TWAS hub - ZNF800

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.6210	0.0380	0.00000	0.632	0.595	0.626	0.633	0.631	7.0e-100	1.4e-90	2.1e-98	2.9e-100	1.0e-99
2	GTEx	Brain Frontal Cortex BA9	0.2603	0.1015	0.00650	-0.008	NA	-0.006	NA	0.004	6.1e-01	NA	5.0e-01	NA	2.4e-01
3	GTEx	Cells Transformed fibroblasts	0.0980	0.0350	0.00035	0.044	NA	0.052	NA	0.072	3.0e-04	NA	8.7e-05	NA	4.6e-06
4	GTEx	Thyroid	0.0630	0.0260	0.00430	0.000	NA	0.036	NA	0.011	3.3e-01	NA	8.5e-04	NA	4.5e-02
5	TCGA	Brain Lower Grade Glioma	0.0324	0.0172	0.00120	0.036	0.027	0.023	NA	0.031	5.4e-05	4.4e-04	1.1e-03	NA	1.8e-04
6	TCGA	Lung Adenocarcinoma	0.0576	0.0348	0.00079	0.011	0.017	0.026	NA	0.023	1.8e-02	4.3e-03	4.9e-04	NA	8.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Verbal and Numeric Reasoning (VNR)	7.5	18.1	33.1	2.4	-1.3	-4.9	-5.0	-4.3	-5.8
HbA1C	6.7	7.4	12.4	3.4	-1.2	-3.2	-0.2	-3.5	-2.9
Intelligence (Savage-Jansen 2018)	5.5	17.0	37.0	2.0	-0.7	-4.5	-5.0	-3.8	-6.1
Fluid intelligence score	5.4	11.2	20.6	1.8	-0.8	-4.0	-4.0	-3.3	-4.5
Breastfed as a baby	4.6	5.7	12.2	-3.0	0.3	2.4	2.5	3.5	1.0
Smoking status: Previous	4.4	6.5	14.6	-1.0	2.5	3.8	-1.1	2.6	3.1
Ever smoked	4.0	6.9	12.1	-2.1	2.1	3.5	-2.9	3.2	1.4
Past tobacco smoking	3.8	7.1	15.3	1.5	-2.2	-3.9	2.2	-3.2	-2.2
Neuroticism (Nagel 2018)	3.5	8.3	12.8	-3.4	-1.3	2.5	3.6	3.1	2.8
Neuroticism score	3.4	7.0	16.6	-2.4	-0.2	2.4	4.1	3.0	2.3
Smoking Status	3.3	7.8	17.2	-1.9	2.0	4.2	-1.9	3.3	2.8
Average weekly spirits intake	3.3	4.1	9.5	-0.7	3.1	2.7	-1.5	1.9	1.3
Irritability	3.2	5.4	9.4	-2.7	-1.9	1.7	3.1	3.0	0.7
Nervous feelings	3.0	5.7	17.0	-2.1	-0.7	1.1	4.1	3.0	1.4
Worrier / anxious feelings	3.0	5.6	13.5	-3.0	-0.3	0.8	3.2	3.7	0.7
Suffer from ‘nerves’	2.9	4.6	14.2	-1.4	-0.1	1.5	3.8	1.8	2.4
Hearing aid user	2.9	3.2	6.3	-2.3	-0.2	1.9	2.0	0.8	2.5
Guilty feelings	2.8	4.2	10.8	-2.4	-0.2	2.4	1.2	3.3	1.2
Mother’s age at death	2.7	3.4	7.9	0.7	1.3	-1.7	-2.2	-1.6	-2.8
Worry (Nagel 2018)	2.6	5.5	16.6	-2.1	-1.3	0.9	4.1	2.8	1.3
Worry too long after embarrassment	2.6	4.4	14.8	-1.4	1.2	1.1	3.8	2.2	1.5
Illnesses of siblings: Diabetes	2.6	3.2	5.4	-0.9	0.4	2.1	2.1	2.0	2.3
Neuroticism	2.5	6.1	12.5	-1.9	-0.6	2.4	3.5	2.5	2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.2	11.0	-2.0	-1.7	0.4	3.3	0.7	0.6
Loneliness, isolation	2.5	3.4	8.2	-1.3	0.7	1.4	2.9	1.1	2.6
Depressed Affect (Nagel 2018)	2.3	4.9	8.2	-2.6	-1.0	2.5	2.2	1.5	2.9
Relative age of first facial hair	2.3	4.8	16.4	-4.0	-0.5	1.1	1.8	2.6	0.9
Chronic bronchitis/emphysema (father)	2.3	2.7	4.5	0.9	-1.5	-2.1	-1.4	-1.8	-1.7
Alcohol intake versus 10 years previously	2.3	3.5	10.3	1.0	-0.9	-3.2	-0.1	-2.5	-1.6
Number of live births	2.3	3.2	9.5	0.3	-1.1	3.1	0.9	0.3	2.8
Qualifications: College or University degree	2.3	7.3	23.0	-1.0	-0.0	-2.2	-4.8	-0.2	-3.9
Eye problems/disorders: Glaucoma	2.2	2.6	9.5	3.1	1.9	-0.8	-0.7	-1.0	0.8
Fed-up feelings	2.1	3.8	6.6	-2.6	-0.7	2.1	2.2	1.5	2.1
Qualifications: A levels/AS levels or equivalent	2.0	4.4	11.3	-0.1	0.4	-2.0	-3.2	0.2	-3.4
