TWAS hub - ACTR1A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0260	0.0140	8.9e-03	0.007	0.006	0.005	0.006	0.001	4.7e-02	5.6e-02	7.7e-02	5.7e-02	2.1e-01
2	GTEx	Cells EBV-transformed lymphocytes	0.2240	0.0780	3.8e-05	0.182	NA	0.147	NA	0.191	1.5e-06	NA	1.6e-05	NA	8.0e-07
3	GTEx	Liver	0.1510	0.0760	6.4e-03	0.005	NA	-0.010	NA	-0.005	2.3e-01	NA	7.8e-01	NA	4.6e-01
4	GTEx	Skin Sun Exposed Lower leg	0.0760	0.0330	4.2e-04	0.057	NA	0.068	NA	0.054	1.6e-05	NA	2.7e-06	NA	3.0e-05
5	NTR	Blood	0.0272	0.0102	2.4e-07	0.027	0.027	0.028	0.028	0.027	3.8e-09	3.4e-09	1.4e-09	1.8e-09	2.9e-09
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0242	0.0160	3.8e-03	0.020	0.016	0.008	NA	0.017	2.4e-03	5.4e-03	3.6e-02	NA	4.6e-03
7	TCGA	Brain Lower Grade Glioma	0.0356	0.0225	4.4e-03	0.013	0.025	0.002	NA	0.015	1.2e-02	7.1e-04	1.8e-01	NA	6.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Smoking Status	15.4	36.9	94.7	7.6	5.4	-9.7	5.7	5.3	3.5	-1.7
Past tobacco smoking	15.4	28.3	49.8	-5.5	-4.9	7.1	-5.6	-5.5	-4.4	3.6
Allergy or Eczema	14.0	37.0	62.9	-6.5	-5.2	2.4	-6.2	-7.9	-7.6	4.9
Hayfever, allergic rhinitis or eczema	11.7	25.4	43.7	-5.4	-4.3	1.7	-5.0	-6.6	-6.4	4.2
Height	11.3	217.3	338.6	15.4	16.1	-3.5	14.7	18.4	17.5	-12.3
Standing height	11.3	112.6	182.2	11.8	11.4	-2.1	9.9	13.5	12.4	-9.0
Ever smoked	11.3	19.8	39.2	5.1	3.9	-6.3	3.7	4.6	3.6	-3.4
Forced expiratory volume in 1-second (FEV1), predicted	10.8	22.5	40.1	5.7	4.7	-2.1	3.5	6.3	5.4	-4.2
Allergy	10.7	24.5	45.3	5.5	4.4	-1.0	4.1	6.7	6.4	-4.1
Worrier / anxious feelings	10.4	19.6	33.8	-5.2	-5.7	5.8	-3.6	-4.4	-2.8	2.0
Hand grip strength (left)	9.5	25.0	49.4	3.7	4.8	-7.0	6.7	5.4	3.8	-0.5
Prostate Cancer	9.2	12.9	17.7	-3.9	-4.0	2.5	-3.2	-4.2	-4.2	2.8
Sitting height	9.2	65.5	106.1	7.7	8.8	-1.3	8.0	10.3	10.3	-6.7
Hearing difficulty/problems with background noise	8.8	14.1	22.5	4.6	3.3	-0.0	3.3	4.4	4.7	-3.6
Maternal smoking around birth	8.6	12.4	43.6	3.3	2.8	-6.6	3.6	2.9	1.8	-0.6
Comparative height size at age 10	8.3	45.8	74.6	6.9	7.1	-2.4	6.8	8.6	8.3	-5.3
Smoking status: Current	8.0	12.8	34.1	4.7	3.2	-5.8	3.4	2.9	1.8	-0.1
Ulcerative Colitis	7.6	11.1	20.1	2.8	2.7	-1.1	2.7	4.1	4.5	-4.1
Current tobacco smoking	7.4	12.1	29.7	4.7	3.3	-5.5	3.2	2.9	1.8	-0.3
Pulse wave peak to peak time	7.4	8.7	20.2	4.5	3.0	-1.0	2.1	3.9	2.6	-2.0
Smoking status: Previous	7.1	10.6	16.0	3.2	2.6	-4.0	3.4	3.5	2.9	-3.0
Worry (Nagel 2018)	6.9	14.5	30.0	-4.6	-5.2	5.5	-2.3	-3.5	-2.1	1.4
Trunk fat-free mass	6.9	39.4	56.4	7.2	7.3	-6.7	6.1	7.5	5.6	-1.4
Trunk predicted mass	6.8	38.6	55.1	7.2	7.2	-6.7	6.0	7.4	5.5	-1.3
Hand grip strength (right)	6.7	18.3	44.9	3.2	3.4	-6.7	5.4	4.7	3.2	-0.3
Reaction Time	6.2	11.8	18.2	-3.8	-3.3	3.0	-3.6	-4.3	-3.7	1.8
Arm fat-free mass (right)	5.8	29.7	46.2	6.3	6.2	-6.8	5.3	6.1	4.3	-0.4
Arm predicted mass (right)	5.8	29.6	45.2	6.4	6.2	-6.7	5.1	6.1	4.3	-0.5
Schizophrenia (2018)	5.7	11.8	33.0	-3.0	-4.8	5.7	-2.9	-2.1	0.0	-2.0
Exposure to tobacco smoke outside home	5.6	7.5	17.0	4.0	2.5	-4.1	2.0	2.7	1.5	-0.6
Whole body fat-free mass	5.6	31.8	46.9	6.5	6.8	-6.6	5.3	6.4	4.3	-0.2
Arm predicted mass (left)	5.6	28.6	42.8	6.1	6.4	-6.5	5.2	5.9	4.1	-0.1
Schizophrenia (2014)	5.5	12.2	31.5	-3.4	-4.6	5.6	-3.1	-2.4	0.1	-2.2
Whole body water mass	5.5	31.1	45.8	6.5	6.8	-6.6	5.3	6.3	4.3	-0.2
