Hub : Genes

PIH1D1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.2460	0.0540	8.8e-09	0.182	NA	0.133	NA	0.147	2.9e-12	NA	3.3e-09	NA	4.7e-10
2	GTEx	Lung	0.0999	0.0364	1.8e-03	0.079	NA	0.031	NA	0.046	1.2e-06	NA	1.8e-03	NA	1.9e-04
3	GTEx	Muscle Skeletal	0.1019	0.0326	4.0e-04	0.066	NA	0.051	NA	0.047	4.6e-07	NA	8.3e-06	NA	1.8e-05
4	GTEx	Skin Not Sun Exposed Suprapubic	0.2920	0.0660	4.4e-06	0.077	NA	0.067	NA	0.059	5.0e-05	NA	1.5e-04	NA	3.5e-04
5	GTEx	Skin Sun Exposed Lower leg	0.0900	0.0310	1.4e-03	0.080	NA	0.066	NA	0.062	3.7e-07	NA	4.1e-06	NA	6.9e-06
6	GTEx	Testis	0.5850	0.0560	0.0e+00	0.559	NA	0.581	NA	0.558	2.1e-29	NA	4.1e-31	NA	2.6e-29
7	GTEx	Thyroid	0.1420	0.0420	1.1e-04	0.077	NA	0.054	NA	0.071	1.5e-06	NA	5.2e-05	NA	4.2e-06
8	YFS	Blood	0.0871	0.0174	0.0e+00	0.079	0.068	0.077	0.078	0.083	1.8e-24	3.1e-21	5.5e-24	2.9e-24	1.1e-25
9	TCGA	Breast Invasive Carcinoma	0.0489	0.0285	1.7e-03	0.006	0.018	0.012	NA	0.008	1.9e-02	1.2e-04	1.4e-03	NA	8.8e-03
10	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0910	0.0500	6.7e-03	0.036	0.030	0.012	NA	0.015	3.6e-03	7.7e-03	6.4e-02	NA	4.6e-02
11	TCGA	Lung Adenocarcinoma	0.0490	0.0241	3.4e-04	0.013	0.020	0.030	NA	0.020	1.0e-02	1.8e-03	1.7e-04	NA	1.9e-03
12	TCGA	Stomach Adenocarcinoma	0.0560	0.0280	1.0e-03	0.047	0.039	0.021	NA	0.032	2.4e-04	8.3e-04	1.1e-02	NA	2.1e-03
13	TCGA	Thyroid Carcinoma	0.1010	0.0400	5.3e-06	0.062	0.083	0.095	NA	0.081	1.2e-06	1.9e-08	1.5e-09	NA	2.7e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.3	0.5	1.9	-0.0	0.1	0.7	-0.3	0.6	-0.4	0.4	0.5	-1.3	0.2	-1.2	0.1	-1.4
Bipolar Disorder or Schizophrenia	0.2	0.6	2.7	0.0	0.5	-0.3	-0.0	0.3	-0.5	0.2	0.7	-0.9	1.0	-0.8	1.2	-1.6
Depressed Affect (Nagel 2018)	4.2	8.9	18.1	3.0	2.2	2.3	4.3	2.6	-2.5	2.5	2.7	2.8	3.8	3.4	3.0	3.0
Depression (Nagel 2018)	0.4	0.5	2.2	0.5	-0.0	-0.3	1.4	0.4	-0.2	0.3	0.6	0.0	1.5	0.7	1.0	0.4
Intelligence (Savage-Jansen 2018)	2.2	6.8	14.2	-2.6	-3.2	-1.9	-3.0	-2.7	2.7	-2.4	-2.8	-1.4	-2.6	-2.2	-3.8	-1.5
Neuroticism (Nagel 2018)	3.5	8.3	12.4	3.1	2.5	2.7	3.2	2.8	-2.5	2.6	3.3	2.5	3.5	3.1	2.8	2.6
Schizophrenia (2018)	0.2	0.4	2.0	0.0	0.5	-0.9	0.2	-0.1	-0.3	-0.1	0.5	-0.0	1.0	-0.0	1.4	-0.9
Schizophrenia vs Biploar Disorder	1.9	2.5	4.2	-1.8	-1.7	-2.0	0.0	-1.7	1.7	-2.0	-1.7	-0.9	-1.0	-1.6	-1.0	-2.0
Worry (Nagel 2018)	0.2	0.4	1.2	0.7	0.3	0.5	0.7	0.7	-0.3	0.2	1.1	0.6	0.9	0.7	0.4	0.7
Alzheimer’s Disease (in mother)	1.1	1.3	3.6	1.1	0.7	1.3	1.9	1.4	-1.4	1.2	1.4	0.8	0.9	0.6	0.8	0.6
Alzheimer’s Disease (in father)	0.6	0.6	2.0	-0.9	0.0	-0.8	-0.2	-0.7	0.7	-0.8	-0.5	-1.3	-0.4	-0.9	-0.3	-1.4
Alzheimer’s Disease (including proxy)	0.2	0.2	1.2	0.2	0.5	0.0	1.1	0.4	-0.3	0.2	0.6	0.3	0.6	-0.0	0.7	-0.1
Crohns Disease (2017)	0.9	2.1	4.4	-1.7	-1.4	-1.5	-0.1	-1.7	1.9	-1.5	-2.1	-1.5	-0.8	-0.6	-1.8	-0.3
Irritable Bowel Disease (IBD)	0.6	1.3	3.4	-1.4	-1.5	-1.0	-0.3	-1.2	1.7	-1.2	-1.8	-0.9	-0.4	-0.7	-1.0	-0.6
Ulcerative Colitis (UC)	0.3	0.5	1.7	-0.8	-1.3	-0.2	0.1	-0.5	1.0	-0.5	-0.7	-0.7	0.0	-0.9	-0.0	-1.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.4	0.8	1.8	-0.4	-0.9	-1.3	1.2	-0.5	0.6	-0.6	-1.3	0.6	-0.4	-0.1	-0.9	1.4
Verbal and Numeric Reasoning (VNR)	5.7	13.7	18.4	-3.8	-4.3	-3.4	-4.0	-4.0	3.9	-3.6	-4.1	-2.8	-3.8	-3.1	-4.3	-2.5
Breast Cancer	0.3	0.7	2.3	0.9	1.1	0.3	-0.5	0.5	-0.6	0.6	0.5	1.3	0.5	1.5	0.8	0.8
Ovarian Cancer	0.2	0.2	1.1	0.1	-0.1	-0.9	-0.2	-0.1	0.0	-0.0	-0.4	0.8	0.1	0.4	0.1	1.0
Prostate Cancer	0.1	0.1	0.6	-0.2	-0.1	0.8	0.3	0.0	-0.0	0.3	-0.2	0.2	-0.1	0.0	0.1	-0.4
Age at First Birth	0.1	0.2	1.0	0.2	-0.1	0.5	1.0	0.8	-0.2	0.4	0.5	0.3	0.5	0.1	0.2	0.2
Bipolar Disorder (2011)	0.5	0.5	2.9	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.5	0.1	-1.0	0.3	-1.7
Body Mass Index (BMI) (2010)	0.2	0.3	1.1	-0.4	-0.4	-1.0	-0.7	-0.4	0.6	-0.5	-0.2	0.4	-0.5	-0.0	-0.6	-0.1
Coronary Artery Disease (CAD)	0.3	0.4	1.9	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.7	-1.2	-0.9	-1.4	-0.3
Crohns Disease (2012)	1.6	2.6	3.9	-1.7	-1.5	-1.4	-0.6	-1.7	2.0	-1.9	-1.7	-1.1	-1.9	-1.9	-1.8	-1.3
Mean Putamen Volume	0.7	0.8	1.5	-1.0	-0.8	-0.7	-0.8	-1.0	1.1	-1.2	-1.0	-0.7	-0.9	-0.5	-0.4	-0.9
Fasting Glucose	0.1	0.1	0.8	0.3	0.3	-0.2	0.9	0.1	-0.3	0.2	0.3	0.1	-0.0	0.1	0.1	0.3
HbA1C	0.6	0.6	2.2	1.0	0.6	-0.2	0.2	0.0	-0.3	0.3	0.1	1.2	0.7	1.5	0.2	1.4
HDL Cholesterol	0.3	0.5	0.9	-0.7	-0.9	-0.7	-0.7	-0.4	0.3	-0.3	-0.9	-0.8	-0.6	-1.0	-1.0	-0.6
LDL Cholesterol	1.0	1.5	2.7	-1.3	-1.5	-0.3	-0.8	-1.5	1.2	-1.6	-1.5	-1.2	-1.6	-0.8	-1.3	-0.7
