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chr7:126,529,931-128,425,768

Best TWAS P=6.31e-15 · Best GWAS P=2.32e-12 conditioned to 0.173

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LRRC4	0.03	0.00	bslmm	387	0.00	8.6e-02	-5.6	6.0	2.2e-09	0.51	0.10	0.30	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SND1	0.08	0.07	lasso	4	0.07	2.2e-08	6.9	-7.0	2.9e-12	-0.97	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	SND1	0.19	0.15	enet	22	0.14	9.8e-12	6.2	-5.4	7.7e-08	-0.68	0.14	0.86	FALSE
4	GTEx	Adipose Visceral Omentum	SND1	0.17	0.15	lasso	3	0.14	6.0e-08	6.5	-7.0	2.9e-12	-0.79	0.11	0.89	FALSE
5	GTEx	Artery Aorta	SND1	0.09	0.10	lasso	3	0.08	2.2e-05	6.7	-7.5	8.5e-14	-0.83	0.06	0.93	FALSE
6	GTEx	Artery Coronary	SND1	0.20	0.26	lasso	1	0.25	6.1e-09	6.7	-6.7	1.9e-11	-0.85	0.03	0.96	FALSE
7	GTEx	Artery Tibial	SND1	0.20	0.23	lasso	5	0.24	4.9e-19	6.5	-6.5	1.0e-10	-0.77	0.19	0.81	FALSE
8	GTEx	Brain Cortex	GCC1	0.22	0.13	lasso	5	0.05	1.9e-02	-5.8	6.4	1.3e-10	0.38	0.20	0.22	FALSE
9	GTEx	Breast Mammary Tissue	SND1	0.22	0.04	lasso	8	0.08	4.5e-05	6.3	-5.4	5.9e-08	-0.67	0.14	0.80	FALSE
10	GTEx	Breast Mammary Tissue (Male)	SND1	0.14	0.06	lasso	3	0.03	7.1e-02	6.7	-6.4	1.5e-10	-0.83	0.07	0.24	FALSE
11	GTEx	Cells Transformed fibroblasts	SND1	0.24	0.21	lasso	7	0.20	4.9e-15	6.3	-6.2	6.4e-10	-0.75	0.21	0.79	FALSE
12	GTEx	Colon Sigmoid	SND1	0.25	0.18	lasso	4	0.16	2.0e-06	6.5	-6.5	7.6e-11	-0.74	0.16	0.84	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	SND1	0.21	0.05	enet	26	0.05	7.9e-03	6.5	-7.8	6.3e-15	-0.54	0.13	0.73	TRUE
14	GTEx	Esophagus Muscularis	SND1	0.17	0.08	lasso	5	0.13	4.8e-08	6.5	-7.2	5.1e-13	-0.68	0.08	0.92	FALSE
15	GTEx	Lung	SND1	0.11	0.00	enet	16	0.03	3.7e-03	6.3	-6.5	6.0e-11	-0.59	0.14	0.65	FALSE
16	GTEx	Muscle Skeletal	SND1	0.05	0.05	lasso	3	0.04	1.0e-04	6.5	-6.7	2.2e-11	-0.84	0.03	0.96	FALSE
17	GTEx	Nerve Tibial	LRRC4	0.07	0.00	lasso	6	0.02	1.3e-02	-2.5	-5.7	1.2e-08	-0.54	0.20	0.65	FALSE
18	GTEx	Nerve Tibial	GCC1	0.09	0.06	lasso	3	0.05	1.7e-04	-5.7	6.3	2.6e-10	0.33	0.41	0.40	FALSE
19	GTEx	Nerve Tibial	SND1	0.23	0.20	lasso	5	0.19	3.0e-13	6.5	-6.8	7.3e-12	-0.76	0.15	0.85	FALSE
20	GTEx	Skin Sun Exposed Lower leg	SND1	0.10	0.08	lasso	4	0.06	1.2e-05	6.0	-6.3	3.4e-10	-0.57	0.43	0.53	FALSE
21	METSIM	Adipose	GCC1	0.05	0.02	bslmm	468	0.02	1.8e-04	-5.8	6.5	1.0e-10	0.43	0.17	0.83	FALSE
22	METSIM	Adipose	SND1	0.06	0.03	blup	602	0.04	1.5e-06	6.2	-7.1	1.2e-12	-0.60	0.11	0.89	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	GCC1	0.05	0.01	enet	18	0.03	1.7e-04	-4.9	5.4	5.9e-08	0.16	0.77	0.13	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	SND1	0.06	0.02	lasso	7	0.02	2.4e-03	6.3	-6.5	6.8e-11	-0.83	0.07	0.92	FALSE
25	YFS	Blood	GCC1	0.03	0.04	lasso	6	0.04	1.8e-12	-5.8	5.7	9.3e-09	0.30	0.60	0.40	FALSE
26	YFS	Blood	SND1	0.03	0.02	lasso	2	0.02	7.8e-08	6.2	-6.3	3.9e-10	-0.78	0.24	0.76	FALSE
27	The Cancer Genome Atlas	Glioblastoma Multiforme	SND1	0.15	0.09	blup	198	0.06	8.7e-03	6.3	-5.7	1.6e-08	-0.66	0.11	0.48	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	GCC1	0.05	0.07	lasso	3	0.06	1.2e-07	-5.7	5.8	6.0e-09	0.33	0.02	0.98	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	SND1	0.09	0.09	lasso	2	0.08	1.8e-09	6.3	-6.5	8.9e-11	-0.76	0.17	0.83	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF800	0.06	0.01	enet	15	0.03	4.9e-04	5.7	-6.1	1.2e-09	-0.28	0.06	0.50	TRUE