Arm fat-free mass (left)	5.5	28.0	43.0	5.9	6.4	-6.6	5.2	5.9	4.0	-0.1
Length of working week for main job	5.3	5.9	10.5	1.8	1.9	-2.4	2.1	3.2	2.6	-2.6
Bipolar Disorder or Schizophrenia	5.1	12.3	37.7	-2.8	-4.6	6.1	-3.0	-1.8	0.7	-2.8
Basal metabolic rate	5.1	28.4	42.8	6.3	6.5	-6.3	5.0	5.9	4.0	0.0
Peak expiratory flow (PEF)	4.9	11.3	18.5	4.3	3.3	-3.9	2.9	4.3	2.7	-0.5
Hearing difficulty/problems: Yes	4.8	7.4	13.1	2.9	2.2	0.5	2.8	3.1	3.6	-2.8
Nervous feelings	4.8	8.9	27.7	-3.4	-3.6	5.3	-2.0	-2.2	-1.1	-0.2
Blood White Count	4.6	33.9	45.3	6.1	4.2	-5.2	4.7	6.7	6.7	-6.5
Birth weight of first child	4.6	8.3	18.0	4.0	4.2	-1.8	2.5	3.5	1.7	0.4
Qualifications: A levels/AS levels or equivalent	4.4	9.6	23.4	2.4	2.3	4.8	0.6	2.8	3.5	-3.6
Pulse wave Arterial Stiffness index	4.3	5.0	14.7	-3.8	-2.2	0.8	-1.4	-3.0	-1.6	1.1
Bilateral oophorectomy (both ovaries removed)	4.2	4.9	6.0	-2.2	-2.4	2.4	-2.5	-2.4	-2.2	1.4
Medication: Atenolol	4.2	5.2	12.8	2.0	1.1	-0.1	1.0	2.8	3.1	-3.6
Pain type(s) experienced in last month: Hip pain	4.2	5.3	9.2	-1.7	-2.5	-1.4	-1.6	-3.0	-2.7	2.5
Leg fat-free mass (left)	4.1	21.9	39.0	5.5	5.9	-6.2	4.2	4.9	2.8	0.9
Leg predicted mass (left)	4.1	21.8	38.4	5.5	5.9	-6.2	4.1	4.9	2.8	0.8
Forced vital capacity (FVC)	4.1	15.9	28.4	4.3	4.1	-2.4	2.5	5.3	4.8	-3.5
Hayfever/allergic rhinitis (self-reported)	4.1	5.4	10.4	-2.2	-2.1	0.7	-2.0	-3.2	-3.2	1.9
Leg fat-free mass (right)	4.1	21.9	37.6	5.6	6.1	-5.8	4.1	5.0	2.8	0.9
Leg predicted mass (right)	4.1	22.1	37.4	5.6	6.1	-5.9	4.2	5.0	2.8	0.9
Crohns Disease (2012)	3.9	6.2	9.3	2.8	2.5	-1.2	2.4	2.8	3.0	-2.4
Birth weight	3.9	8.5	17.3	3.7	4.2	-2.7	2.6	3.1	2.0	-0.6
Mean Putamen Volume	3.8	4.4	8.9	0.9	3.0	0.2	2.5	2.1	2.7	-1.7
Neuroticism	3.8	9.2	15.9	-3.6	-4.0	3.5	-1.7	-3.4	-2.4	1.7
Weight	3.8	18.5	29.7	5.4	5.4	-5.2	4.0	4.4	2.7	0.8
Number of incorrect matches in round	3.6	6.0	20.8	-4.6	-3.3	0.7	-0.8	-2.5	-1.6	0.8
Mineral and other dietary supplements	3.6	4.8	14.7	-1.5	-1.9	3.8	-2.5	-2.0	-1.6	0.4
Financial situation satisfaction	3.6	4.5	11.3	3.4	2.4	-1.7	1.9	2.1	1.7	0.2
Diabetes (mother)	3.5	4.4	7.2	2.4	2.3	-0.6	2.3	2.7	2.0	-1.8
Blood Platelet Count	3.3	38.4	65.9	5.6	6.2	-2.9	5.5	6.5	7.1	-8.1
Ulcerative Colitis (UC)	3.2	5.9	10.8	2.0	2.1	-0.1	2.1	2.9	3.3	-2.9
Alcohol usually taken with meals	3.1	5.1	23.0	-1.0	-1.6	4.8	-3.0	-0.2	-0.1	-0.3
Asthma	3.1	6.1	12.0	-2.9	-1.4	-1.6	-0.2	-3.5	-3.2	2.7
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	9.6	1.1	1.8	-3.1	2.5	0.9	0.8	-0.6
Supplements: Zinc	2.9	3.1	7.1	1.4	1.8	-2.7	2.0	1.7	1.6	-0.5
Townsend deprivation index at recruitment	2.9	4.1	14.0	2.5	1.7	-3.7	2.1	1.2	0.4	-0.0
Forced vital capacity (FVC), Best measure	2.9	10.4	19.3	3.7	3.3	-1.9	1.8	4.4	3.9	-2.7
Qualifications: College or University degree	2.9	9.1	40.6	-0.0	-0.3	6.4	-3.0	0.2	1.8	-3.3
Asthma (self-reported)	2.9	5.8	11.9	-3.1	-1.5	-1.6	-0.1	-3.5	-3.0	2.4
Intelligence (Savage-Jansen 2018)	2.8	8.7	28.1	3.1	2.5	5.3	-0.8	1.9	2.4	-2.7
Neuroticism (Nagel 2018)	2.8	6.7	11.5	-3.3	-3.4	3.2	-0.6	-2.8	-1.7	1.7
Neuroticism score	2.8	5.8	11.5	-2.7	-3.4	2.5	-1.6	-2.7	-2.0	1.3
Bipolar Disorder (2011)	2.7	2.6	6.9	0.2	-1.6	2.0	-0.5	1.1	1.8	-2.6
Medication: Ibuprofen (e.g. Nurofen)	2.7	3.4	5.5	-2.4	-2.3	0.0	-1.6	-2.1	-1.8	1.5
