Hub : Genes

MORC2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.3210	0.0750	1.4e-06	0.134	NA	0.154	NA	0.183	1.6e-06	NA	2.5e-07	NA	1.6e-08
2	METSIM	Adipose	0.0405	0.0209	9.7e-03	0.000	0.009	0.008	0.01	-0.001	3.9e-01	1.4e-02	2.2e-02	8.8e-03	5.3e-01
3	YFS	Blood	0.1038	0.0237	5.6e-17	0.051	0.070	0.067	0.07	0.067	2.3e-16	8.3e-22	4.8e-21	7.1e-22	3.8e-21
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0637	0.0522	2.6e-03	0.018	0.023	0.029	NA	0.020	3.5e-03	1.2e-03	2.7e-04	NA	2.1e-03
5	TCGA	Pancreatic Adenocarcinoma	0.0740	0.0610	8.0e-03	0.038	0.046	0.057	NA	0.039	1.0e-02	5.3e-03	2.1e-03	NA	9.4e-03
6	TCGA	Thyroid Carcinoma	0.0510	0.0350	2.6e-03	0.009	0.033	0.025	NA	0.018	4.3e-02	3.3e-04	1.7e-03	NA	6.7e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	1.2	0.1	-0.5	0.5	1.1	1.1	-0.2
Bipolar Disorder or Schizophrenia	1.4	3.5	9.7	1.8	-3.1	-1.2	-1.3	-1.0	-2.0
Depressed Affect (Nagel 2018)	0.1	0.2	0.7	-0.4	-0.9	0.2	0.2	0.2	-0.0
Depression (Nagel 2018)	0.6	1.0	1.8	0.4	-1.0	-1.0	-1.0	-0.9	-1.3
Intelligence (Savage-Jansen 2018)	7.1	21.9	27.4	-4.3	5.2	4.4	4.2	4.7	5.2
Neuroticism (Nagel 2018)	0.6	1.5	2.1	0.7	-1.2	-1.5	-1.0	-1.3	-1.4
Schizophrenia (2018)	3.1	6.4	13.1	2.3	-3.6	-2.0	-2.5	-2.1	-2.3
Schizophrenia vs Biploar Disorder	3.2	4.3	7.0	1.4	-2.2	-2.0	-2.6	-2.2	-1.8
Worry (Nagel 2018)	0.5	1.1	2.5	0.5	-1.2	-1.6	-0.4	-0.6	-1.3
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.4	-0.3	0.4	0.3	0.3	0.4
Alzheimer’s Disease (in father)	2.4	2.6	5.3	2.0	-2.3	-0.8	-1.6	-1.8	0.0
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	0.9	-0.8	0.0	-0.4	-0.5	0.5
Crohns Disease (2017)	0.7	1.6	2.5	-1.6	1.4	1.1	1.2	1.6	0.6
Irritable Bowel Disease (IBD)	0.5	1.1	2.7	-1.6	1.7	0.6	0.2	1.0	-0.1
Ulcerative Colitis (UC)	0.2	0.4	0.9	-0.9	0.9	0.0	-0.4	0.1	-0.6
Major Depression (MDD)	0.2	0.2	0.9	-0.3	-0.9	0.5	-0.1	0.3	0.3
Reaction Time	1.4	2.7	6.2	1.2	-2.5	-1.8	-0.9	-1.1	-1.8
Verbal and Numeric Reasoning (VNR)	5.5	13.3	17.7	-3.0	4.2	3.7	3.0	3.8	4.0
Breast Cancer	0.6	1.4	2.8	1.2	-1.7	-1.4	-0.8	-0.8	-1.1
Ovarian Cancer	0.5	0.7	1.6	0.2	0.5	-0.9	-0.6	-1.0	-1.3
Prostate Cancer	3.0	4.2	6.7	-1.6	2.2	2.1	2.0	1.5	2.6
Age at First Birth	0.2	0.3	1.2	0.1	1.1	-0.3	0.5	0.2	-0.4
Bipolar Disorder (2011)	0.4	0.3	1.1	1.1	-0.5	0.4	0.0	-0.6	-0.3
Body Mass Index (BMI) (2010)	1.6	2.2	4.7	1.0	-1.5	-2.0	-0.7	-0.9	-2.2
Coronary Artery Disease (CAD)	0.1	0.1	0.6	0.1	-0.8	0.1	0.4	0.3	-0.1
Crohns Disease (2012)	0.9	1.4	4.9	-0.7	2.2	0.9	1.1	1.1	0.2
Mean Putamen Volume	0.2	0.3	0.8	0.9	-0.4	0.7	0.5	-0.2	-0.1
Fasting Glucose	0.2	0.3	1.3	1.1	-0.4	-0.2	-0.0	-0.4	0.3
HbA1C	0.5	0.6	1.4	-1.2	-0.1	0.6	0.9	1.0	-0.0
HDL Cholesterol	0.5	0.9	2.6	-0.5	1.6	1.4	0.1	-0.2	0.7
LDL Cholesterol	0.3	0.5	1.8	-1.4	0.1	0.7	0.3	0.8	0.1
Lupus	0.7	1.0	2.5	1.6	-1.6	-0.6	-0.5	-0.4	-0.4
Neuroticism (2016)	0.7	1.0	2.1	1.3	-0.8	-0.5	-1.1	-1.5	-0.4
Primary Biliary Cirrhosis	0.6	0.8	1.8	-1.3	0.6	-0.2	0.9	1.1	-0.9
Rheumatoid Arthritis	2.4	3.3	4.5	1.5	-2.1	-1.6	-1.8	-1.9	-1.8
Schizophrenia (2014)	5.1	11.3	20.6	2.8	-4.5	-3.2	-3.0	-2.7	-3.6
