Hub : Genes

H2AFV

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1410 0.0360 7.4e-09 0.076 0.079 0.067 0.084 0.085 1.6e-09 6.7e-10 1.4e-08 1.9e-10 1.8e-10
2 GTEx Artery Aorta 0.1020 0.0470 5.5e-03 0.080 NA 0.027 NA 0.065 3.4e-05 NA 1.3e-02 NA 1.9e-04
3 GTEx Testis 0.2190 0.0770 1.6e-03 0.058 NA 0.008 NA 0.049 1.4e-03 NA 1.4e-01 NA 3.2e-03
4 GTEx Thyroid 0.1470 0.0550 1.2e-03 0.036 NA 0.037 NA 0.076 8.5e-04 NA 8.0e-04 NA 1.8e-06
5 TCGA Breast Invasive Carcinoma 0.0459 0.0243 1.6e-07 0.038 0.037 0.033 NA 0.036 2.1e-08 4.5e-08 1.7e-07 NA 4.7e-08
6 TCGA Prostate Adenocarcinoma 0.0818 0.0503 9.1e-05 0.034 0.050 0.055 NA 0.046 1.6e-04 6.2e-06 1.9e-06 NA 1.3e-05
7 TCGA Thyroid Carcinoma 0.1450 0.0620 1.4e-12 0.141 0.136 0.132 NA 0.141 1.3e-13 4.0e-13 7.7e-13 NA 1.3e-13

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.3 0.5 2.2 -0.1 0.7 -0.2 1.5 0.8 0.2 0.6
Bipolar Disorder or Schizophrenia 0.5 1.2 2.0 0.1 1.4 -0.5 1.1 1.3 1.4 1.2
Depressed Affect (Nagel 2018) 0.3 0.6 1.1 -0.4 0.9 0.0 1.1 1.1 0.8 0.8
Depression (Nagel 2018) 0.8 1.3 3.8 1.2 0.7 -1.0 2.0 0.8 1.0 0.7
Intelligence (Savage-Jansen 2018) 6.8 20.9 40.8 -4.1 -4.8 4.7 -6.4 -3.5 -2.8 -4.8
Neuroticism (Nagel 2018) 0.5 1.1 2.0 -0.1 1.3 -0.3 1.1 1.4 1.0 1.2
Schizophrenia (2018) 0.4 0.9 2.3 0.3 1.2 -0.6 0.2 1.0 1.5 1.0
Schizophrenia vs Biploar Disorder 0.3 0.4 0.7 -0.3 0.8 0.1 -0.6 0.7 0.9 0.7
Worry (Nagel 2018) 0.1 0.2 0.6 -0.8 -0.2 0.5 0.0 0.0 -0.7 -0.3
Alzheimer’s Disease (in mother) 0.9 1.0 3.2 1.8 0.5 -1.5 -0.2 0.5 0.8 0.8
Alzheimer’s Disease (in father) 0.5 0.5 3.0 -1.7 0.4 0.5 -0.2 0.3 0.1 0.1
Alzheimer’s Disease (including proxy) 0.1 0.2 0.3 -0.0 0.5 -0.6 -0.1 0.4 0.5 0.5
Crohns Disease (2017) 0.5 1.1 3.0 -1.7 -0.4 1.4 -0.8 -0.5 -1.2 -0.6
Irritable Bowel Disease (IBD) 1.3 3.1 4.6 -2.2 -1.5 2.1 -1.9 -1.1 -1.7 -1.6
Ulcerative Colitis (UC) 1.1 2.1 3.5 -1.2 -1.7 1.5 -1.9 -0.9 -1.1 -1.7
Major Depression (MDD) 2.5 3.0 6.4 -2.5 -1.6 2.1 -1.3 -1.2 -1.2 -1.8
Reaction Time 1.0 1.9 4.4 0.3 2.0 -0.9 2.1 0.7 -0.7 1.7
Verbal and Numeric Reasoning (VNR) 3.9 9.4 18.9 -2.8 -3.1 3.3 -4.3 -2.1 -2.0 -3.2
Breast Cancer 0.9 2.1 4.4 -0.2 2.1 -0.9 2.1 1.0 0.6 1.9
Ovarian Cancer 0.6 0.7 2.1 0.3 1.4 -0.8 -0.2 0.8 0.1 1.2
Prostate Cancer 0.2 0.3 1.2 -1.1 0.2 0.6 -0.0 0.2 -0.4 -0.0
Age at First Birth 2.7 3.9 8.4 -2.8 -1.7 2.9 -1.7 -0.7 -0.8 -2.1
Bipolar Disorder (2011) 1.5 1.4 8.5 1.2 0.0 0.0 2.9 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 1.8 0.4 -1.3 0.1 0.2 -1.3 -0.4 -1.1
Coronary Artery Disease (CAD) 4.6 5.5 7.7 -2.8 -2.5 2.3 -1.5 -2.3 -2.4 -2.5
Crohns Disease (2012) 0.1 0.1 0.4 -0.4 0.6 0.1 0.2 0.2 0.1 0.5
Mean Putamen Volume 0.2 0.2 0.9 -0.2 0.1 0.3 1.0 0.8 0.2 0.1
Fasting Glucose 0.4 0.5 1.5 1.2 0.4 -0.8 0.6 0.3 0.3 0.6
HbA1C 0.2 0.2 0.6 0.5 0.1 -0.4 0.8 -0.5 -0.4 0.1
HDL Cholesterol 0.3 0.5 1.2 -1.1 0.8 0.8 0.6 0.6 0.1 0.4
LDL Cholesterol 0.7 1.2 1.8 -0.7 -1.4 0.6 -1.2 -1.2 -1.0 -1.2
Lupus 0.3 0.5 1.6 0.1 -0.9 0.2 -0.5 -1.3 -0.4 -0.8
Neuroticism (2016) 0.8 1.2 2.4 -0.6 1.2 0.4 1.6 1.3 1.1 1.1
Primary Biliary Cirrhosis 6.0 8.5 11.9 -2.6 -3.1 2.6 -2.5 -3.5 -3.0 -3.1
Rheumatoid Arthritis 0.5 0.7 1.3 0.9 0.9 -1.1 1.1 -0.0 -0.1 0.9
Schizophrenia (2014) 0.7 1.6 3.1 -0.1 1.7 -0.4 0.9 1.6 1.8 1.4
