TWAS hub - RTKN2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0710	0.0220	0.00016	0.013	0.028	0.042	0.033	0.028	9.1e-03	0.00019	7.1e-06	6.8e-05	0.00022
2	METSIM	Adipose	0.0440	0.0195	0.00460	0.006	0.008	0.003	0.008	0.004	4.1e-02	0.02000	1.2e-01	2.1e-02	0.07300
3	NTR	Blood	0.0212	0.0092	0.00420	0.001	0.002	-0.001	0.003	-0.001	1.6e-01	0.04500	8.5e-01	3.9e-02	0.61000
4	ROSMAP	Brain Pre-frontal Cortex	0.0388	0.0171	0.00910	0.039	0.008	0.027	0.015	0.029	7.2e-06	0.02500	2.0e-04	4.5e-03	0.00012
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0677	0.0346	0.00290	-0.002	0.008	-0.002	NA	-0.002	5.8e-01	0.03500	7.0e-01	NA	0.69000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Hypothyroidism (self reported)	9.3	21.3	72.8	3.9	2.4	8.5	-2.2	2.8
Hypothyroidism/myxoedema (self-reported)	5.9	11.4	38.7	3.3	1.7	6.2	-1.6	1.3
High blood pressure	4.1	11.5	19.7	0.7	-4.0	-4.4	2.7	-3.7
Average weekly red wine intake	4.1	6.0	12.2	-0.5	2.7	3.5	-1.8	2.7
Medication: Levothyroxine sodium	4.0	6.7	25.9	1.9	0.3	5.1	-1.9	0.7
Medication: Ibuprofen	3.9	4.7	8.1	-1.2	-2.8	-2.8	0.8	-2.3
Irritable Bowel Disease (IBD)	3.8	9.0	30.3	-5.5	-2.7	-2.2	-1.4	0.5
Hypertension (Self-reported)	3.8	10.7	18.6	0.5	-3.9	-4.3	2.6	-3.6
Medication: Ibuprofen (e.g. Nurofen)	3.4	4.3	7.5	-0.5	-2.7	-2.7	1.6	-1.9
Average weekly beer plus cider intake	3.4	4.9	12.0	0.9	0.1	-3.5	3.4	-0.4
Vascular/heart problems diagnosed by doctor	3.4	9.3	16.0	-0.3	3.5	4.0	-1.9	3.8
Tinnitus: Yes, but not now, but have in the past	3.3	3.5	8.0	0.4	-2.8	-2.3	1.4	-1.4
Lupus	3.2	4.9	16.6	2.7	-0.1	4.1	-0.2	0.7
Ulcerative Colitis (UC)	3.1	5.8	22.2	-4.7	-0.9	-1.4	-1.4	1.4
Qualifications: O levels/GCSEs or equivalent	3.1	5.0	7.9	-1.6	1.7	2.6	-2.2	2.8
Reaction Time	2.8	5.3	13.7	-3.7	-0.1	0.3	-3.6	0.1
Medication: Blood pressure	2.8	5.4	12.8	-0.9	-3.6	-2.7	0.9	-2.2
Other serious medical condition/disability diagnosed by doctor	2.7	3.5	9.6	-0.3	1.5	3.1	-1.9	1.3
Impedance of arm (right)	2.7	12.6	19.2	-0.6	4.1	4.3	-3.0	4.4
Health satisfaction	2.6	3.3	9.8	1.7	-3.1	-0.8	1.8	-0.6
Medication for pain relief, constipation, heartburn	2.6	4.4	12.8	0.2	3.6	1.6	0.2	2.6
Crohns Disease (2017)	2.5	5.6	15.7	-4.0	-2.9	-1.8	-0.9	-0.3
Headache pain in last month	2.5	4.2	7.9	0.1	-2.8	-2.0	1.5	-2.6
Cardiovascular Disease	2.4	7.9	15.1	-1.1	-3.9	-3.2	1.4	-3.3
Hearing difficulty/problems with background noise	2.2	3.5	9.1	1.2	-1.7	-1.3	1.6	-3.0
Medication: Lansoprazole	2.2	2.5	8.6	-2.9	0.1	0.2	-1.3	1.5
Angina (self-reported)	2.2	2.9	6.1	1.9	2.5	0.7	0.1	2.1
Verbal and Numeric Reasoning (VNR)	2.1	5.0	11.8	-0.0	3.4	1.3	-2.0	2.8
Rheumatoid Arthritis	2.1	2.9	7.4	2.7	-1.7	2.0	-0.2	0.4
Chest pain or discomfort	2.1	3.0	6.0	-0.8	1.5	1.7	-2.5	1.7
Breast Cancer	2.0	4.7	12.5	2.6	2.1	3.5	-0.0	0.3
Triglycerides	2.0	3.2	7.8	0.4	-2.8	-0.6	0.2	-2.7
Type 2 Diabetes (T2D) (2012)	2.0	2.3	6.8	-1.3	-2.6	-1.7	0.4	0.2
