Best TWAS P=8.86e-14 · Best GWAS P=7.69e-16 conditioned to 2.81e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | SCMH1 | 0.09 | 0.01 | lasso | 3 | 0.00 | 1.4e-01 | 2.8 | 5.9 | 3.6e-09 | -0.56 | 0.12 | 0.69 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | FOXO6 | 0.27 | 0.16 | lasso | 6 | 0.32 | 1.0e-24 | -5.8 | -7.5 | 8.9e-14 | 0.41 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Esophagus Muscularis | SCMH1 | 0.18 | 0.03 | enet | 19 | 0.10 | 1.1e-06 | 2.9 | 5.4 | 5.7e-08 | -0.51 | 0.18 | 0.68 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | FOXO6 | 0.07 | 0.03 | enet | 14 | 0.05 | 1.5e-06 | -3.8 | -6.4 | 1.4e-10 | 0.35 | 0.87 | 0.07 | FALSE |