Pulse rate, automated reading	2.0	6.3	13.9	3.5	0.0	-3.7	-0.1	-1.6	-3.1
Alcohol intake frequency.	2.0	4.5	11.4	3.4	-0.4	-2.5	2.5	-1.7	-0.6
Major Depression (MDD)	1.9	2.3	4.7	-1.6	-2.2	-1.4	-0.1	-0.3	-2.1
Average weekly fortified wine intake	1.9	2.3	7.2	2.7	-0.5	-1.6	0.9	-1.6	-0.6
Relative age voice broke	1.9	2.9	6.6	-2.6	-0.9	1.4	1.7	2.0	1.0
Hearing difficulty/problems with background noise	1.9	3.0	5.9	-2.4	-0.7	1.3	2.1	2.4	0.5
Depression (Nagel 2018)	1.8	2.8	9.9	0.5	1.3	2.0	0.4	0.8	3.1
Bipolar Disorder (2011)	1.8	1.7	3.3	0.5	-0.1	-1.5	1.6	-1.4	-1.8
Hand grip strength (left)	1.8	4.8	8.9	0.7	3.0	2.6	-1.7	2.9	1.2
Hand grip strength (right)	1.8	4.9	10.1	0.3	2.8	3.2	-1.4	2.7	1.4
Qualifications: None of the above	1.8	3.9	17.6	0.1	-0.5	1.2	4.2	0.4	2.0
Medication: Ramipril	1.8	2.4	5.2	-0.3	1.2	2.3	1.1	2.1	1.4
Medication: Blood pressure	1.8	3.2	6.9	1.2	2.6	1.3	2.1	1.3	1.7
Average weekly champagne plus white wine intake	1.8	2.5	10.8	0.2	1.2	-0.8	-3.3	0.2	-1.5
Fractured/broken bones in last 5 years	1.8	2.3	8.8	0.7	-1.0	-1.0	-1.3	-3.0	-0.8
Sensitivity / hurt feelings	1.7	2.9	7.5	-1.1	0.3	1.6	2.7	1.8	1.7
Frequency of depressed mood in last 2 weeks	1.7	2.3	7.5	0.0	1.6	1.9	0.4	0.6	2.7
Maternal smoking around birth	1.7	2.4	4.6	0.1	-2.1	-2.1	0.6	-0.8	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	8.1	0.2	1.2	1.6	0.6	1.0	2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.5	7.9	-1.4	-0.9	1.4	2.8	0.6	1.4
Birth weight	1.7	3.7	8.7	-0.8	0.3	1.8	3.0	2.3	2.0
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	8.6	-1.3	0.7	0.9	0.6	2.9	-0.2
Eye problems/disorders: None of the above	1.7	1.9	4.2	-1.8	-1.0	-1.0	1.4	0.6	-2.0
Medication: Lisinopril	1.7	2.2	4.2	2.0	1.7	-1.6	-1.6	-0.8	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	11.6	1.3	3.4	0.2	-1.8	-1.2	2.1
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	5.8	-0.3	-1.9	-0.8	2.4	-0.9	-0.7
Mouth/teeth dental problems	1.6	2.5	5.0	-1.5	1.6	2.2	-0.1	1.2	1.9
Mouth/teeth dental problems: Dentures	1.6	2.7	4.9	1.4	-1.8	-1.7	-0.4	-1.8	-2.2
Prospective memory result	1.6	2.0	5.8	-0.3	-1.1	0.7	2.4	0.3	2.0
Supplements: Vitamin C	1.6	1.8	7.1	-0.0	-2.7	-1.4	1.0	-0.7	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	7.1	-1.6	2.0	2.7	-2.0	1.6	0.5
Heart attack	1.5	1.9	8.5	0.6	-0.1	-1.3	2.9	-0.7	-0.1
Tense / ‘highly strung’	1.5	2.4	7.8	-1.3	-0.6	0.8	2.8	1.9	0.7
Chronic bronchitis/emphysema (mother)	1.5	1.7	5.5	-0.3	-2.3	-1.4	0.6	-1.5	-0.2
Age at first live birth	1.5	2.7	8.5	0.1	1.0	-1.6	-1.9	-0.9	-2.9
Medication: Seretide 50 evohaler	1.5	1.7	4.1	-1.2	0.5	1.3	-1.6	2.0	0.7
Myopia	1.5	2.2	4.3	-1.4	-1.4	-1.6	-1.3	0.7	-2.1
Supplements: Calcium	1.5	1.6	3.5	-1.4	-1.6	0.7	1.9	-0.9	0.9
Heart attack/myocardial infarction (self-reported)	1.5	1.9	8.5	0.5	-0.2	-1.4	2.9	-0.7	-0.1
Schizophrenia (2018)	1.4	3.0	8.0	-1.3	0.0	1.1	2.8	2.6	0.3
Breast Cancer	1.4	3.4	7.4	-0.4	2.4	1.9	0.6	1.7	2.7
Lupus	1.4	2.1	4.6	-1.2	-1.0	1.0	2.1	2.1	0.4
Neuroticism (2016)	1.4	2.0	5.1	-1.5	-0.2	1.1	1.8	2.3	0.2
Diabetes (self-reported)	1.4	2.1	4.9	1.3	2.2	1.0	0.4	0.0	2.2