Lupus	0.8	1.2	3.1	0.9	1.0	0.3	0.4	0.7	-1.0	0.7	1.0	1.8	1.5	1.4	1.7	0.5
Neuroticism (2016)	0.6	0.9	2.1	0.9	0.8	0.8	1.4	0.9	-0.8	0.4	0.6	0.8	1.1	1.2	0.0	1.5
Primary Biliary Cirrhosis	2.9	4.1	7.6	-2.0	-2.1	-1.7	-1.5	-2.0	2.0	-2.0	-2.2	-1.9	-2.8	-1.9	-2.3	-1.4
Rheumatoid Arthritis	0.8	1.1	4.4	1.0	1.1	0.9	0.4	0.8	-0.9	0.6	0.5	1.8	0.3	2.1	0.3	1.4
Schizophrenia (2014)	0.2	0.5	2.0	0.2	0.8	-0.7	-0.1	0.2	-0.4	0.0	0.6	-0.1	1.1	-0.3	1.4	-1.1
Triglycerides	0.5	0.8	2.1	-0.8	-0.5	0.3	0.1	-0.9	0.8	-1.2	-0.8	-1.0	-1.4	-0.9	-1.2	-0.2
Type 2 Diabetes (T2D) (2012)	0.7	0.8	3.8	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.3	-1.8	-1.2	-2.0	-0.9
Ulcerative Colitis	0.6	0.9	2.4	-1.2	-1.5	-0.6	0.3	-0.8	1.1	-1.1	-1.0	-0.3	-0.3	-0.9	-0.1	-1.6
Blood Eosinophil Count	0.6	5.0	13.5	2.2	2.0	2.0	-0.6	2.1	-1.8	3.0	2.4	1.5	1.8	3.7	2.5	1.9
Blood Platelet Count	0.2	2.4	11.6	-1.0	-1.2	0.7	-1.3	-0.9	1.7	-0.5	-0.8	-1.4	-2.6	-1.4	-3.4	-0.1
Blood Red Count	0.6	5.5	35.2	2.2	0.4	5.9	1.2	2.9	-1.9	2.3	2.1	-0.3	-1.9	1.7	-0.3	1.3
Blood White Count	0.7	5.2	11.3	2.3	2.7	3.0	0.8	2.5	-2.1	2.7	2.8	0.8	1.8	3.4	1.7	1.5
Heel T-Score	0.6	4.9	14.2	-1.8	-2.2	-1.0	-3.8	-1.5	1.6	-1.7	-1.5	-2.3	-2.6	-2.5	-2.6	-2.4
BMI	0.2	1.4	4.5	1.2	1.3	1.8	1.1	1.0	-0.8	1.2	2.1	1.0	0.4	0.2	0.9	-0.7
Height	0.6	11.1	25.4	-3.1	-4.6	-1.5	-2.1	-3.4	4.1	-3.3	-4.1	-0.6	-3.9	-3.2	-5.0	-0.8
Waist Hip Ratio (WHR)	1.2	5.4	17.0	2.3	2.3	4.1	2.6	2.9	-2.3	2.0	3.3	0.6	0.6	1.2	2.1	0.6
Systolic Blood Pressure	0.1	0.6	2.5	0.0	-0.2	0.4	-0.7	0.2	-0.0	0.3	1.2	0.7	0.6	-1.1	1.1	-1.6
Smoking Status	0.3	0.7	3.5	0.6	-0.3	1.0	0.4	0.8	-0.6	0.5	0.6	0.4	1.4	0.4	1.9	-0.4
Allergy or Eczema	0.3	0.7	3.7	-0.2	-0.3	0.7	0.3	-0.3	0.3	-0.1	-1.0	-0.2	-1.4	0.2	-1.9	1.4
Cardiovascular Disease	1.4	4.7	9.9	2.3	1.2	3.1	1.1	2.5	-2.0	2.2	3.0	2.3	2.2	1.3	2.7	0.7
Hypothyroidism (self reported)	10.7	24.6	31.2	5.3	5.6	3.3	4.2	5.0	-5.5	5.0	4.7	5.0	5.6	4.8	5.0	5.0
Respiratory disease	0.2	0.5	0.9	-0.7	-0.2	-0.2	-1.0	-0.5	0.9	-0.9	-0.9	-0.0	-0.9	0.7	-0.8	0.1
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.9	0.4	0.0	0.9	-0.2	0.5	-0.3	0.4	0.1	0.1	-1.0	0.7	-0.6	0.9
Lung FEV1/FVC ratio	0.1	0.4	1.8	-0.1	0.1	-0.2	-0.2	-0.5	-0.0	-0.3	0.2	0.0	1.0	-1.4	1.1	-0.0
Lung FVC	0.1	0.6	1.5	0.7	0.8	0.8	0.8	0.5	-0.3	0.9	0.4	0.6	1.0	1.2	0.7	0.8
Neuroticism	3.1	7.5	11.2	2.6	2.1	2.6	3.3	2.6	-2.5	2.3	2.6	3.0	3.2	3.4	2.4	2.7
Chronotype (morning person)	0.5	1.1	2.1	-1.4	-1.0	-1.1	0.8	-1.2	1.4	-1.2	-1.3	-0.4	-0.8	-0.5	-1.1	-0.8
Hair Pigment	0.0	0.6	3.2	0.3	1.0	0.3	-0.6	-0.0	-0.3	-0.1	0.4	0.1	0.9	1.8	1.1	1.0
Tanning	0.2	2.0	4.1	-1.7	-1.0	-1.8	-2.0	-1.1	1.5	-1.6	-1.1	-1.0	-0.2	-1.6	-0.6	-1.9
Hand grip strength (left)	0.1	0.3	1.7	-0.7	-0.2	-1.3	-0.2	-0.6	0.7	-0.5	-0.6	-0.0	0.0	-0.8	-0.4	-0.2
Number of treatments/medications taken	2.2	4.0	8.1	2.3	1.5	2.8	1.1	2.5	-2.2	2.2	2.5	2.4	1.6	1.1	1.6	1.1
Average weekly spirits intake	0.1	0.1	0.6	0.2	-0.2	0.2	0.3	-0.1	-0.3	0.1	-0.0	-0.3	0.8	0.6	0.5	0.3
Sensitivity / hurt feelings	6.1	10.4	15.1	3.2	2.5	3.2	2.8	3.2	-3.2	3.4	2.9	3.6	3.9	3.4	3.2	3.1
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.7	0.4	0.1	0.4	0.8	0.5	-0.2	0.2	0.7	-0.0	0.8	0.2	0.3	-0.3
Hearing difficulty/problems: Yes	0.3	0.4	2.3	0.8	0.6	0.7	0.0	0.3	-0.3	0.4	0.3	0.9	0.4	0.8	0.1	1.5
Relative age of first facial hair	2.8	5.7	9.1	-2.9	-2.6	-2.8	-0.8	-2.4	3.0	-2.8	-2.9	-0.7	-2.2	-2.2	-2.2	-2.0
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.8	1.0	0.9	1.4	0.9	1.1	-1.3	1.1	1.0	0.8	0.2	0.9	0.6	0.5
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.6	1.2	1.5	1.4	1.0	1.4	-1.4	1.2	1.6	0.7	1.0	0.6	1.2	-0.4
Ever had hysterectomy (womb removed)	0.4	0.4	1.7	0.4	-0.5	0.5	0.7	0.6	-0.4	0.4	0.6	0.5	0.7	0.6	1.3	-0.5
Systolic blood pressure, automated reading	0.3	0.7	3.1	-0.5	-0.4	-0.7	-1.3	-0.6	0.4	-0.4	0.7	0.4	-0.3	-1.6	0.5	-1.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.9	-0.3	-0.5	-0.6	0.9	-0.2	0.3	-0.6	-0.6	0.5	-0.2	0.7	-0.2	-0.1
Angina	5.4	7.0	10.6	2.7	1.5	2.7	2.6	2.6	-2.6	2.9	2.4	2.6	3.2	3.2	3.3	1.6
Medication for hormone replacement therapy	0.7	0.7	2.2	0.8	1.0	1.3	0.3	0.8	-1.1	1.0	1.5	0.2	0.4	-0.6	0.3	-0.6
Vitamin and mineral supplements	0.8	1.1	4.1	-0.6	-1.3	-0.3	-0.4	-0.7	0.8	-1.0	-0.8	-0.2	-2.0	-1.4	-1.7	-0.5
Supplements: Zinc	0.3	0.4	1.3	0.3	0.3	-0.1	-1.2	0.3	-0.0	0.5	0.1	0.7	0.8	0.7	0.7	0.8
Medication: Co-codamol	3.2	3.7	8.9	1.9	1.9	1.8	3.0	1.9	-1.9	1.8	1.8	1.3	1.4	2.1	1.4	2.1
Medication: Metformin	0.3	0.4	1.5	-0.1	-0.8	0.6	-1.2	-0.0	0.2	-0.1	-0.2	-0.3	-1.1	-0.8	-0.8	0.0
