Best TWAS P=2.45e-21 · Best GWAS P=3.14e-26 conditioned to 1.49e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ROSMAP | Brain Pre-frontal Cortex | KIAA1432 | 0.05 | 0.00 | blup | 502 | 0.02 | 7.5e-04 | 1.8 | 5.7 | 9.9e-09 | 0.55 | 0.07 | 0.42 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | IGHEP2 | 0.08 | 0.07 | enet | 12 | 0.08 | 3.7e-10 | 9.2 | -9.5 | 2.5e-21 | -0.93 | 1.00 | 0.00 | TRUE |
| 3 | YFS | Blood | JAK2 | 0.03 | 0.03 | lasso | 4 | 0.03 | 1.4e-10 | -5.7 | 7.8 | 6.4e-15 | 0.73 | 0.99 | 0.01 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Adenocarcinoma | JAK2 | 0.07 | 0.00 | blup | 83 | 0.02 | 2.2e-03 | 9.1 | 6.5 | 6.1e-11 | 0.71 | 0.03 | 0.08 | FALSE |