Hub : Genes

H2AFV

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1410	0.0360	7.4e-09	0.076	0.079	0.067	0.084	0.085	1.6e-09	6.7e-10	1.4e-08	1.9e-10	1.8e-10
2	GTEx	Artery Aorta	0.1020	0.0470	5.5e-03	0.080	NA	0.027	NA	0.065	3.4e-05	NA	1.3e-02	NA	1.9e-04
3	GTEx	Testis	0.2190	0.0770	1.6e-03	0.058	NA	0.008	NA	0.049	1.4e-03	NA	1.4e-01	NA	3.2e-03
4	GTEx	Thyroid	0.1470	0.0550	1.2e-03	0.036	NA	0.037	NA	0.076	8.5e-04	NA	8.0e-04	NA	1.8e-06
5	TCGA	Breast Invasive Carcinoma	0.0459	0.0243	1.6e-07	0.038	0.037	0.033	NA	0.036	2.1e-08	4.5e-08	1.7e-07	NA	4.7e-08
6	TCGA	Prostate Adenocarcinoma	0.0818	0.0503	9.1e-05	0.034	0.050	0.055	NA	0.046	1.6e-04	6.2e-06	1.9e-06	NA	1.3e-05
7	TCGA	Thyroid Carcinoma	0.1450	0.0620	1.4e-12	0.141	0.136	0.132	NA	0.141	1.3e-13	4.0e-13	7.7e-13	NA	1.3e-13

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.3	0.5	2.2	-0.1	0.7	-0.2	1.5	0.8	0.2	0.6
Bipolar Disorder or Schizophrenia	0.5	1.2	2.0	0.1	1.4	-0.5	1.1	1.3	1.4	1.2
Depressed Affect (Nagel 2018)	0.3	0.6	1.1	-0.4	0.9	0.0	1.1	1.1	0.8	0.8
Depression (Nagel 2018)	0.8	1.3	3.8	1.2	0.7	-1.0	2.0	0.8	1.0	0.7
Intelligence (Savage-Jansen 2018)	6.8	20.9	40.8	-4.1	-4.8	4.7	-6.4	-3.5	-2.8	-4.8
Neuroticism (Nagel 2018)	0.5	1.1	2.0	-0.1	1.3	-0.3	1.1	1.4	1.0	1.2
Schizophrenia (2018)	0.4	0.9	2.3	0.3	1.2	-0.6	0.2	1.0	1.5	1.0
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	-0.3	0.8	0.1	-0.6	0.7	0.9	0.7
Worry (Nagel 2018)	0.1	0.2	0.6	-0.8	-0.2	0.5	0.0	0.0	-0.7	-0.3
Alzheimer’s Disease (in mother)	0.9	1.0	3.2	1.8	0.5	-1.5	-0.2	0.5	0.8	0.8
Alzheimer’s Disease (in father)	0.5	0.5	3.0	-1.7	0.4	0.5	-0.2	0.3	0.1	0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	-0.0	0.5	-0.6	-0.1	0.4	0.5	0.5
Crohns Disease (2017)	0.5	1.1	3.0	-1.7	-0.4	1.4	-0.8	-0.5	-1.2	-0.6
Irritable Bowel Disease (IBD)	1.3	3.1	4.6	-2.2	-1.5	2.1	-1.9	-1.1	-1.7	-1.6
Ulcerative Colitis (UC)	1.1	2.1	3.5	-1.2	-1.7	1.5	-1.9	-0.9	-1.1	-1.7
Major Depression (MDD)	2.5	3.0	6.4	-2.5	-1.6	2.1	-1.3	-1.2	-1.2	-1.8
Reaction Time	1.0	1.9	4.4	0.3	2.0	-0.9	2.1	0.7	-0.7	1.7
Verbal and Numeric Reasoning (VNR)	3.9	9.4	18.9	-2.8	-3.1	3.3	-4.3	-2.1	-2.0	-3.2
Breast Cancer	0.9	2.1	4.4	-0.2	2.1	-0.9	2.1	1.0	0.6	1.9
Ovarian Cancer	0.6	0.7	2.1	0.3	1.4	-0.8	-0.2	0.8	0.1	1.2
Prostate Cancer	0.2	0.3	1.2	-1.1	0.2	0.6	-0.0	0.2	-0.4	-0.0
Age at First Birth	2.7	3.9	8.4	-2.8	-1.7	2.9	-1.7	-0.7	-0.8	-2.1
Bipolar Disorder (2011)	1.5	1.4	8.5	1.2	0.0	0.0	2.9	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	1.8	0.4	-1.3	0.1	0.2	-1.3	-0.4	-1.1
Coronary Artery Disease (CAD)	4.6	5.5	7.7	-2.8	-2.5	2.3	-1.5	-2.3	-2.4	-2.5
Crohns Disease (2012)	0.1	0.1	0.4	-0.4	0.6	0.1	0.2	0.2	0.1	0.5
Mean Putamen Volume	0.2	0.2	0.9	-0.2	0.1	0.3	1.0	0.8	0.2	0.1
Fasting Glucose	0.4	0.5	1.5	1.2	0.4	-0.8	0.6	0.3	0.3	0.6
HbA1C	0.2	0.2	0.6	0.5	0.1	-0.4	0.8	-0.5	-0.4	0.1
HDL Cholesterol	0.3	0.5	1.2	-1.1	0.8	0.8	0.6	0.6	0.1	0.4
LDL Cholesterol	0.7	1.2	1.8	-0.7	-1.4	0.6	-1.2	-1.2	-1.0	-1.2
Lupus	0.3	0.5	1.6	0.1	-0.9	0.2	-0.5	-1.3	-0.4	-0.8
Neuroticism (2016)	0.8	1.2	2.4	-0.6	1.2	0.4	1.6	1.3	1.1	1.1
Primary Biliary Cirrhosis	6.0	8.5	11.9	-2.6	-3.1	2.6	-2.5	-3.5	-3.0	-3.1
Rheumatoid Arthritis	0.5	0.7	1.3	0.9	0.9	-1.1	1.1	-0.0	-0.1	0.9
Schizophrenia (2014)	0.7	1.6	3.1	-0.1	1.7	-0.4	0.9	1.6	1.8	1.4