Diabetes (father)	0.3	0.4	1.6	0.3	0.5	1.0	1.3	0.6	-0.3	0.2	0.8	0.4	0.4	0.4	-0.4	0.3
Diabetes (mother)	0.6	0.8	2.5	-0.7	-0.8	0.3	-0.5	-0.9	0.7	-0.7	-0.8	-1.0	-1.3	-1.0	-1.6	-0.6
Severe depression (siblings)	1.6	1.8	6.0	1.6	0.9	1.0	0.5	1.4	-1.2	1.1	0.9	2.1	0.5	1.3	0.9	2.4
Pack years adult smoking proportion	0.1	0.1	0.5	-0.2	-0.4	-0.1	0.5	0.2	0.4	-0.6	-0.0	-0.2	0.7	0.1	0.4	-0.3
Impedance of leg (right)	0.1	0.3	1.1	-0.4	-0.5	-0.4	0.4	0.1	-0.1	-0.5	-0.1	-1.0	0.4	-1.0	0.1	-0.2
Leg fat-free mass (left)	0.1	0.4	1.2	0.1	-0.4	1.1	-0.5	-0.3	0.7	0.1	0.2	0.7	-1.1	-0.2	-1.0	-0.0
Trunk fat percentage	0.1	0.3	1.5	0.5	0.1	1.0	0.1	0.4	-0.3	0.3	1.2	0.4	-0.2	-0.4	0.4	-0.3
Hand grip strength (right)	0.5	1.5	3.3	-1.4	-0.7	-1.8	-1.1	-1.3	1.4	-1.0	-1.1	-1.3	-0.6	-1.5	-1.0	-0.8
Townsend deprivation index at recruitment	1.6	2.2	3.6	1.9	1.3	1.9	1.0	1.6	-1.6	1.6	1.7	1.2	1.1	1.2	1.2	1.5
Current tobacco smoking	1.7	2.8	6.3	-1.8	-2.2	-1.6	-0.8	-1.6	1.8	-1.9	-1.7	-0.7	-0.9	-2.0	-0.7	-2.5
Average weekly fortified wine intake	3.2	3.7	7.8	2.0	2.3	2.8	1.3	2.1	-2.3	2.0	2.2	1.1	1.4	1.9	1.6	1.4
Maternal smoking around birth	1.2	1.7	3.8	1.5	1.3	1.5	2.0	1.5	-1.3	1.5	1.3	0.8	1.1	1.1	1.1	0.2
Fed-up feelings	3.8	6.8	9.1	2.8	2.1	2.4	3.0	2.7	-2.5	2.1	2.7	3.0	3.0	2.7	2.5	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.6	0.1	-0.4	-0.7	1.2	0.2	0.1	-0.1	-0.0	0.6	0.9	0.4	0.5	0.3
Relative age voice broke	1.0	1.6	2.7	-1.4	-1.2	-1.5	-0.1	-1.0	1.4	-1.2	-1.1	-1.2	-1.4	-1.6	-1.5	-1.0
Taking other prescription medications	1.1	1.7	4.6	1.6	1.1	1.3	-0.2	1.5	-1.5	1.2	1.1	2.1	0.7	1.4	0.9	1.4
Age when periods started (menarche)	1.2	2.9	6.9	-1.9	-1.4	-2.6	-2.3	-1.4	2.0	-1.7	-1.8	-0.9	-0.8	-1.7	-1.7	-1.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.5	0.1	0.2	0.7	0.5	0.1	-0.3	0.4	0.2	0.2	-0.0	0.4	-0.1	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	5.6	-1.6	-1.4	-0.8	-2.3	-1.4	1.4	-1.3	-1.1	-2.2	-2.0	-2.0	-2.1	-2.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	1.0	-0.0	-0.0	-0.4	0.2	-0.1	0.2	0.0	-0.1	1.0	-0.6	0.2	-0.2	-0.1
Qualifications: CSEs or equivalent	0.1	0.1	0.3	-0.1	-0.3	0.3	-0.3	-0.3	0.2	-0.3	0.2	0.0	-0.5	0.1	-0.3	0.0
Serious illness, injury or assault to yourself	0.2	0.3	1.3	0.0	-0.7	-0.0	-0.7	0.1	-0.0	0.3	0.2	0.1	0.2	-0.8	0.5	-1.1
High blood pressure	0.5	1.3	3.5	1.1	0.4	1.6	1.0	1.3	-0.9	0.9	1.9	1.2	1.2	-0.1	1.5	-0.7
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.6	-0.6	-0.5	0.3	-0.1	-0.6	0.7	-0.4	-1.2	-0.2	-1.0	-0.1	-1.6	0.9
Multivitamins +/- minerals	0.6	0.7	2.9	0.2	1.0	-0.4	-0.2	0.0	-0.3	0.4	-0.0	1.2	1.7	1.2	1.5	0.4
Stomach or abdominal pain in last month	0.6	0.7	1.6	0.8	1.0	1.0	1.1	1.0	-0.8	1.0	1.1	1.3	0.1	0.0	0.0	0.4
Supplements: Glucosamine	1.2	1.5	4.3	0.9	1.3	0.2	-0.2	0.7	-0.7	0.7	0.8	2.1	1.9	1.5	1.4	1.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	1.3	-0.3	-0.3	-0.5	-0.1	-0.2	0.2	0.1	-0.0	-0.7	0.3	-0.6	-0.1	-1.1
Medication: Atenolol	5.4	6.8	14.4	2.8	1.5	2.4	2.1	2.6	-2.4	2.4	2.6	3.8	2.3	2.8	3.0	2.5
Medication: Levothyroxine sodium	7.0	11.8	18.2	3.7	3.6	2.1	2.8	3.4	-3.6	3.4	3.1	4.3	3.8	3.3	3.4	3.7
Sitting height	0.1	0.7	2.7	0.1	-1.6	1.3	-0.4	-0.2	0.7	0.5	-0.7	1.5	-0.1	0.2	-0.5	0.4
Chronic bronchitis/emphysema (father)	0.8	0.9	1.6	-0.9	-1.3	-1.1	-0.5	-1.1	1.0	-0.8	-1.2	-1.0	-0.6	-1.1	-0.7	-0.6
High blood pressure (mother)	0.7	0.9	5.2	-0.9	-0.9	-0.3	-1.2	-0.4	0.6	-0.4	-0.1	-0.2	-0.5	-1.6	-0.5	-2.3
Body mass index (BMI)	0.5	2.3	5.8	1.7	1.6	1.9	0.8	1.3	-1.4	1.6	2.4	1.7	1.0	1.1	1.6	0.4
Impedance of leg (left)	0.1	0.4	1.1	-0.7	-0.8	-0.9	0.1	-0.2	0.2	-0.8	-0.5	-0.9	0.4	-1.0	0.0	-0.2
Leg predicted mass (left)	0.1	0.4	1.3	0.1	-0.3	1.1	-0.5	-0.2	0.7	0.2	0.2	0.7	-1.0	-0.1	-0.9	0.0
Trunk fat mass	0.1	0.6	2.3	0.8	0.4	1.5	0.2	0.6	-0.4	0.7	1.5	1.1	0.0	-0.1	0.4	0.1
Waist circumference	0.9	3.3	9.2	2.0	1.7	3.0	1.4	1.9	-1.7	1.8	2.8	1.8	0.5	1.2	1.5	0.5
Number of incorrect matches in round	0.7	1.2	2.5	0.9	1.1	0.9	1.1	0.8	-1.2	0.6	0.9	0.9	1.6	0.9	1.6	1.1
Past tobacco smoking	0.9	1.6	4.7	-1.4	-0.7	-2.2	-0.7	-1.4	1.2	-1.4	-1.4	-0.6	-1.2	-1.5	-1.4	-0.5
Alcohol usually taken with meals	0.6	1.0	2.3	-1.1	-1.0	-1.0	-1.0	-1.5	0.9	-1.0	-1.5	-1.2	-0.7	0.3	-0.7	0.3
Nervous feelings	0.1	0.1	0.4	-0.5	-0.5	-0.1	-0.5	-0.2	0.3	-0.6	-0.1	-0.5	-0.1	0.0	-0.2	-0.2
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	5.5	1.9	1.6	1.8	1.2	2.2	-1.6	1.5	1.8	2.3	2.0	1.5	1.2	1.8
Hearing difficulty/problems with background noise	1.0	1.5	2.7	1.3	1.6	1.5	1.4	1.1	-1.2	1.3	1.2	0.6	1.0	1.2	0.7	1.6