Triglycerides 0.1 0.1 0.3 -0.1 -0.5 -0.1 0.3 -0.3 -0.4 -0.4
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.8 0.7 1.2 -1.2 0.4 0.3 0.5 1.4
Ulcerative Colitis 1.2 1.7 2.3 -1.3 -1.5 1.5 -1.0 -1.1 -1.1 -1.5
Blood Eosinophil Count 1.2 9.3 22.2 4.7 2.2 -3.7 2.5 2.2 2.4 2.8
Blood Platelet Count 19.6 227.3 309.8 17.6 14.7 -17.4 13.9 12.6 12.8 15.7
Blood Red Count 19.0 183.3 249.6 15.5 13.1 -15.8 12.0 11.2 12.6 13.9
Blood White Count 5.0 36.8 65.1 8.1 5.2 -7.3 6.1 4.1 4.9 5.8
Heel T-Score 0.2 1.6 3.4 1.7 0.9 -1.9 1.4 0.3 0.9 1.1
BMI 2.1 12.2 23.1 4.8 1.9 -4.4 4.5 2.1 3.0 2.3
Height 1.0 19.8 40.1 -3.3 -5.2 3.6 -6.3 -3.7 -3.3 -4.9
Waist Hip Ratio (WHR) 0.1 0.5 2.1 -1.4 0.1 1.0 0.3 0.3 -0.2 -0.1
Systolic Blood Pressure 0.1 0.3 0.7 0.6 0.0 -0.6 0.8 -0.6 0.7 0.2
Smoking Status 0.1 0.3 0.9 1.0 -0.4 -0.4 0.7 -0.4 -0.0 -0.1
Allergy or Eczema 0.7 1.8 7.0 -0.8 -0.5 1.1 -1.1 -1.3 -2.6 -0.6
Cardiovascular Disease 0.1 0.4 1.4 1.0 0.0 -0.7 1.2 -0.5 0.1 0.2
Hypothyroidism (self reported) 0.6 1.3 3.0 -0.1 -1.7 0.6 -1.5 -0.8 -0.5 -1.6
Respiratory disease 0.7 1.5 3.9 -0.6 -1.3 0.7 -0.3 -1.5 -2.0 -1.3
Type 2 Diabetes (T2D) (2018) 3.0 5.6 10.0 2.5 2.5 -2.0 3.2 2.1 1.4 2.5
Lung FEV1/FVC ratio 0.3 1.6 3.0 1.7 0.7 -1.4 0.8 1.1 1.7 0.9
Lung FVC 0.2 1.0 2.1 0.6 1.2 -0.9 1.4 0.3 0.6 1.1
Neuroticism 0.8 1.9 4.9 -0.0 1.4 -0.5 2.2 1.6 1.4 1.4
Chronotype (morning person) 0.6 1.4 2.4 0.3 1.5 -0.9 1.4 1.3 0.6 1.4
Hair Pigment 0.0 0.6 1.4 0.5 -0.9 -0.6 -0.0 -1.2 -0.9 -0.6
Tanning 0.2 2.3 5.9 0.4 2.4 -1.1 0.6 1.8 0.6 2.2
Hand grip strength (left) 0.1 0.3 1.0 -0.4 -0.0 0.7 -1.0 -0.1 0.7 -0.1
Number of treatments/medications taken 0.2 0.3 1.6 0.1 0.4 -0.1 1.3 0.0 -0.2 0.4
Average weekly spirits intake 0.3 0.3 0.9 0.7 -0.0 -0.6 -0.7 0.2 0.9 0.1
Sensitivity / hurt feelings 0.5 0.9 1.3 0.9 1.1 -1.0 0.8 0.9 0.8 1.1
Frequency of depressed mood in last 2 weeks 0.2 0.2 1.0 0.2 -0.3 0.3 1.0 0.2 0.6 -0.3
Hearing difficulty/problems: Yes 0.4 0.6 1.3 0.4 0.4 -0.7 -0.8 1.1 1.1 0.5
Relative age of first facial hair 2.1 4.4 5.8 -2.2 -2.1 2.0 -2.4 -1.9 -1.9 -2.0
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 3.2 -0.9 -1.1 0.9 0.2 -1.4 -1.8 -1.1
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.8 -0.7 0.8 0.1 1.0 1.4 0.8 0.7
Ever had hysterectomy (womb removed) 0.5 0.6 1.3 0.1 -1.1 0.4 -0.5 -0.8 -0.9 -1.0
Systolic blood pressure, automated reading 0.6 1.8 4.7 2.2 0.7 -1.7 1.4 0.2 1.2 0.9
Eye problems/disorders: Diabetes related eye disease 1.4 1.6 3.3 -0.0 1.6 -0.5 1.8 1.8 0.2 1.3
Angina 0.1 0.2 1.1 -0.3 0.3 0.0 1.1 0.2 0.0 0.2
Medication for hormone replacement therapy 0.8 0.9 1.4 -0.8 1.2 0.2 1.1 1.0 0.9 0.9
Vitamin and mineral supplements 0.1 0.1 0.5 0.1 -0.1 0.1 0.1 -0.4 -0.7 -0.0
Supplements: Zinc 0.1 0.1 0.3 -0.1 0.4 -0.2 -0.4 0.4 0.5 0.3
Medication: Co-codamol 1.4 1.6 3.9 0.7 1.5 -1.1 2.0 1.0 0.7 1.4
Medication: Metformin 3.0 4.2 8.2 1.6 2.1 -1.6 2.9 2.1 1.8 2.1
Diabetes (father) 0.3 0.4 0.8 -0.4 -0.6 0.7 -0.4 -0.9 -0.8 -0.6
Diabetes (mother) 1.3 1.6 3.2 -0.3 1.5 -0.1 1.8 1.8 0.8 1.4
Severe depression (siblings) 1.3 1.5 2.9 0.8 1.7 -0.6 1.5 1.3 -0.0 1.6
Pack years adult smoking proportion 0.9 1.4 2.8 1.5 0.8 -1.7 0.9 0.7 1.3 1.0
