[Hub]/) : Traits : Intelligence (Savage-Jansen 2018) : ← →

chr21:39,849,553-41,419,624

Best TWAS P=1.67e-11 · Best GWAS P=6.56e-12 conditioned to 0.074

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	BRWD1	0.12	0.15	lasso	8	0.15	1.1e-17	5.9	-6.1	1.3e-09	-0.85	0.31	0.69	FALSE
2	GTEx	Adipose Subcutaneous	PSMG1	0.19	0.12	enet	26	0.13	4.1e-11	6.8	-5.8	6.7e-09	-0.90	0.03	0.97	FALSE
3	GTEx	Adipose Visceral Omentum	BRWD1-IT2	0.13	0.01	lasso	3	0.02	2.4e-02	6.6	6.6	3.0e-11	0.97	0.03	0.96	FALSE
4	GTEx	Artery Aorta	PSMG1	0.13	0.08	lasso	2	0.04	3.6e-03	5.5	-5.5	3.4e-08	-0.82	0.17	0.53	FALSE
5	GTEx	Artery Coronary	PSMG1	0.24	0.07	lasso	5	0.04	1.4e-02	5.5	-5.2	1.9e-07	-0.81	0.12	0.55	FALSE
6	GTEx	Brain Hypothalamus	PSMG1	0.46	0.20	lasso	5	0.16	1.5e-04	-3.7	-5.2	2.6e-07	-0.83	0.08	0.89	FALSE
7	GTEx	Breast Mammary Tissue	PSMG1	0.28	0.26	lasso	4	0.23	5.2e-12	6.5	-6.4	1.6e-10	-0.96	0.03	0.97	FALSE
8	GTEx	Breast Mammary Tissue (Male)	PSMG1	0.24	0.07	lasso	4	0.08	6.2e-03	6.6	-5.2	1.7e-07	-0.82	0.03	0.78	FALSE
9	GTEx	Breast Mammary Tissue (Female)	PSMG1	0.14	0.09	lasso	11	0.07	3.3e-03	6.5	-6.2	4.8e-10	-0.96	0.04	0.88	FALSE
10	GTEx	Colon Transverse	PSMG1	0.23	0.19	lasso	5	0.22	1.4e-10	-3.7	-5.5	4.3e-08	-0.86	0.09	0.91	FALSE
11	GTEx	Esophagus Mucosa	PSMG1	0.37	0.38	lasso	5	0.37	6.4e-26	6.5	-6.5	7.7e-11	-0.98	0.03	0.97	FALSE
12	GTEx	Esophagus Mucosa	HMGN1	0.11	0.08	lasso	4	0.07	2.6e-05	4.2	-5.4	7.5e-08	-0.81	0.10	0.89	FALSE
13	GTEx	Esophagus Mucosa	BRWD1-IT2	0.08	0.06	lasso	5	0.06	3.9e-05	5.5	5.6	2.3e-08	0.80	0.12	0.85	FALSE
14	GTEx	Esophagus Muscularis	PSMG1	0.15	0.10	lasso	4	0.07	3.9e-05	5.5	-5.5	3.5e-08	-0.82	0.14	0.85	FALSE
15	GTEx	Heart Atrial Appendage	PSMG1	0.14	0.12	lasso	2	0.10	2.2e-05	5.5	-5.5	3.4e-08	-0.82	0.07	0.92	FALSE
16	GTEx	Lung	PSMG1	0.12	0.13	lasso	5	0.12	3.4e-09	4.8	-5.4	6.2e-08	-0.82	0.12	0.88	FALSE
17	GTEx	Muscle Skeletal	PSMG1	0.13	0.16	enet	15	0.19	7.1e-18	4.7	-5.4	7.1e-08	-0.85	0.18	0.82	FALSE
18	GTEx	Nerve Tibial	PSMG1	0.27	0.24	lasso	5	0.21	1.6e-14	5.6	-5.4	6.0e-08	-0.83	0.74	0.26	FALSE
19	GTEx	Nerve Tibial	BRWD1	0.17	0.01	lasso	6	0.03	4.6e-03	-2.8	-5.3	1.3e-07	-0.55	0.10	0.73	FALSE
20	GTEx	Prostate	PSMG1	0.50	0.12	lasso	11	0.13	4.1e-04	5.9	-5.4	8.5e-08	-0.71	0.08	0.63	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	PSMG1	0.26	0.34	lasso	5	0.34	2.1e-19	6.5	-6.4	1.5e-10	-0.96	0.04	0.96	FALSE
22	GTEx	Skin Sun Exposed Lower leg	PSMG1	0.32	0.38	lasso	3	0.38	5.5e-33	6.5	-6.5	8.7e-11	-0.97	0.04	0.96	FALSE
23	GTEx	Skin Sun Exposed Lower leg	BRWD1	0.09	0.05	lasso	8	0.04	4.9e-04	6.5	-6.5	7.6e-11	-0.96	0.04	0.90	FALSE
24	GTEx	Stomach	PSMG1	0.23	0.02	lasso	8	0.05	1.8e-03	5.9	-5.5	3.5e-08	-0.68	0.11	0.76	FALSE
25	METSIM	Adipose	PSMG1	0.05	0.01	bslmm	638	0.02	3.6e-04	-4.3	-5.1	2.8e-07	-0.79	0.35	0.65	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	PSMG1	0.05	0.09	lasso	4	0.08	1.7e-16	6.6	-6.5	7.1e-11	-0.97	0.02	0.98	FALSE
27	The Cancer Genome Atlas	Colon Adenocarcinoma	HMGN1	0.06	0.03	blup	43	0.05	1.3e-03	4.2	-5.7	1.5e-08	-0.73	0.03	0.67	FALSE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMG1	0.09	0.05	lasso	2	0.03	6.5e-03	5.6	-5.5	3.0e-08	-0.81	0.02	0.56	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PSMG1	0.04	0.04	lasso	2	0.03	2.5e-04	5.5	-5.5	3.4e-08	-0.82	0.05	0.84	FALSE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMG1	0.08	0.06	blup	61	0.06	2.5e-04	5.6	-5.2	2.6e-07	-0.87	0.04	0.82	FALSE
31	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	HMGN1	0.12	0.12	enet	7	0.12	1.9e-06	5.9	-5.4	7.1e-08	-0.84	0.09	0.90	FALSE
32	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSMG1	0.07	0.07	blup	61	0.04	6.3e-03	4.7	-5.1	3.0e-07	-0.84	0.03	0.83	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PSMG1	0.11	0.10	blup	61	0.08	2.2e-04	6.5	-5.7	1.2e-08	-0.90	0.03	0.94	FALSE
34	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HMGN1	0.12	0.13	lasso	4	0.12	2.2e-05	6.6	-6.7	1.7e-11	-0.91	0.00	0.99	TRUE
35	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PSMG1	0.07	0.04	blup	61	0.06	1.7e-03	4.2	-5.9	4.8e-09	-0.93	0.02	0.90	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	HMGN1	0.27	0.06	enet	17	0.10	2.5e-10	4.2	-5.6	2.6e-08	-0.67	0.04	0.96	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMG1	0.07	0.10	lasso	3	0.10	1.8e-10	5.5	-5.3	9.1e-08	-0.84	0.29	0.71	FALSE
38	The Cancer Genome Atlas	Stomach Adenocarcinoma	BRWD1	0.04	0.02	blup	97	0.03	2.3e-03	3.1	-5.9	4.1e-09	-0.88	0.04	0.67	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	PSMG1	0.03	0.01	blup	61	0.02	9.1e-03	5.5	-5.7	1.5e-08	-0.92	0.02	0.75	FALSE