Worry too long after embarrassment	2.7	4.5	9.7	-2.1	-2.2	3.1	-1.7	-2.3	-2.0	1.1
Irritable Bowel Disease (IBD)	2.6	6.3	11.0	1.9	2.0	-0.9	2.4	2.8	3.3	-3.3
Neuroticism (2016)	2.6	3.7	6.5	-2.4	-1.5	2.3	-1.5	-2.5	-1.6	1.1
Forced expiratory volume in 1-second (FEV1)	2.6	8.8	16.1	3.1	2.8	-3.4	1.6	4.0	3.3	-1.7
Pulse rate	2.6	4.3	9.4	-3.1	-2.2	0.8	-1.8	-2.8	-1.7	1.3
Verbal and Numeric Reasoning (VNR)	2.5	5.9	11.5	3.4	2.7	3.4	-1.0	1.9	1.8	-1.9
Coronary Artery Disease (CAD)	2.5	3.0	5.1	-2.0	-2.3	2.3	-1.5	-0.8	0.6	-1.8
Waist Hip Ratio (WHR)	2.4	10.9	17.7	2.1	2.3	1.8	3.9	3.8	4.2	-4.1
Respiratory disease	2.4	5.4	10.5	-3.0	-2.0	-0.8	-0.7	-3.2	-3.0	1.9
Fractured/broken bones in last 5 years	2.4	3.2	5.6	-1.7	-2.4	0.7	-2.3	-2.2	-1.8	0.2
Impedance of whole body	2.4	12.2	51.8	-0.1	-1.2	7.2	-0.5	0.6	2.3	-5.1
Vitamin and mineral supplements	2.3	3.1	11.2	-1.3	-1.7	3.4	-1.5	-1.6	-0.9	0.6
Mouth/teeth dental problems: Dentures	2.3	3.8	10.1	2.1	2.2	-3.2	2.2	1.3	0.4	0.8
Impedance of arm (left)	2.3	10.6	51.1	-0.6	-1.4	7.2	-1.3	-0.2	1.3	-4.2
Blood clot in the leg (DVT)	2.3	3.0	5.0	-2.0	-2.2	1.2	-1.4	-2.1	-1.6	1.3
Ever had bowel cancer screening	2.3	2.7	4.2	1.4	2.1	0.1	2.0	1.7	1.9	-1.5
Deep venous thrombosis (DVT) (self-reported)	2.3	3.0	5.8	-2.1	-2.4	1.2	-1.4	-2.0	-1.5	1.1
Schizophrenia vs Biploar Disorder	2.2	2.9	6.7	-2.6	-2.1	1.3	-1.3	-2.0	-1.1	0.6
BMI	2.2	12.5	47.6	1.0	1.6	-4.7	-0.2	-1.4	-3.6	6.9
Systolic Blood Pressure	2.2	11.2	34.3	-3.4	-5.9	4.5	-1.9	-2.5	-0.4	-1.6
Impedance of leg (right)	2.2	10.9	32.8	0.3	-1.1	5.2	0.7	1.6	3.5	-5.7
Impedance of leg (left)	2.2	10.8	29.5	0.8	-0.6	5.4	0.9	1.8	3.4	-5.4
Chronic bronchitis/emphysema (mother)	2.2	2.5	4.2	1.8	0.5	-1.9	2.0	2.1	1.5	-0.5
Friendships satisfaction	2.2	2.7	9.4	0.4	-0.1	3.1	-1.5	-1.1	-1.2	2.1
Qualifications: nursing, teaching	2.2	3.4	11.1	0.2	0.9	3.3	0.7	1.2	2.3	-2.1
Systolic blood pressure, automated reading	2.1	6.2	19.4	-2.3	-4.4	2.7	-1.9	-2.6	-1.0	-0.1
Severe depression (siblings)	2.1	2.3	4.6	-0.8	-1.8	1.7	-2.1	-1.7	-1.3	-0.2
Had menopause	2.1	2.6	5.5	-2.0	-1.8	1.4	-1.4	-2.4	-1.2	0.4
Qualifications: None of the above	2.1	4.5	20.2	0.2	1.1	-4.5	2.3	0.2	-0.7	2.1
Diabetes (self-reported)	2.1	3.3	8.8	1.6	3.0	-1.9	2.2	1.7	0.8	0.1
Impedance of arm (right)	2.1	9.7	46.2	-0.5	-0.6	6.8	-0.7	0.2	1.6	-4.2
Hip circumference	2.1	9.1	22.3	3.6	3.9	-4.7	2.3	2.0	0.7	1.8
Lung cancer (father)	2.1	2.5	4.7	1.7	1.6	-0.1	1.6	1.9	2.2	-1.1
Pulse wave reflection index	2.1	2.6	4.5	2.1	2.1	-2.1	1.6	1.4	0.8	0.4
Medication: Aspirin	2.1	2.8	6.4	1.1	1.5	1.0	0.0	1.8	2.5	-2.4
Diabetes diagnosed by doctor	2.1	3.5	9.5	1.7	3.1	-1.9	2.4	1.5	0.5	0.4
Medication: Aspirin	2.1	2.8	6.3	1.0	1.5	0.8	0.6	1.7	2.5	-2.4
Fasting Glucose	2.0	2.4	6.3	1.0	2.5	-2.0	1.7	1.5	0.1	-0.3
Type 2 Diabetes (T2D) (2018)	2.0	3.7	11.9	2.2	3.5	-1.3	1.8	1.9	0.9	-0.1
Relative age of first facial hair	2.0	4.1	5.8	2.4	1.8	-1.8	1.9	2.4	2.1	-1.9
Body mass index (BMI)	2.0	8.4	24.8	0.2	0.4	-4.7	-0.3	-1.6	-2.9	5.0
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.5	13.6	0.8	0.2	2.4	0.8	2.1	2.5	-3.7
Mean time to correctly identify matches	2.0	3.9	7.1	-2.1	-1.4	2.7	-2.0	-2.5	-1.7	0.2
Leg fat mass (right)	2.0	7.8	23.1	3.0	3.0	-4.8	2.4	1.8	0.7	1.9
Knee pain experienced in last month	2.0	3.0	13.6	0.8	1.0	-3.7	1.8	0.9	1.0	-0.8