Triglycerides	0.3	0.5	1.8	-0.8	1.3	0.4	-0.1	0.6	0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.6	-0.8	-0.0	0.5	0.1	0.3	-0.0
Ulcerative Colitis	0.3	0.4	1.5	-0.4	1.2	0.6	-0.1	0.4	0.1
Blood Eosinophil Count	1.0	7.9	40.7	1.6	-6.4	-1.5	-0.3	-1.3	-0.1
Blood Platelet Count	1.7	20.2	36.4	6.0	-3.1	-2.9	-5.1	-5.9	-2.6
Blood Red Count	0.1	0.7	1.8	0.6	-0.9	0.4	1.4	0.8	-0.5
Blood White Count	0.2	1.3	2.6	0.7	1.1	-0.4	-1.6	-0.8	-1.5
Heel T-Score	1.0	7.7	14.6	-3.3	1.9	1.9	3.1	3.8	2.1
BMI	0.3	1.6	6.4	0.6	-2.5	-0.8	-0.8	-0.7	-0.9
Height	0.3	6.1	16.2	1.6	-1.7	-4.0	-2.2	-1.8	-2.6
Waist Hip Ratio (WHR)	1.0	4.4	9.1	-2.2	3.0	1.1	1.9	2.2	1.7
Systolic Blood Pressure	0.6	2.8	5.1	-2.1	1.7	2.3	0.6	0.6	1.9
Smoking Status	0.2	0.5	1.6	-0.3	1.3	-0.6	-0.5	0.1	-0.6
Allergy or Eczema	0.3	0.7	1.8	0.2	0.9	0.3	1.3	1.2	0.4
Cardiovascular Disease	0.4	1.3	3.9	-2.0	1.0	0.7	-0.0	0.4	1.4
Hypothyroidism (self reported)	0.4	0.8	2.1	-1.4	-1.0	0.2	1.0	0.8	0.3
Respiratory disease	0.3	0.6	1.6	0.2	-1.3	-0.3	0.9	0.8	-0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.8	-0.4	1.7	0.3	0.4	-0.4	0.3
Lung FEV1/FVC ratio	2.0	10.1	17.9	-2.9	2.5	2.6	4.2	3.5	3.1
Lung FVC	0.6	3.1	9.4	0.7	-0.7	-3.1	-0.5	-0.9	-2.7
Neuroticism	0.8	1.9	3.0	1.2	-1.6	-1.7	-0.8	-1.0	-1.7
Chronotype (morning person)	0.1	0.3	0.9	0.2	-0.9	-0.4	-0.4	-0.3	-0.6
Hair Pigment	0.0	0.7	2.1	0.0	1.4	0.4	0.3	1.0	-0.9
Tanning	0.1	0.8	3.1	-0.3	0.2	-1.1	-0.6	0.4	-1.8
Hand grip strength (left)	0.5	1.3	5.1	0.8	-2.3	-1.2	-0.1	-0.2	-0.9
Number of treatments/medications taken	4.5	8.1	12.9	1.6	-2.7	-3.6	-3.0	-2.8	-3.0
Average weekly spirits intake	0.1	0.1	0.5	-0.1	0.7	0.0	0.1	0.4	-0.0
Sensitivity / hurt feelings	0.5	0.9	1.9	1.4	-1.0	-0.8	-0.7	-1.1	-0.3
Frequency of depressed mood in last 2 weeks	1.2	1.6	3.1	-0.4	-1.6	-1.8	-1.0	-0.4	-1.7
Hearing difficulty/problems: Yes	1.5	2.3	3.9	-1.1	1.6	2.0	1.2	1.4	1.7
Relative age of first facial hair	0.8	1.6	2.3	1.1	-0.8	-1.4	-1.5	-1.5	-1.1
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	3.7	0.7	-0.3	-1.2	-1.9	-1.8	-0.8
Ever used hormone-replacement therapy (HRT)	2.1	2.6	5.3	2.3	-0.5	-0.7	-2.2	-2.2	0.1
Ever had hysterectomy (womb removed)	1.3	1.4	4.4	0.7	-2.1	-0.8	-0.7	-1.5	-0.5
Systolic blood pressure, automated reading	0.3	0.8	3.3	0.1	0.7	1.8	-0.2	-0.4	0.9
Eye problems/disorders: Diabetes related eye disease	3.3	3.6	7.6	1.2	-0.3	-1.9	-2.8	-2.4	-1.7
Angina	0.3	0.3	1.2	-1.1	-0.3	0.6	0.2	0.1	0.5
Medication for hormone replacement therapy	0.9	1.0	1.7	-0.8	0.1	1.0	1.3	1.1	1.1
Vitamin and mineral supplements	1.4	1.9	3.1	-1.6	0.5	1.6	1.8	1.3	1.2
Supplements: Zinc	1.0	1.1	5.7	-0.8	2.4	0.4	-0.0	0.5	0.1
Medication: Co-codamol	1.0	1.1	2.8	0.3	-0.2	-1.4	-1.7	-0.8	-1.0
Medication: Metformin	0.7	1.0	5.1	-0.7	2.3	-0.2	-0.6	-0.4	-0.3
Diabetes (father)	0.3	0.4	0.9	-0.9	0.6	-0.7	-0.4	0.0	-0.7
Diabetes (mother)	3.5	4.5	6.2	1.3	-2.2	-2.1	-2.5	-2.5	-2.0
Severe depression (siblings)	0.6	0.7	2.0	-0.0	-0.9	1.0	0.2	-0.1	1.4
Pack years adult smoking proportion	0.1	0.2	0.5	-0.4	0.3	0.4	0.3	0.7	0.1
Impedance of leg (right)	0.1	0.5	1.7	0.0	1.3	-0.2	-0.8	-0.8	-0.5