Hair/balding pattern: Pattern 2	1.3	1.6	4.7	-1.4	-0.9	-1.4	0.1	-1.2	1.5	-1.3	-0.8	-2.2	-0.2	-1.7	-0.8	-1.4
Had menopause	1.8	2.2	4.1	1.6	1.3	1.1	0.4	1.4	-1.5	1.3	1.3	1.5	2.0	1.6	1.9	1.6
Had other major operations	6.3	7.7	10.9	2.9	3.1	3.2	1.9	3.3	-3.2	3.3	3.1	1.5	2.7	2.4	3.1	1.3
Forced vital capacity (FVC)	0.4	1.7	4.1	-1.2	-1.4	-0.3	-1.1	-1.2	1.7	-0.8	-1.6	-1.3	-1.4	-1.1	-2.0	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.0	6.4	-1.8	-1.7	-1.3	-2.5	-1.7	1.7	-1.8	-1.3	-2.1	-2.1	-2.4	-2.5	-2.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.5	-0.2	-0.6	-0.4	-0.0	-0.4	0.5	-0.2	-0.5	0.4	-0.2	0.7	-0.2	-0.1
Qualifications: None of the above	0.3	0.6	1.9	-0.7	-0.6	-1.4	0.7	-0.7	0.9	-1.4	-0.8	-0.7	0.0	-0.1	-0.2	-0.6
Financial difficulties in last 2 years	0.3	0.4	1.1	-0.8	-0.5	-0.7	0.1	-0.5	0.8	-1.1	-0.6	-0.2	-0.1	-0.6	-0.0	-0.9
Mouth/teeth dental problems	0.1	0.1	0.6	-0.2	0.0	0.4	-0.1	-0.3	-0.0	0.2	-0.1	-0.1	-0.6	-0.5	-0.8	-0.6
Heart attack	2.2	2.9	6.3	1.7	1.0	1.7	0.9	1.7	-1.5	1.8	1.6	1.8	1.9	2.5	1.9	1.3
Allergy	0.7	1.6	6.2	1.2	0.9	0.2	0.6	1.1	-1.3	1.1	1.8	0.4	2.0	0.2	2.5	-0.7
Pain all over the body in last month	0.1	0.1	0.3	0.2	-0.1	0.2	0.4	0.2	-0.2	0.1	0.1	0.4	-0.5	0.5	-0.0	0.4
Diabetes (self-reported)	0.2	0.3	0.7	0.5	0.3	0.8	-0.2	0.6	-0.6	0.5	0.5	0.7	-0.2	0.7	0.2	0.6
Hayfever/allergic rhinitis (self-reported)	3.1	4.1	8.2	-2.2	-1.8	-1.0	-2.8	-1.6	1.9	-1.7	-2.0	-1.6	-2.3	-1.8	-2.9	-2.0
Medication: Ramipril	1.9	2.4	4.6	1.8	0.9	2.1	1.5	2.0	-1.7	1.9	1.9	1.1	1.4	0.8	1.3	0.9
Medication: Simvastatin	0.6	0.9	3.5	0.9	0.5	1.9	0.9	1.0	-0.9	1.1	1.1	0.5	0.3	-0.1	1.0	-0.8
Fluid intelligence score	3.8	7.8	12.5	-2.9	-2.8	-2.1	-3.5	-2.9	2.8	-2.4	-3.1	-2.7	-2.8	-2.6	-3.5	-1.7
Illnesses of siblings	1.9	2.6	4.4	-1.9	-1.2	-2.1	-1.2	-1.9	2.1	-1.7	-2.0	-1.4	-1.2	-1.2	-1.7	-0.8
Neuroticism score	4.4	9.2	14.8	3.0	2.7	2.8	2.9	3.0	-2.8	2.7	3.2	3.1	3.9	3.4	3.2	2.7
Weight	0.2	0.8	3.4	1.0	0.4	1.8	0.3	0.6	-0.4	1.0	1.4	1.6	-0.0	0.3	0.2	0.4
Impedance of arm (right)	1.0	4.7	7.9	-2.1	-2.6	-1.8	-1.5	-1.8	1.9	-2.2	-2.4	-2.8	-2.3	-2.4	-2.5	-1.5
Arm fat percentage (right)	0.3	1.3	4.3	1.3	1.1	1.8	0.5	1.1	-1.1	1.2	2.1	1.0	0.4	0.4	1.1	0.1
Trunk fat-free mass	0.2	1.2	4.3	1.2	0.7	2.1	0.5	0.7	-0.5	1.3	1.1	1.9	0.5	0.7	0.2	1.1
Hip circumference	0.1	0.5	1.4	0.8	0.3	1.2	-0.3	0.4	-0.4	0.8	1.1	1.2	-0.2	0.5	0.1	0.4
Time employed in main current job	0.4	0.4	1.1	0.7	0.4	0.7	0.3	1.0	-1.0	1.0	0.6	-0.2	0.1	-0.8	0.4	-0.6
Alcohol intake versus 10 years previously	0.1	0.2	0.5	-0.4	-0.7	-0.7	0.2	-0.1	0.4	-0.5	-0.3	-0.2	-0.2	-0.1	-0.3	-0.1
Father’s age at death	0.2	0.3	1.4	0.3	0.7	-0.2	-0.3	0.1	-0.5	0.8	0.1	1.2	0.4	0.2	0.2	0.6
Worrier / anxious feelings	3.5	6.6	12.0	2.6	2.4	3.5	1.9	2.9	-2.8	2.5	2.7	2.4	2.7	2.5	2.0	2.1
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	4.9	1.4	0.2	1.6	0.5	1.2	-1.1	0.8	0.8	2.2	1.0	1.7	0.4	2.0
Falls in the last year	2.9	3.9	7.1	2.1	1.8	1.7	1.6	2.1	-2.0	1.9	1.8	1.8	1.9	2.7	2.6	1.4
Hair/balding pattern: Pattern 3	0.2	0.2	0.5	0.4	0.3	0.7	-0.6	0.4	-0.7	0.5	0.4	0.1	0.6	0.5	0.5	-0.5
Number of live births	0.2	0.2	1.2	0.4	0.6	0.8	0.3	0.3	-0.3	-0.0	0.2	-1.1	-0.6	0.5	-0.2	0.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	4.6	-1.5	-1.5	-0.8	-1.5	-1.5	1.8	-1.1	-1.7	-1.9	-1.4	-2.0	-2.2	-0.8
Pulse rate	0.2	0.3	1.3	-0.6	-0.5	-0.7	0.2	-0.6	0.5	0.1	-0.3	1.2	0.4	0.7	-0.0	0.5
Happiness	0.8	1.0	2.3	1.0	0.8	1.5	1.0	1.2	-0.7	0.8	1.0	1.1	1.2	0.3	0.6	0.8
Noisy workplace	0.1	0.1	0.2	-0.3	-0.4	-0.3	0.4	-0.1	0.2	-0.3	-0.4	-0.3	0.5	-0.4	-0.4	0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.4	-0.3	-0.7	0.8	-1.5	-0.2	0.1	0.0	-0.3	-1.0	-0.6	-1.1	-1.0	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.4	3.3	-1.2	-0.9	-0.5	-0.6	-1.0	0.9	-0.8	-1.1	-1.8	-1.7	-1.6	-1.5	-1.1
Mouth/teeth dental problems: Dentures	0.3	0.6	1.7	0.9	0.3	0.6	0.8	0.6	-0.6	0.5	0.5	1.1	0.1	1.1	0.4	1.3
Asthma	0.8	1.7	3.5	-1.5	-1.0	-0.7	-0.9	-1.2	1.5	-1.6	-1.6	-1.0	-1.9	0.1	-1.8	-0.6
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	8.0	1.8	2.1	2.8	1.4	1.9	-1.9	2.1	2.3	0.5	0.5	0.2	0.2	1.0
Medication: Cholesterol lowering	0.3	0.4	1.1	0.7	-0.0	1.0	-0.1	0.9	-0.6	0.9	0.6	-0.1	0.9	0.2	1.0	-0.2
Depression (self-reported)	0.2	0.3	1.3	-0.3	-0.3	-0.3	1.1	-0.1	0.3	-0.4	0.0	0.3	-0.5	-0.6	-0.8	-0.2
Medication: Lansoprazole	0.9	1.0	1.7	1.2	1.0	0.5	1.3	1.1	-1.3	1.0	1.1	1.1	0.6	0.9	0.8	0.7
Prospective memory result	1.0	1.2	2.0	1.2	1.1	0.5	1.4	1.0	-1.3	1.1	1.3	0.6	1.0	1.0	1.3	0.9