Basal cell carcinoma (self-reported)	2.0	2.4	6.6	0.4	0.6	-0.4	1.3	1.5	2.6	-2.3
Ever had hysterectomy (womb removed)	1.9	2.2	4.4	-1.8	-2.1	1.2	-0.7	-1.4	-1.5	1.2
Age when periods started (menarche)	1.9	4.6	9.0	2.0	1.9	-3.0	1.7	2.4	1.6	-2.0
High blood pressure (mother)	1.9	2.6	7.2	-0.9	-2.7	1.5	-2.4	-1.3	-0.7	0.6
Waist circumference	1.9	7.0	11.2	3.3	3.3	-3.2	3.0	2.2	1.2	1.1
Fluid intelligence score	1.9	4.0	8.3	2.9	1.5	2.9	-0.8	1.8	1.6	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.1	12.1	2.8	2.2	-2.8	1.0	3.5	2.7	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.4	4.7	-1.9	-1.4	1.8	-0.1	-2.2	-1.4	1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	3.3	1.6	1.1	0.2	1.7	1.5	1.8	-1.8
Shortness of breath walking on level ground	1.9	2.2	4.2	-1.5	-1.3	-0.8	-0.8	-1.9	-1.7	2.0
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	12.3	0.3	-0.1	-3.5	0.7	1.1	0.9	-1.2
Supplements: Vitamin C	1.9	2.2	7.6	-0.0	1.8	-2.7	2.0	0.7	0.7	-0.1
Risk taking	1.9	2.7	7.5	2.6	1.0	-2.7	0.1	1.2	0.9	-1.2
Leg fat mass (left)	1.9	7.5	20.6	3.1	3.0	-4.5	2.3	1.7	0.5	2.1
Medication: Paracetamol	1.8	3.0	9.3	-2.4	-3.0	-1.2	-0.4	-1.9	-1.0	-0.0
Pack years of smoking	1.8	2.6	7.8	2.7	1.0	-2.8	1.1	0.9	0.5	-0.0
Pack years adult smoking proportion	1.7	2.5	8.0	2.7	0.8	-2.8	0.9	0.8	0.3	0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.8	12.7	0.5	-0.4	2.5	0.3	1.8	1.9	-3.6
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	6.9	1.3	1.8	-2.6	2.1	1.3	1.1	-0.4
Medication: Ventolin 100micrograms inhaler	1.7	2.2	5.5	-2.4	-0.5	-0.6	0.6	-2.0	-1.7	1.5
Mouth/teeth dental problems: Loose teeth	1.7	2.0	6.0	-0.3	1.8	-2.0	2.5	-0.0	-0.1	0.7
Migraine (self-reported)	1.7	2.1	6.2	1.2	2.2	-2.5	0.7	1.1	0.4	0.5
Commuting to job workplace: Walk	1.7	1.8	3.8	-0.9	-1.5	2.0	-1.8	-0.6	-0.4	-1.5
Medication: Bendroflumethiazide	1.7	2.6	4.7	1.3	1.3	-0.5	2.2	1.5	2.1	-1.8
Father’s age at death	1.6	2.1	8.2	0.7	0.6	2.9	0.1	1.3	1.7	-1.2
Suffer from ‘nerves’	1.6	2.4	10.7	-1.3	-1.9	3.3	-0.3	-0.9	-0.2	-0.4
Average weekly champagne plus white wine intake	1.6	2.2	4.4	0.2	0.0	2.1	-1.4	-1.3	-2.0	1.9
Supplements: Fish oil (including cod liver oil)	1.6	2.1	8.3	0.8	0.7	-2.9	1.3	1.3	1.1	-0.6
Body Mass Index (BMI) (2010)	1.5	2.1	5.3	1.4	1.1	-2.3	-0.2	-0.1	-1.2	2.1
Cardiovascular Disease	1.5	4.8	11.3	1.5	0.5	1.8	1.6	2.1	3.2	-3.4
Ever used hormone-replacement therapy (HRT)	1.5	1.9	6.9	-2.6	-0.9	0.1	0.4	-1.8	-1.1	0.9
Chronic bronchitis/emphysema (father)	1.5	1.8	4.3	-1.5	-1.3	-0.4	-0.1	-2.1	-1.7	0.9
Trunk fat mass	1.5	6.3	11.1	3.1	3.3	-3.2	2.6	2.0	1.1	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	3.9	-1.1	-1.8	1.9	-1.6	-2.0	-1.3	0.8
Alcohol intake versus 10 years previously	1.5	2.2	9.6	3.1	0.7	-1.8	0.2	1.3	0.3	0.7
Commuting to job workplace: Car/motor vehicle	1.5	1.8	8.5	-0.1	0.8	-2.9	0.8	-0.5	-0.8	1.3
Average weekly red wine intake	1.5	2.2	7.5	-0.6	-1.2	2.7	-1.1	0.6	0.8	-1.8
Mother’s age at death	1.5	1.9	3.5	0.9	1.4	1.5	1.1	1.9	1.5	-1.1
Bipolar Disorder (2018)	1.4	2.2	7.0	-0.7	-1.3	2.7	-1.1	-0.2	1.1	-1.9
Serious illness, injury or assault to yourself	1.4	1.8	3.4	-1.0	-0.7	1.6	-1.1	-1.8	-1.6	1.1
High blood pressure	1.4	4.0	10.6	1.7	-0.1	1.8	1.1	1.6	2.7	-3.2
Stomach or abdominal pain in last month	1.4	1.8	3.2	-1.7	-0.5	-1.8	1.1	-1.1	-0.9	1.7