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	7.7	0.2	2.8	0.6	-2.0	-0.5	2.2
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	3.0	-1.1	0.1	1.6	1.5	1.7	1.6
Noisy workplace	1.3	1.6	4.1	1.5	0.8	-0.8	2.0	-1.4	-0.1
Depression (self-reported)	1.3	1.6	6.0	-1.0	-0.4	1.0	2.4	0.2	1.0
Lung cancer (father)	1.3	1.6	6.7	0.9	0.1	-1.1	2.6	-0.7	-0.3
Health satisfaction	1.3	1.6	4.6	0.4	-2.1	-1.5	0.3	-1.4	-0.9
Medication: Ibuprofen	1.3	1.6	4.5	0.6	0.8	-0.5	-2.1	-1.1	-1.6
Mood swings	1.3	2.4	4.7	-2.2	-1.0	1.3	2.1	1.3	1.0
Eye problems/disorders: Cataract	1.3	1.4	4.3	0.6	-0.0	1.7	-1.1	-0.2	2.1
Breast cancer (self-reported)	1.3	1.5	4.7	0.9	-0.7	1.3	-0.9	0.7	2.2
Basal cell carcinoma (self-reported)	1.3	1.5	4.3	2.1	1.7	0.1	0.6	-1.0	0.6
Bipolar Disorder (2018)	1.2	1.8	5.3	-0.5	0.6	-2.3	0.5	-1.4	-1.7
Rheumatoid Arthritis	1.2	1.6	5.3	-1.1	-0.5	0.4	1.7	2.3	0.4
Qualifications: O levels/GCSEs or equivalent	1.2	1.8	5.8	-1.6	-0.1	-0.2	-2.4	1.2	-1.1
Number of children fathered	1.2	1.3	3.9	1.2	0.6	-0.9	-2.0	-0.7	-1.1
Mean time to correctly identify matches	1.2	2.4	6.1	-0.5	-2.5	-0.1	2.3	1.5	0.3
Heart disease (mother)	1.2	1.5	6.5	0.8	2.5	-0.5	0.7	0.2	1.0
Age at last live birth	1.2	1.7	4.8	-0.8	-0.1	-0.4	-2.2	-0.5	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	5.3	0.8	2.3	-0.1	-0.8	0.4	1.1
Qualifications: nursing, teaching	1.2	1.9	8.5	0.7	1.5	0.3	-2.9	-0.0	0.1
Medication: Atorvastatin	1.2	1.4	4.2	-0.9	0.1	0.9	2.1	1.5	0.6
Reaction Time	1.1	2.2	5.5	0.2	-2.3	-1.1	2.3	1.0	-0.1
Crohns Disease (2012)	1.1	1.8	4.0	1.5	-1.1	-0.8	1.6	-2.0	0.3
Impedance of arm (left)	1.1	5.2	8.9	-1.2	-0.8	-2.5	-2.6	-3.0	-2.7
Length of working week for main job	1.1	1.3	4.3	1.3	-0.2	-0.9	-2.1	-0.7	-0.5
Glaucoma (self-reported)	1.1	1.3	3.1	1.8	1.7	0.1	-1.1	0.1	0.9
Medication: Omeprazole	1.1	1.3	3.2	1.8	0.2	-0.8	-0.8	-1.6	-0.5
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	5.5	-0.6	0.1	-1.4	0.5	0.5	-2.3
Back pain experienced in last month	1.1	1.6	4.7	-0.1	0.3	1.8	-2.2	-0.4	1.1
Wears glasses or contact lenses	1.1	1.3	4.3	-0.4	-1.0	-0.8	-1.0	-0.7	-2.1
Leg fat percentage (left)	1.1	3.9	7.8	2.4	2.8	1.6	1.2	-0.2	2.3
Ever depressed for a whole week	1.1	1.4	6.1	-0.5	-0.2	-0.8	2.5	0.4	-1.1
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	3.7	-0.5	1.9	0.2	-0.9	1.9	-0.2
Ovarian Cancer	1.0	1.3	3.2	-0.4	0.8	1.8	0.1	1.0	1.6
Schizophrenia (2014)	1.0	2.1	4.8	-1.5	-0.2	0.0	2.2	2.0	-1.2
Hypothyroidism (self reported)	1.0	2.4	4.4	-2.1	-1.0	1.7	1.3	1.9	0.6
Diabetes (mother)	1.0	1.3	3.4	0.3	-1.8	0.3	-1.3	-1.6	0.3
Medication: Atenolol	1.0	1.2	3.8	1.9	-0.6	-0.9	1.2	-0.8	0.7
Pain all over the body in last month	1.0	1.1	2.2	-0.1	1.5	1.4	0.6	0.3	1.4
Pulse rate	1.0	1.7	5.6	0.9	-1.0	-1.6	-0.5	-0.2	-2.4
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.6	0.2	0.8	0.9	-1.9	1.4	-0.4
Chest pain or discomfort	1.0	1.5	6.2	1.1	0.4	-2.5	-0.3	-1.0	-0.6
Osteoporosis (self-reported)	1.0	1.2	4.1	-1.3	-2.0	0.2	0.7	-0.3	-0.9
Medication: Omeprazole (e.g. Zanprol)	1.0	1.3	3.7	1.9	-0.7	-0.7	-1.1	-1.2	-0.6