Leg fat-free mass (left)	0.5	2.6	5.9	1.2	-2.4	-2.1	-0.9	-0.7	-1.6
Trunk fat percentage	1.7	7.0	8.7	3.0	-2.3	-2.1	-2.9	-2.9	-2.6
Hand grip strength (right)	0.7	1.8	5.9	1.1	-2.4	-1.3	-0.2	-0.6	-1.2
Townsend deprivation index at recruitment	0.5	0.7	2.9	0.1	-0.4	0.1	-1.7	-0.8	0.4
Current tobacco smoking	0.4	0.7	2.3	-0.9	1.5	0.5	-0.3	0.4	0.8
Average weekly fortified wine intake	0.4	0.5	1.5	-0.4	0.1	1.1	0.2	0.4	1.2
Maternal smoking around birth	0.1	0.1	0.3	-0.4	0.5	-0.0	0.6	0.2	0.1
Fed-up feelings	0.4	0.7	2.5	-0.7	-1.6	0.4	0.5	0.7	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	1.6	0.9	-0.7	-1.1	-1.1	-0.9	-1.3
Relative age voice broke	0.8	1.3	2.5	0.8	-0.8	-1.4	-1.1	-0.9	-1.6
Taking other prescription medications	1.0	1.5	3.2	-0.1	-1.2	-1.8	-1.0	-1.3	-1.4
Age when periods started (menarche)	3.9	9.3	15.5	3.9	-1.0	-2.9	-2.5	-3.1	-3.9
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	5.3	-0.9	0.6	2.0	1.4	1.3	2.3
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	7.5	-2.4	0.1	0.9	2.0	2.7	1.2
Tinnitus: Yes, but not now, but have in the past	1.7	1.9	3.7	0.7	-1.9	-0.9	-1.7	-1.7	-0.7
Qualifications: CSEs or equivalent	2.6	3.4	5.6	1.3	-1.9	-2.4	-1.4	-1.9	-2.1
Serious illness, injury or assault to yourself	1.0	1.2	3.9	-2.0	1.1	0.9	0.3	1.1	-0.0
High blood pressure	1.0	2.9	4.8	-1.7	2.0	2.0	0.5	1.1	2.2
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.9	0.3	0.9	0.3	0.5	0.6	0.6
Multivitamins +/- minerals	0.5	0.7	1.7	0.5	-0.3	-0.9	-1.3	-1.0	-0.4
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.2	0.3	-0.5	-0.1	0.0	-0.4
Supplements: Glucosamine	0.4	0.5	2.1	1.5	-0.1	-0.5	-0.3	-0.1	-0.5
Diverticular disease/diverticulitis (self-reported)	1.1	1.2	2.7	-0.9	0.7	1.4	1.1	0.6	1.6
Medication: Atenolol	0.4	0.5	1.4	-1.2	0.8	0.5	-0.1	0.2	0.9
Medication: Levothyroxine sodium	0.2	0.4	1.1	-0.5	-1.0	-0.6	0.4	0.2	-0.8
Sitting height	0.1	0.7	1.9	-0.2	-0.2	0.4	1.0	1.4	1.1
Chronic bronchitis/emphysema (father)	1.8	2.1	4.6	0.4	0.2	-2.1	-1.7	-1.4	-1.7
High blood pressure (mother)	1.2	1.7	4.9	-2.2	1.3	0.4	0.8	1.6	0.5
Body mass index (BMI)	0.5	2.2	5.9	1.3	-2.4	-1.2	-1.3	-0.9	-1.3
Impedance of leg (left)	0.1	0.6	1.6	0.2	1.3	-0.1	-0.8	-0.8	-0.6
Leg predicted mass (left)	0.5	2.5	5.9	1.2	-2.4	-2.0	-0.8	-0.6	-1.6
Trunk fat mass	1.6	6.7	7.4	2.6	-2.6	-2.5	-2.7	-2.5	-2.7
Waist circumference	0.6	2.0	2.6	1.3	-1.6	-1.6	-1.4	-1.1	-1.5
Number of incorrect matches in round	0.8	1.3	3.1	1.2	-0.7	-0.6	-1.2	-1.8	-0.9
Past tobacco smoking	0.3	0.5	1.0	-0.6	-0.2	1.0	0.7	0.4	1.0
Alcohol usually taken with meals	2.3	3.8	6.5	-2.6	2.0	2.1	1.8	1.6	1.4
Nervous feelings	0.5	0.9	2.9	1.1	-1.7	-0.8	-0.2	-0.7	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	0.1	-0.7	-0.9	-0.5	-0.4	-1.1
Hearing difficulty/problems with background noise	0.3	0.4	1.3	0.3	0.2	-0.1	-1.1	-1.0	-0.4
Hair/balding pattern: Pattern 2	0.4	0.5	1.8	-1.0	1.3	0.2	0.3	0.4	0.2
Had menopause	1.8	2.2	6.3	1.5	0.5	0.1	-2.1	-2.5	0.2
Had other major operations	2.7	3.4	4.4	1.8	-1.9	-1.8	-2.1	-1.9	-1.6