Mouth/teeth dental problems	1.4	2.1	7.2	-1.3	-1.0	2.7	-1.7	-0.1	0.6	-1.4
Medication: Lansoprazole	1.4	1.6	3.2	-1.8	-0.9	-0.2	-0.0	-1.8	-1.3	1.6
Headache pain in last month	1.4	2.5	4.0	-2.0	-1.7	-0.5	-0.7	-1.9	-1.5	2.0
Whole body fat mass	1.4	5.7	12.9	2.9	2.9	-3.6	2.1	1.5	0.6	1.6
Rheumatoid Arthritis	1.3	1.7	3.8	2.0	1.1	-1.4	1.0	1.6	1.1	-0.5
Blood Eosinophil Count	1.3	9.9	29.8	0.4	1.9	1.0	3.0	3.1	3.9	-5.5
Lung FEV1/FVC ratio	1.3	6.7	27.1	1.5	-1.0	-5.2	-0.5	-0.6	-1.8	3.6
Medication: Metformin	1.3	1.9	5.9	1.0	1.8	-2.4	1.1	1.3	0.4	0.1
Average weekly fortified wine intake	1.3	1.5	5.5	-1.6	-1.0	2.3	-0.5	-0.9	-0.3	-0.3
Medication: Ramipril	1.3	1.7	4.0	-1.5	-2.0	1.7	-0.8	-0.8	0.0	-1.3
Illnesses of siblings: Diabetes	1.3	1.6	4.5	1.1	1.5	-0.5	2.1	1.3	1.2	-0.3
Long-standing illness, disability or infirmity	1.3	2.0	3.0	1.7	1.2	-0.8	1.1	1.7	1.7	-1.4
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.1	-1.3	-1.4	0.6	-0.7	-1.4	-1.4	1.4
Crohns Disease (2017)	1.2	2.6	3.5	1.5	1.3	-1.6	1.7	1.7	1.9	-1.7
Major Depression (MDD)	1.2	1.5	3.0	0.1	-0.7	1.6	1.2	0.6	1.7	-1.6
Lung FVC	1.2	6.0	8.2	-2.5	-2.3	-1.8	-2.9	-2.7	-2.8	2.0
Sensitivity / hurt feelings	1.2	2.0	5.4	-2.3	-1.4	2.1	0.3	-1.4	-0.5	0.4
Fed-up feelings	1.2	2.2	3.8	-1.7	-1.2	-0.9	0.7	-1.7	-1.6	2.0
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	2.9	-1.7	-1.6	1.1	-1.0	-1.5	-0.6	0.1
Happiness	1.2	1.4	2.8	-1.7	-0.9	0.8	-1.0	-1.5	-0.7	1.4
Medication for pain relief, constipation, heartburn	1.2	2.1	5.9	2.0	2.4	-0.7	1.4	1.4	0.4	0.6
Heart disease (mother)	1.2	1.4	4.2	-1.4	-2.0	1.6	-0.4	-0.9	-0.3	-0.7
Leg pain on walking	1.2	1.5	3.0	-0.6	-1.1	-0.8	-0.8	-1.7	-1.4	1.7
Mood swings	1.2	2.1	3.7	-1.7	-1.6	-0.8	-0.1	-1.9	-1.5	1.7
Back pain experienced in last month	1.2	1.7	3.9	1.5	1.1	-2.0	1.5	1.1	1.2	0.2
Arm fat mass (left)	1.2	4.8	16.1	2.1	2.2	-4.0	1.6	0.7	-0.3	2.4
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.7	1.3	0.4	-1.5	1.0	1.7	1.3	-0.5
Irritability	1.2	2.0	7.1	1.4	1.1	-2.7	1.6	0.8	0.4	0.7
Commuting to job workplace: Cycle	1.2	1.5	4.1	1.7	-0.2	2.0	-1.2	0.5	0.7	-1.1
Myopia	1.2	1.8	8.9	-0.5	1.0	3.0	-0.0	-0.5	-0.8	1.3
Vascular/heart problems diagnosed by doctor	1.2	3.4	8.5	-1.4	0.2	-1.7	-1.0	-1.5	-2.6	2.9
Lupus	1.1	1.6	6.4	1.6	2.5	-0.4	1.0	0.9	0.6	0.3
Relative age voice broke	1.1	1.7	2.7	1.5	0.6	-0.2	1.2	1.6	1.6	-1.5
Arm fat mass (right)	1.1	4.6	13.3	2.0	2.3	-3.7	1.5	0.7	-0.3	2.6
Exposure to tobacco smoke at home	1.1	1.2	6.5	1.2	-0.5	-2.6	-0.3	0.4	-0.1	-0.4
Overall health rating	1.1	2.3	7.1	-0.3	0.2	-2.7	0.4	-1.0	-1.4	2.4
Hypertension (Self-reported)	1.1	3.2	7.8	1.6	-0.4	2.1	0.7	1.3	2.3	-2.8
Illnesses of father: None of the above (group 1)	1.1	1.4	2.9	1.7	1.5	1.5	-0.5	1.3	0.5	0.1
Medication: Paracetamol	1.1	1.6	6.1	-1.9	-2.5	-0.5	0.1	-1.2	-0.3	-0.5
Medication: Lisinopril	1.1	1.4	3.0	0.4	-0.5	1.7	0.7	1.1	1.5	-1.5
Diastolic blood pressure, automated reading	1.1	3.3	7.2	1.6	1.0	1.2	1.5	1.9	2.7	-2.2
Ever depressed for a whole week	1.1	1.4	4.2	0.6	0.4	0.6	2.0	1.0	1.7	-1.0
Type 2 Diabetes (T2D) (2012)	1.0	1.2	3.1	0.1	-0.7	1.5	0.2	0.8	1.4	-1.8
Heel T-Score	1.0	7.6	16.4	0.6	1.0	3.6	1.4	3.2	3.2	-4.0
Hair/balding pattern: Pattern 3	1.0	1.4	5.1	1.0	0.6	-0.2	0.2	0.9	1.6	-2.3