Lung cancer (father)	0.4	0.5	2.9	0.6	0.6	0.5	1.7	0.7	-0.6	0.6	0.6	0.4	0.4	0.7	0.4	0.0
Illnesses of mother	1.0	1.3	3.3	-1.1	-0.4	-1.2	0.0	-1.4	1.4	-1.4	-1.8	-1.4	-1.1	0.1	-0.9	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	3.4	-1.2	-0.9	-0.7	-1.3	-1.2	1.5	-0.8	-1.3	-1.1	-0.7	-1.8	-1.3	-0.8
Pulse wave Arterial Stiffness index	0.0	0.1	0.2	-0.2	0.1	-0.2	-0.1	-0.4	0.4	0.1	-0.0	0.2	-0.2	0.3	-0.2	0.1
Impedance of arm (left)	1.4	6.7	11.2	-2.6	-2.9	-2.3	-1.9	-2.2	2.3	-2.6	-2.7	-3.3	-2.7	-2.9	-2.7	-2.1
Arm fat mass (right)	0.2	0.9	3.1	1.1	0.8	1.7	0.4	0.8	-0.7	1.0	1.8	1.1	0.0	0.3	0.6	-0.0
Trunk predicted mass	0.2	1.3	4.5	1.2	0.7	2.1	0.6	0.8	-0.5	1.3	1.1	1.9	0.5	0.8	0.2	1.1
Standing height	0.3	3.3	7.9	-1.6	-2.8	-0.1	-1.2	-1.6	2.2	-1.5	-2.1	-0.3	-2.2	-1.9	-2.8	-0.5
Length of working week for main job	1.5	1.7	5.4	1.0	1.2	1.0	2.3	1.5	-1.2	1.1	1.0	0.4	1.5	1.4	1.6	0.6
Exposure to tobacco smoke at home	0.3	0.3	1.3	0.4	0.1	-0.5	1.0	0.2	0.1	-0.0	-0.1	0.2	0.7	1.1	0.9	0.5
Breastfed as a baby	0.4	0.5	1.2	0.8	0.8	1.1	0.2	0.8	-1.1	0.9	0.7	0.3	0.5	0.3	0.6	0.4
Tense / ‘highly strung’	1.6	2.6	6.7	1.5	1.6	1.1	1.0	1.7	-1.5	1.4	1.9	1.9	2.6	0.9	1.9	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	3.6	1.6	0.9	1.4	1.6	1.6	-1.5	1.1	1.8	1.5	1.9	1.3	1.7	0.9
Hair/balding pattern: Pattern 4	0.7	1.6	4.2	1.3	1.0	1.4	0.5	1.2	-1.1	1.1	1.0	1.8	0.1	1.9	-0.2	2.0
Birth weight of first child	0.1	0.2	0.5	-0.2	0.6	-0.6	0.2	-0.2	0.1	0.0	0.1	0.6	0.4	0.7	0.5	0.2
Peak expiratory flow (PEF)	1.1	2.6	7.8	-1.3	-2.0	-0.2	-1.6	-1.2	1.3	-0.9	-1.3	-1.7	-1.6	-2.8	-2.2	-1.0
Pulse wave reflection index	0.6	0.8	1.6	-0.9	-0.8	-0.3	-0.3	-1.0	0.9	-1.1	-0.7	-1.3	-0.8	-0.6	-0.8	-1.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.8	-0.1	0.1	-0.1	-0.2	-0.1	0.2	-0.2	-0.2	0.6	0.4	0.2	-0.9	0.6
Loud music exposure frequency	1.0	1.1	2.2	-1.3	-1.1	-1.2	-0.4	-1.2	1.1	-1.0	-1.3	-0.3	-1.1	-1.0	-1.5	-0.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	2.2	0.6	0.6	1.5	-0.5	0.6	-0.6	0.8	0.7	-0.7	-0.5	0.1	0.0	0.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.3	-0.7	-1.1	-0.8	-0.7	-0.4	0.6	-0.8	-0.6	-0.6	-0.1	-1.1	-0.1	-0.7
Blood clot in the leg (DVT)	0.3	0.4	1.7	0.2	-0.2	-0.1	-0.9	-0.5	0.3	0.1	-0.4	0.0	-1.1	0.5	-1.3	0.9
Medication: Paracetamol	1.6	2.7	4.2	1.9	1.8	1.3	0.6	1.6	-1.8	2.0	1.5	1.6	1.9	1.5	1.4	1.6
Headache pain in last month	1.3	2.2	5.4	1.6	0.6	2.2	2.3	1.8	-1.6	2.0	1.6	1.2	0.5	0.3	0.3	1.2
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	6.0	-1.9	-1.4	-2.1	-1.3	-2.2	2.0	-2.1	-2.1	-0.6	-2.0	-0.6	-2.5	0.3
Glaucoma (self-reported)	2.4	2.8	7.6	-1.6	-1.5	-2.4	-2.8	-2.0	1.7	-1.8	-2.2	-0.0	-1.5	0.1	-0.6	-0.2
Gout (self-reported)	0.4	0.6	1.4	0.5	0.8	1.2	-0.8	0.7	-0.6	0.6	1.1	-0.6	0.7	-0.2	0.7	-1.1
Hypothyroidism/myxoedema (self-reported)	9.3	18.2	23.6	4.5	4.9	2.7	3.4	4.3	-4.6	4.1	3.8	4.8	4.8	4.3	4.5	4.2
Medication: Amlodipine	0.4	0.6	4.2	0.0	-0.0	0.5	0.5	0.6	-0.2	-0.0	0.7	-0.3	-0.7	-0.9	0.3	-2.0
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.3	-0.3	-0.6	-1.1	-0.7	-0.9	0.7	-0.7	-1.0	1.0	0.1	1.0	0.0	1.0
Birth weight	0.1	0.2	1.6	-0.0	0.6	-0.1	0.1	-0.4	0.4	-0.3	0.1	-0.3	-0.2	-1.3	-0.5	0.3
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.2	0.2	0.1	-0.5	-1.1	0.1	0.1	0.0	0.3	0.2	1.0	-0.1	0.9	0.6
High blood pressure (siblings)	0.5	0.7	3.0	0.7	-0.0	1.7	0.1	1.0	-1.0	0.8	1.5	0.2	-0.1	-0.3	0.7	-0.7
Forced vital capacity (FVC), Best measure	0.5	1.7	2.8	-1.3	-1.1	-0.5	-1.2	-1.2	1.7	-1.0	-1.5	-1.3	-1.2	-1.6	-1.7	-1.0
Body fat percentage	0.3	1.1	3.9	1.1	0.9	1.6	0.6	1.0	-1.0	1.0	2.0	1.1	0.4	0.1	1.0	0.1
Leg fat percentage (right)	1.3	4.6	10.4	2.4	2.1	2.9	1.2	2.2	-2.2	2.1	3.2	2.3	1.7	1.0	2.1	1.1
Arm fat-free mass (right)	0.2	0.8	3.3	0.8	0.6	1.6	0.3	0.5	-0.2	0.9	0.9	1.8	0.3	0.7	0.2	0.9
Exposure to tobacco smoke outside home	0.5	0.6	1.7	-0.9	-0.9	0.3	-0.9	-0.6	0.8	-0.7	-0.7	-0.8	-1.3	-0.6	-1.1	-0.3
Comparative body size at age 10	0.8	2.3	4.8	-1.3	-1.8	-0.4	-2.1	-1.5	1.5	-1.6	-1.5	-0.6	-1.8	-2.2	-1.8	-0.6
Number of full brothers	1.1	1.4	2.4	-1.3	-1.1	-1.1	-1.3	-1.4	1.0	-1.3	-1.5	-1.5	-1.1	-0.5	-0.9	-0.9
Worry too long after embarrassment	1.3	2.2	3.8	1.4	1.6	1.9	-0.0	1.8	-1.5	1.5	1.4	0.7	1.9	1.6	1.0	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	2.4	1.5	1.1	1.3	1.6	1.4	-1.3	1.4	1.4	1.2	1.1	1.3	1.4	1.4
Wheeze or whistling in the chest in last year	1.5	2.7	5.9	-1.8	-2.1	-1.3	-1.1	-1.8	1.8	-2.0	-2.0	-0.6	-2.4	-0.4	-1.9	-0.7
