Best TWAS P=2.46e-49 · Best GWAS P=4.82e-111 conditioned to 7.16e-68
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NTR | Blood | IL12RB2 | 0.04 | 0.02 | bslmm | 539 | 0.02 | 1.9e-08 | -5.0 | -6.1 | 1.2e-09 | 0.18 | 1.00 | 0.00 | TRUE |
| 2 | NTR | Blood | MIER1 | 0.03 | 0.01 | bslmm | 573 | 0.01 | 2.7e-05 | -1.5 | -7.1 | 1.0e-12 | 0.25 | 0.88 | 0.01 | TRUE |
| 3 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | IL23R | 0.06 | 0.03 | blup | 107 | 0.03 | 7.0e-03 | 10.3 | 14.8 | 2.5e-49 | -0.13 | 0.15 | 0.10 | TRUE |
| 4 | The Cancer Genome Atlas | Rectum Adenocarcinoma | IL23R | 0.17 | 0.03 | blup | 108 | 0.15 | 2.3e-04 | -6.2 | 14.0 | 8.5e-45 | -0.11 | 0.08 | 0.05 | TRUE |
| 5 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | IL23R | 0.25 | 0.07 | lasso | 8 | 0.05 | 1.0e-02 | 6.0 | 5.3 | 1.1e-07 | -0.12 | 0.05 | 0.05 | TRUE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | MIER1 | 0.19 | 0.05 | blup | 58 | 0.06 | 1.7e-06 | 4.1 | 5.9 | 3.5e-09 | -0.25 | 0.79 | 0.08 | TRUE |