Best TWAS P=2.64e-08 · Best GWAS P=4.16e-08 conditioned to 0.00373
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | TRIOBP | 0.13 | 0.14 | lasso | 7 | 0.14 | 3.9e-11 | -5.2 | 5.2 | 1.7e-07 | 0.61 | 0.04 | 0.96 | FALSE |
2 | GTEx | Artery Aorta | GCAT | 0.16 | 0.15 | lasso | 2 | 0.14 | 5.4e-08 | -5.2 | -5.2 | 1.8e-07 | -0.55 | 0.03 | 0.97 | FALSE |
3 | GTEx | Artery Aorta | C22orf23 | 0.10 | 0.01 | enet | 24 | 0.02 | 1.6e-02 | -4.2 | -5.1 | 2.7e-07 | -0.45 | 0.12 | 0.55 | FALSE |
4 | GTEx | Esophagus Gastroesophageal Junction | TRIOBP | 0.20 | -0.01 | lasso | 7 | 0.00 | 2.0e-01 | -4.7 | 5.3 | 1.1e-07 | 0.58 | 0.06 | 0.65 | FALSE |
5 | GTEx | Muscle Skeletal | GCAT | 0.13 | 0.10 | enet | 17 | 0.10 | 3.9e-10 | -5.2 | -5.3 | 1.4e-07 | -0.60 | 0.03 | 0.97 | FALSE |
6 | GTEx | Stomach | TRIOBP | 0.10 | 0.03 | lasso | 5 | 0.03 | 1.9e-02 | -4.7 | 5.1 | 3.1e-07 | 0.57 | 0.07 | 0.66 | FALSE |
7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ANKRD54 | 0.05 | 0.01 | blup | 31 | 0.02 | 1.3e-03 | -5.1 | 5.6 | 2.6e-08 | 0.55 | 0.01 | 0.89 | TRUE |
8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TRIOBP | 0.07 | 0.04 | blup | 67 | 0.03 | 2.1e-04 | -4.3 | 5.2 | 2.5e-07 | 0.67 | 0.23 | 0.72 | FALSE |
9 | The Cancer Genome Atlas | Thyroid Carcinoma | GCAT | 0.02 | 0.03 | blup | 29 | 0.03 | 1.4e-03 | -5.2 | -5.2 | 2.3e-07 | -0.58 | 0.02 | 0.74 | FALSE |
10 | The Cancer Genome Atlas | Thyroid Carcinoma | TRIOBP | 0.22 | 0.25 | enet | 37 | 0.27 | 6.9e-26 | -4.8 | 5.3 | 1.0e-07 | 0.72 | 0.13 | 0.87 | FALSE |