Best TWAS P=5.85e-13 · Best GWAS P=4.24e-17 conditioned to 7.27e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | POLR2E | 0.39 | 0.06 | lasso | 8 | 0.16 | 2.1e-08 | 5.2 | -7.2 | 5.9e-13 | -0.47 | 0.41 | 0.17 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | GPX4 | 0.37 | 0.20 | lasso | 9 | 0.23 | 4.3e-17 | 5.2 | 5.1 | 3.0e-07 | 0.63 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Prostate | GPX4 | 0.41 | 0.23 | lasso | 3 | 0.22 | 4.1e-06 | 5.2 | 6.4 | 1.8e-10 | 0.65 | 0.02 | 0.80 | FALSE |
| 4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | GPX4 | 0.08 | 0.01 | lasso | 7 | 0.02 | 4.7e-03 | 8.4 | 6.9 | 6.8e-12 | 0.87 | 0.00 | 0.97 | TRUE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ABCA7 | 0.05 | 0.02 | blup | 71 | 0.04 | 4.7e-05 | -4.9 | -5.6 | 1.9e-08 | -0.29 | 0.02 | 0.95 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GPX4 | 0.12 | 0.11 | lasso | 4 | 0.12 | 3.9e-13 | 5.2 | 5.4 | 5.8e-08 | 0.63 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | GPX4 | 0.17 | 0.03 | blup | 45 | 0.10 | 1.2e-05 | 5.2 | 5.9 | 2.9e-09 | 0.67 | 0.01 | 0.92 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GPX4 | 0.21 | 0.15 | lasso | 4 | 0.14 | 6.9e-15 | 5.2 | 5.2 | 2.1e-07 | 0.66 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | POLR2E | 0.06 | 0.00 | blup | 53 | 0.03 | 2.3e-04 | -2.2 | -5.6 | 2.5e-08 | -0.37 | 0.05 | 0.26 | FALSE |