Waist Hip Ratio (WHR)	2.0	8.8	13.6	1.9	-2.9	-3.7	3.4	-2.7
Diabetes (mother)	2.0	2.6	8.4	-0.3	-2.1	-0.2	-0.0	-2.9
Prospective memory result	2.0	2.5	5.5	-1.2	1.6	1.3	-1.0	2.3
Impedance of arm (left)	2.0	9.2	16.2	-0.5	3.4	3.5	-2.4	4.0
Medication for cholesterol	2.0	3.0	5.4	0.9	2.3	2.2	-0.5	2.0
High cholesterol (Self-reported)	2.0	3.5	5.7	-1.0	-2.3	-2.4	0.4	-2.3
Angina	1.9	2.5	6.0	1.6	2.4	0.7	0.0	1.9
Ulcerative Colitis	1.8	2.6	8.5	-2.9	0.0	-0.3	-0.7	1.9
Smoking Status	1.8	4.4	8.2	0.7	-2.4	-2.8	0.3	-2.9
Average weekly fortified wine intake	1.8	2.1	4.9	1.8	0.4	1.0	0.9	2.2
Comparative body size at age 10	1.8	4.9	10.6	-2.2	-3.3	-1.7	0.2	-2.4
Medication: Seretide 50 evohaler	1.8	2.1	8.7	0.2	2.9	0.9	-0.7	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.2	4.6	-0.8	-2.1	-0.6	-0.9	-2.1
Type 2 Diabetes (T2D) (2018)	1.7	3.3	7.7	0.6	-1.9	-2.1	2.8	0.6
Severe depression (siblings)	1.7	1.9	3.0	-1.7	-1.7	-1.6	-0.3	-1.1
Average weekly champagne plus white wine intake	1.7	2.3	7.4	2.7	0.1	-0.1	2.0	-0.3
Impedance of whole body	1.7	8.8	15.4	-0.7	3.3	3.9	-2.5	3.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.2	13.0	-2.3	0.5	2.8	-3.6	-0.0
Gout (self-reported)	1.6	2.2	5.1	-1.6	-0.3	-2.3	-0.4	-1.8
Medication: Amlodipine	1.6	2.3	7.4	0.2	-0.8	-2.7	1.4	-1.2
Illnesses of father: High blood pressure	1.6	2.0	4.5	0.7	-1.5	-2.1	1.2	-1.2
Schizophrenia (2018)	1.5	3.2	8.1	1.5	-2.3	-0.3	2.8	-0.7
LDL Cholesterol	1.5	2.4	7.6	1.4	-2.8	-0.4	1.5	-0.2
Alcohol usually taken with meals	1.5	2.4	4.4	2.1	1.0	1.9	0.6	1.6
Fluid intelligence score	1.5	3.0	4.9	0.7	2.2	2.0	-1.3	2.0
Blood clot in the leg (DVT)	1.5	1.9	3.5	1.8	-0.5	-0.2	1.9	1.5
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	5.2	0.1	2.3	1.9	-0.7	1.7
Number of children fathered	1.5	1.7	4.9	1.6	-2.2	0.1	0.7	-0.9
Eye problems/disorders: None of the above	1.5	1.8	3.8	1.5	0.9	-1.1	1.9	0.9
Migraine (self-reported)	1.5	1.8	3.5	-0.6	-1.9	-1.4	0.6	-1.7
Tinnitus: Yes, now most or all of the time	1.5	1.8	4.0	-0.1	2.0	1.4	-1.3	1.1
Heart attack/myocardial infarction (self-reported)	1.5	1.9	3.2	-0.6	1.6	1.7	-1.8	0.7
Average weekly spirits intake	1.4	1.8	4.7	-1.3	-0.8	1.2	-2.2	0.5
Hearing difficulty/problems: Yes	1.4	2.1	7.0	-0.1	-2.7	-0.7	0.7	-1.6
Impedance of leg (right)	1.4	7.0	11.3	-0.8	3.2	3.4	-2.1	2.8
Current tobacco smoking	1.4	2.2	3.3	-1.3	-1.2	-1.8	-1.2	-1.8
Age when periods started (menarche)	1.4	3.4	11.0	-0.5	1.1	1.2	-1.7	3.3
Financial difficulties in last 2 years	1.4	1.9	3.2	-1.8	1.5	-1.5	-1.3	-0.3
Noisy workplace	1.4	1.7	3.7	-1.1	-1.6	-1.9	0.0	-0.9
Mean time to correctly identify matches	1.4	2.6	6.6	-2.1	-0.7	-0.4	-2.6	-1.1
Had major operations	1.4	1.6	2.9	0.6	1.6	1.4	-1.7	0.5
Irritability	1.4	2.4	4.2	-1.8	-1.9	0.4	-2.1	-1.1
Diastolic blood pressure, automated reading	1.4	4.4	8.6	0.7	-2.2	-2.9	2.4	-1.7
