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chr22:30,390,990-32,057,501

Best TWAS P=3.61e-08 · Best GWAS P=6.2e-08 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	MORC2-AS1	0.14	0.12	lasso	4	0.11	3.2e-09	5.4	-5.4	8.1e-08	-1.00	0.01	0.99	FALSE
2	GTEx	Artery Aorta	MORC2-AS1	0.16	0.05	lasso	2	0.02	2.3e-02	5.4	-5.3	1.0e-07	-0.99	0.01	0.98	FALSE
3	GTEx	Artery Tibial	MORC2-AS1	0.17	0.09	lasso	4	0.07	5.2e-06	5.4	-5.4	5.3e-08	-1.00	0.01	0.99	FALSE
4	GTEx	Brain Caudate basal ganglia	EIF4HP2	0.38	0.20	lasso	6	0.10	6.5e-04	5.1	-5.3	9.3e-08	-0.98	0.02	0.98	FALSE
5	GTEx	Brain Cerebellar Hemisphere	EIF4HP2	0.28	0.18	enet	18	0.17	4.6e-05	5.1	-5.3	1.2e-07	-0.96	0.02	0.94	FALSE
6	GTEx	Heart Left Ventricle	MORC2-AS1	0.12	0.08	lasso	3	0.06	3.2e-04	5.4	-5.3	1.4e-07	-0.99	0.01	0.98	FALSE
7	GTEx	Lung	MORC2-AS1	0.12	0.09	lasso	6	0.08	8.3e-07	5.4	-5.2	2.2e-07	-0.96	0.01	0.99	FALSE
8	GTEx	Muscle Skeletal	MORC2-AS1	0.08	0.04	enet	17	0.05	5.3e-06	5.4	-5.1	2.8e-07	-0.91	0.01	0.98	FALSE
9	GTEx	Nerve Tibial	MORC2-AS1	0.25	0.20	lasso	8	0.19	2.0e-13	5.4	-5.4	6.3e-08	-1.00	0.01	0.99	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	MORC2-AS1	0.19	0.09	lasso	3	0.06	2.2e-04	5.4	-5.4	8.0e-08	-0.99	0.01	0.98	FALSE
11	GTEx	Skin Sun Exposed Lower leg	MORC2-AS1	0.13	0.07	lasso	5	0.09	5.1e-08	5.4	-5.4	7.4e-08	-0.98	0.01	0.99	FALSE
12	GTEx	Thyroid	MORC2-AS1	0.16	0.08	enet	20	0.13	5.8e-10	5.0	-5.4	7.7e-08	-0.94	0.03	0.97	FALSE
13	METSIM	Adipose	MORC2	0.04	0.00	bslmm	396	0.01	8.8e-03	4.9	5.2	1.7e-07	0.64	0.03	0.59	FALSE
14	YFS	Blood	OSBP2	0.04	0.02	lasso	4	0.02	9.7e-07	5.2	-5.1	2.9e-07	-0.88	0.03	0.97	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	C22orf27	0.05	0.08	lasso	3	0.07	8.9e-15	5.4	-5.4	6.3e-08	-1.00	0.01	0.99	FALSE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	C22orf27	0.07	0.06	lasso	2	0.05	5.0e-04	5.1	-5.4	8.0e-08	-0.97	0.01	0.98	FALSE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C22orf27	0.09	0.03	blup	24	0.04	6.4e-05	5.1	-5.2	2.2e-07	-0.94	0.01	0.94	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C22orf27	0.24	0.16	enet	11	0.17	2.6e-18	5.4	-5.4	6.2e-08	-0.96	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	C22orf27	0.09	0.07	blup	24	0.08	6.9e-09	5.4	-5.4	5.5e-08	-0.95	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C22orf27	0.23	0.13	blup	24	0.14	3.9e-07	5.4	-5.3	1.1e-07	-0.94	0.01	0.99	FALSE
21	The Cancer Genome Atlas	Lung Adenocarcinoma	C22orf27	0.08	0.07	blup	24	0.10	1.5e-11	5.4	-5.3	1.3e-07	-0.93	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C22orf27	0.06	0.04	blup	24	0.06	4.5e-07	5.1	-5.1	2.7e-07	-0.91	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C22orf27	0.12	0.15	lasso	3	0.14	2.3e-06	5.4	-5.3	1.1e-07	-1.00	0.01	0.98	FALSE
24	The Cancer Genome Atlas	Prostate Adenocarcinoma	C22orf27	0.20	0.14	blup	24	0.15	1.9e-15	5.0	-5.3	1.1e-07	-0.95	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Skin Cutaneous Melanoma	C22orf27	0.19	0.15	lasso	1	0.14	1.8e-04	5.1	-5.1	2.7e-07	-0.99	0.01	0.75	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	C22orf27	0.26	0.21	enet	11	0.24	1.3e-22	5.4	-5.5	3.6e-08	-0.95	0.01	0.99	TRUE
27	The Cancer Genome Atlas	Thyroid Carcinoma	MORC2	0.05	0.01	blup	30	0.03	3.3e-04	5.0	5.2	2.3e-07	0.88	0.01	0.68	FALSE