Heel T-Score	0.9	7.2	21.7	3.5	1.3	-2.6	-0.3	-4.7	-0.7
Medication: Metformin	0.9	1.3	4.0	0.9	1.5	0.2	-0.7	-0.0	2.0
Qualifications: CSEs or equivalent	0.9	1.2	3.5	-1.0	0.2	1.9	-0.3	1.5	0.6
Body mass index (BMI)	0.9	3.6	6.4	2.2	2.0	1.2	2.1	0.5	2.5
Waist circumference	0.9	3.1	6.5	2.5	0.5	-0.3	2.5	-1.0	2.2
Impedance of arm (right)	0.9	4.2	8.3	-1.2	-1.0	-2.0	-2.3	-2.9	-2.2
Birth weight of first child	0.9	1.6	5.6	-1.2	-0.3	0.8	2.4	1.3	-0.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	3.6	-1.6	-1.9	-0.9	-0.8	-0.3	-0.9
Leg fat percentage (right)	0.9	3.4	7.2	2.3	2.7	1.4	1.0	-0.4	2.2
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	3.8	1.9	0.8	-0.3	-1.1	0.3	0.5
Age started oral contraceptive pill	0.9	1.1	2.2	0.4	-1.2	-1.5	0.4	-1.2	-1.2
Leg fat mass (left)	0.9	3.5	6.8	2.3	1.9	1.4	1.8	0.2	2.6
Schizophrenia vs Biploar Disorder	0.8	1.1	3.8	-0.7	-1.2	0.5	0.5	1.9	-0.4
Alzheimer’s Disease (in father)	0.8	0.9	1.8	-1.2	-1.0	1.3	0.7	0.4	0.8
Waist Hip Ratio (WHR)	0.8	3.8	8.6	2.5	-0.9	-2.5	-0.3	-2.9	-0.9
Lung FVC	0.8	3.9	9.3	-2.1	0.4	3.0	-0.0	3.0	0.7
Supplements: Zinc	0.8	0.9	1.6	1.2	0.1	-1.3	0.6	-0.8	-1.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.6	-0.6	-0.2	-0.2	1.6	0.1	1.6
Stomach or abdominal pain in last month	0.8	1.0	2.2	-0.8	0.7	1.5	0.5	0.5	1.4
Hair/balding pattern: Pattern 2	0.8	1.0	1.7	-1.3	0.9	0.9	-0.1	1.0	1.3
Had menopause	0.8	1.0	3.8	-0.5	0.3	1.1	1.9	0.6	0.6
Forced vital capacity (FVC)	0.8	3.1	5.4	-2.2	-0.5	2.3	-1.6	2.3	0.2
Happiness	0.8	1.0	3.1	-0.2	-0.8	-1.2	-0.9	-1.8	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.2	-1.5	-0.8	1.4	-0.4	-0.0	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	4.1	-0.2	0.7	-0.3	-2.0	-0.4	-1.1
Medication: Cholesterol lowering	0.8	1.2	4.2	2.0	1.3	0.1	-0.0	-0.6	0.9
Medication: Lansoprazole	0.8	0.9	1.7	1.3	1.3	-0.7	0.5	-1.1	0.5
Exposure to tobacco smoke at home	0.8	0.9	1.7	0.9	1.3	0.8	-0.8	1.1	0.6
Peak expiratory flow (PEF)	0.8	1.9	6.2	1.6	1.5	0.1	-2.5	-0.8	0.1
Pulse wave reflection index	0.8	0.9	2.2	0.3	1.4	0.7	-1.0	-0.0	1.5
Blood clot in the leg (DVT)	0.8	1.0	2.8	-0.4	1.6	-0.1	-0.5	1.7	-0.1
Leg fat mass (right)	0.8	3.1	5.8	2.2	1.9	1.3	1.6	0.2	2.4
Overall health rating	0.8	1.8	3.4	-1.5	1.5	1.8	-0.0	1.2	1.2
Average weekly red wine intake	0.8	1.3	3.1	-1.6	-0.0	1.1	-1.8	0.8	0.3
Medication: Aspirin	0.8	1.0	4.0	0.6	0.2	0.0	2.0	0.1	1.3
Financial situation satisfaction	0.8	1.0	2.2	0.8	-0.2	-1.0	1.0	-1.5	-0.9
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.8	-0.7	1.1	0.7	0.7	1.7	0.3
Heart disease (siblings)	0.8	0.9	3.0	0.7	-0.5	-1.7	0.4	-0.9	-0.9
Bipolar Disorder or Schizophrenia	0.7	1.7	6.2	-1.3	0.4	-0.6	2.5	1.1	-0.8
Crohns Disease (2017)	0.7	1.6	5.5	1.2	0.6	0.6	0.5	-1.3	2.4
Age at First Birth	0.7	1.0	3.8	-1.1	-0.2	0.8	0.2	2.0	-0.4
Coronary Artery Disease (CAD)	0.7	0.8	3.4	-0.1	0.6	-0.7	-0.5	-1.8	-0.5
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	5.1	0.3	-0.1	0.2	2.3	-0.1	0.6
Systolic blood pressure, automated reading	0.7	2.2	8.4	0.7	-0.0	1.5	2.9	1.0	0.9