Forced vital capacity (FVC)	1.2	4.6	15.5	0.6	-1.6	-3.9	-0.7	-0.7	-2.9
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	4.2	-1.5	-0.0	0.4	1.5	2.1	0.8
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	5.0	2.1	-0.9	-2.0	-1.6	-1.8	-2.2
Qualifications: None of the above	2.0	4.3	6.1	1.8	-2.0	-1.9	-2.5	-2.5	-1.6
Financial difficulties in last 2 years	0.6	0.9	1.9	-0.4	-0.5	-1.3	-1.4	-0.8	-0.6
Mouth/teeth dental problems	0.3	0.5	1.0	-0.8	0.8	0.3	0.6	1.0	-0.2
Heart attack	0.1	0.2	0.3	-0.4	-0.6	-0.5	0.5	0.3	-0.2
Allergy	0.1	0.3	1.4	-1.2	0.3	0.3	0.2	0.0	0.2
Pain all over the body in last month	0.0	0.0	0.1	-0.0	0.4	-0.1	0.1	-0.4	0.0
Diabetes (self-reported)	0.6	1.0	4.4	-0.8	2.1	-0.1	-0.3	-0.8	0.1
Hayfever/allergic rhinitis (self-reported)	3.4	4.5	6.1	-2.5	1.8	1.7	1.9	2.4	2.2
Medication: Ramipril	0.2	0.2	0.8	-0.9	-0.5	-0.2	-0.3	0.2	-0.2
Medication: Simvastatin	0.2	0.3	0.7	-0.8	0.4	0.3	-0.5	0.2	0.8
Fluid intelligence score	2.2	4.6	7.1	-1.7	2.5	2.3	1.4	2.0	2.7
Illnesses of siblings	0.2	0.3	1.1	0.6	-1.0	0.4	0.3	0.0	0.1
Neuroticism score	0.4	0.7	2.0	0.7	-1.4	-1.0	-0.0	-0.4	-0.9
Weight	1.0	5.1	8.6	2.0	-2.9	-2.5	-2.0	-1.6	-2.3
Impedance of arm (right)	0.3	1.5	4.0	2.0	0.1	0.2	-1.1	-1.9	-0.6
Arm fat percentage (right)	1.0	4.1	7.4	2.1	-2.7	-1.3	-1.9	-1.9	-1.9
Trunk fat-free mass	0.2	1.4	3.9	0.1	-2.0	-1.8	-0.0	0.4	-1.0
Hip circumference	2.2	9.7	12.7	2.9	-3.6	-2.7	-3.4	-3.0	-3.0
Time employed in main current job	5.2	5.9	11.6	1.7	-1.2	-3.4	-2.1	-2.3	-3.2
Alcohol intake versus 10 years previously	0.9	1.4	2.7	0.6	-1.4	-1.7	-1.0	-0.7	-1.4
Father’s age at death	0.8	1.1	3.9	0.8	2.0	0.8	-1.0	-0.4	0.5
Worrier / anxious feelings	4.1	7.8	11.2	2.7	-2.2	-3.3	-2.4	-2.6	-3.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	3.8	-1.9	0.1	0.4	0.0	1.5	0.7
Falls in the last year	0.3	0.4	0.7	0.5	0.1	-0.2	0.7	0.9	-0.8
Hair/balding pattern: Pattern 3	0.3	0.4	1.0	0.3	-0.5	-0.2	-1.0	-1.0	-0.5
Number of live births	0.5	0.6	2.0	-0.3	0.5	-0.3	1.4	1.2	-0.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	7.0	-0.6	-0.8	-2.6	0.8	0.7	-1.6
Pulse rate	0.4	0.6	1.6	0.5	-0.4	-1.3	-0.8	-0.5	-1.0
Happiness	1.0	1.2	3.3	0.5	-0.5	-1.6	-0.7	-0.5	-1.8
Noisy workplace	0.3	0.4	1.0	-0.4	-0.7	0.5	1.0	0.3	0.4
Qualifications: A levels/AS levels or equivalent	2.3	5.0	8.2	-1.8	2.9	1.4	2.6	2.8	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	4.5	-1.3	2.1	1.0	0.8	1.2	1.4
Mouth/teeth dental problems: Dentures	0.3	0.6	1.2	0.5	-1.1	-0.5	-0.8	-1.0	-0.3
Asthma	0.2	0.4	1.1	1.0	-0.9	-0.0	0.4	0.3	0.0
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	3.2	1.0	-1.8	-1.7	-1.7	-1.1	-1.4
Medication: Cholesterol lowering	0.2	0.3	0.7	-0.2	0.3	0.0	-0.8	-0.5	0.7
Depression (self-reported)	1.1	1.3	3.1	-0.9	0.4	0.8	1.7	1.8	0.7
Medication: Lansoprazole	1.2	1.4	3.3	-0.0	-0.7	-1.8	-0.9	-0.9	-1.7
Prospective memory result	0.3	0.4	0.7	0.5	0.4	-0.7	-0.8	-0.6	-0.6
Lung cancer (father)	0.4	0.4	0.8	-0.7	0.9	-0.7	-0.6	0.0	-0.6
Illnesses of mother	1.4	1.8	5.5	2.4	-1.7	-0.9	-0.4	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	4.7	-0.9	-1.1	-2.2	1.0	0.4	-1.6
