	1.0
Time employed in main current job	0.4	0.5	1.8	0.4	0.7	0.6	0.4	-1.3	-0.5	-0.6	1.2	0.1	0.1	0.9	-0.2	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.2	-0.8	-0.1	-0.4	0.1	-0.2	-1.5	-0.0	0.8	0.3	-0.5	-1.0	-1.0	0.0
Medication: Ibuprofen	0.4	0.4	1.2	0.1	0.9	0.7	0.9	0.1	-0.4	0.8	0.8	1.1	-0.1	0.3	-0.1	0.9
Illnesses of siblings: Diabetes	0.4	0.5	1.4	-0.9	-0.8	-0.5	-0.4	-0.8	-0.3	-0.5	0.0	-0.5	-1.2	-0.7	-1.0	-0.6
Mood swings	0.4	0.7	2.9	0.3	-0.5	-0.3	-0.5	-0.7	-1.7	-0.6	0.2	-0.3	-1.6	-0.5	-1.1	-0.2
Long-standing illness, disability or infirmity	0.4	0.6	1.6	0.9	1.2	0.7	0.4	-0.2	0.0	1.3	0.2	1.3	0.4	0.5	-0.1	0.9
Breast cancer (self-reported)	0.4	0.5	1.4	-0.6	-1.0	-0.3	-0.4	-0.5	-1.2	-0.7	-0.9	-0.1	-0.9	-0.4	-0.5	-0.3
Wears glasses or contact lenses	0.4	0.4	1.8	-0.3	-0.2	-0.4	-0.7	-1.0	0.3	-1.2	-1.3	-0.4	0.1	-0.1	-0.4	-0.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.6	0.3	0.3	0.7	0.5	0.9	-0.3	0.6	1.3	0.2	0.8	0.9	0.9	0.5
Age started oral contraceptive pill	0.4	0.4	4.2	0.4	0.2	-0.2	-0.5	-0.2	1.0	-0.2	-2.0	-0.1	-0.1	-0.1	0.2	-0.3
Ever depressed for a whole week	0.4	0.5	1.1	0.8	0.4	0.9	0.9	0.4	0.7	0.8	0.8	1.0	-0.6	0.5	0.1	0.9
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.9	-1.3	-1.4	-1.0	-0.9	0.1	-1.4	-1.2	0.4	-1.7	-1.1	-1.1	-0.4	-1.1
Supplements: Calcium	0.4	0.5	1.8	-1.2	-0.2	-0.2	-0.5	-1.3	0.4	-0.3	-1.1	0.0	-0.7	0.1	-0.7	-0.3
Alcohol drinker status: Previous	0.4	0.4	1.6	0.9	0.4	0.7	0.5	-0.5	1.3	0.4	-0.0	0.7	-0.0	1.1	0.5	0.5
Bipolar Disorder (2018)	0.3	0.5	1.8	-0.3	-0.2	-0.8	-1.1	-0.3	-1.0	0.2	-1.4	-0.6	0.6	-0.4	-0.4	-0.7
Schizophrenia vs Biploar Disorder	0.3	0.4	3.8	0.0	0.0	0.0	2.0	0.3	0.2	0.7	0.0	0.0	0.0	0.0	0.7	0.0
Alzheimer’s Disease (in mother)	0.3	0.4	1.5	0.1	0.6	0.6	0.3	-1.2	0.7	-0.0	-0.2	0.2	0.8	1.2	0.1	0.2
Irritable Bowel Disease (IBD)	0.3	0.6	2.5	0.6	0.4	0.6	0.1	-1.2	1.4	-0.6	0.3	-0.1	0.5	1.6	0.4	0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.5	-1.1	-0.8	-1.0	-0.8	-0.4	0.4	-1.2	-0.6	-1.2	-0.7	-0.8	-0.5	-0.9
Blood Platelet Count	0.3	3.1	5.2	1.7	1.7	2.1	2.2	1.7	-0.5	2.2	2.0	1.8	0.3	1.4	1.5	2.3