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	2.7	1.3	0.7	1.6	0.2	1.2	1.4	-1.6
Age at first live birth	1.0	1.7	7.8	0.3	1.4	2.8	-1.1	0.7	0.4	-0.3
Eye problems/disorders: None of the above	1.0	1.2	2.8	-0.7	-0.7	-0.2	-1.3	-0.9	-1.4	1.7
Medication: Ibuprofen	1.0	1.2	2.2	-1.4	-1.5	-0.5	-0.8	-1.0	-0.9	1.1
Alcohol intake frequency.	1.0	2.4	4.3	2.1	1.2	-1.8	1.7	1.5	1.4	0.9
Family relationship satisfaction	1.0	1.2	4.2	2.1	0.8	1.7	-0.5	0.4	0.4	0.4
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.5	-0.9	0.4	-1.9	1.2	-0.9	-0.9	1.8
Ever taken oral contraceptive pill	1.0	1.1	4.1	0.5	1.0	-2.0	1.3	0.8	0.2	0.0
Commuting to job workplace: Public transport	1.0	1.2	4.8	0.5	-0.2	2.2	0.1	1.0	1.1	-1.1
Depression (Nagel 2018)	0.9	1.4	5.2	-0.7	-0.7	2.3	0.1	-1.4	-0.7	1.1
Age at First Birth	0.9	1.3	4.2	0.9	1.8	2.0	0.3	0.7	0.5	0.5
Multivitamins +/- minerals	0.9	1.2	3.6	0.6	1.4	-1.9	1.0	1.0	0.6	-0.4
Supplements: Glucosamine	0.9	1.1	2.1	1.1	1.0	-0.9	1.4	1.2	1.1	-0.3
Loud music exposure frequency	0.9	0.9	4.1	0.3	0.5	-2.0	0.9	0.8	0.6	-0.6
Angina (self-reported)	0.9	1.2	3.5	0.5	0.3	-0.5	0.6	1.1	1.9	-1.6
Age at last live birth	0.9	1.3	2.4	0.3	1.6	1.3	0.5	1.6	1.1	-0.9
Osteoarthritis (self-reported)	0.9	1.1	2.4	-1.5	-0.8	-1.2	-0.4	-1.6	-0.8	0.6
Miserableness	0.9	1.5	3.7	0.9	1.2	-1.9	1.9	0.8	0.5	0.5
Heart disease (siblings)	0.9	1.0	4.2	0.6	0.2	-0.5	0.2	1.0	1.2	-2.0
Depressed Affect (Nagel 2018)	0.8	1.8	3.6	-1.5	-1.1	0.1	0.8	-1.8	-1.2	1.9
Alzheimer’s Disease (in father)	0.8	0.9	1.9	-1.2	-0.3	-0.1	0.1	-1.2	-1.1	1.4
Ovarian Cancer	0.8	1.1	3.7	-0.6	1.2	-1.1	1.9	0.1	-0.2	0.8
Angina	0.8	1.0	2.8	0.7	0.6	-0.3	0.7	1.1	1.7	-1.2
Pain all over the body in last month	0.8	0.9	1.8	-1.3	-1.1	-0.8	-0.7	-1.1	-0.8	0.5
Arm fat percentage (right)	0.8	3.1	10.1	0.3	0.8	-2.5	0.0	-1.2	-1.8	3.2
Number of live births	0.8	1.1	3.5	-1.9	-0.7	1.5	0.4	-0.6	0.2	-1.1
Breastfed as a baby	0.8	1.0	4.3	-0.9	-0.8	2.1	-0.7	-0.4	0.2	-0.8
Wheeze or whistling in the chest in last year	0.8	1.5	5.2	-0.9	0.6	-2.3	1.7	-0.4	-0.7	0.8
Medication: Allopurinol	0.8	1.1	2.5	1.5	0.6	1.6	-0.1	0.8	0.8	-1.0
Illnesses of father: Heart disease	0.8	1.1	3.3	-0.2	-0.2	0.1	0.8	0.9	1.7	-1.8
Arm fat percentage (left)	0.8	3.2	10.1	0.2	0.2	-2.4	-0.3	-1.5	-2.1	3.2
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.5	0.7	0.3	-1.6	0.9	0.9	1.1	-0.7
Osteoporosis (self-reported)	0.8	1.0	2.3	-0.7	-1.5	0.7	-0.9	-1.4	-0.9	0.3
Number of self-reported non-cancer illnesses	0.8	1.3	3.1	-1.2	-1.8	0.9	-0.5	-1.6	-0.9	-0.4
Breast Cancer	0.7	1.6	4.4	-0.9	-0.5	0.6	-1.3	-1.3	-1.3	2.1
LDL Cholesterol	0.7	1.1	3.2	-1.8	-0.8	-0.5	-0.1	-1.3	-0.9	1.0
Chronotype (morning person)	0.7	1.7	4.6	1.8	1.0	1.1	0.2	0.7	-0.9	2.2
Qualifications: CSEs or equivalent	0.7	0.9	3.1	-0.5	0.2	-1.8	1.1	-0.5	-0.7	1.1
Medication: Levothyroxine sodium	0.7	1.1	2.2	-0.6	-1.3	-0.4	-0.4	-1.0	-1.5	1.5
Illnesses of siblings	0.7	1.0	3.3	-1.0	-0.7	0.8	-1.8	-0.6	-0.8	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	3.4	-1.4	-0.4	-0.2	1.8	-0.4	1.0	-0.8
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.5	0.1	-0.7	-1.2	1.1	0.3	1.2	-1.2
High blood pressure (siblings)	0.7	1.0	2.7	0.6	0.1	-0.2	1.6	0.7	1.3	-1.2
Comparative body size at age 10	0.7	2.0	7.3	1.6	1.4	-2.7	0.1	0.5	-0.0	1.4
Emphysema/chronic bronchitis	0.7	0.8	2.5	-0.4	0.1	-1.2	1.6	-0.4	-0.4	1.0