Pulse wave Arterial Stiffness index	0.7	0.9	1.3	1.0	-0.3	-1.0	-0.9	-1.1	-1.1
Impedance of arm (left)	0.3	1.2	3.4	1.8	0.5	0.5	-0.7	-1.7	0.0
Arm fat mass (right)	1.3	5.3	9.5	2.1	-3.1	-2.2	-2.0	-1.9	-2.4
Trunk predicted mass	0.2	1.4	4.1	0.1	-2.0	-1.8	0.0	0.4	-1.0
Standing height	0.4	4.1	9.2	1.9	-1.2	-3.0	-1.7	-1.6	-2.3
Length of working week for main job	0.4	0.4	1.1	0.2	-1.1	-0.3	0.0	0.5	-1.1
Exposure to tobacco smoke at home	3.9	4.3	8.1	1.6	-0.6	-2.9	-2.0	-1.9	-2.8
Breastfed as a baby	5.2	6.4	8.8	2.7	-1.6	-2.9	-2.5	-3.0	-2.2
Tense / ‘highly strung’	1.7	2.8	4.4	-1.7	-0.1	1.9	2.1	1.6	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	-1.0	-0.6	-0.1	-0.4	0.6	0.2
Hair/balding pattern: Pattern 4	0.8	1.9	3.3	1.2	-1.1	-1.8	-1.0	-1.4	-1.6
Birth weight of first child	0.1	0.2	0.6	0.6	-0.8	0.2	0.3	0.3	0.3
Peak expiratory flow (PEF)	0.5	1.1	2.7	-1.2	-0.3	-0.6	1.6	1.5	0.3
Pulse wave reflection index	0.1	0.1	0.4	0.3	0.6	0.4	0.3	-0.0	-0.1
Ever highly irritable/argumentative for 2 days	2.3	2.8	4.6	1.5	-1.5	-2.0	-1.2	-1.4	-2.1
Loud music exposure frequency	0.7	0.7	1.6	0.1	0.6	1.3	0.8	0.7	1.2
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.9	-1.1	2.0	1.2	1.0	1.3	1.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	-0.3	-0.1	0.6	0.9	0.7	0.9
Blood clot in the leg (DVT)	3.0	3.9	6.5	1.7	-2.6	-2.1	-1.8	-2.0	-1.6
Medication: Paracetamol	0.2	0.3	0.6	0.2	-0.8	-0.8	-0.6	0.2	-0.2
Headache pain in last month	0.1	0.2	0.6	-0.0	-0.5	-0.8	0.6	-0.1	-0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	0.8	-0.8	0.2	0.8	0.0	-0.2
Glaucoma (self-reported)	0.5	0.6	3.2	-0.3	1.8	-0.2	-0.2	-0.2	-0.2
Gout (self-reported)	0.7	1.0	1.6	-1.1	1.3	0.6	1.0	1.1	0.9
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.8	-1.0	-1.4	-0.5	0.8	0.3	-0.6
Medication: Amlodipine	0.4	0.6	1.7	-1.3	-0.8	-0.5	-0.2	0.8	-0.5
Medication: Ventolin 100micrograms inhaler	3.4	4.3	7.6	2.8	-2.5	-1.6	-1.5	-2.0	-1.8
Birth weight	1.0	2.1	4.2	-1.3	0.6	1.6	2.1	1.4	1.3
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.9	-1.4	0.6	0.6	0.0	0.2	0.7
High blood pressure (siblings)	0.4	0.6	1.1	-1.0	0.2	0.6	0.7	0.8	1.0
Forced vital capacity (FVC), Best measure	1.6	5.8	14.8	1.3	-2.4	-3.8	-0.9	-1.5	-3.1
Body fat percentage	1.5	5.9	7.1	2.4	-2.4	-2.0	-2.7	-2.6	-2.5
Leg fat percentage (right)	1.1	4.0	6.1	1.4	-1.8	-2.1	-2.2	-1.8	-2.5
Arm fat-free mass (right)	0.3	1.6	4.6	0.0	-1.6	-2.1	-0.3	0.2	-1.4
Exposure to tobacco smoke outside home	4.2	5.6	8.7	1.9	-2.7	-2.5	-2.3	-1.8	-2.9
Comparative body size at age 10	0.8	2.2	3.7	-1.0	0.2	1.9	1.5	1.6	1.9
Number of full brothers	0.4	0.5	1.9	-0.4	1.4	0.2	0.6	0.5	0.6
Worry too long after embarrassment	2.4	4.1	5.4	1.6	-1.8	-2.3	-2.1	-2.2	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.4	-0.4	-0.2	1.4	0.3	0.9	1.5
Wheeze or whistling in the chest in last year	4.0	7.1	14.0	1.7	-2.2	-3.4	-2.3	-1.9	-3.7
Number of children fathered	2.4	2.7	4.8	-2.1	0.9	1.0	2.2	2.1	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	0.2	-0.5	0.6	0.1	-0.0	0.3
Age at first live birth	0.5	0.9	2.0	-0.2	1.3	0.2	1.4	1.1	0.4
