[Hub]/) : Traits : Intelligence (Savage-Jansen 2018) :

chr10:64,195,778-66,034,105

Best TWAS P=2.33e-11 · Best GWAS P=2.88e-10 conditioned to 0.288

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex REEP3 0.05 0.05 lasso 3 0.04 5.9e-06 5.4 5.4 5.9e-08 0.71 0.23 0.77 FALSE
2 GTEx Brain Frontal Cortex BA9 NRBF2 0.25 0.17 lasso 6 0.16 6.1e-05 5.2 -5.3 1.4e-07 -0.71 0.13 0.77 FALSE
3 GTEx Esophagus Muscularis NRBF2 0.10 0.03 enet 22 0.03 3.8e-03 6.3 -5.2 2.2e-07 -0.77 0.01 0.97 FALSE
4 GTEx Nerve Tibial NRBF2 0.08 0.09 enet 11 0.06 5.0e-05 5.2 -5.3 1.4e-07 -0.71 0.19 0.80 FALSE
5 GTEx Testis NRBF2 0.14 0.08 lasso 12 0.09 6.7e-05 5.2 -5.3 1.3e-07 -0.75 0.08 0.90 FALSE
6 GTEx Testis JMJD1C-AS1 0.22 0.08 enet 23 0.10 3.7e-05 -4.7 -5.2 1.6e-07 -0.33 0.63 0.10 FALSE
7 ROSMAP Brain Pre-frontal Cortex NRBF2 0.34 0.46 lasso 5 0.46 3.1e-66 5.2 -5.2 2.0e-07 -0.71 0.21 0.79 FALSE
8 The Cancer Genome Atlas Breast Invasive Carcinoma NRBF2 0.05 0.06 lasso 2 0.06 5.5e-12 5.2 -5.3 9.1e-08 -0.74 0.25 0.75 FALSE
9 The Cancer Genome Atlas Glioblastoma Multiforme JMJD1C 0.11 0.02 blup 87 0.05 1.4e-02 5.4 -5.9 3.1e-09 -0.68 0.03 0.40 FALSE
10 The Cancer Genome Atlas Glioblastoma Multiforme NRBF2 0.17 0.09 enet 10 0.13 1.1e-04 5.2 -5.5 3.1e-08 -0.67 0.05 0.57 FALSE
11 The Cancer Genome Atlas Brain Lower Grade Glioma NRBF2 0.08 0.08 enet 6 0.08 4.3e-09 5.2 -5.3 1.1e-07 -0.78 0.15 0.85 FALSE
12 The Cancer Genome Atlas Pancreatic Adenocarcinoma LOC84989 0.10 0.05 blup 19 0.04 7.7e-03 -4.8 -5.3 1.5e-07 -0.52 0.01 0.39 FALSE
13 The Cancer Genome Atlas Pancreatic Adenocarcinoma NRBF2 0.18 0.13 enet 11 0.08 2.5e-04 5.4 -5.8 5.7e-09 -0.82 0.01 0.96 FALSE
14 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma NRBF2 0.08 0.02 blup 40 0.04 8.6e-03 5.2 -5.3 9.8e-08 -0.63 0.02 0.24 FALSE
15 The Cancer Genome Atlas Prostate Adenocarcinoma NRBF2 0.08 0.09 lasso 6 0.08 9.7e-09 5.4 -5.2 1.9e-07 -0.72 0.20 0.80 FALSE
16 The Cancer Genome Atlas Thyroid Carcinoma NRBF2 0.14 0.10 enet 16 0.09 8.1e-09 5.4 -6.7 2.3e-11 -0.86 0.03 0.97 TRUE