Triglycerides	0.1	0.1	0.3	-0.1	-0.5	-0.1	0.3	-0.3	-0.4	-0.4
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.8	0.7	1.2	-1.2	0.4	0.3	0.5	1.4
Ulcerative Colitis	1.2	1.7	2.3	-1.3	-1.5	1.5	-1.0	-1.1	-1.1	-1.5
Blood Eosinophil Count	1.2	9.3	22.2	4.7	2.2	-3.7	2.5	2.2	2.4	2.8
Blood Platelet Count	19.6	227.3	309.8	17.6	14.7	-17.4	13.9	12.6	12.8	15.7
Blood Red Count	19.0	183.3	249.6	15.5	13.1	-15.8	12.0	11.2	12.6	13.9
Blood White Count	5.0	36.8	65.1	8.1	5.2	-7.3	6.1	4.1	4.9	5.8
Heel T-Score	0.2	1.6	3.4	1.7	0.9	-1.9	1.4	0.3	0.9	1.1
BMI	2.1	12.2	23.1	4.8	1.9	-4.4	4.5	2.1	3.0	2.3
Height	1.0	19.8	40.1	-3.3	-5.2	3.6	-6.3	-3.7	-3.3	-4.9
Waist Hip Ratio (WHR)	0.1	0.5	2.1	-1.4	0.1	1.0	0.3	0.3	-0.2	-0.1
Systolic Blood Pressure	0.1	0.3	0.7	0.6	0.0	-0.6	0.8	-0.6	0.7	0.2
Smoking Status	0.1	0.3	0.9	1.0	-0.4	-0.4	0.7	-0.4	-0.0	-0.1
Allergy or Eczema	0.7	1.8	7.0	-0.8	-0.5	1.1	-1.1	-1.3	-2.6	-0.6
Cardiovascular Disease	0.1	0.4	1.4	1.0	0.0	-0.7	1.2	-0.5	0.1	0.2
Hypothyroidism (self reported)	0.6	1.3	3.0	-0.1	-1.7	0.6	-1.5	-0.8	-0.5	-1.6
Respiratory disease	0.7	1.5	3.9	-0.6	-1.3	0.7	-0.3	-1.5	-2.0	-1.3
Type 2 Diabetes (T2D) (2018)	3.0	5.6	10.0	2.5	2.5	-2.0	3.2	2.1	1.4	2.5
Lung FEV1/FVC ratio	0.3	1.6	3.0	1.7	0.7	-1.4	0.8	1.1	1.7	0.9
Lung FVC	0.2	1.0	2.1	0.6	1.2	-0.9	1.4	0.3	0.6	1.1
Neuroticism	0.8	1.9	4.9	-0.0	1.4	-0.5	2.2	1.6	1.4	1.4
Chronotype (morning person)	0.6	1.4	2.4	0.3	1.5	-0.9	1.4	1.3	0.6	1.4
Hair Pigment	0.0	0.6	1.4	0.5	-0.9	-0.6	-0.0	-1.2	-0.9	-0.6
Tanning	0.2	2.3	5.9	0.4	2.4	-1.1	0.6	1.8	0.6	2.2
Hand grip strength (left)	0.1	0.3	1.0	-0.4	-0.0	0.7	-1.0	-0.1	0.7	-0.1
Number of treatments/medications taken	0.2	0.3	1.6	0.1	0.4	-0.1	1.3	0.0	-0.2	0.4
Average weekly spirits intake	0.3	0.3	0.9	0.7	-0.0	-0.6	-0.7	0.2	0.9	0.1
Sensitivity / hurt feelings	0.5	0.9	1.3	0.9	1.1	-1.0	0.8	0.9	0.8	1.1
Frequency of depressed mood in last 2 weeks	0.2	0.2	1.0	0.2	-0.3	0.3	1.0	0.2	0.6	-0.3
Hearing difficulty/problems: Yes	0.4	0.6	1.3	0.4	0.4	-0.7	-0.8	1.1	1.1	0.5
Relative age of first facial hair	2.1	4.4	5.8	-2.2	-2.1	2.0	-2.4	-1.9	-1.9	-2.0
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.2	-0.9	-1.1	0.9	0.2	-1.4	-1.8	-1.1
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.8	-0.7	0.8	0.1	1.0	1.4	0.8	0.7
Ever had hysterectomy (womb removed)	0.5	0.6	1.3	0.1	-1.1	0.4	-0.5	-0.8	-0.9	-1.0
Systolic blood pressure, automated reading	0.6	1.8	4.7	2.2	0.7	-1.7	1.4	0.2	1.2	0.9
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	3.3	-0.0	1.6	-0.5	1.8	1.8	0.2	1.3
Angina	0.1	0.2	1.1	-0.3	0.3	0.0	1.1	0.2	0.0	0.2
Medication for hormone replacement therapy	0.8	0.9	1.4	-0.8	1.2	0.2	1.1	1.0	0.9	0.9
Vitamin and mineral supplements	0.1	0.1	0.5	0.1	-0.1	0.1	0.1	-0.4	-0.7	-0.0
Supplements: Zinc	0.1	0.1	0.3	-0.1	0.4	-0.2	-0.4	0.4	0.5	0.3
Medication: Co-codamol	1.4	1.6	3.9	0.7	1.5	-1.1	2.0	1.0	0.7	1.4
Medication: Metformin	3.0	4.2	8.2	1.6	2.1	-1.6	2.9	2.1	1.8	2.1
Diabetes (father)	0.3	0.4	0.8	-0.4	-0.6	0.7	-0.4	-0.9	-0.8	-0.6
Diabetes (mother)	1.3	1.6	3.2	-0.3	1.5	-0.1	1.8	1.8	0.8	1.4
Severe depression (siblings)	1.3	1.5	2.9	0.8	1.7	-0.6	1.5	1.3	-0.0	1.6
Pack years adult smoking proportion	0.9	1.4	2.8	1.5	0.8	-1.7	0.9	0.7	1.3	1.0
