Best TWAS P=1.63e-10 · Best GWAS P=4.14e-11 conditioned to 0.00226
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | ZMIZ2 | 0.12 | 0.09 | lasso | 4 | 0.06 | 2.3e-05 | 5.9 | 5.2 | 2.5e-07 | 0.81 | 0.05 | 0.94 | FALSE |
| 2 | GTEx | Muscle Skeletal | OGDH | 0.09 | 0.02 | enet | 12 | 0.03 | 5.4e-04 | -4.2 | -5.6 | 2.7e-08 | -0.43 | 0.05 | 0.92 | TRUE |
| 3 | GTEx | Nerve Tibial | ZMIZ2 | 0.12 | 0.06 | lasso | 5 | 0.06 | 5.1e-05 | 6.6 | -6.0 | 1.9e-09 | -0.57 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Thyroid | H2AFV | 0.15 | 0.04 | lasso | 6 | 0.08 | 1.8e-06 | -4.8 | -6.4 | 1.6e-10 | -0.24 | 0.34 | 0.22 | TRUE |
| 5 | NTR | Blood | ZMIZ2 | 0.08 | 0.06 | enet | 17 | 0.06 | 1.5e-18 | -5.7 | 5.5 | 2.9e-08 | 0.38 | 0.14 | 0.86 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | ZMIZ2 | 0.10 | 0.06 | enet | 15 | 0.07 | 1.3e-09 | -5.4 | -5.1 | 2.9e-07 | -0.25 | 0.72 | 0.28 | FALSE |