Medication for hormone replacement therapy	0.7	0.7	1.7	1.3	-0.8	-0.8	1.0	-0.6	0.5
Townsend deprivation index at recruitment	0.7	0.9	4.4	0.1	-0.9	-0.6	2.1	-0.0	-0.1
Serious illness, injury or assault to yourself	0.7	0.8	2.3	1.4	0.1	-0.2	-0.4	-1.5	0.6
Number of incorrect matches in round	0.7	1.1	3.8	-1.4	-0.6	-0.4	1.9	0.4	0.4
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	5.6	-1.6	0.6	2.4	-1.6	1.5	0.9
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.0	1.4	0.0	-0.9	-1.0	-0.9	0.8
Number of full brothers	0.7	0.9	3.8	-0.7	1.9	0.1	0.0	0.8	0.8
Neck or shoulder pain in last month	0.7	1.0	2.3	-1.1	-0.5	1.5	-1.3	0.6	0.5
Had major operations	0.7	0.8	2.0	-0.7	1.4	0.7	-0.4	0.7	1.1
Medication: Gliclazide	0.7	0.8	2.7	1.2	1.6	0.5	-0.4	-0.2	0.7
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.6	0.7	-0.8	-0.6	-0.5	-1.6	-1.0
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.0	1.2	-0.6	0.2	0.7	-0.5	1.7
Medication: Paracetamol	0.7	1.1	2.5	-0.8	1.0	1.0	-1.6	0.6	-0.9
Diastolic blood pressure, automated reading	0.7	2.1	6.8	2.6	-0.9	-0.9	0.9	-1.5	-0.9
Unable to work because of sickness or disability	0.7	0.9	3.2	-0.1	0.4	1.1	1.8	-0.1	0.8
Impedance of whole body	0.7	3.7	7.4	-1.0	0.1	-1.5	-2.5	-2.7	-2.2
Primary Biliary Cirrhosis	0.6	0.9	2.3	0.9	1.4	0.4	-1.5	0.3	0.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.0	-1.4	0.5	-0.9	-0.3	0.2	-1.0
Ulcerative Colitis	0.6	0.9	3.0	-1.7	-0.2	0.9	-0.2	1.2	-0.2
Blood Red Count	0.6	5.9	20.3	4.5	1.2	-2.1	1.4	-2.6	-0.3
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.2	1.5	1.5	0.2	-0.4	-0.8	1.1
Chronotype (morning person)	0.6	1.4	2.5	1.6	-0.5	-1.6	1.2	-0.7	-1.1
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.1	1.4	0.6	-0.6	0.8	-1.0	0.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.6	1.3	0.7	-0.5	0.6	-0.1	1.0
High blood pressure	0.6	1.6	4.2	0.9	1.9	-0.1	2.0	0.8	0.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.4	1.2	1.0	-0.6	-1.1	-0.4	-0.3
High blood pressure (mother)	0.6	0.8	2.3	-0.7	0.6	1.5	0.1	1.0	0.7
Alcohol usually taken with meals	0.6	0.9	1.7	1.3	0.5	1.2	-1.2	-0.3	0.7
Medication: Simvastatin	0.6	0.8	2.2	1.5	1.0	-0.4	-0.4	-1.1	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.3	-0.6	1.3	1.2	0.4	-0.1	1.5
Medication: Paracetamol	0.6	1.0	2.8	-1.3	0.3	0.6	-1.7	0.7	-0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.5	-1.6	-0.7	1.0	1.3	1.2	0.0
Body fat percentage	0.6	2.4	5.1	2.2	2.2	0.6	0.9	-0.9	1.6
Medication: Allopurinol	0.6	0.8	2.7	-0.2	0.0	-0.4	-0.7	-1.6	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.2	-1.0	-1.0	1.1	-0.3	0.7	0.7
Whole body fat mass	0.6	2.6	5.8	2.1	1.7	0.9	1.4	-0.2	2.4
Leg pain on walking	0.6	0.7	1.7	-0.9	0.3	-0.9	0.8	-0.3	-1.3
Medication: Aspirin	0.6	0.7	3.2	0.0	0.2	-0.0	1.8	0.5	1.0
Hypertension (Self-reported)	0.6	1.6	4.5	0.8	2.1	0.1	1.9	0.7	0.7
Number of self-reported non-cancer illnesses	0.6	1.0	5.5	0.3	0.5	0.1	2.3	0.5	0.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.6	-1.3	0.9	1.0	0.4	0.4	0.7
Commuting to job workplace: Public transport	0.6	0.7	2.2	0.3	0.5	-0.2	1.5	1.0	0.9