Cardiovascular Disease	0.3	0.9	2.4	0.9	1.5	0.9	0.7	-1.2	-0.1	0.2	-1.2	1.4	0.6	0.9	-0.4	0.9
Tanning	0.3	3.4	8.6	-1.0	-2.2	-1.9	-2.2	-1.8	1.0	-1.9	-2.9	-2.0	-0.7	-1.2	-1.2	-2.4
Number of treatments/medications taken	0.3	0.6	1.4	0.8	1.1	0.6	0.0	-0.8	0.8	0.7	-0.6	0.9	1.2	1.1	0.2	0.4
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	2.2	0.1	-0.4	0.2	-0.1	-1.5	-0.6	-1.0	-0.5	0.2	-0.3	0.6	-0.4	-0.1
Ever had hysterectomy (womb removed)	0.3	0.3	1.2	-0.0	-0.4	-0.0	0.4	-0.6	-0.7	-0.7	-1.1	0.6	-0.5	-0.4	-0.9	0.1
Medication for hormone replacement therapy	0.3	0.3	1.2	-0.5	-0.0	-0.5	-0.6	-1.1	0.5	-0.2	0.3	-0.5	-0.2	0.1	-0.8	-0.6
Diabetes (father)	0.3	0.4	1.1	0.7	0.5	0.8	0.7	0.2	-0.6	0.3	-0.4	1.1	-0.6	0.4	-0.1	0.8
Hand grip strength (right)	0.3	0.7	8.1	0.6	0.1	0.2	0.0	-0.4	2.8	-0.3	-0.5	0.1	-0.5	0.5	0.1	0.1
Average weekly fortified wine intake	0.3	0.4	1.4	0.6	0.4	0.3	0.3	-1.1	0.4	-0.3	-1.2	0.3	-0.8	0.0	-0.8	0.2
Serious illness, injury or assault to yourself	0.3	0.4	0.7	-0.4	-0.4	-0.6	-0.8	0.2	-0.8	0.1	0.8	-0.8	-0.8	-0.5	-0.3	-0.6
Medication: Atenolol	0.3	0.4	2.8	-0.5	-0.0	-0.3	-0.3	0.3	-1.7	-0.1	-0.1	0.0	1.1	-0.3	-0.2	0.0
Chronic bronchitis/emphysema (father)	0.3	0.3	1.3	0.5	-0.4	0.1	-0.0	1.1	1.1	0.7	-0.3	0.5	0.5	-0.1	0.7	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.1	-0.7	-0.6	-0.9	-1.0	-0.7	0.3	-0.8	-0.2	-0.8	-0.5	-0.5	-0.7	-0.9
Hearing difficulty/problems with background noise	0.3	0.4	1.9	0.3	0.6	0.2	-0.2	-1.1	1.4	0.2	-0.9	0.5	-0.3	0.5	-0.3	0.1
Forced vital capacity (FVC)	0.3	1.0	3.6	-0.3	0.6	0.9	1.4	1.5	0.8	0.7	1.9	0.5	0.3	0.4	1.1	0.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.9	0.6	0.7	0.6	0.7	0.9	-0.4	0.7	0.9	0.8	0.1	-0.0	0.4	0.8
Heart attack	0.3	0.4	1.1	0.5	1.1	0.5	0.5	0.1	-0.8	0.5	0.3	1.0	0.9	0.0	-0.1	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.4	0.9	1.2	0.6	0.2	-0.9	0.4	0.5	1.1	0.7	0.4	0.7	-0.2	0.6
Pulse rate	0.3	0.6	2.3	1.0	0.6	0.7	0.8	0.0	1.5	1.0	0.4	0.4	0.8	0.6	0.4	0.5
Prospective memory result	0.3	0.4	1.6	0.6	0.5	0.4	0.6	0.7	1.3	0.7	0.7	0.1	0.3	0.1	0.6	0.3
Lung cancer (father)	0.3	0.4	2.3	-0.1	-0.4	-0.4	-0.5	1.5	-0.3	0.2	-0.5	-0.7	1.0	-0.1	0.7	-0.3
