[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr19:48,525,507-50,909,389

Best TWAS P=6.97e-13 · Best GWAS P=6.96e-12 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CPT1C	0.30	0.20	lasso	4	0.22	1.1e-25	-6.9	7.0	2.3e-12	-0.96	0.00	1.00	TRUE
2	GTEx	Artery Aorta	ALDH16A1	0.35	0.27	lasso	9	0.29	3.1e-16	5.0	5.3	1.5e-07	-0.19	0.96	0.04	FALSE
3	GTEx	Artery Tibial	ALDH16A1	0.26	0.20	lasso	8	0.20	8.5e-16	5.2	5.2	2.4e-07	-0.19	0.96	0.04	FALSE
4	GTEx	Brain Cerebellar Hemisphere	ALDH16A1	0.25	0.06	enet	15	0.15	1.4e-04	5.6	5.7	1.2e-08	-0.26	0.09	0.49	FALSE
5	GTEx	Brain Cerebellum	ALDH16A1	0.71	0.43	lasso	11	0.50	6.8e-17	5.0	6.0	1.5e-09	-0.28	0.96	0.04	FALSE
6	GTEx	Brain Frontal Cortex BA9	ALDH16A1	0.34	0.30	lasso	4	0.31	6.7e-09	5.2	5.4	6.8e-08	-0.19	0.80	0.09	FALSE
7	GTEx	Brain Hypothalamus	ALDH16A1	0.44	0.21	lasso	15	0.31	4.4e-08	4.0	5.2	2.2e-07	-0.26	0.24	0.30	FALSE
8	GTEx	Breast Mammary Tissue	ALDH16A1	0.29	0.19	lasso	10	0.19	4.3e-10	5.2	5.7	1.0e-08	-0.23	0.95	0.05	FALSE
9	GTEx	Breast Mammary Tissue (Male)	ALDH16A1	0.17	0.17	lasso	1	0.12	8.1e-04	5.2	5.2	2.2e-07	-0.18	0.10	0.06	FALSE
10	GTEx	Breast Mammary Tissue (Female)	ALDH16A1	0.28	0.10	lasso	7	0.13	9.4e-05	4.0	5.4	6.4e-08	-0.25	0.22	0.11	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	ALDH16A1	0.43	0.28	lasso	5	0.26	3.3e-09	5.2	5.2	1.5e-07	-0.18	0.95	0.05	FALSE
12	GTEx	Cells Transformed fibroblasts	RASIP1	0.19	0.14	lasso	6	0.20	6.1e-15	4.9	5.2	2.4e-07	0.04	0.01	0.98	TRUE
13	GTEx	Cells Transformed fibroblasts	CPT1C	0.21	0.17	lasso	2	0.16	5.4e-12	-6.9	6.7	1.6e-11	-1.00	0.00	1.00	FALSE
14	GTEx	Colon Sigmoid	ALDH16A1	0.31	0.23	enet	12	0.28	2.6e-10	5.2	5.3	1.1e-07	-0.21	0.92	0.07	FALSE
15	GTEx	Colon Transverse	ALDH16A1	0.47	0.34	enet	16	0.36	5.3e-18	5.2	5.4	7.7e-08	-0.22	0.95	0.05	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	ALDH16A1	0.33	0.25	enet	16	0.31	1.1e-11	5.2	5.5	4.2e-08	-0.21	0.94	0.06	FALSE
17	GTEx	Esophagus Mucosa	PIH1D1	0.25	0.18	lasso	8	0.15	4.7e-10	5.0	5.3	8.7e-08	-0.21	0.96	0.04	FALSE
18	GTEx	Esophagus Muscularis	ALDH16A1	0.31	0.27	enet	11	0.31	1.7e-19	5.2	5.3	1.2e-07	-0.18	0.96	0.04	FALSE
19	GTEx	Heart Atrial Appendage	ALDH16A1	0.29	0.22	lasso	7	0.19	4.4e-09	5.2	5.5	3.7e-08	-0.21	0.96	0.04	FALSE
20	GTEx	Lung	PIH1D1	0.10	0.08	lasso	2	0.05	1.9e-04	5.6	5.6	2.2e-08	-0.19	0.78	0.12	FALSE
21	GTEx	Lung	ALDH16A1	0.33	0.32	lasso	7	0.36	2.6e-28	5.2	5.6	1.9e-08	-0.20	0.95	0.05	FALSE
22	GTEx	Muscle Skeletal	ALDH16A1	0.19	0.19	lasso	5	0.18	1.1e-17	5.2	5.2	2.4e-07	-0.18	0.95	0.05	FALSE
23	GTEx	Ovary	ALDH16A1	0.33	0.21	lasso	3	0.15	1.5e-04	5.2	7.2	7.0e-13	-0.59	0.05	0.71	TRUE
24	GTEx	Prostate	ALDH16A1	0.31	0.28	enet	7	0.27	1.6e-07	5.2	5.2	1.7e-07	-0.18	0.76	0.05	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	ALDH16A1	0.32	0.27	lasso	9	0.25	1.0e-13	5.2	5.4	6.8e-08	-0.22	0.96	0.04	FALSE
26	GTEx	Spleen	ALDH16A1	0.46	0.39	enet	12	0.44	8.0e-13	5.2	5.7	1.6e-08	-0.22	0.95	0.04	FALSE
27	GTEx	Stomach	ALDH16A1	0.26	0.10	lasso	7	0.15	1.4e-07	5.2	5.6	1.9e-08	-0.20	0.91	0.05	FALSE
28	GTEx	Testis	PIH1D1	0.59	0.56	enet	21	0.58	4.1e-31	5.2	-5.5	4.0e-08	0.21	0.95	0.05	FALSE
29	GTEx	Thyroid	ALDH16A1	0.37	0.19	lasso	7	0.34	9.8e-27	5.2	5.8	8.4e-09	-0.25	0.95	0.05	FALSE
30	GTEx	Whole Blood	ALDH16A1	0.11	0.10	lasso	2	0.08	4.3e-08	5.2	5.1	2.9e-07	-0.18	0.96	0.04	FALSE
31	YFS	Blood	IRF3	0.24	0.12	lasso	4	0.13	3.3e-40	-5.1	-5.3	1.1e-07	0.57	0.98	0.02	FALSE
32	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PIH1D1	0.09	0.04	blup	47	0.03	7.7e-03	5.2	5.6	2.2e-08	-0.23	0.01	0.84	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	ALDH16A1	0.08	0.11	enet	7	0.11	7.2e-13	5.2	5.3	8.7e-08	-0.18	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPS11	0.03	0.01	enet	11	0.01	1.5e-02	-2.7	5.2	1.6e-07	-0.18	0.02	0.18	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	ALDH16A1	0.04	0.06	enet	5	0.05	7.1e-06	5.2	5.6	2.6e-08	-0.23	0.01	0.99	FALSE