Intelligence (Savage-Jansen 2018)	1.3	4.1	7.9	-0.6	2.8	1.8	-2.5	1.7
Neuroticism (Nagel 2018)	1.3	3.0	8.0	-1.1	-1.3	-0.8	-1.8	-2.8
Medication: Atenolol	1.3	1.7	3.1	-1.7	-0.9	-1.8	-0.9	-0.9
Impedance of leg (left)	1.3	6.3	13.8	-0.9	2.8	3.7	-2.2	2.1
Past tobacco smoking	1.3	2.4	4.2	-1.0	1.6	1.8	-0.9	2.1
Mouth/teeth dental problems	1.3	2.0	4.9	0.9	1.3	0.8	1.4	2.2
Diabetes (self-reported)	1.3	2.0	5.7	-0.1	-2.4	-1.8	0.8	-0.6
Forced expiratory volume in 1-second (FEV1)	1.3	4.3	9.4	-1.6	0.9	3.1	-2.9	0.7
Breastfed as a baby	1.3	1.6	6.9	-0.3	2.6	0.1	-0.9	0.7
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	6.6	-0.2	-2.6	-0.7	0.0	-1.3
Medication: Paracetamol	1.3	2.1	4.9	1.2	-2.2	-0.3	0.4	-2.0
Chronic bronchitis/emphysema (mother)	1.3	1.5	3.6	1.9	-0.7	-0.5	0.3	-1.7
High blood pressure (siblings)	1.3	1.9	4.0	0.3	-1.7	-2.0	-0.3	-1.5
Smoking status: Current	1.3	2.1	3.8	-0.8	-1.3	-2.0	-0.7	-1.9
Bipolar Disorder (2011)	1.2	1.1	1.6	-0.9	-0.7	1.2	-1.3	1.2
Number of treatments/medications taken	1.2	2.1	6.7	-0.7	-2.6	-0.7	-0.5	-1.6
Maternal smoking around birth	1.2	1.7	3.9	2.0	2.0	0.6	0.5	-0.2
Medication: Simvastatin	1.2	1.8	3.8	-1.4	-1.5	-2.0	0.4	-0.8
Hair/balding pattern: Pattern 3	1.2	1.8	5.5	0.8	-1.4	-2.4	0.7	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	5.6	-1.7	0.1	-0.1	-2.4	-0.7
Loud music exposure frequency	1.2	1.4	4.1	-1.4	-0.5	-2.0	0.2	-0.5
Forced vital capacity (FVC), Best measure	1.2	4.6	10.7	-2.2	0.5	2.7	-3.3	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	5.5	0.0	-0.7	-0.9	-0.9	-2.3
Medication: Allopurinol	1.2	1.6	3.5	-0.6	-1.2	-1.9	0.2	-1.6
Long-standing illness, disability or infirmity	1.2	1.9	6.9	0.2	-0.0	2.6	-1.5	-0.5
Diabetes diagnosed by doctor	1.2	2.0	4.3	-0.5	-2.1	-2.0	0.9	-0.6
Qualifications: nursing, teaching	1.2	1.9	4.3	1.3	0.7	2.1	-0.2	1.6
Back pain experienced in last month	1.2	1.8	6.8	-0.5	-2.6	-0.7	-0.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	6.2	-0.7	-0.5	2.5	-2.4	0.4
Commuting to job workplace: Public transport	1.2	1.4	4.5	0.5	0.0	-2.1	1.3	-0.8
Medication: Bendroflumethiazide	1.2	1.8	3.1	0.2	-1.8	-1.5	1.3	-1.5
Pain experienced in last month	1.2	1.9	7.2	1.1	2.7	0.5	0.1	1.0
Fasting Glucose	1.1	1.3	3.6	-0.2	-0.5	-1.6	0.6	-1.9
Neuroticism	1.1	2.6	4.9	-1.4	-1.5	0.0	-1.9	-2.2
Waist circumference	1.1	4.1	7.0	1.7	-2.6	-1.9	1.9	-1.8
Heart attack	1.1	1.4	2.9	-0.8	1.3	1.4	-1.7	0.2
Father’s age at death	1.1	1.5	2.9	0.5	-0.3	-1.6	1.3	-1.7
Mouth/teeth dental problems: Dentures	1.1	1.9	6.5	-0.4	-0.0	-0.8	-1.5	-2.5
Peak expiratory flow (PEF)	1.1	2.5	7.6	-0.5	1.4	2.8	-1.5	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	3.8	1.5	-0.3	0.1	1.9	0.4
Mood swings	1.1	2.0	3.6	-1.3	-1.7	-0.7	-1.2	-1.9
Illnesses of father: None of the above (group 1)	1.1	1.3	3.5	0.7	0.9	1.2	-0.4	1.9
Risk taking	1.1	1.6	7.4	0.1	0.2	2.7	-0.7	-0.5