Impedance of leg (right)	0.5	2.4	5.8	-2.4	-0.4	1.5	-2.4	-0.6	-1.4	-0.7
Leg fat-free mass (left)	0.7	3.7	12.8	3.6	0.3	-2.7	1.5	0.8	1.4	0.9
Trunk fat percentage	0.7	2.6	8.6	2.9	0.2	-2.5	1.4	0.3	1.1	0.6
Hand grip strength (right)	0.2	0.5	2.0	0.3	0.6	-0.2	-0.3	0.7	1.4	0.7
Townsend deprivation index at recruitment	1.9	2.7	3.4	1.1	1.8	-1.6	1.9	1.5	1.6	1.8
Current tobacco smoking	0.1	0.2	0.6	0.2	-0.8	-0.2	0.2	-0.7	-0.4	-0.6
Average weekly fortified wine intake	0.7	0.8	2.3	0.7	-0.7	0.1	-1.3	-0.6	-1.5	-0.5
Maternal smoking around birth	0.8	1.2	2.2	0.5	1.0	-0.8	1.5	1.4	1.1	1.0
Fed-up feelings	1.6	2.8	4.9	0.9	1.8	-1.4	2.2	1.7	1.7	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	4.8	6.4	13.0	2.5	2.2	-2.6	3.6	2.0	2.2	2.3
Relative age voice broke	0.6	0.9	1.6	-0.9	-0.9	0.9	-1.2	-0.5	-1.1	-0.8
Taking other prescription medications	0.2	0.3	1.0	-0.2	0.6	0.1	1.0	0.5	-0.1	0.4
Age when periods started (menarche)	0.1	0.2	0.7	0.3	-0.5	0.4	-0.8	-0.2	-0.4	-0.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.9	0.8	0.5	-0.7	0.5	0.6	1.4	0.6
Heel bone mineral density (BMD) T-score, automated (left)	2.4	5.5	8.4	1.5	2.6	-2.2	2.9	2.1	2.4	2.5
Tinnitus: Yes, but not now, but have in the past	1.9	2.1	5.6	2.4	1.1	-2.1	0.9	0.5	0.5	1.4
Qualifications: CSEs or equivalent	2.0	2.7	4.3	1.8	1.0	-2.1	2.1	1.1	1.8	1.1
Serious illness, injury or assault to yourself	1.5	1.9	3.5	1.2	1.3	-1.3	1.9	1.6	0.8	1.2
High blood pressure	0.0	0.1	0.3	0.5	0.1	-0.3	0.4	-0.5	0.0	0.3
Hayfever, allergic rhinitis or eczema	0.9	2.0	5.9	-0.8	-0.6	0.9	-1.9	-1.4	-2.4	-0.6
Multivitamins +/- minerals	0.3	0.4	1.1	-0.3	0.2	-0.0	-0.5	1.0	1.1	0.1
Stomach or abdominal pain in last month	0.1	0.2	0.5	0.2	-0.0	-0.4	-0.2	-0.5	-0.7	0.1
Supplements: Glucosamine	0.6	0.8	3.1	-1.8	-0.0	1.4	-0.3	0.4	0.4	-0.2
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.0	-0.3	-0.5	0.5	0.4	-1.1	-1.4	-0.4
Medication: Atenolol	0.2	0.2	1.1	-0.5	0.0	0.3	1.0	-0.4	-0.1	0.0
Medication: Levothyroxine sodium	0.1	0.2	0.8	0.2	-0.3	-0.2	-0.9	0.2	0.5	-0.3
Sitting height	0.4	2.7	10.2	-0.4	-1.4	0.4	-3.2	-1.5	-1.5	-1.2
Chronic bronchitis/emphysema (father)	1.1	1.3	3.6	1.9	0.7	-1.3	1.1	0.1	0.9	0.9
High blood pressure (mother)	1.4	2.0	4.4	0.8	1.3	-1.1	2.1	1.0	1.7	1.4
Body mass index (BMI)	3.0	12.8	25.6	5.1	2.2	-4.6	4.2	1.9	3.1	2.6
Impedance of leg (left)	1.0	4.7	11.7	-3.4	-0.9	2.4	-3.0	-1.0	-1.6	-1.3
Leg predicted mass (left)	0.7	3.6	12.8	3.6	0.3	-2.7	1.6	0.7	1.3	0.8
Trunk fat mass	0.8	3.6	11.8	3.4	0.3	-2.9	1.5	0.5	1.4	0.8
Waist circumference	0.8	2.9	7.7	2.8	0.6	-2.4	2.0	0.7	1.2	0.9
Number of incorrect matches in round	0.5	0.8	2.4	-1.5	0.7	1.1	-0.2	1.0	0.6	0.3
Past tobacco smoking	0.2	0.3	0.8	0.8	0.6	-0.9	-0.2	0.2	0.4	0.6
Alcohol usually taken with meals	0.7	1.1	3.9	-2.0	-0.3	1.5	-0.6	0.6	0.4	-0.5
Nervous feelings	1.6	3.0	5.1	-2.3	-1.9	2.2	-1.2	-1.0	-1.1	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.3	0.0	0.1	0.1	0.4	-0.1	-0.6	0.2
Hearing difficulty/problems with background noise	1.6	2.6	10.3	-1.7	-0.9	1.7	-3.2	-0.2	0.3	-1.0
Hair/balding pattern: Pattern 2	0.9	1.1	1.9	1.1	0.8	-1.0	1.4	0.9	1.3	0.8
Had menopause	1.0	1.2	3.0	-1.7	-1.0	1.6	-0.9	-0.4	0.1	-1.1
Had other major operations	0.4	0.4	1.7	-1.3	-0.1	1.0	-0.4	0.1	-0.3	-0.2