Number of children fathered	0.3	0.4	1.1	0.1	0.2	0.4	0.4	0.6	-0.3	0.2	0.6	-1.0	0.6	-0.4	0.9	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.0	5.5	1.6	1.8	1.7	2.2	1.7	-1.7	1.9	2.0	0.7	1.9	1.2	2.4	0.7
Age at first live birth	1.1	1.9	3.9	-1.4	-1.1	-1.4	-1.4	-1.3	1.3	-1.0	-1.0	-1.8	-0.9	-2.0	-1.8	-1.1
Pulse wave peak to peak time	0.0	0.0	0.2	0.2	-0.2	0.2	-0.0	0.3	-0.3	-0.1	-0.1	-0.2	0.1	-0.4	-0.1	-0.1
Health satisfaction	0.2	0.3	1.2	0.2	-0.1	0.8	-0.5	0.3	0.0	0.2	0.4	0.7	1.1	0.4	0.8	0.1
Shortness of breath walking on level ground	0.3	0.4	1.6	0.5	0.3	1.0	-0.4	0.5	-0.1	0.1	0.2	1.1	0.2	1.2	0.3	0.6
Qualifications: College or University degree	1.4	4.3	7.2	-2.0	-2.2	-1.4	-2.2	-1.8	1.8	-1.3	-1.9	-2.4	-1.9	-2.6	-2.7	-2.2
Eye problems/disorders: None of the above	0.3	0.3	1.2	-0.6	-0.4	-0.1	-0.4	-0.5	0.5	-0.2	-0.4	-0.3	-0.8	-1.0	-0.2	-1.1
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.2	0.8	0.9	0.5	0.8	0.9	-0.8	0.7	0.7	1.5	0.9	1.2	1.4	1.2
Emphysema/chronic bronchitis	1.1	1.2	2.6	1.3	0.8	1.4	0.7	1.6	-1.0	1.0	0.8	1.2	0.6	1.1	0.1	1.6
Medication for pain relief, constipation, heartburn	2.7	4.6	8.8	-2.4	-2.0	-3.0	-1.4	-2.5	2.4	-2.7	-2.3	-2.1	-1.8	-1.7	-1.4	-1.5
Neck or shoulder pain in last month	4.0	5.7	9.0	2.6	2.0	1.8	1.4	2.1	-2.2	2.6	2.0	2.5	3.0	2.8	2.7	2.8
Medication: Blood pressure	1.4	2.4	4.6	1.6	1.2	1.3	2.1	1.7	-1.6	1.6	1.8	0.9	1.9	0.8	2.1	-0.3
Angina (self-reported)	5.6	7.4	11.2	2.8	1.5	2.8	2.5	2.6	-2.7	2.9	2.5	2.8	3.3	3.3	3.3	1.9
Migraine (self-reported)	3.7	4.6	10.7	2.2	2.0	2.1	3.3	2.1	-2.2	2.3	2.5	1.9	1.8	1.5	1.7	1.6
Medication: Ibuprofen	1.8	2.2	6.9	1.6	1.5	2.6	1.2	1.8	-1.6	1.8	2.0	0.9	0.5	0.4	0.3	0.6
Medication: Allopurinol	0.6	0.8	1.8	1.0	1.2	1.4	-0.8	1.0	-1.0	0.7	1.1	0.4	1.1	0.3	1.0	0.1
Medication: Omeprazole	0.6	0.8	2.2	0.7	0.9	1.1	1.3	0.7	-0.7	0.5	0.9	0.9	0.4	1.5	0.9	0.2
Medication: Seretide 50 evohaler	0.2	0.2	1.5	-0.1	0.4	0.0	0.4	-0.2	0.1	-0.4	-0.2	-0.0	0.7	1.2	0.5	0.1
Mean time to correctly identify matches	0.3	0.5	1.3	-0.4	-1.0	-1.0	1.1	-0.5	0.5	-0.4	-1.0	0.8	-0.5	0.0	-0.4	0.9
Heart disease (mother)	0.7	0.9	2.5	0.9	0.4	1.6	0.1	0.9	-1.3	1.2	1.2	0.9	0.6	0.6	0.9	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.7	0.5	0.2	0.6	-0.3	0.3	-0.8	0.7	0.6	-0.7	0.1	-0.1	0.7	0.6
Whole body fat mass	0.2	0.7	2.9	0.9	0.6	1.6	0.3	0.7	-0.5	0.8	1.7	1.1	-0.1	-0.1	0.4	-0.1
Leg fat mass (right)	0.4	1.5	4.7	1.4	1.0	2.1	0.7	1.2	-1.0	1.2	2.2	1.5	0.5	0.3	0.9	0.2
Arm predicted mass (right)	0.2	1.2	4.2	1.0	0.8	1.8	0.5	0.7	-0.4	1.2	1.1	2.1	0.7	1.0	0.5	1.0
Pulse rate, automated reading	0.1	0.3	1.5	0.1	0.1	-0.6	0.5	-0.1	-0.4	0.5	0.4	1.2	0.5	0.8	0.7	0.2
Alcohol intake frequency.	0.2	0.4	1.4	0.3	-0.8	0.4	0.1	-0.3	0.0	-0.1	-0.4	1.1	-0.3	0.9	-0.5	1.2
Comparative height size at age 10	0.2	1.1	4.1	-0.5	-1.8	0.8	-1.0	-0.8	1.0	-0.6	-1.3	-0.1	-1.2	-0.6	-2.0	-0.1
Number of full sisters	0.8	0.9	2.7	-0.8	-0.9	-0.8	-1.6	-0.8	0.9	-1.0	-0.9	-0.5	-0.7	-1.2	-1.3	0.5
Suffer from ‘nerves’	1.4	2.3	4.1	-1.6	-1.5	-2.0	-1.4	-1.7	1.8	-1.6	-1.4	-1.3	-1.0	-1.3	-1.6	-1.1
Overall health rating	1.3	2.7	8.8	1.7	0.6	1.6	0.6	1.3	-1.1	1.1	1.1	3.0	1.1	2.1	1.1	2.8
Chest pain or discomfort	0.2	0.3	1.1	-0.3	-1.0	0.1	0.3	-0.4	0.4	-0.5	-0.6	0.8	-0.6	0.4	-0.7	0.4
Had major operations	3.7	4.3	8.9	2.1	2.3	1.7	0.9	1.9	-2.0	2.1	1.6	2.3	2.3	3.0	2.1	2.0
Age at last live birth	2.5	3.6	6.8	-2.1	-1.6	-1.5	-0.8	-1.5	1.8	-1.4	-1.3	-2.6	-2.1	-2.4	-2.4	-2.1
Family relationship satisfaction	0.3	0.3	0.9	-0.4	-0.4	-0.8	-1.0	-0.7	0.7	-0.5	-0.9	0.3	0.3	0.1	0.1	-0.2
Leg pain on walking	1.0	1.3	3.8	1.4	0.8	2.0	-0.6	1.3	-1.1	1.2	1.0	0.9	0.5	1.2	0.8	1.1
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	4.3	1.6	1.7	1.1	0.7	1.3	-1.3	1.4	1.7	1.1	2.1	1.6	1.5	1.7
Commuting to job workplace: Car/motor vehicle	1.1	1.2	3.9	-0.7	-0.3	-0.4	-1.7	-0.7	0.7	-0.5	0.0	-1.7	-1.2	-1.2	-1.3	-2.0
Illness, injury, bereavement, stress in last 2 years	2.9	3.5	7.1	1.9	1.5	2.0	1.7	1.6	-1.8	1.7	1.3	1.9	1.6	2.7	1.5	2.7
Medication: Aspirin	0.7	0.9	2.5	1.1	0.1	1.2	-0.3	1.0	-0.9	1.2	0.7	1.6	0.6	1.1	0.6	0.6
Supplements: Vitamin C	3.8	4.4	6.5	-2.4	-2.1	-2.0	-2.0	-2.1	2.3	-2.2	-1.8	-2.6	-2.0	-1.9	-1.6	-2.2
Knee pain experienced in last month	2.6	4.0	7.6	2.0	2.2	1.3	1.2	1.9	-1.7	1.5	1.7	2.3	2.5	2.2	1.9	2.8
Hypertension (Self-reported)	0.7	2.0	5.0	1.4	0.8	1.9	1.2	1.6	-1.3	1.2	2.2	1.4	1.5	0.1	1.9	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	4.0	1.1	0.8	2.0	1.0	1.5	-1.1	1.3	1.3	0.2	0.5	0.3	0.3	0.2
Illnesses of father: Heart disease	2.9	4.0	10.7	2.2	1.0	3.3	1.6	2.3	-2.0	2.5	2.3	1.7	1.4	2.0	1.6	0.7