Loud music exposure frequency	0.3	0.3	1.2	-0.7	-0.2	-0.4	-0.2	-0.2	0.4	-0.0	1.1	-0.5	-1.0	-0.6	-0.6	-0.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	0.7	0.7	0.7	0.7	0.9	-0.7	0.8	0.5	0.1	0.4	0.3	0.9	0.5
Medication: Paracetamol	0.3	0.5	1.4	1.1	0.6	0.9	0.6	-0.1	-1.0	0.8	-0.4	1.2	-0.2	0.6	-0.1	0.9
Headache pain in last month	0.3	0.6	1.9	1.3	1.2	0.3	-0.1	-1.0	0.2	0.3	-1.4	1.0	-0.1	0.5	-0.4	0.5
Comparative body size at age 10	0.3	0.7	1.2	0.9	0.9	1.1	1.1	-1.1	0.8	0.2	0.6	1.0	-0.4	0.9	-0.3	0.9
Wheeze or whistling in the chest in last year	0.3	0.5	2.5	0.8	1.0	0.4	-0.3	-1.6	0.4	0.2	-0.7	0.6	-0.5	0.9	-0.2	0.3
Medication for pain relief, constipation, heartburn	0.3	0.6	1.5	-1.1	-0.8	-0.9	-0.9	0.6	0.6	-0.7	-0.3	-1.2	-0.3	-0.6	0.1	-0.9
Medication: Omeprazole	0.3	0.4	1.2	0.7	0.4	0.2	0.2	1.1	-0.6	0.6	0.3	0.2	1.1	0.2	0.7	0.4
Overall health rating	0.3	0.6	2.0	-0.2	0.1	-0.3	-0.6	-1.4	-1.0	0.2	-0.5	0.5	-1.0	-0.3	-1.4	-0.2
Age at last live birth	0.3	0.4	1.1	-1.0	-0.3	-0.7	-0.7	0.4	0.8	0.3	-0.3	-1.1	0.3	-0.5	-0.1	-0.8
Family relationship satisfaction	0.3	0.4	1.8	0.2	0.1	-0.3	-0.8	-0.8	0.3	-1.3	-0.9	-0.6	0.1	0.3	-0.0	-0.6
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.8	-0.1	0.5	-0.0	0.1	-0.2	-1.3	-0.8	1.0	-0.1	-0.4	-0.2	-0.3	0.2
Loneliness, isolation	0.3	0.4	1.7	0.8	0.7	0.1	0.1	1.3	-0.8	0.4	0.1	0.2	0.7	-0.3	0.6	0.3
Ever had bowel cancer screening	0.3	0.4	1.0	-0.5	-0.9	-0.2	-0.1	-0.8	0.8	-1.0	-0.9	0.2	-0.5	-0.3	-0.5	-0.3
Eye problems/disorders: Cataract	0.3	0.3	1.3	-0.5	-0.0	-0.1	0.3	0.9	-1.1	0.8	0.3	0.4	-0.0	-0.8	-0.5	0.4
Average weekly champagne plus white wine intake	0.3	0.5	1.5	-0.7	-0.1	-0.6	-0.5	-0.6	-0.7	-0.4	-1.2	-0.5	-0.6	-0.6	-1.0	-0.6
Mother’s age at death	0.3	0.3	1.4	0.1	0.2	0.4	-0.2	-0.7	-1.0	-0.8	-1.2	0.3	0.3	0.7	0.1	0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.7	0.2	0.0	0.3	0.1	0.4	1.3	0.8	0.3	0.4	1.1	0.5	0.7	0.2
Medication: Atorvastatin	0.3	0.4	1.2	0.5	0.7	0.8	0.6	-0.5	-0.0	0.3	0.4	1.1	0.5	0.8	-0.0	0.8
Irritability	0.3	0.6	1.2	0.6	0.1	-0.4	-1.1	-1.0	1.0	-0.9	-0.9	-0.9	0.5	0.6	-0.1	-0.8
Risk taking	0.3	0.4	1.6	-0.1	-0.5	-0.3	-0.6	-0.6	-0.3	-1.3	-0.7	-1.1	-0.3	0.3	0.3	-0.7