Pulse wave peak to peak time	0.4	0.4	0.9	-0.8	0.0	0.6	0.6	0.9	0.7
Health satisfaction	1.6	2.1	3.9	-0.0	-1.3	-2.0	-1.7	-1.1	-1.6
Shortness of breath walking on level ground	0.8	1.0	2.2	-0.6	-1.0	-1.1	-0.8	-0.5	-1.5
Qualifications: College or University degree	1.2	3.6	5.3	-0.8	2.0	2.2	1.9	1.8	2.3
Eye problems/disorders: None of the above	0.2	0.3	0.6	0.2	-0.8	0.6	-0.2	0.5	0.7
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	-0.3	0.8	0.4	-0.6	0.2	0.6
Emphysema/chronic bronchitis	0.5	0.6	1.8	0.5	-0.2	-0.9	-0.7	-0.5	-1.3
Medication for pain relief, constipation, heartburn	0.8	1.4	3.6	-0.4	1.3	1.9	1.0	0.5	1.3
Neck or shoulder pain in last month	0.1	0.2	0.5	-0.7	-0.3	-0.0	-0.2	0.5	0.0
Medication: Blood pressure	0.5	0.9	2.7	-1.6	1.4	-0.4	-0.7	0.6	-0.2
Angina (self-reported)	0.4	0.5	1.5	-1.2	-0.5	0.7	0.4	0.0	0.7
Migraine (self-reported)	1.7	2.1	4.4	-1.4	0.5	1.1	2.1	2.0	0.9
Medication: Ibuprofen	2.3	2.7	4.1	1.2	-2.0	-1.8	-1.9	-1.2	-1.6
Medication: Allopurinol	1.4	1.9	3.4	-1.2	1.9	1.5	1.1	1.0	1.5
Medication: Omeprazole	1.4	1.6	2.5	0.6	-1.4	-1.3	-1.5	-1.6	-1.0
Medication: Seretide 50 evohaler	0.2	0.2	0.6	-0.5	-0.0	-0.4	0.1	0.8	-0.5
Mean time to correctly identify matches	0.7	1.3	2.7	0.8	-1.6	-1.1	-1.1	-1.0	-1.1
Heart disease (mother)	1.1	1.4	2.5	-1.6	0.9	1.2	1.0	1.2	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.8	-0.6	0.2	0.9	0.7	0.8	0.8
Whole body fat mass	1.5	6.1	7.2	2.4	-2.7	-2.4	-2.5	-2.2	-2.6
Leg fat mass (right)	1.4	5.4	7.5	1.8	-2.6	-2.6	-2.2	-1.8	-2.7
Arm predicted mass (right)	0.3	1.4	4.1	0.2	-1.7	-2.0	-0.4	0.1	-1.3
Pulse rate, automated reading	0.1	0.4	1.5	0.2	1.2	0.7	-0.2	0.1	0.4
Alcohol intake frequency.	0.4	1.0	3.9	-0.5	-2.0	-1.1	0.0	-0.1	-0.8
Comparative height size at age 10	0.1	0.5	2.3	-0.1	0.5	0.6	0.2	0.1	1.5
Number of full sisters	0.9	1.1	1.9	-1.2	0.4	0.9	1.4	1.0	1.1
Suffer from ‘nerves’	0.3	0.5	1.2	-0.8	-0.8	-1.1	-0.1	-0.0	-0.8
Overall health rating	1.3	2.8	4.9	-0.2	-1.6	-2.2	-2.0	-1.2	-1.9
Chest pain or discomfort	1.0	1.4	2.3	-1.4	0.8	1.5	0.7	1.1	1.4
Had major operations	0.2	0.3	0.6	-0.8	-0.2	-0.3	0.6	0.7	0.1
Age at last live birth	0.5	0.7	1.7	0.8	1.0	-0.5	1.3	0.2	-0.8
Family relationship satisfaction	0.1	0.2	0.4	0.7	-0.4	-0.3	-0.0	0.1	-0.6
Leg pain on walking	2.0	2.5	5.1	-0.2	-0.2	-2.3	-2.2	-1.5	-1.7
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	-0.4	0.6	0.2	0.5	0.5	-0.1
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.1	-0.3	-0.3	-0.3	-0.1	0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.6	0.8	-0.2	0.0	0.5	-0.1	-0.3
Medication: Aspirin	0.4	0.5	0.9	0.2	0.8	-0.9	0.6	0.5	-1.0
Supplements: Vitamin C	0.2	0.3	0.7	0.8	0.2	-0.5	-0.7	-0.4	-0.2
Knee pain experienced in last month	3.5	5.4	9.8	2.6	-1.5	-1.9	-3.1	-2.9	-1.4
Hypertension (Self-reported)	0.9	2.4	4.0	-1.7	2.0	1.6	0.2	0.9	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.3	-0.7	0.6	0.5	1.5	1.4	0.6
Illnesses of father: Heart disease	0.3	0.4	1.6	-0.2	-0.6	0.2	1.3	0.5	0.4
Illnesses of siblings: Diabetes	0.6	0.7	2.2	-1.2	1.5	0.4	-0.2	0.5	-0.0
