Best TWAS P=3.46e-10 · Best GWAS P=1.55e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | HYI | 0.38 | 0.09 | lasso | 9 | 0.07 | 1.6e-06 | -4.1 | -5.7 | 1.0e-08 | 0.33 | 0.96 | 0.03 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | ARTN | 0.13 | 0.08 | lasso | 3 | 0.07 | 2.4e-04 | -6.2 | -5.5 | 3.0e-08 | 0.92 | 0.03 | 0.92 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | ST3GAL3 | 0.03 | -0.01 | lasso | 2 | 0.01 | 1.6e-01 | -6.3 | -6.3 | 3.5e-10 | 0.95 | 0.03 | 0.36 | TRUE |
| 4 | GTEx | Heart Left Ventricle | MED8 | 0.08 | 0.01 | lasso | 3 | 0.01 | 1.2e-01 | 5.4 | -5.8 | 8.2e-09 | 0.06 | 0.19 | 0.07 | FALSE |
| 5 | GTEx | Lung | HYI | 0.18 | 0.04 | enet | 22 | 0.06 | 1.8e-05 | 4.5 | -6.0 | 2.2e-09 | 0.08 | 0.97 | 0.01 | TRUE |
| 6 | GTEx | Muscle Skeletal | B4GALT2 | 0.04 | 0.05 | lasso | 2 | 0.03 | 6.4e-04 | -6.2 | 6.0 | 2.5e-09 | -0.95 | 0.02 | 0.92 | FALSE |
| 7 | GTEx | Stomach | HYI | 0.16 | 0.06 | lasso | 6 | 0.07 | 4.1e-04 | -3.6 | -5.6 | 2.6e-08 | 0.10 | 0.39 | 0.11 | FALSE |
| 8 | METSIM | Adipose | ARTN | 0.05 | 0.04 | bslmm | 412 | 0.03 | 1.3e-05 | -2.7 | -5.2 | 2.6e-07 | 0.64 | 0.83 | 0.16 | FALSE |