Depressed Affect (Nagel 2018)	1.0	2.2	5.6	-1.3	-0.8	-0.5	-1.7	-2.4
Medication: Co-codamol	1.0	1.2	1.8	0.9	-1.3	-0.7	1.0	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	6.3	1.0	-2.5	-0.4	1.9	0.0
Multivitamins +/- minerals	1.0	1.2	3.5	-1.0	1.9	-0.9	-0.7	0.5
Qualifications: None of the above	1.0	2.1	5.5	-0.3	-2.4	-1.6	0.8	-1.2
Medication: Ramipril	1.0	1.3	3.9	-1.0	-1.2	-2.0	0.5	0.2
Illnesses of siblings	1.0	1.4	3.8	-0.4	1.8	0.2	0.4	1.9
Worry too long after embarrassment	1.0	1.7	3.3	-1.6	-1.1	-0.5	-1.8	-1.2
Wheeze or whistling in the chest in last year	1.0	1.8	3.9	2.0	-1.3	-0.9	1.6	0.2
Medication: Aspirin	1.0	1.3	4.8	0.4	-2.2	-0.3	-0.3	-1.3
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.2	-1.4	-0.9	-1.3	-0.3	-1.8
Eye problems/disorders: Glaucoma	1.0	1.1	2.1	-0.9	-0.9	0.2	-1.5	-1.4
Medication: Paracetamol	1.0	1.5	4.0	0.2	-2.0	-0.3	-0.3	-1.8
Ever smoked	1.0	1.7	5.0	-0.5	-1.0	-1.4	-0.5	-2.2
Age started oral contraceptive pill	1.0	1.3	4.2	-0.7	-0.7	-2.0	1.2	0.1
Ever depressed for a whole week	1.0	1.2	2.6	-0.6	-0.9	-1.3	-0.8	-1.6
Myopia	1.0	1.5	6.8	0.6	0.5	0.2	0.2	-2.6
Primary Biliary Cirrhosis	0.9	1.3	6.2	-0.1	-2.5	-0.3	-0.3	-0.3
Lung FVC	0.9	4.6	11.0	-2.5	-0.7	2.2	-3.3	-0.6
Medication: Metformin	0.9	1.2	4.1	-0.5	-0.7	-2.0	0.7	-0.9
Stomach or abdominal pain in last month	0.9	1.1	4.5	0.5	-2.1	0.6	0.1	-0.7
Forced vital capacity (FVC)	0.9	3.4	6.7	-1.7	0.9	2.6	-2.6	0.6
Neuroticism score	0.9	1.9	4.4	-0.8	-1.6	0.4	-2.1	-1.3
Alcohol intake versus 10 years previously	0.9	1.3	2.3	0.6	-0.6	-1.2	1.5	-1.5
Length of working week for main job	0.9	1.0	3.0	0.2	0.3	-0.9	1.1	1.7
Tense / ‘highly strung’	0.9	1.5	3.8	0.1	-1.9	-0.1	-0.8	-1.7
Pulse wave peak to peak time	0.9	1.1	1.9	0.7	1.3	-0.6	0.9	1.4
Osteoarthritis (self-reported)	0.9	1.2	2.6	1.5	-0.7	0.0	1.6	0.8
Miserableness	0.9	1.5	3.5	-1.9	-0.3	-0.7	-1.7	-0.7
Ever taken oral contraceptive pill	0.9	1.0	2.4	-1.3	0.1	-0.4	-1.5	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.4	1.4	-0.3	0.1	1.3	1.5
Crohns Disease (2012)	0.8	1.3	3.3	-1.8	-1.7	0.3	-0.5	0.1
Chronotype (morning person)	0.8	1.8	4.0	1.9	0.8	2.0	-0.5	0.7
Medication for hormone replacement therapy	0.8	0.9	2.2	-0.1	-0.9	-1.1	-0.3	-1.5
Pack years adult smoking proportion	0.8	1.2	2.1	-1.4	0.2	0.8	-1.2	1.4
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.0	-0.1	1.4	0.8	-0.9	1.3
Chronic bronchitis/emphysema (father)	0.8	1.0	3.3	0.1	-0.8	-1.0	-0.0	-1.8
Body mass index (BMI)	0.8	3.3	8.7	0.4	-3.0	-1.4	1.2	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	6.9	0.3	-2.6	-0.4	1.2	0.2
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	3.6	0.1	0.2	-0.7	-0.7	-1.9
Pulse rate	0.8	1.4	4.8	-1.0	-1.0	-2.2	0.1	-0.3
Qualifications: A levels/AS levels or equivalent	0.8	1.8	5.0	0.3	0.5	0.9	1.7	2.2
Pulse wave reflection index	0.8	1.0	3.0	0.1	-1.7	0.1	-0.0	-1.4
Arm fat-free mass (right)	0.8	3.9	6.8	2.2	-1.4	-2.3	2.6	-0.9