Cholesterol lowering medication	0.3	0.4	1.3	0.8	0.8	0.3	-0.0	-0.7	-0.3	0.4	-1.1	0.9	0.5	0.3	-0.4	0.4
Depressed Affect (Nagel 2018)	0.2	0.4	1.4	0.3	-0.1	-0.7	-1.0	-0.5	-0.2	-0.2	-0.3	-0.6	-1.2	-0.6	-1.0	-0.6
Breast Cancer	0.2	0.5	1.8	-0.2	-0.6	-0.8	-0.4	1.1	-1.0	-0.2	0.3	-0.6	0.5	-1.4	0.1	-0.5
Ovarian Cancer	0.2	0.2	0.7	-0.4	-0.4	-0.3	0.3	0.4	-0.7	0.5	0.6	0.1	-0.6	-0.8	-0.4	0.0
Prostate Cancer	0.2	0.3	1.3	-0.5	-0.6	-0.3	-0.4	0.3	-1.1	0.2	-0.5	-0.4	-0.3	-0.7	-0.2	-0.4
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	-0.6	-0.5	-0.4	-0.5	-0.8	0.7	-0.8	-0.8	-0.3	-0.3	-0.1	-0.5	-0.6
Fasting Glucose	0.2	0.2	1.7	0.1	-0.0	-0.3	-0.5	-0.8	1.3	-0.3	0.1	0.3	-0.1	-0.0	-0.3	-0.2
Triglycerides	0.2	0.3	1.7	0.7	0.6	0.5	0.4	-1.3	0.1	-0.1	0.2	-0.6	-0.2	0.7	-0.2	0.2
Blood White Count	0.2	1.8	2.9	1.6	1.6	1.5	1.6	0.6	1.3	1.7	1.1	1.3	0.8	1.3	1.2	1.5
Heel T-Score	0.2	1.5	4.7	-1.7	-1.0	-1.1	-1.0	-0.5	-2.2	-1.4	-0.9	-1.3	-0.8	-1.3	-0.9	-0.9
Systolic Blood Pressure	0.2	1.0	3.1	-1.8	-0.9	-1.1	-0.9	-0.5	-0.7	-0.8	-0.0	-1.0	-1.1	-1.2	-1.1	-0.9
Respiratory disease	0.2	0.4	1.3	-0.0	0.0	0.5	0.5	1.1	0.9	1.0	1.1	0.3	0.0	0.2	0.7	0.4
Sensitivity / hurt feelings	0.2	0.3	1.1	-0.0	-0.2	-0.4	-1.0	-1.0	0.4	-0.2	-0.8	-0.3	-0.4	-0.0	-0.7	-0.7
Vitamin and mineral supplements	0.2	0.3	0.9	-0.2	-0.2	-0.3	0.2	0.8	-0.6	0.8	0.7	0.4	0.1	-1.0	-0.1	0.1
Impedance of leg (right)	0.2	0.8	2.8	-0.2	-0.8	-0.7	-0.6	-0.9	-1.7	-1.6	-1.0	-0.4	-0.5	-0.7	-1.0	-0.7
Current tobacco smoking	0.2	0.3	0.7	0.2	0.8	0.6	0.5	-0.6	-0.2	-0.3	0.6	0.5	-0.4	0.9	-0.1	0.6
Sitting height	0.2	1.5	4.2	0.7	1.0	1.2	1.3	1.3	2.1	1.7	0.1	1.9	-0.6	0.7	0.3	1.5
Medication: Simvastatin	0.2	0.3	1.5	0.5	1.2	0.1	-0.1	-0.5	0.4	0.4	-0.5	0.3	1.2	0.2	0.1	0.1
Fluid intelligence score	0.2	0.5	1.6	-1.1	-0.9	-0.7	-0.5	0.4	0.4	-0.5	0.2	-1.3	-0.6	-0.6	0.1	-0.8
Happiness	0.2	0.2	0.7	0.4	-0.4	-0.0	-0.6	-0.7	0.6	-0.8	-0.4	-0.4	-0.2	0.5	0.1	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.9	0.1	0.6	0.2	0.1	-0.1	-0.9	0.2	-0.5	0.4	-0.6	-0.1	-0.3	0.4
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	0.6	0.9	0.3	-0.1	0.2	0.7	0.6	-0.5	0.4	0.8	0.7	0.4	0.2