Forced vital capacity (FVC)	0.2	0.9	1.9	1.4	0.9	-1.3	-0.3	0.7	0.4	1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	5.7	0.5	2.2	-1.4	2.4	1.9	2.0	2.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	-0.1	-0.5	0.2	-0.6	0.2	0.4	-0.4
Qualifications: None of the above	1.0	2.2	10.4	1.5	0.1	-1.4	3.2	-0.6	-0.2	0.3
Financial difficulties in last 2 years	0.7	0.9	2.6	-0.1	1.0	-0.3	1.6	1.0	1.0	0.8
Mouth/teeth dental problems	7.1	10.8	13.5	-2.4	-3.6	3.4	-2.8	-3.4	-3.7	-3.5
Heart attack	0.5	0.7	1.8	-0.5	-0.6	0.5	-0.3	-1.2	-1.4	-0.7
Allergy	0.5	1.1	4.7	0.1	0.4	-0.5	1.0	1.1	2.2	0.4
Pain all over the body in last month	0.1	0.1	0.2	0.3	-0.4	-0.4	-0.3	-0.4	-0.2	-0.3
Diabetes (self-reported)	3.8	5.9	7.8	2.4	2.8	-2.1	2.8	2.2	1.8	2.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.2	-0.0	0.2	0.1	-1.1	0.4	-0.6	0.3
Medication: Ramipril	0.4	0.6	3.6	0.5	0.0	-0.1	-1.9	-0.3	0.2	0.2
Medication: Simvastatin	0.3	0.4	0.9	0.8	-0.5	-0.4	0.4	-0.9	-0.8	-0.3
Fluid intelligence score	5.1	10.6	23.0	-3.2	-3.1	3.7	-4.8	-1.9	-2.0	-3.2
Illnesses of siblings	0.5	0.7	1.6	-1.2	-0.5	1.2	-0.9	0.1	-0.6	-0.7
Neuroticism score	0.7	1.4	3.2	0.5	1.1	-0.8	1.8	1.4	1.2	1.1
Weight	0.9	4.6	14.1	3.8	0.5	-3.2	1.9	0.8	1.7	1.0
Impedance of arm (right)	0.7	3.2	8.0	-2.2	-1.0	2.0	-2.8	-0.5	-1.7	-1.2
Arm fat percentage (right)	1.6	6.2	15.1	3.9	1.2	-3.4	2.7	1.3	1.9	1.6
Trunk fat-free mass	0.2	1.4	5.8	2.4	-0.3	-1.9	0.4	0.2	0.6	0.2
Hip circumference	0.4	1.8	7.8	2.8	-0.3	-2.0	0.4	-0.1	0.7	0.1
Time employed in main current job	0.7	0.8	1.9	0.7	-1.1	0.2	-0.4	-1.4	-0.8	-0.9
Alcohol intake versus 10 years previously	0.6	0.8	2.1	1.2	0.7	-1.4	0.3	0.6	0.8	0.8
Father’s age at death	0.3	0.4	1.0	-1.0	-0.3	0.8	-0.6	-0.1	-0.5	-0.4
Worrier / anxious feelings	0.1	0.1	0.3	0.5	0.2	-0.4	0.1	0.3	-0.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	-0.8	-0.6	0.4	0.5	-0.4	-0.4	-0.7
Falls in the last year	0.3	0.4	1.0	0.9	0.0	-1.0	0.2	-0.6	0.6	0.1
Hair/balding pattern: Pattern 3	0.7	1.0	3.5	-1.9	-0.4	1.3	-0.5	-0.6	-0.6	-0.5
Number of live births	0.7	1.0	1.9	-1.4	-0.9	1.2	-0.5	-1.0	-0.7	-1.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.8	2.0	1.2	-1.8	0.0	1.0	0.9	1.4
Pulse rate	1.6	2.7	6.9	-2.6	-1.0	2.0	-0.7	-1.4	-1.7	-1.4
Happiness	0.6	0.7	2.0	-1.4	-0.6	1.4	-0.0	-0.0	0.1	-0.7
Noisy workplace	12.9	15.9	25.5	3.5	4.0	-4.0	5.0	3.7	3.5	4.0
Qualifications: A levels/AS levels or equivalent	1.4	3.2	5.9	-2.4	-1.4	2.4	-1.7	-0.8	-1.6	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.3	0.9	0.8	-0.9	0.5	1.0	1.1	0.8
Mouth/teeth dental problems: Dentures	0.6	1.0	2.1	0.9	0.8	-1.4	1.0	0.5	1.2	0.9
Asthma	0.7	1.4	3.0	-0.1	-1.7	0.5	-0.6	-1.5	-1.2	-1.6
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	5.1	1.2	1.0	-1.4	2.3	0.8	1.1	1.0
Medication: Cholesterol lowering	0.1	0.1	0.6	0.0	-0.3	-0.0	-0.1	-0.8	-0.2	-0.3
Depression (self-reported)	1.3	1.6	2.9	1.1	0.9	-1.1	1.7	1.5	1.4	0.9
Medication: Lansoprazole	0.4	0.5	1.2	1.1	0.7	-0.8	0.7	0.2	0.5	0.7
Prospective memory result	0.2	0.2	1.5	0.2	0.2	-0.3	1.2	-0.2	0.0	0.2
Lung cancer (father)	0.4	0.4	0.9	0.2	0.6	-0.6	-0.9	0.4	0.9	0.6
Illnesses of mother	1.7	2.1	6.9	-0.9	-1.2	0.9	-2.6	-0.9	-1.3	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	2.5	1.6	1.3	-1.3	0.1	1.2	1.3	1.4
