[Hub]/) : Traits : Intelligence (Savage-Jansen 2018) :

chr22:30,390,990-32,057,501

Best TWAS P=3.61e-08 · Best GWAS P=6.2e-08 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous MORC2-AS1 0.14 0.12 lasso 4 0.11 3.2e-09 5.4 -5.4 8.1e-08 -1.00 0.01 0.99 FALSE
2 GTEx Artery Aorta MORC2-AS1 0.16 0.05 lasso 2 0.02 2.3e-02 5.4 -5.3 1.0e-07 -0.99 0.01 0.98 FALSE
3 GTEx Artery Tibial MORC2-AS1 0.17 0.09 lasso 4 0.07 5.2e-06 5.4 -5.4 5.3e-08 -1.00 0.01 0.99 FALSE
4 GTEx Brain Caudate basal ganglia EIF4HP2 0.38 0.20 lasso 6 0.10 6.5e-04 5.1 -5.3 9.3e-08 -0.98 0.02 0.98 FALSE
5 GTEx Brain Cerebellar Hemisphere EIF4HP2 0.28 0.18 enet 18 0.17 4.6e-05 5.1 -5.3 1.2e-07 -0.96 0.02 0.94 FALSE
6 GTEx Heart Left Ventricle MORC2-AS1 0.12 0.08 lasso 3 0.06 3.2e-04 5.4 -5.3 1.4e-07 -0.99 0.01 0.98 FALSE
7 GTEx Lung MORC2-AS1 0.12 0.09 lasso 6 0.08 8.3e-07 5.4 -5.2 2.2e-07 -0.96 0.01 0.99 FALSE
8 GTEx Muscle Skeletal MORC2-AS1 0.08 0.04 enet 17 0.05 5.3e-06 5.4 -5.1 2.8e-07 -0.91 0.01 0.98 FALSE
9 GTEx Nerve Tibial MORC2-AS1 0.25 0.20 lasso 8 0.19 2.0e-13 5.4 -5.4 6.3e-08 -1.00 0.01 0.99 FALSE
10 GTEx Skin Not Sun Exposed Suprapubic MORC2-AS1 0.19 0.09 lasso 3 0.06 2.2e-04 5.4 -5.4 8.0e-08 -0.99 0.01 0.98 FALSE
11 GTEx Skin Sun Exposed Lower leg MORC2-AS1 0.13 0.07 lasso 5 0.09 5.1e-08 5.4 -5.4 7.4e-08 -0.98 0.01 0.99 FALSE
12 GTEx Thyroid MORC2-AS1 0.16 0.08 enet 20 0.13 5.8e-10 5.0 -5.4 7.7e-08 -0.94 0.03 0.97 FALSE
13 METSIM Adipose MORC2 0.04 0.00 bslmm 396 0.01 8.8e-03 4.9 5.2 1.7e-07 0.64 0.03 0.59 FALSE
14 YFS Blood OSBP2 0.04 0.02 lasso 4 0.02 9.7e-07 5.2 -5.1 2.9e-07 -0.88 0.03 0.97 FALSE
15 The Cancer Genome Atlas Breast Invasive Carcinoma C22orf27 0.05 0.08 lasso 3 0.07 8.9e-15 5.4 -5.4 6.3e-08 -1.00 0.01 0.99 FALSE
16 The Cancer Genome Atlas Colon Adenocarcinoma C22orf27 0.07 0.06 lasso 2 0.05 5.0e-04 5.1 -5.4 8.0e-08 -0.97 0.01 0.98 FALSE
17 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C22orf27 0.09 0.03 blup 24 0.04 6.4e-05 5.1 -5.2 2.2e-07 -0.94 0.01 0.94 FALSE
18 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C22orf27 0.24 0.16 enet 11 0.17 2.6e-18 5.4 -5.4 6.2e-08 -0.96 0.01 0.99 FALSE
19 The Cancer Genome Atlas Brain Lower Grade Glioma C22orf27 0.09 0.07 blup 24 0.08 6.9e-09 5.4 -5.4 5.5e-08 -0.95 0.01 0.99 FALSE
20 The Cancer Genome Atlas Liver Hepatocellular Carcinoma C22orf27 0.23 0.13 blup 24 0.14 3.9e-07 5.4 -5.3 1.1e-07 -0.94 0.01 0.99 FALSE
21 The Cancer Genome Atlas Lung Adenocarcinoma C22orf27 0.08 0.07 blup 24 0.10 1.5e-11 5.4 -5.3 1.3e-07 -0.93 0.01 0.99 FALSE
22 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C22orf27 0.06 0.04 blup 24 0.06 4.5e-07 5.1 -5.1 2.7e-07 -0.91 0.01 0.99 FALSE
23 The Cancer Genome Atlas Pancreatic Adenocarcinoma C22orf27 0.12 0.15 lasso 3 0.14 2.3e-06 5.4 -5.3 1.1e-07 -1.00 0.01 0.98 FALSE
24 The Cancer Genome Atlas Prostate Adenocarcinoma C22orf27 0.20 0.14 blup 24 0.15 1.9e-15 5.0 -5.3 1.1e-07 -0.95 0.01 0.99 FALSE
25 The Cancer Genome Atlas Skin Cutaneous Melanoma C22orf27 0.19 0.15 lasso 1 0.14 1.8e-04 5.1 -5.1 2.7e-07 -0.99 0.01 0.75 FALSE
26 The Cancer Genome Atlas Thyroid Carcinoma C22orf27 0.26 0.21 enet 11 0.24 1.3e-22 5.4 -5.5 3.6e-08 -0.95 0.01 0.99 TRUE
27 The Cancer Genome Atlas Thyroid Carcinoma MORC2 0.05 0.01 blup 30 0.03 3.3e-04 5.0 5.2 2.3e-07 0.88 0.01 0.68 FALSE