Illnesses of siblings: Diabetes	1.9	2.3	5.3	1.7	1.3	2.3	1.2	1.6	-1.9	1.3	1.6	1.8	1.0	1.3	1.2	1.0
Smoking status: Previous	2.1	3.2	6.0	2.0	1.6	2.4	0.9	1.8	-1.9	1.9	2.0	1.0	1.4	2.3	1.7	1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.4	-1.1	-1.4	-0.4	-1.8	-1.1	1.5	-1.0	-1.1	-0.2	-1.2	-1.6	-1.7	-0.5
Whole body fat-free mass	0.1	0.6	2.8	0.7	0.3	1.7	0.1	0.3	0.0	0.8	0.7	1.4	-0.1	0.4	-0.2	0.6
Leg fat-free mass (right)	0.1	0.5	1.5	-0.2	-0.7	0.7	-0.7	-0.6	1.0	-0.2	-0.2	0.5	-1.2	-0.2	-1.1	-0.2
Arm fat percentage (left)	0.3	1.0	3.6	1.1	1.1	1.5	0.3	1.0	-0.9	1.1	1.9	0.9	0.2	0.4	1.0	0.1
Average weekly red wine intake	2.2	3.2	6.5	-2.1	-1.9	-1.0	-2.0	-1.5	1.6	-1.8	-1.5	-2.1	-1.8	-1.6	-1.5	-2.5
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.7	1.0	1.4	0.8	0.6	0.8	-0.7	0.7	0.8	0.6	0.9	1.3	1.0	1.6
Mood swings	2.0	3.5	10.8	1.9	1.9	1.7	3.3	1.9	-1.6	1.4	2.1	1.5	2.2	1.4	1.5	1.1
Loneliness, isolation	2.6	3.5	7.7	2.0	1.5	1.7	2.8	1.6	-1.6	1.8	1.8	1.3	2.5	1.9	2.1	1.3
Long-standing illness, disability or infirmity	0.8	1.2	3.0	1.2	0.6	1.7	0.3	0.9	-1.1	1.0	1.0	1.7	0.2	1.4	0.5	1.2
Ever had bowel cancer screening	0.3	0.4	1.6	0.6	0.5	-0.4	0.4	0.2	-0.7	0.5	0.1	1.1	0.3	1.3	0.6	0.6
Diabetes diagnosed by doctor	0.1	0.2	0.9	0.2	-0.4	0.6	-0.4	0.3	-0.2	0.2	0.1	-0.0	-0.9	0.1	-0.4	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.1	0.9	0.7	1.1	0.9	0.9	-1.1	0.8	1.2	-0.2	1.5	0.4	0.9	-0.1
Friendships satisfaction	0.9	1.1	2.2	0.9	1.1	0.7	-0.2	1.2	-0.7	1.0	0.8	1.3	1.5	1.4	1.4	1.0
Qualifications: nursing, teaching	0.1	0.2	0.8	-0.4	-0.4	0.5	-0.6	-0.2	0.0	-0.1	0.2	-0.6	0.0	-0.2	0.3	-0.9
Commuting to job workplace: Walk	0.3	0.4	1.0	-0.5	-0.6	-0.6	-0.3	-0.8	0.7	-0.6	-1.0	-0.1	-0.6	0.1	-0.5	0.8
Eye problems/disorders: Cataract	0.6	0.7	2.4	1.0	0.7	1.2	0.1	0.8	-0.8	0.7	0.8	0.2	0.5	1.2	0.2	1.6
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.4	-1.2	-0.9	-1.7	-1.8	-0.9	1.0	-1.0	-1.2	-1.2	-1.1	-0.7	-0.8	-1.0
Medication for cholesterol	1.0	1.4	6.3	-1.2	-0.8	-2.5	-0.5	-1.3	1.2	-1.2	-1.9	-0.6	-0.7	0.6	-0.8	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.0	3.5	7.6	-2.0	-1.3	-2.2	-0.4	-1.8	1.6	-1.7	-1.5	-2.8	-1.4	-2.2	-1.5	-2.7
Back pain experienced in last month	1.1	1.6	5.6	1.0	0.7	0.2	0.2	0.5	-1.0	0.8	0.6	2.4	1.5	1.8	1.4	1.9
Mineral and other dietary supplements	0.2	0.3	1.9	-0.1	0.1	0.1	0.8	-0.0	0.3	-0.2	-0.3	-0.6	-0.9	-0.6	-1.4	0.1
Breast cancer (self-reported)	0.8	1.0	2.2	0.8	0.8	1.1	1.5	0.8	-1.0	1.2	1.0	-0.1	1.0	1.2	1.2	-0.6
Asthma (self-reported)	0.8	1.6	3.2	-1.5	-1.0	-0.7	-0.9	-1.2	1.5	-1.5	-1.5	-0.9	-1.8	0.1	-1.7	-0.7
Osteoporosis (self-reported)	0.3	0.4	2.4	-0.6	-0.2	-0.2	0.8	-0.5	0.4	-0.8	-0.4	-1.5	-0.3	0.2	-0.1	-0.4
Osteoarthritis (self-reported)	1.3	1.7	2.9	1.3	1.3	1.5	0.5	1.1	-1.1	1.2	1.3	1.7	0.7	1.7	1.5	1.4
Medication: Aspirin	1.3	1.7	4.0	1.4	0.6	1.5	-0.1	1.3	-1.1	1.5	1.1	2.0	1.3	1.7	1.4	0.9
Medication: Gliclazide	0.4	0.5	1.1	-0.7	-0.6	-0.7	-0.7	-1.0	0.8	-0.6	-1.0	-0.2	-1.1	0.2	-0.6	0.0
Illnesses of father: None of the above (group 1)	1.7	2.2	4.6	-1.7	-0.8	-2.1	-1.0	-1.8	1.6	-2.0	-1.9	-1.5	-1.2	-0.6	-1.2	-0.4
Smoking status: Current	1.1	1.7	4.3	-1.4	-1.9	-1.1	-0.7	-1.1	1.4	-1.3	-1.4	-0.4	-0.5	-1.7	-0.4	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.5	0.6	1.3	1.6	0.4	0.9	-0.8	1.1	1.2	-0.7	1.1	0.5	1.0	-0.4
Whole body water mass	0.1	0.5	2.5	0.7	0.2	1.6	0.2	0.3	0.1	0.7	0.7	1.5	-0.1	0.5	-0.2	0.6
Leg predicted mass (right)	0.1	0.5	1.5	-0.2	-0.6	0.7	-0.7	-0.6	1.0	-0.1	-0.2	0.4	-1.2	-0.2	-1.1	-0.2
Arm fat mass (left)	0.2	0.6	2.4	0.8	0.6	1.5	-0.0	0.6	-0.4	0.8	1.5	1.0	-0.1	0.2	0.5	-0.2
Number of self-reported non-cancer illnesses	1.6	2.9	6.1	1.9	1.6	2.5	1.1	2.0	-1.7	1.5	2.1	1.6	1.3	1.6	1.9	0.2
Average weekly champagne plus white wine intake	0.1	0.2	0.8	-0.3	-0.3	-0.1	-0.1	-0.1	0.3	-0.3	-0.6	-0.9	0.3	0.4	0.2	0.4
Miserableness	1.0	1.7	6.2	0.9	0.5	0.7	2.1	0.7	-0.6	0.5	0.6	1.0	2.5	2.0	1.2	1.2
Guilty feelings	0.6	0.9	2.8	0.9	1.0	1.7	1.0	1.3	-0.9	1.0	1.3	-0.2	0.6	0.6	0.4	-0.2
Wears glasses or contact lenses	0.5	0.6	1.4	0.9	0.9	1.2	0.8	0.6	-0.8	0.8	0.5	1.2	0.3	0.4	0.5	0.7
Ever taken oral contraceptive pill	0.8	0.9	3.1	-0.9	-0.7	-1.5	-0.4	-1.1	1.2	-1.2	-1.1	-1.7	-0.0	-0.1	-0.4	-0.4
Hearing aid user	1.4	1.6	2.8	1.4	1.2	1.7	0.7	1.7	-1.4	1.6	1.4	1.2	1.2	0.6	1.2	0.8
Mother’s age at death	3.2	4.0	6.2	-2.3	-1.4	-1.9	-1.9	-1.6	2.0	-2.1	-1.7	-2.4	-1.7	-2.5	-1.9	-2.4
Financial situation satisfaction	0.3	0.4	0.8	-0.7	-0.6	-0.1	0.3	-0.7	0.8	-0.9	-0.8	-0.3	-0.8	-0.5	-0.9	0.3