Shortness of breath walking on level ground	0.8	1.0	1.5	-0.6	-1.2	-1.0	-1.1	-1.0
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.6	0.3	0.4	1.1	-0.2	1.9
Heart disease (mother)	0.8	0.9	2.0	1.4	1.1	0.1	0.4	1.1
Arm predicted mass (right)	0.8	4.0	6.4	2.3	-1.5	-2.1	2.5	-1.3
Pulse rate, automated reading	0.8	2.7	7.7	-2.0	-1.3	-2.8	0.0	-0.3
Number of full sisters	0.8	1.0	3.2	-0.9	-0.7	0.2	-1.8	0.4
Age at last live birth	0.8	1.1	4.2	0.9	-0.6	0.0	2.1	-0.4
Knee pain experienced in last month	0.8	1.2	2.4	-1.2	0.5	1.5	-1.5	-0.0
Commuting to job workplace: Cycle	0.8	0.9	2.7	0.6	-1.2	-0.5	1.6	-0.2
Pack years of smoking	0.8	1.2	1.8	-1.3	0.1	0.9	-1.4	1.2
Body Mass Index (BMI) (2010)	0.7	0.9	3.0	0.2	-1.7	-0.4	0.3	-1.2
HbA1C	0.7	0.8	1.8	1.0	-0.9	0.4	0.6	-1.4
Hand grip strength (left)	0.7	1.8	4.7	-1.2	2.2	1.0	-0.8	1.1
Systolic blood pressure, automated reading	0.7	2.0	4.9	0.8	1.0	-2.2	1.5	1.0
Hand grip strength (right)	0.7	1.9	4.7	-1.0	2.2	0.8	-0.9	1.6
Taking other prescription medications	0.7	1.1	2.4	1.6	-1.4	0.7	0.8	-0.0
Qualifications: CSEs or equivalent	0.7	1.0	2.3	-0.1	1.3	0.6	-0.7	1.5
Pain all over the body in last month	0.7	0.8	1.7	1.3	-1.1	0.6	0.7	-0.6
Medication: Cholesterol lowering	0.7	1.1	2.8	-0.8	-1.3	-1.7	0.2	-0.7
Pulse wave Arterial Stiffness index	0.7	0.8	1.3	-0.5	-1.1	0.8	-0.9	-1.1
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.2	0.4	0.2	1.3	0.6	1.5
Age at first live birth	0.7	1.3	4.2	1.3	0.1	-0.2	2.1	0.7
Medication: Blood pressure	0.7	1.3	3.0	0.6	-1.1	-1.7	1.1	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.6	0.8	-0.5	-1.1	1.3	-0.7
Guilty feelings	0.7	1.1	2.6	0.7	-1.4	0.2	-0.6	-1.6
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.8	-1.7	-1.1	0.1	-0.6	-0.2
Alcohol drinker status: Previous	0.7	0.8	2.0	1.4	0.3	1.2	0.6	-0.6
Bipolar Disorder (2018)	0.6	1.0	2.0	-0.7	0.3	1.3	-1.4	0.8
Worry (Nagel 2018)	0.6	1.3	3.2	0.0	-1.3	-1.2	-0.2	-1.8
Major Depression (MDD)	0.6	0.7	2.1	-0.0	-1.4	-1.0	0.6	-0.6
HDL Cholesterol	0.6	1.0	2.4	-0.4	1.5	-0.7	0.6	1.3
Blood White Count	0.6	4.2	8.8	-0.7	-1.8	-3.0	0.4	-2.8
Height	0.6	11.5	22.6	4.1	3.5	-0.6	2.2	4.8
Systolic Blood Pressure	0.6	3.1	5.8	0.6	2.4	-2.0	1.1	2.0
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.0	0.0	-1.1	-0.5	-0.4	-1.4
Supplements: Zinc	0.6	0.7	2.0	0.2	1.4	0.9	-0.1	0.7
Diabetes (father)	0.6	0.7	1.9	-1.4	0.4	0.3	-1.2	0.3
Fed-up feelings	0.6	1.0	3.5	-0.8	-0.2	0.9	-1.9	-0.4
Leg predicted mass (left)	0.6	3.0	5.5	2.3	-0.9	-1.9	2.1	-0.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	2.3	0.5	1.5	-0.2	0.2	1.0
Time employed in main current job	0.6	0.7	1.6	0.4	-0.5	0.5	1.1	1.3
Birth weight	0.6	1.3	4.1	-0.3	1.4	0.2	0.4	2.0
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.6	0.8	-0.6	1.6	0.2	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.8	-0.2	-0.9	-1.4	0.8	0.1