Pulse wave Arterial Stiffness index	0.5	0.6	1.0	-0.9	-0.7	1.0	-0.8	-0.0	-0.6	-0.8
Impedance of arm (left)	1.3	6.0	12.3	-2.7	-1.8	2.7	-3.5	-1.4	-2.5	-2.0
Arm fat mass (right)	1.4	5.9	16.2	4.0	0.8	-3.5	2.4	1.0	2.0	1.3
Trunk predicted mass	0.3	1.5	6.0	2.4	-0.2	-1.9	0.5	0.2	0.7	0.3
Standing height	0.9	9.0	21.6	-2.1	-3.2	2.5	-4.7	-2.1	-2.5	-3.0
Length of working week for main job	1.5	1.7	4.7	2.2	0.6	-1.9	1.1	0.5	1.1	0.8
Exposure to tobacco smoke at home	0.4	0.5	1.2	-1.1	-0.2	1.0	-0.8	-0.5	-0.4	-0.4
Breastfed as a baby	0.2	0.3	0.8	0.5	0.6	-0.2	0.1	0.9	0.5	0.5
Tense / ‘highly strung’	0.4	0.7	2.9	-0.4	0.5	-0.4	0.4	1.1	1.7	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	-0.3	0.2	0.1	-0.3	1.0	0.9	0.1
Hair/balding pattern: Pattern 4	0.1	0.4	1.0	0.7	0.4	-0.4	0.2	0.7	1.0	0.5
Birth weight of first child	0.9	1.7	3.5	-1.1	-1.7	0.9	-1.9	-0.8	-0.7	-1.6
Peak expiratory flow (PEF)	0.9	2.2	6.5	2.5	0.8	-2.2	1.0	0.9	0.8	1.0
Pulse wave reflection index	0.3	0.3	1.3	-0.0	-0.0	0.2	-0.7	1.1	0.8	-0.1
Ever highly irritable/argumentative for 2 days	1.2	1.4	4.0	2.0	0.4	-1.5	0.9	0.7	1.3	0.6
Loud music exposure frequency	1.6	1.7	2.5	1.6	1.4	-1.5	1.4	0.9	0.6	1.5
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.9	-0.4	-0.4	0.5	-1.7	-0.2	-0.4	-0.5
Mouth/teeth dental problems: Bleeding gums	1.8	2.4	4.2	0.4	2.0	-1.1	1.4	1.7	1.6	1.9
Blood clot in the leg (DVT)	0.3	0.3	1.0	1.0	0.4	-0.7	0.3	0.6	0.0	0.4
Medication: Paracetamol	0.9	1.5	3.8	0.5	1.4	-1.2	2.0	1.0	0.7	1.4
Headache pain in last month	0.1	0.2	0.5	0.6	0.6	-0.7	0.3	0.2	-0.3	0.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.9	-0.6	0.2	0.4	-0.2	0.9	0.4	0.1
Glaucoma (self-reported)	2.8	3.3	7.3	0.8	2.2	-1.4	1.5	2.7	1.4	2.1
Gout (self-reported)	0.3	0.4	1.0	1.0	0.4	-0.8	0.7	0.2	-0.3	0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.6	0.2	-1.3	0.3	-1.2	-0.6	-0.2	-1.1
Medication: Amlodipine	1.3	1.8	2.7	0.9	1.5	-1.1	1.7	1.4	1.3	1.4
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.3	-1.1	-0.8	1.0	-1.1	-0.5	-0.8	-0.9
Birth weight	0.3	0.5	2.3	-1.5	-0.1	1.2	0.1	-0.0	0.0	-0.3
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.4	0.1	0.0	0.3	1.2	0.1	-0.7	0.0
High blood pressure (siblings)	0.4	0.5	0.9	-0.9	-0.6	0.8	-0.3	-1.0	-0.7	-0.6
Forced vital capacity (FVC), Best measure	0.1	0.2	0.8	0.6	0.3	-0.2	-0.9	0.2	0.3	0.4
Body fat percentage	1.2	4.7	12.0	3.5	0.9	-3.1	2.3	0.9	1.7	1.3
Leg fat percentage (right)	3.1	11.3	21.3	4.6	2.4	-4.5	3.7	2.0	2.7	2.7
Arm fat-free mass (right)	0.6	2.9	8.7	3.0	0.2	-2.5	1.5	0.5	1.4	0.6
Exposure to tobacco smoke outside home	4.4	5.9	9.5	2.1	2.5	-2.6	2.0	1.7	3.1	2.6
Comparative body size at age 10	0.5	1.4	5.4	2.3	0.1	-1.9	-0.1	0.0	0.8	0.3
Number of full brothers	2.0	2.5	5.0	0.8	1.5	-1.1	1.8	1.6	2.2	1.5
Worry too long after embarrassment	4.8	8.0	11.4	1.7	3.3	-2.3	2.5	3.4	2.9	3.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.8	-0.6	-0.7	0.9	-0.5	-0.3	0.0	-0.8
Wheeze or whistling in the chest in last year	2.5	4.4	6.3	1.9	2.1	-2.1	2.5	1.9	1.8	2.2
Number of children fathered	1.8	2.0	2.9	1.0	1.6	-1.3	1.7	1.7	0.8	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	0.9	0.9	0.7	-0.7	0.4	0.6	0.8	0.8
Age at first live birth	1.0	1.8	2.6	-1.4	-1.5	1.6	-1.3	-0.9	-1.2	-1.5