Medication: Bendroflumethiazide	0.6	0.9	2.4	0.5	1.4	0.1	1.6	0.9	0.4
Illnesses of father: High blood pressure	0.6	0.8	2.9	0.5	1.7	-0.0	-1.0	0.4	0.5
Alcohol drinker status: Never	0.6	0.7	1.6	1.3	0.4	0.2	1.2	-0.0	1.0
Arm fat-free mass (left)	0.6	2.9	7.2	0.7	-0.0	1.7	1.8	1.9	2.7
Risk taking	0.6	0.9	4.9	0.1	0.5	0.6	-2.2	0.2	0.4
Alcohol drinker status: Previous	0.6	0.7	2.9	1.7	-0.4	-0.2	0.5	-0.6	0.4
Arm predicted mass (left)	0.6	3.0	7.1	0.8	-0.4	1.6	2.1	1.7	2.7
Irritable Bowel Disease (IBD)	0.5	1.1	3.6	-0.3	0.7	1.4	0.7	-0.1	1.9
Ulcerative Colitis (UC)	0.5	0.9	1.7	-1.3	0.1	1.3	0.9	1.0	0.4
Prostate Cancer	0.5	0.7	1.8	-0.9	-0.6	0.7	0.8	1.3	0.2
Body Mass Index (BMI) (2010)	0.5	0.6	1.9	0.2	1.4	0.6	0.4	0.7	0.9
Lung FEV1/FVC ratio	0.5	2.7	5.5	2.2	2.4	0.8	-0.3	-1.3	2.0
Hearing difficulty/problems: Yes	0.5	0.8	2.2	-1.5	-0.3	1.5	0.3	0.4	0.4
Medication: Co-codamol	0.5	0.6	2.3	0.1	0.5	-0.6	1.5	-0.5	-0.6
Severe depression (siblings)	0.5	0.6	2.3	0.3	0.5	-0.8	-0.3	-1.5	-0.4
Trunk fat percentage	0.5	2.2	5.1	2.2	1.8	-0.2	0.6	-1.8	1.1
Age when periods started (menarche)	0.5	1.3	5.6	-0.6	0.8	2.4	0.3	0.3	1.0
Trunk fat mass	0.5	2.1	4.9	2.2	1.7	0.2	1.0	-0.9	1.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.7	0.4	-0.7	-1.2	-0.3	-1.3	-0.7
Illnesses of siblings	0.5	0.8	1.3	-0.7	1.1	1.0	-1.0	0.6	0.6
Weight	0.5	2.6	7.3	1.7	1.1	1.0	1.8	0.6	2.7
Arm fat percentage (right)	0.5	1.9	3.8	2.0	1.6	0.4	1.3	-0.6	1.6
Trunk fat-free mass	0.5	2.7	5.7	0.2	-0.7	1.5	1.6	2.2	2.4
Hip circumference	0.5	2.3	7.8	1.3	0.7	1.5	1.4	0.1	2.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	5.0	-1.0	0.5	2.2	-0.9	1.4	1.0
Arm fat mass (right)	0.5	2.1	4.5	2.0	1.4	0.8	1.4	-0.2	2.1
Trunk predicted mass	0.5	2.7	6.0	0.1	-0.7	1.6	1.6	2.2	2.5
Hair/balding pattern: Pattern 4	0.5	1.2	4.5	0.4	-1.0	-0.5	2.1	-0.4	-1.1
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.1	-0.1	-0.8	-0.8	1.4	-0.5	-0.0
Loud music exposure frequency	0.5	0.5	2.0	-0.5	1.4	0.2	0.5	0.8	0.2
Medication: Amlodipine	0.5	0.7	1.6	1.2	1.3	0.1	-0.7	-0.5	-0.4
Arm fat-free mass (right)	0.5	2.5	6.6	1.2	0.0	1.4	1.7	1.6	2.6
Arm predicted mass (right)	0.5	2.7	6.6	1.1	0.1	1.3	1.9	1.7	2.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	4.4	-0.1	-0.8	0.7	-0.3	-0.0	2.1
Arm fat percentage (left)	0.5	1.9	4.4	2.1	1.7	0.1	1.1	-0.8	1.5
Long-standing illness, disability or infirmity	0.5	0.7	1.9	0.5	-0.5	1.4	1.0	0.5	0.9
Diabetes diagnosed by doctor	0.5	0.8	1.5	1.2	1.2	0.2	0.6	-0.2	1.1
Commuting to job workplace: Walk	0.5	0.5	1.1	-0.5	-0.7	0.2	1.0	1.0	0.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	3.4	-0.2	-0.8	0.1	1.8	0.4	0.2
Medication for cholesterol	0.5	0.7	1.7	-0.8	0.4	1.3	-1.1	-0.4	0.5
Smoking status: Current	0.5	0.8	2.2	-0.6	-0.2	0.8	-1.0	1.5	-0.5
Arm fat mass (left)	0.5	2.0	4.1	1.9	1.3	0.5	1.5	-0.2	2.0
Commuting to job workplace: Cycle	0.5	0.7	2.0	0.1	0.6	-0.9	-1.4	-0.2	-0.9
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.8	-1.2	-1.4	0.4	-2.0	-0.4	-0.6
Fasting Glucose	0.4	0.5	1.5	0.7	-0.0	0.7	-1.2	-0.6	-0.3