Impedance of leg (right) 0.5 2.4 5.8 -2.4 -0.4 1.5 -2.4 -0.6 -1.4 -0.7
Leg fat-free mass (left) 0.7 3.7 12.8 3.6 0.3 -2.7 1.5 0.8 1.4 0.9
Trunk fat percentage 0.7 2.6 8.6 2.9 0.2 -2.5 1.4 0.3 1.1 0.6
Hand grip strength (right) 0.2 0.5 2.0 0.3 0.6 -0.2 -0.3 0.7 1.4 0.7
Townsend deprivation index at recruitment 1.9 2.7 3.4 1.1 1.8 -1.6 1.9 1.5 1.6 1.8
Current tobacco smoking 0.1 0.2 0.6 0.2 -0.8 -0.2 0.2 -0.7 -0.4 -0.6
Average weekly fortified wine intake 0.7 0.8 2.3 0.7 -0.7 0.1 -1.3 -0.6 -1.5 -0.5
Maternal smoking around birth 0.8 1.2 2.2 0.5 1.0 -0.8 1.5 1.4 1.1 1.0
Fed-up feelings 1.6 2.8 4.9 0.9 1.8 -1.4 2.2 1.7 1.7 1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 4.8 6.4 13.0 2.5 2.2 -2.6 3.6 2.0 2.2 2.3
Relative age voice broke 0.6 0.9 1.6 -0.9 -0.9 0.9 -1.2 -0.5 -1.1 -0.8
Taking other prescription medications 0.2 0.3 1.0 -0.2 0.6 0.1 1.0 0.5 -0.1 0.4
Age when periods started (menarche) 0.1 0.2 0.7 0.3 -0.5 0.4 -0.8 -0.2 -0.4 -0.3
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.9 0.8 0.5 -0.7 0.5 0.6 1.4 0.6
Heel bone mineral density (BMD) T-score, automated (left) 2.4 5.5 8.4 1.5 2.6 -2.2 2.9 2.1 2.4 2.5
Tinnitus: Yes, but not now, but have in the past 1.9 2.1 5.6 2.4 1.1 -2.1 0.9 0.5 0.5 1.4
Qualifications: CSEs or equivalent 2.0 2.7 4.3 1.8 1.0 -2.1 2.1 1.1 1.8 1.1
Serious illness, injury or assault to yourself 1.5 1.9 3.5 1.2 1.3 -1.3 1.9 1.6 0.8 1.2
High blood pressure 0.0 0.1 0.3 0.5 0.1 -0.3 0.4 -0.5 0.0 0.3
Hayfever, allergic rhinitis or eczema 0.9 2.0 5.9 -0.8 -0.6 0.9 -1.9 -1.4 -2.4 -0.6
Multivitamins +/- minerals 0.3 0.4 1.1 -0.3 0.2 -0.0 -0.5 1.0 1.1 0.1
Stomach or abdominal pain in last month 0.1 0.2 0.5 0.2 -0.0 -0.4 -0.2 -0.5 -0.7 0.1
Supplements: Glucosamine 0.6 0.8 3.1 -1.8 -0.0 1.4 -0.3 0.4 0.4 -0.2
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 2.0 -0.3 -0.5 0.5 0.4 -1.1 -1.4 -0.4
Medication: Atenolol 0.2 0.2 1.1 -0.5 0.0 0.3 1.0 -0.4 -0.1 0.0
Medication: Levothyroxine sodium 0.1 0.2 0.8 0.2 -0.3 -0.2 -0.9 0.2 0.5 -0.3
Sitting height 0.4 2.7 10.2 -0.4 -1.4 0.4 -3.2 -1.5 -1.5 -1.2
Chronic bronchitis/emphysema (father) 1.1 1.3 3.6 1.9 0.7 -1.3 1.1 0.1 0.9 0.9
High blood pressure (mother) 1.4 2.0 4.4 0.8 1.3 -1.1 2.1 1.0 1.7 1.4
Body mass index (BMI) 3.0 12.8 25.6 5.1 2.2 -4.6 4.2 1.9 3.1 2.6
Impedance of leg (left) 1.0 4.7 11.7 -3.4 -0.9 2.4 -3.0 -1.0 -1.6 -1.3
Leg predicted mass (left) 0.7 3.6 12.8 3.6 0.3 -2.7 1.6 0.7 1.3 0.8
Trunk fat mass 0.8 3.6 11.8 3.4 0.3 -2.9 1.5 0.5 1.4 0.8
Waist circumference 0.8 2.9 7.7 2.8 0.6 -2.4 2.0 0.7 1.2 0.9
Number of incorrect matches in round 0.5 0.8 2.4 -1.5 0.7 1.1 -0.2 1.0 0.6 0.3
Past tobacco smoking 0.2 0.3 0.8 0.8 0.6 -0.9 -0.2 0.2 0.4 0.6
Alcohol usually taken with meals 0.7 1.1 3.9 -2.0 -0.3 1.5 -0.6 0.6 0.4 -0.5
Nervous feelings 1.6 3.0 5.1 -2.3 -1.9 2.2 -1.2 -1.0 -1.1 -1.9
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.1 0.3 0.0 0.1 0.1 0.4 -0.1 -0.6 0.2
Hearing difficulty/problems with background noise 1.6 2.6 10.3 -1.7 -0.9 1.7 -3.2 -0.2 0.3 -1.0
Hair/balding pattern: Pattern 2 0.9 1.1 1.9 1.1 0.8 -1.0 1.4 0.9 1.3 0.8
Had menopause 1.0 1.2 3.0 -1.7 -1.0 1.6 -0.9 -0.4 0.1 -1.1
Had other major operations 0.4 0.4 1.7 -1.3 -0.1 1.0 -0.4 0.1 -0.3 -0.2