Smoking status: Previous	0.6	0.9	1.2	1.1	-0.9	-1.1	0.9	-0.7
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.4	0.0	-1.2	-1.0	0.8	-0.5
Financial situation satisfaction	0.6	0.7	1.7	-1.3	0.1	-1.1	-0.4	-0.8
Unable to work because of sickness or disability	0.6	0.7	1.9	0.4	-0.9	-0.9	0.1	-1.4
Cholesterol lowering medication	0.6	0.9	3.0	-0.1	-1.7	-0.9	0.5	-0.7
Leg fat mass (left)	0.6	2.3	4.8	1.3	-2.2	-0.8	1.6	-1.5
Arm predicted mass (left)	0.6	2.8	4.3	1.9	-1.4	-1.8	2.1	-0.9
Alzheimer’s Disease (in mother)	0.5	0.6	1.4	-0.8	1.2	0.2	-0.7	0.6
Alzheimer’s Disease (in father)	0.5	0.5	1.3	-0.4	-1.1	-0.7	-0.8	-0.4
Neuroticism (2016)	0.5	0.7	1.4	-1.2	-0.5	-0.9	-0.4	-0.9
Blood Eosinophil Count	0.5	4.0	16.2	4.0	1.2	1.4	0.4	-0.3
Heel T-Score	0.5	4.3	7.5	1.7	-2.7	-0.7	2.4	2.2
Leg fat-free mass (left)	0.5	2.8	5.8	2.4	-0.8	-1.8	2.1	-0.2
Relative age voice broke	0.5	0.8	1.0	-1.0	1.0	0.6	-0.9	1.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.1	0.3	-0.2	-0.6	-0.5	-1.5
Sitting height	0.5	3.7	9.0	3.0	-0.6	-0.2	2.8	1.2
Hair/balding pattern: Pattern 2	0.5	0.6	2.2	-0.9	-0.2	0.4	-0.0	1.5
Trunk fat-free mass	0.5	3.1	6.6	2.6	-0.5	-1.7	2.3	-0.4
Worrier / anxious feelings	0.5	1.0	1.9	-1.4	-0.3	-0.5	-1.2	-1.2
Number of live births	0.5	0.7	1.4	-0.8	-0.8	1.2	-0.6	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.2	0.4	-0.4	-1.1	0.5	-1.1
Lung cancer (father)	0.5	0.6	1.0	0.4	-1.0	0.7	0.7	-1.0
Illnesses of mother	0.5	0.6	1.2	-0.1	-0.4	-0.9	1.1	1.0
Trunk predicted mass	0.5	2.9	6.5	2.5	-0.4	-1.7	2.2	-0.3
Standing height	0.5	4.5	9.0	3.0	2.3	0.4	1.1	2.6
Hair/balding pattern: Pattern 4	0.5	1.2	2.3	1.2	0.3	1.5	0.9	1.1
Leg fat mass (right)	0.5	2.0	3.9	1.2	-2.0	-0.9	1.5	-1.2
Leg pain on walking	0.5	0.6	1.8	0.1	0.4	1.4	0.1	1.0
Supplements: Vitamin C	0.5	0.6	1.4	0.8	-1.2	0.7	0.1	0.5
Whole body fat-free mass	0.5	3.0	5.7	2.4	-0.8	-1.9	2.2	-0.5
Leg fat-free mass (right)	0.5	2.6	5.1	2.3	-0.9	-1.7	1.9	-0.5
Commuting to job workplace: Walk	0.5	0.6	1.3	0.6	-0.4	-0.6	0.7	-1.2
Medication: Aspirin	0.5	0.7	2.6	0.5	-1.6	-0.3	0.0	-0.6
Medication: Gliclazide	0.5	0.6	1.3	-1.1	0.2	0.4	-1.1	-0.5
Whole body water mass	0.5	2.8	5.5	2.3	-0.8	-1.8	2.2	-0.5
Leg predicted mass (right)	0.5	2.5	4.9	2.2	-0.9	-1.7	1.9	-0.5
Number of self-reported non-cancer illnesses	0.5	0.8	1.8	1.3	-1.2	0.3	0.8	0.1
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.4	-0.5	-0.2	1.2	-0.6	1.1
Basal metabolic rate	0.5	2.8	5.4	2.3	-0.9	-1.7	2.2	-0.4
Leg fat percentage (left)	0.5	1.6	4.5	0.4	-2.1	-0.2	0.9	-1.6
Arm fat-free mass (left)	0.5	2.4	3.7	1.9	-1.1	-1.6	1.9	-0.9
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.7	1.3	0.0	0.1	1.0	-0.6
Basal cell carcinoma (self-reported)	0.5	0.6	2.2	-0.1	0.2	-0.1	0.9	1.5
Heart disease (siblings)	0.5	0.7	1.7	-0.2	-0.1	1.3	-1.2	-0.2
Bipolar Disorder or Schizophrenia	0.4	1.0	2.5	0.7	-1.6	0.6	1.3	-0.1