Smoking status: Previous	0.2	0.4	1.4	0.5	0.2	-0.8	0.0	-0.0	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.1	-0.3	-1.2	-1.5	1.5	0.9	-1.2
Whole body fat-free mass	0.3	1.6	4.5	0.5	-2.1	-1.9	-0.3	0.1	-1.2
Leg fat-free mass (right)	0.5	2.7	6.2	1.4	-2.5	-2.0	-0.9	-0.7	-1.6
Arm fat percentage (left)	0.9	3.6	6.1	2.0	-2.5	-1.4	-1.8	-1.8	-1.7
Average weekly red wine intake	1.7	2.5	6.7	-1.8	2.6	0.9	1.3	1.5	0.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.4	1.2	-0.8	-0.6	-0.6	-0.5	-0.4
Mood swings	1.4	2.5	3.8	1.9	-1.9	-1.5	-0.9	-1.2	-1.7
Loneliness, isolation	0.4	0.6	1.3	-1.1	-0.2	0.2	1.0	0.9	-0.4
Long-standing illness, disability or infirmity	1.2	1.9	4.2	-0.1	-0.5	-1.8	-2.1	-1.5	-1.1
Ever had bowel cancer screening	0.6	0.7	2.8	-0.3	1.7	0.4	-0.5	-0.9	0.3
Diabetes diagnosed by doctor	0.8	1.3	5.4	-1.3	2.3	0.4	0.1	-0.1	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.6	0.8	-0.8	-1.5	-0.1	-0.5	-1.6
Friendships satisfaction	0.4	0.5	1.0	0.3	-0.8	-0.8	-0.3	-0.5	-1.0
Qualifications: nursing, teaching	2.7	4.2	6.4	-1.5	1.7	2.3	1.8	2.4	2.5
Commuting to job workplace: Walk	0.4	0.5	1.0	-0.9	1.0	0.6	-0.7	-0.4	0.2
Eye problems/disorders: Cataract	0.2	0.2	0.5	0.2	-0.3	-0.5	0.0	-0.7	-0.6
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.4	-0.9	1.6	1.8	1.1	0.8	1.7
Medication for cholesterol	0.3	0.5	0.7	0.7	0.9	-0.6	-0.5	-0.8	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.7	-1.1	1.1	0.9	-0.5	0.5	1.3
Back pain experienced in last month	0.6	0.9	2.0	0.8	0.2	0.1	-1.4	-1.2	1.0
Mineral and other dietary supplements	0.7	0.9	1.8	-1.3	0.1	0.5	1.4	1.3	0.3
Breast cancer (self-reported)	2.0	2.4	6.3	-1.2	0.5	2.5	1.6	1.0	1.7
Asthma (self-reported)	0.2	0.5	1.3	1.1	-1.1	-0.4	0.0	-0.0	-0.3
Osteoporosis (self-reported)	0.4	0.5	1.3	0.9	-0.0	-0.1	-1.1	-1.2	0.1
Osteoarthritis (self-reported)	0.4	0.5	2.6	1.6	-0.2	-0.7	-0.2	-0.3	0.0
Medication: Aspirin	0.3	0.4	0.8	-0.0	0.8	-0.9	0.3	0.3	-0.7
Medication: Gliclazide	0.3	0.4	1.2	-1.1	1.0	-0.1	0.0	0.3	-0.3
Illnesses of father: None of the above (group 1)	0.2	0.3	1.1	1.1	-0.1	0.5	0.5	0.0	0.3
Smoking status: Current	0.2	0.4	1.3	-0.3	1.1	0.1	-0.7	-0.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.4	-0.8	0.1	-1.0	1.2	0.1	-1.0
Whole body water mass	0.3	1.7	4.8	0.4	-2.2	-1.9	-0.2	0.2	-1.2
Leg predicted mass (right)	0.5	2.7	6.1	1.5	-2.5	-2.0	-1.0	-0.8	-1.6
Arm fat mass (left)	1.0	4.1	8.0	1.9	-2.8	-1.9	-1.8	-1.6	-2.0
Number of self-reported non-cancer illnesses	0.9	1.5	2.9	0.5	-0.9	-1.4	-1.7	-1.6	-0.7
Average weekly champagne plus white wine intake	0.4	0.5	1.0	-1.0	0.6	0.1	0.9	1.0	-0.1
Miserableness	0.2	0.3	0.7	-0.0	-0.8	0.5	0.8	0.5	0.4
Guilty feelings	3.6	5.4	7.3	2.6	-2.1	-2.4	-1.9	-2.7	-2.1
Wears glasses or contact lenses	1.1	1.2	2.7	1.2	0.6	-0.7	-1.6	-1.5	-0.0
Ever taken oral contraceptive pill	1.4	1.5	2.2	1.1	-1.4	-1.5	-0.9	-1.1	-1.3
Hearing aid user	0.3	0.4	1.4	-1.2	0.2	-0.5	0.5	0.3	-0.5
Mother’s age at death	0.3	0.4	1.3	1.1	0.3	0.9	0.1	-0.0	0.4
Financial situation satisfaction	2.7	3.3	4.9	1.6	-0.0	-2.1	-2.0	-1.9	-2.2