Pulse wave peak to peak time	0.5	0.6	1.1	1.0	0.7	-1.0	0.8	0.1	0.6	0.9
Health satisfaction	0.1	0.1	0.6	-0.2	0.1	0.2	-0.0	-0.1	-0.8	0.1
Shortness of breath walking on level ground	0.1	0.1	0.3	0.1	0.4	0.1	0.6	-0.0	-0.4	0.3
Qualifications: College or University degree	4.5	14.0	23.9	-3.9	-3.3	4.2	-4.9	-2.5	-3.5	-3.5
Eye problems/disorders: None of the above	1.0	1.1	2.1	-0.8	-1.3	0.9	-1.5	-1.0	-0.3	-1.2
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	-0.5	0.8	-0.3	0.4	0.5	-0.5	0.6
Emphysema/chronic bronchitis	0.3	0.3	1.2	0.5	0.5	-0.6	1.1	0.2	-0.1	0.5
Medication for pain relief, constipation, heartburn	2.5	4.3	10.0	-1.4	-2.2	1.9	-3.2	-1.8	-1.3	-2.2
Neck or shoulder pain in last month	0.3	0.5	1.2	0.2	1.1	-0.4	0.6	0.4	0.4	1.0
Medication: Blood pressure	0.2	0.4	0.8	0.8	0.8	-0.8	0.3	0.1	0.1	0.9
Angina (self-reported)	0.1	0.1	0.8	-0.3	0.1	0.1	0.9	-0.1	-0.3	0.0
Migraine (self-reported)	0.1	0.1	0.5	-0.7	0.4	0.3	0.2	0.1	-0.1	0.2
Medication: Ibuprofen	1.6	2.0	4.1	1.7	1.1	-1.6	2.0	0.8	1.0	1.1
Medication: Allopurinol	0.8	1.1	3.0	1.7	0.8	-1.6	0.4	0.5	0.4	0.8
Medication: Omeprazole	0.7	0.9	2.0	-0.7	-0.9	0.8	-0.6	-0.9	-1.4	-0.9
Medication: Seretide 50 evohaler	0.0	0.0	0.1	-0.1	-0.2	-0.2	0.0	0.3	0.0	-0.2
Mean time to correctly identify matches	0.8	1.5	3.9	0.2	1.8	-0.6	2.0	0.2	-0.8	1.5
Heart disease (mother)	1.1	1.3	5.5	0.7	1.1	-0.6	2.4	0.6	0.4	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.9	-0.2	-0.3	0.6	-0.5	-0.7	-1.0	-0.4
Whole body fat mass	1.1	4.5	13.1	3.6	0.5	-3.2	1.9	0.7	1.6	1.0
Leg fat mass (right)	2.3	8.8	19.7	4.4	1.7	-4.1	3.1	1.5	2.4	2.1
Arm predicted mass (right)	0.4	2.0	7.0	2.6	-0.2	-2.2	1.0	0.1	1.1	0.3
Pulse rate, automated reading	1.8	5.8	7.9	-2.8	-2.1	2.5	-1.7	-2.4	-2.7	-2.4
Alcohol intake frequency.	6.2	14.4	29.4	5.4	2.6	-5.0	4.3	2.0	2.7	3.1
Comparative height size at age 10	1.8	10.1	15.0	-2.0	-3.6	2.6	-3.9	-3.2	-3.2	-3.4
Number of full sisters	0.1	0.1	0.3	0.1	0.1	-0.2	0.4	0.3	0.5	0.1
Suffer from ‘nerves’	0.7	1.1	2.7	-1.7	-0.8	1.6	-0.5	-0.4	-0.7	-1.0
Overall health rating	0.5	1.0	4.1	0.6	0.7	-1.0	2.0	0.8	0.3	0.7
Chest pain or discomfort	0.7	1.0	1.5	0.9	1.0	-1.2	1.0	0.5	0.9	1.1
Had major operations	0.5	0.5	1.0	0.5	0.5	-1.0	0.6	0.8	1.0	0.6
Age at last live birth	0.7	1.0	2.1	-0.2	-1.4	0.7	-0.9	-0.9	-0.9	-1.3
Family relationship satisfaction	0.4	0.5	1.3	-0.9	0.5	0.6	0.0	1.1	0.6	0.4
Leg pain on walking	0.3	0.4	1.6	0.9	0.3	-1.2	0.2	0.1	0.5	0.4
Qualifications: NVQ or HND or HNC or equivalent	9.7	11.6	16.7	3.5	3.5	-4.1	3.3	2.7	3.0	3.6
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.1	-0.2	-0.7	0.4	-0.3	-1.4	-1.1	-0.8
Illness, injury, bereavement, stress in last 2 years	6.0	7.4	11.4	-2.8	-2.6	2.9	-3.4	-2.5	-2.0	-2.6
Medication: Aspirin	3.4	4.5	9.5	1.8	2.2	-1.6	3.1	2.0	1.7	2.1
Supplements: Vitamin C	0.2	0.2	0.7	0.8	0.5	-0.5	0.0	-0.0	0.2	0.5
Knee pain experienced in last month	0.1	0.2	0.4	-0.6	-0.4	-0.1	0.1	-0.6	-0.4	-0.3
Hypertension (Self-reported)	0.1	0.2	0.5	0.7	0.3	-0.3	0.4	-0.3	0.0	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.4	-1.0	-0.7	1.1	-0.6	-0.5	-1.2	-0.7
Illnesses of father: Heart disease	0.2	0.3	0.7	-0.2	0.9	0.1	0.7	0.7	0.1	0.7
Illnesses of siblings: Diabetes	3.5	4.4	6.8	1.9	2.0	-2.0	2.6	1.9	2.1	2.1