Neck or shoulder pain in last month	0.7	1.0	3.7	-0.8	-0.6	-1.9	-0.5	-1.1	-0.6	0.2
Medication: Blood pressure	0.7	1.2	3.8	0.8	-0.3	1.1	0.1	0.8	1.4	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.9	0.8	0.5	-1.7	0.5	-0.2	-0.8	0.9
Pulse rate, automated reading	0.7	2.1	7.1	-2.7	-1.5	1.3	-0.6	-1.8	-0.4	-0.0
Guilty feelings	0.7	1.0	2.9	-0.6	-0.9	1.7	-0.5	-1.0	-1.2	0.7
Wears glasses or contact lenses	0.7	0.8	2.7	-1.0	0.5	1.6	-0.2	-0.3	0.8	-0.7
Medication: Blood pressure	0.7	1.3	2.8	0.8	0.5	0.4	1.7	0.8	1.7	-1.4
Unable to work because of sickness or disability	0.7	0.9	2.6	1.5	0.4	-1.6	-0.2	0.9	0.6	-0.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	4.0	-0.6	-0.4	0.6	-0.3	-0.1	0.7	-2.0
Medication for hormone replacement therapy	0.6	0.7	2.7	0.5	-0.8	-1.1	0.0	0.5	0.2	-1.6
Diabetes (father)	0.6	0.7	3.4	0.3	0.2	-1.9	0.7	0.3	0.2	0.8
Financial difficulties in last 2 years	0.6	0.8	2.9	1.7	0.3	-1.5	0.1	0.2	0.5	0.4
Heart attack	0.6	0.7	2.0	-0.6	-1.4	0.1	-0.2	0.4	0.9	-1.3
Noisy workplace	0.6	0.7	4.3	-0.1	0.1	-2.1	-0.2	-0.6	-0.5	-0.1
Prospective memory result	0.6	0.7	1.7	-0.5	1.0	0.1	1.2	-0.4	-0.4	1.3
Medication: Amlodipine	0.6	0.9	1.8	-0.3	-1.0	1.0	-1.3	-1.1	-0.8	0.3
Leg fat percentage (right)	0.6	2.1	6.1	0.9	0.7	-2.4	0.5	-0.5	-1.0	2.5
Chest pain or discomfort	0.6	0.9	4.8	-0.3	-0.6	-2.2	0.3	-0.7	-0.5	0.7
Loneliness, isolation	0.6	0.9	1.7	-0.1	-0.4	1.1	-1.0	-1.3	-1.1	0.8
Medication for cholesterol	0.6	1.0	2.7	0.3	-0.2	-0.7	-1.6	-0.1	-1.0	1.6
Medication: Gliclazide	0.6	0.6	2.2	0.5	1.5	0.3	0.7	0.4	-0.1	1.1
Leg fat percentage (left)	0.6	2.3	7.7	1.1	0.9	-2.2	0.6	-0.4	-1.1	2.8
Pain experienced in last month	0.6	1.0	2.5	1.6	1.0	1.0	0.3	1.4	0.3	-0.3
HbA1C	0.5	0.6	1.6	-1.2	-1.1	0.8	-0.4	-0.5	-0.6	-0.0
Hypothyroidism (self reported)	0.5	1.2	3.0	0.7	0.7	-1.6	1.7	1.3	0.6	-0.0
Average weekly spirits intake	0.5	0.6	4.2	-0.1	-0.2	-2.1	0.3	-0.0	-0.1	-0.2
Medication: Co-codamol	0.5	0.6	3.0	-0.3	-1.7	0.2	-0.7	-0.6	-0.6	0.3
Health satisfaction	0.5	0.6	2.2	0.1	0.9	-0.2	1.0	-0.3	0.1	1.5
Eye problems/disorders: Cataract	0.5	0.6	2.3	0.6	0.9	0.3	1.5	0.6	0.3	-0.0
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.9	-0.6	-1.4	-0.1	-0.2	0.3	0.8	-1.2
Primary Biliary Cirrhosis	0.4	0.6	2.0	-0.8	-0.3	-1.4	0.4	0.0	0.6	-0.9
Tanning	0.4	5.0	21.4	4.6	2.6	-0.5	0.9	2.2	1.1	-0.4
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	-1.0	-0.2	-0.7	0.6	-0.3	-0.6	1.1
Tense / ‘highly strung’	0.4	0.7	2.4	-0.4	-1.6	0.4	-1.0	-0.7	-0.7	0.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.6	1.3	1.0	-0.4	0.6	0.3	-0.3	-0.0
Glaucoma (self-reported)	0.4	0.5	1.1	-0.1	-0.9	1.1	-1.0	-0.5	-0.2	-0.1
Body fat percentage	0.4	1.6	4.7	1.1	1.0	-1.7	0.6	-0.5	-0.9	2.2
Number of full brothers	0.4	0.6	1.1	1.0	-0.4	-1.0	-0.2	-0.6	-0.8	0.7
Number of children fathered	0.4	0.5	0.9	1.0	0.3	0.1	-0.1	0.9	0.9	-0.8
Medication: Seretide 50 evohaler	0.4	0.5	1.4	0.8	1.2	-0.6	0.8	0.5	0.2	0.1
Had major operations	0.4	0.5	1.7	1.3	0.6	-1.0	0.4	0.4	0.1	-0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.6	-0.6	0.5	0.6	-0.8	-0.8	-1.2	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.5	0.5	-0.2	0.0	0.3	0.8	1.2	-1.0
Breast cancer (self-reported)	0.4	0.5	1.9	1.4	0.6	0.9	-0.3	0.4	0.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.3	0.8	-0.7	0.5	-1.5	0.5	-0.7	1.4