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.0	-0.9	-1.0	0.5	0.5	0.5	0.5
Commuting to job workplace: Public transport	0.3	0.3	0.7	0.7	0.5	-0.4	-0.8	-0.4	-0.3
Eye problems/disorders: Glaucoma	0.4	0.5	1.4	-0.0	1.2	0.6	0.7	0.1	0.7
Medication: Blood pressure	0.2	0.3	0.4	-0.7	-0.1	0.6	0.5	0.6	0.6
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.1	-0.4	1.0	0.3	-0.3	-0.1	0.4
Supplements: Fish oil (including cod liver oil)	1.4	1.9	4.5	1.7	-0.5	-0.5	-1.7	-2.1	-0.5
High cholesterol (Self-reported)	0.3	0.6	2.3	0.6	0.1	-0.3	-1.5	-0.9	0.4
Medication: Bendroflumethiazide	0.2	0.3	1.0	0.7	-0.1	-0.1	-1.0	-0.4	-0.3
Medication: Paracetamol	0.4	0.6	1.3	0.4	-1.1	-0.8	-1.0	-0.3	-0.4
Medication: Lisinopril	0.6	0.8	1.5	-1.2	1.1	0.5	0.1	1.2	0.6
Medication: Atorvastatin	0.3	0.4	1.5	0.4	-0.1	0.3	-0.7	-1.2	0.4
Illnesses of father: High blood pressure	1.1	1.4	2.7	-1.4	1.1	0.7	1.5	1.7	0.3
Alcohol drinker status: Never	0.3	0.4	0.7	0.8	0.1	-0.3	-0.7	-0.9	-0.6
Ever smoked	0.5	0.8	1.5	0.9	-0.1	-1.2	-1.1	-0.4	-1.1
Basal metabolic rate	0.5	2.7	6.8	0.9	-2.6	-2.2	-0.8	-0.4	-1.7
Leg fat percentage (left)	1.1	4.0	5.7	1.6	-1.8	-2.0	-2.3	-1.8	-2.4
Arm fat-free mass (left)	0.4	2.2	5.4	0.6	-2.3	-2.1	-0.8	-0.2	-1.6
Number of operations (self-reported)	0.5	0.7	1.4	0.6	-1.2	-0.5	-1.0	-1.2	0.1
Average weekly beer plus cider intake	1.4	2.0	3.9	2.0	0.2	-1.5	-1.3	-1.5	-1.3
Irritability	0.2	0.4	0.8	-0.7	0.7	0.9	0.6	0.1	0.2
Risk taking	2.8	4.1	8.3	-0.8	2.4	1.7	2.9	2.3	1.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	-0.1	0.5	0.7	0.2	-0.3	0.7
Fractured/broken bones in last 5 years	0.4	0.5	1.3	-0.2	-1.1	0.5	-0.1	-0.5	1.1
Age started oral contraceptive pill	0.2	0.3	0.9	0.9	-0.4	0.3	0.5	-0.3	0.3
Diastolic blood pressure, automated reading	0.3	0.9	2.9	-0.5	0.5	1.7	0.8	0.6	1.1
Ever depressed for a whole week	0.1	0.2	0.4	0.6	0.3	0.4	0.2	0.1	0.6
Unable to work because of sickness or disability	0.3	0.4	0.8	-0.6	-0.9	0.2	0.2	0.7	0.9
Commuting to job workplace: Cycle	0.6	0.8	1.5	1.0	-0.5	-1.2	-0.7	-0.7	-1.0
Myopia	3.2	4.7	8.4	-1.6	2.5	2.9	1.8	2.0	1.9
Vascular/heart problems diagnosed by doctor	0.5	1.5	2.6	1.6	-1.3	-1.3	-0.0	-0.6	-1.6
Cholesterol lowering medication	0.0	0.1	0.2	-0.3	-0.4	0.1	-0.3	-0.1	0.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	0.1	-0.0	-0.7	-0.3	-0.6	-0.7
Pain experienced in last month	0.4	0.7	1.2	-0.9	0.3	0.9	1.1	1.1	0.2
Supplements: Calcium	1.3	1.4	2.9	0.9	0.6	-1.1	-1.5	-1.7	-1.0
Basal cell carcinoma (self-reported)	1.3	1.6	2.9	1.0	-0.2	-1.6	-1.4	-1.7	-1.0
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.6	-0.3	-0.6	-0.7	0.5	0.2	-0.3
Deep venous thrombosis (DVT) (self-reported)	3.1	4.0	7.6	1.5	-2.7	-2.2	-1.7	-1.8	-1.7
Heart disease (siblings)	0.4	0.5	1.4	-0.4	1.2	-0.1	1.1	0.5	0.0
Alcohol drinker status: Previous	0.4	0.4	0.8	-0.4	0.3	0.8	0.9	0.5	0.9
Pack years of smoking	0.1	0.1	0.2	-0.0	0.4	0.4	-0.1	0.4	0.2
Impedance of whole body	0.2	0.9	2.2	1.2	0.8	0.1	-1.0	-1.5	-0.5
Leg fat mass (left)	1.4	5.3	7.1	1.9	-2.7	-2.4	-2.2	-1.9	-2.6
Arm predicted mass (left)	0.4	1.9	4.5	0.4	-2.1	-2.0	-0.7	-0.1	-1.5