Schizophrenia vs Biploar Disorder	0.4	0.6	1.5	0.1	-1.1	0.2	-0.0	-1.2
Alzheimer’s Disease (including proxy)	0.4	0.5	1.6	-1.3	0.1	-0.4	-0.7	0.5
Ovarian Cancer	0.4	0.5	1.2	0.7	0.0	-1.1	1.0	-0.3
Relative age of first facial hair	0.4	0.8	1.9	-0.7	0.4	0.6	-1.0	1.4
Supplements: Glucosamine	0.4	0.6	1.4	-0.4	0.9	0.6	0.1	1.2
High blood pressure (mother)	0.4	0.6	1.5	-1.2	0.3	0.3	-1.0	-0.4
Weight	0.4	2.1	3.1	1.8	-1.6	-1.1	1.7	-0.6
Falls in the last year	0.4	0.6	1.5	-0.2	-1.1	-0.0	-0.1	-1.2
Asthma	0.4	0.8	2.1	1.4	0.3	1.3	-0.3	0.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.0	-0.7	-0.5	-1.0	0.0	-0.9
Number of full brothers	0.4	0.5	1.1	-0.5	-0.5	-1.0	-0.7	-0.7
Qualifications: College or University degree	0.4	1.4	4.2	0.9	0.6	0.1	2.0	1.2
Neck or shoulder pain in last month	0.4	0.6	2.1	-0.9	-0.2	0.1	-1.4	-0.2
Alcohol intake frequency.	0.4	0.8	1.7	0.3	-1.3	-0.0	0.8	-1.3
Overall health rating	0.4	0.9	1.9	1.4	-1.3	0.1	0.9	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.2	0.3	0.0	-0.9	0.5	-1.1
Loneliness, isolation	0.4	0.6	1.1	0.6	-1.1	-0.5	-0.4	-0.9
Ever had bowel cancer screening	0.4	0.5	1.2	0.2	-1.1	-0.7	0.6	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.0	0.7	-1.0	0.2	0.7	0.4
Mineral and other dietary supplements	0.4	0.6	1.7	1.3	1.0	-0.1	-0.2	0.4
Arm fat mass (left)	0.4	1.7	4.9	1.0	-2.2	-0.7	1.2	-0.8
Wears glasses or contact lenses	0.4	0.4	1.4	0.6	-0.4	0.4	-0.1	-1.2
Mother’s age at death	0.4	0.4	1.0	-0.8	1.0	-0.3	0.2	0.6
Schizophrenia (2014)	0.3	0.7	1.8	0.2	-0.8	1.3	0.9	0.7
Blood Red Count	0.3	2.6	7.0	0.8	-0.1	-2.3	2.6	-0.0
BMI	0.3	1.8	5.6	0.1	-2.4	-0.5	1.0	-1.4
Lung FEV1/FVC ratio	0.3	1.3	3.7	1.1	0.7	1.9	-0.2	1.1
Ever had hysterectomy (womb removed)	0.3	0.4	1.1	0.5	-0.4	-1.1	0.2	-0.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.9	0.0	-0.8	0.4	-0.4	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.5	-0.3	0.5	-1.2	-0.6	0.2
Serious illness, injury or assault to yourself	0.3	0.4	1.0	-0.3	-0.1	-0.8	-0.3	-1.0
Trunk fat mass	0.3	1.2	2.2	1.5	-1.5	0.0	1.3	-0.1
Nervous feelings	0.3	0.6	1.4	0.2	-0.9	-0.6	-0.8	-1.2
Allergy	0.3	0.6	1.7	-1.3	-0.1	0.1	-1.0	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.9	-0.1	0.8	0.8	-0.4	1.0
Depression (self-reported)	0.3	0.4	1.7	-0.1	-0.0	-1.3	0.6	0.3
Leg fat percentage (right)	0.3	1.1	3.2	0.4	-1.8	-0.2	0.7	-1.2
Exposure to tobacco smoke outside home	0.3	0.4	0.9	-0.3	0.9	0.1	-1.0	0.4
Whole body fat mass	0.3	1.1	2.7	1.1	-1.7	-0.1	1.0	-0.7
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.5	0.1	-0.2	1.2	0.3	0.2
Illnesses of siblings: Diabetes	0.3	0.4	1.1	0.6	0.1	1.0	-0.4	-0.5
Friendships satisfaction	0.3	0.4	0.9	0.6	0.1	0.0	-1.0	0.8
Asthma (self-reported)	0.3	0.6	1.4	1.2	0.3	1.0	-0.5	0.5
Hearing aid user	0.3	0.4	1.1	-0.8	-1.1	-0.3	0.2	0.0
Alcohol drinker status: Never	0.3	0.4	1.8	0.3	-1.3	-0.1	-0.0	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.1	-0.4	0.1	1.0	-0.1	0.7