Triglycerides	0.4	0.6	2.1	0.1	1.4	0.5	-1.0	0.5	0.4
BMI	0.4	2.1	5.0	1.6	2.2	-0.2	1.6	-0.9	1.5
Systolic Blood Pressure	0.4	2.0	3.7	-0.3	1.6	1.6	1.9	1.6	0.8
Number of treatments/medications taken	0.4	0.8	2.1	0.1	0.6	1.2	1.5	0.3	0.9
Diabetes (father)	0.4	0.5	1.8	-0.3	-0.3	-0.7	-0.3	0.4	-1.4
Current tobacco smoking	0.4	0.6	1.5	-0.4	-0.1	0.8	-1.0	1.2	-0.3
Taking other prescription medications	0.4	0.5	2.5	-0.1	-0.8	0.3	1.6	-0.2	0.0
Supplements: Glucosamine	0.4	0.5	1.7	-0.2	-0.2	0.6	0.6	-0.9	1.3
Had other major operations	0.4	0.5	1.1	0.7	0.2	-0.9	1.1	-0.8	-0.4
Father’s age at death	0.4	0.5	1.3	-1.0	-0.6	0.6	-0.3	1.1	0.2
Falls in the last year	0.4	0.5	1.7	0.3	1.3	0.4	-0.8	0.4	0.6
Gout (self-reported)	0.4	0.6	1.4	-0.7	0.3	0.0	-0.8	-1.0	-1.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.2	-0.3	1.0	0.6	-1.1	0.3	0.6
Forced vital capacity (FVC), Best measure	0.4	1.5	2.8	-1.5	-0.6	1.7	-1.1	1.5	0.2
Shortness of breath walking on level ground	0.4	0.5	1.6	-0.8	-1.3	0.3	-0.4	0.5	-0.2
Number of full sisters	0.4	0.5	1.4	0.5	1.2	-0.6	0.7	0.2	-0.7
Family relationship satisfaction	0.4	0.4	1.0	-0.0	-0.9	-1.0	-0.5	-0.8	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.4	1.1	-0.2	-0.2	0.3	-1.2	-0.1
Whole body fat-free mass	0.4	2.5	6.7	0.7	-0.5	1.1	1.8	1.7	2.6
Ever had bowel cancer screening	0.4	0.4	1.5	-0.6	-0.7	0.4	1.2	0.3	-0.1
Osteoarthritis (self-reported)	0.4	0.5	1.6	-1.3	-0.5	0.8	0.4	0.8	0.0
Whole body water mass	0.4	2.3	6.2	0.6	-0.5	1.1	1.6	1.8	2.5
Miserableness	0.4	0.8	1.5	-0.3	0.2	1.1	1.2	0.6	1.2
High cholesterol (Self-reported)	0.4	0.8	1.8	0.6	1.0	0.3	1.4	-0.4	1.0
Basal metabolic rate	0.4	2.3	6.8	0.9	-0.1	1.1	1.7	1.4	2.6
Average weekly beer plus cider intake	0.4	0.6	1.5	-0.2	-1.2	-0.8	0.9	0.1	0.8
Cholesterol lowering medication	0.4	0.5	1.2	0.8	0.6	-1.1	-0.5	-0.9	-0.0
Mean Putamen Volume	0.3	0.3	0.8	-0.3	-0.6	-0.2	0.7	-0.9	0.5
HDL Cholesterol	0.3	0.5	1.1	-0.2	-0.9	0.0	-1.1	-0.2	-0.9
Respiratory disease	0.3	0.6	2.2	-0.5	-1.5	0.3	-0.5	-0.8	-0.2
Ever had hysterectomy (womb removed)	0.3	0.3	1.4	0.2	-0.6	-0.1	1.2	-0.4	0.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.0	0.5	0.2	0.3	-1.0	-0.7	0.4
Angina	0.3	0.4	1.6	1.3	0.2	-0.1	-0.6	-0.6	0.6
Vitamin and mineral supplements	0.3	0.4	1.2	0.7	0.8	0.2	-0.2	-0.2	1.1
Impedance of leg (right)	0.3	1.6	3.3	-0.8	0.6	-0.1	-1.8	-1.6	-1.8
Leg fat-free mass (left)	0.3	1.7	5.5	1.3	-0.4	0.2	1.5	0.6	2.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.7	0.1	1.3	0.9	-0.1	-0.1	1.3
Leg predicted mass (left)	0.3	1.6	5.1	1.4	-0.5	0.1	1.5	0.6	2.3
Financial difficulties in last 2 years	0.3	0.5	0.9	0.3	0.5	0.9	-0.4	-0.8	0.9
Time employed in main current job	0.3	0.4	1.4	-0.2	-0.1	0.2	0.6	0.7	1.2
Pulse wave Arterial Stiffness index	0.3	0.3	1.3	-0.4	0.2	-0.3	1.1	0.2	0.6
Comparative body size at age 10	0.3	0.8	1.6	1.3	0.6	-0.6	-1.2	-0.5	-0.9
Pulse wave peak to peak time	0.3	0.3	0.9	0.3	-0.6	0.1	-0.9	-0.4	-0.5
Angina (self-reported)	0.3	0.4	1.4	1.2	0.2	0.2	-0.4	-0.5	0.7
Migraine (self-reported)	0.3	0.4	1.2	-0.4	-0.7	0.4	-0.3	-0.7	1.1