Medication: Lansoprazole	0.2	0.2	1.6	0.1	0.4	0.0	-0.3	-0.0	-1.3	-0.1	0.2	-0.0	0.6	0.4	0.2	-0.0
Standing height	0.2	2.0	5.3	1.0	1.1	1.6	1.5	1.6	2.3	1.5	0.5	1.6	-0.1	1.4	1.1	1.7
Breastfed as a baby	0.2	0.3	1.5	0.2	0.3	0.4	0.4	0.1	0.8	0.3	-1.2	0.5	0.4	0.5	0.3	0.3
Hair/balding pattern: Pattern 4	0.2	0.4	1.1	-0.8	-0.3	-0.8	-0.6	-0.7	-0.1	-0.7	0.0	-0.3	-0.8	-0.9	-1.1	-0.5
Birth weight	0.2	0.5	1.4	0.5	0.8	0.6	0.6	-0.8	0.6	0.2	-0.9	1.2	-0.6	0.6	-0.5	0.6
Forced vital capacity (FVC), Best measure	0.2	0.8	4.6	-0.5	0.1	0.6	1.3	1.4	0.6	0.5	2.1	0.2	0.2	0.1	0.9	0.7
Health satisfaction	0.2	0.2	0.5	0.7	0.7	0.4	0.1	-0.6	0.0	0.1	-0.6	0.6	-0.4	0.3	-0.5	0.4
Comparative height size at age 10	0.2	1.1	4.0	0.6	0.3	0.6	0.9	1.8	2.0	1.1	1.4	0.5	-0.6	0.5	0.9	0.8
Suffer from ‘nerves’	0.2	0.3	1.6	-0.2	-0.4	-0.2	-0.2	-1.3	0.1	-0.4	0.4	-0.4	-0.7	-0.1	-0.6	-0.4
Had major operations	0.2	0.2	1.0	0.1	0.3	0.4	0.1	-0.1	0.9	0.1	0.3	-0.3	-0.5	1.0	0.5	0.1
Illnesses of father: Heart disease	0.2	0.2	0.9	-0.6	-0.0	-0.5	-0.2	-0.1	0.2	0.4	0.9	0.0	-0.1	-0.8	-0.8	-0.2
Asthma (self-reported)	0.2	0.3	0.9	-0.7	-0.6	-0.5	-0.6	-0.3	0.4	-0.1	-0.7	-0.5	-1.0	-0.6	-0.4	-0.7
Illnesses of father: None of the above (group 1)	0.2	0.2	1.1	0.0	-0.1	0.4	0.6	-0.2	-0.1	-0.6	1.0	-0.3	-0.7	0.4	0.2	0.2
Smoking status: Current	0.2	0.3	0.8	0.4	0.9	0.7	0.7	0.0	-0.2	0.2	0.9	0.6	-0.2	0.8	0.2	0.7
Number of self-reported non-cancer illnesses	0.2	0.4	2.9	-0.1	0.5	0.2	-0.2	-1.7	-0.6	-0.3	0.0	0.6	-0.3	0.3	-1.0	0.2
Miserableness	0.2	0.3	1.4	0.2	-0.4	-0.4	-0.5	-0.4	-0.1	-0.4	0.2	-0.0	-1.2	-0.6	-0.8	-0.2
Financial situation satisfaction	0.2	0.3	0.5	0.2	0.7	0.5	0.3	0.7	-0.7	0.5	0.4	0.6	0.7	0.4	0.3	0.5
Medication: Blood pressure	0.2	0.4	1.6	0.5	0.2	0.1	-0.1	-0.9	0.9	-0.0	-1.3	0.7	-0.3	0.4	-0.5	0.2
Illnesses of father: High blood pressure	0.2	0.3	2.0	0.4	0.6	0.2	0.0	-0.4	1.4	0.1	-0.1	0.4	0.8	0.5	0.5	0.2
Commuting to job workplace: Cycle	0.2	0.2	0.7	-0.5	-0.4	-0.2	-0.4	0.4	-0.6	-0.9	-0.3	-0.7	0.0	-0.1	0.5	-0.4
Heart attack/myocardial infarction (self-reported)	0.2	0.2	1.5	0.1	0.6	0.1	0.2	0.0	-1.2	0.2	0.2	0.6	0.6	-0.4	-0.4	0.4
