[Hub]/) : Traits : Intelligence (Savage-Jansen 2018) :

chr7:126,529,931-128,425,768

Best TWAS P=6.31e-15 · Best GWAS P=2.32e-12 conditioned to 0.173

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex LRRC4 0.03 0.00 bslmm 387 0.00 8.6e-02 -5.6 6.0 2.2e-09 0.51 0.10 0.30 FALSE
2 CommonMind Brain Pre-frontal Cortex SND1 0.08 0.07 lasso 4 0.07 2.2e-08 6.9 -7.0 2.9e-12 -0.97 0.01 0.99 FALSE
3 GTEx Adipose Subcutaneous SND1 0.19 0.15 enet 22 0.14 9.8e-12 6.2 -5.4 7.7e-08 -0.68 0.14 0.86 FALSE
4 GTEx Adipose Visceral Omentum SND1 0.17 0.15 lasso 3 0.14 6.0e-08 6.5 -7.0 2.9e-12 -0.79 0.11 0.89 FALSE
5 GTEx Artery Aorta SND1 0.09 0.10 lasso 3 0.08 2.2e-05 6.7 -7.5 8.5e-14 -0.83 0.06 0.93 FALSE
6 GTEx Artery Coronary SND1 0.20 0.26 lasso 1 0.25 6.1e-09 6.7 -6.7 1.9e-11 -0.85 0.03 0.96 FALSE
7 GTEx Artery Tibial SND1 0.20 0.23 lasso 5 0.24 4.9e-19 6.5 -6.5 1.0e-10 -0.77 0.19 0.81 FALSE
8 GTEx Brain Cortex GCC1 0.22 0.13 lasso 5 0.05 1.9e-02 -5.8 6.4 1.3e-10 0.38 0.20 0.22 FALSE
9 GTEx Breast Mammary Tissue SND1 0.22 0.04 lasso 8 0.08 4.5e-05 6.3 -5.4 5.9e-08 -0.67 0.14 0.80 FALSE
10 GTEx Breast Mammary Tissue (Male) SND1 0.14 0.06 lasso 3 0.03 7.1e-02 6.7 -6.4 1.5e-10 -0.83 0.07 0.24 FALSE
11 GTEx Cells Transformed fibroblasts SND1 0.24 0.21 lasso 7 0.20 4.9e-15 6.3 -6.2 6.4e-10 -0.75 0.21 0.79 FALSE
12 GTEx Colon Sigmoid SND1 0.25 0.18 lasso 4 0.16 2.0e-06 6.5 -6.5 7.6e-11 -0.74 0.16 0.84 FALSE
13 GTEx Esophagus Gastroesophageal Junction SND1 0.21 0.05 enet 26 0.05 7.9e-03 6.5 -7.8 6.3e-15 -0.54 0.13 0.73 TRUE
14 GTEx Esophagus Muscularis SND1 0.17 0.08 lasso 5 0.13 4.8e-08 6.5 -7.2 5.1e-13 -0.68 0.08 0.92 FALSE
15 GTEx Lung SND1 0.11 0.00 enet 16 0.03 3.7e-03 6.3 -6.5 6.0e-11 -0.59 0.14 0.65 FALSE
16 GTEx Muscle Skeletal SND1 0.05 0.05 lasso 3 0.04 1.0e-04 6.5 -6.7 2.2e-11 -0.84 0.03 0.96 FALSE
17 GTEx Nerve Tibial LRRC4 0.07 0.00 lasso 6 0.02 1.3e-02 -2.5 -5.7 1.2e-08 -0.54 0.20 0.65 FALSE
18 GTEx Nerve Tibial GCC1 0.09 0.06 lasso 3 0.05 1.7e-04 -5.7 6.3 2.6e-10 0.33 0.41 0.40 FALSE
19 GTEx Nerve Tibial SND1 0.23 0.20 lasso 5 0.19 3.0e-13 6.5 -6.8 7.3e-12 -0.76 0.15 0.85 FALSE
20 GTEx Skin Sun Exposed Lower leg SND1 0.10 0.08 lasso 4 0.06 1.2e-05 6.0 -6.3 3.4e-10 -0.57 0.43 0.53 FALSE
21 METSIM Adipose GCC1 0.05 0.02 bslmm 468 0.02 1.8e-04 -5.8 6.5 1.0e-10 0.43 0.17 0.83 FALSE
22 METSIM Adipose SND1 0.06 0.03 blup 602 0.04 1.5e-06 6.2 -7.1 1.2e-12 -0.60 0.11 0.89 FALSE
23 ROSMAP Brain Pre-frontal Cortex GCC1 0.05 0.01 enet 18 0.03 1.7e-04 -4.9 5.4 5.9e-08 0.16 0.77 0.13 FALSE
24 ROSMAP Brain Pre-frontal Cortex SND1 0.06 0.02 lasso 7 0.02 2.4e-03 6.3 -6.5 6.8e-11 -0.83 0.07 0.92 FALSE
25 YFS Blood GCC1 0.03 0.04 lasso 6 0.04 1.8e-12 -5.8 5.7 9.3e-09 0.30 0.60 0.40 FALSE
26 YFS Blood SND1 0.03 0.02 lasso 2 0.02 7.8e-08 6.2 -6.3 3.9e-10 -0.78 0.24 0.76 FALSE
27 The Cancer Genome Atlas Glioblastoma Multiforme SND1 0.15 0.09 blup 198 0.06 8.7e-03 6.3 -5.7 1.6e-08 -0.66 0.11 0.48 FALSE
28 The Cancer Genome Atlas Brain Lower Grade Glioma GCC1 0.05 0.07 lasso 3 0.06 1.2e-07 -5.7 5.8 6.0e-09 0.33 0.02 0.98 FALSE
29 The Cancer Genome Atlas Brain Lower Grade Glioma SND1 0.09 0.09 lasso 2 0.08 1.8e-09 6.3 -6.5 8.9e-11 -0.76 0.17 0.83 FALSE
30 The Cancer Genome Atlas Lung Adenocarcinoma ZNF800 0.06 0.01 enet 15 0.03 4.9e-04 5.7 -6.1 1.2e-09 -0.28 0.06 0.50 TRUE