Comparative height size at age 10	0.3	1.6	5.9	-0.1	-2.4	-1.6	0.5	-0.6	-0.5
Leg fat-free mass (right)	0.3	1.8	5.2	1.3	-0.4	0.1	1.7	0.8	2.3
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.3	1.2	0.2	-0.9	-0.0	-0.1	-0.5
Friendships satisfaction	0.3	0.3	1.6	-0.2	0.1	-0.5	-1.3	0.0	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.6	-0.7	0.1	-0.7	-0.2	0.3	-0.8
Mineral and other dietary supplements	0.3	0.4	0.7	-0.6	0.6	0.4	-0.5	0.9	-0.8
Leg predicted mass (right)	0.3	1.7	4.9	1.3	-0.4	0.1	1.7	0.7	2.2
Medication: Blood pressure	0.3	0.7	1.2	-0.2	0.9	-1.1	1.1	0.5	-0.7
Number of operations (self-reported)	0.3	0.5	1.8	1.3	-0.1	-0.5	0.5	-0.7	0.4
Pain experienced in last month	0.3	0.5	1.4	0.1	0.7	-0.3	-1.2	0.3	-1.0
Alzheimer’s Disease (in mother)	0.2	0.2	1.0	0.0	0.4	0.2	-1.0	0.1	0.4
LDL Cholesterol	0.2	0.3	0.8	0.3	0.9	-0.7	0.2	0.4	-0.2
Blood Eosinophil Count	0.2	1.6	3.2	-0.6	1.3	1.6	-0.1	1.3	1.8
Blood Platelet Count	0.2	1.9	4.7	1.9	0.7	-0.5	1.6	-2.2	0.1
Cardiovascular Disease	0.2	0.8	1.3	0.8	1.0	-1.0	0.4	-1.1	-0.7
Medication: Levothyroxine sodium	0.2	0.3	0.9	-0.1	-0.7	-0.3	0.9	-0.6	-0.2
Sitting height	0.2	1.2	4.9	-0.7	-1.3	-0.5	-2.2	-0.3	-0.3
Impedance of leg (left)	0.2	1.2	2.1	-0.8	0.7	0.2	-1.4	-1.3	-1.4
Allergy	0.2	0.5	1.1	0.3	-1.0	-0.8	0.3	-0.1	-1.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.9	0.6	0.3	-0.1	0.8	0.3
Asthma	0.2	0.4	1.1	-0.5	0.2	0.2	-1.0	-0.8	-0.1
Illnesses of mother	0.2	0.3	0.8	-0.3	-0.3	0.1	0.3	0.9	-0.9
Headache pain in last month	0.2	0.3	1.2	0.3	-0.4	0.3	0.3	0.3	1.1
Exposure to tobacco smoke outside home	0.2	0.2	0.8	-0.0	0.1	-0.9	-0.2	-0.6	0.2
Emphysema/chronic bronchitis	0.2	0.2	1.0	-0.2	-0.2	0.1	0.1	0.1	1.0
Medication for pain relief, constipation, heartburn	0.2	0.3	1.0	0.2	-0.9	0.0	1.0	-0.3	0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.8	-0.0	0.0	0.4	-0.9	0.0	-0.3
Illnesses of father: None of the above (group 1)	0.2	0.2	0.9	0.2	0.3	0.0	0.9	-0.1	0.6
Pack years of smoking	0.2	0.2	0.7	-0.0	-0.8	0.1	0.7	-0.2	0.5
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	-0.3	-0.3	0.2	-0.7	0.4	0.0
Blood White Count	0.1	0.4	1.8	-0.2	1.4	0.2	-0.1	-0.6	0.2
Height	0.1	2.1	6.6	-1.3	-2.6	0.7	-0.8	1.7	0.5
Allergy or Eczema	0.1	0.3	0.6	0.1	0.6	0.6	-0.8	-0.6	0.4
Hair Pigment	0.1	1.7	3.6	-0.6	1.9	1.1	-1.4	1.4	1.2
Tanning	0.1	0.8	2.9	-0.6	-0.4	-0.1	0.9	0.7	-1.7
Pack years adult smoking proportion	0.1	0.2	0.5	0.0	-0.7	0.1	0.6	-0.2	0.5
Multivitamins +/- minerals	0.1	0.1	0.3	-0.1	0.2	0.3	-0.3	0.5	-0.4
Standing height	0.1	0.7	3.1	-0.6	-1.8	-0.6	-0.4	-0.0	0.3
High blood pressure (siblings)	0.1	0.2	0.5	-0.3	-0.4	0.2	0.7	0.3	-0.5
Wheeze or whistling in the chest in last year	0.1	0.3	1.1	-0.4	-0.3	0.3	-0.1	-0.2	1.0
Knee pain experienced in last month	0.1	0.1	0.4	-0.4	-0.2	-0.1	0.0	-0.3	-0.6
Illnesses of father: Heart disease	0.1	0.2	0.4	0.6	0.3	-0.1	0.3	0.3	0.6
Asthma (self-reported)	0.1	0.2	0.7	-0.3	0.3	0.1	-0.6	-0.8	0.1
Ever taken oral contraceptive pill	0.1	0.2	0.4	0.6	-0.3	-0.2	-0.2	-0.6	-0.1

Hub : Genes

ZNF800

Models

Trait associations