Alzheimer’s Disease (including proxy)	0.1	0.1	0.8	-0.2	-0.2	0.1	0.1	0.0	-0.3	-0.4	-0.2	0.1	0.9	0.4	0.2	0.0
Ulcerative Colitis (UC)	0.1	0.2	0.9	-0.4	-0.2	-0.2	-0.2	-0.9	-0.3	-0.7	0.5	-0.3	-0.7	0.2	-0.6	-0.2
HDL Cholesterol	0.1	0.1	0.6	0.1	0.1	-0.0	0.0	0.7	0.1	0.5	-0.5	0.4	0.1	-0.2	0.3	0.1
Lupus	0.1	0.1	0.7	0.2	0.1	0.1	-0.0	-0.6	-0.5	-0.2	0.3	0.1	0.8	0.4	0.1	-0.1
Neuroticism (2016)	0.1	0.2	0.5	0.7	0.1	-0.1	-0.5	-0.2	0.6	-0.1	-0.7	-0.5	0.6	0.4	0.4	-0.3
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	0.0	0.0	0.0	-0.1	0.1	-0.7	0.3	0.6	0.0	-0.1	0.2	-0.0	0.6
Blood Red Count	0.1	0.9	3.3	-1.8	-1.4	-0.7	-0.8	-0.6	1.5	-0.2	-1.1	-0.4	-0.0	-0.3	-0.7	-0.8
Height	0.1	1.8	14.0	0.0	0.0	0.5	0.0	1.6	3.7	1.3	0.1	0.5	0.8	1.4	1.4	0.4
Lung FVC	0.1	0.7	3.1	-1.1	-0.1	0.5	0.9	1.8	0.6	0.5	1.6	0.2	-0.1	0.1	1.0	0.4
Hair Pigment	0.1	3.5	8.8	3.0	2.7	2.0	1.8	0.8	1.6	1.3	1.3	1.4	1.6	2.2	1.7	1.9
Systolic blood pressure, automated reading	0.1	0.3	0.9	-1.0	-0.5	-0.6	-0.6	0.1	0.9	-0.4	-0.2	-0.4	0.5	-0.3	-0.2	-0.5
Townsend deprivation index at recruitment	0.1	0.1	1.1	0.2	-0.1	0.2	0.2	0.1	-0.0	-0.1	1.0	0.1	0.4	0.3	0.3	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	0.6	0.5	-0.0	-0.2	0.5	-0.1	0.5	0.5	-0.1	0.1	-0.0	0.3	0.0
Impedance of leg (left)	0.1	0.7	3.1	0.0	-0.7	-0.5	-0.4	-0.8	-1.8	-1.4	-0.7	-0.3	-0.6	-0.6	-0.9	-0.4
Had other major operations	0.1	0.2	0.6	0.1	0.2	0.5	0.3	-0.3	-0.2	-0.1	-0.7	0.8	-0.1	0.3	0.0	0.5
Impedance of arm (right)	0.1	0.7	6.9	0.3	0.2	-0.2	0.2	0.4	-2.6	-0.1	0.1	0.4	-0.6	-0.9	-0.4	0.3
Father’s age at death	0.1	0.2	1.0	0.0	-0.5	0.1	0.0	-0.3	-0.5	-0.8	-1.0	-0.2	0.1	0.4	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	2.4	-0.4	0.1	0.4	0.8	1.0	0.5	0.2	1.6	0.1	-0.2	-0.1	0.6	0.5
Asthma	0.1	0.2	0.4	-0.4	-0.4	-0.3	-0.5	-0.3	0.7	-0.0	-0.7	-0.3	-0.5	-0.2	-0.1	-0.6
Depression (self-reported)	0.1	0.1	0.7	-0.2	-0.4	-0.1	0.1	0.5	-0.3	-0.1	0.8	-0.0	0.0	-0.4	0.2	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.5	2.9	-0.9	-0.5	0.0	0.7	0.7	0.4	-0.3	1.7	-0.3	-0.6	-0.6	0.1	0.1