Smoking status: Previous	0.1	0.2	0.6	-0.4	-0.4	0.8	0.1	-0.1	-0.3	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.2	-0.1	-0.4	0.2	-0.4	-0.1	-0.3	-0.4
Whole body fat-free mass	0.4	2.4	8.9	3.0	-0.1	-2.3	0.9	0.4	1.1	0.4
Leg fat-free mass (right)	0.5	2.4	9.0	3.0	-0.1	-2.1	1.2	0.5	1.2	0.4
Arm fat percentage (left)	1.5	5.8	15.4	3.9	1.0	-3.4	2.6	1.0	1.8	1.4
Average weekly red wine intake	0.7	1.1	3.1	-0.3	-0.5	0.5	-1.7	-0.9	-1.7	-0.5
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.5	-0.0	0.4	0.2	-0.2	0.4	-0.1
Mood swings	0.5	1.0	1.7	-0.4	1.2	-0.1	1.3	1.2	0.8	1.1
Loneliness, isolation	1.0	1.3	2.3	0.4	1.2	-0.6	1.5	1.5	1.3	1.1
Long-standing illness, disability or infirmity	0.6	1.0	2.4	1.2	0.4	-1.3	1.6	-0.6	-0.7	0.5
Ever had bowel cancer screening	0.1	0.1	0.4	0.6	0.1	-0.6	0.3	0.0	-0.1	0.1
Diabetes diagnosed by doctor	4.3	7.0	12.1	3.0	2.6	-2.6	3.5	2.1	1.8	2.7
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	3.9	-1.2	-1.0	0.9	-2.0	-0.4	0.0	-1.1
Friendships satisfaction	1.3	1.6	5.3	-2.3	-0.3	2.2	-0.8	0.4	-0.1	-0.5
Qualifications: nursing, teaching	1.0	1.5	4.9	0.5	-1.2	0.0	-2.2	-1.2	-1.1	-1.1
Commuting to job workplace: Walk	0.2	0.2	1.2	-0.1	0.1	-0.0	-0.1	0.5	1.1	0.1
Eye problems/disorders: Cataract	0.6	0.7	1.6	-0.1	-1.0	0.4	-0.0	-1.3	-1.0	-1.0
Mouth/teeth dental problems: Mouth ulcers	2.6	4.2	6.1	2.5	2.0	-2.5	0.8	1.8	2.1	2.1
Medication for cholesterol	0.2	0.3	2.0	-0.3	-0.1	0.0	-1.4	0.1	-0.4	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.4	-0.7	-0.3	0.5	-0.2	-0.2	-0.5	-0.3
Back pain experienced in last month	0.3	0.4	0.7	0.4	0.8	-0.6	0.5	0.3	0.7	0.8
Mineral and other dietary supplements	0.3	0.4	0.9	0.2	-0.8	0.3	0.5	-1.0	-0.6	-0.8
Breast cancer (self-reported)	1.3	1.5	2.7	1.1	1.6	-1.0	1.1	1.3	0.5	1.6
Asthma (self-reported)	0.5	1.0	2.0	-0.2	-1.4	0.5	-0.4	-1.2	-0.9	-1.3
Osteoporosis (self-reported)	3.0	3.7	5.6	-1.7	-2.4	2.1	-1.3	-2.0	-1.5	-2.3
Osteoarthritis (self-reported)	0.3	0.4	0.7	-0.8	-0.8	0.6	-0.1	-0.8	-0.3	-0.8
Medication: Aspirin	1.5	2.0	5.6	1.4	1.3	-1.1	2.4	1.2	0.7	1.3
Medication: Gliclazide	1.0	1.2	3.8	1.9	0.6	-1.5	1.0	0.3	0.2	0.9
Illnesses of father: None of the above (group 1)	1.3	1.7	2.8	-1.2	-1.5	0.9	-1.7	-1.1	-0.7	-1.6
Smoking status: Current	0.3	0.5	1.2	-0.3	-1.1	0.3	-0.2	-0.9	-0.7	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.6	1.9	1.4	-1.3	1.1	0.8	0.6	1.4
Whole body water mass	0.4	2.0	7.7	2.8	-0.1	-2.1	0.9	0.3	1.0	0.3
Leg predicted mass (right)	0.4	2.3	8.7	3.0	-0.1	-2.1	1.1	0.5	1.2	0.4
Arm fat mass (left)	1.4	5.6	15.4	3.9	0.8	-3.5	2.3	1.0	1.9	1.3
Number of self-reported non-cancer illnesses	0.5	0.8	2.2	1.2	0.6	-0.9	1.5	0.4	-0.1	0.7
Average weekly champagne plus white wine intake	1.3	1.8	5.4	-2.3	-0.5	1.9	-1.4	-0.3	-0.6	-0.9
Miserableness	0.3	0.5	0.8	-0.9	0.6	0.3	0.8	0.9	0.5	0.5
Guilty feelings	1.6	2.5	5.2	-0.1	1.6	-0.6	1.5	2.3	2.1	1.5
Wears glasses or contact lenses	0.1	0.2	0.5	0.2	0.1	0.1	-0.7	0.6	0.4	0.1
Ever taken oral contraceptive pill	2.5	2.8	5.8	-2.4	-1.3	2.2	-1.8	-0.7	-0.5	-1.6
Hearing aid user	6.0	6.8	11.2	3.3	2.5	-3.2	1.4	2.3	2.3	2.7
Mother’s age at death	1.3	1.7	2.1	1.5	1.3	-1.4	1.3	0.9	1.2	1.4
Financial situation satisfaction	0.4	0.5	2.0	-1.4	0.1	0.9	0.9	0.2	-0.1	-0.1
