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chr1:149,854,324-152,008,309

Best TWAS P=3.54e-08 · Best GWAS P=7.1e-14 conditioned to 2e-11

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	RP11-316M1.12	0.23	0.46	enet	17	0.46	4.8e-42	-4.8	5.2	2.6e-07	0.01	0.94	0.06	FALSE
2	GTEx	Adrenal Gland	CTSS	0.12	0.13	lasso	9	0.08	7.0e-04	-4.8	-5.2	2.4e-07	-0.02	0.06	0.92	FALSE
3	GTEx	Brain Cerebellar Hemisphere	RP11-316M1.12	0.31	0.37	lasso	4	0.39	4.5e-11	-4.8	5.3	1.1e-07	0.03	0.05	0.95	FALSE
4	GTEx	Esophagus Gastroesophageal Junction	RP11-316M1.12	0.25	0.40	lasso	8	0.41	4.4e-16	-4.8	5.1	2.8e-07	0.02	0.06	0.94	FALSE
5	GTEx	Heart Left Ventricle	RP11-316M1.12	0.21	0.29	lasso	2	0.30	2.5e-16	-4.8	5.2	1.6e-07	0.01	0.86	0.14	FALSE
6	GTEx	Liver	RP11-316M1.12	0.27	0.33	lasso	5	0.37	2.9e-11	-4.8	5.1	3.1e-07	0.03	0.18	0.82	FALSE
7	GTEx	Nerve Tibial	GOLPH3L	0.33	0.52	lasso	5	0.50	1.6e-40	-5.2	-5.2	2.1e-07	-0.04	0.10	0.90	FALSE
8	GTEx	Prostate	RP11-316M1.12	0.16	0.23	enet	24	0.21	5.2e-06	-5.2	5.2	2.1e-07	0.04	0.05	0.94	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	RP11-316M1.12	0.19	0.37	lasso	2	0.38	7.6e-22	-4.9	5.1	3.1e-07	0.03	0.14	0.86	FALSE
10	GTEx	Skin Sun Exposed Lower leg	GOLPH3L	0.18	0.36	enet	48	0.39	4.7e-34	-4.9	-5.3	1.2e-07	-0.05	0.24	0.76	FALSE
11	GTEx	Spleen	RP11-54A4.2	0.29	0.10	lasso	9	0.04	3.8e-02	-4.8	5.4	6.1e-08	0.03	0.07	0.78	FALSE
12	GTEx	Testis	CTSK	0.07	0.01	enet	19	0.01	1.2e-01	-4.7	-5.4	6.1e-08	-0.02	0.08	0.80	FALSE
13	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HORMAD1	0.22	0.35	lasso	12	0.37	7.6e-33	-5.2	-5.3	1.5e-07	-0.04	0.02	0.98	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	HORMAD1	0.06	0.11	lasso	2	0.10	2.0e-20	-5.5	-5.5	3.5e-08	-0.04	0.03	0.97	TRUE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	HORMAD1	0.14	0.14	lasso	7	0.13	4.8e-08	-5.2	-5.2	2.6e-07	-0.05	0.02	0.98	FALSE
16	The Cancer Genome Atlas	Glioblastoma Multiforme	CTSS	0.08	0.03	blup	50	0.07	4.8e-03	-5.0	-5.2	2.3e-07	-0.03	0.03	0.66	FALSE
17	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GOLPH3L	0.02	0.02	blup	49	0.01	1.6e-02	-5.2	5.2	1.8e-07	0.03	0.03	0.67	FALSE
18	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CTSS	0.07	0.07	blup	50	0.07	6.4e-04	-5.5	-5.1	2.9e-07	-0.05	0.02	0.85	FALSE
19	The Cancer Genome Atlas	Prostate Adenocarcinoma	GOLPH3L	0.03	0.01	blup	49	0.01	2.2e-02	-5.2	5.3	1.4e-07	0.03	0.03	0.60	FALSE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	TDRKH	0.37	0.38	lasso	4	0.40	1.0e-44	-5.3	-5.2	1.7e-07	0.22	1.00	0.00	TRUE
21	The Cancer Genome Atlas	Rectum Adenocarcinoma	HORMAD1	0.19	0.14	blup	43	0.14	3.3e-04	-5.2	-5.2	1.6e-07	-0.04	0.03	0.91	FALSE
22	The Cancer Genome Atlas	Soft Tissue Sarcoma	HORMAD1	0.14	0.15	blup	44	0.15	3.2e-09	-5.2	-5.2	2.5e-07	-0.05	0.02	0.98	FALSE
23	The Cancer Genome Atlas	Skin Cutaneous Melanoma	HORMAD1	0.16	0.17	blup	44	0.16	4.4e-05	-4.9	-5.2	2.4e-07	-0.04	0.04	0.91	FALSE
24	The Cancer Genome Atlas	Stomach Adenocarcinoma	CTSS	0.04	0.04	blup	48	0.04	6.9e-04	-4.7	-5.2	1.9e-07	-0.02	0.02	0.89	FALSE
25	The Cancer Genome Atlas	Stomach Adenocarcinoma	HORMAD1	0.10	0.15	lasso	6	0.15	5.9e-11	-5.5	-5.4	5.4e-08	-0.04	0.03	0.97	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	CTSS	0.11	0.23	lasso	8	0.24	1.2e-22	-4.7	-5.2	2.3e-07	-0.03	0.80	0.20	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	HORMAD1	0.19	0.14	lasso	5	0.15	8.3e-15	-5.2	-5.2	1.7e-07	-0.04	0.11	0.89	FALSE
28	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CTSS	0.13	0.03	lasso	8	0.05	1.9e-02	-5.2	-5.1	3.0e-07	-0.06	0.02	0.58	FALSE