Forced vital capacity (FVC) 0.2 0.9 1.9 1.4 0.9 -1.3 -0.3 0.7 0.4 1.0
Heel bone mineral density (BMD) T-score, automated (right) 1.5 3.5 5.7 0.5 2.2 -1.4 2.4 1.9 2.0 2.0
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.3 -0.1 -0.5 0.2 -0.6 0.2 0.4 -0.4
Qualifications: None of the above 1.0 2.2 10.4 1.5 0.1 -1.4 3.2 -0.6 -0.2 0.3
Financial difficulties in last 2 years 0.7 0.9 2.6 -0.1 1.0 -0.3 1.6 1.0 1.0 0.8
Mouth/teeth dental problems 7.1 10.8 13.5 -2.4 -3.6 3.4 -2.8 -3.4 -3.7 -3.5
Heart attack 0.5 0.7 1.8 -0.5 -0.6 0.5 -0.3 -1.2 -1.4 -0.7
Allergy 0.5 1.1 4.7 0.1 0.4 -0.5 1.0 1.1 2.2 0.4
Pain all over the body in last month 0.1 0.1 0.2 0.3 -0.4 -0.4 -0.3 -0.4 -0.2 -0.3
Diabetes (self-reported) 3.8 5.9 7.8 2.4 2.8 -2.1 2.8 2.2 1.8 2.8
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 1.2 -0.0 0.2 0.1 -1.1 0.4 -0.6 0.3
Medication: Ramipril 0.4 0.6 3.6 0.5 0.0 -0.1 -1.9 -0.3 0.2 0.2
Medication: Simvastatin 0.3 0.4 0.9 0.8 -0.5 -0.4 0.4 -0.9 -0.8 -0.3
Fluid intelligence score 5.1 10.6 23.0 -3.2 -3.1 3.7 -4.8 -1.9 -2.0 -3.2
Illnesses of siblings 0.5 0.7 1.6 -1.2 -0.5 1.2 -0.9 0.1 -0.6 -0.7
Neuroticism score 0.7 1.4 3.2 0.5 1.1 -0.8 1.8 1.4 1.2 1.1
Weight 0.9 4.6 14.1 3.8 0.5 -3.2 1.9 0.8 1.7 1.0
Impedance of arm (right) 0.7 3.2 8.0 -2.2 -1.0 2.0 -2.8 -0.5 -1.7 -1.2
Arm fat percentage (right) 1.6 6.2 15.1 3.9 1.2 -3.4 2.7 1.3 1.9 1.6
Trunk fat-free mass 0.2 1.4 5.8 2.4 -0.3 -1.9 0.4 0.2 0.6 0.2
Hip circumference 0.4 1.8 7.8 2.8 -0.3 -2.0 0.4 -0.1 0.7 0.1
Time employed in main current job 0.7 0.8 1.9 0.7 -1.1 0.2 -0.4 -1.4 -0.8 -0.9
Alcohol intake versus 10 years previously 0.6 0.8 2.1 1.2 0.7 -1.4 0.3 0.6 0.8 0.8
Father’s age at death 0.3 0.4 1.0 -1.0 -0.3 0.8 -0.6 -0.1 -0.5 -0.4
Worrier / anxious feelings 0.1 0.1 0.3 0.5 0.2 -0.4 0.1 0.3 -0.1 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.6 -0.8 -0.6 0.4 0.5 -0.4 -0.4 -0.7
Falls in the last year 0.3 0.4 1.0 0.9 0.0 -1.0 0.2 -0.6 0.6 0.1
Hair/balding pattern: Pattern 3 0.7 1.0 3.5 -1.9 -0.4 1.3 -0.5 -0.6 -0.6 -0.5
Number of live births 0.7 1.0 1.9 -1.4 -0.9 1.2 -0.5 -1.0 -0.7 -1.0
Forced expiratory volume in 1-second (FEV1) 0.5 1.8 3.8 2.0 1.2 -1.8 0.0 1.0 0.9 1.4
Pulse rate 1.6 2.7 6.9 -2.6 -1.0 2.0 -0.7 -1.4 -1.7 -1.4
Happiness 0.6 0.7 2.0 -1.4 -0.6 1.4 -0.0 -0.0 0.1 -0.7
Noisy workplace 12.9 15.9 25.5 3.5 4.0 -4.0 5.0 3.7 3.5 4.0
Qualifications: A levels/AS levels or equivalent 1.4 3.2 5.9 -2.4 -1.4 2.4 -1.7 -0.8 -1.6 -1.6
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.3 0.9 0.8 -0.9 0.5 1.0 1.1 0.8
Mouth/teeth dental problems: Dentures 0.6 1.0 2.1 0.9 0.8 -1.4 1.0 0.5 1.2 0.9
Asthma 0.7 1.4 3.0 -0.1 -1.7 0.5 -0.6 -1.5 -1.2 -1.6
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 5.1 1.2 1.0 -1.4 2.3 0.8 1.1 1.0
Medication: Cholesterol lowering 0.1 0.1 0.6 0.0 -0.3 -0.0 -0.1 -0.8 -0.2 -0.3
Depression (self-reported) 1.3 1.6 2.9 1.1 0.9 -1.1 1.7 1.5 1.4 0.9
Medication: Lansoprazole 0.4 0.5 1.2 1.1 0.7 -0.8 0.7 0.2 0.5 0.7
Prospective memory result 0.2 0.2 1.5 0.2 0.2 -0.3 1.2 -0.2 0.0 0.2
Lung cancer (father) 0.4 0.4 0.9 0.2 0.6 -0.6 -0.9 0.4 0.9 0.6
Illnesses of mother 1.7 2.1 6.9 -0.9 -1.2 0.9 -2.6 -0.9 -1.3 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 2.5 1.6 1.3 -1.3 0.1 1.2 1.3 1.4
