[Hub]/) : Traits : Irritable Bowel Disease (IBD) :

chr10:63,253,359-65,264,300

Best TWAS P=9.71e-17 · Best GWAS P=2.31e-36 conditioned to 3.82e-22

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ADO 0.04 0.01 blup 465 0.02 1.8e-03 6.4 7.8 4.5e-15 0.52 0.02 0.87 FALSE
2 CommonMind Brain Pre-frontal Cortex RTKN2 0.07 0.01 enet 24 0.04 7.1e-06 1.4 -5.5 3.6e-08 -0.06 0.75 0.01 TRUE
3 GTEx Muscle Skeletal ADO 0.15 0.16 lasso 8 0.16 1.1e-15 7.6 8.3 9.7e-17 0.43 1.00 0.00 TRUE
4 GTEx Muscle Skeletal RP11-436D10.3 0.08 0.04 enet 13 0.06 3.2e-06 -4.0 5.6 1.6e-08 0.30 0.94 0.01 FALSE
5 GTEx Testis ADO 0.21 0.23 lasso 7 0.22 6.6e-10 7.6 -7.6 2.9e-14 -0.40 0.98 0.02 FALSE
6 The Cancer Genome Atlas Breast Invasive Carcinoma ADO 0.03 0.02 blup 53 0.03 1.8e-06 4.8 5.7 1.1e-08 0.29 0.50 0.49 FALSE
7 The Cancer Genome Atlas Brain Lower Grade Glioma ADO 0.07 0.06 blup 53 0.05 2.5e-06 6.4 6.7 2.7e-11 0.39 0.00 1.00 FALSE
8 The Cancer Genome Atlas Skin Cutaneous Melanoma EGR2 0.12 0.10 blup 56 0.10 1.4e-03 5.0 6.7 2.3e-11 0.37 0.03 0.12 FALSE