Tinnitus: Yes, now most or all of the time	2.1	2.5	4.0	2.0	1.6	-1.9	0.6	1.6	1.2	1.6
Commuting to job workplace: Public transport	0.3	0.4	1.5	-1.2	-0.2	0.5	0.7	-0.2	-0.5	-0.2
Eye problems/disorders: Glaucoma	3.5	4.2	6.9	1.9	2.2	-1.9	1.5	2.6	1.7	2.2
Medication: Blood pressure	0.2	0.3	1.0	0.4	-0.3	0.2	1.0	-0.7	-0.6	-0.3
Pain type(s) experienced in last month: Hip pain	1.8	2.2	3.4	0.7	1.9	-1.0	1.5	1.5	1.7	1.8
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.7	-0.7	0.6	0.3	-0.8	0.7	-0.1	0.5
High cholesterol (Self-reported)	0.4	0.7	1.3	-0.0	-1.1	-0.0	-1.0	-0.5	1.1	-0.9
Medication: Bendroflumethiazide	0.4	0.6	0.9	0.9	0.8	-0.7	1.0	-0.1	0.3	0.9
Medication: Paracetamol	1.3	2.1	5.2	1.1	1.4	-1.5	2.3	1.0	0.8	1.5
Medication: Lisinopril	0.8	1.0	1.9	1.4	0.7	-1.3	1.2	0.6	0.5	0.9
Medication: Atorvastatin	0.6	0.7	1.6	-0.8	0.2	1.1	-1.1	0.5	1.3	0.0
Illnesses of father: High blood pressure	0.2	0.2	0.9	0.6	-0.0	-0.3	1.0	0.1	0.1	0.1
Alcohol drinker status: Never	0.4	0.5	0.8	0.9	-0.1	-0.7	0.8	-0.9	-0.9	0.1
Ever smoked	0.4	0.7	1.4	-1.1	-0.9	1.2	0.3	-0.3	-0.6	-0.9
Basal metabolic rate	0.5	3.0	10.6	3.2	0.1	-2.6	1.2	0.5	1.3	0.6
Leg fat percentage (left)	2.6	9.4	17.0	4.1	2.1	-4.1	3.3	1.8	2.7	2.4
Arm fat-free mass (left)	0.6	3.0	8.2	2.9	0.4	-2.5	1.5	0.8	1.6	0.8
Number of operations (self-reported)	0.6	0.8	1.7	-1.3	-1.0	0.6	-1.0	-0.8	-0.7	-1.0
Average weekly beer plus cider intake	0.0	0.0	0.2	-0.2	-0.0	0.1	0.5	0.1	-0.0	-0.0
Irritability	1.5	2.6	7.1	1.1	1.3	-1.1	0.7	2.1	2.7	1.4
Risk taking	3.5	5.1	7.0	0.8	2.6	-1.7	2.5	2.5	2.5	2.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.4	-0.5	-0.7	0.8	-1.6	-0.7	-1.4	-0.9
Fractured/broken bones in last 5 years	3.2	4.1	6.8	1.1	1.9	-1.6	2.6	2.5	2.2	1.8
Age started oral contraceptive pill	0.5	0.7	1.4	1.2	0.4	-0.9	-0.0	0.9	1.2	0.5
Diastolic blood pressure, automated reading	0.5	1.5	4.1	0.8	-1.2	-0.6	-0.2	-2.0	-1.7	-0.9
Ever depressed for a whole week	0.1	0.1	0.2	-0.2	-0.3	0.0	0.0	0.4	0.3	-0.3
Unable to work because of sickness or disability	0.1	0.2	0.4	0.4	0.1	-0.7	0.7	0.0	0.3	0.1
Commuting to job workplace: Cycle	2.2	2.7	6.1	0.8	1.7	-1.1	2.5	2.1	0.9	1.6
Myopia	1.5	2.2	3.4	-1.3	-1.6	1.7	-1.9	-1.1	-0.4	-1.7
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.2	0.2	0.6	-0.5	0.2	1.1	0.7	0.5
Cholesterol lowering medication	0.1	0.2	0.3	0.4	-0.5	0.1	0.3	-0.4	0.5	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	-0.3	-0.4	0.2	-0.3	-0.4	-0.8	-0.4
Pain experienced in last month	0.7	1.2	2.3	-0.5	-1.5	1.4	-1.1	-0.8	-0.3	-1.4
Supplements: Calcium	0.1	0.1	0.7	-0.1	-0.1	-0.1	-0.8	0.5	0.1	-0.1
Basal cell carcinoma (self-reported)	0.2	0.3	0.9	-0.1	0.3	0.4	-0.6	0.7	1.0	0.2
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.9	-0.5	-0.7	0.5	-0.5	-1.2	-1.4	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.0	1.4	0.7	-1.0	0.6	0.8	0.1	0.8
Heart disease (siblings)	3.0	3.7	7.8	1.9	1.6	-2.3	2.8	1.2	1.4	1.7
Alcohol drinker status: Previous	0.3	0.3	0.8	0.9	-0.2	-0.6	0.8	-0.4	-0.6	-0.1
Pack years of smoking	0.8	1.2	2.6	1.4	0.7	-1.6	0.9	0.6	1.2	0.9
Impedance of whole body	1.1	5.6	11.9	-3.1	-1.4	2.6	-3.5	-1.2	-2.0	-1.7
Leg fat mass (left)	2.1	8.0	17.9	4.2	1.5	-3.9	3.0	1.4	2.4	1.9
Arm predicted mass (left)	0.6	3.0	8.6	2.9	0.3	-2.6	1.3	0.7	1.7	0.8