Pulse wave Arterial Stiffness index 0.5 0.6 1.0 -0.9 -0.7 1.0 -0.8 -0.0 -0.6 -0.8
Impedance of arm (left) 1.3 6.0 12.3 -2.7 -1.8 2.7 -3.5 -1.4 -2.5 -2.0
Arm fat mass (right) 1.4 5.9 16.2 4.0 0.8 -3.5 2.4 1.0 2.0 1.3
Trunk predicted mass 0.3 1.5 6.0 2.4 -0.2 -1.9 0.5 0.2 0.7 0.3
Standing height 0.9 9.0 21.6 -2.1 -3.2 2.5 -4.7 -2.1 -2.5 -3.0
Length of working week for main job 1.5 1.7 4.7 2.2 0.6 -1.9 1.1 0.5 1.1 0.8
Exposure to tobacco smoke at home 0.4 0.5 1.2 -1.1 -0.2 1.0 -0.8 -0.5 -0.4 -0.4
Breastfed as a baby 0.2 0.3 0.8 0.5 0.6 -0.2 0.1 0.9 0.5 0.5
Tense / ‘highly strung’ 0.4 0.7 2.9 -0.4 0.5 -0.4 0.4 1.1 1.7 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.0 -0.3 0.2 0.1 -0.3 1.0 0.9 0.1
Hair/balding pattern: Pattern 4 0.1 0.4 1.0 0.7 0.4 -0.4 0.2 0.7 1.0 0.5
Birth weight of first child 0.9 1.7 3.5 -1.1 -1.7 0.9 -1.9 -0.8 -0.7 -1.6
Peak expiratory flow (PEF) 0.9 2.2 6.5 2.5 0.8 -2.2 1.0 0.9 0.8 1.0
Pulse wave reflection index 0.3 0.3 1.3 -0.0 -0.0 0.2 -0.7 1.1 0.8 -0.1
Ever highly irritable/argumentative for 2 days 1.2 1.4 4.0 2.0 0.4 -1.5 0.9 0.7 1.3 0.6
Loud music exposure frequency 1.6 1.7 2.5 1.6 1.4 -1.5 1.4 0.9 0.6 1.5
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 2.9 -0.4 -0.4 0.5 -1.7 -0.2 -0.4 -0.5
Mouth/teeth dental problems: Bleeding gums 1.8 2.4 4.2 0.4 2.0 -1.1 1.4 1.7 1.6 1.9
Blood clot in the leg (DVT) 0.3 0.3 1.0 1.0 0.4 -0.7 0.3 0.6 0.0 0.4
Medication: Paracetamol 0.9 1.5 3.8 0.5 1.4 -1.2 2.0 1.0 0.7 1.4
Headache pain in last month 0.1 0.2 0.5 0.6 0.6 -0.7 0.3 0.2 -0.3 0.4
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.9 -0.6 0.2 0.4 -0.2 0.9 0.4 0.1
Glaucoma (self-reported) 2.8 3.3 7.3 0.8 2.2 -1.4 1.5 2.7 1.4 2.1
Gout (self-reported) 0.3 0.4 1.0 1.0 0.4 -0.8 0.7 0.2 -0.3 0.5
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 1.6 0.2 -1.3 0.3 -1.2 -0.6 -0.2 -1.1
Medication: Amlodipine 1.3 1.8 2.7 0.9 1.5 -1.1 1.7 1.4 1.3 1.4
Medication: Ventolin 100micrograms inhaler 0.7 0.9 1.3 -1.1 -0.8 1.0 -1.1 -0.5 -0.8 -0.9
Birth weight 0.3 0.5 2.3 -1.5 -0.1 1.2 0.1 -0.0 0.0 -0.3
Chronic bronchitis/emphysema (mother) 0.3 0.3 1.4 0.1 0.0 0.3 1.2 0.1 -0.7 0.0
High blood pressure (siblings) 0.4 0.5 0.9 -0.9 -0.6 0.8 -0.3 -1.0 -0.7 -0.6
Forced vital capacity (FVC), Best measure 0.1 0.2 0.8 0.6 0.3 -0.2 -0.9 0.2 0.3 0.4
Body fat percentage 1.2 4.7 12.0 3.5 0.9 -3.1 2.3 0.9 1.7 1.3
Leg fat percentage (right) 3.1 11.3 21.3 4.6 2.4 -4.5 3.7 2.0 2.7 2.7
Arm fat-free mass (right) 0.6 2.9 8.7 3.0 0.2 -2.5 1.5 0.5 1.4 0.6
Exposure to tobacco smoke outside home 4.4 5.9 9.5 2.1 2.5 -2.6 2.0 1.7 3.1 2.6
Comparative body size at age 10 0.5 1.4 5.4 2.3 0.1 -1.9 -0.1 0.0 0.8 0.3
Number of full brothers 2.0 2.5 5.0 0.8 1.5 -1.1 1.8 1.6 2.2 1.5
Worry too long after embarrassment 4.8 8.0 11.4 1.7 3.3 -2.3 2.5 3.4 2.9 3.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.8 -0.6 -0.7 0.9 -0.5 -0.3 0.0 -0.8
Wheeze or whistling in the chest in last year 2.5 4.4 6.3 1.9 2.1 -2.1 2.5 1.9 1.8 2.2
Number of children fathered 1.8 2.0 2.9 1.0 1.6 -1.3 1.7 1.7 0.8 1.6
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 0.9 0.9 0.7 -0.7 0.4 0.6 0.8 0.8
Age at first live birth 1.0 1.8 2.6 -1.4 -1.5 1.6 -1.3 -0.9 -1.2 -1.5
