Best TWAS P=9.71e-17 · Best GWAS P=2.31e-36 conditioned to 3.82e-22
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADO | 0.04 | 0.01 | blup | 465 | 0.02 | 1.8e-03 | 6.4 | 7.8 | 4.5e-15 | 0.52 | 0.02 | 0.87 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | RTKN2 | 0.07 | 0.01 | enet | 24 | 0.04 | 7.1e-06 | 1.4 | -5.5 | 3.6e-08 | -0.06 | 0.75 | 0.01 | TRUE |
| 3 | GTEx | Muscle Skeletal | ADO | 0.15 | 0.16 | lasso | 8 | 0.16 | 1.1e-15 | 7.6 | 8.3 | 9.7e-17 | 0.43 | 1.00 | 0.00 | TRUE |
| 4 | GTEx | Muscle Skeletal | RP11-436D10.3 | 0.08 | 0.04 | enet | 13 | 0.06 | 3.2e-06 | -4.0 | 5.6 | 1.6e-08 | 0.30 | 0.94 | 0.01 | FALSE |
| 5 | GTEx | Testis | ADO | 0.21 | 0.23 | lasso | 7 | 0.22 | 6.6e-10 | 7.6 | -7.6 | 2.9e-14 | -0.40 | 0.98 | 0.02 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADO | 0.03 | 0.02 | blup | 53 | 0.03 | 1.8e-06 | 4.8 | 5.7 | 1.1e-08 | 0.29 | 0.50 | 0.49 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADO | 0.07 | 0.06 | blup | 53 | 0.05 | 2.5e-06 | 6.4 | 6.7 | 2.7e-11 | 0.39 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | EGR2 | 0.12 | 0.10 | blup | 56 | 0.10 | 1.4e-03 | 5.0 | 6.7 | 2.3e-11 | 0.37 | 0.03 | 0.12 | FALSE |