Tinnitus: Yes, now most or all of the time	1.9	2.2	6.3	-1.5	-0.8	-0.8	-1.0	-1.1	1.5	-1.5	-1.2	-2.5	-1.7	-1.4	-2.3	-1.0
Commuting to job workplace: Public transport	0.0	0.0	0.2	0.0	-0.5	0.4	-0.3	-0.1	0.1	-0.0	-0.2	0.1	-0.1	-0.2	-0.0	-0.1
Eye problems/disorders: Glaucoma	1.5	1.8	7.0	-1.2	-1.0	-1.7	-2.6	-1.5	1.3	-1.3	-1.7	-0.1	-1.2	-0.5	-1.0	-0.0
Medication: Blood pressure	1.2	2.2	8.8	1.6	0.7	3.0	1.1	1.9	-1.7	1.5	2.2	0.9	0.5	0.1	1.1	-0.3
Pain type(s) experienced in last month: Hip pain	4.2	5.3	19.8	2.2	0.7	1.5	1.1	1.7	-1.6	1.6	1.4	4.5	2.3	2.7	2.4	3.3
Supplements: Fish oil (including cod liver oil)	0.2	0.2	1.3	-0.1	-0.5	-0.2	-0.3	-0.1	-0.1	-0.2	0.1	0.7	0.6	0.4	1.1	-0.7
High cholesterol (Self-reported)	0.5	0.9	3.8	1.0	0.5	1.9	0.3	1.2	-1.0	1.1	1.2	-0.0	0.9	0.5	0.7	-0.3
Medication: Bendroflumethiazide	1.0	1.5	4.1	1.3	1.2	2.0	0.6	1.7	-1.3	1.2	1.7	0.6	0.9	0.2	1.1	0.1
Medication: Paracetamol	1.2	1.9	3.3	1.6	1.2	1.2	0.8	1.3	-1.5	1.8	1.2	1.6	1.5	1.4	0.9	1.6
Medication: Lisinopril	0.2	0.3	1.3	-0.2	0.6	0.3	-0.6	0.1	-0.2	0.1	0.6	-0.8	0.2	0.1	0.7	-1.1
Medication: Atorvastatin	0.2	0.2	1.0	-0.3	-1.0	0.3	-0.7	-0.2	0.4	-0.4	-0.3	-0.5	0.1	0.4	-0.4	-0.1
Illnesses of father: High blood pressure	1.1	1.4	4.5	-1.3	-1.7	-0.9	-1.3	-1.3	1.1	-1.0	-0.7	-0.7	-0.9	-1.0	-0.2	-2.1
Alcohol drinker status: Never	2.8	3.4	7.3	2.3	1.6	2.7	1.6	2.1	-2.3	2.3	2.1	1.5	1.3	1.0	1.1	1.3
Ever smoked	0.1	0.2	0.9	-0.4	-0.9	0.3	-0.3	-0.3	0.5	-0.4	-0.3	-0.4	0.2	0.1	0.4	-0.8
Basal metabolic rate	0.1	0.5	2.7	0.7	0.2	1.6	0.0	0.3	0.1	0.7	0.8	1.3	-0.2	0.3	-0.3	0.5
Leg fat percentage (left)	1.2	4.3	9.7	2.3	2.0	2.6	1.1	2.1	-2.1	2.0	3.1	2.4	1.8	1.2	2.2	1.1
Arm fat-free mass (left)	0.2	1.1	3.7	1.0	0.6	1.9	0.6	0.7	-0.4	1.1	1.2	1.8	0.5	0.7	0.3	0.8
Number of operations (self-reported)	4.8	7.1	10.9	2.8	2.5	3.1	1.9	2.8	-3.0	3.0	2.3	2.8	2.2	3.3	2.8	1.6
Average weekly beer plus cider intake	0.6	0.8	2.2	0.8	1.2	0.9	0.7	1.0	-0.8	0.7	1.5	-0.0	0.9	0.6	1.3	-0.1
Irritability	2.7	4.6	8.3	2.0	2.0	2.1	2.1	2.2	-1.8	2.0	2.9	2.2	2.9	1.7	2.4	1.0
Risk taking	0.9	1.3	6.6	-0.3	0.3	0.2	1.5	0.6	-0.2	0.2	1.0	-2.1	0.8	-0.8	0.9	-2.6
Ever had prostate specific antigen (PSA) test	0.3	0.4	2.2	0.2	0.1	0.5	-1.5	-0.1	-0.3	0.3	0.1	1.1	0.0	0.7	0.3	0.3
Fractured/broken bones in last 5 years	1.1	1.4	4.5	0.9	0.9	0.3	1.2	1.0	-1.0	0.9	0.8	0.7	2.1	1.5	2.0	0.6
Age started oral contraceptive pill	0.4	0.5	1.6	0.7	-0.1	1.3	0.9	1.0	-0.7	0.8	0.9	0.0	0.2	0.0	0.5	-0.7
Diastolic blood pressure, automated reading	0.6	1.8	5.1	-1.2	-1.1	-1.4	-2.2	-1.2	1.0	-1.1	-0.2	0.1	-0.7	-2.3	-0.1	-2.1
Ever depressed for a whole week	0.1	0.1	0.5	-0.2	-0.4	0.3	-0.4	-0.2	0.3	0.0	-0.2	-0.4	-0.5	0.0	-0.7	-0.4
Unable to work because of sickness or disability	2.1	2.8	6.1	1.8	1.0	1.0	0.2	1.6	-1.4	1.2	1.1	2.5	1.6	2.5	1.8	2.4
Commuting to job workplace: Cycle	2.1	2.5	4.2	-2.0	-1.6	-2.0	-1.5	-1.7	1.8	-1.7	-2.0	-1.6	-0.5	-1.1	-0.8	-1.4
Myopia	0.9	1.4	2.6	-1.2	-0.4	-0.7	-1.4	-1.4	0.8	-1.1	-1.1	-0.6	-1.5	-1.6	-1.1	-1.5
Vascular/heart problems diagnosed by doctor	0.9	2.6	5.7	-1.5	-0.6	-2.0	-1.4	-1.8	1.4	-1.3	-2.4	-1.7	-2.0	-0.6	-2.3	0.5
Cholesterol lowering medication	0.4	0.6	1.8	-0.4	-0.7	1.2	0.0	-0.2	0.5	-0.4	0.1	-0.8	-1.2	-0.9	-0.8	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.6	1.0	1.2	1.2	1.1	1.0	-1.0	0.8	1.1	0.9	0.8	1.6	1.2	0.5
Pain experienced in last month	4.5	7.5	16.9	-2.7	-2.3	-1.8	-2.1	-2.5	2.3	-2.5	-2.0	-4.0	-2.5	-3.3	-2.3	-4.1
Supplements: Calcium	1.0	1.1	3.5	-1.1	-0.9	-1.3	-1.6	-1.1	0.9	-0.8	-0.8	-1.9	-0.1	-0.7	0.0	-0.9
Basal cell carcinoma (self-reported)	0.3	0.3	1.3	-0.1	-0.4	-0.7	-0.5	-0.7	0.4	0.3	-0.3	-0.1	-1.1	-0.4	-0.8	0.8
Heart attack/myocardial infarction (self-reported)	2.1	2.8	6.6	1.6	1.0	1.7	0.8	1.7	-1.5	1.9	1.6	1.7	1.8	2.6	1.9	1.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.5	-0.1	-0.4	-0.3	-1.2	-0.7	0.6	-0.2	-0.7	-0.3	-1.2	0.2	-1.6	0.6
Heart disease (siblings)	0.2	0.3	0.7	0.3	0.1	0.3	-0.4	0.6	-0.8	0.6	0.2	-0.4	0.1	0.8	0.7	-0.5
Alcohol drinker status: Previous	0.3	0.4	1.1	-0.5	-0.5	-0.7	0.1	-1.0	0.6	-0.8	-0.8	0.1	-0.4	0.4	-0.7	0.7
Pack years of smoking	0.1	0.1	0.6	0.1	-0.2	0.1	0.7	0.3	0.2	-0.5	0.2	-0.0	0.8	0.4	0.5	-0.1
Impedance of whole body	0.7	3.6	6.4	-2.0	-2.4	-1.9	-1.1	-1.4	1.6	-2.0	-2.0	-2.5	-1.5	-2.4	-1.8	-1.5
Leg fat mass (left)	0.4	1.5	4.5	1.4	1.0	2.0	0.5	1.1	-0.9	1.2	2.1	1.7	0.6	0.4	1.0	0.2
Arm predicted mass (left)	0.2	0.8	3.1	0.9	0.4	1.8	0.3	0.5	-0.2	0.9	1.0	1.7	0.5	0.8	0.3	0.8