Pulse wave peak to peak time 0.5 0.6 1.1 1.0 0.7 -1.0 0.8 0.1 0.6 0.9
Health satisfaction 0.1 0.1 0.6 -0.2 0.1 0.2 -0.0 -0.1 -0.8 0.1
Shortness of breath walking on level ground 0.1 0.1 0.3 0.1 0.4 0.1 0.6 -0.0 -0.4 0.3
Qualifications: College or University degree 4.5 14.0 23.9 -3.9 -3.3 4.2 -4.9 -2.5 -3.5 -3.5
Eye problems/disorders: None of the above 1.0 1.1 2.1 -0.8 -1.3 0.9 -1.5 -1.0 -0.3 -1.2
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.6 -0.5 0.8 -0.3 0.4 0.5 -0.5 0.6
Emphysema/chronic bronchitis 0.3 0.3 1.2 0.5 0.5 -0.6 1.1 0.2 -0.1 0.5
Medication for pain relief, constipation, heartburn 2.5 4.3 10.0 -1.4 -2.2 1.9 -3.2 -1.8 -1.3 -2.2
Neck or shoulder pain in last month 0.3 0.5 1.2 0.2 1.1 -0.4 0.6 0.4 0.4 1.0
Medication: Blood pressure 0.2 0.4 0.8 0.8 0.8 -0.8 0.3 0.1 0.1 0.9
Angina (self-reported) 0.1 0.1 0.8 -0.3 0.1 0.1 0.9 -0.1 -0.3 0.0
Migraine (self-reported) 0.1 0.1 0.5 -0.7 0.4 0.3 0.2 0.1 -0.1 0.2
Medication: Ibuprofen 1.6 2.0 4.1 1.7 1.1 -1.6 2.0 0.8 1.0 1.1
Medication: Allopurinol 0.8 1.1 3.0 1.7 0.8 -1.6 0.4 0.5 0.4 0.8
Medication: Omeprazole 0.7 0.9 2.0 -0.7 -0.9 0.8 -0.6 -0.9 -1.4 -0.9
Medication: Seretide 50 evohaler 0.0 0.0 0.1 -0.1 -0.2 -0.2 0.0 0.3 0.0 -0.2
Mean time to correctly identify matches 0.8 1.5 3.9 0.2 1.8 -0.6 2.0 0.2 -0.8 1.5
Heart disease (mother) 1.1 1.3 5.5 0.7 1.1 -0.6 2.4 0.6 0.4 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 0.9 -0.2 -0.3 0.6 -0.5 -0.7 -1.0 -0.4
Whole body fat mass 1.1 4.5 13.1 3.6 0.5 -3.2 1.9 0.7 1.6 1.0
Leg fat mass (right) 2.3 8.8 19.7 4.4 1.7 -4.1 3.1 1.5 2.4 2.1
Arm predicted mass (right) 0.4 2.0 7.0 2.6 -0.2 -2.2 1.0 0.1 1.1 0.3
Pulse rate, automated reading 1.8 5.8 7.9 -2.8 -2.1 2.5 -1.7 -2.4 -2.7 -2.4
Alcohol intake frequency. 6.2 14.4 29.4 5.4 2.6 -5.0 4.3 2.0 2.7 3.1
Comparative height size at age 10 1.8 10.1 15.0 -2.0 -3.6 2.6 -3.9 -3.2 -3.2 -3.4
Number of full sisters 0.1 0.1 0.3 0.1 0.1 -0.2 0.4 0.3 0.5 0.1
Suffer from ‘nerves’ 0.7 1.1 2.7 -1.7 -0.8 1.6 -0.5 -0.4 -0.7 -1.0
Overall health rating 0.5 1.0 4.1 0.6 0.7 -1.0 2.0 0.8 0.3 0.7
Chest pain or discomfort 0.7 1.0 1.5 0.9 1.0 -1.2 1.0 0.5 0.9 1.1
Had major operations 0.5 0.5 1.0 0.5 0.5 -1.0 0.6 0.8 1.0 0.6
Age at last live birth 0.7 1.0 2.1 -0.2 -1.4 0.7 -0.9 -0.9 -0.9 -1.3
Family relationship satisfaction 0.4 0.5 1.3 -0.9 0.5 0.6 0.0 1.1 0.6 0.4
Leg pain on walking 0.3 0.4 1.6 0.9 0.3 -1.2 0.2 0.1 0.5 0.4
Qualifications: NVQ or HND or HNC or equivalent 9.7 11.6 16.7 3.5 3.5 -4.1 3.3 2.7 3.0 3.6
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.1 -0.2 -0.7 0.4 -0.3 -1.4 -1.1 -0.8
Illness, injury, bereavement, stress in last 2 years 6.0 7.4 11.4 -2.8 -2.6 2.9 -3.4 -2.5 -2.0 -2.6
Medication: Aspirin 3.4 4.5 9.5 1.8 2.2 -1.6 3.1 2.0 1.7 2.1
Supplements: Vitamin C 0.2 0.2 0.7 0.8 0.5 -0.5 0.0 -0.0 0.2 0.5
Knee pain experienced in last month 0.1 0.2 0.4 -0.6 -0.4 -0.1 0.1 -0.6 -0.4 -0.3
Hypertension (Self-reported) 0.1 0.2 0.5 0.7 0.3 -0.3 0.4 -0.3 0.0 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.4 -1.0 -0.7 1.1 -0.6 -0.5 -1.2 -0.7
Illnesses of father: Heart disease 0.2 0.3 0.7 -0.2 0.9 0.1 0.7 0.7 0.1 0.7
Illnesses of siblings: Diabetes 3.5 4.4 6.8 1.9 2.0 -2.0 2.6 1.9 2.1 2.1