Supplements: Calcium	0.3	0.3	1.2	-0.2	0.2	0.6	-0.1	1.1
Prostate Cancer	0.2	0.2	0.6	-0.3	0.3	-0.1	-0.8	-0.6
Coronary Artery Disease (CAD)	0.2	0.2	0.8	0.4	0.2	-0.1	0.9	0.5
Mean Putamen Volume	0.2	0.2	0.6	-0.4	-0.5	0.4	0.2	-0.8
Blood Platelet Count	0.2	1.8	5.1	-1.3	-1.4	2.2	0.3	0.6
Tanning	0.2	1.9	5.1	-0.8	2.3	-0.4	-0.9	-1.6
Sensitivity / hurt feelings	0.2	0.4	0.6	0.7	0.1	0.7	-0.8	-0.4
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.3	-0.5	-0.5	-0.0	-0.5	0.6
Trunk fat percentage	0.2	0.7	1.7	1.0	-1.3	0.8	0.6	0.2
Townsend deprivation index at recruitment	0.2	0.3	0.9	-0.6	0.7	-0.9	-0.2	-0.2
Number of incorrect matches in round	0.2	0.3	1.0	-0.0	-1.0	-0.2	0.5	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.6	-0.2	-1.2	0.1	-0.3	-0.1
Had menopause	0.2	0.3	0.8	0.2	0.3	0.6	-0.3	-0.9
Had other major operations	0.2	0.3	0.7	-0.5	-0.1	-0.6	-0.2	-0.8
Hip circumference	0.2	0.7	1.5	1.2	-1.2	-0.1	0.8	-0.1
Arm fat mass (right)	0.2	1.0	3.2	0.7	-1.8	-0.4	1.0	-0.4
Exposure to tobacco smoke at home	0.2	0.2	0.7	-0.5	-0.8	-0.1	-0.2	-0.0
Birth weight of first child	0.2	0.3	0.8	-0.1	0.4	0.4	-0.9	-0.5
Body fat percentage	0.2	0.7	2.3	0.6	-1.5	0.5	0.5	-0.6
Emphysema/chronic bronchitis	0.2	0.3	0.9	0.1	0.9	0.6	0.0	0.4
Comparative height size at age 10	0.2	0.9	2.3	0.1	1.5	-1.1	0.3	0.9
Family relationship satisfaction	0.2	0.2	0.7	-0.8	-0.4	-0.3	-0.5	-0.1
Illnesses of father: Heart disease	0.2	0.3	0.8	0.7	0.2	0.9	0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.0	0.8	0.3	-1.0	-0.0	0.5
Arm fat percentage (left)	0.2	1.0	3.6	0.3	-1.9	-0.2	0.8	-0.7
Eye problems/disorders: Cataract	0.2	0.2	0.6	-0.5	0.1	-0.8	-0.0	-0.6
Breast cancer (self-reported)	0.2	0.2	0.4	0.4	0.6	0.2	-0.1	0.7
Osteoporosis (self-reported)	0.2	0.3	0.6	-0.5	0.5	0.8	-0.7	0.1
Medication: Atorvastatin	0.2	0.3	0.9	1.0	-0.2	-0.0	-0.2	-0.6
Number of operations (self-reported)	0.2	0.2	0.5	0.4	-0.1	0.7	-0.7	-0.3
Fractured/broken bones in last 5 years	0.2	0.2	0.3	0.6	0.2	0.6	-0.4	-0.4
Depression (Nagel 2018)	0.1	0.2	0.9	0.2	-0.1	-1.0	-0.1	0.3
Age at First Birth	0.1	0.2	1.0	0.2	1.0	0.0	0.1	0.1
Allergy or Eczema	0.1	0.2	0.6	-0.7	-0.3	-0.4	0.2	-0.0
Respiratory disease	0.1	0.3	0.5	0.7	-0.5	0.6	-0.5	-0.5
Hair Pigment	0.1	3.6	9.4	-0.9	1.9	1.1	-3.1	1.8
Vitamin and mineral supplements	0.1	0.1	0.2	0.4	-0.0	0.3	0.1	-0.3
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.4	-0.6	-0.3	-0.3	-0.3	-0.3
Arm fat percentage (right)	0.1	0.5	2.3	0.2	-1.5	0.3	0.3	-0.5
Happiness	0.1	0.1	0.4	-0.3	0.1	-0.1	-0.1	0.6
Glaucoma (self-reported)	0.1	0.1	0.2	-0.2	-0.4	-0.2	-0.2	-0.3
Suffer from ‘nerves’	0.1	0.2	0.5	-0.6	0.5	-0.4	-0.7	-0.0
Medication: Lisinopril	0.1	0.1	0.4	-0.1	-0.3	0.1	0.2	-0.6
Medication: Omeprazole	0.0	0.0	0.1	-0.0	0.2	0.3	0.2	0.2

Hub : Genes

RTKN2

Models

Trait associations