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	-0.1	-0.7	1.0	-0.5	0.2	0.8	-0.9
Age started oral contraceptive pill	0.4	0.5	2.1	-0.5	1.4	-0.1	0.8	0.4	0.5	-0.2
Supplements: Calcium	0.4	0.4	0.8	0.5	0.9	-0.9	0.6	-0.2	-0.4	0.8
Alcohol drinker status: Previous	0.4	0.5	3.1	0.4	0.1	1.8	0.2	-0.0	0.2	-0.4
Triglycerides	0.3	0.4	2.0	-0.4	0.4	-1.4	0.5	-0.1	0.6	-0.5
Blood Red Count	0.3	2.6	11.4	0.1	-0.6	1.9	0.5	0.1	1.6	-3.4
Number of treatments/medications taken	0.3	0.5	1.7	-0.3	-1.1	-0.1	0.4	-0.2	0.7	-1.3
Trunk fat percentage	0.3	1.2	2.7	1.1	1.3	-1.3	0.8	-0.2	-0.6	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.5	0.9	0.4	0.1	0.5	-0.3	-0.5	1.2
Taking other prescription medications	0.3	0.4	0.9	-0.5	-0.7	1.0	0.0	-0.9	-0.4	-0.0
Had other major operations	0.3	0.4	1.7	-0.7	-0.3	1.3	-0.3	-0.3	0.0	-0.1
Falls in the last year	0.3	0.4	0.9	1.0	0.5	-0.5	0.5	0.4	0.9	-0.1
Depression (self-reported)	0.3	0.4	1.2	-1.1	0.4	-0.4	0.6	-0.7	-0.3	0.7
Illnesses of mother	0.3	0.4	0.8	-0.2	0.9	-0.1	-0.6	-0.7	-0.6	0.7
Medication: Omeprazole	0.3	0.4	1.1	-0.4	-0.6	-0.2	0.6	0.3	0.8	-1.1
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	0.8	0.4	-0.3	0.7	1.0	0.6	-0.1
High cholesterol (Self-reported)	0.3	0.6	1.7	0.4	1.3	-0.0	0.9	0.5	0.8	-0.8
Cholesterol lowering medication	0.3	0.4	1.5	-0.4	-0.4	0.9	-0.1	-0.3	0.3	-1.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	-0.3	0.7	0.8	0.8	0.1	-0.2	0.6
HDL Cholesterol	0.2	0.4	0.9	-1.0	-0.9	0.7	-0.3	-0.2	0.0	-0.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.4	-0.0	0.3	1.2	0.7	0.1	0.4	-0.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	0.6	-0.1	0.4	-0.3	-0.6	-0.5	0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	1.0	1.0	0.3	0.0	0.4	0.3	0.5	-0.0
Time employed in main current job	0.2	0.3	1.1	-1.1	0.4	0.4	0.2	-0.2	-0.3	0.6
Hair/balding pattern: Pattern 4	0.2	0.5	1.4	0.2	0.8	0.4	1.2	0.9	0.9	0.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	-0.4	-0.4	-0.3	-0.3	-0.5	-1.0	0.8
Gout (self-reported)	0.2	0.3	1.3	0.2	0.8	1.1	0.2	0.0	0.3	-0.5
Number of full sisters	0.2	0.2	1.0	0.4	0.4	-1.0	0.4	-0.0	-0.5	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.0	0.5	-0.0	-0.2	1.0	0.1	0.4	-0.2
Hearing aid user	0.2	0.2	1.2	0.1	-1.1	-0.5	0.2	-0.1	0.2	0.2
Illnesses of father: High blood pressure	0.2	0.3	1.2	-0.2	-1.1	-0.8	0.1	-0.2	-0.2	0.2
Alcohol drinker status: Never	0.2	0.2	0.4	-0.2	-0.4	0.5	-0.5	-0.2	-0.4	0.7
Average weekly beer plus cider intake	0.2	0.3	1.2	0.1	0.2	-0.6	0.5	0.1	0.1	-1.1
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	0.1	0.5	0.3	0.4	0.3	0.2	-0.3
Medication: Simvastatin	0.1	0.1	0.4	-0.0	0.4	-0.6	0.6	-0.1	0.3	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	0.2	-0.2	0.2	-0.2	0.2	0.2	-0.6
Medication: Cholesterol lowering	0.1	0.1	0.3	-0.2	0.5	-0.6	0.1	-0.3	-0.2	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.9	0.1	-0.9	0.4	0.2	0.1	-0.0	-0.1
Medication: Atorvastatin	0.1	0.2	0.4	0.5	0.3	-0.2	0.1	0.4	0.4	-0.7
Number of operations (self-reported)	0.1	0.2	0.5	-0.4	0.3	0.7	0.4	-0.3	-0.2	0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.7	-0.8	-0.2	-0.1	0.0	-0.2	0.3	-0.4
Hair Pigment	0.0	0.7	2.8	-1.7	-0.7	0.5	1.0	-0.5	0.2	-0.3

Hub : Genes

ACTR1A

Models

Trait associations