Impedance of arm (left)	0.1	0.4	3.9	0.3	0.5	-0.0	0.3	0.3	-2.0	0.0	-0.2	0.5	-0.3	-0.7	-0.3	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.6	-0.1	0.2	0.0	-0.2	-0.5	-0.5	-0.0	0.8	0.1	-0.3	0.1	-0.5	0.0
Peak expiratory flow (PEF)	0.1	0.2	1.0	-0.9	-0.2	0.1	0.2	-0.6	0.3	-0.5	0.6	-0.1	-1.0	-0.2	-0.4	0.0
Worry too long after embarrassment	0.1	0.1	0.4	0.5	-0.3	0.1	-0.3	-0.7	0.1	-0.4	-0.2	-0.1	0.5	0.4	0.1	-0.2
Eye problems/disorders: None of the above	0.1	0.1	0.6	0.1	0.3	0.2	0.3	0.1	-0.8	0.4	-0.6	0.5	-0.2	-0.0	-0.2	0.2
Migraine (self-reported)	0.1	0.1	0.3	0.3	-0.5	0.0	0.3	0.5	-0.4	0.3	0.2	0.4	-0.1	-0.5	-0.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.8	-0.4	-0.4	0.1	0.4	0.5	-0.9	-0.0	0.8	0.3	-0.2	-0.6	-0.4	0.4
Qualifications: nursing, teaching	0.1	0.2	1.5	-0.2	0.2	-0.1	-0.2	1.2	0.5	0.3	-0.5	-0.1	-0.5	-0.3	0.6	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.5	0.2	-0.0	0.4	0.4	0.2	-0.7	0.3	0.7	0.3	-0.2	0.0	0.0	0.5
Mineral and other dietary supplements	0.1	0.2	0.6	0.7	0.2	0.2	0.6	0.6	-0.8	0.1	0.4	0.3	-0.0	-0.2	0.3	0.4
Guilty feelings	0.1	0.1	0.4	0.3	0.1	-0.4	-0.6	0.2	0.0	-0.3	-0.5	-0.6	-0.4	-0.3	-0.0	-0.4
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.4	0.1	-0.2	-0.1	-0.3	-0.5	-0.3	0.5	0.0	0.1	-0.2	-0.4	-0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	-0.1	-0.3	0.3	0.2	0.1	0.1	0.3	0.1	0.6	0.3	0.1	0.1	0.4
Commuting to job workplace: Public transport	0.1	0.1	0.5	-0.2	-0.4	-0.3	-0.1	0.5	-0.1	0.5	0.2	-0.4	-0.7	-0.4	-0.1	-0.3
Alcohol drinker status: Never	0.1	0.1	0.6	0.1	0.3	-0.3	-0.3	0.4	0.7	0.5	-0.1	-0.1	0.5	-0.2	0.2	-0.1
Number of operations (self-reported)	0.1	0.1	0.4	-0.1	0.2	0.3	0.2	0.1	-0.0	0.2	-0.1	0.5	-0.1	0.6	0.3	0.4
Diastolic blood pressure, automated reading	0.1	0.2	1.2	0.2	0.1	0.3	0.4	-0.1	1.1	0.1	0.0	0.7	0.4	0.4	-0.1	0.4
Impedance of whole body	0.1	0.7	4.6	-0.2	-0.5	-0.6	-0.2	-0.3	-2.1	-0.9	-0.5	-0.1	-0.7	-1.1	-1.0	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Lung FEV1/FVC ratio	0.0	0.2	1.4	0.4	-0.2	-0.1	-0.2	-1.2	-0.2	-0.0	-0.5	-0.1	-0.7	-0.2	-0.7	-0.2
Stomach or abdominal pain in last month	0.0	0.0	0.2	0.2	-0.1	0.1	0.1	-0.3	0.3	0.2	-0.3	0.3	-0.4	0.0	-0.2	0.0

Hub : Genes

FEM1A

Models

Trait associations