Smoking status: Previous 0.1 0.2 0.6 -0.4 -0.4 0.8 0.1 -0.1 -0.3 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.2 -0.1 -0.4 0.2 -0.4 -0.1 -0.3 -0.4
Whole body fat-free mass 0.4 2.4 8.9 3.0 -0.1 -2.3 0.9 0.4 1.1 0.4
Leg fat-free mass (right) 0.5 2.4 9.0 3.0 -0.1 -2.1 1.2 0.5 1.2 0.4
Arm fat percentage (left) 1.5 5.8 15.4 3.9 1.0 -3.4 2.6 1.0 1.8 1.4
Average weekly red wine intake 0.7 1.1 3.1 -0.3 -0.5 0.5 -1.7 -0.9 -1.7 -0.5
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 -0.5 -0.0 0.4 0.2 -0.2 0.4 -0.1
Mood swings 0.5 1.0 1.7 -0.4 1.2 -0.1 1.3 1.2 0.8 1.1
Loneliness, isolation 1.0 1.3 2.3 0.4 1.2 -0.6 1.5 1.5 1.3 1.1
Long-standing illness, disability or infirmity 0.6 1.0 2.4 1.2 0.4 -1.3 1.6 -0.6 -0.7 0.5
Ever had bowel cancer screening 0.1 0.1 0.4 0.6 0.1 -0.6 0.3 0.0 -0.1 0.1
Diabetes diagnosed by doctor 4.3 7.0 12.1 3.0 2.6 -2.6 3.5 2.1 1.8 2.7
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 3.9 -1.2 -1.0 0.9 -2.0 -0.4 0.0 -1.1
Friendships satisfaction 1.3 1.6 5.3 -2.3 -0.3 2.2 -0.8 0.4 -0.1 -0.5
Qualifications: nursing, teaching 1.0 1.5 4.9 0.5 -1.2 0.0 -2.2 -1.2 -1.1 -1.1
Commuting to job workplace: Walk 0.2 0.2 1.2 -0.1 0.1 -0.0 -0.1 0.5 1.1 0.1
Eye problems/disorders: Cataract 0.6 0.7 1.6 -0.1 -1.0 0.4 -0.0 -1.3 -1.0 -1.0
Mouth/teeth dental problems: Mouth ulcers 2.6 4.2 6.1 2.5 2.0 -2.5 0.8 1.8 2.1 2.1
Medication for cholesterol 0.2 0.3 2.0 -0.3 -0.1 0.0 -1.4 0.1 -0.4 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.4 -0.7 -0.3 0.5 -0.2 -0.2 -0.5 -0.3
Back pain experienced in last month 0.3 0.4 0.7 0.4 0.8 -0.6 0.5 0.3 0.7 0.8
Mineral and other dietary supplements 0.3 0.4 0.9 0.2 -0.8 0.3 0.5 -1.0 -0.6 -0.8
Breast cancer (self-reported) 1.3 1.5 2.7 1.1 1.6 -1.0 1.1 1.3 0.5 1.6
Asthma (self-reported) 0.5 1.0 2.0 -0.2 -1.4 0.5 -0.4 -1.2 -0.9 -1.3
Osteoporosis (self-reported) 3.0 3.7 5.6 -1.7 -2.4 2.1 -1.3 -2.0 -1.5 -2.3
Osteoarthritis (self-reported) 0.3 0.4 0.7 -0.8 -0.8 0.6 -0.1 -0.8 -0.3 -0.8
Medication: Aspirin 1.5 2.0 5.6 1.4 1.3 -1.1 2.4 1.2 0.7 1.3
Medication: Gliclazide 1.0 1.2 3.8 1.9 0.6 -1.5 1.0 0.3 0.2 0.9
Illnesses of father: None of the above (group 1) 1.3 1.7 2.8 -1.2 -1.5 0.9 -1.7 -1.1 -0.7 -1.6
Smoking status: Current 0.3 0.5 1.2 -0.3 -1.1 0.3 -0.2 -0.9 -0.7 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 3.6 1.9 1.4 -1.3 1.1 0.8 0.6 1.4
Whole body water mass 0.4 2.0 7.7 2.8 -0.1 -2.1 0.9 0.3 1.0 0.3
Leg predicted mass (right) 0.4 2.3 8.7 3.0 -0.1 -2.1 1.1 0.5 1.2 0.4
Arm fat mass (left) 1.4 5.6 15.4 3.9 0.8 -3.5 2.3 1.0 1.9 1.3
Number of self-reported non-cancer illnesses 0.5 0.8 2.2 1.2 0.6 -0.9 1.5 0.4 -0.1 0.7
Average weekly champagne plus white wine intake 1.3 1.8 5.4 -2.3 -0.5 1.9 -1.4 -0.3 -0.6 -0.9
Miserableness 0.3 0.5 0.8 -0.9 0.6 0.3 0.8 0.9 0.5 0.5
Guilty feelings 1.6 2.5 5.2 -0.1 1.6 -0.6 1.5 2.3 2.1 1.5
Wears glasses or contact lenses 0.1 0.2 0.5 0.2 0.1 0.1 -0.7 0.6 0.4 0.1
Ever taken oral contraceptive pill 2.5 2.8 5.8 -2.4 -1.3 2.2 -1.8 -0.7 -0.5 -1.6
Hearing aid user 6.0 6.8 11.2 3.3 2.5 -3.2 1.4 2.3 2.3 2.7
Mother’s age at death 1.3 1.7 2.1 1.5 1.3 -1.4 1.3 0.9 1.2 1.4
Financial situation satisfaction 0.4 0.5 2.0 -1.4 0.1 0.9 0.9 0.2 -0.1 -0.1
Tinnitus: Yes, now most or all of the time 2.1 2.5 4.0 2.0 1.6 -1.9 0.6 1.6 1.2 1.6
Commuting to job workplace: Public transport 0.3 0.4 1.5 -1.2 -0.2 0.5 0.7 -0.2 -0.5 -0.2
Eye problems/disorders: Glaucoma 3.5 4.2 6.9 1.9 2.2 -1.9 1.5 2.6 1.7 2.2
Medication: Blood pressure 0.2 0.3 1.0 0.4 -0.3 0.2 1.0 -0.7 -0.6 -0.3
Pain type(s) experienced in last month: Hip pain 1.8 2.2 3.4 0.7 1.9 -1.0 1.5 1.5 1.7 1.8
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.7 -0.7 0.6 0.3 -0.8 0.7 -0.1 0.5
High cholesterol (Self-reported) 0.4 0.7 1.3 -0.0 -1.1 -0.0 -1.0 -0.5 1.1 -0.9
Medication: Bendroflumethiazide 0.4 0.6 0.9 0.9 0.8 -0.7 1.0 -0.1 0.3 0.9
Medication: Paracetamol 1.3 2.1 5.2 1.1 1.4 -1.5 2.3 1.0 0.8 1.5
Medication: Lisinopril 0.8 1.0 1.9 1.4 0.7 -1.3 1.2 0.6 0.5 0.9
Medication: Atorvastatin 0.6 0.7 1.6 -0.8 0.2 1.1 -1.1 0.5 1.3 0.0
Illnesses of father: High blood pressure 0.2 0.2 0.9 0.6 -0.0 -0.3 1.0 0.1 0.1 0.1
Alcohol drinker status: Never 0.4 0.5 0.8 0.9 -0.1 -0.7 0.8 -0.9 -0.9 0.1
Ever smoked 0.4 0.7 1.4 -1.1 -0.9 1.2 0.3 -0.3 -0.6 -0.9
Basal metabolic rate 0.5 3.0 10.6 3.2 0.1 -2.6 1.2 0.5 1.3 0.6
Leg fat percentage (left) 2.6 9.4 17.0 4.1 2.1 -4.1 3.3 1.8 2.7 2.4
Arm fat-free mass (left) 0.6 3.0 8.2 2.9 0.4 -2.5 1.5 0.8 1.6 0.8
Number of operations (self-reported) 0.6 0.8 1.7 -1.3 -1.0 0.6 -1.0 -0.8 -0.7 -1.0
Average weekly beer plus cider intake 0.0 0.0 0.2 -0.2 -0.0 0.1 0.5 0.1 -0.0 -0.0
Irritability 1.5 2.6 7.1 1.1 1.3 -1.1 0.7 2.1 2.7 1.4
Risk taking 3.5 5.1 7.0 0.8 2.6 -1.7 2.5 2.5 2.5 2.4
Ever had prostate specific antigen (PSA) test 0.9 1.0 2.4 -0.5 -0.7 0.8 -1.6 -0.7 -1.4 -0.9
Fractured/broken bones in last 5 years 3.2 4.1 6.8 1.1 1.9 -1.6 2.6 2.5 2.2 1.8
Age started oral contraceptive pill 0.5 0.7 1.4 1.2 0.4 -0.9 -0.0 0.9 1.2 0.5
Diastolic blood pressure, automated reading 0.5 1.5 4.1 0.8 -1.2 -0.6 -0.2 -2.0 -1.7 -0.9
Ever depressed for a whole week 0.1 0.1 0.2 -0.2 -0.3 0.0 0.0 0.4 0.3 -0.3
Unable to work because of sickness or disability 0.1 0.2 0.4 0.4 0.1 -0.7 0.7 0.0 0.3 0.1
Commuting to job workplace: Cycle 2.2 2.7 6.1 0.8 1.7 -1.1 2.5 2.1 0.9 1.6
Myopia 1.5 2.2 3.4 -1.3 -1.6 1.7 -1.9 -1.1 -0.4 -1.7
Vascular/heart problems diagnosed by doctor 0.1 0.4 1.2 0.2 0.6 -0.5 0.2 1.1 0.7 0.5
Cholesterol lowering medication 0.1 0.2 0.3 0.4 -0.5 0.1 0.3 -0.4 0.5 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.6 -0.3 -0.4 0.2 -0.3 -0.4 -0.8 -0.4
Pain experienced in last month 0.7 1.2 2.3 -0.5 -1.5 1.4 -1.1 -0.8 -0.3 -1.4
Supplements: Calcium 0.1 0.1 0.7 -0.1 -0.1 -0.1 -0.8 0.5 0.1 -0.1
Basal cell carcinoma (self-reported) 0.2 0.3 0.9 -0.1 0.3 0.4 -0.6 0.7 1.0 0.2
Heart attack/myocardial infarction (self-reported) 0.6 0.7 1.9 -0.5 -0.7 0.5 -0.5 -1.2 -1.4 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 2.0 1.4 0.7 -1.0 0.6 0.8 0.1 0.8
Heart disease (siblings) 3.0 3.7 7.8 1.9 1.6 -2.3 2.8 1.2 1.4 1.7
Alcohol drinker status: Previous 0.3 0.3 0.8 0.9 -0.2 -0.6 0.8 -0.4 -0.6 -0.1
Pack years of smoking 0.8 1.2 2.6 1.4 0.7 -1.6 0.9 0.6 1.2 0.9
Impedance of whole body 1.1 5.6 11.9 -3.1 -1.4 2.6 -3.5 -1.2 -2.0 -1.7
Leg fat mass (left) 2.1 8.0 17.9 4.2 1.5 -3.9 3.0 1.4 2.4 1.9
Arm predicted mass (left) 0.6 3.0 8.6 2.9 0.3 -2.6 1.3 0.7 1.7 0.8